Dr Daniel Liang-Dar Hwang is a genetic epidemiologist and statistical geneticist by training. His research interests include sensory nutrition, causal modelling, and personalized nutrition. Dr Hwang applies statistical models to big data to understand genetic and environmental factors contributing to individual differences in taste and olfactory perception, their relationship with dietary behaviour and chronic conditions (See his research on taste perception in The Conversation). He develops methods for increasing statistical power for gene discovery, estimating intergenerational causal relationships, and personalized intervention. He also works with clinicians to investigate impaired chemosensory perception in patients with cancers and COVID-19.
Daniel has a B.Sc from the National Taiwan University, majoring in Biochemical Science and Technology, and a M.Biotech from the University of Pennsylvania. Following graduation, he worked as a research technician in Danielle Reed' lab at the Monell Chemical Senses Center where he first developed a keen interest in genetics and chemosensory perception. Later he was awarded scholarships to complete a M.Sc in Nutrition at the University of Washington, under the supervision of Glen Duncan, and a Ph.D in Genetic Epidemiology at the QIMR Berghofer Medical Research Institute, under the supervision of Nicholas Martin and Margaret Wright. He then joined David Evans's group at the University of Queensland Diamantina Institue (now the Frazer Institute) as a postdoc. Dr Hwang is currently a research fellow at the Institute for Molecular Bioscience.
Dr Hwang has published more than 35 peer-review publications. His work has been referred in international health policy guidelines and a WHO report for the intervention of childhood obesity and in an international patent for personalized wine selection. He is on the editorial boards of the Twin Research and Human Genetics (2020-) and the Frontiers in Genetics (2021-). Dr Hwang is a Leadership Team member of the Global Consortium for Chemosensory Research (2022-), a global initiative to understand the relationship between smell loss and COVID-19 and foster the advancement of chemosensory science at large. He currently drives an international collaborative project to investigate the impact of COVID-19 vaccinations on long-COVID symptoms. Dr Hwang is a member of the National Committee for Nutrition of the Australian Academy of Science (2022-) where he contributes to the implementation of the decadal plan for the science of nutrition in Australia.
Conference Publication: Consumption of diets rich in animal protein, saturated fat, or sodium, and low in fibre are associated with increased risk of acute appendicitis
Ryoo, M., Hwang, D., Wright, O., Brown, J. and Roura, E. (2023). Consumption of diets rich in animal protein, saturated fat, or sodium, and low in fibre are associated with increased risk of acute appendicitis. 46th Annual Scientific Meeting of the Nutrition Society of Australia, Perth, WA Australia, 29 November – 2 December 2022. Cambridge, United Kingdom: Cambridge University Press. doi: 10.1017/s0029665123001258
Conference Publication: Increased risk of acute appendicitis linked to biological sex, ethnic background, obesity, and smoking status
Ryoo, M., Hwang, D., Wright, O., Brown, J. and Roura, E. (2023). Increased risk of acute appendicitis linked to biological sex, ethnic background, obesity, and smoking status. 46th Annual Scientific Meeting of the Nutrition Society of Australia, Perth, WA Australia, 29 November – 2 December 2022. Cambridge, United Kingdom: Cambridge University Press. doi: 10.1017/s0029665123001714
Journal Article: Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk
D’Urso, Shannon, Arumugam, Pooja, Weider, Therese, Hwang, Liang-Dar, Bond, Tom A., Kemp, John P., Warrington, Nicole M., Evans, David M., O’Mara, Tracy A. and Moen, Gunn-Helen (2022). Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk. BMC Medicine, 20 (1) 419, 1-17. doi: 10.1186/s12916-022-02585-w
Causal relationship between taste and smell perception and eating behaviour
(2024–2027) ARC Discovery Early Career Researcher Award
(2023) Doctor Philosophy
Dietary patterns and molecular mechanisms associated with the pathogenicity of appendicitis in humans
Doctor Philosophy
Multi-omic Approaches to Understanding Septic Shock
Doctor Philosophy
Develop novel approaches for personalised nutrition using large-scale genetically informative data
Polygenic risk scores have provided informative predictions for highly heritable traits and has been intergrated into risk prediction models along with traditional clinicial measurements to improvde risk prediction of cardiometabolic disease and other inherited health conditions. This project aims to develop novel polygenic scores specifically for priotising interventions or "personalised intervention" rather than risk prediction.
