The University of Queensland

Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms

Weger, Benjamin D., Gobet, Cédric, David, Fabrice P. A., Atger, Florian, Martin, Eva, Phillips, Nicholas E., Charpagne, Aline, Weger, Meltem, Naef, Felix and Gachon, Frédéric (2021). Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms. Proceedings of the National Academy of Sciences, 118 (3) e2015803118, 1-12. doi: 10.1073/pnas.2015803118

The mouse microbiome is required for sex-specific diurnal rhythms of gene expression and metabolism

Weger, Benjamin D, Gobet, Cédric, Yeung, Jake, Martin, Eva, Jimenez, Sonia, Betrisey, Bertrand, Foata, Francis, Berger, Bernard, Balvay, Aurélie, Foussier, Anne, Charpagne, Aline, Boizet-Bonhoure, Brigitte, Chou, Chieh Jason, Naef, Felix and Gachon, Frédéric (2019). The mouse microbiome is required for sex-specific diurnal rhythms of gene expression and metabolism. Cell Metabolism, 29 (2), 362-382. doi: 10.1016/j.cmet.2018.09.023

Understanding circadian dynamics: current progress and future directions for chronobiology in drug discovery

Weger, Meltem, Weger, Benjamin D. and Gachon, Frédéric (2023). Understanding circadian dynamics: current progress and future directions for chronobiology in drug discovery. Expert Opinion on Drug Discovery, 18 (8), 893-901. doi: 10.1080/17460441.2023.2224554

Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior

Delbès, Anne-Sophie, Quiñones, Mar, Gobet, Cédric, Castel, Julien, Denis, Raphaël G. P., Berthelet, Jérémy, Weger, Benjamin D., Challet, Etienne, Charpagne, Aline, Metairon, Sylviane, Piccand, Julie, Kraus, Marine, Rohde, Bettina H., Bial, John, Wilson, Elizabeth M., Vedin, Lise-Lotte, Minniti, Mirko E., Pedrelli, Matteo, Parini, Paolo, Gachon, Frédéric and Luquet, Serge (2023). Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior. Science Advances, 9 (20) eadf2982, 1-14. doi: 10.1126/sciadv.adf2982

Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock

Bignon, Yohan, Wigger, Leonore, Ansermet, Camille, Weger, Benjamin D., Lagarrigue, Sylviane, Centeno, Gabriel, Durussel, Fanny, Götz, Lou, Ibberson, Mark, Pradervand, Sylvain, Quadroni, Manfredo, Weger, Meltem, Amati, Francesca, Gachon, Frédéric and Firsov, Dmitri (2023). Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock. Journal of Clinical Investigation, 133 (8) e167133, 1-17. doi: 10.1172/JCI167133

Comprehensive analysis of the circadian nuclear and cytoplasmic transcriptome in mouse liver

Hurni, Clémence, Weger, Benjamin D., Gobet, Cédric and Naef, Felix (2022). Comprehensive analysis of the circadian nuclear and cytoplasmic transcriptome in mouse liver. PLOS Genetics, 18 (8) e1009903, e1009903. doi: 10.1371/journal.pgen.1009903

Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease

Jouffe, Céline, Weger, Benjamin D., Martin, Eva, Atger, Florian, Weger, Meltem, Gobet, Cédric, Ramnath, Divya, Charpagne, Aline, Morin-Rivron, Delphine, Powell, Elizabeth E., Sweet, Matthew J., Masoodi, Mojgan, Uhlenhaut, N. Henriette and Gachon, Frédéric (2022). Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease. Proceedings of the National Academy of Sciences, 119 (10) e2200083119, e2200083119. doi: 10.1073/pnas.2200083119

The mechanisms and physiological consequences of diurnal hepatic cell size fluctuations: a brief review

Weger, Meltem, Weger, Benjamin D. and Gachon, Frédéric (2022). The mechanisms and physiological consequences of diurnal hepatic cell size fluctuations: a brief review. Cellular Physiology and Biochemistry, 56 (S2), 1-11. doi: 10.33594/000000489

The Insulin/Insulin‐like Growth Factor signaling connects metabolism with sexual differentiation

