Overview
Qualifications
- Doctor of Philosophy, Queensland University of Technology
- Masters (Research), Utrecht University
- Bachelor (Honours) of Psychological Science, The University of Queensland
Publications
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Journal Article: Assessing the impact of risk-based data monitoring on outcomes for a paediatric multicentre randomised controlled trial
Le Marsney, Renate, Johnson, Kerry, Chumbes Flores, Jenipher, Coetzer, Shelley, Darvas, Jennifer, Delzoppo, Carmel, Jolly, Arielle, Masterson, Kate, Sherring, Claire, Thomson, Hannah, Ergetu, Endrias, Gilholm, Patricia and Gibbons, Kristen S (2024). Assessing the impact of risk-based data monitoring on outcomes for a paediatric multicentre randomised controlled trial. Clinical Trials, 17407745231222019. doi: 10.1177/17407745231222019
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Journal Article: Post-traumatic stress and health-related quality of life after admission to paediatric intensive care: Longitudinal associations in mother–child dyads
Long, Debbie A., Gilholm, Patricia, Le Brocque, Robyne, Kenardy, Justin, Gibbons, Kristen and Dow, Belinda L. (2023). Post-traumatic stress and health-related quality of life after admission to paediatric intensive care: Longitudinal associations in mother–child dyads. Australian Critical Care, 37 (1), 98-105. doi: 10.1016/j.aucc.2023.10.004
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Journal Article: Adaptive clinical trials in pediatric critical care: a systematic review
Gilholm, Patricia, Ergetu, Endrias, Gelbart, Ben, Raman, Sainath, Festa, Marino, Schlapbach, Luregn J., Long, Debbie, Gibbons, Kristen S. and on behalf of the Australian and New Zealand Intensive Care Society Paediatric Study Group (2023). Adaptive clinical trials in pediatric critical care: a systematic review. Pediatric Critical Care Medicine, 24 (9), 738-749. doi: 10.1097/pcc.0000000000003273
Grants
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(2023–2025) ZOLL Foundation Grants
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Visiting Fellowship in Clinical Trial Methodology
(2023) Visiting Fellowship in Clinical Trial Methodology
Available Projects
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Survey of barriers and facilitators to implementation of adaptive clinical trials in paediatric critical care
This project aims to explore the barriers and facilitators to implementation of adaptive trial designs, a more flexible approach to clinical trials, in paediatric critical care. Traditional randomised controlled trials (RCTs) can be time-consuming and require a large number of patients, but adaptive designs offer a more efficient and cost-effective alternative. However, despite these benefits, only a small percentage of paediatric critical care trials have adopted adaptive designs. For this project, a survey and interviews with trialists will be conducted to identify the barriers and facilitators to using adaptive designs in this field, with the goal of understanding how to successfully implement these innovative trial approaches.
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Educational outcomes of PICU sepsis survivors in Queensland
Sepsis is a dangerous condition in children caused by the body's response to infection, which can lead to organ problems and even death if not treated quickly. Children who survive sepsis may face ongoing educational difficulties, such as trouble learning, cognitive issues, and struggles in school. To better understand the long-term effects, this project will use data from a 20-year period, linking information about sepsis survivors in paediatric intensive care units (PICU) with standardised educational assessments in Queensland. The results will help inform support programs for this vulnerable group, ensuring they receive the necessary help to succeed in their education.
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Impact of PICU admission on school performance for Queensland school-aged children: a pre-post study
Our team has developed a machine learning model to predict poor school outcomes in children who survived the intensive care unit (ICU). We used data from over 13,000 childhood ICU survivors in Queensland, Australia, over a 22-year period. The model showed promising results with an ability to predict school performance based on data available at the time of ICU discharge, which could help prioritise patients for follow-up care and target rehabilitation efforts. However, most children who are admitted to ICU are admitted prior to school-age, which limited our ability to assess more immediate effects of ICU admission on children’s educational performance. This project will focus on the school performance of school aged PICU survivors, and will assess the change in educational performance before and after a PICU admission.
Publications
Journal Article
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Le Marsney, Renate, Johnson, Kerry, Chumbes Flores, Jenipher, Coetzer, Shelley, Darvas, Jennifer, Delzoppo, Carmel, Jolly, Arielle, Masterson, Kate, Sherring, Claire, Thomson, Hannah, Ergetu, Endrias, Gilholm, Patricia and Gibbons, Kristen S (2024). Assessing the impact of risk-based data monitoring on outcomes for a paediatric multicentre randomised controlled trial. Clinical Trials, 17407745231222019. doi: 10.1177/17407745231222019
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Long, Debbie A., Gilholm, Patricia, Le Brocque, Robyne, Kenardy, Justin, Gibbons, Kristen and Dow, Belinda L. (2023). Post-traumatic stress and health-related quality of life after admission to paediatric intensive care: Longitudinal associations in mother–child dyads. Australian Critical Care, 37 (1), 98-105. doi: 10.1016/j.aucc.2023.10.004
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Adaptive clinical trials in pediatric critical care: a systematic review
Gilholm, Patricia, Ergetu, Endrias, Gelbart, Ben, Raman, Sainath, Festa, Marino, Schlapbach, Luregn J., Long, Debbie, Gibbons, Kristen S. and on behalf of the Australian and New Zealand Intensive Care Society Paediatric Study Group (2023). Adaptive clinical trials in pediatric critical care: a systematic review. Pediatric Critical Care Medicine, 24 (9), 738-749. doi: 10.1097/pcc.0000000000003273
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Gilholm, Patricia, Gibbons, Kristen, Brüningk, Sarah, Klatt, Juliane, Vaithianathan, Rhema, Long, Debbie, Millar, Johnny, Tomaszewski, Wojtek, Schlapbach, Luregn J., Ganeshalingam, Anusha, Sherring, Claire, Erickson, Simon, Barr, Samantha, Raman, Sainath, Long, Debbie, Schlapbach, Luregn, Gibbons, Kristen, George, Shane, Singh, Puneet, Smith, Vicky, Butt, Warwick, Delzoppo, Carmel, Millar, Johnny, Gelbart, Ben, Oberender, Felix, Ganu, Subodh, Letton, Georgia, Festa, Marino, Harper, Gail and the Australian and New Zealand Intensive Care Society (ANZICS) Centre for Outcomes & Resource Evaluation (CORE) and ANZICS Paediatric Study Group (ANZICS PSG) (2023). Machine learning to predict poor school performance in paediatric survivors of intensive care: a population-based cohort study. Intensive Care Medicine, 49 (7), 785-795. doi: 10.1007/s00134-023-07137-1
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Sever, Zoe, Schlapbach, Luregn J., Gilholm, Patricia, Jessup, Melanie, Phillips, Natalie, George, Shane, Gibbons, Kristen and Harley, Amanda (2023). Impact of parental and healthcare professional concern on the diagnosis of pediatric sepsis: a diagnostic accuracy study. Frontiers in Pediatrics, 11 1140121, 1140121. doi: 10.3389/fped.2023.1140121
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Gilholm, Patricia, Gibbons, Kristen, Lister, Paula, Harley, Amanda, Irwin, Adam, Raman, Sainath, Rice, Michael, Schlapbach, Luregn J. and Queensland Statewide Sepsis Collaborative (2023). Validation of a paediatric sepsis screening tool to identify children with sepsis in the emergency department: a statewide prospective cohort study in Queensland, Australia. BMJ Open, 13 (1) e061431, 1-25. doi: 10.1136/bmjopen-2022-061431
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The current and future state of pediatric sepsis definitions: an international survey
Morin, Luc, Hall, Mark, de Souza, Daniela, Guoping, Lu, Jabornisky, Roberto, Shime, Nobuaki, Ranjit, Suchitra, Gilholm, Patricia, Nakagawa, Satoshi, Zimmerman, Jerry J., Sorce, Lauren R., Argent, Andrew, Kissoon, Niranjan, Tissières, Pierre, Watson, R. Scott and Schlapbach, Luregn J (2022). The current and future state of pediatric sepsis definitions: an international survey. Pediatrics, 149 (6) ARTN e2021052565. doi: 10.1542/peds.2021-052565
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Harley, Amanda, Lister, Paula, Gilholm, Patricia, Rice, Michael, Venkatesh, Bala, Johnston, Amy N.B., Massey, Debbie, Irwin, Adam, Gibbons, Kristen and Schlapbach, Luregn J. (2021). Queensland Pediatric Sepsis Breakthrough Collaborative: Multicenter Observational Study to Evaluate the Implementation of a Pediatric Sepsis Pathway Within the Emergency Department. Critical Care Explorations, 3 (11) e0573, 1-14. doi: 10.1097/cce.0000000000000573
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Harley, Amanda, Schlapbach, Luregn J., Lister, Paula, Massey, Debbie, Gilholm, Patricia and Johnston, Amy N. B. (2021). Knowledge translation following the implementation of a state-wide Paediatric Sepsis Pathway in the emergency department- a multi-centre survey study. BMC Health Services Research, 21 (1) 1161, 1161. doi: 10.1186/s12913-021-07128-2
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Gilholm, Patricia, Mengersen, Kerrie and Thompson, Helen (2021). Bayesian hierarchical multidimensional item response modeling of small sample, sparse data for personalized developmental surveillance. Educational and Psychological Measurement, 81 (5), 936-956. doi: 10.1177/0013164420987582
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Gilholm, Patricia, Mengersen, Kerrie and Thompson, Helen (2020). Identifying latent subgroups of children with developmental delay using Bayesian sequential updating and Dirichlet process mixture modelling. PLoS One, 15 (6) e0233542, 1-17. doi: 10.1371/journal.pone.0233542
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Vermande, Marjolijn M., Gilholm, Patricia A., Reijntjes, Albert H. A., Hessen, Dave J., Sterck, Elisabeth H. M. and Overduin-de Vries, Anne M. (2018). Is inspiring group members an effective predictor of social dominance in early adolescence? direct and moderated effects of behavioral strategies, social skills, and gender on resource control and popularity. Journal of Youth and Adolescence, 47 (9), 1813-1829. doi: 10.1007/s10964-018-0830-9
Conference Publication
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Gilholm, P., Irwin, A., Lister, P., Harley, A., Raman, S., Schlapbach, L. J. and Gibbons, K. (2022). Identifying clinical symptom profiles for sepsis in children screened for sepsis on admission to the emergency department. 11th Congress of the World Federation of Pediatric Intensive & Critical Care Societies, Online, 12-16 July 2022. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1097/01.pcc.0000899876.46317.ec
Grants (Administered at UQ)
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(2023–2025) ZOLL Foundation Grants
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Visiting Fellowship in Clinical Trial Methodology
(2023) Visiting Fellowship in Clinical Trial Methodology
Possible Research Projects
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
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Survey of barriers and facilitators to implementation of adaptive clinical trials in paediatric critical care
This project aims to explore the barriers and facilitators to implementation of adaptive trial designs, a more flexible approach to clinical trials, in paediatric critical care. Traditional randomised controlled trials (RCTs) can be time-consuming and require a large number of patients, but adaptive designs offer a more efficient and cost-effective alternative. However, despite these benefits, only a small percentage of paediatric critical care trials have adopted adaptive designs. For this project, a survey and interviews with trialists will be conducted to identify the barriers and facilitators to using adaptive designs in this field, with the goal of understanding how to successfully implement these innovative trial approaches.
-
Educational outcomes of PICU sepsis survivors in Queensland
Sepsis is a dangerous condition in children caused by the body's response to infection, which can lead to organ problems and even death if not treated quickly. Children who survive sepsis may face ongoing educational difficulties, such as trouble learning, cognitive issues, and struggles in school. To better understand the long-term effects, this project will use data from a 20-year period, linking information about sepsis survivors in paediatric intensive care units (PICU) with standardised educational assessments in Queensland. The results will help inform support programs for this vulnerable group, ensuring they receive the necessary help to succeed in their education.
-
Impact of PICU admission on school performance for Queensland school-aged children: a pre-post study
Our team has developed a machine learning model to predict poor school outcomes in children who survived the intensive care unit (ICU). We used data from over 13,000 childhood ICU survivors in Queensland, Australia, over a 22-year period. The model showed promising results with an ability to predict school performance based on data available at the time of ICU discharge, which could help prioritise patients for follow-up care and target rehabilitation efforts. However, most children who are admitted to ICU are admitted prior to school-age, which limited our ability to assess more immediate effects of ICU admission on children’s educational performance. This project will focus on the school performance of school aged PICU survivors, and will assess the change in educational performance before and after a PICU admission.
