The University of Queensland

Reflections on Navigating a Pandemic: Perspectives from the Chemical Biology Community

Conibear, Anne C. and Hartrampf, Nina (2023). Reflections on Navigating a Pandemic: Perspectives from the Chemical Biology Community. ChemBioChem, 24 (14) e202300258. doi: 10.1002/cbic.202300258

Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR

Kuschert, Sarah, Stroet, Martin, Chin, Yanni Ka-Yan, Conibear, Anne Claire, Jia, Xinying, Lee, Thomas, Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Güntert, Peter, Rosengren, Karl Johan, Mark, Alan Edward and Mobli, Mehdi (2023). Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR. Magnetic Resonance, 4 (1), 57-72. doi: 10.5194/mr-4-57-2023

A conserved β‐bulge glycine residue facilitates folding and increases stability of the mouse α‐defensin cryptdin‐4

Clark, Richard J., Phan, Thanh Huyen, Song, Angela, Ouellette, André J., Conibear, Anne C. and Rosengren, K. Johan (2021). A conserved β‐bulge glycine residue facilitates folding and increases stability of the mouse α‐defensin cryptdin‐4. Peptide Science, 114 (1) e24250. doi: 10.1002/pep2.24250

Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins

Vogl, Dominik P., Conibear, Anne C. and Becker, Christian F. W. (2021). Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins. RSC Chemical Biology, 2 (5), 1441-1461. doi: 10.1039/d1cb00045d

Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding

Ho, Thao N. T., Lee, Han Siean, Swaminathan, Shilpa, Goodwin, Lewis, Rai, Nishant, Ushay, Brianna, Lewis, Richard J., Rosengren, K. Johan and Conibear, Anne C. (2021). Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. RSC Medicinal Chemistry, 12 (9), 1574-1584. doi: 10.1039/d1md00182e

Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications

Niederacher, Gerhard, Urwin, Debra, Dijkwel, Yasmin, Tremethick, David J., Rosengren, K. Johan, Becker, Christian F. W. and Conibear, Anne C. (2021). Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications. RSC Chemical Biology, 2 (2), 537-550. doi: 10.1039/d0cb00175a

Deciphering protein post-translational modifications using chemical biology tools

Conibear, Anne C. (2020). Deciphering protein post-translational modifications using chemical biology tools. Nature Reviews Chemistry, 4 (12), 674-695. doi: 10.1038/s41570-020-00223-8

Synthesis and anti-parasitic activity of achiral N-benzylated phosphoramidic acid derivatives

Adeyemi, Christiana M., Conibear, Anne C., Mutorwa, Marius K., Nokalipa, Iviwe C., Isaacs, Michelle, Mnkandhla, Dumisani, Hoppe, Heinrich C., Lobb, Kevin A., Klein, Rosalyn and Kaye, Perry T. (2020). Synthesis and anti-parasitic activity of achiral N-benzylated phosphoramidic acid derivatives. Bioorganic Chemistry, 101 103947, 103947. doi: 10.1016/j.bioorg.2020.103947

Random coil shifts of posttranslationally modified amino acids

Conibear, Anne C., Rosengren, K. Johan, Becker, Christian F. W. and Kaehlig, Hanspeter (2019). Random coil shifts of posttranslationally modified amino acids. Journal of Biomolecular NMR, 73 (10-11), 587-599. doi: 10.1007/s10858-019-00270-4

Tumor-targeting immune system engagers (ISErs) activate human neutrophils after binding to cancer cells

Pötgens, André J. G., Conibear, Anne C., Altdorf, Claudia, Hilzendeger, Clarissa and Becker, Christian F. W. (2019). Tumor-targeting immune system engagers (ISErs) activate human neutrophils after binding to cancer cells. Biochemistry, 58 (22) acs.biochem.9b00169, 2642-2652. doi: 10.1021/acs.biochem.9b00169

Multifunctional scaffolds for assembling cancer-targeting immune stimulators using chemoselective ligations

Conibear, Anne C., Thewes, Karine, Groysbeck, Nadja and Becker, Christian F.W. (2019). Multifunctional scaffolds for assembling cancer-targeting immune stimulators using chemoselective ligations. Frontiers in Chemistry, 7 (MAR) 113, 113. doi: 10.3389/fchem.2019.00113

Native chemical ligation in protein synthesis and semi-synthesis

Conibear, Anne C., Watson, Emma E., Payne, Richard J. and Becker, Christian F. W. (2018). Native chemical ligation in protein synthesis and semi-synthesis. Chemical Society Reviews, 47 (24), 9046-9068. doi: 10.1039/c8cs00573g

