Dr Anne-Sophie Bergot

Research Fellow

The University of Queensland Diamantina Institute
Faculty of Medicine

Overview

After receiving a PhD on immune regulation from La Sorbonne Universitas in France, Anne-Sophie joined Prof. Ian Frazer’s lab in Australia to study the mechanisms of immune tolerance in human papillomavirus-associated cancerous lesions in mice. She then joined the field of autoimmune diseases with Prof. Ranjeny Thomas. In Type 1 Diabetes, her pre-clinical data showed the feasibility of an antigen-specific liposome targeted immunotherapy in pre-diabetic mice and led to the first-in-human clinical trial using liposome nanoparticles. In Spondyloarthropathy, her interest is focused on deciphering the link between the gut microbiome, the immune system and the development of arthritic inflammation.

Research Interests

  • Link the bugs in the gut with arthritis in SkG mice and in SpA patients
    IL-23 dependent spondylitis, arthritis and ileitis recapitulate human spondyloarthropathy (SpA) in 1,3-beta-glucan (curdlan)-treated SKG mice. Human SpA patients and SKG mice have fecal dysbiosis, with increased gram-negative Bacteroidaceae and Porphyromonadaceae. In SKG mice, anti-IL-23 therapy supports homeostatic bacteria and gut integrity and is sufficient to prevent the development of arthritis. So I'm interested to know how pathobionts and commensals impact the development of SpA using the SKG mouse model. My current interest is also to confirm my findings in human patients with SpA who have simultaenous gut inflammation or not. Cool tools = germ-free mice, bacteria (anaerobic, aerobic) cultures, fluorescence in situ hybridization (FISH), confocal imaging, FACS analysis, genomic work Questions = -How do the bacteria get to the inflammed joint? -Is this a cause of inflammation or are they attracted there as a consequence of in situ inflammation? -Are gut bacteria cargo-ed from one site to another and which cell can do that? -Is this part of a defective clearance mechanism ? -Are bacteria or gargo-ed bacteria circulating through blood vessels? -How can this be prevented?

Qualifications

  • Doctor of Philosophy, University of Paris 6 - Pierre and Marie Curie University

Publications

  • Giri, Rabina, Hoedt, Emily C., Khushi, Shamsunnahar, Salim, Angela A., Bergot, Anne-Sophie, Schreiber, Veronika, Thomas, Ranjeny, McGuckin, Michael A., Florin, Timothy H., Morrison, Mark, Capon, Robert J., Ó Cuív, Páraic and Begun, Jakob (2022). Secreted NF-κB suppressive microbial metabolites modulate gut inflammation. Cell Reports, 39 (2) 110646, 110646. doi: 10.1016/j.celrep.2022.110646

  • Buckle, Irina, Loaiza Naranjo, Jeniffer D., Bergot, Anne-Sophie, Zhang, Vivian, Talekar, Meghna, Steptoe, Raymond J., Thomas, Ranjeny and Hamilton-Williams, Emma E. (2021). Tolerance induction by liposomes targeting a single CD8 epitope IGRP in a model of type 1 diabetes is impeded by co-targeting a CD4 islet epitope. Immunology and Cell Biology, 100 (1), 33-48. doi: 10.1111/imcb.12506

  • Guggino, Giuliana, Mauro, Daniele, Rizzo, Aroldo, Alessandro, Riccardo, Raimondo, Stefania, Bergot, Anne-Sophie, Rahman, M Arifur, Ellis, Jonathan J., Milling, Simon, Lories, Rik, Elewaut, Dirk, Brown, Matthew A., Thomas, Ranjeny and Ciccia, Francesco (2021). Inflammasome activation in ankylosing spondylitis is associated to gut dysbiosis. Arthritis and Rheumatology, 73 (7) art.41644, 1189-1199. doi: 10.1002/art.41644

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Journal Article

Conference Publication

PhD and MPhil Supervision

Current Supervision