The University of Queensland

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Gordon, Richard, Albornoz, Eduardo A., Christie, Daniel C., Langley, Monica R., Kumar, Vinod, Mantovani, Susanna, Robertson, Avril A. B., Butler, Mark S., Rowe, Dominic B., O'Neill, Luke A., Kanthasamy, Anumantha G., Schroder, Kate, Cooper, Matthew A. and Woodruff, Trent M. (2018). Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine, 10 (465) aah4066, eaah4066. doi: 10.1126/scitranslmed.aah4066

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation

Chen, Weiqiang, Foo, Suan-Sin, Zaid, Ali, Teng, Terk-Shin, Herrero, Lara J., Wolf, Stefan, Tharmarajah, Kothila, Vu, Luan D., van Vreden, Caryn, Taylor, Adam, Freitas, Joseph R., Li, Rachel W., Woodruff, Trent M., Gordon, Richard, Ojcius, David M., Nakaya, Helder I., Kanneganti, Thirumala-Devi, O’Neill, Luke A. J., Robertson, Avril A. B., King, Nicholas J., Suhrbier, Andreas, Cooper, Matthew A., Ng, Lisa F. P. and Mahalingam, Suresh (2017). Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology, 2 (10), 1-11. doi: 10.1038/s41564-017-0015-4

Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration

Gordon, Richard, Neal, Matthew L., Luo, Jie, Langley, Monica R., Harischandra, Dilshan S., Panicker, Nikhil, Charli, Adhithiya, Jin, Huajun, Anantharam, Vellareddy, Woodruff, Trent M., Zhou, Qun-Yong, Kanthasamy, Anumantha G. and Kanthasamy, Arthi (2016). Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nature Communications, 7 (1) 12932, 12932.1-12932.18. doi: 10.1038/ncomms12932

Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

Gordon, Richard, Singh, Neeraj, Lawana, Vivek, Ghosh, Anamitra, Harischandra, Dilshan S., Jin, Huajun, Hogan, Colleen, Sarkar, Souvarish, Rokad, Dharmin, Panicker, Nikhil, Anantharam, Vellareddy, Kanthasamy, Anumantha G. and Kanthasamy, Arthi (2016). Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease. Neurobiology of Disease, 93, 96-114. doi: 10.1016/j.nbd.2016.04.008

Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice

Mantovani, Susanna, Gordon, Richard, Li, Rui, Christie, Daniel C., Kumar, Vinod and Woodruff, Trent M. (2016). Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice. Human Molecular Genetics, 25 (9) ddw050, 1780-1791. doi: 10.1093/hmg/ddw050

The complement receptor C5aR controls acute inflammation and astrogliosis following spinal cord injury

Brennan, Faith H., Gordon, Richard, Lao, Hong W., Biggins, Patrick J., Taylor, Stephen M., Franklin, Robin J. M., Woodruff, Trent M. and Ruitenberg, Marc J. (2015). The complement receptor C5aR controls acute inflammation and astrogliosis following spinal cord injury. Journal of Neuroscience, 35 (16), 6517-6531. doi: 10.1523/JNEUROSCI.5218-14.2015

Inflammasomes in CNS diseases

Albornoz, Eduardo A., Woodruff, Trent M. and Gordon, Richard (2018). Inflammasomes in CNS diseases. Inflammasomes: clinical and therapeutic implications. (pp. 41-60) edited by Mario D. Cordero and Elisabet Alcocer-Gómez. Cham, Switzerland: Springer International. doi: 10.1007/978-3-319-89390-7_3

Neuroinflammation as a therapeutic target in neurodegenerative diseases

Gordon, Richard and Woodruff, Trent M. (2017). Neuroinflammation as a therapeutic target in neurodegenerative diseases. Disease-modifying targets in neurodegenerative disorders: paving the way for disease-modifying therapies. (pp. 49-80) edited by Veerle Baekelandt and Evy Lobbestael. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-805120-7.00003-8

Neuroinflammation as a therapeutic target in neurodegenerative diseases

Gordon, Richard and Woodruff, Trent M. (2017). Neuroinflammation as a therapeutic target in neurodegenerative diseases. Disease-modifying targets in neurodegenerative disorders. (pp. 43-64) edited by Veerle Baekelandt and Evy Lobbestael. Boston, MA, United States: Academic Press (Elsevier Press).

