Journal Article: A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration
San Gil, Rebecca, Pascovici, Dana, Venturato, Juliana, Brown-Wright, Heledd, Mehta, Prachi, Madrid San Martin, Lidia, Wu, Jemma, Luan, Wei, Chui, Yi Kit, Bademosi, Adekunle T., Swaminathan, Shilpa, Naidoo, Serey, Berning, Britt A., Wright, Amanda L., Keating, Sean S., Curtis, Maurice A., Faull, Richard L. M., Lee, John D., Ngo, Shyuan T., Lee, Albert, Morsch, Marco, Chung, Roger S., Scotter, Emma, Lisowski, Leszek, Mirzaei, Mehdi and Walker, Adam K. (2024). A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nature Communications, 15 (1) 1508, 1508. doi: 10.1038/s41467-024-45646-9
Journal Article: Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD
Luan, Wei, Wright, Amanda L., Brown-Wright, Heledd, Le, Sheng, San Gil, Rebecca, Madrid San Martin, Lidia, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank and Walker, Adam K. (2023). Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD. Molecular Psychiatry, 28 (6), 2445-2461. doi: 10.1038/s41380-023-02036-9
Journal Article: The GLP-1 receptor agonist, liraglutide, fails to slow disease progression in SOD1G93A and TDP-43Q331K transgenic mouse models of ALS
Keerie, Amy, Brown-Wright, Heledd, Kirkland, Isaac, Grierson, Andrew, Alix, James J. P., Holscher, Christian and Mead, Richard J. (2021). The GLP-1 receptor agonist, liraglutide, fails to slow disease progression in SOD1G93A and TDP-43Q331K transgenic mouse models of ALS. Scientific Reports, 11 (1) 17027, 1-10. doi: 10.1038/s41598-021-96418-0
New viral-mediated TDP-43 mouse models of MND
(2022–2024) Cure for MND Foundation - Impact Grants
New mouse models of TDP-43 pathology
(2020–2021) Motor Neurone Disease Research Institute of Australia Inc
San Gil, Rebecca, Pascovici, Dana, Venturato, Juliana, Brown-Wright, Heledd, Mehta, Prachi, Madrid San Martin, Lidia, Wu, Jemma, Luan, Wei, Chui, Yi Kit, Bademosi, Adekunle T., Swaminathan, Shilpa, Naidoo, Serey, Berning, Britt A., Wright, Amanda L., Keating, Sean S., Curtis, Maurice A., Faull, Richard L. M., Lee, John D., Ngo, Shyuan T., Lee, Albert, Morsch, Marco, Chung, Roger S., Scotter, Emma, Lisowski, Leszek, Mirzaei, Mehdi and Walker, Adam K. (2024). A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nature Communications, 15 (1) 1508, 1508. doi: 10.1038/s41467-024-45646-9
Luan, Wei, Wright, Amanda L., Brown-Wright, Heledd, Le, Sheng, San Gil, Rebecca, Madrid San Martin, Lidia, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank and Walker, Adam K. (2023). Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD. Molecular Psychiatry, 28 (6), 2445-2461. doi: 10.1038/s41380-023-02036-9
Keerie, Amy, Brown-Wright, Heledd, Kirkland, Isaac, Grierson, Andrew, Alix, James J. P., Holscher, Christian and Mead, Richard J. (2021). The GLP-1 receptor agonist, liraglutide, fails to slow disease progression in SOD1G93A and TDP-43Q331K transgenic mouse models of ALS. Scientific Reports, 11 (1) 17027, 1-10. doi: 10.1038/s41598-021-96418-0
Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss
White, Matthew A., Lin, Ziqiang, Kim, Eugene, Henstridge, Christopher M., Altamira, Emiliano Pena, Hunt, Camille K., Burchill, Ella, Callaghan, Isobel, Loreto, Andrea, Brown-Wright, Heledd, Mead, Richard, Simmons, Camilla, Cash, Diana, Coleman, Michael P. and Sreedharan, Jemeen (2019). Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss. Acta Neuropathologica Communications, 7 (1) 166, 1-16. doi: 10.1186/s40478-019-0800-9
Beer, Alexander M., Cooper-Knock, Johnathan, Fletcher, Sakina, Brown-Wright, Sian Heledd, Nandakumar, T. Pisharam and Shaw, Pamela J. (2016). Case report of concurrent Fabry disease and amyotrophic lateral sclerosis supports a common pathway of pathogenesis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 17 (7-8), 614-616. doi: 10.3109/21678421.2016.1170150
New viral-mediated TDP-43 mouse models of MND
(2022–2024) Cure for MND Foundation - Impact Grants
New mouse models of TDP-43 pathology
(2020–2021) Motor Neurone Disease Research Institute of Australia Inc