The University of Queensland

Signatures of negative selection in the genetic architecture of human complex traits

Zeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, McRae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2018) Signatures of negative selection in the genetic architecture of human complex traits. Nature Genetics, 50 5: 746-753. doi:10.1038/s41588-018-0101-4

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

Zhu, Zhihong, Zhang, Futao, Hu, Han, Bakshi, Andrew, Robinson, Matthew R., Powell, Joseph E., Montgomery,Grant W., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2016) Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nature Genetics, 48 5: 481-487. doi:10.1038/ng.3538

Common SNPs explain a large proportion of the heritability for human height

Yang, Jian, Benyamin, Beben, McEvoy, Brian P., Gordon, Scott, Henders, Anjali K., Nyholt, Dale R., Madden, Pamela A., Heath, Andrew C., Martin, Nicholas G., Montgomery, Grant W., Goddard, Michael E. and Visscher, Peter M. (2010) Common SNPs explain a large proportion of the heritability for human height. Nature Genetics, 42 7: 565-569. doi:10.1038/ng.608

Genome-wide complex trait analysis (GCTA): methods, data analyses, and interpretations

Yang, J., Lee, (Sang) Hong, Goddard, M. E. and Visscher, Peter (2013). Genome-wide complex trait analysis (GCTA): methods, data analyses, and interpretations. In Cedric Gondro, Julius van der Werf and Ben Hayes (Ed.), Genome-Wide Association Studies and Genomic Prediction (pp. 215-236) New York, NY U.S.A.: Humana Press. doi:10.1007/978-1-62703-447-0_9

Identification of common genetic risk variants for autism spectrum disorder

Grove, Jakob, Ripke, Stephan, Als, Thomas D., Mattheisen, Manuel, Walters, Raymond K., Won, Hyejung, Pallesen, Jonatan, Agerbo, Esben, Andreassen, Ole A., Anney, Richard, Awashti, Swapnil, Belliveau, Rich, Bettella, Francesco, Buxbaum, Joseph D., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Cerrato, Felecia, Chambert, Kimberly, Christensen, Jane H., Churchhouse, Claire, Dellenvall, Karin, Demontis, Ditte, De Rubeis, Silvia, Devlin, Bernie, Djurovic, Srdjan, Dumont, Ashley L., Goldstein, Jacqueline I., Hansen, Christine S., Hauberg, Mads Engel, Hollegaard, Mads V., Hope, Sigrun, Howrigan, Daniel P., Huang, Hailiang, Hultman, Christina M., Klei, Lambertus, Maller, Julian, Martin, Joanna, Martin, Alicia R., Moran, Jennifer L., Nyegaard, Mette, Nærland, Terje, Palmer, Duncan S., Palotie, Aarno, Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, dPoterba, Timothy, Poulsen, Jesper Buchhave, Pourcain, Beate St, Qvist, Per, Rehnström, Karola, Reichenberg, Abraham, Reichert, Jennifer, Robinson, Elise B., Roeder, Kathryn, Roussos, Panos, Saemundsen, Evald, Sandin, Sven, Satterstrom, F. Kyle, Davey Smith, George, Stefansson, Hreinn, Steinberg, Stacy, Stevens, Christine R., Sullivan, Patrick F., Turley, Patrick, Walters, G. Bragi, Xu, Xinyi, Wray, Naomi R., Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R., Bryois, Julien, Buttenschøn, Henriette N., Cai, Na, Castelao, Enrique, Clarke, Toni-Kim, Coleman, Jonathan R. I., Colodro-Conde, Lucía, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Davies, Gail, Deary, Ian J., Degenhardt, Franziska, Derks, Eske M., Direk, Nese, Dolan, Conor V., Dunn, Erin C., Eley, Thalia C., Escott-Price, Valentina, Kiadeh, Farnush Farhadi Hassan, Finucane, Hilary K., Forstner, Andreas J., Frank, Josef, Gaspar, Héléna A., Gill, Michael, Goes, Fernando S., Gordon, Scott D., Hall, Lynsey S., Hansen, Thomas F., Herms, Stefan, Hickie, Ian B., Hoffmann, Per, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Ising, Marcus, Jansen, Rick, Jorgenson, Eric, Knowles, James A., Kohane, Isaac S., Kraft, Julia, Kretzschmar, Warren W., Krogh, Jesper, Kutalik, Zoltán, Li, Yihan, Lind, Penelope A., MacIntyre, Donald J., MacKinnon, Dean F., Maier, Robert M., Maier, Wolfgang, Marchini, Jonathan, Mbarek, Hamdi, McGrath, Patrick, McGuffin, Peter, Medland, Sarah E., Mehta, Divya, Middeldorp, Christel M., Mihailov, Evelin, Milaneschi, Yuri, Milani, Lili, Mondimore, Francis M., Montgomery, Grant W., Mostafavi, Sara, Mullins, Niamh, Nauck, Matthias, Ng, Bernard, Nivard, Michel G., Nyholt, Dale R., O’Reilly, Paul F., Oskarsson, Hogni, Owen, Michael J., Painter, Jodie N., Peterson, Roseann E., Pettersson, Erik, Peyrot, Wouter J., Pistis, Giorgio, Posthuma, Danielle, Quiroz, Jorge A., Rice, John P., Riley, Brien P., Rivera, Margarita, Mirza, Saira Saeed, Schoevers, Robert, Schulte, Eva C., Shen, Ling, Shi, Jianxin, Shyn, Stanley I., Sigurdsson, Engilbert, Sinnamon, Grant C. B., Smit, Johannes H., Smith, Daniel J., Streit, Fabian, Strohmaier, Jana, Tansey, Katherine E., Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A., Thorgeirsson, Thorgeir E., Traylor, Matthew, Treutlein, Jens, Trubetskoy, Vassily, Uitterlinden, André G., Umbricht, Daniel, Van der Auwera, Sandra, van Hemert, Albert M., Viktorin, Alexander, Visscher, Peter M., Wang, Yunpeng, Webb, Bradley T., Weinsheimer, Shantel Marie, Wellmann, Jürgen, Willemsen, Gonneke, Witt, Stephanie H., Wu, Yang, Xi, Hualin S., Yang, Jian, Zhang, Futao, Arolt, Volker, Baune, Bernhard T., Berger, Klaus, Boomsma, Dorret I., Cichon, Sven, Dannlowski, Udo, de Geus, E. J.C., DePaulo, J. Raymond, Domenici, Enrico, Domschke, Katharina, Esko, Tõnu, Grabe, Hans J., Hamilton, Steven P., Hayward, Caroline, Heath, Andrew C., Kendler, Kenneth S., Kloiber, Stefan, Lewis, Glyn, Li, Qingqin S., Lucae, Susanne, Madden, Pamela A. F., Magnusson, Patrik K., Martin, Nicholas G., McIntosh, Andrew M., Metspalu, Andres, Müller-Myhsok, Bertram, Nöthen, Markus M., O’Donovan, Michael C., Paciga, Sara A., Pedersen, Nancy L., Penninx, Brenda W. J. H., Perlis, Roy H., Porteous, David J., Potash, James B., Preisig, Martin, Rietschel, Marcella, Schaefer, Catherine, Schulze, Thomas G., Smoller, Jordan W., Tiemeier, Henning, Uher, Rudolf, Völzke, Henry, Weissman, Myrna M., Lewis, Cathryn M., Levinson, Douglas F., Breen, Gerome, Agee, Michelle, Alipanahi, Babak, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Furlotte, Nicholas A., Hromatka, Bethann S., Huber, Karen E., Kleinman, Aaron, Litterman, Nadia K., McIntyre, Matthew H., Mountain, Joanna L., Noblin, Elizabeth S., Northover, Carrie A. M., Pitts, Steven J., Sathirapongsasuti, J. Fah, Sazonova, Olga V., Shelton, Janie F., Shringarpure, Suyash, Tung, Joyce Y., Vacic, Vladimir, Wilson, Catherine H., Stefansson, Kari, Geschwind, Daniel H., Nordentoft, Merete, Hougaard, David M., Werge, Thomas, Mors, Ole, Mortensen, Preben Bo, Neale, Benjamin M., Daly, Mark J. and Børglum, Anders D. (2019) Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics, 51 3: 431-444. doi:10.1038/s41588-019-0344-8

