The University of Queensland

Probing the biocompatibility and immune cell association of chiral, water-soluble, bottlebrush poly(2-oxazoline)s

Pizzi, David, Humphries, James, Morrow, Joshua P., Mahmoud, Ayaat M., Fletcher, Nicholas L., Sonderegger, Stefan E., Bell, Craig A., Thurecht, Kristofer J. and Kempe, Kristian (2022). Probing the biocompatibility and immune cell association of chiral, water-soluble, bottlebrush poly(2-oxazoline)s. Biomacromolecules, 24 (1), 246-257. doi: 10.1021/acs.biomac.2c01105

Modulating macrophage clearance of nanoparticles: comparison of small-molecule and biologic drugs as pharmacokinetic modifiers of soft nanomaterials

Mills, Jessica A., Humphries, James, Simpson, Joshua D., Sonderegger, Stefan E., Thurecht, Kristofer J. and Fletcher, Nicholas L. (2022). Modulating macrophage clearance of nanoparticles: comparison of small-molecule and biologic drugs as pharmacokinetic modifiers of soft nanomaterials. Molecular Pharmaceutics, 19 (11), 4080-4097. doi: 10.1021/acs.molpharmaceut.2c00528

Author Correction: Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells (Nature Communications, (2020), 11, 1, (6211), 10.1038/s41467-020-20091-6)

Tremblay, Cedric S., Chiu, Sung Kai, Saw, Jesslyn, McCalmont, Hannah, Litalien, Veronique, Boyle, Jacqueline, Sonderegger, Stefan E., Chau, Ngoc, Evans, Kathryn, Cerruti, Loretta, Salmon, Jessica M., McCluskey, Adam, Lock, Richard B., Robinson, Phillip J., Jane, Stephen M. and Curtis, David J. (2021). Author Correction: Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells (Nature Communications, (2020), 11, 1, (6211), 10.1038/s41467-020-20091-6). Nature Communications, 12 (1) 1288. doi: 10.1038/s41467-021-21688-1

Fluorophore selection and incorporation contribute to permeation and distribution behaviors of hyperbranched polymers in multi-cellular tumor spheroids and xenograft tumor models

Simpson, Joshua D., Monteiro, Patrícia F., Ediriweera, Gayathri R., Prior, Amber R., Sonderegger, Stefan E., Bell, Craig A., Fletcher, Nicholas L., Alexander, Cameron and Thurecht, Kristofer J. (2021). Fluorophore selection and incorporation contribute to permeation and distribution behaviors of hyperbranched polymers in multi-cellular tumor spheroids and xenograft tumor models. ACS Applied Bio Materials, 4 (3) acsabm.0c01616, 2675-2685. doi: 10.1021/acsabm.0c01616

An immunoregulatory role for complement receptors in murine models of breast cancer

Akhir, Fazrena Nadia Md, Noor, Mohd Hezmee Mohd, Leong, Keith Weng Kit, Nabizadeh, Jamileh A., Manthey, Helga D., Sonderegger, Stefan E., Fung, Jenny Nga Ting, McGirr, Crystal E., Shiels, Ian A., Mills, Paul C., Woodruff, Trent M. and Rolfe, Barbara E. (2021). An immunoregulatory role for complement receptors in murine models of breast cancer. Antibodies, 10 (1) 2, 1-12. doi: 10.3390/antib10010002

Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells

Tremblay, Cedric S., Chiu, Sung Kai, Saw, Jesslyn, McCalmont, Hannah, Litalien, Veronique, Boyle, Jacqueline, Sonderegger, Stefan E., Chau, Ngoc, Evans, Kathryn, Cerruti, Loretta, Salmon, Jessica M., McCluskey, Adam, Lock, Richard B., Robinson, Phillip J., Jane, Stephen M. and Curtis, David J. (2020). Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells. Nature Communications, 11 (1) 6211. doi: 10.1038/s41467-020-20091-6

Controlling the biological fate of micellar nanoparticles: balancing stealth and targeting

Sivaram, Amal J., Wardiana, Andri, Alcantara, Sheilajen, Sonderegger, Stefan E., Fletcher, Nicholas L., Houston, Zachary H., Howard, Christopher B., Mahler, Stephen M., Alexander, Cameron, Kent, Stephen J., Bell, Craig A. and Thurecht, Kristofer J. (2020). Controlling the biological fate of micellar nanoparticles: balancing stealth and targeting. ACS Nano, 14 (10) acsnano.0c06033, 13739-13753. doi: 10.1021/acsnano.0c06033

Hyperbranched Poly(2-oxazoline)s and Poly(ethylene glycol): A structure–activity comparison of biodistribution

Humphries, James, Pizzi, David, Sonderegger, Stefan E., Fletcher, Nicholas L., Houston, Zachary H., Bell, Craig A., Kempe, Kristian and Thurecht, Kristofer J. (2020). Hyperbranched Poly(2-oxazoline)s and Poly(ethylene glycol): A structure–activity comparison of biodistribution. Biomacromolecules, 21 (8) acs.biomac.0c00765, 3318-3331. doi: 10.1021/acs.biomac.0c00765

Attenuated acceleration to leukemia after Ezh2 loss in Nup98-HoxD13 (NHD13) myelodysplastic syndrome

Ling, Victoria Y., Saw, Jesslyn, Tremblay, Cedric S., Sonderegger, Stefan E., Toulmin, Emma, Boyle, Jacqueline, Chiu, Sung Kai, Lane, Steven W., Ting, Stephen B. and Curtis, David J. (2019). Attenuated acceleration to leukemia after Ezh2 loss in Nup98-HoxD13 (NHD13) myelodysplastic syndrome. HemaSphere, 3 (4) e277, e277. doi: 10.1097/HS9.0000000000000277

Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

Tremblay, Cedric S., Saw, Jesslyn, Chiu, Sung Kai, Wong, Nicholas C., Tsyganov, Kirill, Ghotb, Sarah, Graham, Alison N., Yan, Feng, Guirguis, Andrew A., Sonderegger, Stefan E., Lee, Nicole, Kalitsis, Paul, Reynolds, John, Ting, Stephen B., Powell, David R., Jane, Stephen M. and Curtis, David J. (2018). Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells. Nature Communications, 9 (1) 3535. doi: 10.1038/s41467-018-06021-7

A novel role for Lyl1 in primitive erythropoiesis

Chiu, Sung K., Saw, Jesslyn, Huang, Yizhou, Sonderegger, Stefan E., Wong, Nicholas C., Powell, David R., Beck, Dominic, Pimanda, John E., Tremblay, Cedric S. and Curtis, David J. (2018). A novel role for Lyl1 in primitive erythropoiesis. Development, 145 (19), 1-9. doi: 10.1242/dev.162990

Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Goossens, Steven, Peirs, Sofie, Van Loocke, Wouter, Wang, Jueqiong, Takawy, Mina, Matthijssens, Filip, Sonderegger, Stefan E., Haigh, Katharina, Thao Nguyen,, Vandamme, Niels, Costa, Magdaline, Carmichael, Catherine, Van Nieuwerburgh, Filip, Deforce, Dieter, Kleifeld, Oded, Curtis, David J., Berx, Geert, Van Vlierberghe, Pieter and Haigh, Jody J. (2017). Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia. Blood, 129 (8), 981-990. doi: 10.1182/blood-2016-06-721191

Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling

Tremblay, C. S., Brown, F. C., Collett, M., Saw, J., Chiu, S. K., Sonderegger, S. E., Lucas, S. E., Alserihi, R., Chau, N., Toribio, M. L., McCormack, M. P., Chircop, M., Robinson, P. J., Jane, S. M. and Curtis, D. J. (2016). Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling. Leukemia, 30 (10), 1993-2001. doi: 10.1038/leu.2016.100

The role of leukemia inhibitory factor in tubal ectopic pregnancy

Krishnan, T., Winship, A., Sonderegger, S., Menkhorst, E., Horne, A. W., Brown, J., Zhang, J. -G., Nicola, N. A., Tong, S. and Dimitriadis, E. (2013). The role of leukemia inhibitory factor in tubal ectopic pregnancy. Placenta, 34 (11), 1014-1019. doi: 10.1016/j.placenta.2013.09.003

AKT isoforms 1 and 3 regulate basal and epidermal growth factor-stimulated SGHPL-5 trophoblast cell migration in humans

Haslinger, Peter, Haider, Sandra, Sonderegger, Stefan, Otten, Jan Velten, Pollheimer, Juergen, Whitley, Guy and Knoefler, Martin (2013). AKT isoforms 1 and 3 regulate basal and epidermal growth factor-stimulated SGHPL-5 trophoblast cell migration in humans. Biology of Reproduction, 88 (3) 54. doi: 10.1095/biolreprod.112.104778

Wnt1 is anti-lymphangiogenic in a melanoma mouse model

Niederleithner, Heide, Heinz, Magdalena, Tauber, Stefanie, Bilban, Martin, Pehamberger, Hubert, Sonderegger, Stefan, Knoefler, Martin, Bracher, Andreas, Berger, Walter, Loewe, Robert and Petzelbauer, Peter (2012). Wnt1 is anti-lymphangiogenic in a melanoma mouse model. Journal of Investigative Dermatology, 132 (9), 2235-2244. doi: 10.1038/jid.2012.138

