Dr Giorgia Mori

Postdoctoral Research Fellow

The University of Queensland Diamantina Institute
Faculty of Medicine

Overview

Dr. Giorgia Mori is a Molecular Microbiologist passionate about finding solutions that help address the global health emergency posed by tuberculosis (TB). Her work focuses on the characterization of new TB drug leads, in order to overcome the major limitations associated with the currently available TB treatments. She received her PhD in 2014 from the University of Pavia (UNIPV, Italy) and she has 5 years of postdoctoral experience in academic research and 8 months experience in an industry position, working as a Bioinformatician at the European Institute of Oncology (IEO, Italy).

In 2019, she relocated from Italy to Australia, to take up the opportunity to drive the pre-clinical characterization of a highly promising novel TB drug lead in an internationally funded program at the University of Queensland (UQ, A/Prof. Antje Blumenthal's lab) that brings together a multi-disciplinary international team of microbiologists, immunologists and chemists.

Publications

View all Publications

Publications

Journal Article

  • Av-Gay, Yossef, Mori, Giorgia and Pasca, Maria Rosalia (2021). Editorial: New Approaches Against Drug-Resistant M. tuberculosis. Frontiers in Microbiology, 12 681420, 681420. doi: 10.3389/fmicb.2021.681420

  • Mori, Giorgia, Morrison, Mark and Blumenthal, Antje (2021). Microbiome-immune interactions in tuberculosis. PLoS Pathogens, 17 (4) e1009377, e1009377. doi: 10.1371/journal.ppat.1009377

  • Mori, Giorgia and Pasca, Maria Rosalia (2021). Gut microbial signatures in sporadic and hereditary colorectal cancer. International Journal of Molecular Sciences, 22 (3) 1312, 1-21. doi: 10.3390/ijms22031312

  • Azzali, Elisa, Girardini, Miriam, Annunziato, Giannamaria, Pavone, Marialaura, Vacondio, Federica, Mori, Giorgia, Pasca, Maria Rosalia, Costantino, Gabriele and Pieroni, Marco (2020). 2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry. ACS Medicinal Chemistry Letters, 11 (7), 1435-1441. doi: 10.1021/acsmedchemlett.0c00173

  • Mori, Giorgia, Orena, Beatrice Silvia, Chiarelli, Laurent R., Degiacomi, Giulia, Riabova, Olga, Sammartino, José Camilla, Makarov, Vadim, Riccardi, Giovanna and Pasca, Maria Rosalia (2020). Rv0579 is involved in the resistance to the TP053 antitubercular prodrug. Frontiers in Microbiology, 11 292, 292. doi: 10.3389/fmicb.2020.00292

  • Chiarelli, Laurent R., Salina, Elena G., Mori, Giorgia, Azhikina, Tatyana, Riabova, Olga, Lepioshkin, Alexander, Grigorov, Artem, Forbak, Martin, Madacki, Jan, Orena, Beatrice Silvia, Manfredi, Marcello, Gosetti, Fabio, Buzzi, Arianna, Degiacomi, Giulia, Sammartino, José Camilla, Marengo, Emilio, Korduláková, Jana, Riccardi, Giovanna, MikuĊĦová, Katarína, Makarov, Vadim and Pasca, Maria Rosalia (2019). New insights into the mechanism of action of the thienopyrimidine antitubercular prodrug TP053. ACS Infectious Diseases, 6 (2) acsinfecdis.9b00388, 313-323. doi: 10.1021/acsinfecdis.9b00388

  • Mori, Giorgia, Orena, Beatrice Silvia, Cultrera, Ilenia, Barbieri, Giulia, Albertini, Alessandra M., Ranzani, Guglielmina Nadia, Carnevali, Ileana, Tibiletti, Maria Grazia and Pasca, Maria Rosalia (2019). Gut microbiota analysis in postoperative Lynch syndrome patients. Frontiers in Microbiology, 10 (JULY) 1746. doi: 10.3389/fmicb.2019.01746

  • Mori, Giorgia, Orena, Beatrice Silvia, Franch, Clara, Mitchenall, Lesley A., Godbole, Adwait Anand, Rodrigues, Liliana, Aguilar-Perez, Clara, Zemanova, Julia, Huszar, Stanislav, Forbak, Martin, Lane, Thomas R., Sabbah, Mohamad, Deboosere, Nathalie, Frita, Rosangela, Vandeputte, Alexandre, Hoffmann, Eik, Russo, Riccardo, Connel, Nancy, Veilleux, Courtney, Jha, Rajiv K., Kumar, Pradeep, Freundlich, Joel S., Brodin, Priscille, Ainsa, Jose Antonio, Nagaraja, Valakunja, Maxwell, Anthony, Mikusova, Katarina, Pasca, Maria Rosalia and Ekins, Sean (2018). The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase. Tuberculosis, 112, 98-109. doi: 10.1016/j.tube.2018.08.004

