The University of Queensland

A Sub-6 nm MnFe2O4-dichloroacetic acid nanocomposite modulates tumor metabolism and catabolism for reversing tumor immunosuppressive microenvironment and boosting immunotherapy

Dai, Zan, Wang, Qiaoyun, Tang, Jie, Qu, Rui, Wu, Min, Li, Haoze, Yang, Yannan, Zhen, Xu and Yu, Chengzhong (2022). A Sub-6 nm MnFe2O4-dichloroacetic acid nanocomposite modulates tumor metabolism and catabolism for reversing tumor immunosuppressive microenvironment and boosting immunotherapy. Biomaterials, 284 121533, 121533. doi: 10.1016/j.biomaterials.2022.121533

Nanotechnologies in delivery of DNA and mRNA vaccines to the nasal and pulmonary mucosa

Tang, Jie, Cai, Larry, Xu, Chuanfei, Sun, Si, Liu, Yuheng, Rosenecker, Joseph and Guan, Shan (2022). Nanotechnologies in delivery of DNA and mRNA vaccines to the nasal and pulmonary mucosa. Nanomaterials, 12 (2) 226, 226. doi: 10.3390/nano12020226

Immune-regulating bimetallic metal-organic framework nanoparticles designed for cancer immunotherapy

Dai, Zan, Wang, Qiaoyun, Tang, Jie, Wu, Min, Li, Haoze, Yang, Yannan, Zhen, Xu and Yu, Chengzhong (2021). Immune-regulating bimetallic metal-organic framework nanoparticles designed for cancer immunotherapy. Biomaterials, 280 121261, 121261. doi: 10.1016/j.biomaterials.2021.121261

Biomimetic inorganic-organic hybrid nanoparticles from magnesium-substituted amorphous calcium phosphate clusters and polyacrylic acid molecules

Li, Na, Cui, Wei, Cong, Peifang, Tang, Jie, Guan, Yong, Huang, Caihao, Liu, Yunen, Yu, Chengzhong, Yang, Rui and Zhang, Xing (2021). Biomimetic inorganic-organic hybrid nanoparticles from magnesium-substituted amorphous calcium phosphate clusters and polyacrylic acid molecules. Bioactive Materials, 6 (8), 2303-2314. doi: 10.1016/j.bioactmat.2021.01.005

Ferroptosis-strengthened metabolic and inflammatory regulation of tumor-associated macrophages provokes potent tumoricidal activities

Gu, Zhengying, Liu, Tianqing, Liu, Chao, Yang, Yannan, Tang, Jie, Song, Hao, Wang, Yue, Yang, Yang and Yu, Chengzhong (2021). Ferroptosis-strengthened metabolic and inflammatory regulation of tumor-associated macrophages provokes potent tumoricidal activities. Nano Letters, 21 (15) acs.nanolett.1c01401, 6471-6479. doi: 10.1021/acs.nanolett.1c01401

Synthesis of γ-Keto Sulfones through a Three-Component Reaction of Cyclopropanols, DABCO ⋅ (SO2)2 and Alkyl Halides

Zhang, Chun, Zhang, Chao, Tang, Jie, Ye, Shengqing, Ma, Mingliang and Wu, Jie (2021). Synthesis of γ-Keto Sulfones through a Three-Component Reaction of Cyclopropanols, DABCO ⋅ (SO2)2 and Alkyl Halides. Advanced Synthesis and Catalysis, 363 (12), 3109-3114. doi: 10.1002/adsc.202100066

MnO2 nanoflowers induce immunogenic cell death under nutrient deprivation: enabling an orchestrated cancer starvation-immunotherapy

Yang, Yannan, Gu, Zhengying, Tang, Jie, Zhang, Min, Yang, Yang, Song, Hao and Yu, Chengzhong (2021). MnO2 nanoflowers induce immunogenic cell death under nutrient deprivation: enabling an orchestrated cancer starvation-immunotherapy. Advanced Science, 8 (4) 2002667, 1-10. doi: 10.1002/advs.202002667

A general strategy to design highly fluorogenic far-red and near-infrared tetrazine bioorthogonal probes