Impact of COVID-19 vaccinations on long-COVID symptoms
This project aims to investigate post-vaccination changes in the perception of smell and taste and other symptoms of long-COVID using data collected from the Global Consortium for Chemosensory Research (https://gcchemosensr.org/). The results will help assess the potential impact of COVID-19 vaccines and provide new clues to help us understand recovery from long-COVID.
Supertaster gene and picky eating
This study will involve collecting genetic, dietary, and sensory data from young children and their parents to perform a comprehensive analysis to understand factors contributing to picking eating behaviour in young children.
Integrating family-based and Mendelian randomization designs
Hwang, Liang-Dar, Davies, Neil M., Warrington, Nicole M. and Evans, David M. (2022). Integrating family-based and Mendelian randomization designs. Combining human genetics and causal inference to understand human disease and development. (pp. 137-150) edited by George Davey Smith, Rebecca Richmond and Jean-Baptiste Pingault. Cold Spring Harbor, NY, United States: Cold Spring Harbor Laboratory Press.
D’Urso, Shannon, Arumugam, Pooja, Weider, Therese, Hwang, Liang-Dar, Bond, Tom A., Kemp, John P., Warrington, Nicole M., Evans, David M., O’Mara, Tracy A. and Moen, Gunn-Helen (2022). Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk. BMC Medicine, 20 (1) 419, 1-17. doi: 10.1186/s12916-022-02585-w
Hwang, Liang-Dar, Moen, Gunn-Helen and Evans, David M. (2022). Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes. eLife, 11 e73671, 1-27. doi: 10.7554/elife.73671
Brito Nunes, Caroline, Huang, Peiyuan, Wang, Geng, Lundberg, Mischa, D’Urso, Shannon, Wootton, Robyn E., Borges, Maria Carolina, Lawlor, Deborah A., Warrington, Nicole M., Evans, David M., Hwang, Liang-Dar and Moen, Gunn-Helen (2022). Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth. International Journal of Epidemiology, 52 (1), 1-13. doi: 10.1093/ije/dyac121
Ohla, K, Veldhuizen, M G, Green, T, Hannum, M E, Bakke, A J, Moein, S T, Tognetti, A, Postma, E M, Pellegrino, R, Hwang, D L D, Albayay, J, Koyama, S, Nolden, A A, Thomas-Danguin, T, Mucignat-Caretta, C, Menger, N S, Croijmans, I, Öztürk, L, Yanık, H, Pierron, D, Pereda-Loth, V, Nunez-Parra, A, Martinez Pineda, A M, Gillespie, D, Farruggia, M C, Cecchetto, C, Fornazieri, M A, Philpott, C, Voznessenskaya, V ... Niv, M Y (2022). A follow-up on quantitative and qualitative olfactory dysfunction and other symptoms in patients recovering from COVID-19 smell loss. Rhinology, 60 (3), 207-217. doi: 10.4193/Rhin21.415
Exploring polygenic contributors to subgroups of comorbid conditions in autism spectrum disorder
Klein, Louis, D’Urso, Shannon, Eapen, Valsamma, Hwang, Liang-Dar and Lin, Ping-I (2022). Exploring polygenic contributors to subgroups of comorbid conditions in autism spectrum disorder. Scientific Reports, 12 (1) 3416. doi: 10.1038/s41598-022-07399-7
Wang, Geng, Bhatta, Laxmi, Moen, Gunn-Helen, Hwang, Liang-Dar, Kemp, John P., Bond, Tom A., Åsvold, Bjørn Olav, Brumpton, Ben, Evans, David M. and Warrington, Nicole M. (2022). Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health. Hypertension, 79 (1), 170-177. doi: 10.1161/hypertensionaha.121.17701
Warrington, Nicole M., Hwang, Liang-Dar, Nivard, Michel G. and Evans, David M. (2021). Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data. Nature Communications, 12 (1) 5420, 1-12. doi: 10.1038/s41467-021-25723-z
Hwang, Liang-Dar, Mitchell, Brittany L., Medland, Sarah E., Martin, Nicholas G., Neale, Michael C. and Evans, David M. (2021). Correction to: The augmented Classical Twin Design: incorporating genome‐wide identity by descent sharing into twin studies in order to model violations of the equal environments assumption. Behavior Genetics, 51 (4), 441-442. doi: 10.1007/s10519-021-10065-9
Ong, Jue-Sheng, Derks, Eske M., Eriksson, Mikael, An, Jiyuan, Hwang, Liang-Dar, Easton, Douglas F., Pharoah, Paul P., Berchuck, Andrew, Kelemen, Linda E., Matsuo, Keitaro, Chenevix-Trench, Georgia, Hall, Per, Bojesen, Stig E., Webb, Penelope M. and MacGregor, Stuart (2021). Evaluating the role of alcohol consumption in breast and ovarian cancer susceptibility using population-based cohort studies and two-sample Mendelian randomization analyses. International Journal of Cancer, 148 (6) ijc.33308, 1338-1350. doi: 10.1002/ijc.33308
Hwang, Liang-Dar, Mitchell, Brittany L., Medland, Sarah E., Martin, Nicholas G., Neale, Michael C. and Evans, David M. (2021). The augmented Classical Twin Design: incorporating genome‐wide identity by descent sharing into twin studies in order to model violations of the equal environments assumption. Behavior Genetics, 51 (3), 223-236. doi: 10.1007/s10519-021-10044-0
Tubbs, Justin D., Hwang, Liang-Dar, Luong, Justin, Evans, David M. and Sham, Pak C. (2021). Modeling parent-specific genetic nurture in families with missing parental genotypes: application to birthweight and BMI. Behavior Genetics, 51 (3), 289-300. doi: 10.1007/s10519-020-10040-w
Parma, Valentina, Ohla, Kathrin, Veldhuizen, Maria G., Niv, Masha Y., Kelly, Christine E., Bakke, Alyssa J., Cooper, Keiland W., Bouysset, Cédric, Pirastu, Nicola, Dibattista, Michele, Kaur, Rishemjit, Liuzza, Marco Tullio, Pepino, Marta Y., Schöpf, Veronika, Pereda-Loth, Veronica, Olsson, Shannon B., Gerkin, Richard C., Rohlfs Domínguez, Paloma, Albayay, Javier, Farruggia, Michael C., Bhutani, Surabhi, Fjaeldstad, Alexander W., Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Di Pizio, Antonella, Genovese, Federica ... GCCR Group (2021). Corrigendum to: More Than Smell—COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis. Chemical Senses, 46. doi: 10.1093/chemse/bjab050
Gerkin, Richard C, Ohla, Kathrin, Veldhuizen, Maria G, Joseph, Paule V, Kelly, Christine E, Bakke, Alyssa J, Steele, Kimberley E, Farruggia, Michael C, Pellegrino, Robert, Pepino, Marta Y, Bouysset, Cédric, Soler, Graciela M, Pereda-Loth, Veronica, Dibattista, Michele, Cooper, Keiland W, Croijmans, Ilja, Di Pizio, Antonella, Ozdener, Mehmet Hakan, Fjaeldstad, Alexander W, Lin, Cailu, Sandell, Mari A, Singh, Preet B, Brindha, V Evelyn, Olsson, Shannon B, Saraiva, Luis R, Ahuja, Gaurav, Alwashahi, Mohammed K, Bhutani, Surabhi, D'Errico, Anna ... Navarro, Marta (2021). Recent smell loss is the best predictor of COVID-19 among individuals with recent respiratory symptoms. Chemical Senses, 46. doi: 10.1093/chemse/bjaa081
D'Urso, Shannon, Wang, Geng, Hwang, Liang-Dar, Moen, Gunn-Helen, Warrington, Nicole M. and Evans, David M. (2020). A cautionary note on using Mendelian randomization to examine the Barker hypothesis and Developmental Origins of Health and Disease (DOHaD). Journal of Developmental Origins of Health and Disease, 12 (5), 1-6. doi: 10.1017/S2040174420001105
Hwang, Liang-Dar, Tubbs, Justin D., Luong, Justin, Lundberg, Mischa, Moen, Gunn-Helen, Wang, Geng, Warrington, Nicole M., Sham, Pak C., Cuellar-Partida, Gabriel and Evans, David M. (2020). Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs. PLoS Genetics, 16 (10) e1009154, e1009154. doi: 10.1371/journal.pgen.1009154
Haworth, Simon, Kho, Pik Fang, Holgerson, Pernilla Lif, Hwang, Liang-Dar, Timpson, Nicholas J., Rentería, Miguel E., Johansson, Ingegerd and Cuellar-Partida, Gabriel (2020). Assessment and visualization of phenome-wide causal relationships using genetic data: an application to dental caries and periodontitis. European Journal of Human Genetics, 29 (2), 300-308. doi: 10.1038/s41431-020-00734-4
Genome-wide association study identifies 48 common genetic variants associated with handedness
Cuellar-Partida, Gabriel, Tung, Joyce Y., Eriksson, Nicholas, Albrecht, Eva, Aliev, Fazil, Andreassen, Ole A., Barroso, Inês, Beckmann, Jacques S., Boks, Marco P., Boomsma, Dorret I., Boyd, Heather A., Breteler, Monique M. B., Campbell, Harry, Chasman, Daniel I., Cherkas, Lynn F., Davies, Gail, de Geus, Eco J. C., Deary, Ian J., Deloukas, Panos, Dick, Danielle M., Duffy, David L., Eriksson, Johan G., Esko, Tõnu, Feenstra, Bjarke, Geller, Frank, Gieger, Christian, Giegling, Ina, Gordon, Scott D., Han, Jiali ... Medland, Sarah E. (2020). Genome-wide association study identifies 48 common genetic variants associated with handedness. Nature Human Behaviour, 5 (1), 59-70. doi: 10.1038/s41562-020-00956-y
More than smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis
Parma, Valentina, Ohla, Kathrin, Veldhuizen, Maria G., Niv, Masha Y., Kelly, Christine E., Bakke, Alyssa J., Cooper, Keiland W., Bouysset, Cédric, Pirastu, Nicola, Dibattista, Michele, Kaur, Rishemjit, Liuzza, Marco Tullio, Pepino, Marta Y., Schöpf, Veronika, Pereda-Loth, Veronica, Olsson, Shannon B., Gerkin, Richard C., Rohlfs Domínguez, Paloma, Albayay, Javier, Farruggia, Michael C., Bhutani, Surabhi, Fjaeldstad, Alexander W., Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Di Pizio, Antonella, Genovese, Federica ... Hayes, John E. (2020). More than smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis. Chemical Senses, 45 (7), 609-622. doi: 10.1093/chemse/bjaa041
Mitchell, Brittany L., Cuéllar-Partida, Gabriel, Grasby, Katrina L., Campos, Adrian I., Strike, Lachlan T., Hwang, Liang-Dar, Okbay, Aysu, Thompson, Paul M., Medland, Sarah E., Martin, Nicholas G., Wright, Margaret J. and Rentería, Miguel E. (2020). Educational attainment polygenic scores are associated with cortical total surface area and regions important for language and memory. NeuroImage, 212 116691, 116691. doi: 10.1016/j.neuroimage.2020.116691
Hwang, Liang-Dar and Evans, David M. (2020). Proxy gene-by-environment Mendelian randomization for assessing causal effects of maternal exposures on offspring outcomes. International Journal of Epidemiology, 49 (4), 1218-1220. doi: 10.1093/ije/dyaa069
Ong, Jue-Sheng, Hwang, Liang-Dar, Zhong, Victor W., An, Jiyuan, Gharahkhani, Puya, Breslin, Paul A. S., Wright, Margaret J., Lawlor, Deborah A., Whitfield, John, MacGregor, Stuart, Martin, Nicholas G. and Corneli, Marilyn C. (2020). Author Correction: Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization. Scientific Reports, 10 (1) 4778, 4778. doi: 10.1038/s41598-020-60488-3
Integrating family-based and Mendelian randomization designs
Hwang, Liang-Dar, Davies, Neil M., Warrington, Nicole M. and Evans, David M. (2020). Integrating family-based and Mendelian randomization designs. Cold Spring Harbor Perspectives in Medicine, 11 (3) a039503, 1-15. doi: 10.1101/cshperspect.a039503
Hwang, Liang-Dar (2020). Do people with lower IQ have weaker taste perception? A hidden supplementary table in 'Is the Association between Sweet and Bitter Perception Due to Genetic Variation?'. Twin Research and Human Genetics, 23 (2), 1-2. doi: 10.1017/thg.2020.19
Nolden, Alissa A., Hwang, Liang-Dar, Boltong, Anna and Reed, Danielle R. (2019). Chemosensory changes from cancer treatment and their effects on patients’ food behavior: a scoping review. Nutrients, 11 (10) 2285, 2285. doi: 10.3390/nu11102285
Hwang, Liang-Dar, Lawlor, Deborah A., Freathy, Rachel M., Evans, David M. and Warrington, Nicole M. (2019). Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight. International Journal of Epidemiology, 48 (5), 1457-1467. doi: 10.1093/ije/dyz160
Hwang, Liang-Dar, Lin, Cailu, Gharahkhani, Puya, Cuellar-Partida, Gabriel, Ong, Jue-Sheng, An, Jiyuan, Gordon, Scott D., Zhu, Gu, MacGregor, Stuart, Lawlor, Deborah A., Breslin, Paul A. S., Wright, Margaret J., Martin, Nicholas G. and Reed, Danielle R. (2019). New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances. The American Journal of Clinical Nutrition, 109 (6), 1724-1737. doi: 10.1093/ajcn/nqz043
Associations between brain structure and perceived intensity of sweet and bitter tastes
Hwang, Liang-Dar, Strike, Lachlan T, Couvy-Duchesne, Baptiste, de Zubicaray, Greig I, McMahon, Katie, Breslin, Paul A. S., Reed, Danielle R., Martin, Nicholas G. and Wright, Margaret J. (2019). Associations between brain structure and perceived intensity of sweet and bitter tastes. Behavioural Brain Research, 363, 103-108. doi: 10.1016/j.bbr.2019.01.046
Evans, David M., Moen, Gunn-Helen, Hwang, Liang-Dar, Lawlor, Debbie A. and Warrington, Nicole M. (2019). Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization. International Journal of Epidemiology, 48 (3), 861-875. doi: 10.1093/ije/dyz019
