The University of Queensland

Dietary AGEs in the development and progression of chronic kidney disease

Fotheringham, Amelia K., Gallo, Linda A. and Forbes, Josephine M. (2018). Dietary AGEs in the development and progression of chronic kidney disease. Dietary AGEs and their role in health and disease. (pp. 213-224) edited by Jaime Uribarri. Boca Raton, FI, United States: CRC Press. doi: 10.1201/9781315120041

Advanced glycation end products and inflammation in type 1 diabetes development

Du, Chenping, Whiddett, Rani O., Buckle, Irina, Chen, Chen, Forbes, Josephine M. and Fotheringham, Amelia K. (2022). Advanced glycation end products and inflammation in type 1 diabetes development. Cells, 11 (21) 3503, 1-18. doi: 10.3390/cells11213503

Advanced glycation end products (AGEs) and chronic kidney disease: does the modern diet AGE the kidney?

Fotheringham, Amelia K., Gallo, Linda A., Borg, Danielle J. and Forbes, Josephine M. (2022). Advanced glycation end products (AGEs) and chronic kidney disease: does the modern diet AGE the kidney?. Nutrients, 14 (13) 2675, 1-28. doi: 10.3390/nu14132675

Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells

Leung, Sherman S., Borg, Danielle J., McCarthy, Domenica A., Boursalian, Tamar E., Cracraft, Justen, Zhuang, Aowen, Fotheringham, Amelia K., Flemming, Nicole, Watkins, Thomas, Miles, John J., Groop, Per-Henrik, Scheijen, Jean L., Schalkwijk, Casper G., Steptoe, Raymond J., Radford, Kristen J., Knip, Mikael and Forbes, Josephine M. (2022). Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells. Diabetes, 71 (9), 1994-2008. doi: 10.2337/db22-0177

Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure

Fotheringham, Amelia K., Solon-Biet, Samantha M., Bielefeldt-Ohmann, Helle, McCarthy, Domenica A., McMahon, Aisling C., Ruohonen, Kari, Li, Isaac, Sullivan, Mitchell A., Whiddett, Rani O., Borg, Danielle J., Cogger, Victoria C., Ballard, William O., Turner, Nigel, Melvin, Richard G., Raubenheimer, David, Le Couteur, David G., Simpson, Stephen J. and Forbes, Josephine M. (2021). Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure. iScience, 24 (11) 103308, 103308. doi: 10.1016/j.isci.2021.103308

Adherence to dietary and physical activity guidelines in Australian undergraduate biomedical students and associations with body composition and metabolic health: a cross-sectional study

Gallo, Linda A., Gallo, Tania F., Young, Sophia L., Fotheringham, Amelia K., Barclay, Johanna L., Walker, Jacqueline L., Moritz, Karen M. and Akison, Lisa K. (2021). Adherence to dietary and physical activity guidelines in Australian undergraduate biomedical students and associations with body composition and metabolic health: a cross-sectional study. Nutrients, 13 (10) 3500, 3500. doi: 10.3390/nu13103500

T cell expression and release of kidney injury molecule-1 in response to glucose variations initiates kidney injury in early diabetes

Forbes, Josephine M., McCarthy, Domenica A., Kassianos, Andrew J., Baskerville, Tracey, Fotheringham, Amelia J., Giuliani, Kurt T. K., Grivei, Anca, Murphy, Andrew J., Flynn, Michelle C., Sullivan, Mitchell A., Chandrashekar, Preeti, Whiddett, Rani, Radford, Kristen J., Flemming, Nicole, Beard, Sam S., D’Silva, Neisha, Nisbet, Janelle, Morton, Adam, Teasdale, Stephanie, Russell, Anthony, Isbel, Nicole, Jones, Timothy, Couper, Jennifer, Healy, Helen, Harris, Mark, Donaghue, Kim, Johnson, David W., Cotterill, Andrew, Barrett, Helen L. and O’Moore-Sullivan, Trisha (2021). T cell expression and release of kidney injury molecule-1 in response to glucose variations initiates kidney injury in early diabetes. Diabetes, 70 (8), 1754-1766. doi: 10.2337/db20-1081

Short duration alagebrium chloride therapy prediabetes does not inhibit progression to autoimmune diabetes in an experimental model

Borg, Danielle J., Faridi, Pouya, Giam, Kai Lin, Reeves, Peta, Fotheringham, Amelia K., McCarthy, Domenica A., Leung, Sherman, Ward, Micheal S., Harcourt, Brooke E., Ayala, Rochelle, Scheijen, Jean L., Briskey, David, Dudek, Nadine L., Schalkwijk, Casper G., Steptoe, Raymond, Purcell, Anthony W. and Forbes, Josephine M. (2021). Short duration alagebrium chloride therapy prediabetes does not inhibit progression to autoimmune diabetes in an experimental model. Metabolites, 11 (7) 426, 1-21. doi: 10.3390/metabo11070426

Advanced glycation end products as predictors of renal function in youth with type 1 diabetes

Forbes, Josephine M., Le Bagge, Selena, Righi, Samuel, Fotheringham, Amelia K., Gallo, Linda A., McCarthy, Domenica A., Leung, Sherman, Baskerville, Tracey, Nisbett, Janelle, Morton, Adam, Teasdale, Stephanie, D'Silva, Neisha, Barrett, Helen, Jones, Timothy, Couper, Jennifer, Donaghue, Kim, Isbel, Nicole, Johnson, David W., Donnellan, Leigh, Deo, Permal, Akison, Lisa K., Moritz, Karen M. and O'Moore-Sullivan, Trisha (2021). Advanced glycation end products as predictors of renal function in youth with type 1 diabetes. Scientific Reports, 11 (1) 9422, 9422. doi: 10.1038/s41598-021-88786-4

The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition)

Zhuang, Aowen, Yap, Felicia Y. T., Borg, Danielle J., McCarthy, Domenica, Fotheringham, Amelia, Leung, Sherman, Penfold, Sally A., Sourris, Karly C., Coughlan, Melinda T., Schulz, Benjamin L. and Forbes, Josephine M. (2021). The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition). Endocrinology, Diabetes and Metabolism, 4 (3) e00278, e00278. doi: 10.1002/edm2.278

Circulating levels of the soluble receptor for AGE (sRAGE) during escalating oral glucose dosages and corresponding isoglycaemic i.v. glucose infusions in individuals with and without type 2 diabetes

Fotheringham, Amelia K., Bagger, Jonatan I., Borg, Danielle J., McCarthy, Domenica A., Holst, Jens J., Vilsbøll, Tina, Knop, Filip K. and Forbes, Josephine M. (2020). Circulating levels of the soluble receptor for AGE (sRAGE) during escalating oral glucose dosages and corresponding isoglycaemic i.v. glucose infusions in individuals with and without type 2 diabetes. Nutrients, 12 (10) 2928, 2928-12. doi: 10.3390/nu12102928

Targeting the receptor for advanced glycation end products (RAGE) in type 1 diabetes

Le Bagge, Selena, Fotheringham, Amelia K., Leung, Sherman S. and Forbes, Josephine M. (2020). Targeting the receptor for advanced glycation end products (RAGE) in type 1 diabetes. Medicinal Research Reviews, 40 (4) med.21654, 1200-1219. doi: 10.1002/med.21654

Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction

Borg, Danielle J., Yap, Felicia Y. T., Keshvari, Sahar, Simmons, David G., Gallo, Linda A., Fotheringham, Amelia K., Zhuang, Aowen, Slattery, Robyn M., Hasnain, Sumaira Z., Coughlan, Melinda T., Kantharidis, Phillip and Forbes, Josephine M. (2017). Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction. Islets, 10 (1), 10-24. doi: 10.1080/19382014.2017.1405189

Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes

Ward, Micheal S.., Flemming, Nicole B., Gallo, Linda A., Fotheringham, Amelia K., McCarthy, Domenica A., Zhuang, Aowen, Tang, Peter H., Borg, Danielle J., Shaw, Hannah, Harvie, Benjamin, Briskey, David R., Roberts, Llion A., Plan, Manuel R., Murphy, Michael P., Hodson, Mark P. and Forbes, Josephine M. (2017). Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes. Scientific Reports, 7 (1) 15190, 15190. doi: 10.1038/s41598-017-15589-x

Vascular complications in diabetes: old messages, new thoughts

Forbes, Josephine M. and Fotheringham, Amelia K. (2017). Vascular complications in diabetes: old messages, new thoughts. Diabetologia, 60 (11), 2129-2138. doi: 10.1007/s00125-017-4360-x

Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice

Gallo, Linda A., Ward, Micheal S., Fotheringham, Amelia K., Zhuang, Aowen, Borg, Danielle J., Flemming, Nicole B., Harvie, Ben M., Kinneally, Toni L., Yeh, Shang-Ming, McCarthy, Domenica A., Koepsell, Hermann, Vallon, Volker, Pollock, Carol, Panchapakesan, Usha and Forbes, Josephine M. (2016). Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice. Scientific Reports, 6 (1) 26428, 28124. doi: 10.1038/srep26428

Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes

Tesch, Greg, Sourris, Karly C., Summers, Shaun A., McCarthy, Domenica, Ward, Micheal S., Borg, Danielle J., Gallo, Linda A., Fotheringham, Amelia K., Pettit, Allison R., Yap, Felicia Y. T., Harcourt, Brooke E., Tan, Adeline L. Y., Kausman, Joshua Y., Nikolic-Paterson, David, Kitching, Arthur R. and Forbes, Josephine M. (2014). Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes. Diabetologia, 57 (9), 1977-1985. doi: 10.1007/s00125-014-3291-z

Rapid genome wide mapping of phosphine resistance loci by a simple regional averaging analysis in the red flour beetle, Tribolium castaneum

Jagadeesan, Rajeswaran, Fotheringham, Amelia, Ebert, Paul R. and Schlipalius, David I. (2013). Rapid genome wide mapping of phosphine resistance loci by a simple regional averaging analysis in the red flour beetle, Tribolium castaneum. Bmc Genomics, 14 (1) 650, 650.1-650.11. doi: 10.1186/1471-2164-14-650

Targeting advanced glycation endproducts and mitochondrial dysfunction in cardiovascular disease

Ward, Micheal S., Fortheringham, Amelia K., Cooper, Mark E . and Forbes, Josephine M. (2013). Targeting advanced glycation endproducts and mitochondrial dysfunction in cardiovascular disease. Current Opinion in Pharmacology, 13 (4), 654-661. doi: 10.1016/j.coph.2013.06.009

Mitochondrial dysfunction aligns with risk for diabetic kidney disease in youth with type 1 diabetes

Sullivan, Mitchell, McCarthy, Domenica, Flemming, Nicole, Chandrashekar, Preeti, Hodson, Mark, Fotheringham, Amelia, Whiddett, Rani, De Silva, Neisha, Nisbet, Jinelle, Morton, Adam, Teasdale, Stephanie, Isbel, Nicole, Jones, Timothy, Couper, Jennier, Thorburn, David, Johnson, David, Cotterill, Andrew, Barrett, Helen, O'Moore-Sullivan, Trisha, Donaghue, Kim and Forbes, Josephine (2022). Mitochondrial dysfunction aligns with risk for diabetic kidney disease in youth with type 1 diabetes. 57th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Sydney, NSW, Australia, 17–19 October 2022. Richmond, VIC, Australia: John Wiley & Sons.

Exploring AGE and sRAGE regulation in response to oral and intravenous glucose loads in individuals with recently diagnosed type 2 diabetes

Fotheringham, A. K., Bagger, J. I., Borg, D. J., McCarthy, D., Vilsboll, T., Knop, F. K. and Forbes, J. M. (2019). Exploring AGE and sRAGE regulation in response to oral and intravenous glucose loads in individuals with recently diagnosed type 2 diabetes. 55th Annual Meeting of the European Association for the Study of Diabetes (EASD), Barcelona, Spain, 16-20 September 2019 . New York, NY, United States: Springer.

Body composition to estimate percentage fat mass: comparisons between common clinical methods and gold-standard air displacement plethysmography (BODPOD) in a cohort of university students

Akison, Lisa K., Gallo, Linda A., Barclay, Johanna L., Burgess, Danielle, Keshvari, Sahar, Fotheringham, Amelia K. and Moritz, Karen M. (2018). Body composition to estimate percentage fat mass: comparisons between common clinical methods and gold-standard air displacement plethysmography (BODPOD) in a cohort of university students. Joint Annual Scientific Meetings of Endocrine Society of Australia (ESA) and Society for Reproductive Biology (SRB), Perth, Australia, 27-30 August 2017. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

Glucose and insulin profiles during an oral glucose tolerance test (oGTT) are similar between fed and fasted states in a cohort of university students

Akison, Lisa K., Gallo, Linda A., Barclay, Johanna L., Zhuang, Aowen, Chen, Cortina, Fotheringham, Amelia K. and Moritz, Karen M. (2018). Glucose and insulin profiles during an oral glucose tolerance test (oGTT) are similar between fed and fasted states in a cohort of university students. Joint Annual Scientific Meetings of Endocrine Society of Australia (ESA) and Society for Reproductive Biology (SRB), Perth, Australia, 27-30 August 2017. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

Using the Geometric Framework to Explore the Longitudinal Effects of Dietary Macronutrient Consumption On Markers of Kidney Aging

Fotheringham, A. K., Solon-Biet, S. M., Mcmahon, A. C., Ballard, W. O., Ruohonen, K., Borg, D. J., Raubenheimer, D., Le Couteur, D. G., Simpson, S. J. and Forbes, J. M. (2017). Using the Geometric Framework to Explore the Longitudinal Effects of Dietary Macronutrient Consumption On Markers of Kidney Aging. HOBOKEN: WILEY.

Understanding Novel Genetic Factors Underlying Circulating Cystatin C and Kidney Function

Fotheringham, A., Balmer, L., Morahan, G. and Forbes, J. (2016). Understanding Novel Genetic Factors Underlying Circulating Cystatin C and Kidney Function. HOBOKEN: WILEY-BLACKWELL.

Human soluble receptor for advanced glycation end products therapy reduces autoimmune diabetes in the non-obese diabetic mouse

Leung, S. S.-Y., Borg, D. J., McCarthy, D., Zhuang, A., Fotheringham, A., Di Trapani, G., Groop, P.-H., Knip, M. and Forbes, J. (2015). Human soluble receptor for advanced glycation end products therapy reduces autoimmune diabetes in the non-obese diabetic mouse. Joint Annual Conference of the International Society for Pediatric and Adolescent Diabetes and Australasian Paediatric Endocrine Group (ISPAD+APEG 2015), Brisbane, QLD Australia, 7-10 October 2015. Hoboken, NJ USA: Wiley-Blackwell Publishing. doi: 10.1111/pedi.12309

Delivery of recombinant human soluble receptor for advanced glycation end products delays autoimmune diabetes in the NOD mouse model

Borg, D. J., Leung, S., Zhuang, A., Fotheringham, A., McCarthy, D., Di Trapani, J., Groop, P. -H., Knip, M. and Forbes, J. (2015). Delivery of recombinant human soluble receptor for advanced glycation end products delays autoimmune diabetes in the NOD mouse model. 51st Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Stockholm, Sweden, 14-18 September 2015. Heidelberg, Germany: Springer. doi: 10.1007/s00125-015-3687-4

In Db/db mice, Sglt2 inhibition does not improve diabetic nephropathy despite glycaemic improvements

Gallo, L. A., Ward, M. S., Fotheringham, A. K., Pollock, C., Panchapakesan, U. and Forbes, J. M. (2015). In Db/db mice, Sglt2 inhibition does not improve diabetic nephropathy despite glycaemic improvements. 51st Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Canberra, Australia, 7-9 September 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12543

Short-term alagebrium chloride (ALT-711) therapy pre-diabetes for the treatment of Type I Diabetes

Borg, D. J., McCarthy, D., Reeves, P., Ward, M. S., Fotheringham, A. K., Gallo, L. A., Harcourt, B. E., Agrawal, N., Steptoe, R. and Forbes, J. M. (2015). Short-term alagebrium chloride (ALT-711) therapy pre-diabetes for the treatment of Type I Diabetes. Immunology of Diabetes Society 14th International Congress, Munich, Germany, 12-16 April 2015.

Ager1 overexpression in glomerular podocytes results in renal disease which is exacerbated by diabetes

Zhuang, A., Sourris, K. C, Harcourt, B. E, Penfold, S. A., Fotheringham, A. K., McCarthy, D., Schulz, B. and Forbes, J. M. (2014). Ager1 overexpression in glomerular podocytes results in renal disease which is exacerbated by diabetes. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne VIC, Australia, 25 - 27 August 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12301

Deficiency of rage in bone marrow cells reduces renal injury in diabetic mice

Tesch, G. H., Sourris, K. C., Summers, S. A., Mccarthy, D., Ward, M. S., Borg, D. J., Gallo, L. A., Fotheringham, A. K., Pettit, A., Yap, F. Y. T., Harcourt, B. E., Tan, A. L. Y., Kausman, J. Y., Nikolic-Paterson, D. J., Kitching, A. R. and Forbes, J. M. (2014). Deficiency of rage in bone marrow cells reduces renal injury in diabetic mice. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne Australia, 25–27 August 2014. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12301

Flux of advanced glycation end products across the kidney as a contributor to renal disease in diabetes

Leung, C., Fotheringham, A. K., Zhuang, A., Borg, D. J., Ward, M. S., Coughlan, M. T., Mccarthy, D. A., Gallo, L. A., Harcourt, B. E. and Forbes, J. M. (2014). Flux of advanced glycation end products across the kidney as a contributor to renal disease in diabetes. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne, Australia, 25–27 August 2014. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12302

Glyoxalase-1 Inhibition Leads to Podocyte Insulin Resistance and Features Resembling Diabetic Kidney Disease

Gallo, Linda A., Ward, Micheal S., Harcourt, Brooke E., Fotheringham, Amelia K., McCarthy, Domenica A., Penfold, Sally A. and Forbes, Josephine M. (2014). Glyoxalase-1 Inhibition Leads to Podocyte Insulin Resistance and Features Resembling Diabetic Kidney Disease. 14th Asian Pacific Congress of Nephrology, Tokyo, Japan, 14-17 May 2014. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/nep.12236

Mitochondrial targeting of superoxide by Mitoq improves metabolic renal dysfunction

Ward, M. S., Flemming, N. B., Gallo, L. A., Fotheringham, A., Gobe, G., Vesey, D. and Forbes, J. M. (2014). Mitochondrial targeting of superoxide by Mitoq improves metabolic renal dysfunction. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne Australia, 25–27 August 2014. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12301

Methylglyoxal induced insulin resistance in podocytes contributes to diabetic kidney disease

Gallo, L. A., Harcourt, B. E., Fotheringham, A. K., McCarthy, D., Penfold, S. A. and Forbes, J. M. (2013). Methylglyoxal induced insulin resistance in podocytes contributes to diabetic kidney disease. 49th Annual Meeting of the European Association for the Study of Diabetes (EASD), Barcelona, Spain, 23 -27 September 2013. Heidelberg, Germany: Springer. doi: 10.1007/s00125-013-3012-z

Oligosaccharyltransferase-48 as a Novel Mediator of Chronic Kidney Disease in Diabetes

Zhuang, A., Harcourt, B., Sourris, K., Penfold, S., Ward, M., Fotheringham, A., Thorn, P. and Forbes, J. (2013). Oligosaccharyltransferase-48 as a Novel Mediator of Chronic Kidney Disease in Diabetes. WILEY-BLACKWELL.

Therapies which lower advanced glycation end products influence experimental autoimmune diabetes in a time dependent manner

Borg, D. J., Yap, F. Y. T., Fotheringham, A. K., Harcourt, B. E., McCarthy, D., Ward, M., Slattery, R., Coughlan, M. T., Kantharidis, P. and Forbes, J. M. (2013). Therapies which lower advanced glycation end products influence experimental autoimmune diabetes in a time dependent manner. 49th Annual Meeting of the European Association for the Study of Diabetes (EASD), Barcelona, Spain, 23 -27 September 2013. Heidelberg, Germany: Springer. doi: 10.1007/s00125-013-3012-z

Novel dietary factors in diabetic and non-diabetic kidney disease

Fotheringham, Amelia Katherine (2020). Novel dietary factors in diabetic and non-diabetic kidney disease. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/uql.2020.117

Novel dietary factors in diabetic and non-diabetic kidney disease

Fotheringham, Amelia (2019). Novel dietary factors in diabetic and non-diabetic kidney disease. PhD Thesis, Faculty of Medicine, The University of Queensland.

Novel dietary factors in diabetic and non-diabetic kidney disease

Fotheringham, Amelia (2019). Novel dietary factors in diabetic and non-diabetic kidney disease. PhD Thesis, School of Biomedical Sciences and School of Psychology, The University of Queensland.