Weger, Benjamin D. and Gachon, Frédéric (2021). The Insulin/Insulin‐like Growth Factor signaling connects metabolism with sexual differentiation. Acta Physiologica, 231 (3) e13576, e13576. doi: 10.1111/apha.13576

Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms

Weger, Benjamin D., Gobet, Cédric, David, Fabrice P. A., Atger, Florian, Martin, Eva, Phillips, Nicholas E., Charpagne, Aline, Weger, Meltem, Naef, Felix and Gachon, Frédéric (2021). Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms. Proceedings of the National Academy of Sciences, 118 (3) e2015803118, 1-12. doi: 10.1073/pnas.2015803118

Neuronal activity regulates blood-brain barrier efflux transport through endothelial circadian genes

Pulido, Robert S., Munji, Roeben N., Chan, Tamara C., Quirk, Clare R., Weiner, Geoffrey A., Weger, Benjamin D., Rossi, Meghan J., Elmsaouri, Sara, Malfavon, Mario, Deng, Aaron, Profaci, Caterina P., Blanchette, Marie, Qian, Tongcheng, Foreman, Koji L., Shusta, Eric V., Gorman, Michael R., Gachon, Frédéric, Leutgeb, Stefan and Daneman, Richard (2020). Neuronal activity regulates blood-brain barrier efflux transport through endothelial circadian genes. Neuron, 108 (5), 937-952.e7. doi: 10.1016/j.neuron.2020.09.002

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

Weger, Meltem, Weger, Benjamin D, Schink, Andrea, Takamiya, Masanari, Stegmaier, Johannes, Gobet, Cédric, Parisi, Alice, Kobitski, Andrei Yu, Mertes, Jonas, Krone, Nils, Strähle, Uwe, Nienhaus, Gerd Ulrich, Mikut, Ralf, Gachon, Frédéric, Gut, Philipp and Dickmeis, Thomas (2020). MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly. eLife, 9 e57068, 1-35. doi: 10.7554/elife.57068

Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves

Takamiya, Masanari, Stegmaier, Johannes, Kobitski, Andrei Yu, Schott, Benjamin, Weger, Benjamin D., Margariti, Dimitra, Cereceda Delgado, Angel R., Gourain, Victor, Scherr, Tim, Yang, Lixin, Sorge, Sebastian, Otte, Jens C., Hartmann, Volker, van Wezel, Jos, Stotzka, Rainer, Reinhard, Thomas, Schlunck, Günther, Dickmeis, Thomas, Rastegar, Sepand, Mikut, Ralf, Nienhaus, Gerd Ulrich and Strähle, Uwe (2020). Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves. PLoS Genetics , 16 (6) e1008774, e1008774. doi: 10.1371/journal.pgen.1008774

Robust landscapes of ribosome dwell times and aminoacyl-tRNAs in response to nutrient stress in liver

Gobet, Cédric, Weger, Benjamin Dieter, Marquis, Julien, Martin, Eva, Neelagandan, Nagammal, Gachon, Frédéric and Naef, Felix (2020). Robust landscapes of ribosome dwell times and aminoacyl-tRNAs in response to nutrient stress in liver. Proceedings of the National Academy of Sciences, 117 (17), 9630-9641. doi: 10.1073/pnas.1918145117

At the intersection of microbiota and circadian clock: are sexual dimorphism and growth hormones the missing link to pathology? Circadian clock and microbiota: potential egffect on growth hormone and sexual development

Weger, Benjamin D., Rawashdeh, Oliver and Gachon, Frédéric (2019). At the intersection of microbiota and circadian clock: are sexual dimorphism and growth hormones the missing link to pathology? Circadian clock and microbiota: potential egffect on growth hormone and sexual development. BioEssays, 41 (9) 1900059, e1900059. doi: 10.1002/bies.201900059

Circadian regulation of cochlear sensitivity to noise by circulating glucocorticoids

Cederroth, Christopher R., Park, Jung-sub, Basinou, Vasiliki, Weger, Benjamin D., Tserga, Evangelia, Sarlus, Heela, Magnusson, Anna K., Kadri, Nadir, Gachon, Frédéric and Canlon, Barbara (2019). Circadian regulation of cochlear sensitivity to noise by circulating glucocorticoids. Current Biology, 29 (15), 2477-2487.e6. doi: 10.1016/j.cub.2019.06.057

Microbiota and the clock: sexual dimorphism matters!