Ong, Jue-Sheng, Hwang, Liang-Dar, Zhong, Victor W., An, Jiyuan, Gharahkhani, Puya, Breslin, Paul A. S., Wright, Margaret J., Lawlor, Deborah A., Whitfield, John, MacGregor, Stuart, Martin, Nicholas G. and Cornelis, Marilyn C. (2018). Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization. Scientific Reports, 8 (1) 16414, 16414. doi: 10.1038/s41598-018-34713-z
Hwang, Liang-Dar, Gharahkhani, Puya, Breslin, Paul A. S., Gordon, Scott D., Zhu, Gu, Martin, Nicholas G., Reed, Danielle R. and Wright, Margaret J. (2018). Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste. BMC Genomics, 19 (678) 678, 678. doi: 10.1186/s12864-018-5058-2
Ong, Jue-Sheng, Hwang, Liang-Dar, Cuellar-Partida, Gabriel, Martin, Nicholas G., Chenevix-Trench, Georgia, Quinn, Michael C. J., Cornelis, Marilyn C., Gharahkhani, Puya, Webb, Penelope M., MacGregor, Stuart and Ovarian Cancer Association Consortium (2017). Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study. International Journal of Epidemiology, 47 (2), 450-459. doi: 10.1093/ije/dyx236
Lipchock, Sarah V., Spielman, Andrew I., Mennella, Julie A., Mansfield, Corrine J., Hwang, Liang-Dar, Douglas, Jennifer E. and Reed, Danielle R. (2017). Caffeine bitterness is related to daily caffeine intake and bitter receptor mRNA abundance in human taste tissue. Perception, 46 (3-4), 245-256. doi: 10.1177/0301006616686098
Genetic analysis of impaired trimethylamine metabolism using whole exome sequencing
Guo, Yiran, Hwang, Liang-Dar, Li, Jiankang, Eades, Jason, Yu, Chung Wen, Mansfield, Corrine, Burdick-Will, Alexis, Chang, Xiao, Chen, Yulan, Duke, Fujiko F, Zhang, Jianguo, Fakharzadeh, Steven, Fennessey, Paul, Keating, Brendan J, Jiang, Hui, Hakonarson, Hakon, Reed, Danielle R and Preti, George (2017). Genetic analysis of impaired trimethylamine metabolism using whole exome sequencing. BMC Medical Genetics, 18 (1) 11. doi: 10.1186/s12881-017-0369-8
Is the association between sweet and bitter perception due to genetic variation?
Hwang, Liang-Dar, Breslin, Paul A. S., Reed, Danielle R., Zhu, Gu, Martin, Nicholas G. and Wright, Margaret J. (2016). Is the association between sweet and bitter perception due to genetic variation?. Chemical Senses, 41 (9), 737-744. doi: 10.1093/chemse/bjw083
Sweet taste perception is associated with body mass index at the phenotypic and genotypic level
Hwang, Liang-Dar, Cuellar-Partida, Gabriel, Ong, Jue-Sheng, Breslin, Paul A. S., Reed, Danielle R., Macgregor, Stuart, Gharahkhani, Puya, Martin, Nicholas G. and Renteria, Miguel E. (2016). Sweet taste perception is associated with body mass index at the phenotypic and genotypic level. Twin Research and Human Genetics, 19 (5), 465-471. doi: 10.1017/thg.2016.60
Cross sectional association between spatially measured walking bouts and neighborhood walkability
Hwang, Liang-Dar, Hurvitz, Philip M. and Duncan, Glen E. (2016). Cross sectional association between spatially measured walking bouts and neighborhood walkability. International Journal of Environmental Research and Public Health, 13 (4) 412, 1-11. doi: 10.3390/ijerph13040412
Hwang, Daniel (2016). Sugar cravings. Australasian Science, 37 (2), 14-16.