Mao, Wuyu, Tang, Jie, Dai, Liqun, He, Xinyu, Li, Jie, Cai, Larry, Liao, Ping, Jiang, Ruotian, Zhou, Jingwei and Wu, Haoxing (2021). A general strategy to design highly fluorogenic far-red and near-infrared tetrazine bioorthogonal probes. Angewandte Chemie-International Edition, 60 (5), 2393-2397. doi: 10.1002/anie.202011544

Openwork@Dendritic mesoporous silica nanoparticles for lactate depletion and tumor microenvironment regulation

Tang, Jie, Meka, Anand Kumar, Theivendran, Shevanuja, Wang, Yue, Yang, Yannan, Song, Hao, Fu, Jianye, Ban, Wenhuang, Gu, Zhengying, Lei, Chang, Li, Shumin and Yu, Chengzhong (2020). Openwork@Dendritic mesoporous silica nanoparticles for lactate depletion and tumor microenvironment regulation. Angewandte Chemie International Edition, 59 (49) anie.202001469, 22054-22062. doi: 10.1002/anie.202001469

Confined growth of ZIF-8 in dendritic mesoporous organosilica nanoparticles as bio-regulators for enhanced mRNA delivery in vivo

Wang, Yue, Song, Hao, Liu, Chao, Zhang, Ye, Kong, Yueqi, Tang, Jie, Yang, Yannan and Yu, Chengzhong (2020). Confined growth of ZIF-8 in dendritic mesoporous organosilica nanoparticles as bio-regulators for enhanced mRNA delivery in vivo. National Science Review, 8 (8) nwaa268, 1-10. doi: 10.1093/nsr/nwaa268

Dendritic mesoporous silica nanoparticle adjuvants modified with binuclear aluminum complex: coordination chemistry dictates adjuvanticity

Yang, Yang, Tang, Jie, Song, Hao, Yang, Yannan, Gu, Zhengying, Fu, Jianye, Liu, Yang, Zhang, Min, Qiao, Zhen‐An and Yu, Chengzhong (2020). Dendritic mesoporous silica nanoparticle adjuvants modified with binuclear aluminum complex: coordination chemistry dictates adjuvanticity. Angewandte Chemie International Edition, 59 (44), 19610-19617. doi: 10.1002/anie.202006861

Eliciting immunogenic cell death via a unitized nanoinducer

Dai, Zan, Tang, Jie, Gu, Zhengying, Wang, Yue, Yang, Yang, Yang, Yannan and Yu, Chengzhong (2020). Eliciting immunogenic cell death via a unitized nanoinducer. Nano Letters, 20 (9), 6246-6254. doi: 10.1021/acs.nanolett.0c00713

Functional nanoparticles with a reducible tetrasulfide motif to upregulate mRNA translation and enhance transfection in hard-to-transfect cells

Wang, Yue, Tang, Jie, Yang, Yannan, Song, Hao, Fu, Jianye, Gu, Zhengying and Yu, Chengzhong (2020). Functional nanoparticles with a reducible tetrasulfide motif to upregulate mRNA translation and enhance transfection in hard-to-transfect cells. Angewandte Chemie International Edition, 132 (7) ange.201914264, 2717-2721. doi: 10.1002/anie.201914264

Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment

Theivendran, Shevanuja, Tang, Jie, Lei, Chang, Yang, Yannan, Song, Hao, Gu, Zhengying, Wang, Yue, Yang, Yang, Jin, Lei and Yu, Chengzhong (2020). Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment. Chemical Science, 11 (38), 10421-10430. doi: 10.1039/d0sc02803g

Fractal-in-a-sphere: confined self-assembly of fractal silica nanoparticles

Fu, Jianye, Jiao, Jinqing, Song, Hao, Gu, Zhengying, Liu, Yang, Geng, Jing, Jack, Kevin S., Du, Ai, Tang, Jie and Yu, Chengzhong (2019). Fractal-in-a-sphere: confined self-assembly of fractal silica nanoparticles. Chemistry of Materials, 32 (1) acs.chemmater.9b03864, 341-347. doi: 10.1021/acs.chemmater.9b03864

