Professor Juergen Goetz

Director of CJCADR - GL

Queensland Brain Institute

Overview

Professor Jürgen Götz is Foundation Chair of Dementia Research and Director of the Clem Jones Centre for Ageing Dementia Research at the Queensland Brain Institute (University of Queensland). He performed undergraduate studies at the Biocenter of the University of Basel, before joining the laboratory of Nobel Laureate Georges Köhler to obtain his PhD degree in immunology. Subsequently, he took up postdoctoral positions at UCSF (San Francisco) and Sandoz Ltd (now Novartis, Basel), and worked as Research Group Leader (venia legendi, Dr. habil.) at the University of Zurich (Switzerland). Before taking up his current position, Götz was a Professor and Chair of Molecular Biology at the University of Sydney. Götz is an expert in basic research in Alzheimer’s disease (AD), focusing on the cellular and molecular mechanisms of how tau and Aβ cause neurodegeneration, using transgenic and cellular models (>200 publications, including in leading journals such as Science, Cell and Neuron (h-index 72, Google Scholar). More recently, Götz developed a non-pharmacological ultrasound-based treatment strategy that removes toxic Aβ and tau in mice and restores memory functions, presenting ultrasound as a novel treatment modality for diseases of the brain. (Aug 2020)

Research Interests

  • Alzheimer's disease
  • Transgenic modelling and pathomechanisms
  • Therapeutic ultrasound as a drug delivery tool

Research Impacts

Professor Jürgen Götz is a Fellow of the Australian Academy of Health and Medical Sciences (AAHMS). He is also a permanent EAP (expert advisory panel) member of the NHMRC National Institute for Dementia Research (NNIDR), a key element of the Australian Government’s $200 million initiative to boost dementia research.

Professor Götz is a leader in his field and a highly productive scholar, having been cited >20,000 times, with an h-index of 72 (Google Scholar). His research is published in the most prestigious research journals (Cell, Science, Science Transl Med, Neuron, PNAS & EMBO Journal), and in the most highly ranked review journals (Lancet, Nature Reviews Neuroscience, Nature Reviews Neurology, 1Nature Reviews Drug Discovery, Annual Review of Pathology, with a 7th review for Nature Reviews in preparation), and he has published three protocols (Nature Protocols). His innovative therapeutic ultrasound study (Science Translational Medicine, 2015) was highlighted in Science and in Nature Reviews Neurology and ranked #37 worldwide in Altmetric. His 2010 Cell paper was covered by two Nature journals and accompanied by an Editorial in Cell, and has already attracted ~1,500 citations. 6 of his recent publications have attracted sufficient citations to place them in the top 1% based on a highly cited threshold for the field and publication year (Web of Science): Leinenga & Götz, Science Transl Med 2015; Nisbet et al., Acta Neuropathol 2015; Ittner & Götz, Nature Rev Neurosci 2011; Ittner et al., Cell 2010; Rhein et al., PNAS 2009; Götz & Ittner, Nature Rev Neurosci 2008 (see Google Scholar: public profile).

Professor Götz serves on the following Editorial Boards: 2015-2018: Section Editor for Brain Res Bulletin, 2010–present; Academic Editor for PLoS One, 2009–present; Editor for Alzheimer’s Research & Therapy, 2009–present; Review Editor for Frontiers in Neuroscience, 2008–present; Associate Editor for the Journal of Alzheimer’s Disease, JAD.

Professor Götz regularly reviews for leading journals including Nature, Nature Neuroscience, Nature Communications, EMBO J, Brain, Theranostics and others. He is regularly involved in peer review for more than 20 grant bodies (both national and international), including the ARC, NHMRC, MRC (UK), The Wellcome Trust (UK), Deutsche Forschungsgemeinschaft, Schweizerischer Nationalfonds, The Alzheimer’s Society (UK), Alzheimer’s Association (USA), Alzheimer Forschungs Initiative (AFI, D), and Fondation Plan Alzheimer (France).

Since relocating to Australia in 2005, Prof. Götz has had continuous funding through the ARC and NHMRC schemes. He has been on an NHMRC Program grant, received an Investigator grant and received >40 mA$ to support his work, CJCADR and the ultrasound project from various funding sources.

With a growing CJCADR and the expansion of his activities in basic and translational neurosciences, involving in a collaboration many teams throughout Australia and beyond, Professor Götz continues to exhibit leadership, mentorship and the promotion of scientific knowledge in Australia.

Qualifications

  • Doctor of Natural Science, Albert Ludwig University of Freiburg

Publications

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book Chapter

Journal Article

Conference Publication

  • Lesne, Sylvain, Amar, Fatou, Sherman, Mathew, Rush, Travis, Larson, Megan, Chang, Liu, Gotz, Jurgen, Schneider, Julie, Bennett, David, Ashe, Karen and Buisson, Alain (2016). SPECIFIC ALTERATIONS OF TAU PHOSPHORYLATION AND NEURONAL SIGNALING INDUCED BY THE AMYLOID-beta OLIGOMER A beta*56. 14th International Athens/Springfield Symposium on Advances In Alzheimer Therapy, Athens, Greece, Mar 09-12, 2016. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.neurobiolaging.2016.01.117

  • Leinenga, Gerhard, Nisbet, Rebecca, Hatch, Robert, Van der Jeugd, Anneke, Evans, Harrison and Götz, Jürgen (2016). Scanning Focused Ultrasound disruption of the blood-brain barrier as an Alzheimer’s disease therapy. 5th International Symposium on Focused Ultrasound, Bethesda, MD United States, 28 August - 1 September 2016. London, United Kingdom: BioMed Central. doi: 10.1186/s40349-016-0076-5

  • Götz, Jürgen, Nisbet, Rebecca, Van der Jeugd, Ann, Evans, Harrison and Leinenga, Gerhard (2016). Scanning ultrasound as a treatment tool of proteinopathies including Alzheimer’s disease. 5th International Symposium on Focused Ultrasound, Bethesda, MD, USA, 28 August - 1 September 2016. London, United Kingdom: BioMed Central. doi: 10.1186/s40349-016-0076-5

  • Gotz, Jurgen (2016). The many facets of dementia - basic science and translational strategies. Unknown, Unknown, Unknown. HOBOKEN: WILEY-BLACKWELL.

  • Leinenga, G. and Goetz, J. (2015). Effects of scanning focused ultrasound in an Alzheimer's mouse model. 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian‐Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD, Australia, 23 - 27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.

  • Turnbull, M., Goetz, J. and Coulson, E. (2015). Neurotrophin regulation of Alzheimer's disease pathology. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

  • Goetz, J., Nisbet, R., Leinenga, G. and Van der Jeugd, A. (2015). Novel strategies to target tau and Ab toxicity. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom Publisher: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13186

  • Van der Jeugd, A., Leinenga, G., Nisbet, R. and Goetz, J. (2015). Scanning ultrasound opens blood-brain barrier and improves pathologic abnormalities and behaviour in a mouse model of Alzheimer's. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, QLD, Australia, 23 - 27 August 2015. West Sussex, United Kingdom: Wiley-Blackwell Publishing.

  • Matamales, M., Skrbis, Z., Balleine, B., Goetz, J. and Bertran-Gonzalez, J. (2015). Striatal deficits underlie conflicted patterns of action selection in ageing. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

  • Gotz, Jurgen (2011). Novel functions of the protein tau in disease. ELSEVIER IRELAND LTD. doi: 10.1016/j.neures.2011.07.111

  • Gotz, Jurgen, Lim, Yun-An, Ke, Yazi D., Eckert, Anne and Ittner, Lars M. (2010). Dissecting Toxicity of Tau and β-Amyloid. Basel, Switzerland: S. Karger AG. doi: 10.1159/000283475

  • Eckert, Anne, Schulz, Kathrin L., Rhein, Virginie and Götz, Jürgen (2010). Convergence of amyloid-β and tau pathologies on mitochondria in vivo. Humana Press. doi: 10.1007/s12035-010-8109-5

  • Goetz, J. and Ittner, L. M. (2009). Axonal transport in tau transgenic mouse models. 4th European-Society-for-Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders, Leipzig Germany, Jul 11-14, 2009. WILEY-BLACKWELL PUBLISHING, INC.

  • Schroeder, H., Goetz, J., Pilz, K., Kuhlage, S., de Vos, R. A. I., Bauer, T., Selzer, A. and Koehler, C. (2009). Neurofibrillary pathology in the brainstem of the tau mutant pR5 mouse. 9th International Conference on Alzheimers and Parkinson's Diseases (AD/PD), Prague Czech Republic, Mar 11-15, 2009. Bologna, Italy: Medimond.

  • Rhein, Virginie, Baysang, Ginette, Meier, Fides, Ozmen, Laurence, Bluethmann, Horst, Droese, Stefan, Brandt, Ulrich, Mueller-Spahn, Franz, Czech, Christian, Goetz, Jurgen and Eckert, Anne (2008). Altered mitochondrial respiration and energy metabolism in brain cells from transgenic Alzheimer's disease mice. 15th European Bioenergetic Conference, Dublin Ireland, Jul 19-24, 2008. ELSEVIER SCIENCE BV. doi: 10.1016/j.bbabio.2008.05.335

  • Gotz, J., David, D., Hoerndli, F., Ke, Y. D., Schonrock, N., Wiesner, A., Fath, T., Bokhari, L., Lim, Y.-A., Deters, N. and Ittner, L. M. (2008). Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response. Basel, Switzerland: S Karger. doi: 10.1159/000113696

  • Eckert, Anne, Hauptmann, Susanne, Scherping, Isabel, Rhein, Virginie, Muller-Spahn, Franz, Gotz, Jürgen and Muller, Walter E. (2008). Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice. Basel, Switzerland: S Karger AG. doi: 10.1159/000113689

  • Gotz J., Deters N., Doldissen A., Bokhari L., Ke Y., Wiesner A., Schonrock N. and Ittner L.M. (2007). A decade of tau transgenic animal models and beyond. doi: 10.1111/j.1750-3639.2007.00051.x

  • Rhein, V, Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Savaskan, E., Mueller-Spahn, F., Czech, C., Goetz, J. and Eckert, A. (2007). Mitochondrial failure in a transgenic mice model of Alzheimer's disease with plaques and tangles. 25th Symposium of the Arbeitsgemeinschaft-Neuropsychopharmakologie-und-Pharmakopsychiatrie, Munich, Germany, 3-6 October 2007. Stuttgart, Germany: Georg Thieme. doi: 10.1055/s-2007-991813

  • Gotz, J. (2006). Transgenic animal models of Alzheimer's disease. 19th Congress of the European-College-of-Neuropsychopharmacology, Paris France, Sep 16-20, 2006. LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1016/S0924-977X(06)70110-9

  • Pennanen, L, David, D, Hoerndli, F, Kurosinski, P, Chen, F, Schild, A, Ferrari, A, Nitsch, RM and Gotz, J (2004). Amyloid-induced neurofibrillary tangle formation addressed in vivo and in vitro. 9th International Conference on Alzheimers Disease and Related Disorders, Philadelphia Pa, Jul 17-22, 2004. ELSEVIER SCIENCE INC. doi: 10.1016/S0197-4580(04)80857-1

  • Chen, E, Schild, A, Kurosinski, P, Pennanen, L, Hoerndli, E, David, D, Ferrari, A, Nitsch, RM and Gotz, J (2003). In vivo and in vitro models of AD demonstrate a role of distinct phosphorylation sites of tau in neurofibrillary tangle formation. 16th Congress of the European-College-of-Neuropsychopharmacology, Prague Czech Republic, Sep 20-24, 2003. AMSTERDAM: ELSEVIER SCIENCE BV.

  • Chen, F., Schild, A., Kurosinski, P., Pennanen, L., Hoerndli, F., David, D., Ferrari, A., Nitsch, R.M. and Götz, J. (2003). S.03.01 In vivo and in vitro models of AD demonstrate a role of distinct phosphorylation sites of tau in neurofibrillary tangle formation. Amsterdam, Netherlands: Elsevier. doi: 10.1016/s0924-977x(03)91605-1

  • Gotz, J, Chen, F, Ferrari, A, Kurosinski, P, Schild, A, Nitsch, RM and van Dorpe, J (2002). Amyloid-induced neurofibrillary tangle formation. ELSEVIER SCIENCE INC.

  • Gotz, J, Chen, F and Nitsch, RM (2002). Interactions of beta-amyloid with the formation of neurofibrillary tangles in transgenic mice. 5th International Conference on the Progress in Alzheimers and Parkinsons Disease/9th International Catecholamine Symposium, Kyoto Japan, Mar 31-Apr 05, 2001. NEW YORK: KLUWER ACADEMIC/PLENUM PUBL.

  • Chen, F, Ferrari, A, Nitsch, RM and Gotz, J (2001). The role of beta-amyloid addressed in tau filament-forming mice. BLACKWELL SCIENCE LTD.

  • Götz, J., Barmettler, R., Ferrari, A., Goedert, M., Probst, A. and Nitsch, R. M. (2000). In vivo analysis of wild-type and FTDP-17 tau transgenic mice. New York Academy of Sciences.

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

Completed Supervision