Dr Wuethrich is an NHMRC Emerging Leader fellow and ARC DECRA awardee at the Centre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland (UQ). Dr Wuethrich obtained his PhD from the University of Tasmania in 2016 after completing a Master’s degree in Switzerland. His research expertise lies in liquid biopsy, electrohydrodynamics, surface-enhanced Raman spectroscopy, nanotechnology and diagnostics. He held positions in international pharmaceutical companies and became lead inventor on a European patent. He has actively engaged with national and international companies to translate diagnostic nanotechnologies. Since 2017 he has provided continuous research mentoring to the group and has supervised >30 postgraduate and graduate students in nanotechnological strategies to detect cancer and other diseases.
Yuan, Liwen, Chen, Yanpin, Ke, Longfeng, Zhou, Quan, Chen, Jiayou, Fan, Min, Wuethrich, Alain, Trau, Matt and Wang, Jing (2023). Erratum: Correction: Plasma extracellular vesicle phenotyping for the differentiation of early-stage lung cancer and benign lung diseases (Nanoscale horizons (2023) 8 6 (746-758)). Nanoscale horizons, 8 (9), 1288-1289. doi: 10.1039/d3nh90028b
Journal Article: A microfluidic liquid biopsy platform to monitor protein biomarker heterogeneity in single circulating therapy‐resistance cancer cell
Ahmed, Emtiaz, Shanmugasundaram, Karthik Balaji, Li, Junrong, Behren, Andreas, Lobb, Richard, Möller, Andreas, Wuethrich, Alain, Dey, Shuvashis, Sina, Abu Ali Ibn and Trau, Matt (2023). A microfluidic liquid biopsy platform to monitor protein biomarker heterogeneity in single circulating therapy‐resistance cancer cell. Advanced Sensor Research. doi: 10.1002/adsr.202300059
Journal Article: A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments
Li, Junrong, Howard, Christopher B., Dey, Shuvashis, Lowry, Kym, Whiley, David M., Puttick, Simon, Rose, Stephen, Lobb, Richard J., Wuethrich, Alain, Edwardraja, Selvakumar and Trau, Matt (2023). A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments. Nature Nanotechnology. doi: 10.1038/s41565-023-01415-1
(2023–2027) University of Sydney
nanoIMPAC: Monitoring immune toxicities and tumour immune evasion in lung cancer
(2022–2025) Cancer Australia
Single molecule sensing on nanopillars: Reading complex molecular circuits
(2021–2023) ARC Discovery Projects
Harnessing nanotechnology to unravel the phenotypic heterogeneity of extracellular vesicles
Doctor Philosophy
A protein phosphorylation mapping tool for monitoring tyrosine kinase inhibition therapy in cancer patients
Doctor Philosophy
Clinical Epigenetics: Biomarkers for Human Health and Diseases
Doctor Philosophy
Wang, Jing, Trau, Matt and Wuethrich, Alain (2023). A Microfluidic SERS Assay to Characterize the Phenotypic Heterogeneity in Cancer-Derived Small Extracellular Vesicles. Microfluidic Systems for Cancer Diagnosis. (pp. 241-253) New York, NY: Springer US. doi: 10.1007/978-1-0716-3271-0_17
Wuethrich, Alain, Dey, Shuvashis, Koo, Kevin M, Sina, Abu A. I. and Trau, Matt (2021). Simultaneous BRAFV600E protein and DNA aberration detection in circulating melanoma cells using an integrated multimolecular sensor. Melanoma. (pp. 265-276) New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1205-7_20
Derivatization of carbohydrates for analysis by liquid chromatography and capillary electrophoresis
