The University of Queensland

The m6A-epitranscriptome in brain plasticity, learning and memory

Widagdo, Jocelyn, Wong, Justin J.-L. and Anggono, Victor (2022). The m6A-epitranscriptome in brain plasticity, learning and memory. Seminars in Cell and Developmental Biology, 125, 110-121. doi: 10.1016/j.semcdb.2021.05.023

Altered expression of the m6A methyltransferase METTL3 in Alzheimer’s disease

Huang (黄 河), He, Camats-Perna, Judith, Medeiros, Rodrigo, Anggono, Victor and Widagdo, Jocelyn (2020). Altered expression of the m6A methyltransferase METTL3 in Alzheimer’s disease. eNeuro, 7 (5) ENEURO.0125-20.2020, ENEURO.0125-20.2020. doi: 10.1523/eneuro.0125-20.2020

The m6A-epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity

Widagdo, Jocelyn and Anggono, Victor (2018). The m6A-epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity. Journal of Neurochemistry, 147 (2), 137-152. doi: 10.1111/jnc.14481

Ubiquitination regulates the proteasomal degradation and nuclear translocation of the fat mass and obesity-associated (FTO) protein

Zhu, Tianyi, Yong, Xuan Ling Hilary, Di, Xia, Widagdo, Jocelyn and Anggono, Victor (2018). Ubiquitination regulates the proteasomal degradation and nuclear translocation of the fat mass and obesity-associated (FTO) protein. Journal of Molecular Biology, 430 (3), 363-371. doi: 10.1016/j.jmb.2017.12.003

Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice

Widagdo, Jocelyn, Zhao, Qiong-Yi, Kempen, Marie-Jeanne, Tan, Men Chee, Ratnu, Vikram S., Wei, Wei, Leighton, Laura, Spadaro, Paola A., Edson, Janette, Anggono, Victor and Bredy, Timothy W. (2016). Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice. Journal of Neuroscience, 36 (25), 6771-6777. doi: 10.1523/JNEUROSCI.4053-15.2016

Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation

Widagdo, Jocelyn, Chai, Ye Jin, Ridder, Margreet C, Chau, Yu Qian, Johnson, Richard C, Sah, Pankaj, Huganir, Richard L and Anggono, Victor (2015). Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation. Cell Reports, 10 (5), 783-795. doi: 10.1016/j.celrep.2015.01.015

Global quantitative proteomic analysis of aged mouse hippocampus

Huang, He, van Waardenberg, Ashley J., Graham, Mark E., Anggono, Victor and Widagdo, Jocelyn (2023). Global quantitative proteomic analysis of aged mouse hippocampus. PROTEOMICS, e2300276. doi: 10.1002/pmic.202300276

Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis

Tan, Jing Zhi Anson, Jang, Se Eun, Batallas-Borja, Ana, Bhembre, Nishita, Chandra, Mintu, Zhang, Lingrui, Guo, Huimin, Ringuet, Mitchell T., Widagdo, Jocelyn, Collins, Brett M. and Anggono, Victor (2023). Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis. Cell Reports, 42 (12) 113460, 1-20. doi: 10.1016/j.celrep.2023.113460

Different low-complexity regions of SFPQ play distinct roles in the formation of biomolecular condensates

Marshall, Andrew C., Cummins, Jerry, Kobelke, Simon, Zhu, Tianyi, Widagdo, Jocelyn, Anggono, Victor, Hyman, Anthony, Fox, Archa H., Bond, Charles S. and Lee, Mihwa (2023). Different low-complexity regions of SFPQ play distinct roles in the formation of biomolecular condensates. Journal of Molecular Biology, 435 (24) 168364, 168364. doi: 10.1016/j.jmb.2023.168364

Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice

Leiter, Odette, Brici, David, Fletcher, Stephen J., Yong, Xuan Ling Hilary, Widagdo, Jocelyn, Matigian, Nicholas, Schroer, Adam B., Bieri, Gregor, Blackmore, Daniel G., Bartlett, Perry F., Anggono, Victor, Villeda, Saul A. and Walker, Tara L. (2023). Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice. Nature Communications, 14 (1) 4375, 1-20. doi: 10.1038/s41467-023-39873-9

Ubiquitination of the GluA1 subunit of AMPA receptors is required for synaptic plasticity, memory and cognitive flexibility

Guntupalli, Sumasri, Park, Pojeong, Han, Dae Hee, Zhang, Lingrui, Yong, Xuan Ling Hilary, Ringuet, Mitchell, Blackmore, Daniel G., Jhaveri, Dhanisha J., Koentgen, Frank, Widagdo, Jocelyn, Kaang, Bong-Kiun and Anggono, Victor (2023). Ubiquitination of the GluA1 subunit of AMPA receptors is required for synaptic plasticity, memory and cognitive flexibility. The Journal of Neuroscience, 43 (30), 5448-5457. doi: 10.1523/jneurosci.1542-22.2023

Identification of phosphorylated Tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission

Radford, Rowan A. W., Rayner, Stephanie L., Szwaja, Paulina, Morsch, Marco, Cheng, Flora, Zhu, Tianyi, Widagdo, Jocelyn, Anggono, Victor, Pountney, Dean L., Chung, Roger and Lee, Albert (2023). Identification of phosphorylated Tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission. Journal of Neurochemistry, 165 (4), 563-586. doi: 10.1111/jnc.15796

The N 6 ‐methyladenosine RNA landscape in the aged mouse hippocampus

Huang, He, Song, Renhua, Wong, Justin J.‐L., Anggono, Victor and Widagdo, Jocelyn (2023). The N 6 ‐methyladenosine RNA landscape in the aged mouse hippocampus. Aging Cell, 22 (1) e13755, 1-8. doi: 10.1111/acel.13755

Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons

Widagdo, Jocelyn, Udagedara, Saumya, Bhembre, Nishita, Tan, Jing Zhi Anson, Neureiter, Lara, Huang, Jie, Anggono, Victor and Lee, Mihwa (2022). Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons. Open Biology, 12 (9) 220187, 1-12. doi: 10.1098/rsob.220187

The m6A-epitranscriptome in brain plasticity, learning and memory

Widagdo, Jocelyn, Wong, Justin J.-L. and Anggono, Victor (2022). The m6A-epitranscriptome in brain plasticity, learning and memory. Seminars in Cell and Developmental Biology, 125, 110-121. doi: 10.1016/j.semcdb.2021.05.023

The multifaceted effects of YTHDC1-mediated nuclear m6A recognition

Widagdo, Jocelyn, Anggono, Victor and Wong, Justin J.-L. (2022). The multifaceted effects of YTHDC1-mediated nuclear m6A recognition. Trends in Genetics, 38 (4), 325-332. doi: 10.1016/j.tig.2021.11.005

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit

Yong, Xuan Ling Hilary, Zhang, Lingrui, Yang, Liming, Chen, Xiumin, Tan, Jing Zhi Anson, Yu, Xiaojun, Chandra, Mintu, Livingstone, Emma, Widagdo, Jocelyn, Vieira, Marta M., Roche, Katherine W., Lynch, Joseph W., Keramidas, Angelo, Collins, Brett M. and Anggono, Victor (2021). Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit. Cell Reports, 36 (1) 109338, 1-21. doi: 10.1016/j.celrep.2021.109338

Altered expression of the m6A methyltransferase METTL3 in Alzheimer’s disease

Huang (黄 河), He, Camats-Perna, Judith, Medeiros, Rodrigo, Anggono, Victor and Widagdo, Jocelyn (2020). Altered expression of the m6A methyltransferase METTL3 in Alzheimer’s disease. eNeuro, 7 (5) ENEURO.0125-20.2020, ENEURO.0125-20.2020. doi: 10.1523/eneuro.0125-20.2020

Subunit-specific augmentation of AMPA receptor ubiquitination by phorbol ester

Widagdo, Jocelyn, Kerk, Jun Wei, Guntupalli, Sumasri, Huganir, Richard L. and Anggono, Victor (2020). Subunit-specific augmentation of AMPA receptor ubiquitination by phorbol ester. Cellular and Molecular Neurobiology, 40 (7), 1213-1222. doi: 10.1007/s10571-020-00809-2

The interaction between contactin and amyloid precursor protein and its role in Alzheimer’s disease

Bamford, Rosemary A., Widagdo, Jocelyn, Takamura, Natsuki, Eve, Madeline, Anggono, Victor and Oguro-Ando, Asami (2020). The interaction between contactin and amyloid precursor protein and its role in Alzheimer’s disease. Neuroscience, 424, 184-202. doi: 10.1016/j.neuroscience.2019.10.006

NFIX-mediated inhibition of neuroblast branching regulates migration within the adult mouse ventricular–subventricular zone

Zalucki, Oressia, Harris, Lachlan, Harvey, Tracey J., Harkins, Danyon, Widagdo, Jocelyn, Oishi, Sabrina, Matuzelski, Elise, Yong, Xuan Ling Hilary, Schmidt, Hannes, Anggono, Victor, Burne, Thomas H. J., Gronostajski, Richard M. and Piper, Michael (2019). NFIX-mediated inhibition of neuroblast branching regulates migration within the adult mouse ventricular–subventricular zone. Cerebral Cortex, 29 (8), 3590-3604. doi: 10.1093/cercor/bhy233

The m6A-epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity

Widagdo, Jocelyn and Anggono, Victor (2018). The m6A-epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity. Journal of Neurochemistry, 147 (2), 137-152. doi: 10.1111/jnc.14481

Ubiquitination regulates the proteasomal degradation and nuclear translocation of the fat mass and obesity-associated (FTO) protein

Zhu, Tianyi, Yong, Xuan Ling Hilary, Di, Xia, Widagdo, Jocelyn and Anggono, Victor (2018). Ubiquitination regulates the proteasomal degradation and nuclear translocation of the fat mass and obesity-associated (FTO) protein. Journal of Molecular Biology, 430 (3), 363-371. doi: 10.1016/j.jmb.2017.12.003

Regulation of AMPA receptor trafficking by protein ubiquitination

Widagdo, Jocelyn, Guntupalli, Sumasri, Jang, Se E. and Anggono, Victor (2017). Regulation of AMPA receptor trafficking by protein ubiquitination. Frontiers in Molecular Neuroscience, 10 347, 347. doi: 10.3389/fnmol.2017.00347

MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life

Lin, Quan, Ponnusamy, Ravikumar, Widagdo, Jocelyn, Choi, Jung A., Ge, Weihong, Probst, Christine, Buckley, Tyler, Lou, Mimi, Bredy, Timothy W., Fanselow, Michael S., Ye, Keqiang and Sun, Yi E. (2017). MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life. Proceedings from the National Academy of Sciences of the United States of America, 114 (34), 9188-9193. doi: 10.1073/pnas.1706069114

GluA1 subunit ubiquitination mediates amyloid-beta-induced loss of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors

Guntupalli, Sumasri, Jang, Se Eun, Zhu, Tianyi, Huganir, Richard L., Widagdo, Jocelyn and Anggono, Victor (2017). GluA1 subunit ubiquitination mediates amyloid-beta-induced loss of surface alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Journal of Biological Chemistry, 292 (20), 8186-8194. doi: 10.1074/jbc.M116.774554

The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons

Tan, Men C., Widagdo, Jocelyn, Chau, Yu Q., Zhu, Tianyi, Wong, Justin J.-L, Cheung, Allen and Anggono, Victor (2017). The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons. Frontiers in Cellular Neuroscience, 11 124, 124.1-124.12. doi: 10.3389/fncel.2017.00124

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex

Clairfeuille, Thomas, Mas, Caroline, Chan, Audrey S. M., Yang, Zhe, Tello-Lafoz, Maria, Chandra, Mintu, Wigagdo, Jocelyn, Kerr, Markus, Blessy, Paul, Merida, Isabel, Teasdale, Rohan D., Pavlos, Nathan J., Anggono, Victor and Collins, Brett (2016). A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex. Nature Structural and Molecular Biology, 23 (10), 921-932. doi: 10.1038/nsmb.3290

PACSIN1 regulates the dynamics of AMPA receptor trafficking

Widagdo, Jocelyn, Fang, Huaqiang, Jang, Se Eun and Anggono, Victor (2016). PACSIN1 regulates the dynamics of AMPA receptor trafficking. Scientific Reports, 6 (31070) 31070, 1-9. doi: 10.1038/srep31070

Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice

Widagdo, Jocelyn, Zhao, Qiong-Yi, Kempen, Marie-Jeanne, Tan, Men Chee, Ratnu, Vikram S., Wei, Wei, Leighton, Laura, Spadaro, Paola A., Edson, Janette, Anggono, Victor and Bredy, Timothy W. (2016). Experience-dependent accumulation of N6-methyladenosine in the prefrontal cortex is associated with memory processes in mice. Journal of Neuroscience, 36 (25), 6771-6777. doi: 10.1523/JNEUROSCI.4053-15.2016

Amyloid-β-induced dysregulation of AMPA receptor trafficking

Guntupalli, Sumasri, Widagdo, Jocelyn and Anggono, Victor (2016). Amyloid-β-induced dysregulation of AMPA receptor trafficking. Neural Plasticity, 2016 3204519, 1-12. doi: 10.1155/2016/3204519

The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation

Carmona-Mora, Paulina, Widagdo, Jocelyn, Tomasetig, Florence, Canales, Cesar P, Cha, Yeojoon, Lee, Wei, Alshawaf, Abdullah, Dottori, Mirella, Whan, Renee M, Hardeman, Edna C and Palmer, Stephen J (2015). The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation. Human Genetics, 134 (10), 1099-1115. doi: 10.1007/s00439-015-1591-0

Ubiquitin signals the demise of AMPA receptors

Widagdo, Jocelyn and Anggono, Victor (2015). Ubiquitin signals the demise of AMPA receptors. Oncotarget, 6 (18), 15718-15719. doi: 10.18632/oncotarget.4645

Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation

Widagdo, Jocelyn, Chai, Ye Jin, Ridder, Margreet C, Chau, Yu Qian, Johnson, Richard C, Sah, Pankaj, Huganir, Richard L and Anggono, Victor (2015). Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation. Cell Reports, 10 (5), 783-795. doi: 10.1016/j.celrep.2015.01.015

Long noncoding RNA-directed epigenetic regulation of gene expression is associated with anxiety-like behavior in mice

Spadaro, Paola A., Flavell, Charlotte R., Widagdo, Jocelyn, Ratnu, Vikram S., Troup, Michael, Ragan, Chikako, Mattick, John S. and Bredy, Timothy W. (2015). Long noncoding RNA-directed epigenetic regulation of gene expression is associated with anxiety-like behavior in mice. Biological Psychiatry, 78 (12), 848-859. doi: 10.1016/j.biopsych.2015.02.004

Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation

Li, Xiang, Wei, Wei, Zhao, Qiong-Yi, Widagdo, Jocelyn, Baker-Andresen, Danay, Flavell, Charlotte R., D'Alessio, Ana, Zhang, Yi and Bredy, Timothy W. (2014). Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation. Proceedings of the National Academy of Sciences, 111 (19), 7120-7125. doi: 10.1073/pnas.1318906111

PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression

Anggono, Victor, Koc-Schmitz, Yeliz, Widagdo, Jocelyn, Kormann, Jan, Quan, Annie, Chen, Chih-Ming, Robinson, Phillip J., Choi, Se-Young, Linden, David J., Plomann, Markus and Huganir, Richard L. (2013). PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. Proceedings of the National Academy of Sciences of the United States of America, 110 (34), 13976-13981. doi: 10.1073/pnas.1312467110

SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation

Widagdo, Jocelyn, Taylor, Kylie M., Gunning, Peter W., Hardeman, Edna C. and Palmer, Stephen J. (2012). SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation. PLoS One, 7 (11) e49283, e49283. doi: 10.1371/journal.pone.0049283

GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members

Palmer, Stephen J., Taylor, Kylie M., Santucci, Nicole, Widagdo, Jocelyn, Chan, Yee-Ka Agnes, Yeo, Jen-Li, Adams, Merritt, Gunning, Peter W. and Hardeman, Edna C. (2012). GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members. Journal of Cell Science, 125 (21), 5040-5050. doi: 10.1242/jcs.102798

Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism

Palmer, Stephen J., Santucci, Nicole, Widagdo, Jocelyn, Bontempo, Sara J., Taylor, Kylie M., Tay, Enoch S. E., Hook, Jeff, Lemckert, Frances, Gunning, Peter W. and Hardeman, Edna C. (2010). Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism. Journal of Biological Chemistry, 285 (7), 4715-4724. doi: 10.1074/jbc.M109.086660

Activity-dependent RNA methylation in learning and memory

Widagdo, J. (2017). Activity-dependent RNA methylation in learning and memory. ISN-ESN 2017 Meeting, Paris, France, 20-24 August 2017. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/jnc.14090

Activity-dependent RNA methylation in learning and memory

Widagdo, J., Zhao, Q. -Y., Anggono, V. and Bredy, T. (2015). Activity-dependent RNA methylation in learning and memory. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

Epitranscriptomic mechanisms of memory stability

Bredy, T., Widagdo, J. and Zhao, Q.-Y. (2015). Epitranscriptomic mechanisms of memory stability. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13185