DNA vaccine mediated by rambutan‐like mesoporous silica nanoparticles

Song, Hao, Yang, Yannan, Tang, Jie, Gu, Zhengying, Wang, Yue, Zhang, Min and Yu, Chengzhong (2019). DNA vaccine mediated by rambutan‐like mesoporous silica nanoparticles. Advanced Therapeutics, 3 (1) 1900154, 1900154. doi: 10.1002/adtp.201900154

Responsively aggregatable sub-6 nm nanochelators induce simultaneous antiangiogenesis and vascular obstruction for enhanced tumor vasculature targeted therapy

Yang, Yannan, Tang, Jie, Zhang, Min, Gu, Zhengying, Song, Hao, Yang, Yang and Yu, Chengzhong (2019). Responsively aggregatable sub-6 nm nanochelators induce simultaneous antiangiogenesis and vascular obstruction for enhanced tumor vasculature targeted therapy. Nano Letters, 19 (11), 7750-7759. doi: 10.1021/acs.nanolett.9b02691

Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy

Tang, Jie, Li, Bei, Howard, Christopher B., Mahler, Stephen M., Thurecht, Kristofer J., Wu, Yilun, Huang, Leaf and Xu, Zhi Ping (2019). Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy. Biomaterials, 216 119232, 119232. doi: 10.1016/j.biomaterials.2019.119232

Mechanism of iron oxide-induced macrophage activation: the impact of composition and the underlying signaling pathway

Gu, Zhengying, Liu, Tianqing, Tang, Jie, Yang, Yannan, Song, Hao, Tuong, Zewen K., Fu, Jianye and Yu, Chengzhong (2019). Mechanism of iron oxide-induced macrophage activation: the impact of composition and the underlying signaling pathway. Journal of the American Chemical Society, 141 (15) jacs.8b10904, 6122-6126. doi: 10.1021/jacs.8b10904

Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations

Fu, Jianye, Gu, Zhengying, Liu, Yang, Zhang, Jun, Song, Hao, Yang, Yannan, Yang, Yang, Noonan, Owen, Tang, Jie and Yu, Chengzhong (2019). Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations. Chemical Science, 10 (44), 10388-10394. doi: 10.1039/c9sc02961c

Novel theranostic nanoplatform for complete mice tumor elimination via MR imaging-guided acid-enhanced photothermo-/chemo-therapy

Li, Bei, Tang, Jie, Chen, Weiyu, Hao, Guanyu, Kurniawan, Nyoman, Gu, Zi and Xu, Zhi Ping (2018). Novel theranostic nanoplatform for complete mice tumor elimination via MR imaging-guided acid-enhanced photothermo-/chemo-therapy. Biomaterials, 177, 40-51. doi: 10.1016/j.biomaterials.2018.05.055

Hybrid nanoreactors: enabling an off-the-shelf strategy for concurrently enhanced chemo-immunotherapy

Yang, Yannan, Tang, Jie, Abbaraju, Prasanna Lakshmi, Jambhrunkar, Manasi, Song, Hao, Zhang, Min, Lei, Chang, Fu, Jianye, Gu, Zhengying, Liu, Yang and Yu, Chengzhong (2018). Hybrid nanoreactors: enabling an off-the-shelf strategy for concurrently enhanced chemo-immunotherapy. Angewandte Chemie, 130 (36), 11938-11943. doi: 10.1002/ange.201807595

Kinetically controlled dendritic mesoporous silica nanoparticles: from dahlia- to pomegranate-like structures by micelle filling

Wang, Yue, Song, Hao, Yang, Yannan, Liu, Yang, Tang, Jie and Yu, Chengzhong (2018). Kinetically controlled dendritic mesoporous silica nanoparticles: from dahlia- to pomegranate-like structures by micelle filling. Chemistry of Materials, 30 (16) acs.chemmater.8b02712, 5770-5776. doi: 10.1021/acs.chemmater.8b02712

Hybrid nanoreactors enable an off-the-shelf strategy for concurrently enhanced chemo-immunotherapy

Yang, Yannan, Tang, Jie, Abbaraju, Prasanna Lakshmi, Jambhrunkar, Manasi, Song, Hao, Zhang, Min, Lei, Chang, Fu, Jianye, Gu, Zhengying, Liu, Yang and Yu, Chengzhong (2018). Hybrid nanoreactors enable an off-the-shelf strategy for concurrently enhanced chemo-immunotherapy. Angewandte Chemie, 57 (36), 11764-11769. doi: 10.1002/anie.201807595

Stepwise degradable nanocarriers enabled cascade delivery for synergistic cancer therapy

Yang, Yannan, Lu, Yao, Abbaraju, Prasanna Lakshmi, Azimi, Iman, Lei, Chang, Tang, Jie, Jambhrunkar, Manasi, Fu, Jianye, Zhang, Min, Liu, Yang, Liu, Chao and Yu, Chengzhong (2018). Stepwise degradable nanocarriers enabled cascade delivery for synergistic cancer therapy. Advanced Functional Materials, 28 (28) 1800706, 1800706. doi: 10.1002/adfm.201800706

Enhanced delivery of siRNA to triple negative breast cancer cells in vitro and in vivo through functionalizing lipid-coated calcium phosphate nanoparticles with dual target ligands

Tang, Jie, Howard, Christopher B., Mahler, Stephen M., Thurecht, Kristofer J., Huang, Leaf and Xu, Zhi Ping (2018). Enhanced delivery of siRNA to triple negative breast cancer cells in vitro and in vivo through functionalizing lipid-coated calcium phosphate nanoparticles with dual target ligands. Nanoscale, 10 (9), 4258-4266. doi: 10.1039/c7nr08644j

Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance

Wang, Yue, Song, Hao, Yu, Meihua, Xu, Chun, Liu, Yang, Tang, Jie, Yang, Yannan and Yu, Chengzhong (2018). Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance. Journal of Materials Chemistry B, 6 (24), 4089-4095. doi: 10.1039/c8tb00544c

Devising new lipid-coated calcium phosphate/carbonate hybrid nanoparticles for controlled release in endosomes for efficient gene delivery

Wu, Yilun, Gu, Wenyi, Tang, Jie and Xu, Zhi Ping (2017). Devising new lipid-coated calcium phosphate/carbonate hybrid nanoparticles for controlled release in endosomes for efficient gene delivery. Journal of Materials Chemistry B, 5 (34), 7194-7203. doi: 10.1039/c7tb01635b

Preparation of optimized lipid-coated calcium phosphate nanoparticles for enhanced in vitro gene delivery to breast cancer cells

Tang, Jie, Li, Li, Howard, Christopher B., Mahler, Stephen M., Huang, Leaf and Xu, Zhi Ping (2015). Preparation of optimized lipid-coated calcium phosphate nanoparticles for enhanced in vitro gene delivery to breast cancer cells. Journal of Materials Chemistry B, 3 (33), 6805-6812. doi: 10.1039/c5tb00912j

Antitumor effects of MsurvivinT34A-CaPi complex-embedded PLGA nanoparticles in combination with Doxil in mice

Tang, Jie, He, Jinfeng, Yang, Chengli, Mao, Yi, Hu, Tingting, Zhang, Lijing, Cao, Hua, Tong, Ai-ping, Song, Xiangrong, He, Gu, Guo, Gang, Luo, Youfu, Zhang, Xiaoning, Xie, Yongmei and Zheng, Yu (2014). Antitumor effects of MsurvivinT34A-CaPi complex-embedded PLGA nanoparticles in combination with Doxil in mice. Journal of Nanoparticle Research, 16 (11). doi: 10.1007/s11051-014-2682-x

Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting

Liu, Yayuan, Ran, Rui, Chen, Jiantao, Kuang, Qifang, Tang, Jie, Mei, Ling, Zhang, Qianyu, Gao, Huile, Zhang, Zhirong and He, Qin (2014). Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting. Biomaterials, 35 (17), 4835-4847. doi: 10.1016/j.biomaterials.2014.02.031

Preparation and in vitro evaluation of pDNA-CaPi-PLGA nanoparticles with a core-shell structure

Tang, Jie, Liu, Jing, Hu, Ting-Ting, Yang, Cheng-Li, Guo, Gang, He, Gu, Huang, Yuan and Zheng, Yu (2013). Preparation and in vitro evaluation of pDNA-CaPi-PLGA nanoparticles with a core-shell structure. Yaoxue Xuebao, 48 (2), 298-304.

Semi-synthesis and biological evaluation of 1,2,3-triazole-based podophyllotoxin congeners as potent antitumor agents inducing apoptosis in HepG2 cells

Chen, Jinying, Ma, Liang, Zhang, Ronghong, Tang, Jie, Lai, Huijun, Wang, Jun, Wang, Guangcheng, Xu, Qinyuan, Chen, Tao, Peng, Fei, Qiu, Jingxiang, Liang, Xiaolin, Cao, Dong, Ran, Yan, Peng, Aihua, Wei, Yuquan and Chen, Lijuan (2012). Semi-synthesis and biological evaluation of 1,2,3-triazole-based podophyllotoxin congeners as potent antitumor agents inducing apoptosis in HepG2 cells. Archiv der Pharmazie, 345 (12), 945-956. doi: 10.1002/ardp.201100438

Calcium phosphate embedded PLGA nanoparticles: a promising gene delivery vector with high gene loading and transfection efficiency

Tang, Jie, Chen, Jin-Ying, Liu, Jing, Luo, Min, Wang, Ying-Jing, Wei, Xia-wei, Gao, Xiang, Wang, Bi-lan, Liu, Yi-Bo, Yi, Tao, Tong, Ai-Ping, Song, Xiang-Rong, Xie, Yong-Mei, Zhao, Yinglan, Xiang, Mingli, Huang, Yuan and Zheng, Yu (2012). Calcium phosphate embedded PLGA nanoparticles: a promising gene delivery vector with high gene loading and transfection efficiency. International Journal of Pharmaceutics, 431 (1-2), 210-221. doi: 10.1016/j.ijpharm.2012.04.046

Preparation of the thienopyridine derivatives loaded liposomes and study on the effect of compound-lipid interaction on release behavior

Liu, Jing, Tang, Jie, He, Haiyun, Cai, Lu-Lu, Huang, YiMei, Wei, Xiawei, Luo, Min, Wang, Bilan, Gao, Xiang, Yang, Chengli, Hu, Tingting, Song, Xiangrong, Yi, Tao, Yang, Li, Xie, Yongmei, Tong, Aiping, Gou, Lantu, Zhao, Yinglan and Zheng, Yu (2012). Preparation of the thienopyridine derivatives loaded liposomes and study on the effect of compound-lipid interaction on release behavior. Drug Delivery, 19 (5), 247-254. doi: 10.3109/10717544.2012.699983

(E)-3-(4-Chlorophenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1one

Tang, Jie, Chen, Jin-ying and Jiang, Ling-qun (2012). (E)-3-(4-Chlorophenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1one. Acta Crystallographica Section E: Crystallographic Communications, 68 (2), o278-sup-8. doi: 10.1107/s1600536811055255

Targeted delivery of cargoes into a murine solid tumor by a cell-penetrating peptide and cleavable poly(ethylene glycol) comodified liposomal delivery system via systemic administration

Kuai, Rui, Yuan, Wenmin, Li, Wanyu, Qin, Yao, Tang, Jie, Yuan, Mingqing, Fu, Ling, Ran, Rui, Zhang, Zhirong and He, Qin (2011). Targeted delivery of cargoes into a murine solid tumor by a cell-penetrating peptide and cleavable poly(ethylene glycol) comodified liposomal delivery system via systemic administration. Molecular Pharmaceutics, 8 (6), 2151-2161. doi: 10.1021/mp200100f

Engineering lipid-coated calcium phosphate nanoparticles with multiple ligands to amplify in vivo tumor target delivery

Tang, Jie (2018). Engineering lipid-coated calcium phosphate nanoparticles with multiple ligands to amplify in vivo tumor target delivery. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland. doi: 10.14264/uql.2018.411