  • Chiarelli, Laurent R., Mori, Matteo, Barlocco, Daniela, Beretta, Giangiacomo, Gelain, Arianna, Pini, Elena, Porcino, Marianna, Mori, Giorgia, Stelitano, Giovanni, Costantino, Luca, Lapillo, Margherita, Bonanni, Davide, Poli, Giulio, Tuccinardi, Tiziano, Villa, Stefania and Meneghetti, Fiorella (2018). Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents. European Journal of Medicinal Chemistry, 155, 754-763. doi: 10.1016/j.ejmech.2018.06.033

  • Mori, Giorgia, Rampelli, Simone, Orena, Beatrice Silvia, Rengucci, Claudia, De Maio, Giulia, Barbieri, Giulia, Passardi, Alessandro, Gardini, Andrea Casadei, Frassineti, Giovanni Luca, Gaiarsa, Stefano, Albertini, Alessandra M., Ranzani, Guglielmina Nadia, Calistri, Daniele and Pasca, Maria Rosalia (2018). Shifts of faecal microbiota during sporadic colorectal carcinogenesis. Scientific Reports, 8 (1) 10329. doi: 10.1038/s41598-018-28671-9

  • Chiarelli, Laurent R., Mori, Giorgia, Orena, Beatrice Silvia, Esposito, Marta, Lane, Thomas, de Jesus Lopes Ribeiro, Ana Luisa, Degiacomi, Giulia, Zemanova, Julia, Szadocka, Sara, Huszar, Stanislav, Palcekova, Zuzana, Manfredi, Marcello, Gosetti, Fabio, Lelievre, Joel, Ballell, Lluis, Kazakova, Elena, Makarov, Vadim, Marengo, Emilio, Mikusova, Katarina, Cole, Stewart T., Riccardi, Giovanna, Ekins, Sean and Pasca, Maria Rosalia (2018). A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK. Scientific Reports, 8 (1) 3187. doi: 10.1038/s41598-018-21614-4

  • Moulkrere, Bachar Rebat, Orena, Beatrice S., Mori, Giorgia, Saffon-Merceron, Nathalie, Rodriguez, Frederic, Lherbet, Christian, Belkheiri, Nadji, Amari, Mohamed, Hoffmann, Pascal and Fodili, Mokhtar (2018). Evaluation of heteroatom-rich derivatives as antitubercular agents with InhA inhibition properties. Medicinal Chemistry Research, 27 (1), 308-320. doi: 10.1007/s00044-017-2064-x

  • Oliveira, Paulo F. M., Guidetti, Brigitte, Chamayou, Alain, Andre-Barres, Christiane, Madacki, Jan, Kordulakova, Jana, Mori, Giorgia, Orena, Beatrice Silvia, Chiarelli, Laurent Roberto, Pasca, Maria Rosalia, Lherbet, Christian, Carayon, Chantal, Massou, Stephane, Baron, Michel and Baltas, Michel (2017). Mechanochemical synthesis and biological evaluation of novel isoniazid derivatives with potent antitubercular activity. Molecules, 22 (9) 1457, 1457. doi: 10.3390/molecules22091457

  • Esposito, Marta, Szadocka, Sara, Degiacomi, Giulia, Orena, Beatrice S., Mori, Giorgia, Piano, Valentina, Boldrin, Francesca, Zemanova, Julia, Huszar, Stanislav, Barros, David, Ekins, Sean, Lelievre, Joel, Manganelli, Riccardo, Mattevi, Andrea, Pasca, Maria Rosalia, Riccardi, Giovanna, Ballel, Lluis, Mikusova, Katarina and Chiarelli, Laurent R. (2017). A phenotypic based target screening approach delivers new antitubercular CTP synthetase inhibitors. Acs Infectious Diseases, 3 (6), 428-437. doi: 10.1021/acsinfecdis.7b00006