Weger, Benjamin D and Gachon, Frédéric (2019). Microbiota and the clock: sexual dimorphism matters!. Aging, 11 (12), 3893-3894. doi: 10.18632/aging.102051

Publisher correction: Menstrual cycle rhythmicity: metabolic patterns in healthy women (Scientific Reports, (2018), 8, 1, (14568), 10.1038/s41598-018-32647-0)

Draper, C. F., Duisters, K., Weger, B., Chakrabarti, A., Harms, A. C., Brennan, L., Hankemeier, T., Goulet, L., Konz, T., Martin, F. P., Moco, S. and van der Greef, J. (2019). Publisher correction: Menstrual cycle rhythmicity: metabolic patterns in healthy women (Scientific Reports, (2018), 8, 1, (14568), 10.1038/s41598-018-32647-0). Scientific Reports, 9 (1) 5797, 5797. doi: 10.1038/s41598-019-41392-x

The mouse microbiome is required for sex-specific diurnal rhythms of gene expression and metabolism

Weger, Benjamin D, Gobet, Cédric, Yeung, Jake, Martin, Eva, Jimenez, Sonia, Betrisey, Bertrand, Foata, Francis, Berger, Bernard, Balvay, Aurélie, Foussier, Anne, Charpagne, Aline, Boizet-Bonhoure, Brigitte, Chou, Chieh Jason, Naef, Felix and Gachon, Frédéric (2019). The mouse microbiome is required for sex-specific diurnal rhythms of gene expression and metabolism. Cell Metabolism, 29 (2), 362-382. doi: 10.1016/j.cmet.2018.09.023

PGC1α and exercise adaptations in zebrafish

Parisi, Alice, Blattmann, Peter, Lizzo, Giulia, Stutz, Vivienne, Strohm, Laura, Richard, Joy, Civiletto, Gabriele, Charpagne, Aline, Raymond, Frederic, Gobet, Cedric, Weger, Benjamin, Migliavacca, Eugenia, Aebersold, Ruedi, Spiegelman, Bruce and Gut, Philipp (2018). PGC1α and exercise adaptations in zebrafish. BioRxiv. doi: 10.1101/483784

Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism

Weger, Meltem, Weger, Benjamin D., Goerling, Benjamin, Poschet, Gernot, Yildiz, Melek, Hell, Ruediger, Luy, Burkhard, Akcay, Teoman, Guran, Tulay, Dickmeis, Thomas, Mueller, Ferenc and Krone, Nils (2018). Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism. EBioMedicine, 36, 376-389. doi: 10.1016/j.ebiom.2018.09.024

Menstrual cycle rhythmicity: metabolic patterns in healthy women

Draper, C. F., Duisters, K., Weger, B., Chakrabarti, A., Harms, A. C., Brennan, L., Hankemeier, T., Goulet, L., Konz, T., Martin, F. P., Moco, S. and van der Greef, J. (2018). Menstrual cycle rhythmicity: metabolic patterns in healthy women. Scientific Reports, 8 (1) 14568. doi: 10.1038/s41598-018-32647-0

Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle

Perrin, Laurent, Loizides-Mangold, Ursula, Chanon, Stephanie, Gobet, Cedric, Hulo, Nicolas, Isenegger, Laura, Weger, Benjamin D., Migliavacca, Eugenia, Charpagne, Aline, Betts, James A., Walhin, Jean-Philippe, Templeman, Lain, Stokes, Keith, Thompson, Dylan, Tsintzas, Kostas, Robert, Maud, Howald, Cedric, Riezman, Howard, Feige, Jerome N., Karagounis, Leonidas G., Johnston, Jonathan D., Dermitzakis, Emmanouil T., Gachon, Frederic, Lefai, Etienne and Dibner, Charna (2018). Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle. eLife, 7 e34114. doi: 10.7554/eLife.34114

Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish

Weger, M., Diotel, N., Weger, B. D., Beil, T., Zaucker, A., Eachus, H. L., Oakes, J. A., do Rego, J. L., Storbeck, K. -H., Gut, P., Straehle, U., Rastegar, S., Mueller, F. and Krone, N. (2018). Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish. Journal of Neuroendocrinology, 30 (4) e12586, e12586. doi: 10.1111/jne.12586

Stem cells and the circadian clock

Weger, Meltem, Diotel, Nicolas, Dorsemans, Anne-Claire, Dickmeis, Thomas and Weger, Benjamin D. (2017). Stem cells and the circadian clock. Developmental Biology, 431 (2), 111-123. doi: 10.1016/j.ydbio.2017.09.012

Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro

Loizides-Mangold, Ursula, Perrin, Laurent, Vandereycken, Bart, Betts, James A., Walhin, Jean-Philippe, Templeman, Iain, Chanon, Stéphanie, Weger, Benjamin D., Durand, Christine, Robert, Maud, Paz Montoya, Jonathan, Moniatte, Marc, Karagounis, Leonidas G., Johnston, Jonathan D., Gachon, Frédéric, Lefai, Etienne, Riezman, Howard and Dibner, Charna (2017). Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro. Proceedings of the National Academy of Sciences, 114 (41), E8565-E8574. doi: 10.1073/pnas.1705821114

Transcriptional regulatory logic of the diurnal cycle in the mouse liver

Sobel, Jonathan Aryeh, Krier, Irina, Andersin, Teemu, Raghav, Sunil, Canella, Donatella, Gilardi, Federica, Kalantzi, Alexandra Styliani, Rey, Guillaume, Weger, Benjamin, Gachon, Frederic, Dal Peraro, Matteo, Hernandez, Nouria, Schibler, Ueli, Deplancke, Bart and Naef, Felix (2017). Transcriptional regulatory logic of the diurnal cycle in the mouse liver. Plos Biology, 15 (4) e2001069, e2001069. doi: 10.1371/journal.pbio.2001069

Regulation of mammalian physiology by interconnected circadian and feeding rhythms

Atger, Florian, Mauvoisin, Daniel, Weger, Benjamin, Gobet, Cedric and Gachon, Frederic (2017). Regulation of mammalian physiology by interconnected circadian and feeding rhythms. Frontiers in Endocrinology, 8 (MAR) 42. doi: 10.3389/fendo.2017.00042

Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish

Tsachaki, Maria, Meyer, Arne, Weger, Benjamin, Kratschmar, Denise V., Tokarz, Janina, Adamski, Jerzy, Belting, Heinz-Georg, Affolter, Markus, Dickmeis, Thomas and Odermatt, Alex (2017). Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish. Journal of Endocrinology, 232 (2), 323-335. doi: 10.1530/joe-16-0495

Extensive regulation of diurnal transcription and metabolism by glucocorticoids

Weger, Benjamin D., Weger, Meltem, Goerling, Benjamin, Schink, Andrea, Gobet, Cedric, Keime, Celine, Poschet, Gernot, Jost, Bernard, Krone, Nils, Hell, Ruediger, Gachon, Frederic, Luy, Burkhard and Dickmeis, Thomas (2016). Extensive regulation of diurnal transcription and metabolism by glucocorticoids. PLoS Genetics, 12 (12) e1006512, e1006512. doi: 10.1371/journal.pgen.1006512

Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver

Atger, Florian, Gobet, Cedric, Marquis, Julien, Martin, Eva, Wang, Jingkui, Weger, Benjamin, Lefebvre, Gregory, Descombes, Patrick, Naef, Felix and Gachon, Frederic (2015). Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver. Proceedings of the National Academy of Sciences of the United States of America, 112 (47), E6579-E6588. doi: 10.1073/pnas.1515308112

Molecular description of eye defects in the zebrafish Pax6b mutant, sunrise, reveals a Pax6b-dependent genetic network in the developing anterior chamber

Takamiya, Masanari, Weger, Benjamin D., Schindler, Simone, Beil, Tanja, Yang, Lixin, Armant, Olivier, Ferg, Marco, Schlunck, Guenther, Reinhard, Thomas, Dickmeis, Thomas, Rastegar, Sepand and Straehle, Uwe (2015). Molecular description of eye defects in the zebrafish Pax6b mutant, sunrise, reveals a Pax6b-dependent genetic network in the developing anterior chamber. PLoS One, 10 (2) e0117645, e0117645. doi: 10.1371/journal.pone.0117645

The circadian clock and glucocorticoids - Interactions across many time scales

Dickmeis, Thomas, Weger, Benjamin D. and Weger, Meltem (2013). The circadian clock and glucocorticoids - Interactions across many time scales. Molecular and Cellular Endocrinology, 380 (1-2), 2-15. doi: 10.1016/j.mce.2013.05.012

A chemical screening procedure for glucocorticoid signaling with a zebrafish larva luciferase reporter system

Weger, Benjamin D., Weger, Meltem, Jung, Nicole, Lederer, Christin, Braese, Stefan and Dickmeis, Thomas (2013). A chemical screening procedure for glucocorticoid signaling with a zebrafish larva luciferase reporter system. Journal of Visualized Experiments (79) e50439. doi: 10.3791/50439

Real-time in vivo monitoring of circadian E-box enhancer activity: a robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock

Weger, Meltem, Weger, Benjamin D., Diotel, Nicolas, Rastegar, Sepand, Hirota, Tsuyoshi, Kay, Steve A., Straehle, Uwe and Dickmeis, Thomas (2013). Real-time in vivo monitoring of circadian E-box enhancer activity: a robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock. Developmental Biology, 380 (2), 259-273. doi: 10.1016/j.ydbio.2013.04.035

A chemical screening system for glucocorticoid stress hormone signaling in an intact vertebrate

Weger, Benjamin D., Weger, Meltem, Nusser, Michael, Brenner-Weiss, Gerald and Dickmeis, Thomas (2012). A chemical screening system for glucocorticoid stress hormone signaling in an intact vertebrate. ACS Chemical Biology, 7 (7), 1178-1183. doi: 10.1021/cb3000474

The light responsive transcriptome of the zebrafish: function and regulation

Weger, Benjamin D., Sahinbas, Meltem, Otto, Georg W., Mracek, Philipp, Armant, Olivier, Dolle, Dirk, Lahiri, Kajori, Vallone, Daniela, Ettwiller, Laurence, Geisler, Robert, Foulkes, Nicholas S. and Dickmeis, Thomas (2011). The light responsive transcriptome of the zebrafish: function and regulation. PloS One, 6 (2) e17080, e17080. doi: 10.1371/journal.pone.0017080

A role for caveolar proteins in regulation of the circadian clock

Fonseka, Sachini, Weger, Benjamin D., Weger, Meltem, Martel, Nick, Hall, Thomas Edward, Varasteh Moradi, Shayli, Gabriel, Christian H., Kramer, Achim, Ferguson, Charles, Fernández-Rojo, Manuel A., Alexandrov, Kirill, Rawashdeh, Oliver, McMahon, Kerrie-Ann, Gachon, Frederic and Parton, Robert G. (2022). A role for caveolar proteins in regulation of the circadian clock.

Mice with humanized livers reveal the involvement of hepatocyte circadian clocks in rhythmic behavior and physiology

Delbès, Anne-Sophie, Quiñones, Mar, Gobet, Cédric, Castel, Julien, Denis, Raphaël G. P., Berthelet, Jérémy, Weger, Benjamin D., Challet, Etienne, Charpagne, Aline, Metairon, Sylviane, Piccand, Julie, Kraus, Marine, Rohde, Bettina H., Bial, John, Wilson, Elizabeth M., Vedin, Lise-Lotte, Minniti, Mirko E., Pedrelli, Matteo, Parini, Paolo, Gachon, Frédéric and Luquet, Serge (2022). Mice with humanized livers reveal the involvement of hepatocyte circadian clocks in rhythmic behavior and physiology.