A common genetic influence on human intensity ratings of sugars and high-potency sweeteners
Hwang, Liang-Dar, Zhu, Gu, Breslin, Paul A. S., Reed, Danielle R., Martin, Nicholas G. and Wright, Margaret J. (2015). A common genetic influence on human intensity ratings of sugars and high-potency sweeteners. Twin Research and Human Genetics, 18 (4), 361-367. doi: 10.1017/thg.2015.42
Preferences for salty and sweet tastes are elevated and related to each other during childhood
Mennella, Julie A. , Finkbeiner, Susana , Lipchock, Sarah V. , Hwang, Liang-Dar and Reed, Danielle R. (2014). Preferences for salty and sweet tastes are elevated and related to each other during childhood. PLOS ONE, 9 (3) e92201, e92201. doi: 10.1371/journal.pone.0092201
Genetic analysis of chemosensory traits in human twins
Knaapila, Antti , Hwang, Liang-Dar , Lysenko, Anna , Duke, Fujiko F., Fesi, Brad , Khoshnevisan, Amin , James, Rebecca S. , Wysocki, Charles J., Rhyu, MeeRa , Tordoff, Michael G. , Bachmanov, Alexander A., Mura, Emi , Nagai, Hajime and Reed, Danielle R. (2012). Genetic analysis of chemosensory traits in human twins. Chemical Senses, 37 (9), 869-881. doi: 10.1093/chemse/bjs070
Ryoo, M., Hwang, D., Wright, O., Brown, J. and Roura, E. (2023). Consumption of diets rich in animal protein, saturated fat, or sodium, and low in fibre are associated with increased risk of acute appendicitis. 46th Annual Scientific Meeting of the Nutrition Society of Australia, Perth, WA Australia, 29 November – 2 December 2022. Cambridge, United Kingdom: Cambridge University Press. doi: 10.1017/s0029665123001258
Ryoo, M., Hwang, D., Wright, O., Brown, J. and Roura, E. (2023). Increased risk of acute appendicitis linked to biological sex, ethnic background, obesity, and smoking status. 46th Annual Scientific Meeting of the Nutrition Society of Australia, Perth, WA Australia, 29 November – 2 December 2022. Cambridge, United Kingdom: Cambridge University Press. doi: 10.1017/s0029665123001714
Complex-Traits Genetics Virtual Lab: A community-driven web platform for post-GWAS analyses
Cuéllar-Partida, Gabriel, Lundberg, Mischa, Campos-González, Adrian I., Kho, Pik Fang, D’Urso, Shannon, Hwang, Liang-Dar, Ngo, Trung Thanh and Rentería, Miguel E. (2019). Complex-Traits Genetics Virtual Lab: A community-driven web platform for post-GWAS analyses. American Society of Human Genetics (ASHG) 69th Annual Meeting, Houston, TX United States, 15–19 October 2019.
Genetic epidemiology of back pain: Examining causality with Complex Traits Virtual Lab
Ngo, Trung Thanh, Lundberg, Mischa, Campos-González, Adrian, Kho, Pik Fang, D’Urso, Shannon, Hwang, Liang-Dar, Rentería, Miguel and Cuéllar-Partida, Gabriel (2019). Genetic epidemiology of back pain: Examining causality with Complex Traits Virtual Lab. Australasian Epidemiological Association 2019 Annual Scientific Meeting — 'Epidemiology in the real world', South Brisbane, QLD Australia, 23–25 October 2019.
Evans, David, Warrington, Nicole, Partida, Gabriel Cuellar and Hwang, Daniel (2019). Using Mendelian randomization to estimate the causal effect of maternal (intrauterine) exposures on late onset offspring outcomes. 49th Annual Meeting of the Behavior Genetics Association (BGA), Stockholm, Sweden, 26-29 June, 2019. New York, NY, United States: Springer New York LLC. doi: 10.1007/s10519-019-09973-8
Long, Elizabeth, Ong, Jue-Sheng, Hwang, Liang-Dar, Savage, Jeanne E., Edwards, Alexis, Prom-Wormley, Elizabeth, Salvatore, Jessica E., Kendler, Kenneth S., Vassileva, Jasmin and Gillespie, Nathan A. (2018). F271. The Moderating Roles of Parental Monitoring and Peer Group Deviance on Polygenic Risk for Alcohol Use Across Adolescence. 2018 Annual Meeting of the Society of Biological Psychiatry, New York, United States, 10-12 May 2018. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.biopsych.2018.02.885
Replication and discovery of genetic variants influencing human bitter taste perception
Hwang, Liang-Dar, Gharahkhani, Puya, Zhu, Gu, Gordon, Scott D., Breslin, Paul A. S., Martin, Nicholas G., Reed, Danielle R. and Wright, Margaret J. (2018). Replication and discovery of genetic variants influencing human bitter taste perception. 39th Annual Meeting of the Association for Chemoreception Sciences, Bonita Springs, FL, United States, 26 - 29 April 2017. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/chemse/bjy003
Is the Association between Sweet and Bitter Perception due to Genetics?
