The University of Queensland

Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: a randomized double blinded phase I/IIa trial

Chandra, Janin, Woo, Wai-Ping, Dutton, Julie L., Xu, Yan, Li, Bo, Kinrade, Sally, Druce, Julian, Finlayson, Neil, Griffin, Paul, Laing, Kerry J., Koelle, David M. and Frazer, Ian H. (2019) Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: a randomized double blinded phase I/IIa trial. PLoS One, 14 12: 1-20. doi:10.1371/journal.pone.0226320

Immunotherapy for HPV associated cancer

Frazer, Ian H. and Chandra, Janin (2019) Immunotherapy for HPV associated cancer. Papillomavirus Research, 8 100176. doi:10.1016/j.pvr.2019.100176

HPV16 E7-driven epithelial hyperplasia promotes impaired antigen presentation and regulatory T cell development

Bashaw, Abate Assefa, Teoh, Siok M., Tuong, Zewen K., Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2019) HPV16 E7-driven epithelial hyperplasia promotes impaired antigen presentation and regulatory T cell development. Journal of Investigative Dermatology, 139 12: 2467-2476.e3. doi:10.1016/j.jid.2019.03.1162

CD8+ lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury

Chakraborty, Rituparna, Chandra, Janin, Cui, Shuai, Tolley, Lynn, Cooper, Matthew A., Kendall, Mark and Frazer, Ian H. (2017) CD8+ lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury. Experimental Dermatology, 27 1: 71-79. doi:10.1111/exd.13436

Modulation of antigen presenting cell functions during chronic HPV infection

Bashaw, Abate Assefa, Leggatt, Graham R., Chandra, Janin, Tuong, Zewen K. and Frazer, Ian H. (2017) Modulation of antigen presenting cell functions during chronic HPV infection. Papillomavirus Research, 4 58-65. doi:10.1016/j.pvr.2017.08.002

DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection

Chandra, Janin, Dutton, Julie L., Li, Bo, Woo, Wai-Ping, Xu, Yan, Tolley, Lynn K., Yong, Michelle, Wells, James W., Leggatt, Graham R., Finlayson, Neil and Frazer, Ian H. (2017) DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection. Journal of Immunotherapy, 40 2: 62-70. doi:10.1097/CJI.0000000000000156

Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function

Chandra, Janin, Kuo, Paula T. Y., Hahn, Anne M., Belz, Gabrielle T. and Frazer, Ian H. (2016) Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function. Immunology and Cell Biology, 95 2: 215-223. doi:10.1038/icb.2016.83

An escalating dose study to assess the safety, tolerability and immunogenicity of a Herpes Simplex Virus DNA vaccine, COR-1

Dutton, Julie L., Woo, Wai-Ping, Chandra, Janin, Xu, Yan, Li, Bo, Finlayson, Neil, Griffin, Paul and Frazer, Ian H. (2016) An escalating dose study to assess the safety, tolerability and immunogenicity of a Herpes Simplex Virus DNA vaccine, COR-1. Human Vaccines and Immunotherapeutics, 12 12: 3079-3088. doi:10.1080/21645515.2016.1221872

Epithelium expressing the E7 oncoprotein of HPV16 attracts immune-modulatory dendritic cells to the skin and suppresses their antigen-processing capacity

Chandra, Janin, Miao, Yan, Romoff, Natasha and Frazer, Ian H. (2016) Epithelium expressing the E7 oncoprotein of HPV16 attracts immune-modulatory dendritic cells to the skin and suppresses their antigen-processing capacity. Plos One, 11 3: e0152886. doi:10.1371/journal.pone.0152886

Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7

Mittal, Deepak, Kassianos, Andrew. J, Tran, Lee S., Bergot, Anne-Sophie, Gosmann, Christina, Hofmann, Janin, Blumenthal, Antje, Leggatt, Graham R. and Frazer, Ian H. (2013) Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7. Journal of Investigative Dermatology, 133 12: 2686-2694. doi:10.1038/jid.2013.222

Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation

Winnik, Stephan, Lohmann, Christine, Richter, Eva K., Schäfer, Nicola, Song, Wen-Liang, Leiber, Florian, Mocharla, Pavani, Hofmann, Janin, Klingenberg, Roland, Borén, Jan, Becher, Burkhard, FitzGerald, Garret A., Lüscher, Thomas F., Matter, Christian M. and Beer, Jürg H. (2011) Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation. European Heart Journal, 32 20: 2573-2584. doi:10.1093/eurheartj/ehq501

NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses

Hofmann, Janin, Mair, Florian, Greter, Melanie, Schmidt-Supprian, Marc and Becher, Burkhard (2011) NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses. Journal of Experimental Medicine, 208 9: 1917-1929. doi:10.1084/jem.20110128

Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion

Frenz, Theresa, Waibler, Zoe, Hofmann, Janin, Hamdorf, Matthias, Lantermann, Markus, Reizis, Boris, Tovey, Michael G., Aichele, Peter, Sutter, Gerd and Kalinke, Ulrich (2010) Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion. European Journal of Immunology, 40 10: 2769-2777. doi:10.1002/eji.201040453

SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis

Stein, Sokrates, Lohmann, Christine, Schaefer, Nicola, Hofmann, Janin, Rohrer, Lucia, Besler, Christian, Rothgiesser, Karin M., Becher, Burkhard, Hottiger, Michael O., Boren, Jan, McBurney, Michael W., Landmesser, Ulf, Luescher, Thomas F. and Matter, Christian M. (2010) SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis. European Heart Journal, 31 18: 2301-2309. doi:10.1093/eurheartj/ehq107

Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins

Rozenberg, Izabela, Sluka, Susanna H. M., Rohrer, Lucia, Hofmann, Janin, Becher, Burkhard, Akhmedov, Alexander, Soliz, Jorge, Mocharla, Pavani, Boren, Jan, Johansen, Pal, Steffel, Jan, Watanabe, Takeshi, Luescher, Thomas F. and Tanner, Felix C. (2010) Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins. Arteriosclerosis Thrombosis and Vascular Biology, 30 5: 923-U92. doi:10.1161/ATVBAHA.109.201079

B-cells need a proper house, whereas T-cells are happy in a cave: the dependence of lymphocytes on secondary lymphoid tissues during evolution

Hofmann, Janin, Greter, Melanie, Du Pasquier, Louis and Becher, Burkhard (2010) B-cells need a proper house, whereas T-cells are happy in a cave: the dependence of lymphocytes on secondary lymphoid tissues during evolution. Trends in Immunology, 31 4: 144-153. doi:10.1016/j.it.2010.01.003

Neo-lymphoid aggregates in the adult liver can initiate potent cell-mediated immunity

Greter, Melanie, Hofmann, Janin and Becher, Burkhard (2009) Neo-lymphoid aggregates in the adult liver can initiate potent cell-mediated immunity. PLoS Biology, 7 5: . doi:10.1371/journal.pbio.1000109

Immunotherapy for persisting viral infection and associated cancer

Frazer, I, Mattarollo, S., Leggatt, G., Wells, J., Tuong, K., Kuo, P., Jazayeri, S., Lambert, P. and Chandra, J. (2016). Immunotherapy for persisting viral infection and associated cancer. In: ICI 2016 International Congress of Immunology, Melbourne, Australia, (2). 21-26 August 2016.