Pharmacological Inhibition of PTEN Rescues Dopaminergic Neurons by Attenuating Apoptotic and Neuroinflammatory Signaling Events

Johnson, Aishwarya Mary, Jose, Sara, Palakkott, Abdul Rasheed, Khan, Farheen Badrealam, Jayabalan, Nanthini, Kizhakkayil, Jaleel, AlNaqbi, Shamma Abdulla Ali, Scott, Mark GH, Ayoub, Mohammed Akli, Gordon, Richard and Saminathan, Hariharan (2023). Pharmacological Inhibition of PTEN Rescues Dopaminergic Neurons by Attenuating Apoptotic and Neuroinflammatory Signaling Events. Journal of Neuroimmune Pharmacology, 1-14. doi: 10.1007/s11481-023-10077-8

Response to Comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”

Albornoz, Eduardo A., Gordon, Richard, Kumar, Vinod, Robertson, Avril A. B., Schroder, Kate and Woodruff, Trent M. (2023). Response to Comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”. Science Translational Medicine, 15 (696) adh0604. doi: 10.1126/scitranslmed.adh0604

A review of RRx-001: a late-stage multi-indication inhibitor of NLRP3 activation and chronic inflammation

Jayabalan, Nanthini, Oronsky, Bryan, Cabrales, Pedro, Reid, Tony, Caroen, Scott, Johnson, Aishwarya M., Birch, Natalia A., O’Sullivan, John D. and Gordon, Richard (2023). A review of RRx-001: a late-stage multi-indication inhibitor of NLRP3 activation and chronic inflammation. Drugs, 83 (5), 389-402. doi: 10.1007/s40265-023-01838-z

RRx-001: a chimeric triple action NLRP3 inhibitor, Nrf2 inducer, and nitric oxide superagonist

Oronsky, Bryan, Takahashi, Lori, Gordon, Richard, Cabrales, Pedro, Caroen, Scott and Reid, Tony (2023). RRx-001: a chimeric triple action NLRP3 inhibitor, Nrf2 inducer, and nitric oxide superagonist. Frontiers in Oncology, 13 1204143. doi: 10.3389/fonc.2023.1204143

Inflammasome activation in Parkinson's disease

Jewell, Shannon, Herath, Ashane M. and Gordon, Richard (2022). Inflammasome activation in Parkinson's disease. Journal of Parkinson's Disease, 12 (s1), S113-S128. doi: 10.3233/JPD-223338

Mechanisms of NLRP3 activation and pathology during neurodegeneration

Jose, Sara, Groves, Natalie J., Roper, Kathrein E. and Gordon, Richard (2022). Mechanisms of NLRP3 activation and pathology during neurodegeneration. The International Journal of Biochemistry & Cell Biology, 151 106273, 106273. doi: 10.1016/j.biocel.2022.106273

LC-MS based urine metabolomic profiling indicate altered gut microbiome and host lipid metabolites in Parkinson's disease

Jewell, Shannon, Roper, Kerry, Woodhouse, Helen, Adam, Robert, O'Sullivan, John and Gordon, Richard (2022). LC-MS based urine metabolomic profiling indicate altered gut microbiome and host lipid metabolites in Parkinson's disease. The FASEB Journal, 36 (S1). doi: 10.1096/fasebj.2022.36.S1.R2928

Environmental neurotoxicants and inflammasome activation in Parkinson’s disease – a focus on the gut-brain axis

Johnson, Aishwarya M., Ou, Zhen-Yi Andy, Gordon, Richard and Saminathan, Hariharan (2022). Environmental neurotoxicants and inflammasome activation in Parkinson’s disease – a focus on the gut-brain axis. The International Journal of Biochemistry and Cell Biology, 142 106113, 106113. doi: 10.1016/j.biocel.2021.106113

Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research

Saminathan, Hariharan, Charli, Adhithiya, Luo, Jie, Panicker, Nikhil, Gordon, Richard, Hostetter, Jesse M, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Anumantha G and Kanthasamy, Arthi (2020). Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research. European journal of pharmacology, 881 173259, 173259. doi: 10.1016/j.ejphar.2020.173259

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) enhances activation of STAT3/NLRC4 inflammasome signaling axis through PKCδ in astrocytes: implications for Parkinson's disease

Samidurai, Manikandan, Tarale, Prashant, Janarthanam, Chelva, Estrada, Crystal Gomez, Gordon, Richard, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Anumantha G. and Kanthasamy, Arthi (2020). Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) enhances activation of STAT3/NLRC4 inflammasome signaling axis through PKCδ in astrocytes: implications for Parkinson's disease. Cells, 9 (8) 1831, 1831-35. doi: 10.3390/cells9081831

Interaction of the brain-selective sulfotransferase SULT4A1 with other cytosolic sulfotransferases: effects on protein expression and function

Idris, Misgana, Mitchell, Deanne J., Gordon, Richard, Sidharthan, Neelima P., Butcher, Neville J. and Minchin, Rodney F. (2020). Interaction of the brain-selective sulfotransferase SULT4A1 with other cytosolic sulfotransferases: effects on protein expression and function. Drug Metabolism and Disposition, 48 (5), 337-344. doi: 10.1124/dmd.119.089714

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

Deora, Vandana, Lee, John D., Albornoz, Eduardo A., McAlary, Luke, Jagaraj, Cyril J., Robertson, Avril A. B., Atkin, Julie D, Cooper, Matthew A., Schroder, Kate, Yerbury, Justin J., Gordon, Richard and Woodruff, Trent M. (2020). The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins. Glia, 68 (2) glia.23728, 407-421. doi: 10.1002/glia.23728

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Gordon, Richard, Albornoz, Eduardo A., Christie, Daniel C., Langley, Monica R., Kumar, Vinod, Mantovani, Susanna, Robertson, Avril A. B., Butler, Mark S., Rowe, Dominic B., O'Neill, Luke A., Kanthasamy, Anumantha G., Schroder, Kate, Cooper, Matthew A. and Woodruff, Trent M. (2018). Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine, 10 (465) aah4066, eaah4066. doi: 10.1126/scitranslmed.aah4066

Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes

Neal, Matthew, Luo, Jie, Harischandra, Dilshan S., Gordon, Richard, Sarkar, Souvarish, Jin, Huajun, Anantharam, Vellareddy, Désaubry, Laurent, Kanthasamy, Anumantha and Kanthasamy, Arthi (2018). Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes. Glia, 66 (10), 2137-2157. doi: 10.1002/glia.23467

An overview of sleep and circadian dysfunction in Parkinson's disease

Mantovani, Susanna, Smith, Simon S., Gordon, Richard and O'Sullivan, John D. (2018). An overview of sleep and circadian dysfunction in Parkinson's disease. Journal of Sleep Research, 27 (3) e12673, e12673. doi: 10.1111/jsr.12673

Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviour

Giacomin, Paul R., Kraeuter, Ann Katrin, Albornoz, Eduardo A., Jin, Shuting, Bengtsson, Mia, Gordon, Richard, Woodruff, Trent M., Urich, Tim, Sarnyai, Zoltán and Soares Magalhães, Ricardo J. (2018). Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviour. The Journal of Infectious Diseases, 218 (9), 1511-1516. doi: 10.1093/infdis/jiy092

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation

Chen, Weiqiang, Foo, Suan-Sin, Zaid, Ali, Teng, Terk-Shin, Herrero, Lara J., Wolf, Stefan, Tharmarajah, Kothila, Vu, Luan D., van Vreden, Caryn, Taylor, Adam, Freitas, Joseph R., Li, Rachel W., Woodruff, Trent M., Gordon, Richard, Ojcius, David M., Nakaya, Helder I., Kanneganti, Thirumala-Devi, O’Neill, Luke A. J., Robertson, Avril A. B., King, Nicholas J., Suhrbier, Andreas, Cooper, Matthew A., Ng, Lisa F. P. and Mahalingam, Suresh (2017). Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology, 2 (10), 1-11. doi: 10.1038/s41564-017-0015-4

The ketone body β-hydroxybutyrate does not inhibit synuclein mediated inflammasome activation in microglia

Deora, Vandana, Albornoz, Eduardo A., Zhu, Kevin, Woodruff, Trent M. and Gordon, Richard (2017). The ketone body β-hydroxybutyrate does not inhibit synuclein mediated inflammasome activation in microglia. Journal of Neuroimmune Pharmacology, 12 (4), 1-7. doi: 10.1007/s11481-017-9754-5

Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration

Gordon, Richard, Neal, Matthew L., Luo, Jie, Langley, Monica R., Harischandra, Dilshan S., Panicker, Nikhil, Charli, Adhithiya, Jin, Huajun, Anantharam, Vellareddy, Woodruff, Trent M., Zhou, Qun-Yong, Kanthasamy, Anumantha G. and Kanthasamy, Arthi (2016). Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nature Communications, 7 (1) 12932, 12932.1-12932.18. doi: 10.1038/ncomms12932

Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

Gordon, Richard, Singh, Neeraj, Lawana, Vivek, Ghosh, Anamitra, Harischandra, Dilshan S., Jin, Huajun, Hogan, Colleen, Sarkar, Souvarish, Rokad, Dharmin, Panicker, Nikhil, Anantharam, Vellareddy, Kanthasamy, Anumantha G. and Kanthasamy, Arthi (2016). Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease. Neurobiology of Disease, 93, 96-114. doi: 10.1016/j.nbd.2016.04.008

p73 gene in dopaminergic neurons is highly susceptible to manganese neurotoxicity

Kim, Dong-Suk, Jin, Huajun, Anantharam, Vellareddy, Gordon, Richard, Kanthasamy, Arthi and Kanthasamy, Anumantha G. (2016). p73 gene in dopaminergic neurons is highly susceptible to manganese neurotoxicity. NeuroToxicology, 59, 231-239. doi: 10.1016/j.neuro.2016.04.012

Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice

Mantovani, Susanna, Gordon, Richard, Li, Rui, Christie, Daniel C., Kumar, Vinod and Woodruff, Trent M. (2016). Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice. Human Molecular Genetics, 25 (9) ddw050, 1780-1791. doi: 10.1093/hmg/ddw050

Fyn kinase regulates microglial neuroinflammatory responses in cell culture and animal models of parkinson’s disease

Panicker, Nikhil, Saminathan, Hariharan, Jin, Huajun, Neal, Matthew, Harischandra, Dilshan S., Gordon, Richard, Kanthasamy, Kavin, Lawana, Vivek, Sarkar, Souvarish, Luo, Jie, Anantharam, Vellareddy, Kanthasamy, Anumantha G. and Kanthasamy, Arthi (2015). Fyn kinase regulates microglial neuroinflammatory responses in cell culture and animal models of parkinson’s disease. Journal of Neuroscience, 35 (27), 10058-10077. doi: 10.1523/JNEUROSCI.0302-15.2015

Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cord

Khan, Nemat, Gordon, Richard, Woodruff, Trent M. and Smith, Maree T. (2015). Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cord. Pharmacology Research and Perspectives, 3 (3) e00137, 1-16. doi: 10.1002/prp2.137

The complement receptor C5aR controls acute inflammation and astrogliosis following spinal cord injury

Brennan, Faith H., Gordon, Richard, Lao, Hong W., Biggins, Patrick J., Taylor, Stephen M., Franklin, Robin J. M., Woodruff, Trent M. and Ruitenberg, Marc J. (2015). The complement receptor C5aR controls acute inflammation and astrogliosis following spinal cord injury. Journal of Neuroscience, 35 (16), 6517-6531. doi: 10.1523/JNEUROSCI.5218-14.2015

Elevation of the terminal complement activation products C5a and C5b-9 in ALS patient blood

Mantovani, S., Gordon, R., Macmaw, J. K., Plfluger, C. M., Henderson, R. D., Noakes, P. G., McCombe, P. A. and Woodruff, T. M. (2014). Elevation of the terminal complement activation products C5a and C5b-9 in ALS patient blood. Journal of Neuroimmunology, 276 (1-2), 213-218. doi: 10.1016/j.jneuroim.2014.09.005

Proteolytic activation of proapoptotic kinase protein kinase Cδ by tumor necrosis factor α death receptor signaling in dopaminergic neurons during neuroinflammation

Gordon, Richard, Anantharam, Vellareddy, Kanthasamy, Anumantha G. and Kanthasamy, Arthi (2012). Proteolytic activation of proapoptotic kinase protein kinase Cδ by tumor necrosis factor α death receptor signaling in dopaminergic neurons during neuroinflammation. Journal of Neuroinflammation, 9 (1) 82. doi: 10.1186/1742-2094-9-82

Neuroprotective Effect of Resveratrol Against Methamphetamine-Induced Dopaminergic Apoptotic Cell Death in a Cell Culture Model of Neurotoxicity

Kanthasamy, Kavin, Gordon, Richard, Jin, Huajun, Anantharam, Vellareddy, Ali, Syed, Kanthasamy, Anumantha G. and Kanthasamy, Arthi (2011). Neuroprotective Effect of Resveratrol Against Methamphetamine-Induced Dopaminergic Apoptotic Cell Death in a Cell Culture Model of Neurotoxicity. Current Neuropharmacology, 9 (1), 49-53. doi: 10.2174/157015911795017353

A simple magnetic separation method for high-yield isolation of pure primary microglia

Gordon, Richard, Hogan, Colleen E., Neal, Matthew L., Anantharam, Vellareddy, Kanthasamy, Anumantha G. and Kanthasamy, Arthi (2011). A simple magnetic separation method for high-yield isolation of pure primary microglia. Journal of Neuroscience Methods, 194 (2), 287-296. doi: 10.1016/j.jneumeth.2010.11.001

A Novel Role for Glucocerebrosidase 1 (GBA1) in Parkinson's Disease

Jayabalan, Nanthini, Roper, Katherine Kerry, Woodhouse, Helen M., Adam, Robert J., O'Sullivan, John D. and Gordon, Richard (2022). A Novel Role for Glucocerebrosidase 1 (GBA1) in Parkinson's Disease. Experimental Biology Meeting 2022, Philadelphia, PA United States, 2-5 April 2022. Hoboken, NJ United States: John Wiley and Sons. doi: 10.1096/fasebj.2022.36.S1.R5391

C5aR1 is required for a-synuclein mediated NLRP3 inflammasome activation

Gordon, Richard, Albornoz, Eduardo, Kanthasamy, Anumantha and Woodruff, Trent (2018). C5aR1 is required for a-synuclein mediated NLRP3 inflammasome activation. 27th International Complement Workshop (ICW), Santa Fe, NM, United States, Sep 16-20, 2018. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2018.06.247

Gut microbiome changes induced by experimental trichuris muris infection are associated with decreased cognitive function in mice

Magalhaes, Ricardo J. Soares, Giacomin, Paul, Sarnyay, Zoltan, Kraeuter, Ann, Urich, Tim, Bengtsson, Mia, Jin, Shuting, Albornoz, Eduardo A., Gordon, Richard and Woodruff, Trent (2017). Gut microbiome changes induced by experimental trichuris muris infection are associated with decreased cognitive function in mice. 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Atlanta, GA, United States, 13-16 November 2016. Deerfield, United States: American Society of Tropical Medicine and Hygiene.

Motor neuron disease proteins activate complement and generate C5a

Deora, Vandana, Mantovani, Susanna, Yerbury, Justin, Clark, Richard, Atkin, Julie, Lee, John, Gordon, Richard and Woodruff, Trent M. (2017). Motor neuron disease proteins activate complement and generate C5a. 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen, Denmark, 8-12 September 2017. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2017.06.144

A pathogenic role for the C5a receptor, C5aR2, in mouse models of Huntington's and Parkinson's disease

Li, Rui, Lee, John D., Levin, Samantha, Gordon, Richard and Woodruff, Trent M. (2016). A pathogenic role for the C5a receptor, C5aR2, in mouse models of Huntington's and Parkinson's disease. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2016.06.186

Complement C5a activates microglial NLRP3 inflammasomes and drives neurodegeneration in Parkinson's disease through C5aR1

Gordon, Richard, Albornoz, Eduardo A., Kumar, Vinod, Zhou, Kiane, Garin-Michaud, Ashoka, Mantavani, Susanna, Kanthasamy, Anumantha G. and Woodruff, Trent M. (2016). Complement C5a activates microglial NLRP3 inflammasomes and drives neurodegeneration in Parkinson's disease through C5aR1. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2016.06.146

The complement C5a receptor, C5aR2 contributes to motor deficits in mouse models of Huntington's and Parkinson's disease

Li, R., Levin, S., Lee, J., Gordon, R. and Woodruff, T. (2016). The complement C5a receptor, C5aR2 contributes to motor deficits in mouse models of Huntington's and Parkinson's disease. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200

Paraquat activates the NLRP3 Inflammasome in microglia via the NADPH oxidase pathway

Albornoz, E., Deora, V., Robertson, B. A., Cooper, M. A., Schroder, K., Woodruff, T. M. and Gordon, R. (2015). Paraquat activates the NLRP3 Inflammasome in microglia via the NADPH oxidase pathway. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley-Blackwell.

Peripheral immune complement activation in neurodegenerative disease

Mantovani, S., Gordon, R., Ngo, S., Pfluger, C., O'Sullivan, J., Noakes, P., Henderson, R., McCombe, P. and Woodruff, T. (2015). Peripheral immune complement activation in neurodegenerative disease. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/jnc.13188

Behavioural and pathological phenotyping of the C57BL/6J BACHD transgenic mouse model of Huntington’s disease

Mantovani, S., Li, R., Gordon, R., Kumar, V., Taylor, S. and Woodruff, T. M. (2013). Behavioural and pathological phenotyping of the C57BL/6J BACHD transgenic mouse model of Huntington’s disease. World Congress on Huntington’s disease, Rio de Janeiro, Brazil, 15-18 September 2013. Amsterdam, Netherlands: I O S Press.