Journal Article: A general strategy for direct growth of yolk-shell MOF-on-MOF hybrids
Li, Jiaxin, Bao, Tong, Zhang, Chaoqi, Song, Hao, Zou, Yingying, Yuan, Ling, Xi, Yamin, Yu, Chengzhong and Liu, Chao (2023). A general strategy for direct growth of yolk-shell MOF-on-MOF hybrids. Chemical Engineering Journal, 472 144926, 1-9. doi: 10.1016/j.cej.2023.144926
Journal Article: Engineering nanoparticle toolkits for mRNA delivery
Sun, Bing, Wu, Weixi, Narasipura, Eshan A., Ma, Yutian, Yu, Chengzhong, Fenton, Owen S. and Song, Hao (2023). Engineering nanoparticle toolkits for mRNA delivery. Advanced Drug Delivery Reviews, 200 115042, 115042. doi: 10.1016/j.addr.2023.115042
Journal Article: Scalable manufacturing of enzyme loaded alginate particles with excellent thermal and storage stability for industrial applications
Weng, Yilun, Wan, Andria, Li, Yang, Liu, Yun, Chen, Xiaojing, Song, Hao and Zhao, Chun-Xia (2023). Scalable manufacturing of enzyme loaded alginate particles with excellent thermal and storage stability for industrial applications. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 667 131412, 1-10. doi: 10.1016/j.colsurfa.2023.131412
Bio-inspired Nanoparticles for Next-generation Shelf-stable mRNA Vaccines
(2023) UQ Foundation Research Excellence Awards
A Long-Lasting Oral Drug Delivery System Using Spiky Silica Nanoparticles
(2021–2025) NHMRC Investigator Grants
Development of a market relevant DNA nano-vaccine platform
(2021–2025) ARC Linkage Projects
clinically-oriented synergized immunotherapy strategies for breast cancer
Doctor Philosophy
Biomimetic Nanoparticles for Efficient Vaccine Delivery
Doctor Philosophy
Engineering Spiky Nanoparticles Probed at the Nano-Bio Interfaces
Doctor Philosophy
A nanotechnology for long-lasting oral drug delivery.
Medication adherence is required for the effectiveness of all pharmacotherapies, especially for long-term treatment of chronic illness and infectious diseases such as malaria, diabetes, and HIV. However, intensive dosage regimens with a high pill burden are associated with a low adherence rate, leading to compromised or even failure of therapies. My project aims to realize the ideal of ‘pillbox in a capsule’, i.e. taking a single tablet that will provide sustained drug release over several days, by developing a long-lasting oral drug delivery platform with prolonged gastrointestinal transit time. Inspired by bio-adhesive natural systems, where spiky surfaces enable strong adhesion, this project will engineer silica particles with a spiky morphology as well as their assembled medical devices as oral drug delivery vehicles, and their interactions at the bio-interfaces in the gastrointestinal environment will be investigated in detail. On completion, this project will produce guidelines for the rational design of novel oral drug delivery systems, and new potential clinical strategies for simplified oral medications to improve medication adherence and patient outcomes.
Virus-mimicking nanoparticles for DNA vaccine
DNA vaccine, as the third generation vaccine technology, representing the latest biotechnological breakthrough in vaccine development. Compared to conventional recombinant vaccines usually only stimulating the antibody responses, DNA vaccine show advantages in evoking both cellular and humoral immunity to fulfill the demand in combating chronic infectious diseases. Moreover, the cost-effectiveness and fast speed of production make DNA vaccine an ideal strategy to deal with outbreaks such as SARS-COV-2 and H5N1 for the sake of both public and animal healthcare. To enable a successful DNA vaccine technology, it is critical to develop efficient gene vectors to transport and regulate the DNA molecules to be highly expressed in target cells. Mimicking the morphology of the virus, this project aims to fabricate a series of virus-like silica nanoparticles with tailored physicochemical features for plasmid DNA delivery and investigate their gene translation and vaccine performance. The completion of this project will provide fundamental understandings of the impact of designer particle nanostructure/chemistry on DNA transfection and vaccine immunogenicity.
Nature-inspired spiky nanomaterials probed at the bio-nano interfaces
The intriguing nature systems have inspired remarkable advances in the development of functional nanomaterials for biomedical applications. Nature creations such as pollen grains and virus with spiky topological features at various length scales enable multivalent interactions at bio-interfaces, and typically exhibit intriguing surface adhesive property. This project aims to apply this nature-derived principle to engineer nanoparticles for enhanced intracellular delivery of biomolecules. Nanomaterials with functional compositions and tailored spiky nanostructures will be fabricated. Their cellular internalization process and biomolecules delivery efficiency will be evaluated. On completion of this project, a versatile and functional drug delivery platform will be established and an in-depth understanding of the spiky nanoparticle-cell interaction will be revealed.