  • Mori, Giorgia, Chiarelli, Laurent Roberto, Riccardi, Giovanna and Pasca, Maria Rosalia (2017). New prodrugs against tuberculosis. Drug Discovery Today, 22 (3), 519-525. doi: 10.1016/j.drudis.2016.09.006

  • Matviiuk, Tetiana, Madacki, Jan, Mori, Giorgia, Orena, Beatrice Silvia, Menendez, Christophe, Kysil, Andrii, Andre-Barres, Christiane, Rodriguez, Frederic, Kordulakova, Jana, Mallet-Ladeira, Sonia, Voitenko, Zoia, Pasca, Maria Rosalia, Lherbet, Christian and Baltas, Michel (2016). Pyrrolidinone and pyrrolidine derivatives: Evaluation as inhibitors of InhA and Mycobacterium tuberculosis. European Journal of Medicinal Chemistry, 123, 462-475. doi: 10.1016/j.ejmech.2016.07.028

  • Chollet, Aurelien, Stigliani, Jean-Luc, Pasca, Maria Rosalia, Mori, Giorgia, Lherbet, Christian, Constant, Patricia, Quemard, Annaik, Bernadou, Jean, Pratviel, Genevieve and Bernardes-Genisson, Vania (2016). Evaluation of the inhibitory activity of (aza)isoindolinone-type compounds: toward in vitro InhA action, Mycobacterium tuberculosis growth and mycolic acid biosynthesis. Chemical Biology and Drug Design, 88 (5), 740-755. doi: 10.1111/cbdd.12804

  • Veau, Damien, Krykun, Serhii, Mori, Giorgia, Orena, Beatrice S., Pasca, Maria R., Frongia, Celine, Lobjois, Valerie, Chassaing, Stefan, Lherbet, Christian and Baltas, Michel (2016). Triazolophthalazines: Easily accessible compounds with potent antitubercular activity. ChemMedChem, 11 (10), 1078-1089. doi: 10.1002/cmdc.201600085

  • Tiwari, Rohit, Miller, Patricia A., Chiarelli, Laurent R., Mori, Giorgia, Sarkan, Michal, Centarova, Ivana, Cho, Sanghyun, Mikusova, Katarina, Franzblau, Scott G., Oliver, Allen G. and Miller, Marvin J. (2016). Design, syntheses, and anti-TB activity of 1,3-benzothiazinone azide and click chemistry products inspired by BTZ043. Acs Medicinal Chemistry Letters, 7 (3), 266-270. doi: 10.1021/acsmedchemlett.5b00424

  • Laborde, Julie, Deraeve, Celine, Lecoq, Lea, Sournia-Saquet, Alix, Stigliani, Jean-Luc, Orena, Beatrice S., Mori, Giorgia, Pratviel, Genevieve and Bernardes-Genisson, Vania (2016). Synthesis, oxidation potential and anti-mycobacterial activity of isoniazid and analogues: insights into the molecular isoniazid activation mechanism. ChemistrySelect, 1 (2), 172-179. doi: 10.1002/slct.201600040

  • Chiarelli, Laurent Roberto, Mori, Giorgia, Esposito, Marta, Orena, Beatrice Silvia and Pasca, Maria Rosalia (2016). New and old hot drug targets in tuberculosis. Current Medicinal Chemistry, 23 (33), 3813-3846. doi: 10.2174/1389557516666160831164925

  • Chollet, Aurelien, Mori, Giorgia, Menendez, Christophe, Rodriguez, Frederic, Fabing, Isabelle, Pasca, Maria Rosalia, Madacki, Jan, Kordulakova, Jana, Constant, Patricia, Quemard, Annaik, Bernardes-Genisson, Vania, Lherbet, Christian and Baltas, Michel (2015). Design, synthesis and evaluation of new GEQ derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth. European Journal of Medicinal Chemistry, 101, 218-235. doi: 10.1016/j.ejmech.2015.06.035

  • Mori, Giorgia, Chiarelli, Laurent R., Esposito, Marta, Makarov, Vadim, Bellinzoni, Marco, Hartkoorn, Ruben C., Degiacomi, Giulia, Boldrin, Francesca, Ekins, Sean, Lopes Ribeiro, Ana Luisa de Jesus, Marino, Leonardo B., Centarova, Ivana, Svetlikova, Zuzana, Blasko, Jaroslav, Kazakova, Elena, Lepioshkin, Alexander, Barilone, Nathalie, Zanoni, Giuseppe, Porta, Alessio, Fondi, Marco, Fani, Renato, Baulard, Alain R., Mikusova, Katarina, Alzari, Pedro M., Manganelli, Riccardo, de Carvalho, Luiz Pedro S., Riccardi, Giovanna, Cole, Stewart T. and Pasca, Maria Rosalia (2015). Thiophenecarboxamide derivatives activated by EthA kill Mycobacterium tuberculosis by inhibiting the CTP synthetase PyrG. Chemistry & Biology, 22 (7) 3069, 917-927. doi: 10.1016/j.chembiol.2015.05.016