Synthetic cancer-targeting innate immune stimulators give insights into avidity effects

Conibear, Anne C., Poetgens, Andre J. G., Thewes, Karine, Altdorf, Claudia, Hilzendeger, Clarissa and Becker, Christian F. W. (2018). Synthetic cancer-targeting innate immune stimulators give insights into avidity effects. ChemBioChem, 19 (5), 459-469. doi: 10.1002/cbic.201700522

Synthetic integrin-binding immune stimulators target cancer cells and prevent tumor formation

Brehs, Manuel, Poetgens, Andre J. G., Steitz, Julia, Thewes, Karine, Schwarz, Janett, Conibear, Anne C., Bartneck, Matthias, Tacke, Frank and Becker, Christian F. W. (2017). Synthetic integrin-binding immune stimulators target cancer cells and prevent tumor formation. Scientific Reports, 7 (1) 17592, 17592. doi: 10.1038/s41598-017-17627-0

A comparative study of synthetic and semisynthetic approaches for ligating the epidermal growth factor to a bivalent scaffold

Gell, Anna Lena, Groysbeck, Nadja, Becker, Christian F. W. and Conibear, Anne C. (2017). A comparative study of synthetic and semisynthetic approaches for ligating the epidermal growth factor to a bivalent scaffold. Journal of Peptide Science, 23 (12), 871-879. doi: 10.1002/psc.3051

Recent Advances in Peptide-Based Approaches for Cancer Treatment

Conibear, Anne C., Schmid, Alanca, Kamalov, Meder, Becker, Christian F. W. and Bello, Claudia (2017). Recent Advances in Peptide-Based Approaches for Cancer Treatment. Current Medicinal Chemistry, 27 (8), 1174-1205. doi: 10.2174/0929867325666171123204851

Multifunctional alpha(v)beta(6) integrin-specific peptide-Pt(IV) conjugates for cancer cell targeting

Conibear, Anne C., Hager, Sonja, Mayr, Josef, Klose, Matthias H. M., Keppler, Bernhard K., Kowol, Christian R., Heffeter, Petra and Becker, Christian F. W. (2017). Multifunctional alpha(v)beta(6) integrin-specific peptide-Pt(IV) conjugates for cancer cell targeting. Bioconjugate Chemistry, 28 (9), 2429-2439. doi: 10.1021/acs.bioconjchem.7b00421

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

Kwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I. and Craik, David J. (2016). Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering, 113 (10), 2202-2212. doi: 10.1002/bit.25993

Arginine side-chain modification that occurs during copper-catalysed azide-alkyne click reactions resembles an advanced glycation end product

Conibear, Anne C., Farbiarz, Karine, Mayer, Rupert L., Matveenko, Maria, Kaehlig, Hanspeter and Becker, Christian F. W. (2016). Arginine side-chain modification that occurs during copper-catalysed azide-alkyne click reactions resembles an advanced glycation end product. Organic and Biomolecular Chemistry, 14 (26), 6205-6211. doi: 10.1039/c6ob00932h

Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties

Wang, Conan K., King, Gordon J., Conibear, Anne C., Ramos, Mariana C., Chaousis, Stephanie, Henriques, Sonia Troeira and Craik, David J. (2016). Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties. Journal of American Chemical Society, 138 (17), 5706-5713. doi: 10.1021/jacs.6b02575

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization

Conibear, Anne C., Chaousis, Stephanie, Durek, Thomas, Rosengren, K. Johan, Craik, David J. and Schroeder, Christina I. (2016). Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization. Biopolymers, 106 (1), 89-100. doi: 10.1002/bip.22767

Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxins

Akcan, Muharrem, Clark, Richard J., Daly, Norelle L., Conibear, Anne C., de Faoite, Andrew, Heghinian, Mari D., Sahil, Talwar, Adams, David J., Mari, Frank and Craik, David J. (2015). Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxins. Peptide Science, 104 (6), 682-692. doi: 10.1002/bip.22699

Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis

Conibear, Anne C., Wang, Conan K., Bi, Tao, Rosengren, K. Johan, Camarero, Julio A. and Craik, David J. (2014). Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis. Journal of Physical Chemistry B, 118 (49), 14257-14266. doi: 10.1021/jp507754c

The chemistry and biology of theta defensins

Conibear, Anne C. and Craik, David J. (2014). The chemistry and biology of theta defensins. Angewandte Chemie International Edition, 53 (40), 10612-10623. doi: 10.1002/anie.201402167