A general strategy for direct growth of yolk-shell MOF-on-MOF hybrids
Li, Jiaxin, Bao, Tong, Zhang, Chaoqi, Song, Hao, Zou, Yingying, Yuan, Ling, Xi, Yamin, Yu, Chengzhong and Liu, Chao (2023). A general strategy for direct growth of yolk-shell MOF-on-MOF hybrids. Chemical Engineering Journal, 472 144926, 1-9. doi: 10.1016/j.cej.2023.144926
Engineering nanoparticle toolkits for mRNA delivery
Sun, Bing, Wu, Weixi, Narasipura, Eshan A., Ma, Yutian, Yu, Chengzhong, Fenton, Owen S. and Song, Hao (2023). Engineering nanoparticle toolkits for mRNA delivery. Advanced Drug Delivery Reviews, 200 115042, 115042. doi: 10.1016/j.addr.2023.115042
Weng, Yilun, Wan, Andria, Li, Yang, Liu, Yun, Chen, Xiaojing, Song, Hao and Zhao, Chun-Xia (2023). Scalable manufacturing of enzyme loaded alginate particles with excellent thermal and storage stability for industrial applications. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 667 131412, 1-10. doi: 10.1016/j.colsurfa.2023.131412
Spatial specific Janus s‐scheme photocatalyst with enhanced H2 O2 production performance
Xia, Chunhong, Yuan, Ling, Song, Hao, Zhang, Chaoqi, Li, Zimeng, Zou, Yingying, Li, Jiaxin, Bao, Tong, Yu, Chengzhong and Liu, Chao (2023). Spatial specific Janus s‐scheme photocatalyst with enhanced H2 O2 production performance. Small, 19 (29) e2300292. doi: 10.1002/smll.202300292
Improved enzyme thermal stability, loading and bioavailability using alginate encapsulation
Weng, Yilun, Ranaweera, Supun, Zou, Da, Cameron, Anna, Chen, Xiaojing, Song, Hao and Zhao, Chun-Xia (2023). Improved enzyme thermal stability, loading and bioavailability using alginate encapsulation. Food Hydrocolloids, 137 108385, 1-13. doi: 10.1016/j.foodhyd.2022.108385
Encapsulation of enzymes in food industry using spray drying: recent advances and process scale-ups
Weng, Yilun, Li, Yang, Chen, Xiaojing, Song, Hao and Zhao, Chun-Xia (2023). Encapsulation of enzymes in food industry using spray drying: recent advances and process scale-ups. Critical Reviews in Food Science and Nutrition, 1-18. doi: 10.1080/10408398.2023.2193982
Bioengineered materials with selective antimicrobial toxicity in biomedicine
Makvandi, Pooyan, Song, Hao, Yiu, Cynthia K. Y., Sartorius, Rossella, Zare, Ehsan Nazarzadeh, Rabiee, Navid, Wu, Wei-Xi, Paiva-Santos, Ana Cláudia, Wang, Xiang-Dong, Yu, Cheng-Zhong and Tay, Franklin R. (2023). Bioengineered materials with selective antimicrobial toxicity in biomedicine. Military Medical Research, 10 (1) 8, 1-20. doi: 10.1186/s40779-023-00443-1
Cheng, Dan, Theivendran, Shevanuja, Tang, Jie, Cai, Larry, Zhang, Jun, Song, Hao and Yu, Chengzhong (2022). Surface chemistry of spiky silica nanoparticles tailors polyethyleneimine binding and intracellular DNA delivery. Journal of Colloid and Interface Science, 628 (Part B), 297-305. doi: 10.1016/j.jcis.2022.08.038
Tang, Jie, Yang, Yang, Qu, Jingjing, Ban, Wenhuang, Song, Hao, Gu, Zhengying, Yang, Yannan, Cai, Larry, Theivendran, Shevanuja, Wang, Yue, Zhang, Min and Yu, Chengzhong (2022). Mesoporous sodium four-coordinate aluminosilicate nanoparticles modulate dendritic cell pyroptosis and activate innate and adaptive immunity. Chemical Science, 13 (29), 8507-8517. doi: 10.1039/d1sc05319a
Theivendran, Shevanuja, Gu, Zhengying, Tang, Jie, Yang, Yannan, Song, Hao, Yang, Yang, Zhang, Min, Cheng, Dan and Yu, Chengzhong (2022). Nanostructured organosilica nitric oxide donors intrinsically regulate macrophage polarization with antitumor effect. ACS Nano, 16 (7), 10943-10957. doi: 10.1021/acsnano.2c03348
Alginate particles for enzyme immobilization using spray drying
Weng, Yilun, Ranaweera, Supun, Zou, Da, Cameron, Anna, Chen, Xiaojing, Song, Hao and Zhao, Chun-Xia (2022). Alginate particles for enzyme immobilization using spray drying. Journal of Agricultural and Food Chemistry, 70 (23), 7139-7147. doi: 10.1021/acs.jafc.2c02298
Pore architecture influences the enzyme immobilization performance of mesoporous silica nanospheres
Kothalawala, Sukitha Geethma, Jiao, Jinqing, Speight, Robert, Song, Hao, Yang, Yannan and Zhang, Jun (2022). Pore architecture influences the enzyme immobilization performance of mesoporous silica nanospheres. Microporous and Mesoporous Materials, 338 111963, 111963. doi: 10.1016/j.micromeso.2022.111963
Ni, Chengang, Zhong, Yuening, Wu, Weixi, Song, Yaping, Makvandi, Pooyan, Yu, Chengzhong and Song, Hao (2022). Co-Delivery of Nano-Silver and Vancomycin via Silica Nanopollens for Enhanced Antibacterial Functions. Antibiotics, 11 (5) 685, 1-11. doi: 10.3390/antibiotics11050685
