Research Fellow - Biomaterials Engi
Overview
With an ageing population, maintaining productivity and participation in society as we age represents one of global greatest challenges in the next 50 years. Whilst the prospect of autologous perivascular stem cell-based products for repairing musculoskeletal tissue damage or deficits has tremendous potential for improving the quality of life of Aging societies, this potential will remain largely unrealised if we cannot address their acquisition of early senescence in culture. My research focuses on synthesising novel glycan-binding polymers that can mimic the function of lectins to invoke a perivascular stem cells adhesion, spreading, and expansion in the multipotent state on substrates mechanically matched to the perivascular niche.
In line with my background as a Materials Engineer, I have also been working on fabrication of a robust, reliable and scalable 3D printed scaffold for functional organ replacement using our developing polymer-based bioinks. These novel bioinks that synthesised using our high-throughput, automatable system enables the bioprinting of an individual’s ‘own’ multicellular organ for use in patient-specific drug or biotherapeutic screening discovery, and ultimately functional organ replacement.
I completed my PhD at The University of Queensland's Australian Institute for Bioengineering and Nanotechnology (AIBN) under the supervision of Prof. Justin Cooper-White and A/Prof Allison Pettit, in the development of biomimetic multilayered nano-fibrous scaffolds for guided bone regeneration.
Research Interests
- Developing 3D bioprinting platforms to model and study the human perivascular niche
Research Impacts
Our projected outcomes from this research are significant, innovative, and impactful, adressing an “Advanced Manufacturing" challenges of “specialised high-performance materials". We will offer a possible path to such patient-specific regenerative solutions through the removal of fundamental materials design and processing roadblocks that we will focus on in this proposal. My project will furthermore lead to a higher quality of life in those requiring cell therapy through the provision of higher quality, higher functioning bio-printed starting points in the tissue engineering pipeline.
Translation of cells into functional tissue engineered products, enabling Australia to play a substantive role in the global cell therapy market, expected to reach $330 million by 2020, at a compound annual growth rate of ~40% from 2015 to 2020, will have significant economic impact and benefit. The new linkages that arise from these projects will have clear benefits for the Australian scientific and industrial communities, including stimulating local expertise and enhanced international reputation.
Qualifications
- Doctor of Philosophy, The University of Queensland
Publications
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Journal Article: Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution
Taherian Fard, Atefeh, Leeson, Hannah C., Aguado, Julio, Pietrogrande, Giovanni, Power, Dominique, Gómez-Inclán, Cecilia, Zheng, Huiwen, Nelson, Christopher B., Soheilmoghaddam, Farhad, Glass, Nick, Dharmaratne, Malindrie, Watson, Ebony R., Lu, Jennifer, Martin, Sally, Pickett, Hilda A., Cooper-White, Justin, Wolvetang, Ernst J. and Mar, Jessica C. (2023). Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution. GeroScience, 1-17. doi: 10.1007/s11357-023-00829-y
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Journal Article: Biophysical properties of hydrogels for mimicking tumor extracellular matrix
Cameron, Anna P., Zeng, Bijun, Liu, Yun, Wang, Haofei, Soheilmoghaddam, Farhad, Cooper-White, Justin and Zhao, Chun-Xia (2022). Biophysical properties of hydrogels for mimicking tumor extracellular matrix. Biomaterials Advances, 136 212782, 212782. doi: 10.1016/j.bioadv.2022.212782
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Journal Article: Development of regenerated cellulose/citric acid films with ionic liquids
Soheilmoghaddam, Farhad, Sharifzadeh, Ghorbanali, Adelnia, Hossein and Wahit, Mat Uzir (2021). Development of regenerated cellulose/citric acid films with ionic liquids. Journal of Polymers and the Environment, 30 (2), 613-621. doi: 10.1007/s10924-021-02218-y
Supervision
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Overcoming roadblocks in mammalian cell biomanufacturing
Doctor Philosophy
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A synthetic hyaluronic acid mimetic hairy colloidal hydrogel to mimic cell-matrix interaction
Master Philosophy
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Design, optimisation, and fabrication of patient-specific multi-phasic total disc replacements to address accelerated degenerative disc disease
Doctor Philosophy
Publications
Book Chapter
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Mohammad, Soheilmoghaddam, Raheleh, Heidar Pour, Wahit, Mat Uzir and Harintharavimal, Balakrishnan (2015). Bionanocomposites of regenerated cellulose reinforced with halloysite nanoclay and Graphene nanoplatelets: characterizations and properties. Eco-friendly polymer nanocomposites: processing and properties. (pp. 295-321) edited by Vijay Kumar Thakur and Manju Kumari Thakur. New Delhi, India: Springer. doi: 10.1007/978-81-322-2470-9_10
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Soheilmoghaddam, Mohammad, Wahit, Mat Uzir and Balakrishnan, Harintharavimal (2014). Recent developments in montmorillonite and sepiolite filled regenerated cellulose nanocomposites: Characterizations and properties. Polymer-Matrix Composites: Types, Applications and Performance. (pp. 37-56) New York, NY, United States: Nova Science Publishers.
Journal Article
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Taherian Fard, Atefeh, Leeson, Hannah C., Aguado, Julio, Pietrogrande, Giovanni, Power, Dominique, Gómez-Inclán, Cecilia, Zheng, Huiwen, Nelson, Christopher B., Soheilmoghaddam, Farhad, Glass, Nick, Dharmaratne, Malindrie, Watson, Ebony R., Lu, Jennifer, Martin, Sally, Pickett, Hilda A., Cooper-White, Justin, Wolvetang, Ernst J. and Mar, Jessica C. (2023). Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution. GeroScience, 1-17. doi: 10.1007/s11357-023-00829-y
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Biophysical properties of hydrogels for mimicking tumor extracellular matrix
Cameron, Anna P., Zeng, Bijun, Liu, Yun, Wang, Haofei, Soheilmoghaddam, Farhad, Cooper-White, Justin and Zhao, Chun-Xia (2022). Biophysical properties of hydrogels for mimicking tumor extracellular matrix. Biomaterials Advances, 136 212782, 212782. doi: 10.1016/j.bioadv.2022.212782
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Development of regenerated cellulose/citric acid films with ionic liquids
Soheilmoghaddam, Farhad, Sharifzadeh, Ghorbanali, Adelnia, Hossein and Wahit, Mat Uzir (2021). Development of regenerated cellulose/citric acid films with ionic liquids. Journal of Polymers and the Environment, 30 (2), 613-621. doi: 10.1007/s10924-021-02218-y
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High-throughput routes to biomaterials discovery
Soheilmoghaddam, Farhad, Rumble, Madeleine and Cooper-White, Justin (2021). High-throughput routes to biomaterials discovery. Chemical Reviews, 121 (18) acs.chemrev.0c01026, 10792-10864. doi: 10.1021/acs.chemrev.0c01026
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Biocompatible regenerated cellulose/halloysite nanocomposite fibers
Sharifzadeh, Ghorbanali, Soheilmoghaddam, Mohammad, Adelnia, Hossein, Wahit, Mat Uzir, Arzhandi, Masood Rezaei Dasht and Moslehyani, Ali (2020). Biocompatible regenerated cellulose/halloysite nanocomposite fibers. Polymer Engineering and Science, 60 (6), 1169-1176. doi: 10.1002/pen.25370
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Soheilmoghaddam, Mohammad, Padmanabhan, Harish and Cooper-White, Justin J. (2020). Biomimetic cues from poly(lactic-co-glycolic acid)/hydroxyapatite nano-fibrous scaffolds drive osteogenic commitment in human mesenchymal stem cells in the absence of osteogenic factor supplements. Biomaterials Science, 8 (20), 5677-5689. doi: 10.1039/d0bm00946f
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Soheilmoghaddam, Mohammad, Adelnia, Hossein, Sharifzadeh, Ghorbanali, Wahit, Mat Uzir, Wong, Tuck Whye and Ali Yussuf, Abdirahman (2017). Bionanocomposite regenerated cellulose/single-walled carbon nanotube films prepared using ionic liquid solvent. Cellulose, 24 (2), 811-822. doi: 10.1007/s10570-016-1151-3
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Development of ethylene-vinyl acetate composites reinforced with graphene platelets
Soheilmoghaddam, M., Adelnia, H., Bidsorkhi, H. C., Sharifzadeh, G., Wahit, M. U., Akos, N. I. and Yussuf, A. A. (2017). Development of ethylene-vinyl acetate composites reinforced with graphene platelets. Macromolecular Materials and Engineering, 302 (2) 1600260, 1600260. doi: 10.1002/mame.201600260
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Kappa-carrageenan/halloysite nanocomposite hydrogels as potential drug delivery systems
Sharifzadeh, Ghorbanali, Wahit, Mat Uzir, Soheilmoghaddam, Mohammad, Whye, Wong Tuck and Pasbakhsh, Pooria (2016). Kappa-carrageenan/halloysite nanocomposite hydrogels as potential drug delivery systems. Journal of the Taiwan Institute of Chemical Engineers, 67, 426-434. doi: 10.1016/j.jtice.2016.07.027
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Pour, Raheleh H., Hassan, Azman, Soheilmoghaddam, Mohammad and Bidsorkhi, Hossein C. (2016). Mechanical, thermal, and morphological properties of graphene reinforced polycarbonate/acrylonitrile butadiene styrene nanocomposites. Polymer Composites, 37 (6), 1633-1640. doi: 10.1002/pc.23335
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Influence of the processing methods on the properties of poly(lactic acid)/halloysite nanocomposites
De Silva, Rangika Thilan, Soheilmoghaddam, Mohammad, Goh, Kheng Lim, Wahit, Mat Uzir, Bee, Sharifah Abd Hamid, Chai, Siang-Piao and Pasbakhsh, Pooria (2016). Influence of the processing methods on the properties of poly(lactic acid)/halloysite nanocomposites. Polymer Composites, 37 (3), 861-869. doi: 10.1002/pc.23244
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Moslehyani, A., Mobaraki, M., Ismail, A. F., Matsuura, T., Hashemifard, S. A., Othman, M. H. D., Mayahi, A., Rezaei Dashtarzhandi, M., Soheilmoghaddam, M. and Shamsaei, E. (2015). Effect of HNTs modification in nanocomposite membrane enhancement for bacterial removal by cross-flow ultrafiltration system. Reactive and Functional Polymers, 95 3551, 80-87. doi: 10.1016/j.reactfunctpolym.2015.08.007
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Pour, Raheleh Heidar, Soheilmoghaddam, Mohammad, Hassan, Azman and Bourbigot, Serge (2015). Flammability and thermal properties of polycarbonate/acrylonitrile-butadiene-styrene nanocomposites reinforced with multilayer graphene. Polymer Degradation and Stability, 120, 88-97. doi: 10.1016/j.polymdegradstab.2015.06.013
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Fabrication of composite polymer particles by stabilizer-free seeded polymerization
Adelnia, Hossein, Gavgani, Jaber Nasrollah and Soheilmoghaddam, Mohammad (2015). Fabrication of composite polymer particles by stabilizer-free seeded polymerization. Colloid and Polymer Science, 293 (8), 2445-2450. doi: 10.1007/s00396-015-3675-8
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Preparation and characterization of ethylene-vinyl acetate/halloysite nanotube nanocomposites
Bidsorkhi, Hossein Cheraghi, Adelnia, Hossein, Pour, Raheleh Heidar and Soheilmoghaddam, Mohammad (2015). Preparation and characterization of ethylene-vinyl acetate/halloysite nanotube nanocomposites. Journal of Materials Science, 50 (8), 3237-3245. doi: 10.1007/s10853-015-8891-6
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Regenerated cellulose/beta-cyclodextrin scaffold prepared using ionic liquid
Soheilmoghaddam, Mohammad, Sharifzadeh, Ghorbanali, Pour, Raheleh Heidar, Wahit, Mat Uzir, Whye, Wong Tuck and Lee, Xiau Yeen (2014). Regenerated cellulose/beta-cyclodextrin scaffold prepared using ionic liquid. Materials Letters, 135, 210-213. doi: 10.1016/j.matlet.2014.07.169
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Bidsorkhi, Hossein Cheraghi, Soheilmoghaddam, Mohammad, Pour, Raheleh Heidar, Adelnia, Hossein and Mohamad, Zurina (2014). Mechanical, thermal and flammability properties of ethylene-vinyl acetate (EVA)/sepiolite nanocomposites. Polymer Testing, 37, 117-122. doi: 10.1016/j.polymertesting.2014.05.007
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A novel poly(xylitol-co-ledodecanedioate)/hydroxyapatite composite with shape-memory behaviour
Wong, Tuck Whye, Wahit, Mat Uzir, Kadir, Mohammed Rafiq Abdul, Soheilmoghaddam, Mohammad and Balakrishnan, Harintharavimal (2014). A novel poly(xylitol-co-ledodecanedioate)/hydroxyapatite composite with shape-memory behaviour. Materials Letters, 126, 105-108. doi: 10.1016/j.matlet.2014.04.020
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Soheilmoghaddam, Mohammad, Pasbakhsh, Pooria, Wahit, Mat Uzir, Bidsorkhi, Hossein Cheraghi, Pour, Raheleh Heidar, Whye, Wong Tuck and De Silva, R. T. (2014). Regenerated cellulose nanocomposites reinforced with exfoliated graphite nanosheets using BMIMCL ionic liquid. Polymer, 55 (14), 3130-3138. doi: 10.1016/j.polymer.2014.05.021
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Soheilmoghaddam, Mohammad, Wahit, Mat Uzir, Whye, Wong Tuck, Akos, Noel Ibrahim, Pour, Raheleh Heidar and Yussuf, Abdirahman Ali (2014). Bionanocomposites of regenerated cellulose/zeolite prepared using environmentally benign ionic liquid solvent. Carbohydrate Polymers, 106 (1), 326-334. doi: 10.1016/j.carbpol.2014.02.085
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Soheilmoghaddam, Mohammad, Wahit, Mat Uzir, Yussuf, Abdirahman Ali, Al-Saleh, Mohammad A. and Whye, Wong Tuck (2014). Characterization of bio regenerated cellulose/sepiolite nanocomposite films prepared via ionic liquid. Polymer Testing, 33, 121-130. doi: 10.1016/j.polymertesting.2013.11.011
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Development of regenerated cellulose/halloysites nanocomposites via ionic liquids
Hanid, Nurbaiti Abdul, Wahit, Mat Uzir, Guo, Qipeng, Mahmoodian, Shaya and Soheilmoghaddam, Mohammad (2014). Development of regenerated cellulose/halloysites nanocomposites via ionic liquids. Carbohydrate Polymers, 99, 91-97. doi: 10.1016/j.carbpol.2013.07.080
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Regenerated cellulose/epoxidized natural rubber blend film
Soheilmoghaddam, Mohammad, Wahit, Mat Uzir and Akos, Noel Ibrahim (2013). Regenerated cellulose/epoxidized natural rubber blend film. Materials Letters, 111, 221-224. doi: 10.1016/j.matlet.2013.08.109
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Regenerated cellulose/halloysite nanotube nanocomposite films prepared with an ionic liquid
Soheilmoghaddam, Mohammad, Wahit, Mat Uzir, Mahmoudian, Shaya and Hanid, Nurbaiti Abdul (2013). Regenerated cellulose/halloysite nanotube nanocomposite films prepared with an ionic liquid. Materials Chemistry and Physics, 141 (2-3), 936-943. doi: 10.1016/j.matchemphys.2013.06.029
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Development of regenerated cellulose/halloysite nanotube bionanocomposite films with ionic liquid
Soheilmoghaddam, Mohammad and Wahit, Mat Uzir (2013). Development of regenerated cellulose/halloysite nanotube bionanocomposite films with ionic liquid. International Journal of Biological Macromolecules, 58, 133-139. doi: 10.1016/j.ijbiomac.2013.03.066
Other Outputs
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Biomimetic multilayered nano-fibrous scaffolds for guided bone regeneration
Soheilmoghaddam, Mohammad (2019). Biomimetic multilayered nano-fibrous scaffolds for guided bone regeneration. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland. doi: 10.14264/uql.2019.815
PhD and MPhil Supervision
Current Supervision
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Overcoming roadblocks in mammalian cell biomanufacturing
Doctor Philosophy — Associate Advisor
Other advisors:
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A synthetic hyaluronic acid mimetic hairy colloidal hydrogel to mimic cell-matrix interaction
Master Philosophy — Associate Advisor
Other advisors:
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Design, optimisation, and fabrication of patient-specific multi-phasic total disc replacements to address accelerated degenerative disc disease
Doctor Philosophy — Associate Advisor
Other advisors:
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Pericytes mediated intervertebral disc regeneration in a small animal model
Doctor Philosophy — Associate Advisor
Other advisors:
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Enhancing recovery post traumatic brain injury with reparative hydrogels
Doctor Philosophy — Associate Advisor
Other advisors:
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Dynamics, Rheology and Printability of Bioactive Hairy Colloids
Doctor Philosophy — Associate Advisor
Other advisors:
