Research Fellow
Overview
David M. Klyne PhD, MSc (MolBiol), DPhty, BAppSc is a Research Fellow within the Centre for Clinical Research Excellence in Spinal Pain, Injury and Health. David’s research focuses on understanding the physiology of pain and the complex mechanisms that drive its persistence. His unique approach, from fundamental mechanisms to whole animal and human research, has helped reveal the inner-workings of pain, and how it can be optimally targeted with interventions.
David has received numerous national and international research awards that span basic and clinical sciences. These include the premier international award for spine research (ISSLS Prize) on two occasions – in Basic Science (2019) and Clinical Science (2018). In 2019, he was awarded a postdoctoral Fulbright Fellowship to continue his work elucidating the role of sleep in chronic pain at the Lewis Katz School of Medicine (Temple University), in the USA. He was also selected by the Australian Academy of Science and Lindau Council to represent Australia at the prestigious Nobel Laureate Meeting in Germany, 2020.
Research Interests
- Acute to chronic pain
- Neuro-immunology
- Sleep
- Chronic pain prevention and rehabilitation
Qualifications
- Doctor of Philosophy, The University of Queensland
- Master of Molecular Biology, The University of Queensland
- Doctor of Physiotherapy, Bond University
- Bachelor of Applied Science, Queenland University of Technology
Publications
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Hall, Michelle, Allison, Kim, Hinman, Rana S., Bennell, Kim L., Spiers, Libby, Knox, Gabrielle, Plinsinga, Melanie, Klyne, David M., McManus, Fiona, Lamb, Karen E., Da Costa, Ricardo, Murphy, Nicholas J. and Dobson, Fiona L. (2022). Effects of adding aerobic physical activity to strengthening exercise on hip osteoarthritis symptoms: protocol for the PHOENIX randomised controlled trial. BMC Musculoskeletal Disorders, 23 (1) 361. doi: 10.1186/s12891-022-05282-0
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Journal Article: Balance control in unstable sitting in individuals with an acute episode of low back pain
van den Hoorn, Wolbert, Meroni, Roberto, Klyne, David M., Alshehri, Mansour Abdullah and Hodges, Paul W. (2022). Balance control in unstable sitting in individuals with an acute episode of low back pain. Gait and Posture, 95, 15-21. doi: 10.1016/j.gaitpost.2022.03.014
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Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2022). Postural control of the trunk in individuals with and without low back pain during unstable sitting: A protocol for a systematic review with an individual participant data meta-analysis. PLOS ONE, 17 (5), e0268381. doi: 10.1371/journal.pone.0268381
Grants
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Understanding Acute to Chronic Back Pain Pathways and Testing New Solutions
(2020–2023) Chronic Pain Management Research Program
Supervision
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Relationship between motor control of the trunk and recurrence/persistence of low back pain
Doctor Philosophy
Available Projects
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Disentangling the relationship between sleep and pain
We are seeking PhD students with a background in biomedical and/or rehabilitative sciences to join our team to contribute to a body of work that aims to identify if and how sleep influences pain. Projects will involve the measurement and analysis of sleep in the “real world” to understand how daily variations in sleep – one of the most important, yet modifiable health behaviors – drive the day-to-day “waxing and waning” of back pain. The work will involve a multidisciplinary team to address this challenging issue.
Essential criteria: An undergraduate degree with first or second class division 1 Honours in biomedical science, physiotherapy or a related discipline; eligibility for admission to the PhD program at The University of Queensland; knowledge of pain physiology; experience with statistical programs for data analysis; excellent communication skills (written and verbal) in English.
Publications
Journal Article
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Hall, Michelle, Allison, Kim, Hinman, Rana S., Bennell, Kim L., Spiers, Libby, Knox, Gabrielle, Plinsinga, Melanie, Klyne, David M., McManus, Fiona, Lamb, Karen E., Da Costa, Ricardo, Murphy, Nicholas J. and Dobson, Fiona L. (2022). Effects of adding aerobic physical activity to strengthening exercise on hip osteoarthritis symptoms: protocol for the PHOENIX randomised controlled trial. BMC Musculoskeletal Disorders, 23 (1) 361. doi: 10.1186/s12891-022-05282-0
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Balance control in unstable sitting in individuals with an acute episode of low back pain
van den Hoorn, Wolbert, Meroni, Roberto, Klyne, David M., Alshehri, Mansour Abdullah and Hodges, Paul W. (2022). Balance control in unstable sitting in individuals with an acute episode of low back pain. Gait and Posture, 95, 15-21. doi: 10.1016/j.gaitpost.2022.03.014
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Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2022). Postural control of the trunk in individuals with and without low back pain during unstable sitting: A protocol for a systematic review with an individual participant data meta-analysis. PLOS ONE, 17 (5), e0268381. doi: 10.1371/journal.pone.0268381
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Risk factors for low back pain outcome: Does it matter when they are measured?
Klyne, David Murray, Hall, Leanne Marie, Nicholas, Michael K. and Hodges, Paul William (2022). Risk factors for low back pain outcome: Does it matter when they are measured?. European Journal of Pain, 26 (4), 835-854. doi: 10.1002/ejp.1911
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Klyne, David M., Barbe, Mary F. and Hodges, Paul W. (2022). Relationship between systemic inflammation and recovery over 12 months after an acute episode of low back pain. The Spine Journal, 22 (2), 214-225. doi: 10.1016/j.spinee.2021.09.006
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Klyne, David M., Barbe, Mary F., James, Greg and Hodges, Paul W. (2021). Does the interaction between local and systemic inflammation provide a link from psychology and lifestyle to tissue health in musculoskeletal conditions?. International Journal of Molecular Sciences, 22 (14) 7299, 1-21. doi: 10.3390/ijms22147299
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Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2021). Coordination of hip and spine to maintain equilibrium in unstable sitting revealed by spectral analysis. Journal of Neurophysiology, 125 (5), 1814-1824. doi: 10.1152/jn.00555.2020
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Cohort profile: why do people keep hurting their back?
Klyne, David M., van den Hoorn, Wolbert, Barbe, Mary F., Cholewicki, Jacek, M. Hall, Leanne, Khan, Asaduzzaman, Meroni, Roberto, Moseley, G. Lorimer, Nicholas, Michael, O’Sullivan, Lee, Park, Rachel, Russell, Glen, Sterling, Michele and Hodges, Paul W. (2020). Cohort profile: why do people keep hurting their back?. BMC Research Notes, 13 (1) 538, 538. doi: 10.1186/s13104-020-05356-z
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Trunk stiffness decreases and trunk damping increases with experimental low back pain
van den Hoorn, Wolbert, Cholewicki, Jacek, Coppieters, Michel W., Klyne, David M. and Hodges, Paul W. (2020). Trunk stiffness decreases and trunk damping increases with experimental low back pain. Journal of Biomechanics, 112 110053, 110053. doi: 10.1016/j.jbiomech.2020.110053
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Barbe, Mary F., Hilliard, Brendan A., Amin, Mamta, Harris, Michele Y., Hobson, Lucas J., Cruz, Geneva E., Dorotan, Jocelynne T., Paul, Ryan W., Klyne, David M. and Popoff, Steven N. (2020). Blocking CTGF/CCN2 reverses neural fibrosis and sensorimotor declines in a rat model of overuse-induced median mononeuropathy. Journal of Orthopaedic Research, 38 (11) jor.24709, 2396-2408. doi: 10.1002/jor.24709
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Circulating adipokines in predicting the transition from acute to persistent low back pain
Klyne, David M. and Hodges, Paul W. (2020). Circulating adipokines in predicting the transition from acute to persistent low back pain. Pain Medicine, 21 (11), 2975-2985. doi: 10.1093/pm/pnaa052
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Smith, Tianqi Tenchi Gao, Barr-Gillespie, Ann E, Klyne, David M, Harris, Michelle Y, Amin, Mamta, Paul, Ryan W, Cruz, Geneva E, Zhao, Huaqing, Gallagher, Sean and Barbe, Mary F (2020). Forced treadmill running reduces systemic inflammation yet worsens upper limb discomfort in a rat model of work-related musculoskeletal disorders. BMC Musculoskeletal Disorders, 21 (1) 57, 57. doi: 10.1186/s12891-020-3085-z
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Klyne, David M. and Hodges, Paul W. (2019). Letter to the editor concerning “Multiple confounders influence the association between low-grade systemic inflammation and musculoskeletal pain. A call for a prudent interpretation of the literature” by Schipholt et al. Spine Journal, 19 (11), 1899-1900. doi: 10.1016/j.spinee.2019.06.011
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Are signs of central sensitisation in acute low back pain a precursor to poor outcome?
Klyne, David M., Moseley, G. Lorimer, Sterling, Michele, Barbe, Mary F. and Hodges, Paul W. (2019). Are signs of central sensitisation in acute low back pain a precursor to poor outcome?. The Journal of Pain, 20 (8), 994-1009. doi: 10.1016/j.jpain.2019.03.001
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James, G., Klyne, D. M., Millecamps, M., Stone, L. S. and Hodges, P. W. (2019). ISSLS Prize in Basic science 2019: physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration. European Spine Journal, 28 (5), 893-904. doi: 10.1007/s00586-019-05902-9
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Klyne, David M., Moseley, G. Lorimer, Sterling, Michele, Barbe, Mary F. and Hodges, Paul W. (2018). Individual variation in pain sensitivity and conditioned pain modulation in acute low back pain: impact of stimulus type, sleep, psychological and lifestyle factors. The Journal of Pain, 19 (8), 942.e1-942.e18. doi: 10.1016/j.jpain.2018.02.017
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Klyne, David M., Barbe, Mary F, van den Hoorn, Wolbert and Hodges, Paul W. (2018). ISSLS Prize in clinical science 2018: Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode-the good, the bad, and the ugly. European Spine Journal, 27 (4), 763-777. doi: 10.1007/s00586-018-5490-7
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Klyne, David M., Barbe, Mary F. and Hodges, Paul W. (2017). Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain. Brain, Behavior, and Immunity, 60, 84-92. doi: 10.1016/j.bbi.2016.10.003
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Effect of types and anatomical arrangement of painful stimuli on conditioned pain modulation
Klyne, David M., Schmid, Annina B., Moseley, G. Lorimer, Sterling, Michele and Hodges Paul W. (2015). Effect of types and anatomical arrangement of painful stimuli on conditioned pain modulation. Journal of Pain, 16 (2), 176-185. doi: 10.1016/j.jpain.2014.11.005
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Klyne, David M., Keays, Susan L., Bullock-Saxton, Joanne E. and Newcombe, Peter A. (2012). The effect of anterior cruciate ligament rupture on the timing and amplitude of gastrocnemius muscle activation: A study of alterations in EMG measures and their relationship to knee joint stability. Journal of Electromyography and Kinesiology, 22 (3), 446-455. doi: 10.1016/j.jelekin.2012.01.013
Conference Publication
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Klyne, D. M. (2019). Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode—the good, the bad, and the ugly. PsychoNeuroImmunology Research Society's 25th Annual Scientific Meeting, Miami Beach, FL, United States, 6-9 June 2018. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.bbi.2018.11.244
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Klyne, David, Barbe, Mary, Van Den Hoorn, Wolbert and Hodges, Paul (2018). Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode: a potential factor in tissue effects in low back pain. 5th International Fascia Research Congress, Berlin, Germany, 14-15 November 2018. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jbmt.2018.09.056
Other Outputs
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Mansour Abdullah Alshehri, Wolbert van den Hoorn, David M. Klyne and Paul W. Hodges (2021). Supplemental Data for "Coordination of hip and spine to maintain equilibrium in unstable sitting revealed by spectral analysis" paper. The University of Queensland. (Dataset) doi: 10.14264/c3f49b3
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Biological factors in the transition from acute to persistent low back pain
Klyne, David Murray (2018). Biological factors in the transition from acute to persistent low back pain. PhD Thesis, School of Health and Rehabilitation Sciences, The University of Queensland. doi: 10.14264/uql.2018.468
Grants (Administered at UQ)
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Understanding Acute to Chronic Back Pain Pathways and Testing New Solutions
(2020–2023) Chronic Pain Management Research Program
PhD and MPhil Supervision
Current Supervision
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Relationship between motor control of the trunk and recurrence/persistence of low back pain
Doctor Philosophy — Associate Advisor
Other advisors:
Possible Research Projects
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
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Disentangling the relationship between sleep and pain
We are seeking PhD students with a background in biomedical and/or rehabilitative sciences to join our team to contribute to a body of work that aims to identify if and how sleep influences pain. Projects will involve the measurement and analysis of sleep in the “real world” to understand how daily variations in sleep – one of the most important, yet modifiable health behaviors – drive the day-to-day “waxing and waning” of back pain. The work will involve a multidisciplinary team to address this challenging issue.
Essential criteria: An undergraduate degree with first or second class division 1 Honours in biomedical science, physiotherapy or a related discipline; eligibility for admission to the PhD program at The University of Queensland; knowledge of pain physiology; experience with statistical programs for data analysis; excellent communication skills (written and verbal) in English.