Gao, Fang, Liu, Chao, Yao, Yining, Lei, Chang, Li, Shumin, Yuan, Ling, Song, Hao, Yang, Yannan, Wan, Jingjing and Yu, Chengzhong (2022). Quantum dots’ size matters for balancing their quantity and quality in label materials to improve lateral flow immunoassay performance for C-Reactive protein determination. Biosensors and Bioelectronics, 199 113892, 113892. doi: 10.1016/j.bios.2021.113892
Sharifi, Esmaeel, Bigham, Ashkan, Yousefiasl, Satar, Trovato, Maria, Ghomi, Matineh, Esmaeili, Yasaman, Samadi, Pouria, Zarrabi, Ali, Ashrafizadeh, Milad, Sharifi, Shokrollah, Sartorius, Rossella, Dabbagh Moghaddam, Farnaz, Maleki, Aziz, Song, Hao, Agarwal, Tarun, Maiti, Tapas Kumar, Nikfarjam, Nasser, Burvill, Colin, Mattoli, Virgilio, Raucci, Maria Grazia, Zheng, Kai, Boccaccini, Aldo R., Ambrosio, Luigi and Makvandi, Pooyan (2022). Mesoporous bioactive glasses in cancer diagnosis and therapy: stimuli-responsive, toxicity, immunogenicity, and clinical translation. Advanced Science, 9 (2) 2102678, e2102678. doi: 10.1002/advs.202102678
Tailoring head–tail mesoporous silica nanoparticles for enhanced gene transfection
Wu, Weixi, Ngo, Anh, Ban, Wenhuang, Zhong, Yuening, Cheng, Dan, Gu, Zhengying, Yu, Chengzhong and Song, Hao (2022). Tailoring head–tail mesoporous silica nanoparticles for enhanced gene transfection. Journal of Materials Chemistry B, 10 (39), 7995-8002. doi: 10.1039/d2tb01737g
Lin, Xiuzhen, Wu, Weixi, Fu, Jianye, Yang, Yannan, Guo, Bing, Yu, Chengzhong and Song, Hao (2021). Asymmetric silica nanoparticles with tailored spiky coverage derived from silica–polymer cooperative assembly for enhanced hemocompatibility and gene delivery. ACS Applied Materials and Interfaces, 13 (43), 50695-50704. doi: 10.1021/acsami.1c13517
Cao, Yuxue, Xu, Chun, Wright, Patricia P., Liu, Jingyu, Kong, Yueqi, Wang, Yue, Huang, Xiaodan, Song, Hao, Fu, Jianye, Gao, Fang, Liu, Yang, Walsh, Laurence J. and Lei, Chang (2021). Calcium-doped silica nanoparticles mixed with phosphate-doped silica nanoparticles for rapid and stable occlusion of dentin tubules. ACS Applied Nano Materials, 4 (9) acsanm.1c01365, 8761-8769. doi: 10.1021/acsanm.1c01365
Fu, Jianye, Jiao, Jinqing, Ban, Wenhuang, Kong, Yueqi, Gu, Zhengying, Song, Hao, Huang, Xiaodan, Yang, Yannan and Yu, Chengzhong (2021). Large scale synthesis of self-assembled shuttlecock-shaped silica nanoparticles with minimized drag as advanced catalytic nanomotors. Chemical Engineering Journal, 417 127971, 1-7. doi: 10.1016/j.cej.2020.127971
Gu, Zhengying, Liu, Tianqing, Liu, Chao, Yang, Yannan, Tang, Jie, Song, Hao, Wang, Yue, Yang, Yang and Yu, Chengzhong (2021). Ferroptosis-strengthened metabolic and inflammatory regulation of tumor-associated macrophages provokes potent tumoricidal activities. Nano Letters, 21 (15) acs.nanolett.1c01401, 6471-6479. doi: 10.1021/acs.nanolett.1c01401
Gao, Fang, Lei, Chang, Liu, Yang, Song, Hao, Kong, Yueqi, Wan, Jingjing and Yu, Chengzhong (2021). Rational design of dendritic mesoporous silica nanoparticles’ surface chemistry for quantum dot enrichment and an ultrasensitive lateral flow immunoassay. ACS Applied Materials and Interfaces, 13 (18) acsami.1c02149, 21507-21515. doi: 10.1021/acsami.1c02149
Gao, Fang, Liu, Yang, Lei, Chang, Liu, Chao, Song, Hao, Gu, Zhengying, Jiang, Pei, Jing, Sheng, Wan, Jingjing and Yu, Chengzhong (2021). The role of dendritic mesoporous silica nanoparticles' size for quantum dots enrichment and lateral flow immunoassay performance. Small Methods, 5 (4) 2000924, e2000924. doi: 10.1002/smtd.202000924
Nanotechnology enabled reactive species regulation in biosystems for boosting cancer immunotherapy
Zhang, Min, Dai, Zan, Theivendran, Shevanuja, Gu, Zhengying, Zhao, Liang, Song, Hao, Yang, Yannan and Yu, Chengzhong (2021). Nanotechnology enabled reactive species regulation in biosystems for boosting cancer immunotherapy. Nano Today, 36 101035, 1-18. doi: 10.1016/j.nantod.2020.101035
Rambutan-like silica nanoparticles at tailored particle sizes for plasmid DNA delivery
Hines, Elizabeth, Cheng, Dan, Wu, Weixi, Yu, Meihua, Xu, Chun, Song, Hao and Yu, Chengzhong (2021). Rambutan-like silica nanoparticles at tailored particle sizes for plasmid DNA delivery. Journal of Materials Science, 56 (9), 5830-5844. doi: 10.1007/s10853-020-05660-w
Tang, Jie, Meka, Anand Kumar, Theivendran, Shevanuja, Wang, Yue, Yang, Yannan, Song, Hao, Fu, Jianye, Ban, Wenhuang, Gu, Zhengying, Lei, Chang, Li, Shumin and Yu, Chengzhong (2020). Openwork@Dendritic mesoporous silica nanoparticles for lactate depletion and tumor microenvironment regulation. Angewandte Chemie International Edition, 59 (49) anie.202001469, 22054-22062. doi: 10.1002/anie.202001469
Wang, Yue, Song, Hao, Liu, Chao, Zhang, Ye, Kong, Yueqi, Tang, Jie, Yang, Yannan and Yu, Chengzhong (2020). Confined growth of ZIF-8 in dendritic mesoporous organosilica nanoparticles as bio-regulators for enhanced mRNA delivery in vivo. National Science Review, 8 (8) nwaa268, 1-10. doi: 10.1093/nsr/nwaa268
Silica-based nanoparticles for biomedical applications: from nanocarriers to biomodulators
Yang, Yannan, Zhang, Min, Song, Hao and Yu, Chengzhong (2020). Silica-based nanoparticles for biomedical applications: from nanocarriers to biomodulators. Accounts of Chemical Research, 53 (8) acs.accounts.0c00280, 1545-1556. doi: 10.1021/acs.accounts.0c00280
Yu, Rongtai, Huang, Xiaodan, Liu, Yang, Kong, Yueqi, Gu, Zhengying, Yang, Yang, Wang, Yue, Ban, Wenhuang, Song, Hao and Yu, Chengzhong (2020). Shaping nanoparticles for interface catalysis: concave hollow spheres via deflation–inflation asymmetric growth. Advanced Science, 7 (13) 2000393, 2000393. doi: 10.1002/advs.202000393
Geng, Jing, Song, Hao, Gao, Fang, Kong, Yueqi, Fu, Jianye, Luo, Jiangqi, Yang, Yannan and Yu, Chengzhong (2020). Lyophilization enabled disentanglement of polyethylenimine on rambutan-like silica nanoparticles for enhanced plasmid DNA delivery. Journal of Materials Chemistry B, 8 (21), 4593-4600. doi: 10.1039/d0tb00720j
Wang, Yue, Tang, Jie, Yang, Yannan, Song, Hao, Fu, Jianye, Gu, Zhengying and Yu, Chengzhong (2020). Functional nanoparticles with a reducible tetrasulfide motif to upregulate mRNA translation and enhance transfection in hard-to-transfect cells. Angewandte Chemie International Edition, 132 (7) ange.201914264, 2717-2721. doi: 10.1002/anie.201914264
Song, Hao, Hewitt, Olivia H. and Degnan, Sandie M. (2020). Arginine biosynthesis by a bacterial symbiont enables nitric oxide production and facilitates larval settlement in the marine-sponge host. Current Biology, 31 (2), 433-437.e3. doi: 10.1016/j.cub.2020.10.051
Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment
Theivendran, Shevanuja, Tang, Jie, Lei, Chang, Yang, Yannan, Song, Hao, Gu, Zhengying, Wang, Yue, Yang, Yang, Jin, Lei and Yu, Chengzhong (2020). Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment. Chemical Science, 11 (38), 10421-10430. doi: 10.1039/d0sc02803g
Fractal-in-a-sphere: confined self-assembly of fractal silica nanoparticles
Fu, Jianye, Jiao, Jinqing, Song, Hao, Gu, Zhengying, Liu, Yang, Geng, Jing, Jack, Kevin S., Du, Ai, Tang, Jie and Yu, Chengzhong (2019). Fractal-in-a-sphere: confined self-assembly of fractal silica nanoparticles. Chemistry of Materials, 32 (1) acs.chemmater.9b03864, 341-347. doi: 10.1021/acs.chemmater.9b03864
Wu, Chenghao, Song, Hao, Tang, Cheng, Du, Aijun, Yu, Chengzhong, Huang, Zhendong, Wu, Minghong and Zhang, Haijiao (2019). Ultralarge interlayer distance and C,N-codoping enable superior sodium storage capabilities of MoS2 nanoonions. Chemical Engineering Journal, 378 122249, 122249. doi: 10.1016/j.cej.2019.122249
Antibiotic‐free antibacterial strategies enabled by nanomaterials: progress and perspectives
Wang, Yue, Yang, Yannan, Shi, Yiru, Song, Hao and Yu, Chengzhong (2019). Antibiotic‐free antibacterial strategies enabled by nanomaterials: progress and perspectives. Advanced Materials, 32 (18) 1904106, 1904106. doi: 10.1002/adma.201904106
DNA vaccine mediated by rambutan‐like mesoporous silica nanoparticles
Song, Hao, Yang, Yannan, Tang, Jie, Gu, Zhengying, Wang, Yue, Zhang, Min and Yu, Chengzhong (2019). DNA vaccine mediated by rambutan‐like mesoporous silica nanoparticles. Advanced Therapeutics, 3 (1) 1900154, 1900154. doi: 10.1002/adtp.201900154
Kong, Yueqi, Nanjundan, Ashok Kumar, Liu, Yang, Song, Hao, Huang, Xiaodan and Yu, Chengzhong (2019). Modulating ion diffusivity and electrode conductivity of carbon nanotube@mesoporous carbon fibers for high performance aluminum-selenium batteries. Small, 15 (51) 1904310, e1904310. doi: 10.1002/smll.201904310
Yang, Yannan, Tang, Jie, Zhang, Min, Gu, Zhengying, Song, Hao, Yang, Yang and Yu, Chengzhong (2019). Responsively aggregatable sub-6 nm nanochelators induce simultaneous antiangiogenesis and vascular obstruction for enhanced tumor vasculature targeted therapy. Nano Letters, 19 (11), 7750-7759. doi: 10.1021/acs.nanolett.9b02691
Li, Huimin, Guo, Huilin, Lei, Chang, Liu, Li, Xu, Liqin, Feng, Yaping, Ke, Jin, Fang, Wei, Song, Hao, Xu, Chun, Yu, Chengzhong and Long, Xing (2019). Nanotherapy in joints: increasing endogenous hyaluronan production by delivering hyaluronan synthase 2. Advanced Materials, 31 (46) 1904535, 1904535. doi: 10.1002/adma.201904535
Electron tomography: a unique tool solving intricate hollow nanostructures
Song, Hao, Yang, Yannan, Geng, Jing, Gu, Zhengying, Zou, Jin and Yu, Chengzhong (2019). Electron tomography: a unique tool solving intricate hollow nanostructures. Advanced Materials, 31 (38) 1801564, 1801564. doi: 10.1002/adma.201801564
Heterogeneous contraction-mediated asymmetric carbon colloids
Liu, Zhenhui, Song, Hao, Zhao, Yunlong, He, Ruhan, Meng, Jiashen, Yu, Qiang, Owusu, Kwadwo Asare, Yu, Chengzhong, Zhao, Dongyuan, Zhou, Liang and Mai, Liqiang (2019). Heterogeneous contraction-mediated asymmetric carbon colloids. ACS Materials Letters, 1 (3), 290-296. doi: 10.1021/acsmaterialslett.9b00179
Gu, Zhengying, Liu, Tianqing, Tang, Jie, Yang, Yannan, Song, Hao, Tuong, Zewen K., Fu, Jianye and Yu, Chengzhong (2019). Mechanism of iron oxide-induced macrophage activation: the impact of composition and the underlying signaling pathway. Journal of the American Chemical Society, 141 (15) jacs.8b10904, 6122-6126. doi: 10.1021/jacs.8b10904
Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations
Fu, Jianye, Gu, Zhengying, Liu, Yang, Zhang, Jun, Song, Hao, Yang, Yannan, Yang, Yang, Noonan, Owen, Tang, Jie and Yu, Chengzhong (2019). Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations. Chemical Science, 10 (44), 10388-10394. doi: 10.1039/c9sc02961c
Zhang, Wuxiang, Song, Hao, Cheng, Yan, Liu, Chao, Wang, Chaohai, Khan, Muhammad Abdul Nasir, Zhang, Hao, Liu, Jizi, Yu, Chengzhong, Wang, Lianjun and Li, Jiansheng (2019). Core–shell Prussian blue analogs with compositional heterogeneity and open cages for oxygen evolution reaction. Advanced Science, 6 (7) 1801901, 1801901. doi: 10.1002/advs.201801901
Kalantari, Mohammad, Liu, Yang, Strounina, Ekaterina, Yang, Yannan, Song, Hao and Yu, Chengzhong (2018). Superhydrophobic dendritic mesoporous organosilica nano-particles with ultrahigh-content of gradient organic moieties. Journal of Materials Chemistry A, 6 (36), 17579-17586. doi: 10.1039/c8ta06268d
Yang, Yannan, Tang, Jie, Abbaraju, Prasanna Lakshmi, Jambhrunkar, Manasi, Song, Hao, Zhang, Min, Lei, Chang, Fu, Jianye, Gu, Zhengying, Liu, Yang and Yu, Chengzhong (2018). Hybrid nanoreactors: enabling an off-the-shelf strategy for concurrently enhanced chemo-immunotherapy. Angewandte Chemie, 130 (36), 11938-11943. doi: 10.1002/ange.201807595
Wang, Yue, Song, Hao, Yang, Yannan, Liu, Yang, Tang, Jie and Yu, Chengzhong (2018). Kinetically controlled dendritic mesoporous silica nanoparticles: from dahlia- to pomegranate-like structures by micelle filling. Chemistry of Materials, 30 (16) acs.chemmater.8b02712, 5770-5776. doi: 10.1021/acs.chemmater.8b02712
Lu, Yao, Yang, Yannan, Gu, Zhengying, Zhang, Jun, Song, Hao, Xiang, Guangya and Yu, Chengzhong (2018). Glutathione-depletion mesoporous organosilica nanoparticles as a self-adjuvant and Co-delivery platform for enhanced cancer immunotherapy. Biomaterials, 175, 82-92. doi: 10.1016/j.biomaterials.2018.05.025
Hybrid nanoreactors enable an off-the-shelf strategy for concurrently enhanced chemo-immunotherapy
Yang, Yannan, Tang, Jie, Abbaraju, Prasanna Lakshmi, Jambhrunkar, Manasi, Song, Hao, Zhang, Min, Lei, Chang, Fu, Jianye, Gu, Zhengying, Liu, Yang and Yu, Chengzhong (2018). Hybrid nanoreactors enable an off-the-shelf strategy for concurrently enhanced chemo-immunotherapy. Angewandte Chemie, 57 (36), 11764-11769. doi: 10.1002/anie.201807595
Oxidative dissolution of resoles: a versatile approach to intricate nanostructures
Zhang, Min, Song, Hao, Yang, Yannan, Huang, Xiaodan, Liu, Yang, Liu, Chao and Yu, Chengzhong (2018). Oxidative dissolution of resoles: a versatile approach to intricate nanostructures. Angewandte Chemie - International Edition, 56 (3), 654-658. doi: 10.1002/anie.201709591
Wang, Yue, Song, Hao, Yu, Meihua, Xu, Chun, Liu, Yang, Tang, Jie, Yang, Yannan and Yu, Chengzhong (2018). Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance. Journal of Materials Chemistry B, 6 (24), 4089-4095. doi: 10.1039/c8tb00544c
Purwajanti, Swasmi, Huang, Xiaodan, Liu, Yang, Yang, Yannan, Noonan, Owen, Song, Hao, Zhang, Jun, Zhang, Jing, Fu, Jianye, Liang, Changhao and Yu, Chengzhong (2017). Mg(OH)(2)-MgO@reduced graphene oxide nanocomposites: the roles of composition and nanostructure in arsenite sorption. Journal of Materials Chemistry a, 5 (46), 24484-24492. doi: 10.1039/c7ta07629k
Liu, Chao, Huang, Xiaodan, Wang, Jing, Song, Hao, Yang, Yannan, Liu, Yang, Li, Jiansheng, Wang, Lianjun and Yu, Chengzhong (2017). Hollow Mesoporous Carbon Nanocubes: Rigid-Interface-Induced Outward Contraction of Metal-Organic Frameworks. Advanced Functional Materials, 28 (6) 1705253, 1705253. doi: 10.1002/adfm.201705253
Jiao, Jinqing, Fu, Jianye, Wei, Yuechang, Zhao, Zhen, Duan, Aijun, Xu, Chunming, Li, Jianmei, Song, Hao, Zheng, Peng, Wang, Xilong, Yang, Yannan and Liu, Yang (2017). Al-modified dendritic mesoporous silica nanospheres-supported NiMo catalysts for the hydrodesulfurization of dibenzothiophene: Efficient accessibility of active sites and suitable metal-support interaction. Journal of Catalysis, 356, 269-282. doi: 10.1016/j.jcat.2017.10.003