Chemie und Biologie von Theta-Defensinen

Conibear, Anne C. and Craik, David J. (2014). Chemie und Biologie von Theta-Defensinen. Angewandte Chemie, 126 (40), 10786-10798. doi: 10.1002/ange.201402167

The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif

Conibear, Anne C., Bochen, Alexander, Rosengren, K. Johan, Stupar, Petar, Wang, Conan, Kessler, Horst and Craik, David J. (2014). The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif. ChemBioChem, 15 (3), 451-459. doi: 10.1002/cbic.201300568

Exploring DOXP-reductoisomerase binding limits using phosphonated N-aryl and N-heteroarylcarboxamides as DXR inhibitors

Bodill, Taryn, Conibear, Anne C., Mutorwa, Marius K. M., Goble, Jessica L., Blatch, Gregory L., Lobb, Kevin A., Klein, Rosalyn and Kaye, Perry T. (2013). Exploring DOXP-reductoisomerase binding limits using phosphonated N-aryl and N-heteroarylcarboxamides as DXR inhibitors. Bioorganic and Medicinal Chemistry, 21 (14), 4332-4341. doi: 10.1016/j.bmc.2013.04.076

The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity

Conibear, Anne C., Rosengren, K. Johan, Daly, Norelle L., Henriques, Sonia Troeira and Craik, David J. (2013). The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity. Journal of Biological Chemistry, 288 (15), 10830-10840. doi: 10.1074/jbc.M113.451047

Structural characterization of the cyclic cystine ladder motif of θ-defensins

Conibear, Anne C., Rosengren, K. Johan, Harvey, Peta J. and Craik, David J. (2012). Structural characterization of the cyclic cystine ladder motif of θ-defensins. Biochemistry, 51 (48), 9718-9726. doi: 10.1021/bi301363a

Quantification of small cyclic disulfide-rich peptides

Conibear, Anne, Daly, Norelle L. and Craik, David J. (2012). Quantification of small cyclic disulfide-rich peptides. Biopolymers, 98 (6), 518-524. doi: 10.1002/bip.22121

Chemical Synthesis of Naturally-Occurring Cyclic Mini-Proteins from Plants and Animals

Conibear, Anne C. and Craik, David J. (2011). Chemical Synthesis of Naturally-Occurring Cyclic Mini-Proteins from Plants and Animals. Israel Journal of Chemistry, 51 (8-9), 908-916. doi: 10.1002/ijch.201100067

The chemistry of cyclotides

Craik, David J. and Conibear, Anne C. (2011). The chemistry of cyclotides. Journal of Organic Chemistry, 76 (12), 4805-4817. doi: 10.1021/jo200520v

Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors

Bodin, Taryn, Conibear, Anne C., Blatch, Gregory L., Lobb, Kevin A. and Kaye, Perry T. (2011). Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors. Bioorganic and Medicinal Chemistry, 19 (3), 1321-1327. doi: 10.1016/j.bmc.2010.11.062

P-31 NMR kinetic study of the tandem cleavage of phosphonate esters by bromotrimethylsilane

Conibear, Anne C., Lobb, Kevin A. and Kaye, Perry T. (2010). P-31 NMR kinetic study of the tandem cleavage of phosphonate esters by bromotrimethylsilane. Tetrahedron, 66 (43), 8446-8449. doi: 10.1016/j.tet.2010.08.058

Protein Chemistry Looking Ahead: 8th Chemical Protein Synthesis Meeting 16-19 June 2019, Berlin, Germany

Bello, Claudia, Hartrampf, Nina, Walport, Louise J. and Conibear, Anne C. (2019). Protein Chemistry Looking Ahead: 8th Chemical Protein Synthesis Meeting 16-19 June 2019, Berlin, Germany. 8th Chemical Protein Synthesis, Berlin, Germany, 16-19 June 2019. Cambridge, MA, United States: Cell Press. doi: 10.1016/j.chembiol.2019.09.011

Advancing the frontiers of chemical protein synthesis - the 7CPS meeting, Haifa, Israel

Conibear, Anne C. and Muttenthaler, Markus (2018). Advancing the frontiers of chemical protein synthesis - the 7CPS meeting, Haifa, Israel. Cambridge, MA, United States: Cell Press. doi: 10.1016/j.chembiol.2018.03.001

Characterisation and applications of theta-defensins

Conibear, Anne (2014). Characterisation and applications of theta-defensins. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/uql.2014.251