Dr Jens Bunt

Research Fellow

Queensland Brain Institute
j.bunt@uq.edu.au
+61 7 334 66337

Overview

I am a molecular biologist / geneticist passioned about both neuro-oncology and neurodevelopment. My main interest is to understand how transcriptional and epigenetic factors that regulate proliferation and differentiation during normal brain development, are involved in pediatric brain tumours and congenital brain malformations. My main goal is discover the molecular neurodevelopmental basis of disease and to translate this knowledge to novel therapies, improved diagnosis or prognosis.

In November 2012 ,I completed my PhD at the Academic Medical Centre (Amsterdam, the Netherlands) under the supervision of Dr Marcel Kool, a world expert in genomic research in brain tumours. This research led to the discovery of the now established molecular subgroups in medulloblastoma and the identification of OTX2 as an oncogene. I discovered that OTX2 inhibits the differentiation of tumour cells and that knockdown of this gene can induce terminal differentiation of these cells. I further identified the pathways directly controlled by OTX2 and provided potential downstream targets suitable for therapy. My work has resulted in four first-author papers (Acta Neuropathol, Int J Cancer, Mol Cancer Res, PLoS One) as well as co-authorship on highly cited papers in PLoS One and Nature.

Within the Brain Development and Disorders laboratory headed by Prof. Linda Richards, I led a team, consisting of two PhD students, a research technician and undergraduate students. We investigated the function of the Nuclear factor one (NFI) family of transcription factors in normal brain development as well as in disease. NFI genes are important regulators of proliferation and differentiation of cortical progenitor cells and are disrupted in congenital brain malformations and brain tumours. To elucidate the fundamental molecular and cellular processing of NFI-driven differentiation in brain development, we generated novel genetic mouse models as well as primary brain tumour xenografts. By understanding the contribution of NFI disruption to human disease, we contribute to the improvement of diagnosis, prognosis and/or treatment. For instance, we identified NFIB haploinsufficiency as the cause of novel syndrome characterized by intellectual disability and macrocephaly.

With Prof. Richards and my team, I have published 14 papers, including in Nature Genetics, Cancer Letters, Nature Communications, American Journal of Human Genetics, Cell Reports, American Journal of Medical Genetics part C, Oncotarget and Development. These include 4 first-, 3 last and 2 second author papers. I established a number of key collaborations both locally and internationally to combine basic neuroscience, oncology and clinical genetics.

Per 15-01-2020, I am joining Prof. Marcel Kool to establish a new laboratory at Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands. Our focus will be on understanding the neurodevelopmental origin of pediatric brain tumour and to generate novel models for research and translational medicine. I will also remain involved in the research program of Prof. Richads at the Brain Development and Disorders laboratory as an collaborator and associated supervisor.

Research Impacts

The brain is a very complex structure. The development therefore requires a very strict control on the timing and the number of each different cell type formed. Small changes in this regulation can lead to very big consequences. For instance, critical brain structures such as the corpus callosum can be absent as their building blocks are not generated on time or tumours form from cells that remain diving. Both cancer and neurodevelopment defects underlying various intellectual and behavioural problems have a huge impact on patients. We try to understand their common origin in order to provide novel therapeutic options, a clear diagnosis or more accurate prognosis.

Qualifications

  • Doctor of Medicine, University of Amsterdam
  • Master of Science, Wageningen University

Publications

  • Pajtler, Kristian W., Wei, Yiju, Okonechnikov, Konstantin, Silva, Patricia B. G., Vouri, Mikaella, Zhang, Lei, Brabetz, Sebastian, Sieber, Laura, Gulley, Melissa, Mauermann, Monika, Wedig, Tatjana, Mack, Norman, Imamura Kawasawa, Yuka, Sharma, Tanvi, Zuckermann, Marc, Andreiuolo, Felipe, Holland, Eric, Maass, Kendra, Körkel-Qu, Huiqin, Liu, Hai-Kun, Sahm, Felix, Capper, David, Bunt, Jens, Richards, Linda J., Jones, David T. W., Korshunov, Andrey, Chavez, Lukas, Lichter, Peter, Hoshino, Mikio, Pfister, Stefan M., Kool, Marcel, Li, Wei and Kawauchi, Daisuke (2019) YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis. Nature Communications, 10 1: . doi:10.1038/s41467-019-11884-5

  • Schanze, Ina, Bunt, Jens, Lim, Jonathan W.C., Schanze, Denny, Dean, Ryan J., Alders, Marielle, Blanchet, Patricia, Attié-Bitach, Tania, Berland, Siren, Boogert, Steven, Boppudi, Sangamitra, Bridges, Caitlin J., Cho, Megan T., Dobyns, William B., Donnai, Dian, Douglas, Jessica, Earl, Dawn L., Edwards, Timothy J., Faivre, Laurence, Fregeau, Brieana, Genevieve, David, Gérard, Marion, Gatinois, Vincent, Holder-Espinasse, Muriel, Huth, Samuel F., Izumi, Kosuke, Kerr, Bronwyn, Lacaze, Elodie, Lakeman, Phillis, Mahida, Sonal, Mirzaa, Ghayda M., Morgan, Sian M., Nowak, Catherine, Peeters, Hilde, Petit, Florence, Pilz, Daniela T., Puechberty, Jacques, Reinstein, Eyal, Rivière, Jean-Baptiste, Santani, Avni B., Schneider, Anouck, Sherr, Elliott H., Smith-Hicks, Constance, Wieland, Ilse, Zackai, Elaine, Zhao, Xiaonan, Gronostajski, Richard M., Zenker, Martin and Richards, Linda J. (2018) NFIB haploinsufficiency is associated with intellectual disability and macrocephaly. American Journal of Human Genetics, 103 5: 752-768. doi:10.1016/j.ajhg.2018.10.006

  • Chen, Kok-Siong, Harris, Lachlan, Lim, Jonathan W. C. , Harvey, Tracey J. , Piper, Michael, Gronostajski, Richard M. , Richards, Linda J. and Bunt, Jens (2017) Differential neuronal and glial expression of nuclear factor I proteins in the cerebral cortex of adult mice. Journal of Comparative Neurology, 525 11: 2465-2483. doi:10.1002/cne.24206

  • Gobius, Ilan, Morcom, Laura, Sua´rez, Rodrigo, Bunt, Jens, Bukshpun, Polina, Reardon, William, Dobyns, William B., Rubenstein, John L.R., Barkovich, James, Sherr, Elliott H. and Richards, Linda J. (2016) Astroglial-mediated remodeling of the interhemispheric midline is required for the formation of the corpus callosum. Cell Reports, 17 3: 735-747. doi:10.1016/j.celrep.2016.09.033

  • Stringer, Brett W., Bunt, Jens, Day, Bryan W., Barry, Guy, Jamieson, Paul R., Ensbey, Kathleen S., Bruce, Zara C., Goasdoué, Kate, Vidal, Helene, Charmsaz, Sara, Smith, Fiona M., Cooper, Leanne T., Piper, Michael, Boyd, Andrew W. and Richards, Linda J. (2016) Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma. Oncotarget, 7 20: 29306-12320. doi:10.18632/oncotarget.8720

  • Kool, Marcel, Koster, Jan, Bunt, Jens, Hasselt, Nancy E., Lakeman, Arjan, van Sluis, Peter, Troost, Dirk, Schouten-van Meeteren, Netteke, Caron, Huib N., Cloos, Jacqueline, Mrsic, Alan, Ylstra, Bauke, Grajkowska, Wieslawa, Hartmann, Wolfgang, Pietsch, Torsten, Ellison, David, Clifford, Steven C. and Versteeg, Rogier (2008) Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PloS One, 3 8: e3088.1-e3088.14. doi:10.1371/journal.pone.0003088

View all Publications

Supervision

  • (2018) Doctor Philosophy

  • (2019) Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Available Projects

  • As I am moving to a new laboratory, I will not be taking on new student. If you are interested in neurodevelopment and disorders, go and visit the website of the Brain Development and Disorders lab contact or contact Prof. Linda Richards.

  • As I am moving to a new laboratory, I will not be taking on new student in Brisbane. If you are interested in neuro-oncology, go and visit the websites of the following UQ researchers:

    - Dr Zachery Houston (http://researchers.uq.edu.au/researcher/10273)

    - Dr Roberta Mazzieri (https://researchers.uq.edu.au/researcher/2763)

    - Dr Laura Genovesi (http://researchers.uq.edu.au/researcher/2786)

    Otherwise, if you want to come to the Netherlands, feel free to contact me.

View all Available Projects

Publications

Featured Publications

  • Pajtler, Kristian W., Wei, Yiju, Okonechnikov, Konstantin, Silva, Patricia B. G., Vouri, Mikaella, Zhang, Lei, Brabetz, Sebastian, Sieber, Laura, Gulley, Melissa, Mauermann, Monika, Wedig, Tatjana, Mack, Norman, Imamura Kawasawa, Yuka, Sharma, Tanvi, Zuckermann, Marc, Andreiuolo, Felipe, Holland, Eric, Maass, Kendra, Körkel-Qu, Huiqin, Liu, Hai-Kun, Sahm, Felix, Capper, David, Bunt, Jens, Richards, Linda J., Jones, David T. W., Korshunov, Andrey, Chavez, Lukas, Lichter, Peter, Hoshino, Mikio, Pfister, Stefan M., Kool, Marcel, Li, Wei and Kawauchi, Daisuke (2019) YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis. Nature Communications, 10 1: . doi:10.1038/s41467-019-11884-5

  • Schanze, Ina, Bunt, Jens, Lim, Jonathan W.C., Schanze, Denny, Dean, Ryan J., Alders, Marielle, Blanchet, Patricia, Attié-Bitach, Tania, Berland, Siren, Boogert, Steven, Boppudi, Sangamitra, Bridges, Caitlin J., Cho, Megan T., Dobyns, William B., Donnai, Dian, Douglas, Jessica, Earl, Dawn L., Edwards, Timothy J., Faivre, Laurence, Fregeau, Brieana, Genevieve, David, Gérard, Marion, Gatinois, Vincent, Holder-Espinasse, Muriel, Huth, Samuel F., Izumi, Kosuke, Kerr, Bronwyn, Lacaze, Elodie, Lakeman, Phillis, Mahida, Sonal, Mirzaa, Ghayda M., Morgan, Sian M., Nowak, Catherine, Peeters, Hilde, Petit, Florence, Pilz, Daniela T., Puechberty, Jacques, Reinstein, Eyal, Rivière, Jean-Baptiste, Santani, Avni B., Schneider, Anouck, Sherr, Elliott H., Smith-Hicks, Constance, Wieland, Ilse, Zackai, Elaine, Zhao, Xiaonan, Gronostajski, Richard M., Zenker, Martin and Richards, Linda J. (2018) NFIB haploinsufficiency is associated with intellectual disability and macrocephaly. American Journal of Human Genetics, 103 5: 752-768. doi:10.1016/j.ajhg.2018.10.006

  • Chen, Kok-Siong, Harris, Lachlan, Lim, Jonathan W. C. , Harvey, Tracey J. , Piper, Michael, Gronostajski, Richard M. , Richards, Linda J. and Bunt, Jens (2017) Differential neuronal and glial expression of nuclear factor I proteins in the cerebral cortex of adult mice. Journal of Comparative Neurology, 525 11: 2465-2483. doi:10.1002/cne.24206

  • Gobius, Ilan, Morcom, Laura, Sua´rez, Rodrigo, Bunt, Jens, Bukshpun, Polina, Reardon, William, Dobyns, William B., Rubenstein, John L.R., Barkovich, James, Sherr, Elliott H. and Richards, Linda J. (2016) Astroglial-mediated remodeling of the interhemispheric midline is required for the formation of the corpus callosum. Cell Reports, 17 3: 735-747. doi:10.1016/j.celrep.2016.09.033

  • Stringer, Brett W., Bunt, Jens, Day, Bryan W., Barry, Guy, Jamieson, Paul R., Ensbey, Kathleen S., Bruce, Zara C., Goasdoué, Kate, Vidal, Helene, Charmsaz, Sara, Smith, Fiona M., Cooper, Leanne T., Piper, Michael, Boyd, Andrew W. and Richards, Linda J. (2016) Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma. Oncotarget, 7 20: 29306-12320. doi:10.18632/oncotarget.8720

  • Kool, Marcel, Koster, Jan, Bunt, Jens, Hasselt, Nancy E., Lakeman, Arjan, van Sluis, Peter, Troost, Dirk, Schouten-van Meeteren, Netteke, Caron, Huib N., Cloos, Jacqueline, Mrsic, Alan, Ylstra, Bauke, Grajkowska, Wieslawa, Hartmann, Wolfgang, Pietsch, Torsten, Ellison, David, Clifford, Steven C. and Versteeg, Rogier (2008) Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PloS One, 3 8: e3088.1-e3088.14. doi:10.1371/journal.pone.0003088

Journal Article

  • Chen, Kok-Siong, Bridges, Caitlin R., Lynton, Zorana, Lim, Jonathan W. C., Stringer, Brett W., Rajagopal, Revathi, Wong, Kum-Thong, Ganesan, Dharmendra, Ariffin, Hany, Day, Bryan W., Richards, Linda J. and Bunt, Jens (2019) Transcription factors NFIA and NFIB induce cellular differentiation in high-grade astrocytoma. Journal of Neuro-Oncology, . doi:10.1007/s11060-019-03352-3

  • Zenker, Martin, Bunt, Jens, Schanze, Ina, Schanze, Denny, Piper, Michael, Priolo, Manuela, Gerkes, Erica H., Gronostajski, Richard M., Richards, Linda J., Vogt, Julie, Wessels, Marja W. and Hennekam, Raoul C. (2019) Variants in nuclear factor I genes influence growth and development. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, . doi:10.1002/ajmg.c.31747

  • Pajtler, Kristian W., Wei, Yiju, Okonechnikov, Konstantin, Silva, Patricia B. G., Vouri, Mikaella, Zhang, Lei, Brabetz, Sebastian, Sieber, Laura, Gulley, Melissa, Mauermann, Monika, Wedig, Tatjana, Mack, Norman, Imamura Kawasawa, Yuka, Sharma, Tanvi, Zuckermann, Marc, Andreiuolo, Felipe, Holland, Eric, Maass, Kendra, Körkel-Qu, Huiqin, Liu, Hai-Kun, Sahm, Felix, Capper, David, Bunt, Jens, Richards, Linda J., Jones, David T. W., Korshunov, Andrey, Chavez, Lukas, Lichter, Peter, Hoshino, Mikio, Pfister, Stefan M., Kool, Marcel, Li, Wei and Kawauchi, Daisuke (2019) YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis. Nature Communications, 10 1: . doi:10.1038/s41467-019-11884-5

  • Schanze, Ina, Bunt, Jens, Lim, Jonathan W.C., Schanze, Denny, Dean, Ryan J., Alders, Marielle, Blanchet, Patricia, Attié-Bitach, Tania, Berland, Siren, Boogert, Steven, Boppudi, Sangamitra, Bridges, Caitlin J., Cho, Megan T., Dobyns, William B., Donnai, Dian, Douglas, Jessica, Earl, Dawn L., Edwards, Timothy J., Faivre, Laurence, Fregeau, Brieana, Genevieve, David, Gérard, Marion, Gatinois, Vincent, Holder-Espinasse, Muriel, Huth, Samuel F., Izumi, Kosuke, Kerr, Bronwyn, Lacaze, Elodie, Lakeman, Phillis, Mahida, Sonal, Mirzaa, Ghayda M., Morgan, Sian M., Nowak, Catherine, Peeters, Hilde, Petit, Florence, Pilz, Daniela T., Puechberty, Jacques, Reinstein, Eyal, Rivière, Jean-Baptiste, Santani, Avni B., Schneider, Anouck, Sherr, Elliott H., Smith-Hicks, Constance, Wieland, Ilse, Zackai, Elaine, Zhao, Xiaonan, Gronostajski, Richard M., Zenker, Martin and Richards, Linda J. (2018) NFIB haploinsufficiency is associated with intellectual disability and macrocephaly. American Journal of Human Genetics, 103 5: 752-768. doi:10.1016/j.ajhg.2018.10.006

  • Chen, Kok-Siong, Lim, Jonathan W. C., Richards, Linda J. and Bunt, Jens (2017) The convergent roles of the nuclear factor I transcription factors in development and cancer. Cancer Letters, 410 124-138. doi:10.1016/j.canlet.2017.09.015

  • Bunt, Jens, Osinski, Jason M., Lim, Johnathon W. C., Vidovic, Diana, Ye, Yunan, Zalucki, Oressia, O'Connor, Timothy R., Harris, Lachlan, Gronostajski, Richard M., Richards, Linda J. and Piper, Michael (2017) Combined allelic dosage of Nfia and Nfib regulates cortical development. Brain and Neuroscience Advances, 1 239821281773943. doi:10.1177/2398212817739433

  • Matuzelski, Elise, Bunt, Jens, Harkins, Danyon, Lim, Jonathan W. C., Gronostajski, Richard M., Richards, Linda J., Harris, Lachlan and Piper, Michael (2017) Transcriptional regulation of Nfix by NFIB drives astrocytic maturation within the developing spinal cord. Developmental Biology, 432 2: 286-297. doi:10.1016/j.ydbio.2017.10.019

  • Chen, Kok-Siong, Harris, Lachlan, Lim, Jonathan W. C. , Harvey, Tracey J. , Piper, Michael, Gronostajski, Richard M. , Richards, Linda J. and Bunt, Jens (2017) Differential neuronal and glial expression of nuclear factor I proteins in the cerebral cortex of adult mice. Journal of Comparative Neurology, 525 11: 2465-2483. doi:10.1002/cne.24206

  • Marsh, Ashley P. L., Heron, Delphine, Edwards, Timothy J., Quartier, Angelique, Galea, Charles, Nava, Caroline, Rastetter, Agnes, Moutard, Marie-Laure, Anderson, Vicki, Bitoun, Pierre, Bunt, Jens, Faudet, Anne, Garel, Catherine, Gillies, Greta, Gobius, Ilan, Guegan, Justine, Heide, Solveig, Keren, Boris, Lesne, Fabien, Lukic, Vesna, Mandelstam, Simone A., McGillivray, George, McIlroy, Alissandra, Meneret, Aurelie, Mignot, Cyril, Morcom, Laura R., Odent, Sylvie, Paolino, Annalisa, Pope, Kate, Riant, Florence, Robinson, Gail A., Spencer-Smith, Megan, Srour, Myriam, Stephenson, Sarah E. M., Tankard, Rick, Trouillard, Oriane, Welniarz, Quentin, Wood, Amanda, Brice, Alexis, Rouleau, Guy, Attie-Bitach, Tania, Delatycki, Martin B., Mandel, Jean-Louis, Amor, David J., Roze, Emmanuel, Piton, Amelie, Bahlo, Melanie, de Villemeur, Thierry Billette, Sherr, Elliott H., Leventer, Richard J., Richards, Linda J., Lockhart, Paul J. and Depienne, Christel (2017) Mutations in DCC cause isolated agenesis of the corpus callosum with incomplete penetrance. Nature Genetics, 49 4: 511-514. doi:10.1038/ng.3794

  • Gobius, Ilan, Morcom, Laura, Sua´rez, Rodrigo, Bunt, Jens, Bukshpun, Polina, Reardon, William, Dobyns, William B., Rubenstein, John L.R., Barkovich, James, Sherr, Elliott H. and Richards, Linda J. (2016) Astroglial-mediated remodeling of the interhemispheric midline is required for the formation of the corpus callosum. Cell Reports, 17 3: 735-747. doi:10.1016/j.celrep.2016.09.033

  • Stringer, Brett W., Bunt, Jens, Day, Bryan W., Barry, Guy, Jamieson, Paul R., Ensbey, Kathleen S., Bruce, Zara C., Goasdoué, Kate, Vidal, Helene, Charmsaz, Sara, Smith, Fiona M., Cooper, Leanne T., Piper, Michael, Boyd, Andrew W. and Richards, Linda J. (2016) Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma. Oncotarget, 7 20: 29306-12320. doi:10.18632/oncotarget.8720

  • Tsuyama, Jun, Bunt, Jens, Richards, Linda J., Iwanari, Hiroko, Mochizuki, Yasuhiro, Hamakubo, Takao, Shimazaki, Takuya and Okano, Hideyuki (2015) MicroRNA-153 regulates the acquisition of gliogenic competence by neural stem cells. Stem Cell Reports, 5 3: 365-377. doi:10.1016/j.stemcr.2015.06.006

  • Lim, Jonathan W. C., Donahoo, Amber-Lee S., Bunt, Jens, Edwards, Timothy J., Fenlon, Laura R., Liu, Ying, Zhou, Jing, Moldrich, Randal X., Piper, Michael, Gobius, Ilan, Bailey, Timothy L., Wray, Naomi R., Kessaris, Nicoletta, Poo, Mu-Ming, Rubenstein, John L. R. and Richards, Linda J. (2015) EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex. Development, 142 21: 3746-3757. doi:10.1242/dev.119909

  • Bunt, Jens, Lim, Jonathan W., Zhao, Lu, Mason, Sharon and Richards, Linda J. (2015) PAX6 does not regulate Nfia and Nfib expression during neocortical development. Scientific Reports, 5 Art No.: 10668: . doi:10.1038/srep10668

  • Hovestadt, Volker, Jones, David T. W., Picelli, Simone, Wang, Wei, Kool, Marcel, Northcott, Paul A., Sultan, Marc, Stachurski, Katharina, Ryzhova, Marina, Warnatz, Hans-Jorg, Ralser, Meryem, Brun, Sonja, Bunt, Jens, Jager, Natalie, Kleinheinz, Kortine, Erkek, Serap, Weber, Ursula D., Bartholomae, Cynthia C., von Kalle, Christof, Lawerenz, Chris, Eils, Jurgen, Koster, Jan, Versteeg, Rogier, Milde, Till, Witt, Olaf, Schmidt, Sabine, Wolf, Stephan, Pietsch, Torsten, Rutkowski, Stefan, Scheurlen, Wolfram, Taylor, Michael D., Brors, Benedikt, Felsberg, Jorg, Reifenberger, Guido, Borkhardt, Arndt, Lehrach, Hans, Wechsler-Reya, Robert J., Eils, Roland, Yaspo, Marie-Laure, Landgraf, Pablo, Korshunov, Andrey, Zapatka, Marc, Radlwimmer, Bernhard, Pfister, Stefan M. and Lichter, Peter (2014) Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature, 510 7506: 537-541. doi:10.1038/nature13268

  • Schoenmakers, Eric F. P. M, Bunt, Jens, Hermers, Lianne, Schepens, Marga, Merkx, Gerard, Janssen, Bert, Kersten, Monique, Huys, Erik, Pauwels, Patrick, Debiec-Rychter, Maria and van Kessel, Ad Geurts (2013) Identification of CUX1 as the recurrent chromosomal band 7q22 target gene in human uterine leiomyoma. Genes Chromosomes and Cancer, 52 1: 11-23. doi:10.1002/gcc.22001

  • Bunt, Jens, Hasselt, Nancy A., Zwijnenburg, Danny A., Koster, Jan, Versteeg, Rogier and Kool, Marcel (2013) OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels. Acta Neuropathologica, 125 3: 385-394. doi:10.1007/s00401-012-1069-2

  • Bunt, J., Hasselt, N. E., Zwijnenburg, D. A., Hamdi, M., Koster, J., Versteeg, R. and Kool, M. (2012) OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells. International Journal of Cancer, 131 2: E21-E32. doi:10.1002/ijc.26474

  • Bunt, Jens, Hasselt, Nancy E., Zwijnenburg, Danny A., Koster, Jan, Versteeg, Rogier and Kool, Marcel (2011) Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma. PloS One, 6 10: e26058.1-e26058.9. doi:10.1371/journal.pone.0026058

  • Bunt, Jens, de Haas, Talitha G., Hasselt, Nancy E., Zwijnenburg, Danny A., Koster, Jan, Versteeg, Rogier and Kool, Marcel (2010) Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines. Molecular Cancer Research, 8 10: 1344-1357. doi:10.1158/1541-7786.MCR-09-0546

  • Kool, Marcel, Koster, Jan, Bunt, Jens, Hasselt, Nancy E., Lakeman, Arjan, van Sluis, Peter, Troost, Dirk, Schouten-van Meeteren, Netteke, Caron, Huib N., Cloos, Jacqueline, Mrsic, Alan, Ylstra, Bauke, Grajkowska, Wieslawa, Hartmann, Wolfgang, Pietsch, Torsten, Ellison, David, Clifford, Steven C. and Versteeg, Rogier (2008) Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PloS One, 3 8: e3088.1-e3088.14. doi:10.1371/journal.pone.0003088

Conference Publication

  • Pajtler, Kristian, Wei, Yiju, Okonechniov, Konstantin, Vouri, Mikaella, Sahm, Felix, Bunt, Jens, Jones, David, Korshunov, Andrey, Lichter, Peter, Pfister, Stefan, Kool, Marcel, Li, Wei and Kawauchi, Daisuke (2019). YAP1 subgroup supratentorial ependymoma requires tead and nuclear factor I-mediated transcriptional programs for tumorigenesis. In: 5th Biennial Conference of the Society-for-Neuro-Oncology on Pediatric Neuro-Oncology Basic and Translational Research, San Francisco, CA United States, (78-78). 3-4 May 2019. doi:10.1093/neuonc/noz036.063

  • Lambo, Sander, Bunt, Jens, Schmidt, Christine, Pfister, Stefan M., Richards, Linda J., Chavez, Lukas, Korshunov, Andrey and Kool, Marcel (2016). Genome-Wide Profiling of Embryonal Tumors with Multilayered Rosettes (Etmr). In: 17th International Symposium on Pediatric Neuro-Oncology (ISPNO), Liverpool, England, (9-9). Jun 12-15, 2016. doi:10.1093/neuonc/now067.10

  • Lambo, Sander, Bunt, Jens, Schmidt, Christine, Pfister, Stefan M., Richards, Linda J., Chavez, Lukas, Korshunov, Andrey and Kool, Marcel (2016). PNR-12Genome-wide profiling of embryonal tumors with multilayered rosettes (ETMR). In: 17th International Symposium on Pediatric Neuro-Oncology (ISPNO), Liverpool, United Kingdom, (). June 12 - 15, 2016. doi:10.1093/neuonc/now067.10

  • Gobius, I., Morcom, L., Suarez, R., Bunt, J., Sherr, E. and Richards, L. (2015). Astroglial-mediated remodeling of the interhemispheric midline is exclusive to eutherian mammals and underlies the formation of the corpus callosum. In: Supplement: GLIA Bilbao 2015: Abstracts Oral Presentations, Posters, Indexes. 12th European Meeting on Glial Cell Function in Health and Disease, Bilbao, Spain, (E206-E206). 15-18 July 2015. doi:10.1002/glia.22870

  • Gobius, I., Morcom, L., Suarez, R., Bunt, J., Sherr, E. H. and Richards, L. J. (2015). Astroglial-mediated remodeling of the interhemispheric midline underlies the formation of the corpus callosum in eutherian mammals. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (104-104). 23-27 August 2015. doi:10.1111/jnc.13188

  • Bunt, J., Hasselt, N., Koster, J., Zwijnenburg, D., Versteeg, R. and Kool, M. (2010). Otx2 Regulates Cell Cycle Genes in Medulloblastoma. In: Neuro-Oncology. 14th International Symposium on Pediatric Neuro-Oncology, Vienna Austria, (II53-II54). Jun 20-23, 2010.

PhD and MPhil Supervision

Note for students: Dr Jens Bunt is not currently available to take on new students.

Current Supervision

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

Completed Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

Dr Jens Bunt is not currently available to take on new students.

  • As I am moving to a new laboratory, I will not be taking on new student. If you are interested in neurodevelopment and disorders, go and visit the website of the Brain Development and Disorders lab contact or contact Prof. Linda Richards.

  • As I am moving to a new laboratory, I will not be taking on new student in Brisbane. If you are interested in neuro-oncology, go and visit the websites of the following UQ researchers:

    - Dr Zachery Houston (http://researchers.uq.edu.au/researcher/10273)

    - Dr Roberta Mazzieri (https://researchers.uq.edu.au/researcher/2763)

    - Dr Laura Genovesi (http://researchers.uq.edu.au/researcher/2786)

    Otherwise, if you want to come to the Netherlands, feel free to contact me.