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

Haworth, Simon, Shapland, Chin Yang, Hayward, Caroline, Prins, Bram P., Felix, Janine F., Medina-Gomez, Carolina, Rivadeneira, Fernando, Wang, Carol, Ahluwalia, Tarunveer S., Vrijheid, Martine, Guxens, Mònica, Sunyer, Jordi, Tachmazidou, Ioanna, Walter, Klaudia, Iotchkova, Valentina, Jackson, Andrew, Cleal, Louise, Huffmann, Jennifer, Min, Josine L., Sass, Lærke, Timmers, Paul R. H. J., Turki, Saeed Al, Anderson, Carl A., Anney, Richard, Antony, Dinu, Artigas, María Soler, Ayub, Muhammad, Bala, Senduran, Barrett, Jeffrey C., Barroso, Inês, Beales, Phil, Bentham, Jamie, Bhattacharya, Shoumo, Birney, Ewan, Blackwood, Douglas, Bobrow, Martin, Bochukova, Elena, Bolton, Patrick F., Bounds, Rebecca, Boustred, Chris, Breen, Gerome, Calissano, Mattia, Carss, Keren, Charlton, Ruth, Chatterjee, Krishna, Chen, Lu, Ciampi, Antonio, Cirak, Sebahattin, Clapham, Peter, Clement, Gail, Coates, Guy, Cocca, Massimiliano, Collier, David A., Cosgrove, Catherine, Cox, Tony, Craddock, Nick, Crooks, Lucy, Curran, Sarah, Curtis, David, Daly, Allan, Danecek, Petr, Day, Ian N. M., Day-Williams, Aaron, Dominiczak, Anna, Down, Thomas, Du, Yuanping, Dunham, Ian, Durbin, Richard, Edkins, Sarah, Ekong, Rosemary, Ellis, Peter, Evans, David M., Farooqi, I. Sadaf, Fitzpatrick, David R., Flicek, Paul, Floyd, James, Foley, A. Reghan, Franklin, Christopher S., Futema, Marta, Gallagher, Louise, Gaunt, Tom R., Geihs, Matthias, Geschwind, Daniel, Greenwood, Celia M. T., Griffin, Heather, Grozeva, Detelina, Guo, Xiaosen, Guo, Xueqin, Gurling, Hugh, Hart, Deborah, Hendricks, Audrey E., Holmans, Peter, Howie, Bryan, Huang, Jie, Huang, Liren, Hubbard, Tim, Humphries, Steve E., Hurles, Matthew E., Hysi, Pirro, Jackson, David K., Jamshidi, Yalda, Joyce, Chris, Karczewski, Konrad J., Kaye, Jane, Keane, Thomas, Kemp, John P., Kennedy, Karen, Kent, Alastair, Keogh, Julia, Khawaja, Farrah, van Kogelenberg, Margriet, Kolb-Kokocinski, Anja, Lachance, Genevieve, Langford, Cordelia, Lawson, Daniel, Lee, Irene, Lek, Monkol, Li, Rui, Li, Yingrui, Liang, Jieqin, Lin, Hong, Liu, Ryan, Lönnqvist, Jouko, Lopes, Luis R., Lopes, Margarida, MacArthur, Daniel G., Mangino, Massimo, Marchini, Jonathan, Marenne, Gaëlle, Maslen, John, Mathieson, Iain, McCarthy, Shane, McGuffin, Peter, McIntosh, Andrew M., McKechanie, Andrew G., McQuillin, Andrew, Memari, Yasin, Metrustry, Sarah, Migone, Nicola, Mitchison, Hannah M., Moayyeri, Alireza, Morris, Andrew, Morris, James, Muddyman, Dawn, Muntoni, Francesco, Northstone, Kate, O’Donovan, Michael C., O’Rahilly, Stephen, Onoufriadis, Alexandros, Oualkacha, Karim, Owen, Michael J., Palotie, Aarno, Panoutsopoulou, Kalliope, Parker, Victoria, Parr, Jeremy R., Paternoster, Lavinia, Paunio, Tiina, Payne, Felicity, Payne, Stewart J., Perry, John R. B., Pietilainen, Olli, Plagnol, Vincent, Pollitt, Rebecca C., Porteous, David J., Povey, Sue, Quail, Michael A., Quaye, Lydia, Raymond, F. Lucy, Rehnström, Karola, Richards, J. Brent, Ridout, Cheryl K., Ring, Susan, Ritchie, Graham R. S., Roberts, Nicola, Robinson, Rachel L., Savage, David B., Scambler, Peter, Schiffels, Stephan, Schmidts, Miriam, Schoenmakers, Nadia, Scott, Richard H., Semple, Robert K., Serra, Eva, Sharp, Sally I., Shaw, Adam, Shihab, Hashem A., Shin, So-Youn, Skuse, David, Small, Kerrin S., Smee, Carol, Smith, Blair H., Soranzo, Nicole, Southam, Lorraine, Spasic-Boskovic, Olivera, Spector, Timothy D., St Clair, David, Stalker, Jim, Stevens, Elizabeth, Sun, Jianping, Surdulescu, Gabriela, Suvisaari, Jaana, Syrris, Petros, Taylor, Rohan, Tian, Jing, Tobin, Martin D., Valdes, Ana M., Vandersteen, Anthony M., Vijayarangakannan, Parthiban, Visscher, Peter M., Wain, Louise V., Walters, James T. R., Wang, Guangbiao, Wang, Jun, Wang, Yu, Ward, Kirsten, Wheeler, Eleanor, Whyte, Tamieka, Williams, Hywel J., Williamson, Kathleen A., Wilson, Crispian, Wilson, Scott G., Wong, Kim, Xu, ChangJiang, Yang, Jian, Zhang, Feng, Zhang, Pingbo, Zheng, Hou-Feng, Davey Smith, George, Fisher, Simon E., Wilson, James F., Cole, Tim J., Fernandez-Orth, Dietmar, Bønnelykke, Klaus, Bisgaard, Hans, Pennell, Craig E., Jaddoe, Vincent W. V., Dedoussis, George, Timpson, Nicholas, Zeggini, Eleftheria, Vitart, Veronique and St Pourcain, Beate (2019) Low-frequency variation in TP53 has large effects on head circumference and intracranial volume. Nature Communications, 10 1: . doi:10.1038/s41467-018-07863-x

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Karlsson Linnér, Richard, Biroli, Pietro, Kong, Edward, Meddens, S. Fleur W., Wedow, Robbee, Fontana, Mark Alan, Lebreton, Maël, Tino, Stephen P., Abdellaoui, Abdel, Hammerschlag, Anke R., Nivard, Michel G., Okbay, Aysu, Rietveld, Cornelius A., Timshel, Pascal N., Trzaskowski, Maciej, Vlaming, Ronald de, Zünd, Christian L., Bao, Yanchun, Buzdugan, Laura, Caplin, Ann H., Chen, Chia-Yen, Eibich, Peter, Fontanillas, Pierre, Gonzalez, Juan R., Joshi, Peter K., Karhunen, Ville, Kleinman, Aaron, Levin, Remy Z., Lill, Christina M., Meddens, Gerardus A., Muntané, Gerard, Sanchez-Roige, Sandra, Rooij, Frank J. van, Taskesen, Erdogan, Wu, Yang, Zhang, Futao, 23and Me Research Team, eQTLgen Consortium, International Cannabis Consortium, Social Science Genetic Association Consortium, Auton, Adam, Boardman, Jason D., Clark, David W., Conlin, Andrew, Dolan, Conor C., Fischbacher, Urs, Groenen, Patrick J. F., Harris, Kathleen Mullan, Hasler, Gregor, Hofman, Albert, Ikram, Mohammad A., Jain, Sonia, Karlsson, Robert, Kessler, Ronald C., Kooyman, Maarten, MacKillop, James, Männikkö, Minna, Morcillo-Suarez, Carlos, McQueen, Matthew B., Schmidt, Klaus M., Smart, Melissa C., Sutter, Matthias, Thurik, A. Roy, Uitterlinden, André G., White, Jon, Wit, Harriet de, Yang, Jian, Bertram, Lars, Boomsma, Dorret I., Esko, Tõnu, Fehr, Ernst, Hinds, David A., Johannesson, Magnus, Kumari, Meena, Laibson, David, Magnusson, Patrik K. E., Meyer, Michelle N., Navarro, Arcadi, Palmer, Abraham A., Pers, Tune H., Schunk, Daniel, Posthuma, Danielle, Stein, Murray B., Svento, Rauli, Tiemeier, Henning, Timmers, Paul R. H. J., Turley, Patrick, Ursano, Robert J., Wagner, Gert G., Wilson, James F., Gratten, Jacob, Lee, James J., Cesarini, David, Benjamin, Daniel J., Koellinger, Philipp D. and Beauchamp, Jonathan P. (2019) Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nature Genetics, 51 2: 245-257. doi:10.1038/s41588-018-0309-3

Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes

Lakhani, Chirag M., Tierney, Braden T., Manrai, Arjun K., Yang, Jian, Visscher, Peter M. and Patel, Chirag J. (2019) Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes. Nature Genetics, 51 2: 327-334. doi:10.1038/s41588-018-0313-7

Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy

Foo, Jerome C., Streit, Fabian, Frank, Josef, Witt, Stephanie H., Treutlein, Jens, Baune, Bernhard T., Moebus, Susanne, Joeckel, Karl-Heinz, Forstner, Andreas J., Noethen, Markus M., Rietschel, Marcella, Sartorius, Alexander, Kranaster, Laura, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R., Bryois, Julien, Buttenschon, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan R. I., Colodro-Conde, Lucia, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Davies, Gail, Deary, Ian J., Degenhardt, Franziska, Derks, Eske M., Direk, Nese, Dolan, Conor V., Dunn, Erin C., Eley, Thalia C., Escott-Price, Valentina, Kiadeh, Farnush Farhadi Hassan, Finucane, Hilary K., Gaspar, Helena A., Gill, Michael, Goes, Fernando S., Gordon, Scott D., Grove, Jakob, Hall, Lynsey S., Hansen, Christine Soholm, Hansen, Thomas F., Herms, Stefan, Hickie, Ian B., Hoffmann, Per, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Hougaard, David M., Ising, Marcus, Jansen, Rick, Jones, Ian, Jones, Lisa A., Jorgenson, Eric, Knowles, James A., Kohane, Isaac S., Kraft, Julia, Kretzschmar, Warren W., Krogh, Jesper, Kutalik, Zoltan, Li, Yihan, Lind, Penelope A., MacIntyre, Donald J., MacKinnon, Dean F., Maier, Robert M., Maier, Wolfgang, Marchini, Jonathan, Mbarek, Hamdi, McGrath, Patrick, McGuffin, Peter, Medland, Sarah E., Mehta, Divya, Middeldorp, Christel M., Mihailov, Evelin, Milaneschi, Yuri, Milani, Lili, Mondimore, Francis M., Montgomery, Grant W., Mostafavi, Sara, Mullins, Niamh, Nauck, Matthias, Ng, Bernard, Nivard, Michel G., Nyholt, Dale R., O'Reilly, Paul F., Oskarsson, Hogni, Owen, Michael J., Painter, Jodie N., Pedersen, Carsten Bocker, Pedersen, Marianne Giortz, Peterson, Roseann E., Pettersson, Erik, Peyrot, Wouter J., Pistis, Giorgio, Posthuma, Danielle, Quiroz, Jorge A., Qvist, Per, Rice, John P., Riley, Brien P., Rivera, Margarita, Mirza, Saira Saeed, Schoevers, Robert, Schulte, Eva C., Shen, Ling, Shi, Jianxin, Shyn, Stanley I., Sigurdsson, Engilbert, Sinnamon, Grant C. B., Smit, Johannes H., Smith, Daniel J., Stefansson, Hreinn, Steinberg, Stacy, Strohmaier, Jana, Tansey, Katherine E., Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A., Thorgeirsson, Thorgeir E., Traylor, Matthew, Trubetskoy, Vassily, Uitterlinden, Andre G., Umbricht, Daniel, Van der Auwera, Sandra, van Hemert, Albert M., Viktorin, Alexander, Visscher, Peter M., Wang, Yunpeng, Webb, Bradley T., Weinsheimer, Shantel Marie, Wellmann, Jurgen, Willemsen, Gonneke, Wu, Yang, Xi, Hualin S., Yang, Jian, Zhang, Futao, Arolt, Volker, Berger, Klaus, Boomsma, Dorret I., Cichon, Sven, Dannlowski, Udo, de Geus, E. J. C., DePaulo, J. Raymond, Domenici, Enrico, Domschke, Katharina, Esko, Tonu, Grabe, Hans J., Hamilton, Steven P., Hayward, Caroline, Heath, Andrew C., Kendler, Kenneth S., Kloiber, Stefan, Lewis, Glyn, Li, Qingqin S., Lucae, Susanne, Madden, Pamela A. F., Magnusson, Patrik K., Martin, Nicholas G., McIntosh, Andrew M., Metspalu, Andres, Mors, Ole, Mortensen, Preben Bo, Mueller-Myhsok, Bertram, Nordentoft, Merete, O'Donovan, Michael C., Paciga, Sara A., Pedersen, Nancy L., Penninx, Brenda W. J. H., Perlis, Roy H., Porteous, David J., Potash, James B., Preisig, Martin, Schaefer, Catherine, Schulze, Thomas G., Smoller, Jordan W., Stefansson, Kari, Tiemeier, Henning, Uher, Rudolf, Voelzke, Henry, Weissman, Myrna M., Werge, Thomas, Lewis, Cathryn M., Levinson, Douglas F., Breen, Gerome, Borglum, Anders D. and Sullivan, Patrick F. (2019) Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180 1: 35-45. doi:10.1002/ajmg.b.32700

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

Pulit, Sara L., Stoneman, Charli, Morris, Andrew P., Wood, Andrew R., Glastonbury, Craig A., Tyrrell, Jessica, Yengo, Loïc, Ferreira, Teresa, Marouli, Eirini, Ji, Yingjie, Yang, Jian, Jones, Samuel, Beaumont, Robin, Croteau-Chonka, Damien C., Winkler, Thomas W., Consortium, Giant, Hattersley, Andrew T., Loos, Ruth J F, Hirschhorn, Joel N., Visscher, Peter M., Frayling, Timothy M., Yaghootkar, Hanieh and Lindgren, Cecilia M. (2019) Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. Human Molecular Genetics, 28 1: 166-174. doi:10.1093/hmg/ddy327

Dissection of genetic variation and evidence for pleiotropy in male pattern baldness

Yap, Chloe X., Sidorenko, Julia, Wu, Yang, Kemper, Kathryn E., Yang, Jian, Wray, Naomi R., Robinson, Matthew R. and Visscher, Peter M. (2018) Dissection of genetic variation and evidence for pleiotropy in male pattern baldness. Nature Communications, 9 1: 5407. doi:10.1038/s41467-018-07862-y

Identification of 55,000 replicated DNA methylation QTL

McRae, Allan F., Marioni, Riccardo E., Shah, Sonia, Yang, Jian, Powell, Joseph E., Harris, Sarah E., Gibson, Jude, Henders, Anjali K., Bowdler, Lisa, Painter, Jodie N., Murphy, Lee, Martin, Nicholas G., Starr, John M., Wray, Naomi R., Deary, Ian J., Visscher, Peter M. and Montgomery, Grant W. (2018) Identification of 55,000 replicated DNA methylation QTL. Scientific Reports, 8 1: . doi:10.1038/s41598-018-35871-w

Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

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Leveraging GWAS for complex traits to detect signatures of natural selection in humans

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Imprint of assortative mating on the human genome

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Is schizophrenia a risk factor for breast cancer?—evidence from genetic data

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Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

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Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome

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Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

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Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

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Common disease is more complex than implied by the core gene omnigenic model

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Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

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GWAS on family history of Alzheimer's disease

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Global genetic differentiation of complex traits shaped by natural selection in humans

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits

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Signatures of negative selection in the genetic architecture of human complex traits

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Narrow-sense heritability estimation of complex traits using identity-by-descent information

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Improving genetic prediction by leveraging genetic correlations among human diseases and traits

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Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

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Reply to Kardos et al.: estimation of inbreeding depression from SNP data

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Transformation of summary statistics from linear mixed model association on all-or-none traits to odds ratio

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Causal associations between risk factors and common diseases inferred from GWAS summary data

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Predictive accuracy of combined genetic and environmental risk scores

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Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese

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Partitioning phenotypic variance due to parent-of-origin effects using genomic relatedness matrices

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Inference in Psychiatry via 2-Sample Mendelian Randomization-From Association to Causal Pathway?

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Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis

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Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood

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Concepts, estimation and interpretation of SNP-based heritability

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Constraints on eQTL fine mapping in the presence of multisite local regulation of gene expression

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Detection and quantification of inbreeding depression for complex traits from SNP data

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Genotype-covariate interaction effects and the heritability of adult body mass index

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10 years of GWAS discovery: biology, function, and translation

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Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism

Sapkota, Yadav, Steinthorsdottir, Valgerdur, Morris, Andrew P., Fassbender, Amelie, Rahmioglu, Nilufer, De Vivo, Immaculata, Buring, Julie E., Zhang, Futao, Edwards, Todd L., Jones, Sarah, Dorien, O., Peterse, Danielle, Rexrode, Kathryn M., Ridker, Paul M., Schork, Andrew J., MacGregor, Stuart, Martin, Nicholas G., Becker, Christian M., Adachi, Sosuke, Yoshihara, Kosuke, Enomoto, Takayuki, Takahashi, Atsushi, Kamatani, Yoichiro, Matsuda, Koichi, Kubo, Michiaki, Thorleifsson, Gudmar, Geirsson, Reynir T., Thorsteinsdottir, Unnur, Wallace, Leanne M., Yang, Jian, Edwards, Digna R. Velez, Nyegaard, Mette, Low, Siew-Kee, Zondervan, Krina T., Missmer, Stacey A., D'Hooghe, Thomas, Montgomery, Grant W., Chasman, Daniel I., Stefansson, Kari, Tung, Joyce Y. and Nyholt, Dale R. (2017) Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism. Nature Communications, 8 15539. doi:10.1038/ncomms15539

Quantifying the mapping precision of genome-wide association studies using whole-genome sequencing data

Wu, Yang, Zheng, Zhili, Visscher, Peter M. and Yang, Jian (2017) Quantifying the mapping precision of genome-wide association studies using whole-genome sequencing data. Genome Biology, 18 1: 86. doi:10.1186/s13059-017-1216-0

Genetic signatures of high-altitude adaptation in Tibetans

Yang, Jian, Jin, Zi-Bing, Chen, Jie, Huang, Xiu-Feng, Li, Xiao-Man, Liang, Yuan-Bo, Mao, Jian-Yang, Chen, Xin, Zheng, Zhili, Bakshi, Andrew, Zheng, Dong-Dong, Zheng, Mei-Qin, Wray, Naomi R., Visscher, Peter M., Lu, Fan and Qu, Jia (2017) Genetic signatures of high-altitude adaptation in Tibetans. Proceedings of the National Academy of Sciences, 114 16: 4189-4194. doi:10.1073/pnas.1617042114

The Genetic Architecture of Gene Expression in Peripheral Blood (vol 100, pg 228, 2017)

Lloyd-Jones, Luke R., Holloway, Alexander, McRae, Allan, Yang, Jian, Small, Kerrin, Zhao, Jing, Zeng, Biao, Bakshi, Andrew, Metspalu, Andres, Dermitzakis, Manolis, Gibson, Greg, Spector, Tim, Montgomery, Grant, Esko, Tonu, Visscher, Peter M. and Powell, Joseph E. (2017) The Genetic Architecture of Gene Expression in Peripheral Blood (vol 100, pg 228, 2017). American Journal of Human Genetics, 100 2: 371-371. doi:10.1016/j.ajhg.2017.01.026

Genetic evidence of assortative mating in humans

Robinson, Matthew R., Kleinman, Aaron, Graff, Mariaelisa, Vinkhuyzen, Anna A. E., Couper, David, Miller, Michael B., Peyrot, Wouter J., Abdellaoui, Abdel, Zietsch, Brendan P., Nolte, Ilja M., van Vliet-Ostaptchouk, Jana V., Snieder, Harold, The LifeLines Cohort Study, Genetic Investigation of Anthropometric Traits (GIANT) consortium, Medland, Sarah E., Martin, Nicholas G., Magnusson, Patrik K. E., Iacono, William G., McGue, Matt, North, Kari E., Yang, Jian and Visscher, Peter M. (2017) Genetic evidence of assortative mating in humans. Nature Human Behaviour, 1 1: . doi:10.1038/s41562-016-0016

The genetic architecture of gene expression in peripheral blood

Lloyd-Jones, Luke R., Holloway, Alexander, McRae, Allan, Yang, Jian, Small, Kerrin, Zeng, Biao, Bakshi, Andrew, Metspalu, Andres, Dermitzakis, Manolis, Gibson, Greg, Spector, Tim, Montgomery, Grant, Esko, Tonu, Visscher, Peter M. and Powell, Joseph E. (2017) The genetic architecture of gene expression in peripheral blood. American Journal of Human Genetics, 100 2: 228-237. doi:10.1016/j.ajhg.2016.12.008

Autosomal genetic control of human gene expression does not differ across the sexes

Kassam, Irfahan, Lloyd-Jones, Luke, Holloway, Alexander, Small, Kerrin S., Zeng, Biao, Bakshi, Andrew, Metspalu, Andres, Gibson, Greg, Spector, Tim D., Esko, Tonu, Montgomery, Grant W., Powell, Joseph E., Yang, Jian, Visscher, Peter M. and McRae, Allan F. (2016) Autosomal genetic control of human gene expression does not differ across the sexes. Genome Biology, 17 1: 248.1-248.10. doi:10.1186/s13059-016-1111-0

Identification of miRNAs as non-invasive biomarkers for early diagnosis of lung cancers

Wang, Wenzhe, Li, Weili, Ding, Mingjian, Yuan, Haining, Yang, Jian, Meng, Wen, Jin, Er, Wang, Xiaoju and Ma, Shenglin (2016) Identification of miRNAs as non-invasive biomarkers for early diagnosis of lung cancers. Tumor Biology, 37 12: 16287-16293. doi:10.1007/s13277-016-5442-y

Assessing the genetic overlap between BMI and cognitive function

Marioni, R. E., Yang, J., Dykiert, D., Mottus, R., Campbell, A., Davies, G., Hayward, C., Porteous, D. J., Visscher, P. M. and Deary, I. J. (2016) Assessing the genetic overlap between BMI and cognitive function. Molecular Psychiatry, 21 10: 1477-1482. doi:10.1038/mp.2015.205

52 genetic loci influencing myocardial mass

van der Harst, Pim, van Setten, Jessica, Verweij, Niek, Vogler, Georg, Franke, Lude, Maurano, Matthew T., Wang, Xinchen, Mateo Leach, Irene, Eijgelsheim, Mark, Sotoodehnia, Nona, Hayward, Caroline, Sorice, Rossella, Meirelles, Osorio, Lyytikainen, Leo-Pekka, Polasek, Ozren, Tanaka, Toshiko, Arking, Dan E., Ulivi, Sheila, Trompet, Stella, Muller-Nurasyid, Martina, Smith, Albert V., Dorr, Marcus, Kerr, Kathleen F., Magnani, Jared W., Del Greco, Fabiola, Zhang, Weihua, Nolte, Ilja M., Silva, Claudia T., Padmanabhan, Sandosh, Tragante, Vinicius, Esko, Tõnu, Abecasis, Gonçalo R., Adriaens, Michiel E., Andersen, Karl, Barnett, Phil, Bis, Joshua C., Bodmer, Rolf, Buckley, Brendan M., Campbell, Harry, Cannon, Megan V., Chakravarti, Aravinda, Chen, Lin Y., Delitala, Alessandro, Devereux, Richard B., Doevendans, Pieter A., Dominiczak, Anna F., Ferrucci, Luigi, Ford, Ian, Gieger, Christian, Harris, Tamara B., Haugen, Eric, Heinig, Matthias, Hernandez, Dena G., Hillege, Hans L., Hirschhorn, Joel N., Hofman, Albert, Hubner, Norbert, Hwang, Shih-Jen, Iorio, Annamaria, Kahonen, Mika, Kellis, Manolis, Kolcic, Ivana, Kooner, Ishminder K., Kooner, Jaspal S., Kors, Jan A., Lakatta, Edward G., Lage, Kasper, Launer, Lenore J., Levy, Daniel, Lundby, Alicia, Macfarlane, Peter W., May, Dalit, Meitinger, Thomas, Metspalu, Andres, Nappo, Stefania, Naitza, Silvia, Neph, Shane, Nord, Alex S., Nutile, Teresa, Okin, Peter M., Olsen, Jesper V., Oostra, Ben A., Penninger, Josef M., Pennacchio, Len A., Pers, Tune H., Perz, Siegfried, Peters, Annette, Pinto, Yigal M., Pfeufer, Arne, Pilia, Maria Grazia, Pramstaller, Peter P., Prins, Bram P., Raitakari, Olli T., Raychaudhuri, Soumya, Rice, Ken M., Rossin, Elizabeth J., Rotter, Jerome I., Schafer, Sebastian, Schlessinger, David, Schmidt, Carsten O., Sehmi, Jobanpreet, Sillje, Herman H. W., Sinagra, Gianfranco, Sinner, Moritz F., Slowikowski, Kamil, Soliman, Elsayed Z., Spector, Timothy D., Spiering, Wilko, Stamatoyannopoulos, John A., Stolk, Ronald P., Strauch, Konstantin, Tan, Sian-Tsung, Tarasov, Kirill V., Trinh, Bosco, Uitterlinden, Andre G., van den Boogaard, Malou, van Duijn, Cornelia M., van Gilst, Wiek H., Viikari, Jorma S., Visscher, Peter M., Vitart, Veronique, Volker, Uwe, Waldenberger, Melanie, Weichenberger, Christian X., Westra, Harm-Jan, Wijmenga, Cisca, Wolffenbuttel, Bruce H., Yang, Jian, Bezzina, Connie R., Munroe, Patricia B., Snieder, Harold, Wright, Alan F., Rudan, Igor, Boyer, Laurie A., Asselbergs, Folkert W., van Veldhuisen, Dirk J., Stricker, Bruno H., Psaty, Bruce M., Ciullo, Marina, Sanna, Serena, Lehtimaki, Terho, Wilson, James F., Bandinelli, Stefania, Alonso, Alvaro, Gasparini, Paolo, Jukema, J. Wouter, Kaab, Stefan, Gudnason, Vilmundur, Felix, Stephan B., Heckbert, Susan R., de Boer, Rudolf A., Newton-Cheh, Christopher, Hicks, Andrew A., Chambers, John C., Jamshidi, Yalda, Visel, Axel, Christoffels, Vincent M., Isaacs, Aaron, Samani, Nilesh J. and de Bakker, Paul I. W. (2016) 52 genetic loci influencing myocardial mass. Journal of the American College of Cardiology, 68 13: 1435-1448. doi:10.1016/j.jacc.2016.07.729

Fast set-based association analysis using summary data from GWAS identifies novel gene loci for human complex traits

Bakshi, Andrew, Zhu, Zhihong, Vinkhuyzen, Anna A. E., Hill, W. David, Mcrae, Allan F., Visscher, Peter M. and Yang, Jian (2016) Fast set-based association analysis using summary data from GWAS identifies novel gene loci for human complex traits. Scientific Reports, 6 32894. doi:10.1038/srep32894

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

van Rheenen, Wouter, Shatunov, Aleksey, Dekker, Annelot M., McLaughlin, Russell L., Diekstra, Frank P., Pulit, Sara L., van der Spek, Rick A. A., Vosa, Urmo, de Jong, Simone, Robinson, Matthew R., Yang, Jian, Fogh, Isabella, van Doormaal, Perry T. C., Tazelaar, Gijs H. P., Koppers, Max, Blokhuis, Anna M., Sproviero, William, Jones, Ashley R., Kenna, Kevin P., van Eijk, Kristel R., Harschnitz, Oliver, Schellevis, Raymond D., Brands, William J., Medic, Jelena, Menelaou, Androniki, Vajda, Alice, Ticozzi, Nicola, Lin, Kuang, Rogelj, Boris, Vrabec, Katarina, Ravnik-Glavac, Metka, Koritnik, Blazi, Zidar, Janez, Leonardis, Lea, Groselj, Leja Dolenc, Millecamps, Stephanie, Salachas, Francois, Meininger, Vincent, de Carvalho, Mamede, Pinto, Susana, Mora, Jesus S., Rojas-Garcia, Ricardo, Polak, Meraida, Chandran, Siddharthan, Colville, Shuna, Swingler, Robert, Morrison, Karen E., Shaw, Pamela J., Hardy, John, Orrell, Richard W., Pittman, Alan, Sidle, Katie, Fratta, Pietro, Malaspina, Andrea, Topp, Simon, Petri, Susanne, Abdulla, Susanne, Drepper, Carsten, Sendtner, Michael, Meyer, Thomas, Ophoff, Roel A., Staats, Kim A., Wiedau-Pazos, Martina, Lomen-Hoerth, Catherine, Van Deerlin, Vivianna M., Trojanowski, John Q., Elman, Lauren, McCluskey, Leo, Basak, A. Nazli, Tunca, Ceren, Hamzeiy, Hamid, Parman, Yesim, Meitinger, Thomas, Lichtner, Peter, Radivojkov-Blagojevic, Milena, Andres, Christian R., Maurel, Cindy, Bensimon, Gilbert, Landwehrmeyer, Bernhard, Brice, Alexis, Payan, Christine A. M., Saker-Delye, Safaa, Duerr, Alexandra, Wood, Nicholas W., Tittmann, Lukas, Lieb, Wolfgang, Franke, Andre, Rietschel, Marcella, Cichon, Sven, Noethen, Markus M., Amouyel, Philippe, Tzourio, Christophe, Dartigues, Jean-Francois, Uitterlinden, Andre G., Rivadeneira, Fernando, Estrada, Karol, Hofman, Albert, Curtis, Charles, Blauw, Hylke M., van der Kooi, Anneke J., de Visser, Marianne, Goris, An, Weber, Markus, Shaw, Christopher E., Smith, Bradley N., Pansarasa, Orietta, Cereda, Cristina, Del Bo, Roberto, Comi, Giacomo P., D'Alfonso, Sandra, Bertolin, Cinzia, Soraru, Gianni, Mazzini, Letizia, Pensato, Viviana, Gellera, Cinzia, Tiloca, Cinzia, Ratti, Antonia, Calvo, Andrea, Moglia, Cristina, Brunetti, Maura, Arcuti, Simona, Capozzo, Rosa, Zecca, Chiara, Lunetta, Christian, Penco, Silvana, Riva, Nilo, Padovani, Alessandro, Filosto, Massimiliano, Muller, Bernard, Stuit, Robbert Jan, Blair, Ian, Zhang, Katharine, McCann, Emily P., Fifita, Jennifer A., Nicholson, Garth A., Rowe, Dominic B., Pamphlett, Roger, Kiernan, Matthew C., Grosskreutz, Julian, Witte, Otto W., Ringer, Thomas, Prell, Tino, Stubendorff, Beatrice, Kurth, Ingo, Huebner, Christian A., Leigh, P. Nigel, Casale, Federico, Chio, Adrian, Beghi, Ettore, Pupillo, Elisabetta, Tortelli, Rosanna, Logroscino, Giancarlo, Powell, John, Ludolph, Albert C., Weishaupt, Jochen H., Robberecht, Wim, Van Damme, Philip, Franke, Lude, Pers, Tune H., Brown, Robert H., Glass, Jonathan D., Landers, John E., Hardiman, Orla, Andersen, Peter M., Corcia, Philippe, Vourc'h, Patrick, Silani, Vincenzo, Wray, Naomi R., Visscher, Peter M., de Bakker, Paul I. W., van Es, Michael A., Pasterkamp, R. Jeroen, Lewis, Cathryn M., Breen, Gerome, Al-Chalabi, Ammar, van den Berg, Leonard H. and Veldink, Jan H. (2016) Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. Nature Genetics, 48 9: 1043-1048. doi:10.1038/ng.3622

Across-cohort QC analyses of GWAS summary statistics from complex traits

Chen, Guo-Bo, Lee, Sang Hong, Robinson, Matthew R., Trzaskowski, Maciej, Zhu, Zhi-Xiang, Winkler, Thomas W., Day, Felix R., Croteau-Chonka, Damien C., Wood, Andrew R., Locke, Adam E., Kutalik, Zoltán, Loos, Ruth J. F., Frayling, Timothy M., Hirschhorn, Joel N., Yang, Jian, Wray, Naomi R. and Visscher, Peter M. (2016) Across-cohort QC analyses of GWAS summary statistics from complex traits. European Journal of Human Genetics, 25 1: 137-146. doi:10.1038/ejhg.2016.106

GCTA-GREML accounts for linkage disequilibrium when estimating genetic variance from genome-wide SNPs

Yang, Jian, Lee, S. Hong, Wray, Naomi R., Goddard, Michael E. and Visscher, Peter M. (2016) GCTA-GREML accounts for linkage disequilibrium when estimating genetic variance from genome-wide SNPs. Proceedings of the National Academy of Sciences, 113 32: E4579-E4580. doi:10.1073/pnas.1602743113

Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits

Pavlides, Jennifer M. Whitehead, Zhu, Zhihong, Gratten, Jacob, Mcrae, Allan F., Wray, Naomi R. and Yang, Jian (2016) Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits. Genome Medicine, 8 1: 84. doi:10.1186/s13073-016-0338-4

A plethora of pleiotropy across complex traits

Visscher, Peter M. and Yang, Jian (2016) A plethora of pleiotropy across complex traits. Nature Genetics, 48 7: 707-708. doi:10.1038/ng.3604

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Okbay, Aysu, Baselmans, Bart M. L., De Neve, Jan-Emmanuel, Turley, Patrick, Nivard, Michel G., Fontana, Mark Alan, Meddens, S. Fleur W., Linner, Richard Karlsson, Rietveld, Cornelius A., Derringer, Jaime, Gratten, Jacob, Lee, James J., Liu, Jimmy Z., de Vlaming, Ronald, Ahluwalia, Tarunveer S., Buchwald, Jadwiga, Cavadino, Alana, Frazier-Wood, Alexis C., Furlotte, Nicholas A., Garfield, Victoria, Geisel, Marie Henrike, Gonzalez, Juan R., Haitjema, Saskia, Karlsson, Robert, van der Laan, Sander W., Ladwig, Karl-Heinz, Lahti, Jari, van der Lee, Sven J., Lind, Penelope A., Liu, Tian, Matteson, Lindsay, Mihailov, Evelin, Miller, Michael B., Minica, Camelia C., Nolte, Ilja M., Mook-Kanamori, Dennis, van der Most, Peter J., Oldmeadow, Christopher, Qian, Yong, Raitakari, Olli, Rawal, Rajesh, Realo, Anu, Rueedi, Rico, Schmidt, Borge, Smith, Albert V., Stergiakouli, Evie, Tanaka, Toshiko, Taylor, Kent, Wedenoja, Juho, Wellmann, Juergen, Westra, Harm-Jan, Willems, Sara M., Zhao, Wei, Amin, Najaf, Bakshi, Andrew, Boyle, Patricia A., Cherney, Samantha, Cox, Simon R., Davies, Gail, Davis, Oliver S. P., Ding, Jun, Direk, Nese, Eibich, Peter, Emeny, Rebecca T., Fatemifar, Ghazaleh, Faul, Jessica D., Ferrucci, Luigi, Forstner, Andreas, Gieger, Christian, Gupta, Richa, Harris, Tamara B., Harris, Juliette M., Holliday, Elizabeth G., Hottenga, Jouke-Jan, De Jager, Philip L., Kaakinen, Marika A., Kajantie, Eero, Karhunen, Ville, Kolcic, Ivana, Kumari, Meena, Launer, Lenore J., Franke, Lude, Li-Gao, Ruifang, Koini, Marisa, Loukola, Anu, Marques-Vidal, Pedro, Montgomery, Grant W., Mosing, Miriam A., Paternoster, Lavinia, Pattie, Alison, Petrovic, Katja E., Pulkki-Raback, Laura, Quaye, Lydia, Raikkonen, Katri, Rudan, Igor, Scott, Rodney J., Smith, Jennifer A., Sutin, Angelina R., Trzaskowski, Maciej, Vinkhuyzen, Anna E., Yu, Lei, Zabaneh, Delilah, Attia, John R., Bennett, David A., Berger, Klaus, Bertram, Lars, Boomsma, Dorret I., Snieder, Harold, Chang, Shun-Chiao, Cucca, Francesco, Deary, Ian J., van Duijn, Cornelia M., Eriksson, Johan G., Bultmann, Ute, de Geus, Eco J. C., Groenen, Patrick J. F., Gudnason, Vilmundur, Hansen, Torben, Hartman, Catharine A., Haworth, Claire M. A., Hayward, Caroline, Heath, Andrew C., Hinds, David A., Hypponen, Elina, Iacono, William G., Jarvelin, Marjo-Riitta, Jockel, Karl-Heinz, Kaprio, Jaakko, Kardia, Sharon L. R., Keltikangas-Jarvinen, Liisa, Kraft, Peter, Kubzansky, Laura D., Lehtimaki, Terho, Magnusson, Patrik K. E., Martin, Nicholas G., Mcgue, Matt, Metspalu, Andres, Mills, Melinda, de Mutsert, Renee, Oldehinkel, Albertine J., Pasterkamp, Gerard, Pedersen, Nancy L., Plomin, Robert, Polasek, Ozren, Power, Christine, Rich, Stephen S., Rosendaal, Frits R., den Ruijter, Hester M., Schlessinger, David, Schmidt, Helena, Svento, Rauli, Schmidt, Reinhold, Alizadeh, Behrooz Z., Sorensen, Thorkild I. A., Spector, Tim D., Steptoe, Andrew, Terracciano, Antonio, Thurik, A. Roy, Timpson, Nicholas J., Tiemeier, Henning, Uitterlinden, Andre G., Vollenweider, Peter, Wagner, Gert G., Weir, David R., Yang, Jian, Conley, Dalton C., Smith, George Davey, Hofman, Albert, Johannesson, Magnus, Laibson, David I., Medland, Sarah E., Meyer, Michelle N., Pickrell, Joseph K., Esko, Tonu, Krueger, Robert F., Beauchamp, Jonathan P., Koellinger, Philipp D., Benjamin, Daniel J., Bartels, Meike and Cesarini, David (2016) Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nature Genetics, 48 6: 624-633. doi:10.1038/ng.3552

Genome-wide association study identifies 74 loci associated with educational attainment

Okbay, Aysu, Beauchamp, Jonathan P., Fontana, Mark Alan, Lee, James J., Pers, Tune H., Rietveld, Cornelius A., Turley, Patrick, Chen, Guo-Bo, Emilsson, Valur, Meddens, S. Fleur W., Oskarsson, Sven, Pickrell, Joseph K., Thom, Kevin, Timshel, Pascal, de Vlaming, Ronald, Abdellaoui, Abdel, Ahluwalia, Tarunveer S., Bacelis, Jonas, Baumbach, Clemens, Bjornsdottir, Gyda, Brandsma, Johannes H., Concas, Maria Pina, Derringer, Jaime, Furlotte, Nicholas A., Galesloot, Tessel E., Girotto, Giorgia, Gupta, Richa, Hall, Leanne M., Harris, Sarah E., Hofer, Edith, Horikoshi, Momoko, Huffman, Jennifer E., Kaasik, Kadri, Kalafati, Ioanna P., Karlsson, Robert, Kong, Augustine, Lahti, Jari, van der Lee, Sven J., de Leeuw, Christiaan, Lind, Penelope A., Lindgren, Karl-Oskar, Liu, Tian, Mangino, Massimo, Marten, Jonathan, Mihailov, Evelin, Miller, Michael B., van der Most, Peter J., Oldmeadow, Christopher, Payton, Antony, Pervjakova, Natalia, Peyrot, Wouter J., Qian, Yong, Raitakari, Olli, Rueedi, Rico, Salvi, Erika, Schmidt, Brge, Schraut, Katharina E., Shi, Jianxin, Smith, Albert V., Poot, Raymond A., St Pourcain, Beate, Teumer, Alexander, Thorleifsson, Gudmar, Verweij, Niek, Vuckovic, Dragana, Wellmann, Juergen, Westra, Harm-Jan, Yang, Jingyun, Zhao, Wei, Zhu, Zhihong, Alizadeh, Behrooz Z., Amin, Najaf, Bakshi, Andrew, Baumeister, Sebastian E., Biino, Ginevra, Bonnelykke, Klaus, Boyle, Patricia A., Campbell, Harry, Cappuccio, Francesco P., Davies, Gail, De Neve, Jan-Emmanuel, Deloukas, Panos, Demuth, Ilja, Ding, Jun, Eibich, Peter, Eisele, Lewin, Eklund, Niina, Evans, David M., Faul, Jessica D., Feitosa, Mary F., Forstner, Andreas J., Gandin, Ilaria, Gunnarsson, Bjarni, Halldorsson, Bjarni V., Harris, Tamara B., Heath, Andrew C., Hocking, Lynne J., Holliday, Elizabeth G., Homuth, Georg, Horan, Michael A., Hottenga, Jouke-Jan, de Jager, Philip L., Joshi, Peter K., Jugessur, Astanand, Kaakinen, Marika A., Kahonen, Mika, Kanoni, Stavroula, Keltigangas-Jarvinen, Liisa, Kiemeney, Lambertus A. L. M., Kolcic, Ivana, Koskinen, Seppo, Kraja, Aldi T., Kroh, Martin, Kutalik, Zoltan, Latvala, Antti, Launer, Lenore J., Lebreton, Mael P., Levinson, Douglas F., Lichtenstein, Paul, Lichtner, Peter, Liewald, David C. M., Loukola, Anu, Madden, Pamela A., Magi, Reedik, Maki-Opas, Tomi, Marioni, Riccardo E., Marques-Vidal, Pedro, Meddens, Gerardus A., McMahon, George, Meisinger, Christa, Meitinger, Thomas, Milaneschi, Yusplitri, Milani, Lili, Montgomery, Grant W., Myhre, Ronny, Nelson, Christopher P., Nyholt, Dale R., Ollier, William E. R., Palotie, Aarno, Paternoster, Lavinia, Pedersen, Nancy L., Petrovic, Katja E., Porteous, David J., Raikkonen, Katri, Ring, Susan M., Robino, Antonietta, Rostapshova, Olga, Rudan, Igor, Rustichini, Aldo, Salomaa, Veikko, Sanders, Alan R., Sarin, Antti-Pekka, Schmidt, Helena, Scott, Rodney J., Smith, Blair H., Smith, Jennifer A., Staessen, Jan A., Steinhagen-Thiessen, Elisabeth, Strauch, Konstantin, Terracciano, Antonio, Tobin, Martin D., Ulivi, Sheila, Vaccargiu, Simona, Quaye, Lydia, van Rooij, Frank J. A., Venturini, Cristina, Vinkhuyzen, Anna A. E., Volker, Uwe, Volzke, Henry, Vonk, Judith M., Vozzi, Diego, Waage, Johannes, Ware, Erin B., Willemsen, Gonneke, Attia, John R., Bennett, David A., Berger, Klaus, Bertram, Lars, Bisgaard, Hans, Boomsma, Dorret I., Borecki, Ingrid B., Bultmann, Ute, Chabris, Christopher F., Cucca, Francesco, Cusi, Daniele, Deary, Ian J., Dedoussis, George V., van Duijn, Cornelia M., Eriksson, Johan G., Franke, Barbara, Franke, Lude, Gasparini, Paolo, Gejman, Pablo V., Gieger, Christian, Grabe, Hans-Jorgen, Gratten, Jacob, Groenen, Patrick J. F., Gudnason, Vilmundur, van der Harst, Pim, Hayward, Caroline, Hinds, David A., Hoffmann, Wolfgang, Hyppnen, Elina, Iacono, William G., Jacobsson, Bo, Jarvelin, Marjo-Riitta, Jockel, Karl-Heinz, Kaprio, Jaakko, Kardia, Sharon L. R., Lehtimaki, Terho, Lehrer, Steven F., Magnusson, Patrik K. E., Martin, Nicholas G., McGue, Matt, Metspalu, Andres, Pendleton, Neil, Penninx, Brenda W. J. H., Perola, Markus, Pirastu, Nicola, Pirastu, Mario, Polasek, Ozren, Posthuma, Danielle, Power, Christine, Province, Michael A., Samani, Nilesh J., Schlessinger, David, Schmidt, Reinhold, Sorensen, Thorkild I. A., Spector, Tim D., Stefansson, Kari, Thorsteinsdottir, Unnur, Thurik, A. Roy, Timpson, Nicholas J., Tiemeier, Henning, Tung, Joyce Y., Uitterlinden, Andre G., Vitart, Veronique, Vollenweider, Peter, Weir, David R., Wilson, James F., Wright, Alan F., Conley, Dalton C., Krueger, Robert F., Smith, George Davey, Hofman, Albert, Laibson, David I., Medland, Sarah E., Meyer, Michelle N., Yang, Jian, Johannesson, Magnus, Visscher, Peter M., Esko, Tonu, Koellinger, Philipp D., Cesarini, David and Benjamin, Daniel J. (2016) Genome-wide association study identifies 74 loci associated with educational attainment. Nature, 533 7604: 539-542. doi:10.1038/nature17671

Evidence for genetic overlap between schizophrenia and age at first birth in women

Mehta, Divya, Tropf, Felix C., Gratten, Jacob, Bakshi, Andrew, Zhu, Zhihong, Bacanu, Silviu-Alin, Hemani, Gibran, Magnusson, Patrik K. E., Barban, Nicola, Esko, Tonu, Metspalu, Andres, Snieder, Harold, Mowry, Bryan J., Kendler, Kenneth S., Yang, Jian, Visscher, Peter M., McGrath, John J., Mills, Melinda C., Wray, Naomi R. and Lee, S. Hong (2016) Evidence for genetic overlap between schizophrenia and age at first birth in women. Jama Psychiatry, 73 5: 497-505. doi:10.1001/jamapsychiatry.2016.0129

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

Zhu, Zhihong, Zhang, Futao, Hu, Han, Bakshi, Andrew, Robinson, Matthew R., Powell, Joseph E., Montgomery,Grant W., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2016) Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nature Genetics, 48 5: 481-487. doi:10.1038/ng.3538

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

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Genome-wide genetic homogeneity between sexes and populations for human height and body mass index

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The transcriptional landscape of age in human peripheral blood

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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

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The UK10K project identifies rare variants in health and disease

The UK10K Consortium, Evans, David M., Kemp, John P., Visscher, Peter M. and Yang, Jian (2015) The UK10K project identifies rare variants in health and disease. Nature, 526 7571: 82-89. doi:10.1038/nature14962

The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study

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Population genetic differentiation of height and body mass index across Europe

Robinson, Matthew R., Hemani, Gibran, Medina-Gomez, Carolina, Mezzavilla, Massimo, Esko, Tonu, Shakhbazov, Konstantin, Powell, Joseph E., Vinkhuyzen, Anna, Berndt, Sonja I., Gustafsson, Stefan, Justice, Anne E., Kahali, Bratati, Locke, Adam E., Pers, Tune H., Vedantam, Sailaja, Wood, Andrew R., van Rheenen, Wouter, Andreassen, Ole A., Gasparini, Paolo, Metspalu, Andres, van den Berg, Leonard H., Veldink, Jan H., Rivadeneira, Fernando, Werge, Thomas M., Abecasis, Goncalo R., Boomsma, Dorret I., Chasman, Daniel I., de Geus, Eco J. C., Frayling, Timothy M., Hirschhorn, Joel N., Hottenga, Jouke Jan, Ingelsson, Erik, Loos, Ruth J. F., Magnusson, Patrik K. E., Martin, Nicholas G., Montgomery, Grant W., North, Kari E., Pedersen, Nancy L., Spector, Timothy D., Speliotes, Elizabeth K., Goddard, Michael E., Yang, Jian and Visscher, Peter M. (2015) Population genetic differentiation of height and body mass index across Europe. Nature Genetics, 47 11: 1357-1361. doi:10.1038/ng.3401

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

Yang, Jian, Bakshi, Andrew, Zhu, Zhihong, Hemani, Gibran, Vinkhuyzen, Anna A. E., Lee, Sang Hong, Robinson, Matthew R., Perry, John R. B., Nolte, Ilja M., van Vliet-Ostaptchouk, Jana V., Snieder, Harold, The LifeLines Cohort Study, Esko, Tonu, Milani, Lili, Maegi, Reedik, Metspalu, Andres, Hamsten, Anders, Magnusson, Patrik K. E., Pedersen, Nancy L., Ingelsson, Erik, Soranzo, Nicole, Keller, Matthew C., Wray, Naomi R., Goddard, Michael E. and Visscher, Peter M. (2015) Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nature Genetics, 47 10: 1114-1120. doi:10.1038/ng.3390

Improving phenotypic prediction by combining genetic and epigenetic associations

Shah, Sonia, Bonder, Marc J., Marioni, Riccardo E., Zhu, Zhihong, McRae, Allan F., Zhernakova, Alexandra, Harris, Sarah E., Liewald, Dave, Henders, Anjali K., Mendelson, Michael M., Liu, Chunyu, Joehanes, Roby, Liang, Liming, Levy, Daniel, Martin, Nicholas G., Starr, John M., Wijmenga, Cisca, Wray, Naomi R., Yang, Jian, Montgomery, Grant W., Franke, Luke, Deary, Ian J., Visscher, Peter M. and BIOS Consortium (2015) Improving phenotypic prediction by combining genetic and epigenetic associations. American Journal of Human Genetics, 97 1: 75-85. doi:10.1016/j.ajhg.2015.05.014

Human fertility, molecular genetics, and natural selection in modern societies

Tropf, Felix C., Stulp, Gert, Barban, Nicola, Visscher, Peter M., Yang, Jian, Snieder, Harold and Mills, Melinda C. (2015) Human fertility, molecular genetics, and natural selection in modern societies. Plos One, 10 6: 1-14. doi:10.1371/journal.pone.0126821

Mendelian randomization study of height and risk of colorectal cancer

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Mixed model with correction for case-control ascertainment increases association power

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Whole-genome sequence-based analysis of thyroid function

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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

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Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits

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New genetic loci link adipose and insulin biology to body fat distribution

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Biological interpretation of genome-wide association studies using predicted gene functions

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Mixed model approaches for detecting influential observations in genetic data analysis

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Replicability and robustness of genome-wide-association studies for behavioral traits

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Another explanation for apparent epistasis: reply

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Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease

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A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans

Timpson, Nicholas J., Walter, Klaudia, Min, Josine L., Tachmazidou, Ioanna, Malerba, Giovanni, Shin, So-Youn, Chen, Lu, Futema, Marta, Southam, Lorraine, Iotchkova, Valentina, Cocca, Massimiliano, Huang, Jie, Memari, Yasin, McCarthy, Shane, Danecek, Petr, Muddyman, Dawn, Mangino, Massimo, Menni, Cristina, Perry, John R. B., Ring, Susan M., Gaye, Amadou, Dedoussis, George, Farmaki, Aliki-Eleni, Burton, Paul, Talmud, Philippa J., Gambaro, Giovanni, Spector, Tim D., Smith, George Davey, Durbin, Richard, Richards, J. Brent, Humphries, Steve E., Zeggini, Eleftheria, Soranzo, Nicole, UK10K Consortium, Evans, David, Kemp, John, Visscher, Peter M. and Yang, Jian (2014) A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans. Nature Communications, 5 1: 1-10. doi:10.1038/ncomms5871

The genetic architecture of pediatric cognitive abilities in the Philadelphia Neurodevelopmental Cohort

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Erratum: Incorrect Institutional Affiliations of Authors in the Article by Jiang et al (Arthritis Rheumatol (2014))

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Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis

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DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12

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Detection and replication of epistasis influencing transcription in humans

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Advantages and pitfalls in the application of mixed-model association methods

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Childhood intelligence is heritable, highly polygenic and associated with FNBP1L

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Genetics of rheumatoid arthritis contributes to biology and drug discovery

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Novel risk loci for rheumatoid arthritis in han chinese and congruence with risk variants in europeans

Jiang, Lei, Yin, Jian, Ye, Lingying, Yang, Jian, Hemani, Gibran, Liu, Ai-Jun, Zou, Hejian, He, Dongyi, Sun, Lingyun, Zeng, Xiaofeng, Li, Zhanguo, Zheng Yi, Lin, Yiping, Liu, Yi, Fang, Yongfei, Xu, Jianhua, Li, Yinong, Dai, Shengming, Guan, Jianlong, Jiang, Lindi, Wei, Qianghua, Wang, Yi, Li, Yang, Huang, Cibo, Zuo, Xiaoxia, Liu, Yu, Wu, Xin, Zhang, Libin, Zhou, Ling, Zhang, Qing, Li, Ting, Chen, Ling, Xu, Zhen, Yang, Xiaoping, Qian, Feng, Xie, Weilin, Liu Wei, Guo, Qian, Huang, Weilin, Zhao, Jing, Li, Mengmeng, Jin, Yanhua, Gao, Jie, Lv, Yeng, Wang, Yiwen, Lin, Li, Guo, Aihua, Danoy, Patrick, Willner, Dana, Cremin, Catherine, Hadler, Johanna, Zhang, Fengchun, Zhao, Yan, Li, Mengtao, Yue, Tao, Fan, Xiaolei, Guo, Jianping, Mu, Rong, Li, Jingyi, Wu, Chao, Zeng, Ming, Wang, Jiucun, Li, Shilin, Jin, Li, Wang, Binbin, Wang, Jing, Ma, Xu, Sun, Liangdan, Zhang, Xuejun, Brown, Matthew A., Visscher, Peter M., Su, Ding-feng and Xu, Huji (2014) Novel risk loci for rheumatoid arthritis in han chinese and congruence with risk variants in europeans. Arthritis and Rheumatology, 66 5: 1121-1132. doi:10.1002/art.38353

Statistical Power to Detect Genetic (Co)Variance of Complex Traits Using SNP Data in Unrelated Samples

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Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs

Hemani, Gibran, Yang, Jian, Vinkhuyzen, Anna, Powell, Joseph E., Willemsen, Gonneke, Hottenga, Jouke-Jan, Abdellaoui, Abdel, Mangino, Massimo, Valdes, Ana M., Medland, Sarah E., Madden, Pamela A., Heath, Andrew C., Henders, Anjali K., Nyholt, Dale R., de Geus, Eco J. C., Magnusson, Patrik K. E., Ingelsson, Erik, Montgomery, Grant W., Spector, Timothy D., Boomsma, Dorret I., Pedersen, Nancy L., Martin, Nicholas G. and Visscher, Peter M. (2013) Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs. American Journal of Human Genetics, 93 5: 865-875. doi:10.1016/j.ajhg.2013.10.005

Response to 'Predicting the diagnosis of autism spectrum disorder using gene pathway analysis'

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FTO gene, obesity and colon cancer: from epidemiological evidence to laboratory studies

Chen, Jiezhong, Yang, Jian and Zhao, Kong-Nan (2013) FTO gene, obesity and colon cancer: from epidemiological evidence to laboratory studies. Translational Gastrointestinal Cancer, 2 4: 194-203. doi:10.3978/j.issn.2224-4778.2013.10.02

Additive genetic variation in schizophrenia risk is shared by populations of African and European descent

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DNA evidence for strong genome-wide pleiotropy of cognitive and learning abilities

Trzaskowski, Maciej, Davis, Oliver S. P., DeFries, John C., Yang, Jian, Visscher, Peter M. and Plomin, Robert (2013) DNA evidence for strong genome-wide pleiotropy of cognitive and learning abilities. Behavior Genetics, 43 4: 267-273. doi:10.1007/s10519-013-9594-x

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

Cortes, Adrian, Hadler, Johanna, Pointon, Jenny P., Robinson, Philip C., Karaderi, Tugce, Leo, Paul, Cremin, Katie, Pryce, Karena, Harris, Jessica, Lee, Seunghun, Joo, Kyung Bin, Shim, Seung-Cheol, Weisman, Michael, Ward, Michael, Zhou, Xiaodong, Garchon, Henri-Jean, Chiocchia, Gilles, Nossent, Johannes, Lie, Benedicte A., Førre, Øystein, Tuomilehto, Jaakko, Laiho, Kari, Jiang, Lei, Liu, Yu, Wu, Xin, Bradbury, Linda A., Elewaut, Dirk, Burgos-Vargas, Ruben, Stebbings, Simon, Appleton, Louise, Farrah, Claire, Lau, Jonathan, Kenna, Tony J., Haroon, Nigil, Ferreira, Manuel A., Yang, Jian, Mulero, Juan, Fernandez-Sueiro, Jose Luis, Gonzalez-Gay, Miguel A., Lopez-Larrea, Carlos, Deloukas, Panos, Donnelly, Peter, Bowness, Paul, Gafney, Karl, Gaston, Hill, Gladman, Dafna D., Rahman, Proton, Maksymowych, Walter P., Xu, Huji, Crusius, J. Bart A., van der Horst-Bruinsma, Irene E., Chou, Chung-Tei, Valle-Oñate, Raphael, Romero-Sánchez, Consuelo, Hansen, Inger Myrnes, Pimentel-Santos, Fernando M., Inman, Robert D., Videm, Vibeke, Martin, Javier, Breban, Maxime, Reveille, John D., Evans, David M., Kim, Tae-Hwan, Wordsworth, Bryan Paul, Brown, Matthew A., Australo-Anglo-American Spondyloarthritis Consortium (TASC), Groupe Française d?Etude Génétique des Spondylarthrites (GFEGS), Nord-Trøndelag Health Study (HUNT), Spondyloarthritis Research Consortium of Canada (SPARCC) and Wellcome Trust Case Control Consortium 2 (WTCCC2) (2013) Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nature Genetics, 45 7: 730-740. doi:10.1038/ng.2667

Pitfalls of predicting complex traits from SNPs

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GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

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Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

den Hoed, Marcel, Eijgelsheim, Mark, Esko, Tonu, Brundel, Bianca J. J. M., Peal, David S., Evans, David M., Nolte, Ilja M., Segre, Ayellet V., Holm, Hilma, Handsaker, Robert E., Westra, Harm-Jan, Johnson, Toby, Isaacs, Aaron, Yang, Jian, Lundby, Alicia, Zhao, Jing Hua, Kim, Young Jin, Go, Min Jin, Almgren, Peter, Bochud, Murielle, Boucher, Gabrielle, Cornelis, Marilyn C., Gudbjartsson, Daniel, Hadley, David, van der Harst, Pim, Hayward, Caroline, den Heijer, Martin, Igl, Wilmar, Jackson, Anne U., Kutalik, Zoltan, Luan, Jian'an, Kemp, John P., Kristiansson, Kati, Ladenvall, Claes, Lorentzon, Mattias, Montasser, May E., Njajou, Omer T., O'Reilly, Paul F., Padmanabhan, Sandosh, Pourcain, Beate St., Rankinen, Tuomo, Salo, Perttu, Tanaka, Toshiko, Timpson, Nicholas J., Vitart, Veronique, Waite, Lindsay, Wheeler, William, Zhang, Weihua, Draisma, Harmen H. M., Feitosa, Mary F., Kerr, Kathleen F., Lind, Penelope A., Mihailov, Evelin, Onland-Moret, N. 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Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

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Mitochondrial dysfunction in a novel form of autosomal recessive ataxia

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Ubiquitous polygenicity of human complex traits: genome-wide analysis of 49 traits in Koreans

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Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus

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Estimation of SNP heritability from dense genotype data

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Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

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Seventy-five genetic loci influencing the human red blood cell

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Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood

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FTO genotype is associated with phenotypic variability of body mass index

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Evidence of inbreeding depression on human height

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Statistical method for mapping QTLs for complex traits based on two backcross populations

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Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs (vol 44, pg 247, 2012)

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Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion (vol 2, e125, 2012)

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Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion

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Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

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Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

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Genetic contributions to stability and change in intelligence from childhood to old age

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Five years of GWAS discovery

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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

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Genome-wide association studies establish that human intelligence is highly heritable and polygenic

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Response to Browning and Browning

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Genomic inflation factors under polygenic inheritance

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Genome partitioning of genetic variation for complex traits using common SNPs

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GCTA: a tool for genome-wide complex trait analysis

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A Commentary on 'Common SNPs Explain a Large Proportion of the Heritability for Human Height' by Yang et al. (2010)

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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

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From Galton to GWAS: Quantitative genetics of human height

Visscher, Peter M., McEvoy, Brian and Yang, Jian (2010) From Galton to GWAS: Quantitative genetics of human height. Genetics Research, 92 5-6: 371-379. doi:10.1017/S0016672310000571

Corrigendum to: Sporadic cases are the norm for complex disease (European Journal of Human Genetics (2010) 18 (1039-1043) DOI: 10.1038/ejhg.2009.177)

Yang, Jian, Visscher, Peter M. and Wray, Naomi R. (2010) Corrigendum to: Sporadic cases are the norm for complex disease (European Journal of Human Genetics (2010) 18 (1039-1043) DOI: 10.1038/ejhg.2009.177). European Journal of Human Genetics, 18 9: 1044-1044. doi:10.1038/ejhg.2009.233

Sporadic cases are the norm for complex disease

Yang, Jian, Visscher, Peter M. and Wray, Naomi R. (2010) Sporadic cases are the norm for complex disease. European Journal of Human Genetics, 18 9: 1039-1043. doi:10.1038/ejhg.2009.177

Common SNPs explain a large proportion of the heritability for human height

Yang, Jian, Benyamin, Beben, McEvoy, Brian P., Gordon, Scott, Henders, Anjali K., Nyholt, Dale R., Madden, Pamela A., Heath, Andrew C., Martin, Nicholas G., Montgomery, Grant W., Goddard, Michael E. and Visscher, Peter M. (2010) Common SNPs explain a large proportion of the heritability for human height. Nature Genetics, 42 7: 565-569. doi:10.1038/ng.608

QTLNetworkR: an interactive R package for QTL visualization

Zheng, Wen-jun, Yang, Jian and Zhu, Jun (2010) QTLNetworkR: an interactive R package for QTL visualization. Journal of Zhejiang University-Science B, 11 7: 512-515. doi:10.1631/jzus.B0900384

Comparing apples and oranges: Equating the power of case-control and quantitative trait association studies

Yang, Jian, Wray, Naomi R. and Visscher, Peter M. (2010) Comparing apples and oranges: Equating the power of case-control and quantitative trait association studies. Genetic Epidemiology, 34 3: 254-257. doi:10.1002/gepi.20456

The Genetic Interpretation of Area under the ROC Curve in Genomic Profiling

Wray, Naomi R., Yang, Jian, Goddard, Michael E. and Visscher, Peter M. (2010) The Genetic Interpretation of Area under the ROC Curve in Genomic Profiling. PLoS Genetics, 6 2: e1000864.1-e1000864.9. doi:10.1371/journal.pgen.1000864

Uncovering genetic regulatory network divergence between duplicate genes using yeast eQTL landscape

Zou, Yangyun, Su, Zhixi, Yang, Jian, Zeng, Yanwu and Gu, Xun (2009) Uncovering genetic regulatory network divergence between duplicate genes using yeast eQTL landscape. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 312B 7: 722-733. doi:10.1002/jez.b.21290

Identifying differentially expressed genes in human acute leukemia and mouse brain microarray datasets utilizing QTModel

Yang, Jian, Zou, Yangyun and Zhu, Jun (2009) Identifying differentially expressed genes in human acute leukemia and mouse brain microarray datasets utilizing QTModel. Functional & Integrative Genomics, 9 1: 59-66. doi:10.1007/s10142-008-0096-5

Influence of outliers on QTL mapping for complex traits

Hayat, Yousaf, Yang, Jian, Xu, Hai-ming and Zhu, Jun (2008) Influence of outliers on QTL mapping for complex traits. Journal of Zhejiang University-Science B, 9 12: 931-937. doi:10.1631/jzus.B0820045

Mapping interspecific genetic architecture in a host-parasite interaction system

Yang, Jian, Wu, Weiren and Zhu, Jun (2008) Mapping interspecific genetic architecture in a host-parasite interaction system. Genetics, 178 3: 1737-1743. doi:doi:10.1534/genetics.107.081430

QTLNetwork: mapping and visualizing genetic architecture of complex traits in experimental populations

Yang, Jian, Hu, Chengcheng, Hu, Han, Yu, Rongdong, Xia, Zhen, Ye, Xiuzi and Zhu, Jun (2008) QTLNetwork: mapping and visualizing genetic architecture of complex traits in experimental populations. Bioinformatics, 24 5: 721-723. doi:10.1093/bioinformatics/btm494

Genetic analysis of grain yield conditioned on its component traits in rice (Oryza sativa L.)

Liu, G. F., Yang, J., Xu, H. M., Hayat, Y. and Zhu, J. (2008) Genetic analysis of grain yield conditioned on its component traits in rice (Oryza sativa L.). Australian Journal of Agricultural Research, 59 2: 189-195. doi:10.1071/AR07163

Influence of Epistasis and QTL × Environment Interaction on Heading Date of Rice (Oryza sativa L.)

Liu, Guifu, Yang, Jian, Xu, Haiming and Zhu, Jun (2007) Influence of Epistasis and QTL × Environment Interaction on Heading Date of Rice (Oryza sativa L.). Journal of Genetics and Genomics, 34 7: 608-615. doi:10.1016/S1673-8527(07)60069-1

Analysis of Genetic Effects of Nuclear-Cytoplasmic Interaction on Quantitative Traits: Genetic Model for Diploid Plants

Han, Lide, Yang, Jian and Zhu, Jun (2007) Analysis of Genetic Effects of Nuclear-Cytoplasmic Interaction on Quantitative Traits: Genetic Model for Diploid Plants. Journal of Genetics and Genomics, 34 6: 562-568. doi:10.1016/S1673-8527(07)60062-9

Mapping the genetic architecture of complex traits in experimental populations

Yang, Jian, Zhu, Jun and Williams, Robert W. (2007) Mapping the genetic architecture of complex traits in experimental populations. Bioinformatics, 23 12: 1527-1536. doi:10.1093/bioinformatics/btm143

3D graphical visualization of the genetic architectures underlying complex traits in multiple environments

Hu Cheng-cheng, Ye Xiu-zi, Zhang Yin, Yu Rong-dong, Yang Jian and Zhu Jun (2007) 3D graphical visualization of the genetic architectures underlying complex traits in multiple environments. Journal of Zhejiang University-Science a, 8 4: 563-567. doi:10.1631/jzus.2007.A0563

Genetic analysis on tiller number and plant height per plant in rice (Oryza sativa L.)

Liu, Gui-Fu, Xu, Hai-Ming, Yang, Jian and Zhu, Jun (2006) Genetic analysis on tiller number and plant height per plant in rice (Oryza sativa L.). Zhejiang Daxue Xuebao (Nongye yu Shengming Kexue Ban)/Journal of the Zhejiang University - Agriculture and Life Science, 32 5: 527-534.

Mapping QTL for Biomass Yield and Its Components in Rice (Oryza sativa L.)

LIU, Gui-Fu, YANG, Jian and ZHU, Jun (2006) Mapping QTL for Biomass Yield and Its Components in Rice (Oryza sativa L.). Acta Genetica Sinica, 33 7: 607-616. doi:10.1016/S0379-4172(06)60090-5

Methods for predicting superior genotypes under multiple environments based on QTL effects

Yang, J and Zhu, J (2005) Methods for predicting superior genotypes under multiple environments based on QTL effects. Theoretical and Applied Genetics, 110 7: 1268-1274. doi:10.1007/s00122-005-1963-2

Association between population density and genetic risk for schizophrenia

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Signatures of negative selection in the genetic architecture of human complex traits

Zeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, Mcrae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2018). Signatures of negative selection in the genetic architecture of human complex traits. In: 48th Annual Meeting of the Behavior-Genetics-Association (BGA), Boston MA, United States, (525-525). 20-23 June 2018.

Evidence for genetic overlap between schizophrenia and maternal age at first birth

Mehta, Divya, Tropf, Felix, Gratten, Jacob, Bacanu, Silviu, Bakshi, Andrew, Mowry, Bryan, Kendler, Kenneth, Yang, Jian, Visscher, Peter, McGrath, John, Mills, Melinda, Wray, Naomi and Lee, Sang Hong (2017). Evidence for genetic overlap between schizophrenia and maternal age at first birth. In: 23rd Annual World Congress of Psychiatric Genetics (WCPG), Toronto, ON, Canada, (S255-S256). 16-20 October 2015. doi:10.1016/j.euroneuro.2015.09.010

Additive genetic variation in risk to schizophrenia across African American and European American populations

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Single-chip RF CMOS UMTS/EGSM transceiver with integrated receive diversity and GPS

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