Yu, Raymond B., Dalman, Neil A. V., Wuethrich, Alain and Quirino, Joselito P. (2021). Derivatization of carbohydrates for analysis by liquid chromatography and capillary electrophoresis. Carbohydrate Analysis by Modern Liquid Phase Separation Techniques. (pp. 1-33) edited by Ziad El Rassi. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-821447-3.00019-6
Capillary electrophoresis: overview
Quirino, Joselito P. and Wuethrich, Alain (2018). Capillary electrophoresis: overview. Reference module in chemistry, molecular sciences and chemical engineering. (pp. 1-32) edited by Jan Reedijk. Oxford, United Kingdom: Elsevier. doi: 10.1016/b978-0-12-409547-2.14461-0
Stacking or On-line Sample Concentration in CE-MS for Metabolomics
Wuethrich, Alain and Quirino, Joselito P. (2018). Stacking or On-line Sample Concentration in CE-MS for Metabolomics. Capillary electrophoresis–mass spectrometry for metabolomics. (pp. 83-112) Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781788012737-00083
Capillary Electrophoresis as a Green Alternative Separation Technique
Wuethrich, Alain and Quirino, Joselito P. (2017). Capillary Electrophoresis as a Green Alternative Separation Technique. The Application of Green Solvents in Separation Processes. (pp. 517-532) Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-805297-6.00017-6
Yuan, Liwen, Chen, Yanpin, Ke, Longfeng, Zhou, Quan, Chen, Jiayou, Fan, Min, Wuethrich, Alain, Trau, Matt and Wang, Jing (2023). Erratum: Correction: Plasma extracellular vesicle phenotyping for the differentiation of early-stage lung cancer and benign lung diseases (Nanoscale horizons (2023) 8 6 (746-758)). Nanoscale horizons, 8 (9), 1288-1289. doi: 10.1039/d3nh90028b
Ahmed, Emtiaz, Shanmugasundaram, Karthik Balaji, Li, Junrong, Behren, Andreas, Lobb, Richard, Möller, Andreas, Wuethrich, Alain, Dey, Shuvashis, Sina, Abu Ali Ibn and Trau, Matt (2023). A microfluidic liquid biopsy platform to monitor protein biomarker heterogeneity in single circulating therapy‐resistance cancer cell. Advanced Sensor Research. doi: 10.1002/adsr.202300059
Li, Junrong, Howard, Christopher B., Dey, Shuvashis, Lowry, Kym, Whiley, David M., Puttick, Simon, Rose, Stephen, Lobb, Richard J., Wuethrich, Alain, Edwardraja, Selvakumar and Trau, Matt (2023). A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments. Nature Nanotechnology. doi: 10.1038/s41565-023-01415-1
Yuan, Liwen, Chen, Yanping, Ke, Longfeng, Zhou, Quan, Chen, Jiayou, Fan, Min, Wuethrich, Alain, Trau, Matt and Wang, Jing (2023). Plasma extracellular vesicle phenotyping for the differentiation of early-stage lung cancer and benign lung disease. Nanoscale Horizons, 8 (6), 746-758. doi: 10.1039/d2nh00570k
Ahmed, Mostak, Wuethrich, Alain, Constantin, Nicolas, Shanmugasundaram, Karthik Balaji, Mainwaring, Paul, Kulasinghe, Arutha, O’Leary, Connor, O’Byrne, Ken, Sina, Abu Ali Ibn, Carrascosa, Laura G. and Trau, Matt (2023). Liquid Biopsy Snapshots of Key Phosphoproteomic Pathways in Lung Cancer Patients for Diagnosis and Therapy Monitoring. Analytical Chemistry, 95 (22), 8522-8532. doi: 10.1021/acs.analchem.3c00519
A multiplexed SERS microassay for accurate detection of SARS-CoV-2 and variants of concern
Vedelago, Courtney, Li, Junrong, Lowry, Kym, Howard, Christopher, Wuethrich, Alain and Trau, Matt (2023). A multiplexed SERS microassay for accurate detection of SARS-CoV-2 and variants of concern. ACS Sensors, 8 (4), 1648-1657. doi: 10.1021/acssensors.2c02782
Liao, Caizhi, Wu, Zhihao, Lin, Chan, Chen, Xiaofeng, Zou, Yaqun, Zhao, Wan, Li, Xin, Huang, Guangqi, Xu, Baisheng, Briganti, Giovanni E., Qi, Yan, Wang, Xianshu, Zeng, Tao, Wuethrich, Alain and Zou, Hongzhi (2023). Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer. Smart Medicine, 2 (1). doi: 10.1002/smmd.20220020
Li, Junrong, Sina, Abu A. I., Antaw, Fiach, Fielding, David, Möller, Andreas, Lobb, Richard, Wuethrich, Alain and Trau, Matt (2023). Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions. Advanced Science, 10 (1) 2204207. doi: 10.1002/advs.202204207
Status quo of extracellular vesicle isolation and detection methods for clinical utility
Visan, Kekoolani S., Wu, Li-Ying, Voss, Sarah, Wuethrich, Alain and Möller, Andreas (2023). Status quo of extracellular vesicle isolation and detection methods for clinical utility. Seminars in Cancer Biology, 88, 157-171. doi: 10.1016/j.semcancer.2022.12.008
Li, Junrong, Wuethrich, Alain, Zhang, Zhen, Wang, Jing, Lin, Lynlee L., Behren, Andreas, Wang, Yuling and Trau, Matt (2022). SERS multiplex profiling of melanoma circulating tumor cells for predicting the response to immune checkpoint blockade therapy. Analytical Chemistry, 94 (42), 14573-14582. doi: 10.1021/acs.analchem.2c02398
Farokhinejad, Fahimeh, Li, Junrong, Hugo, Leon E., Howard, Christopher B., Wuethrich, Alain and Trau, Matt (2022). Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes. Analytical Chemistry, 94 (41), 14177-14184. doi: 10.1021/acs.analchem.2c02012
A T‐junction dual nanopore for single nanoparticle analysis
Liao, Caizhi, Antaw, Fiach, Wuethrich, Alain and Trau, Matt (2022). A T‐junction dual nanopore for single nanoparticle analysis. Advanced Engineering Materials, 24 (4) 2101015, 2101015. doi: 10.1002/adem.202101015
Kolka, Cathryn M., Webster, Julie, Lepletier, Ailin, Winterford, Clay, Brown, Ian, Richards, Renee S., Zelek, Wioleta M., Cao, Yilang, Khamis, Ramlah, Shanmugasundaram, Karthik B., Wuethrich, Alain, Trau, Matt, Brosda, Sandra, Barbour, Andrew, Shah, Alok K., Eslick, Guy D., Clemons, Nicholas J., Morgan, B. Paul and Hill, Michelle M. (2022). C5b-9 membrane attack complex formation and extracellular vesicle shedding in Barrett’s esophagus and esophageal adenocarcinoma. Frontiers in Immunology, 13 842023, 842023. doi: 10.3389/fimmu.2022.842023
Dey, Shuvashis, Ahmed, Emtiaz, Somvanshi, Pranjal Satishchandra, Sina, Abu Ali Ibn, Wuethrich, Alain and Trau, Matt (2022). An electrochemical and raman scattering dual detection biosensor for rapid screening and biomolecular profiling of cancer biomarkers. Chemosensors, 10 (3) 93. doi: 10.3390/chemosensors10030093
Shanmugasundaram, Karthik Balaji, Li, Junrong, Sina, Abu Ibn, Wuethrich, Alain and Trau, Matt (2022). Toward precision oncology: SERS microfluidic systems for multiplex biomarker analysis in liquid biopsy. Materials Advances, 3 (3), 1459-1471. doi: 10.1039/d1ma00848j
Dynamic monitoring of EMT in CTCs as an indicator of cancer metastasis
Zhang, Zhen, Wuethrich, Alain, Wang, Jing, Korbie, Darren, Lin, Lynlee L. and Trau, Matt (2021). Dynamic monitoring of EMT in CTCs as an indicator of cancer metastasis. Analytical Chemistry, 93 (50) acs.analchem.1c03167, 16787-16795. doi: 10.1021/acs.analchem.1c03167
Farokhinejad, Fahimeh, Lane, Rebecca E., Lobb, Richard J., Edwardraja, Selvakumar, Wuethrich, Alain, Howard, Christopher B. and Trau, Matt (2021). Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection. ACS Biomaterials Science and Engineering, 7 (12) acsbiomaterials.1c01001, 5850-5860. doi: 10.1021/acsbiomaterials.1c01001