Interleukin 11 regulates endometrial cancer cell adhesion and migration via STAT3

Lay, Virginia, Yap, Joanne, Sonderegger, Stefan and Dimitriadis, Evdokia (2012). Interleukin 11 regulates endometrial cancer cell adhesion and migration via STAT3. International Journal of Oncology, 41 (2), 759-764. doi: 10.3892/ijo.2012.1486

Interleukin (IL)11 mediates protein secretion and modification in human extravillous trophoblasts

Sonderegger, Stefan, Yap, Joanne, Menkhorst, Ellen, Weston, Gareth, Stanton, Peter G. and Dimitriadis, Evdokia (2011). Interleukin (IL)11 mediates protein secretion and modification in human extravillous trophoblasts. Human Reproduction, 26 (10), 2841-2849. doi: 10.1093/humrep/der259

Transcription factor AP-2α promotes EGF-dependent invasion of human trophoblast

Biadasiewicz, Katarzyna, Sonderegger, Stefan, Haslinger, Peter, Haider, Sandra, Saleh, Leila, Fiala, Christian, Pollheimer, Jürgen and Knöfler, Martin (2011). Transcription factor AP-2α promotes EGF-dependent invasion of human trophoblast. Endocrinology, 152 (4), 1458-1469. doi: 10.1210/en.2010-0936

Wnt signalling in implantation, decidualisation and placental differentiation - review

Sonderegger, S., Pollheimer, J. and Knoefler, M. (2010). Wnt signalling in implantation, decidualisation and placental differentiation - review. Placenta, 31 (10), 839-847. doi: 10.1016/j.placenta.2010.07.011

Governing the invasive trophoblast: current aspects on intra- and extracellular regulation

Fitzgerald, Justine S., Germeyer, Ariane, Huppertz, Berthold, Jeschke, Udo, Knöfler, Martin, Moser, Gerit, Scholz, Christoph, Sonderegger, Stefan, Toth, Bettina and Markert, Udo R. (2010). Governing the invasive trophoblast: current aspects on intra- and extracellular regulation. American Journal of Reproductive Immunology, 63 (6), 492-505. doi: 10.1111/j.1600-0897.2010.00824.x

Wingless (Wnt)-3A Induces Trophoblast Migration and Matrix Metalloproteinase-2 Secretion through Canonical Wnt Signaling and Protein Kinase B/AKT Activation

Sonderegger, Stefan, Haslinger, Peter, Sabri, Alia, Leisser, Christina, Otten, Jan V., Fiala, Christian and Knoefler, Martin (2010). Wingless (Wnt)-3A Induces Trophoblast Migration and Matrix Metalloproteinase-2 Secretion through Canonical Wnt Signaling and Protein Kinase B/AKT Activation. Endocrinology, 151 (1), 211-220. doi: 10.1210/en.2009-0557

Expression, Regulation and Functional Characterization of Matrix Metalloproteinase-3 of Human Trophoblast

Husslein, H., Haider, S., Meinhardt, G., Prast, J., Sonderegger, S. and Knoefler, M. (2009). Expression, Regulation and Functional Characterization of Matrix Metalloproteinase-3 of Human Trophoblast. Placenta, 30 (3), 284-291. doi: 10.1016/j.placenta.2008.12.002

Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling

Prast, Johanna, Saleh, Leila, Husslein, Heinrich, Sonderegger, Stefan, Helmer, Hanns and Knöfler, Martin (2008). Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling. Endocrinology, 149 (3), 979-987. doi: 10.1210/en.2007-1282

Tumour necrosis factor-α impairs chorionic gonadotrophin β-subunit expression and cell fusion of human villous cytotrophoblast

Leisser, C., Saleh, L., Haider, S., Husslein, H., Sonderegger, S. and Knöfler, Martin (2006). Tumour necrosis factor-α impairs chorionic gonadotrophin β-subunit expression and cell fusion of human villous cytotrophoblast. Molecular Human Reproduction, 12 (10), 601-609. doi: 10.1093/molehr/gal066

Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast

Pollheimer, J., Loregger, T., Sonderegger, S., Saleh, L., Bauer, S., Bilban, M., Czerwenka, K., Husslein, P. and Knofler, M. (2006). Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast. American Journal of Pathology, 168 (4), 1134-1147. doi: 10.2353/ajpath.2006.050686

DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells

Eger, Andreas, Aigner, Kirsten, Sonderegger, Stefan, Dampier, Brigatta, Oehler, Susanne, Schreiber, Martin, Berx, Geert, Cano, Amparo, Beug, Hartmut and Foisner, Roland (2005). DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene, 24 (14), 2375-2385. doi: 10.1038/sj.onc.1208429

Immunoregulatory role for complement receptors in murine breast cancer

Rolfe, Barbara, Sonderegger, Stefan, McGirr, Crystal and Woodruff, Trent (2022). Immunoregulatory role for complement receptors in murine breast cancer. 28th Virtual International Complement Workshop (ICW) of the International-Complement-Society (ICS), Virtual, 6-10 December 2021. Oxford, United Kingdom: Elsevier.

DYNAMIN-DEPENDENT ENDOCYTOSIS IS REQUIRED FOR MULTIPLE NICHE SIGNALS THAT ARE CRUCIAL FOR LEUKEMIA STEM CELL ACTIVITY AND CHEMORESISTANCE

Tremblay, Cedric, Chiu, Sung, Saw, Jesslyn, Sonderegger, Stefan, Chau, Ngoc, McCluskey, Adam, Robinson, Phillip, Jane, Stephen and Curtis, David (2019). DYNAMIN-DEPENDENT ENDOCYTOSIS IS REQUIRED FOR MULTIPLE NICHE SIGNALS THAT ARE CRUCIAL FOR LEUKEMIA STEM CELL ACTIVITY AND CHEMORESISTANCE. NEW YORK: ELSEVIER SCIENCE INC.

PRMT5 Inhibition Selectively Targets Acute Myeloid Leukemia Stem Cells Though a p53-Dependent Mechanism

Toulmin, Emma, Sonderegger, Stefan, Cerruti, Loretta, Terzic, Andrej, Yan, Feng, Wong, Nicholas, Street, Ian, Stupple, Paul, Jane, Stephen, Wei, Andrew H., Altura, Rachel, Nicholson, Benjamin and Curtis, David J. (2018). PRMT5 Inhibition Selectively Targets Acute Myeloid Leukemia Stem Cells Though a p53-Dependent Mechanism. 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego Ca, Dec 01-04, 2018. WASHINGTON: AMER SOC HEMATOLOGY. doi: 10.1182/blood-2018-99-117835

Small-Molecule Inhibition of PRMT5 Induces Translational Stress and p53 in JAK2V617F Mutant Myeloproliferative Neoplasms

Sonderegger, Stefan, Cerruti, Loretta, Tremblay, Cedric, Toulmin, Emma, Saw, Jesslyn, Nebl, Tom, Hannan, Katherine M., Lane, Steven W., Falk, Hendrik, Unnikrishnan, Ashwin, Stupple, Paul, Street, Ian, Jane, Stephen, Altura, Rachel, Nicholson, Benjamin and Curtis, David J. (2018). Small-Molecule Inhibition of PRMT5 Induces Translational Stress and p53 in JAK2V617F Mutant Myeloproliferative Neoplasms. 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego Ca, Dec 01-04, 2018. WASHINGTON: AMER SOC HEMATOLOGY. doi: 10.1182/blood-2018-99-118406

PRMT5 inhibitors as novel treatment for cancers

Falk, Hendrik, Foitzik, Richard C., Allan, Elizabeth, deSilva, Melanie, Yang, Hong, Bozikis, Ylva E., Nikac, Marica, Walker, Scott R., Camerino, Michelle A., Morrow, Ben J., Stupple, Alexandra E., Lagiakos, Rachel, Pinson, Jo-Anne, Lessene, Romina, Kersten, Wilhelmus J. A., Ganame, Danny G., Holmes, Ian P., Lunniss, Gill E., Chung, Matthew, Hermans, Stefan J., Parker, Michael W., Thistlethwaite, Alison, White, Karen, Charman, Susan A., Monahan, Brendon J., Pilling, Patricia, Grusovin, Julian, Peat, Thomas S., Sonderegger, Stefan ... Street, Ian P. (2015). PRMT5 inhibitors as novel treatment for cancers. 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Philadelphia Pa, Apr 18-22, 2015. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.AM2015-5371

Selective Inhibitors of Arginine Methyl Transferase 5 (PRMT5) As a Novel Treatment for beta-Thalassemia and Sickle Cell Disease

Street, Ian, Monahan, Brendon, Falk, Hendrik, Allan, Elizabeth, Bergman, Ylva, Stupple, Paul, Holmes, Ian, Gregg, Alison, Charman, Susan, Lackovic, Kurt, Peat, Tom, Walker, Scott, Lowes, Kym, Kersten, Wilco, Alcindor, Jo, Chung, Matthew, Parker, Michael, Foitzik, Richard, Camerino, Michelle, Nikac, Marcia, Grusovin, Julian, Pilling, Pat, Sonderegger, Stefan, Tan, Yuen, Zhao, Quan, Curtis, David J. and Jane, Stephen M. (2012). Selective Inhibitors of Arginine Methyl Transferase 5 (PRMT5) As a Novel Treatment for beta-Thalassemia and Sickle Cell Disease. 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta Ga, Dec 08-11, 2012. WASHINGTON: AMER SOC HEMATOLOGY.

Expression pattern and functional analyses of Akt isoforms in human trophoblasts

Haslinger, P., Otten, J., Sonderegger, S. and Knofler, M. (2008). Expression pattern and functional analyses of Akt isoforms in human trophoblasts. 14th Meeting of the International-Federation-of-Placental-Associations/12th Meeting of the European-Placenta-Group (IFPA/EPG), Seggau Castle Austria, Sep 10-13, 2008. LONDON: W B SAUNDERS CO LTD.

The role of matrix metalloproteinase-3 in human trophoblast invasion

Prast, Johanna, Husslein, Heinrich, Haider, Sandra, Meinhardt, Gudrun, Sonderegger, Stefan and Knoefler, Martin (2008). The role of matrix metalloproteinase-3 in human trophoblast invasion. 14th Meeting of the International-Federation-of-Placental-Associations/12th Meeting of the European-Placenta-Group (IFPA/EPG), Seggau Castle Austria, Sep 10-13, 2008. LONDON: W B SAUNDERS CO LTD.

WNT-induced trophoblast migration involves DKK-1-and AKT-dependent expression of MMP-2

Sonderegger, S., Haslinger, P., Leisser, C., Sabri, A., Otten, J. and Knoefler, M. (2008). WNT-induced trophoblast migration involves DKK-1-and AKT-dependent expression of MMP-2. 14th Meeting of the International-Federation-of-Placental-Associations/12th Meeting of the European-Placenta-Group (IFPA/EPG), Seggau Castle Austria, Sep 10-13, 2008. LONDON: W B SAUNDERS CO LTD.

Human chorionic gonadotrophin promotes trophoblast migration and invasion through ERK and AKT signaling

Prast, J., Saleh, L., Husslein, H., Sonderegger, S. and Knoefler, M. (2008). Human chorionic gonadotrophin promotes trophoblast migration and invasion through ERK and AKT signaling. 3rd Latin-American Symposium on Maternal-Fetal Interaction and Placenta, Los Cocos Argentina, Nov 04-07, 2007. LONDON: W B SAUNDERS CO LTD.

Human chorionic gonadotrophin promotes trophoblast migration and invasion through ERK and AKT signaling

Prast, J., Saleh, L., Husslem, H., Sonderegger, S. and Knoefler, M. (2007). Human chorionic gonadotrophin promotes trophoblast migration and invasion through ERK and AKT signaling. 13th International-Federation-of-Placenta-Association Meeting, Kingston Canada, Aug 17-22, 2007. LONDON: W B SAUNDERS CO LTD.

Complex expression pattern of Wnt ligands and frizzled receptors in human placenta and its trophoblast subtypes

Sonderegger, S., Husslein, H., Leisser, C. and Knoefler, A. (2007). Complex expression pattern of Wnt ligands and frizzled receptors in human placenta and its trophoblast subtypes. 12th Meeting of the International-Federation-of-Placenta-Association/14th Meeting of the Japan-Plancenta-Association/24th Meeting of Japan Trophoblast Disease Study Group, Kobe, Japan, 6-9 September 2006. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2006.11.003

The role of Wnt-dependent signalling cascades in human trophoblast invasion

Sonderegger, S., Leisser, C., Poltheimer, J., Husslein, H. and Knofler, M. (2006). The role of Wnt-dependent signalling cascades in human trophoblast invasion. 12th Meeting of the International-Federation-of-Placenta-Association, Kobe Japan, Sep 06-09, 2006. LONDON: W B SAUNDERS CO LTD.

Tumour necrosis factor impairs chorionic gonadotrophin beta-subunit expression and cell fusion of human villous cytotrophoblast

Leisser, C., Saleh, L., Haider, S., Husslein, H., Sonderegger, S. and Knofler, M. (2006). Tumour necrosis factor impairs chorionic gonadotrophin beta-subunit expression and cell fusion of human villous cytotrophoblast. 12th Meeting of the International-Federation-of-Placenta-Association, Kobe Japan, Sep 06-09, 2006. LONDON: W B SAUNDERS CO LTD.