Hwang, Liang-Dar, Breslin, Paul A., Reed, Danielle R., Zhu, Gu, Martin, Nicholas G. and Wright, Margaret J. (2016). Is the Association between Sweet and Bitter Perception due to Genetics?. 38th Annual Meeting of the Association-for-Chemoreception-Sciences (AChemS), Bonita Springs Fl, Apr 20-23, 2016. OXFORD: OXFORD UNIV PRESS.
GWAS of bitter taste perception in Australian adolescents
Hwang, Liang-Dar, Reed, Danielle, Breslin, Paul, Zhu, Gu, Martin, Nicholas and Wright, Margaret (2016). GWAS of bitter taste perception in Australian adolescents. 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane Australia, 20-23 June 2016. New York, NY, United States: Springer.
The Molecular Basis of Individual Differences in the Taste of an HIV Treatment Drug
Mennella, Julie A., Lowenthal, Elizabeth D., Mathew, Phoebe, Roberts, Kristi, Mansfield, Corrine, Hwang, Liang-Dar, Lin, Cailu and Reed, Danielle R. (2016). The Molecular Basis of Individual Differences in the Taste of an HIV Treatment Drug. 38th Annual Meeting of the Association-for-Chemoreception-Sciences (AChemS), Bonita Springs, Fl United States, 20-23 April 2016. Oxford, United Kingdom: Oxford University Press.
Epigenetics of the human TAS2R38 gene
Reed, Danielle R., Lipchock, Sarah V., Evans, Emily, Mansfield, Corrine, Hwang, Liang-Dar, Spielman, Andrew and Mennella, Julie A. (2015). Epigenetics of the human TAS2R38 gene. 37th Annual Meeting of the Association-for-Chemoreception-Sciences (AChemS), Bonita Spring, FL, United States, 22-25 April 2015. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/chemse/bjv029
Genetic Modeling of Human Intensity Ratings of Four Sweeteners
Hwang, Liang-Dar, Zhu, Gu, Wright, Margaret J., Martin, Nicholas G., Reed, Danielle R. and Breslin, Paul A. S. (2015). Genetic Modeling of Human Intensity Ratings of Four Sweeteners. 15th Scientific Meeting of the Australasian Association for ChemoSensory Science (AACSS), Brisbane, QLD Australia, 03-05 December 2014. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/chemse/bjv008
Hwang, Liang-Dar (Daniel) (2018). Individual differences in taste and their association with genes, dietary behaviour, and brain structure. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2018.573
Causal relationship between taste and smell perception and eating behaviour
(2024–2027) ARC Discovery Early Career Researcher Award
Dietary patterns and molecular mechanisms associated with the pathogenicity of appendicitis in humans
Doctor Philosophy — Associate Advisor
Other advisors:
Multi-omic Approaches to Understanding Septic Shock
Doctor Philosophy — Associate Advisor
Other advisors:
Using Genetics to Investigate Maternal Pregnancy Exposures and the Fetal Origins of Mental Health Outcomes
Doctor Philosophy — Associate Advisor
Other advisors:
(2023) Doctor Philosophy — Associate Advisor
Other advisors:
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
Develop novel approaches for personalised nutrition using large-scale genetically informative data
Polygenic risk scores have provided informative predictions for highly heritable traits and has been intergrated into risk prediction models along with traditional clinicial measurements to improvde risk prediction of cardiometabolic disease and other inherited health conditions. This project aims to develop novel polygenic scores specifically for priotising interventions or "personalised intervention" rather than risk prediction.
Impact of COVID-19 vaccinations on long-COVID symptoms
This project aims to investigate post-vaccination changes in the perception of smell and taste and other symptoms of long-COVID using data collected from the Global Consortium for Chemosensory Research (https://gcchemosensr.org/). The results will help assess the potential impact of COVID-19 vaccines and provide new clues to help us understand recovery from long-COVID.
Supertaster gene and picky eating
This study will involve collecting genetic, dietary, and sensory data from young children and their parents to perform a comprehensive analysis to understand factors contributing to picking eating behaviour in young children.