Ahmed, Mohamed Adel, Felisilda, Bren Mark, Wuethrich, Alain and Quirino, Joselito P. (2021). A stationary pseudophase semi-permanent coating for open-tubular capillary liquid chromatography and electrochromatography. Journal of Chromatography A, 1657 462553, 462553. doi: 10.1016/j.chroma.2021.462553
Wang, Jing, Kao, Yung‐Ching, Zhou, Quan, Wuethrich, Alain, Stark, Mitchell S., Schaider, Helmut, Soyer, H. Peter, Lin, Lynlee L. and Trau, Matt (2021). An integrated microfluidic‐SERS platform enables sensitive phenotyping of serum extracellular vesicles in early stage melanomas. Advanced Functional Materials, 32 (3) 2010296, 1-9. doi: 10.1002/adfm.202010296
Li, Junrong, Wuethrich, Alain, Edwardraja, Selvakumar, Lobb, Richard J., Puttick, Simon, Rose, Stephen, Howard, Christopher B. and Trau, Matt (2021). Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay. Analytical Chemistry, 93 (29) acs.analchem.1c01657, 10251-10260. doi: 10.1021/acs.analchem.1c01657
Wang, Jing, Wuethrich, Alain, Lobb, Richard J., Antaw, Fiach, Sina, Abu Ali Ibn, Lane, Rebecca E., Zhou, Quan, Zieschank, Chloe, Bell, Caroline, Bonazzi, Vanessa F., Aoude, Lauren G., Everitt, Sarah, Yeo, Belinda, Barbour, Andrew P., Möller, Andreas and Trau, Matt (2021). Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip. ACS Sensors, 6 (9) acssensors.1c00358, 3182-3194. doi: 10.1021/acssensors.1c00358
In situ single cell proteomics reveals circulating tumor cell heterogeneity during treatment
Reza, K. Kamil, Dey, Shuvashis, Wuethrich, Alain, Wang, Jing, Behren, Andreas, Antaw, Fiach, Wang, Yuling, Sina, Abu Ali Ibn and Trau, Matt (2021). In situ single cell proteomics reveals circulating tumor cell heterogeneity during treatment. ACS Nano, 15 (7) acsnano.0c10008, 11231-11243. doi: 10.1021/acsnano.0c10008
Webster, Julie A., Wuethrich, Alain, Shanmugasundaram, Karthik B., Richards, Renee S., Zelek, Wioleta M., Shah, Alok K., Gordon, Louisa G., Kendall, Bradley J., Hartel, Gunter, Morgan, B. Paul, Trau, Matt and Hill, Michelle M. (2021). Development of EndoScreen chip, a microfluidic pre-endoscopy triage test for esophageal adenocarcinoma. Cancers, 13 (12) 2865, 2865. doi: 10.3390/cancers13122865
On the behavior of nanoparticles beyond the nanopore interface
Antaw, Fiach, Anderson, Will, Wuethrich, Alain and Trau, Matt (2021). On the behavior of nanoparticles beyond the nanopore interface. Langmuir, 37 (16), 4772-4782. doi: 10.1021/acs.langmuir.0c03083
Li, Junrong, Wuethrich, Alain, Sina, Abu A. I., Cheng, Han-Hao, Wang, Yuling, Behren, Andreas, Mainwaring, Paul N. and Trau, Matt (2021). A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy. Nature Communications, 12 (1) 1087, 1-12. doi: 10.1038/s41467-021-21431-w
Stacked dual‐pore architecture for deciphering and manipulating dynamics of individual nanoparticles
Liao, Caizhi, Antaw, Fiach, Wuethrich, Alain and Trau, Matt (2020). Stacked dual‐pore architecture for deciphering and manipulating dynamics of individual nanoparticles. Advanced Materials Technologies, 5 (11) 2000701, 2000701. doi: 10.1002/admt.202000701
Configurable miniaturized 3D pores for robust single‐nanoparticle analysis
Liao, Caizhi, Antaw, Fiach, Wuethrich, Alain, Anderson, Will and Trau, Matt (2020). Configurable miniaturized 3D pores for robust single‐nanoparticle analysis. Small Structures, 1 (2). doi: 10.1002/sstr.202000011
Li, Junrong, Wuethrich, Alain, Dey, Shuvashi, Lane, Rebecca E., Sina, Abu A. I., Wang, Jing, Wang, Yuling, Puttick, Simon, Koo, Kevin M. and Trau, Matt (2020). Multiomics: The Growing Impact of Micro/Nanomaterial‐Based Systems in Precision Oncology: Translating “Multiomics” Technologies (Adv. Funct. Mater. 37/2020). Advanced Functional Materials, 30 (37) 2070248. doi: 10.1002/adfm.202070248
Sina, Abu Ali Ibn, Lin, Ting-Yun, Vaidyanathan, Ramanathan, Wang, Zhaoran, Dey, Shuvashis, Wang, Jing, Behren, Andreas, Wuethrich, Alain, Carrascosa, Laura G. and Trau, Matt (2020). Methylation dependent gold adsorption behaviour identifies cancer derived extracellular vesicular DNA. Nanoscale Horizons, 5 (9), 1317-1323. doi: 10.1039/d0nh00258e
Liao, Caizhi, Wuethrich, Alain and Trau, Matt (2020). A material odyssey for 3D nano/microstructures: two photon polymerization based nanolithography in bioapplications. Applied Materials Today, 19 100635, 100635. doi: 10.1016/j.apmt.2020.100635
Zhang, Zhen, Wang, Jing, Shanmugasundaram, Karthik Balaji, Yeo, Belinda, Möller, Andreas, Wuethrich, Alain, Lin, Lynlee L. and Trau, Matt (2020). Tracking drug-induced epithelial–mesenchymal transition in breast cancer by a microfluidic surface-enhanced raman spectroscopy immunoassay. Small, 16 (13) 1905614, e1905614. doi: 10.1002/smll.201905614
Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma
Wang, Jing, Wuethrich, Alain, Sina, Abu Ali Ibn, Lane, Rebecca E., Lin, Lynlee L., Wang, Yuling, Cebon, Jonathan, Behren, Andreas and Trau, Matt (2020). Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma. Science Advances, 6 (9) eaax3223, eaax3223. doi: 10.1126/sciadv.aax3223
Li, Junrong, Wuethrich, Alain, Dey, Shuvashi, Lane, Rebecca E., Sina, Abu A. I., Wang, Jing, Wang, Yuling, Puttick, Simon, Koo, Kevin M. and Trau, Matt (2020). The growing impact of micro/nanomaterial-based systems in precision oncology: translating “multiomics” technologies. Advanced Functional Materials, 30 (37) 1909306, 1909306. doi: 10.1002/adfm.201909306
Kumar, Aswin Raj, Shanmugasundaram, Karthik Balaji, Li, Junrong, Zhang, Zhen, Ibn Sina, Abu Ali, Wuethrich, Alain and Trau, Matt (2020). Ultrasensitive melanoma biomarker detection using a microchip SERS immunoassay with anisotropic Au–Ag alloy nanoboxes. RSC Advances, 10 (48), 28778-28785. doi: 10.1039/d0ra05032f
Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor
Wuethrich, Alain, Rajkumar, Aswin Raj, Shanmugasundaram, Karthik Balaji, Reza, Kamil K., Dey, Shuvashis, Howard, Christopher B., Sina, Abu Ali Ibn and Trau, Matt (2019). Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor. The Analyst, 144 (23), 6914-6921. doi: 10.1039/c9an01450k
Khondakar, Kamil Reza, Dey, Shuvashis, Wuethrich, Alain, Sina, Abu Ali Ibn and Trau, Matt (2019). Toward personalized cancer treatment: from diagnostics to therapy monitoring in miniaturized electrohydrodynamic systems. Accounts of Chemical Research, 52 (8) acs.accounts.9b00192, 2113-2123. doi: 10.1021/acs.accounts.9b00192
Label-free detection of exosomes using surface plasmon resonance biosensor
Sina, A.A.I., Vaidyanathan, R., Wuethrich, A., Carrascosa, L. G. and Trau, M. (2019). Label-free detection of exosomes using surface plasmon resonance biosensor. Analytical and Bioanalytical Chemistry, 411 (7), 1311-1318. doi: 10.1007/s00216-019-01608-5
Breadmore, Michael C., Grochocki, Wojciech, Kalsoom, Umme, Alves, Mónica N., Phung, Sui Ching, Rokh, Masoomeh Tehrani, Cabot, Joan M., Ghiasvand, Alireza, Li, Feng, Shallan, Aliaa I., Keyon, Aemi S. Abdul, Alhusban, Ala A., See, Hong Heng, Wuethrich, Alain, Dawod, Mohamed and Quirino, Joselito P. (2019). Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2016–2018). Electrophoresis, 40 (1), 17-39. doi: 10.1002/elps.201800384
Tracking antigen specific T-cells: technological advancement and limitations
Dey, Shuvashis, Kamil Reza, K., Wuethrich, Alain, Korbie, Darren, Ibn Sina, Abu Ali and Trau, Matt (2019). Tracking antigen specific T-cells: technological advancement and limitations. Biotechnology Advances, 37 (1), 145-153. doi: 10.1016/j.biotechadv.2018.11.010
Dey, Shuvashis, Koo, Kevin, Wang, Zhaoran, Sina, Abu Ali Ibn, Wuethrich, Alain and Trau, Matt (2018). An integrated multi-molecular sensor for simultaneous BRAFV600E protein and DNA single point mutation detection in circulating tumour cells. Lab on a Chip, 19 (5), 738-748. doi: 10.1039/c8lc00991k
A SERS microfluidic platform for targeting multiple soluble immune checkpoints
Reza, K. Kamil, Sina, Abu Ali Ibn, Wuethrich, Alain, Grewal, Yadveer S., Howard, Christopher B., Korbie, Darren and Trau, Matt (2018). A SERS microfluidic platform for targeting multiple soluble immune checkpoints. Biosensors and Bioelectronics, 126, 178-186. doi: 10.1016/j.bios.2018.10.044
Reza, K. Kamil, Dey, Shuvashis, Wuethrich, Alain, Sina, Abu Ali Ibn, Korbie, Darren, Wang, Yuling and Trau, Matt (2018). Parallel profiling of cancer cells and proteins using a graphene oxide functionalized ac-EHD SERS immunoassay. Nanoscale, 10 (39), 18482-18491. doi: 10.1039/c8nr02886a
A decade of microchip electrophoresis for clinical diagnostics – a review of 2008-2017
Wuethrich, Alain and Quirino, Joselito P. (2018). A decade of microchip electrophoresis for clinical diagnostics – a review of 2008-2017. Analytica Chimica Acta, 1045, 42-66. doi: 10.1016/j.aca.2018.08.009
Ahmed, Mostak, Carrascosa, Laura G, Wuethrich, Alain, Mainwaring, Paul and Trau, Matt (2018). An exosomal- and interfacial-biosensing based strategy for remote monitoring of aberrantly phosphorylated proteins in lung cancer cells. Biomaterials Science, 6 (9), 2336-2341. doi: 10.1039/c8bm00629f
Wuethrich, Alain, Sina, Abu Ali Ibn, Ahmed, Mostak, Lin, Ting-Yun, Carrascosa, Laura G. and Trau, Matt (2018). Interfacial nano-mixing in a miniaturised platform enables signal enhancement and in situ detection of cancer biomarkers. Nanoscale, 10 (23), 10884-10890. doi: 10.1039/C7NR09496E
Derivatisation for separation and detection in capillary electrophoresis (2015–2017)
Wuethrich, Alain and Quirino, Joselito P. (2018). Derivatisation for separation and detection in capillary electrophoresis (2015–2017). Electrophoresis, 39 (1), 82-96. doi: 10.1002/elps.201700252
Geometric optimisation of electrohydrodynamic fluid flows for enhanced biosensing
Wuethrich, Alain, Howard, Christopher B. and Trau, Matt (2017). Geometric optimisation of electrohydrodynamic fluid flows for enhanced biosensing. Microchemical Journal, 137, 231-237. doi: 10.1016/j.microc.2017.10.012
Electrophoretic concentration - a simple and green approach for sample preparation
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2017). Electrophoretic concentration - a simple and green approach for sample preparation. LCGC North America: solution for separation scientists, 35 (3), 197-201.
Wuethrich, Alain and Quirino, Joselito P. (2017). Sensitivity enhancing injection from a sample reservoir and channel interface in microchip electrophoresis. Journal of Separation Science, 40 (4), 927-932. doi: 10.1002/jssc.201601064
Electrophoretic concentration — a simple and green approach for sample preparation
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2017). Electrophoretic concentration — a simple and green approach for sample preparation. LC-GC Europe, 30 (2), 60-67.
Breadmore, Michael C., Grochocki, Wojciech, Kalsoom, Umme, Alves, Mónica N., Phung, Sui Ching, Rokh, Masoomeh Tehrani, Cabot, Joan M., Ghiasvand, Alireza, Li, Feng, Shallan, Aliaa I., Keyon, Aemi S. Abdul, Alhusban, Ala A., See, Hong Heng, Wuethrich, Alain, Dawod, Mohamed and Quirino, Joselito P. (2017). Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2014–2016). Electrophoresis, 38 (1), 33-59. doi: 10.1002/elps.201600331
Wuethrich, Alain and Quirino, Joselito P. (2016). Unusual stacking with electrokinetic injection of cationic analytes from micellar solutions in capillary zone electrophoresis. Analytical and Bioanalytical Chemistry, 408 (30), 8663-8668. doi: 10.1007/s00216-016-9735-1
The electric field - an emerging driver in sample preparation
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2016). The electric field - an emerging driver in sample preparation. TrAC - Trends in Analytical Chemistry, 80, 604-611. doi: 10.1016/j.trac.2016.04.016
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2016). Simultaneous electrophoretic concentration and separation of herbicides in beer prior to stacking capillary electrophoresis UV and liquid chromatography-mass spectrometry. Electrophoresis, 37 (9), 1122-1128. doi: 10.1002/elps.201600050
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2016). Field-enhanced sample injection micelle-to-solvent stacking capillary zone electrophoresis-electrospray ionization mass spectrometry of antibiotics in seawater after solid-phase extraction: CE and CEC. Electrophoresis, 37 (9), 1139-1142. doi: 10.1002/elps.201500448
Electrokinetic properties of lubricin antiadhesive coatings in microfluidic systems
Greene, George W., Duffy, Emer, Shallan, Aliaa, Wuethrich, Alain and Paull, Brett (2016). Electrokinetic properties of lubricin antiadhesive coatings in microfluidic systems. Langmuir, 32 (7), 1899-1908. doi: 10.1021/acs.langmuir.5b03535
Derivatisation for separation and detection in capillary electrophoresis (2012-2015)
Wuethrich, Alain and Quirino, Joselito P. (2016). Derivatisation for separation and detection in capillary electrophoresis (2012-2015). Electrophoresis, 37 (1), 45-55. doi: 10.1002/elps.201500290
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2015). Electrophoretic concentration and sweeping-micellar electrokinetic chromatography analysis of cationic drugs in water samples. Journal of Chromatography A, 1401, 84-88. doi: 10.1016/j.chroma.2015.05.018
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2015). Green sample preparation for liquid chromatography and capillary electrophoresis of anionic and cationic analytes. Analytical Chemistry, 87 (8), 4117-4123. doi: 10.1021/ac504765h
Off-line sample preparation by electrophoretic concentration using a micropipette and hydrogel
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2014). Off-line sample preparation by electrophoretic concentration using a micropipette and hydrogel. Journal of Chromatography A, 1369, 186-190. doi: 10.1016/j.chroma.2014.10.006
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2014). Online sample concentration in partial-filling chiral electrokinetic chromatography - mass spectrometry. Chirality, 26 (11), 734-738. doi: 10.1002/chir.22257
Zero net-flow in capillary electrophoresis using acrylamide based hydrogel
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2014). Zero net-flow in capillary electrophoresis using acrylamide based hydrogel. Analyst, 139 (15), 3722-3726. doi: 10.1039/c4an00557k
Chiral capillary electromigration techniques-mass spectrometry-hope and promise
Wuethrich, Alain, Haddad, Paul R. and Quirino, Joselito P. (2014). Chiral capillary electromigration techniques-mass spectrometry-hope and promise. Electrophoresis, 35 (1), 2-11. doi: 10.1002/elps.201300377
3D printed chitosan / hydroxyapatite scaffolds for potential use in regenerative medicine
Chavanne, Philippe, Stevanovic, Sabrina, Wüthrich, Alain, Braissant, Olivier, Pieles, Uwe, Gruner, Philipp and Schumacher, Ralf (2013). 3D printed chitosan / hydroxyapatite scaffolds for potential use in regenerative medicine. BMT (Biomedizinische Technik) 2013, Graz, Austria, 2013. Berlin, Germany: Walter de Gruyter. doi: 10.1515/bmt-2013-4069
(2023–2027) University of Sydney
nanoIMPAC: Monitoring immune toxicities and tumour immune evasion in lung cancer
(2022–2025) Cancer Australia
Single molecule sensing on nanopillars: Reading complex molecular circuits
(2021–2023) ARC Discovery Projects
(2020–2024) NHMRC Investigator Grants
Harnessing nanotechnology to unravel extracellular vesicle heterogeneity
(2020) ARC Discovery Early Career Researcher Award
(2019) UQ Early Career Researcher
Enhanced electrochemical biosensing through electrohydrodynamic nanofluidics for cancer diagnostics
(2018–2019) UQ Development Fellowships
Harnessing nanotechnology to unravel the phenotypic heterogeneity of extracellular vesicles
Doctor Philosophy — Principal Advisor
Other advisors:
A protein phosphorylation mapping tool for monitoring tyrosine kinase inhibition therapy in cancer patients
Doctor Philosophy — Principal Advisor
Other advisors:
Clinical Epigenetics: Biomarkers for Human Health and Diseases
Doctor Philosophy — Associate Advisor
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The investigation of microglial activation in brain cancer and brain metastasis by an integrated nano-sensor
Doctor Philosophy — Associate Advisor
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Single molecule sensing on nanopillars: Reading complex molecular circuits
Doctor Philosophy — Associate Advisor
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A nano-engineered chip to help manage acute and long-haul COVID-19 patients
Doctor Philosophy — Associate Advisor
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Utilising extracellular vesicles for the diagnosis of lung cancer.
Doctor Philosophy — Associate Advisor
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Bioengineering yeast nanofragment affinity probes for dengue diagnostics
(2023) Doctor Philosophy — Associate Advisor
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(2023) Doctor Philosophy — Associate Advisor
Other advisors:
(2021) Doctor Philosophy — Associate Advisor
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