  • Perdigao, Gildas, Deraeve, Celine, Mori, Giorgia, Pasca, Maria Rosalia, Pratviel, Genevieve and Bernardes-Genisson, Vania (2015). Pyridine-3,4-dicarboximide as starting material for the total synthesis of the natural product eupolauramine and its isomer iso-eupolauramine endowed with anti-tubercular activities. Tetrahedron, 71 (10), 1555-1559. doi: 10.1016/j.tet.2015.01.034

  • Neres, Joao, Hartkoorn, Ruben C., Chiarelli, Laurent R., Gadupudi, Ramakrishna, Pasca, Maria Rosalia, Mori, Giorgia, Venturelli, Alberto, Savina, Svetlana, Makarov, Vadim, Kolly, Gaelle S., Molteni, Elisabetta, Binda, Claudia, Dhar, Neeraj, Ferrari, Stefania, Brodin, Priscille, Delorme, Vincent, Landry, Valerie, Lopes Ribeiro, Ana Luisa de Jesus, Farina, Davide, Saxena, Puneet, Pojer, Florence, Carta, Antonio, Luciani, Rosaria, Porta, Alessio, Zanoni, Giuseppe, De Rossi, Edda, Costi, Maria Paola, Riccardi, Giovanna and Cole, Stewart T. (2015). 2-carboxyquinoxalines kill Mycobacterium tuberculosis through noncovalent inhibition of DprE1. Acs Chemical Biology, 10 (3), 705-714. doi: 10.1021/cb5007163

  • Albesa-Jove, David, Chiarelli, Laurent R., Makarov, Vadim, Pasca, Maria Rosalia, Urresti, Saioa, Mori, Giorgia, Salina, Elena, Vocat, Anthony, Comino, Natalia, Mohorko, Elisabeth, Ryabova, Svetlana, Pfieiffer, Bernhard, Lopes Ribeiro, Ana Luisa de Jesus, Rodrigo-Unzueta, Ane, Tersa, Montse, Zanoni, Giuseppe, Buroni, Silvia, Altmann, Karl-Heinz, Hartkoorn, Ruben C., Glockshuber, Rudi, Cole, Stewart T., Riccardi, Giovanna and Guerin, Marcelo E. (2014). Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis. Acs Chemical Biology, 9 (7), 1567-1575. doi: 10.1021/cb500149m

  • Matviiuk, Tetiana, Mori, Giorgia, Lherbet, Christian, Rodriguez, Frederic, Pasca, Maria Rosalia, Gorichko, Marian, Guidetti, Brigitte, Voitenko, Zoia and Baltas, Michel (2014). Synthesis of 3-heteryl substituted pyrrolidine-2,5-diones via catalytic Michael reaction and evaluation of their inhibitory activity against InhA and Mycobacterium tuberculosis. European Journal of Medicinal Chemistry, 71, 46-52. doi: 10.1016/j.ejmech.2013.10.069

  • Incandela, Maria Loreto, Perrin, Elena, Fondi, Marco, Ribeiro, Ana Luisa de Jesus Lopes, Mori, Giorgia, Moiana, Alessia, Gramegna, Maurizio, Fani, Renato, Riccardi, Giovanna and Pasca, Maria Rosalia (2013). DprE1, a new taxonomic marker in mycobacteria. Fems Microbiology Letters, 348 (1), 66-73. doi: 10.1111/1574-6968.12246

  • Ribeiro, Ana Luisa de Jesus Lopes, Degiacomi, Giulia, Ewann, Fanny, Buroni, Silvia, Incandela, Maria Loreto, Chiarelli, Laurent R., Mori, Giorgia, Kim, Jaeseung, Contreras-Dominguez, Monica, Park, Young-Sam, Han, Sung-Jun, Brodin, Priscille, Valentini, Giovanna, Rizzi, Menico, Riccardi, Giovanna and Pasca, Maria Rosalia (2011). Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis. PLoS One, 6 (11) e26675. doi: 10.1371/journal.pone.0026675