Plasmid DNA Delivery: Nanotopography Matters
Song, Hao, Yu, Meihua, Lu, Yao, Gu, Zhengying, Yang, Yannan, Zhang, Min, Fu, Jianye and Yu, Chengzhong (2017). Plasmid DNA Delivery: Nanotopography Matters. Journal of the American Chemical Society, 139 (50), 18247-18254. doi: 10.1021/jacs.7b08974
Liu, Yang, Zhang, Hongwei, Song, Hao, Noonan, Owen, Lang, Changhao, Huang, Xiaodan and Yu, Chengzhong (2017). Single-layered mesoporous carbon sandwiched graphene nanosheets for high performance ionic liquid supercapacitors. Journal of Physical Chemistry C, 121 (43), 23947-23954. doi: 10.1021/acs.jpcc.7b08777
Xu, Chun, Lei, Chang, Huang, Lili, Zhang, Jun, Zhang, Hongwei, Song, Hao, Yu, Meihua, Wu, Yeda, Chen, Chen and Yu, Chengzhong (2017). Glucose-responsive nanosystem mimicking the physiological insulin secretion via an enzyme-polymer layer-by-layer coating strategy. Chemistry of Materials, 29 (18), 7725-7732. doi: 10.1021/acs.chemmater.7b01804
Abbaraju, Prasanna Lakshmi, Meka, Anand Kumar, Song, Hao, Yang, Yannan, Jambhrunkar, Manasi, Zhang, Jun, Xu, Chun, Yu, Meihua and Yu, Chengzhong (2017). Asymmetric silica nanoparticles with tunable head-tail structures enhance hemocompatibility and maturation of immune cells. Journal of the American Chemical Society, 139 (18), 6321-6328. doi: 10.1021/jacs.6b12622
Tailoring mesoporous-silica nanoparticles for robust immobilization of lipase and biocatalysis
Kalantari, Mohammad, Yu, Meihua, Yang, Yannan, Strounina, Ekaterina, Gu, Zhengying, Huang, Xiaodan, Zhang, Jun, Song, Hao and Yu, Chengzhong (2017). Tailoring mesoporous-silica nanoparticles for robust immobilization of lipase and biocatalysis. Nano Research, 10 (2), 605-617. doi: 10.1007/s12274-016-1320-6
Kalantari, Mohammad, Yu, Meihua, Noonan, Owen, Song, Hao, Xu, Chun, Huang, Xiaodan, Xiang, Feixiang, Wang, Xiaolin and Yu, Chengzhong (2017). Rattle-type magnetic mesoporous hollow carbon as a high-performance and reusable adsorbent for water treatment. Chemosphere, 166, 109-117. doi: 10.1016/j.chemosphere.2016.09.083
Zhang, Hongwei, Zhou, Liang, Huang, Xiaodan, Song, Hao and Yu, Chengzhong (2016). Encapsulation of selenium sulfide in double-layered hollow carbon spheres as advanced electrode material for lithium storage. Nano Research, 9 (12), 3725-3734. doi: 10.1007/s12274-016-1243-2
Nor, Yusilawati Ahmad, Zhang, Hongwei, Purwajanti, Swasmi, Song, Hao, Meka, Anand Kumar, Wang, Yue, Mitter, Neena, Mahony, Donna and Yu, Chengzhong (2016). Hollow mesoporous carbon nanocarriers for vancomycin delivery: understanding the structure-release relationship for prolonged antibacterial performance. Journal of Materials Chemistry B, 4 (43), 7014-7021. doi: 10.1039/c6tb01778a
Purwajanti, Swasmi, Zhang, Hongwei, Huang, Xiaodan, Song, Hao, Yang, Yannan, Zhang, Jun, Niu, Yuting, Meka, Anand Kumar, Noonan, Owen and Yu, Chengzhong (2016). Mesoporous magnesium oxide hollow spheres as superior arsenite adsorbent: synthesis and adsorption behavior. ACS Applied Materials and Interfaces, 8 (38), 25306-25312. doi: 10.1021/acsami.6b08322
Noonan, Owen, Zhang, Hongwei, Song, Hao, Xu, Chun, Huang, Xiaodan and Yu, Chengzhong (2016). In situ Stöber templating: facile synthesis of hollow mesoporous carbon spheres from silica-polymer composites for ultra-high level in-cavity adsorption. Journal of Materials Chemistry A, 4 (23), 9063-9071. doi: 10.1039/c6ta02265k
Silica nanopollens enhance adhesion for long-term bacterial inhibition
Song, Hao, Ahmad Nor, Yusilawati, Yu, Meihua, Yang, Yannan, Zhang, Jun, Zhang, Hongwei, Xu, Chun, Mitter, Neena and Yu, Chengzhong (2016). Silica nanopollens enhance adhesion for long-term bacterial inhibition. Journal of the Americal Chemical Society, 138 (20), 6455-6462. doi: 10.1021/jacs.6b00243
Wang, Yue, Nor, Yusilawati Ahmad, Song, Hao, Yang, Yannan, Xu, Chun, Yu, Meihua and Yu, Chengzhong (2016). Small-sized and large-pore dendritic mesoporous silica nanoparticles enhance antimicrobial enzyme delivery. Journal of Materials Chemistry B, 4 (15), 2646-2653. doi: 10.1039/c6tb00053c
Yang, Yannan, Bernardi, Stefano, Song, Hao, Zhang, Jun, Yu, Meihua, Reid, James C., Strounina, Ekaterina, Searles, Debra J. and Yu, Chengzhong (2016). Anion assisted synthesis of large pore hollow dendritic mesoporous organosilica nanoparticles: understanding the composition gradient. Chemistry of Materials, 28 (3), 704-707. doi: 10.1021/acs.chemmater.5b03963
Wang, Yao, Song, Hao, Yu, Chengzhong and Gu, Hongchen (2016). From helixes to mesostructures: evolution of mesoporous silica shells on single-walled carbon nanotubes. Chemistry of Materials, 28 (3), 936-942. doi: 10.1021/acs.chemmater.5b04660
Xu, Chun, Yu, Meihua, Noonan, Owen, Zhang, Jun, Song, Hao, Zhang, Hongwei, Lei, Chang, Niu, Yuting, Huang, Xiaodan, Yang, Yannan and Yu, Chengzhong (2015). Core-cone structured monodispersed mesoporous silica nanoparticles with ultra-large cavity for protein delivery. Small, 11 (44), 5949-5955. doi: 10.1002/smll.201501449
Zhang, Hongwei, Yu, Meihua, Song, Hao, Noonan, Owen, Zhang, Jun, Yang, Yannan, Zhou, Liang and Yu, Chengzhong (2015). Self-Organized Mesostructured Hollow Carbon Nanoparticles via a Surfactant-Free Sequential Heterogeneous Nucleation Pathway. Chemistry of Materials, 27 (18), 6297-6304. doi: 10.1021/acs.chemmater.5b01993
Hierarchical SAPO-11 preparation in the presence of glucose
Liu, Zhen, Liu, Lingjing, Song, Hao, Wang, Chuangye, Xing, Wei, Kornarneni, Sridhar and Yan, Zifeng (2015). Hierarchical SAPO-11 preparation in the presence of glucose. Materials Letters, 154, 116-119. doi: 10.1016/j.matlet.2015.04.067
Yang, Yannan, Yu, Meihua, Song, Hao, Wang, Yue and Yu, Chengzhong (2015). Preparation of fluorescent mesoporous hollow silica-fullerene nanoparticles via selective etching for combined chemotherapy and photodynamic therapy. Nanoscale, 7 (28), 11894-11898. doi: 10.1039/c5nr02769a
Yuan, Pei, Yang, Jie, Zhang, Hongwei, Song, Hao, Huang, Xiaodan, Bao, Xiaojun, Zou, Jin and Yu, Chengzhong (2015). New insight into ordered cage-type mesostructures and their pore size determination by electron tomography. Langmuir, 31 (8), 2545-2553. doi: 10.1021/la504474z
Li, Jiansheng, Qi, Junwen, Liu, Chao, Zhou, Liang, Song, Hao, Yu, Chengzhong, Shen, Jinyou, Sun, Xiuyun and Wang, Lianjun (2014). Fabrication of ordered mesoporous carbon hollow fiber membranes via a confined soft templating approach. Journal of Materials Chemistry A, 2 (12), 4144-4149. doi: 10.1039/c3ta14884j
Liu, Zhen, Du, Zhenyu, Song, Hao, Wang, Chuangye, Subhan, Fazle, Xing, Wei and Yan, Zifeng (2014). The fabrication of porous N-doped carbon from widely available urea formaldehyde resin for carbon dioxide adsorption. Journal of Colloid and Interface Science, 416, 124-132. doi: 10.1016/j.jcis.2013.10.061
Preparation of porous core shell copper zinc oxide nanospheres for lysozyme delivery
Nor, Yusilawati Ahmad, Johari, Farahanim, Meka, Anand Kumar, Song, Hao, Jimat, Dzun Noraini and Jamal, Nur Ayuni (2021). Preparation of porous core shell copper zinc oxide nanospheres for lysozyme delivery. -, -, -. Geneva, Switzerland: Inderscience Publishers. doi: 10.1504/IJNP.2021.118107
Engineered silica nanoparticles for efficient biomolecules delivery
Song, Hao (2018). Engineered silica nanoparticles for efficient biomolecules delivery. PhD Thesis, Aust Institute for Bioengineering & Nanotechnology, The University of Queensland. doi: 10.14264/uql.2018.130
Bio-inspired Nanoparticles for Next-generation Shelf-stable mRNA Vaccines
(2023) UQ Foundation Research Excellence Awards
A Long-Lasting Oral Drug Delivery System Using Spiky Silica Nanoparticles
(2021–2025) NHMRC Investigator Grants
Development of a market relevant DNA nano-vaccine platform
(2021–2025) ARC Linkage Projects
Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces
(2021–2024) ARC Discovery Early Career Researcher Award
Developing a thermal-stable nanoparticle-based oral vaccine: towards commercial reality
(2021–2022) UQ Knowledge Exchange & Translation Fund
COVID-19 DNA vaccine in vivo study using NUVEC nanoparticles
(2020–2021) UniQuest Pty Ltd
N4 Pharma - repeat and extension of in vivo DNA vaccine study
(2019–2021) UniQuest Pty Ltd
PEI Modification of CPI-NPs - compare PEI suppliers
(2019–2020) UniQuest Pty Ltd
Multi-Scale Engineered Nano-Adjuvants for DNA Vaccine
(2019) UQ Early Career Researcher
To attend 2018 MRS Fall Meeting and Exhibit, Boston, USA, 23 November 2018 - 01 December 2018
(2018) Ian Potter Foundation
clinically-oriented synergized immunotherapy strategies for breast cancer
Doctor Philosophy — Principal Advisor
Biomimetic Nanoparticles for Efficient Vaccine Delivery
Doctor Philosophy — Principal Advisor
Engineering Spiky Nanoparticles Probed at the Nano-Bio Interfaces
Doctor Philosophy — Principal Advisor
Other advisors:
Synthesis and applications of non-viral gene vectors
Doctor Philosophy — Associate Advisor
Other advisors:
Development of a market relevant DNA nano-vaccine platform
Doctor Philosophy — Associate Advisor
Other advisors:
Development of Nano-Biopesticides for Animal Healthcare
Doctor Philosophy — Associate Advisor
Other advisors:
Engineering encapsulation technology for animal feed manufacture
Doctor Philosophy — Associate Advisor
(2023) Doctor Philosophy — Associate Advisor
Other advisors:
Nanoparticle-Assisted Signal-Enhancement Technique for Lateral Flow Immunoassays
(2022) Doctor Philosophy — Associate Advisor
Other advisors:
Engineered Aluminosilicate-Based Nanoparticles for Safe and Efficient Vaccine Delivery
(2021) Doctor Philosophy — Associate Advisor
Other advisors:
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
A nanotechnology for long-lasting oral drug delivery.
Medication adherence is required for the effectiveness of all pharmacotherapies, especially for long-term treatment of chronic illness and infectious diseases such as malaria, diabetes, and HIV. However, intensive dosage regimens with a high pill burden are associated with a low adherence rate, leading to compromised or even failure of therapies. My project aims to realize the ideal of ‘pillbox in a capsule’, i.e. taking a single tablet that will provide sustained drug release over several days, by developing a long-lasting oral drug delivery platform with prolonged gastrointestinal transit time. Inspired by bio-adhesive natural systems, where spiky surfaces enable strong adhesion, this project will engineer silica particles with a spiky morphology as well as their assembled medical devices as oral drug delivery vehicles, and their interactions at the bio-interfaces in the gastrointestinal environment will be investigated in detail. On completion, this project will produce guidelines for the rational design of novel oral drug delivery systems, and new potential clinical strategies for simplified oral medications to improve medication adherence and patient outcomes.
Virus-mimicking nanoparticles for DNA vaccine
DNA vaccine, as the third generation vaccine technology, representing the latest biotechnological breakthrough in vaccine development. Compared to conventional recombinant vaccines usually only stimulating the antibody responses, DNA vaccine show advantages in evoking both cellular and humoral immunity to fulfill the demand in combating chronic infectious diseases. Moreover, the cost-effectiveness and fast speed of production make DNA vaccine an ideal strategy to deal with outbreaks such as SARS-COV-2 and H5N1 for the sake of both public and animal healthcare. To enable a successful DNA vaccine technology, it is critical to develop efficient gene vectors to transport and regulate the DNA molecules to be highly expressed in target cells. Mimicking the morphology of the virus, this project aims to fabricate a series of virus-like silica nanoparticles with tailored physicochemical features for plasmid DNA delivery and investigate their gene translation and vaccine performance. The completion of this project will provide fundamental understandings of the impact of designer particle nanostructure/chemistry on DNA transfection and vaccine immunogenicity.
Nature-inspired spiky nanomaterials probed at the bio-nano interfaces
The intriguing nature systems have inspired remarkable advances in the development of functional nanomaterials for biomedical applications. Nature creations such as pollen grains and virus with spiky topological features at various length scales enable multivalent interactions at bio-interfaces, and typically exhibit intriguing surface adhesive property. This project aims to apply this nature-derived principle to engineer nanoparticles for enhanced intracellular delivery of biomolecules. Nanomaterials with functional compositions and tailored spiky nanostructures will be fabricated. Their cellular internalization process and biomolecules delivery efficiency will be evaluated. On completion of this project, a versatile and functional drug delivery platform will be established and an in-depth understanding of the spiky nanoparticle-cell interaction will be revealed.
Antibiotic-free antibacterial nanotechnology
The overuse of antibiotics leads to ever-increasing antibiotic resistance, posing a severe threat to human health. Recent advances in nanotechnology provide new opportunities to address the challenges in bacterial infection by killing germs without using antibiotics. This project aims to develop antibiotic-free antibacterial formulations enabled by advanced nanomaterials. Functional nanomaterials with intrinsic or light-mediated bactericidal properties will be fabricated to enable efficient pathogen killing. Meanwhile, porous nanoparticles will also be engineered to serve as vehicles for the delivery of natural antibacterial compounds, formulating Pickering emulsion for stable and sparable antibacterial nano-agents. On the completion of this project, nano-formulations showing potent antibacterial property and good safety will be provided, and their antibacterial mechanisms, as well as the structure-performance relationship, will be revealed.