Dr Susannah Tye

Senior Research Fellow

Queensland Brain Institute
s.tye@uq.edu.au
+61 7 344 32493

Overview

Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.

Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.

Research Interests

  • Deep Brain Stimulation
  • Neuromodulation
  • Depression
  • Bipolar Disorder
  • Stress Disorders
  • Parkinson's Disease
  • Biomarkers
  • Refractory Psychiatric Illness

Research Impacts

The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.

Qualifications

  • Doctor of Philosophy, Macquarie University

Publications

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book Chapter

  • Kim, Yesul, Wininger, Katheryn M. and Tye, Susannah J. (2016). Deep brain stimulation for treatment-resistant depression. Deep brain stimulation: indications and applications. (pp. 197-214) edited by Kendall H. Lee, Penelope S. Duffy and Allan J. Bieber. New York, NY, United States: Jenny Stanford Publishing. doi: 10.1201/9781315364759

Journal Article

Conference Publication

  • Varella, R. B., Boschen, S. L., Blaha, C. D., Chye, N., Ghandi, K., Valvassori, S. S. and Tye, S. J. (2019). Antidepressant and antimanic effects of deep brain stimulation of the ventral tegmental area. 21st Annual ISBD Conference on Global Advances in Bipolar Disorder and Depression, Sydney Australia, Mar 20-23, 2019. HOBOKEN: WILEY. doi: 10.1111/bdi.12745

  • Blair, Joshua, Morath, Brooke, Butters, Kim, Frye, Mark, McGee, Sean and Tye, Susannah (2019). Molecular, cellular, and bioenergetic actions of ketamine and lithium combinatorial treatment in antidepressant resistant rats. 58th Annual Meeting of the American College of Neuropsychopharmacology , Orlando, Florida, 8-11 December 2019 . London, United Kingdom: Nature Publishing Group.

  • Pfeiffer, John, Bustamante, Angela, Price, Joshua, Tye, Susannah and Uddin, Monica (2017). 501. Epigenetic modifications of stress-relevant genes as peripheral biomarkers of treatment-resistant depression. 72nd Annual Scientific Convention and Meeting, San Diego, CA, United States, 15 May 2017. Elsevier BV. doi: 10.1016/j.biopsych.2017.02.1109

  • Adams, Scott, Kouzani, Abbas Z., Bennet, Kevin and Tye, Susannah J. (2017). Towards in-vivo ATP sensing. 2016 IEEE Region 10 Conference (TENCON), Singapore, 22-25 November 2016. Piscataway, NJ United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/TENCON.2016.7848474

  • Parastarfeizabadi, Mahboubeh, Kouzani, Abbas Z., Gibson, Ian and Tye, Susannah J. (2016). A miniature closed-loop deep brain stimulation device. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, Florida, 16-20 August 2016 . Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/embc.2016.7591064

  • Edward, Epsy S., Kouzani, Abbas Z., Berk, Julian and Tye, Susannah J. (2016). A miniature neural recording device. IEEE International Conference on Industrial Technology, ICIT 2016, Taipei, Taiwan, 14-17 March 2016. Piscataway, NJ United States: IEEE. doi: 10.1109/icit.2016.7474892

  • Kale, Rajas P., Kouzani, Abbas Z., Berk, Julian, Walder, Ken, Berk, Michael and Tye, Susannah J. (2016). Electrical resistance increases at the tissue-electrode interface as an early response to nucleus accumbens deep brain stimulation. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, FL, United States, 16-20 August 2016. Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/EMBC.2016.7591071

  • Edward, Epsy S., Kouzani, Abbas Z., Kale, Rajas P. and Tye, Susannah J. (2016). Portable closed-loop optogenetic stimulation device. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, Florida, 16-20 August 2016 . Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/embc.2016.7591911

  • Veerabhadrappa, Rakesh, Bhatti, Asim, Lim, Chee Peng, Nguyen, Thanh Thi, Tye, S. J., Monaghan, Paul and Nahavandi, Saeid (2015). Statistical modelling of artificial neural network for sorting temporally synchronous spikes. 22nd International Conference on Neural Information Processing, ICONIP 2015, Istanbul, Turkey, 9-12 November 2015. Heidelberg, 69121 Germany: Springer Verlag. doi: 10.1007/978-3-319-26555-1_30

  • Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah J., Abulseoud, Osama A. and Berk, Michael (2013). Design and analysis of an antenna for wireless energy harvesting in a head-mountable DBS device. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, Osaka, Japan, 3-7 July 2013. Piscataway, NJ, United States: IEEE. doi: 10.1109/EMBC.2013.6610191

  • Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah, Mortazavi, Daryoush and Kaynak, Akif (2012). Compact stacked planar inverted-F antenna for passive deep brain stimulation implants. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Diego, CA USA, 28 August-1 September 2012. doi: 10.1109/EMBC.2012.6346065

  • Hosain, Md. Kamal, Kouzani, Abbas Z., Tye, Susannah, Walder, Ken and Kong, Lingxue (2012). Design of a miniature UHF PIFA for DBS implants. 6th International Conference on Complex Medical Engineering, CME 2012, Kobe, Japan, 1-4 July 2012. Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/ICCME.2012.6275746

  • Hosain, Md Kamal, Kouzani, Abbas and Tye, Susannah (2012). Multi-layer implantable antenna for closed loop deep brain stimulation system. 2012 International Symposium on Communications and Information Technologies, ISCIT 2012, Gold Coast, QLD, Australia, 2-5 October 2012. Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/ISCIT.2012.6380979

  • Kouzani, Abbas Z., Tye, Susannah, Walder, Ken and Kong, Lingxue (2011). A head mountable deep brain stimulation device for laboratory animals. 2011 International Conference on Computer, Communication, Control and Automation, 3CA 2011, , , November 19, 2011-November 20, 2011. doi: 10.1007/978-3-642-25541-0_36

  • Kimble, Christopher J., Johnson, David M., Winter, Bruce A., Whitlock, Sidney V., Kressin, Kenneth R., Horne, April E., Robinson, Justin C., Bledsoe, Jonathan M., Tye, Susannah J., Chang, Su-Youne, Agnesi, Filippo, Griessenauer, Christoph J., Covey, Daniel, Shon, Young-Min, Bennet, Kevin E., Garris, Paul A. and Lee, Kendall H. (2009). Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring. 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 2- 6 September, 2009. Piscataway, NJ, United States: IEEE Computer Society. doi: 10.1109/IEMBS.2009.5332773

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors: