Janin Chandra received her Master of Science from the University of Frankfurt/ Germany, where she investigated the impact of vaccinia virus‐induced type I interferons on specific T cell expansion. In 2011, Janin completed her HDR studies in the Department of Experimental Immunology of the University of Zurich/Switzerland under supervision of Prof. Burkhard Becher where she investigated the role of NFkB‐inducing kinase (NIK) in cell‐mediated immunity and autoimmunity. It was then that Janin specialized in antigen-presenting cells and their properties in health and disease. In 2012, Janin received a 3-year post-doctoral research fellowship to join Prof. Ian Frazer’s research team at the University of Queensland Diamantina Institute. Her studies here focussed on the role of different types of dendritic cells in human papillomavirus (HPV)-driven immune suppression. In 2015, Janin joined the team of Admedus Vaccines Pty Ltd. as Senior Scientist, a spin-off company located at the Translational Research Institute, which aims to develop immunotherapeutic vaccine strategies to combat chronic herpes-simplex 2 infections and HPV-induced malignancies. Janin managed all pre-clinical research activities within the company, and contributed to clinical trial activities. Since 2019, Janin re-joined the University of Queensland Diamantina Institute as Research Fellow, where she investigates human papillomavirus-driven immune suppression in antigen-presenting cells, and aims to optimize HPV-targeted immunotherapy approaches.
Budhwani, Megha, Turrell, Gavin, Yu, Meihua, Frazer, Ian H., Mehdi, Ahmed M. and Chandra, Janin (2021). Immune-inhibitory gene expression is positively correlated with overall immune activity and predicts increased survival probability of cervical and head and neck cancer patients. Frontiers in Molecular Biosciences, 8 622643, 622643. doi: 10.3389/fmolb.2021.622643
Journal Article: Antigen nonspecific induction of distinct regulatory T cell states in oncogene-driven hyperproliferative skin
Zhou, Chenhao, Tuong, Zewen Kelvin, Lukowski, Samuel Wieslaw, Chandra, Janin and Frazer, Ian H. (2021). Antigen nonspecific induction of distinct regulatory T cell states in oncogene-driven hyperproliferative skin. ImmunoHorizons, 5 (2), 102-116. doi: 10.4049/immunohorizons.2100006
Journal Article: Manganese-doped silica-based nanoparticles promote the efficacy of antigen-specific immunotherapy
Chandra, Janin, Teoh, Siok Min, Kuo, Paula, Tolley, Lynn, Bashaw, Abate Assefa, Tuong, Zewen Kelvin, Liu, Yang, Chen, Zibin, Wells, James W., Yu, Chengzhong, Frazer, Ian H. and Yu, Meihua (2021). Manganese-doped silica-based nanoparticles promote the efficacy of antigen-specific immunotherapy. The Journal of Immunology, 206 (5), ji2000355-998. doi: 10.4049/jimmunol.2000355
Assessment of predictors of response to checkpoint blockade
(2021) PA Research Foundation
The role of different dendritic cell subsets in the clearance of papillomavirus infection
(2012–2016) UQ Postdoctoral Research Fellowship
Understanding CD4+ T cell responses to HPV16 E7 antigen in a mouse model of precancerous skin
Doctor Philosophy
The role of bacterially induced inflammation in squamous skin cancer development
Doctor Philosophy
Modulation of Immune Responses by HPV-Induced Epithelial Hyperplasia
(2020) Doctor Philosophy
Therapeutic DNA Vaccine Against HPV16-Associated Cancer
Yu, Meihua and Chandra, Janin (2021). Therapeutic DNA Vaccine Against HPV16-Associated Cancer. DNA Vaccines. (pp. 241-252) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-0872-2_13
Budhwani, Megha, Turrell, Gavin, Yu, Meihua, Frazer, Ian H., Mehdi, Ahmed M. and Chandra, Janin (2021). Immune-inhibitory gene expression is positively correlated with overall immune activity and predicts increased survival probability of cervical and head and neck cancer patients. Frontiers in Molecular Biosciences, 8 622643, 622643. doi: 10.3389/fmolb.2021.622643
Zhou, Chenhao, Tuong, Zewen Kelvin, Lukowski, Samuel Wieslaw, Chandra, Janin and Frazer, Ian H. (2021). Antigen nonspecific induction of distinct regulatory T cell states in oncogene-driven hyperproliferative skin. ImmunoHorizons, 5 (2), 102-116. doi: 10.4049/immunohorizons.2100006
Manganese-doped silica-based nanoparticles promote the efficacy of antigen-specific immunotherapy
Chandra, Janin, Teoh, Siok Min, Kuo, Paula, Tolley, Lynn, Bashaw, Abate Assefa, Tuong, Zewen Kelvin, Liu, Yang, Chen, Zibin, Wells, James W., Yu, Chengzhong, Frazer, Ian H. and Yu, Meihua (2021). Manganese-doped silica-based nanoparticles promote the efficacy of antigen-specific immunotherapy. The Journal of Immunology, 206 (5), ji2000355-998. doi: 10.4049/jimmunol.2000355
Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium
Bashaw, Abate Assefa, Zhou, Chenhao, Yu, Meihua, Tolley, Lynn, Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2020). Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium. The Journal of Investigative Dermatology, 141 (5), 1264-1273.e3. doi: 10.1016/j.jid.2020.10.011
Chandra, J., Woo, W. P., Finlayson, N., Liu, H. Y., McGrath, M., Ladwa, R., Brauer, M., Xu, Y., Hanson, S., Panizza, B., Frazer, I. H. and Porceddu, Sandro V. (2020). A phase 1, single centre, open label, escalating dose study to assess the safety, tolerability and immunogenicity of a therapeutic human papillomavirus (HPV) DNA vaccine (AMV002) for HPV-associated head and neck cancer (HNC). Cancer Immunology, Immunotherapy, 70 (3), 743-753. doi: 10.1007/s00262-020-02720-7
Budhwani, Megha, Lukowski, Samuel W., Porceddu, Sandro V., Frazer, Ian H. and Chandra, Janin (2020). Dysregulation of stemness pathways in HPV mediated cervical malignant transformation identifies potential oncotherapy targets. Frontiers in Cellular and Infection Microbiology, 10 307, 307. doi: 10.3389/fcimb.2020.00307
Chandra, Janin, Woo, Wai-Ping, Dutton, Julie L., Xu, Yan, Li, Bo, Kinrade, Sally, Druce, Julian, Finlayson, Neil, Griffin, Paul, Laing, Kerry J., Koelle, David M. and Frazer, Ian H. (2019). Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: a randomized double blinded phase I/IIa trial. PLoS One, 14 (12) e0226320, 1-20. doi: 10.1371/journal.pone.0226320
Immunotherapy for HPV associated cancer
Frazer, Ian H. and Chandra, Janin (2019). Immunotherapy for HPV associated cancer. Papillomavirus Research, 8 100176, 100176. doi: 10.1016/j.pvr.2019.100176
Bashaw, Abate Assefa, Teoh, Siok M., Tuong, Zewen K., Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2019). HPV16 E7-driven epithelial hyperplasia promotes impaired antigen presentation and regulatory T cell development. Journal of Investigative Dermatology, 139 (12), 2467-2476.e3. doi: 10.1016/j.jid.2019.03.1162
Chakraborty, Rituparna, Chandra, Janin, Cui, Shuai, Tolley, Lynn, Cooper, Matthew A., Kendall, Mark and Frazer, Ian H. (2017). CD8+ lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury. Experimental Dermatology, 27 (1), 71-79. doi: 10.1111/exd.13436
Modulation of antigen presenting cell functions during chronic HPV infection
Bashaw, Abate Assefa, Leggatt, Graham R., Chandra, Janin, Tuong, Zewen K. and Frazer, Ian H. (2017). Modulation of antigen presenting cell functions during chronic HPV infection. Papillomavirus Research, 4, 58-65. doi: 10.1016/j.pvr.2017.08.002
Chandra, Janin, Dutton, Julie L., Li, Bo, Woo, Wai-Ping, Xu, Yan, Tolley, Lynn K., Yong, Michelle, Wells, James W., Leggatt, Graham R., Finlayson, Neil and Frazer, Ian H. (2017). DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection. Journal of Immunotherapy, 40 (2), 62-70. doi: 10.1097/CJI.0000000000000156
Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function
Chandra, Janin, Kuo, Paula T. Y., Hahn, Anne M., Belz, Gabrielle T. and Frazer, Ian H. (2016). Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function. Immunology and Cell Biology, 95 (2), 215-223. doi: 10.1038/icb.2016.83
Dutton, Julie L., Woo, Wai-Ping, Chandra, Janin, Xu, Yan, Li, Bo, Finlayson, Neil, Griffin, Paul and Frazer, Ian H. (2016). An escalating dose study to assess the safety, tolerability and immunogenicity of a Herpes Simplex Virus DNA vaccine, COR-1. Human Vaccines and Immunotherapeutics, 12 (12), 3079-3088. doi: 10.1080/21645515.2016.1221872
Chandra, Janin, Miao, Yan, Romoff, Natasha and Frazer, Ian H. (2016). Epithelium expressing the E7 oncoprotein of HPV16 attracts immune-modulatory dendritic cells to the skin and suppresses their antigen-processing capacity. Plos One, 11 (3) e0152886, e0152886. doi: 10.1371/journal.pone.0152886
Mittal, Deepak, Kassianos, Andrew. J, Tran, Lee S., Bergot, Anne-Sophie, Gosmann, Christina, Hofmann, Janin, Blumenthal, Antje, Leggatt, Graham R. and Frazer, Ian H. (2013). Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7. Journal of Investigative Dermatology, 133 (12), 2686-2694. doi: 10.1038/jid.2013.222
Winnik, Stephan, Lohmann, Christine, Richter, Eva K., Schäfer, Nicola, Song, Wen-Liang, Leiber, Florian, Mocharla, Pavani, Hofmann, Janin, Klingenberg, Roland, Borén, Jan, Becher, Burkhard, FitzGerald, Garret A., Lüscher, Thomas F., Matter, Christian M. and Beer, Jürg H. (2011). Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation. European Heart Journal, 32 (20), 2573-2584. doi: 10.1093/eurheartj/ehq501
Hofmann, Janin, Mair, Florian, Greter, Melanie, Schmidt-Supprian, Marc and Becher, Burkhard (2011). NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses. Journal of Experimental Medicine, 208 (9), 1917-1929. doi: 10.1084/jem.20110128
Frenz, Theresa, Waibler, Zoe, Hofmann, Janin, Hamdorf, Matthias, Lantermann, Markus, Reizis, Boris, Tovey, Michael G., Aichele, Peter, Sutter, Gerd and Kalinke, Ulrich (2010). Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion. European Journal of Immunology, 40 (10), 2769-2777. doi: 10.1002/eji.201040453
SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis
Stein, Sokrates, Lohmann, Christine, Schaefer, Nicola, Hofmann, Janin, Rohrer, Lucia, Besler, Christian, Rothgiesser, Karin M., Becher, Burkhard, Hottiger, Michael O., Boren, Jan, McBurney, Michael W., Landmesser, Ulf, Luescher, Thomas F. and Matter, Christian M. (2010). SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis. European Heart Journal, 31 (18), 2301-2309. doi: 10.1093/eurheartj/ehq107
Rozenberg, Izabela, Sluka, Susanna H. M., Rohrer, Lucia, Hofmann, Janin, Becher, Burkhard, Akhmedov, Alexander, Soliz, Jorge, Mocharla, Pavani, Boren, Jan, Johansen, Pal, Steffel, Jan, Watanabe, Takeshi, Luescher, Thomas F. and Tanner, Felix C. (2010). Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins. Arteriosclerosis Thrombosis and Vascular Biology, 30 (5), 923-U92. doi: 10.1161/ATVBAHA.109.201079
Hofmann, Janin, Greter, Melanie, Du Pasquier, Louis and Becher, Burkhard (2010). B-cells need a proper house, whereas T-cells are happy in a cave: the dependence of lymphocytes on secondary lymphoid tissues during evolution. Trends in Immunology, 31 (4), 144-153. doi: 10.1016/j.it.2010.01.003
Neo-lymphoid aggregates in the adult liver can initiate potent cell-mediated immunity
Greter, Melanie, Hofmann, Janin and Becher, Burkhard (2009). Neo-lymphoid aggregates in the adult liver can initiate potent cell-mediated immunity. PLoS Biology, 7 (5), e1000109. doi: 10.1371/journal.pbio.1000109
Immunotherapy for persisting viral infection and associated cancer
Frazer, I, Mattarollo, S., Leggatt, G., Wells, J., Tuong, K., Kuo, P., Jazayeri, S., Lambert, P. and Chandra, J. (2016). Immunotherapy for persisting viral infection and associated cancer. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.
Assessment of predictors of response to checkpoint blockade
(2021) PA Research Foundation
The role of different dendritic cell subsets in the clearance of papillomavirus infection
(2012–2016) UQ Postdoctoral Research Fellowship
Understanding CD4+ T cell responses to HPV16 E7 antigen in a mouse model of precancerous skin
Doctor Philosophy — Principal Advisor
Other advisors:
The role of bacterially induced inflammation in squamous skin cancer development
Doctor Philosophy — Associate Advisor
Modulation of Immune Responses by HPV-Induced Epithelial Hyperplasia
(2020) Doctor Philosophy — Associate Advisor
Other advisors: