The University of Queensland

Preclassification of broadband and sparse infrared data by multiplicative signal correction approach

Rehman, Hafeez Ur, Tafintseva, Valeria, Zimmermann, Boris, Solheim, Johanne Heitmann, Virtanen, Vesa, Shaikh, Rubina, Nippolainen, Ervin, Afara, Isaac, Saarakkala, Simo, Rieppo, Lassi, Krebs, Patrick, Fomina, Polina, Mizaikoff, Boris and Kohler, Achim (2022). Preclassification of broadband and sparse infrared data by multiplicative signal correction approach. Molecules, 27 (7) 2298. doi: 10.3390/molecules27072298

Near infrared spectroscopic evaluation of biochemical and crimp properties of knee joint ligaments and patellar tendon

Torniainen, Jari, Ristaniemi, Aapo, Sarin, Jaakko K., Prakash, Mithilesh, Afara, Isaac O., Finnilä, Mikko A.J., Stenroth, Lauri, Korhonen, Rami K. and Töyräs, Juha (2022). Near infrared spectroscopic evaluation of biochemical and crimp properties of knee joint ligaments and patellar tendon. PLoS ONE, 17 (2) e0263280. doi: 10.1371/journal.pone.0263280

Preprocessing strategies for sparse infrared spectroscopy: a case study on cartilage diagnostics

Tafintseva, Valeria, Lintvedt, Tiril Aurora, Solheim, Johanne Heitmann, Zimmermann, Boris, Rehman, Hafeez Ur, Virtanen, Vesa, Shaikh, Rubina, Nippolainen, Ervin, Afara, Isaac, Saarakkala, Simo, Rieppo, Lassi, Krebs, Patrick, Fomina, Polina, Mizaikoff, Boris and Kohler, Achim (2022). Preprocessing strategies for sparse infrared spectroscopy: a case study on cartilage diagnostics. Molecules, 27 (3) 873. doi: 10.3390/molecules27030873

Resolving the near-infrared spectrum of articular cartilage

Afara, Isaac O. and Oloyede, Adekunle (2021). Resolving the near-infrared spectrum of articular cartilage. Cartilage, 13 (1_suppl), 194760352110354-737S. doi: 10.1177/19476035211035417

Ultraviolet/visible and near-infrared dual spectroscopic method for detection and quantification of low-level malaria Parasitemia in whole blood

Adegoke, John A., De Paoli, Amanda, Afara, Isaac O., Kochan, Kamila, Creek, Darren J., Heraud, Philip and Wood, Bayden R. (2021). Ultraviolet/visible and near-infrared dual spectroscopic method for detection and quantification of low-level malaria Parasitemia in whole blood. Analytical Chemistry, 93 (39), 13302-13310. doi: 10.1021/acs.analchem.1c02948

High-resolution infrared microspectroscopic characterization of cartilage cell microenvironment

Linus, Awuniji, Ebrahimi, Mohammadhossein, Turunen, Mikael J., Saarakkala, Simo, Joukainen, Antti, Kröger, Heikki, Koistinen, Arto, Finnilä, Mikko A.J., Afara, Isaac O., Mononen, Mika E., Tanska, Petri and Korhonen, Rami K. (2021). High-resolution infrared microspectroscopic characterization of cartilage cell microenvironment. Acta Biomaterialia, 134, 252-260. doi: 10.1016/j.actbio.2021.08.001

Articular cartilage optical properties in the near-infrared (NIR) spectral range vary with depth and tissue integrity

Khan, Bilour, Kafian-Attari, Iman, Nippolainen, Ervin, Shaikh, Rubina, Semenov, Dmitry, Hauta-Kasari, Markku, Töyräs, Juha and Afara, Isaac O. (2021). Articular cartilage optical properties in the near-infrared (NIR) spectral range vary with depth and tissue integrity. Biomedical Optics Express, 12 (10), 6066-6080. doi: 10.1364/boe.430053

Raman spectroscopy is sensitive to biochemical changes related to various cartilage injuries

Shaikh, Rubina, Nippolainen, Ervin, Virtanen, Vesa, Torniainen, Jari, Rieppo, Lassi, Saarakkala, Simo, Afara, Isaac O. and Töyräs, Juha (2021). Raman spectroscopy is sensitive to biochemical changes related to various cartilage injuries. Journal of Raman Spectroscopy, 52 (4) jrs.6062, 796-804. doi: 10.1002/jrs.6062

Infrared fiber-optic spectroscopy detects bovine articular cartilage degeneration

Virtanen, Vesa, Nippolainen, Ervin, Shaikh, Rubina, Afara, Isaac O., Töyräs, Juha, Solheim, Johanne, Tafintseva, Valeria, Zimmermann, Boris, Kohler, Achim, Saarakkala, Simo and Rieppo, Lassi (2021). Infrared fiber-optic spectroscopy detects bovine articular cartilage degeneration. Cartilage, 13 (2_suppl), 1-10. doi: 10.1177/1947603521993221

Characterization of connective tissues using near-infrared spectroscopy and imaging

Afara, Isaac O., Shaikh, Rubina, Nippolainen, Ervin, Querido, William, Torniainen, Jari, Sarin, Jaakko K, Kandel, Shital, Pleshko, Nancy and Töyräs, Juha (2021). Characterization of connective tissues using near-infrared spectroscopy and imaging. Nature Protocols, 16 (2), 1297-1329. doi: 10.1038/s41596-020-00468-z

Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: A 9-month equine groove model study

Te Moller, Nikae C R, Mohammadi, Ali, Plomp, Saskia, Serra Bragança, Filipe M, Beukers, Martijn, Pouran, Behdad, Afara, Isaac O, Nippolainen, Ervin, Mäkelä, Janne T A, Korhonen, Rami K, Töyräs, Juha, Brommer, Harold and van Weeren, P René (2021). Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: A 9-month equine groove model study. Journal of Orthopaedic Research, 39 (11) jor.24971, 1-13. doi: 10.1002/jor.24971

Machine learning augmented near-infrared spectroscopy: in vivo follow-up of cartilage defects

Sarin, J. K., Te Moller, N. C. R., Mohammadi, A., Prakash, M., Torniainen, J., Brommer, H., Nippolainen, E., Shaikh, R., Mäkelä, J. T. A., Korhonen, R. K., van Weeren, P. R., Afara, I. O. and Töyräs, J. (2020). Machine learning augmented near-infrared spectroscopy: in vivo follow-up of cartilage defects. Osteoarthritis and Cartilage, 29 (3), 423-432. doi: 10.1016/j.joca.2020.12.007

Detailed assessment of sleep architecture with deep learning and shorter epoch-to-epoch duration reveals sleep fragmentation of patients with obstructive sleep apnea

Korkalainen, Henri, Leppanen, Timo, Duce, Brett, Kainulainen, Samu, Aakko, Juhani, Leino, Akseli, Kalevo, Laura, Afara, Isaac O, Myllymaa, Sami and Toyras, Juha (2020). Detailed assessment of sleep architecture with deep learning and shorter epoch-to-epoch duration reveals sleep fragmentation of patients with obstructive sleep apnea. IEEE Journal of Biomedical and Health Informatics, PP (7) 9288902, 1-8. doi: 10.1109/JBHI.2020.3043507

Tissue optical properties combined with machine learning enables estimation of articular cartilage composition and functional integrity

Kafian-Attari, Iman, Nippolainen, Ervin, Semenov, Dmitry, Hauta-Kasari, Markku, Töyräs, Juha and Afara, Isaac O. (2020). Tissue optical properties combined with machine learning enables estimation of articular cartilage composition and functional integrity. Biomedical Optics Express, 11 (11), 6480-6494. doi: 10.1364/BOE.402929

Power spectral densities of nocturnal pulse oximetry signals differ in OSA patients with and without daytime sleepiness

Kainulainen, Samu, Töyräs, Juha, Oksenberg, Arie, Korkalainen, Henri, Afara, Isaac O., Leino, Akseli, Kalevo, Laura, Nikkonen, Sami, Gadoth, Natan, Kulkas, Antti, Myllymaa, Sami and Leppänen, Timo (2020). Power spectral densities of nocturnal pulse oximetry signals differ in OSA patients with and without daytime sleepiness. Sleep Medicine, 73, 231-237. doi: 10.1016/j.sleep.2020.07.015

Quantification of myocardial blood flow by machine learning analysis of modified dual bolus MRI examination

Husso, Minna, Afara, Isaac O., Nissi, Mikko J., Kuivanen, Antti, Halonen, Paavo, Tarkia, Miikka, Teuho, Jarmo, Saunavaara, Virva, Vainio, Pauli, Sipola, Petri, Manninen, Hannu, Ylä-Herttuala, Seppo, Knuuti, Juhani and Töyräs, Juha (2020). Quantification of myocardial blood flow by machine learning analysis of modified dual bolus MRI examination. Annals of Biomedical Engineering, 49 (2), 653-662. doi: 10.1007/s10439-020-02591-0

Near-infrared spectroscopy for mapping of human meniscus biochemical constituents

Ala-Myllymäki, Juho, Paakkonen, Tommi, Joukainen, Antti, Kröger, Heikki, Lehenkari, Petri, Töyräs, Juha and Afara, Isaac O. (2020). Near-infrared spectroscopy for mapping of human meniscus biochemical constituents. Annals of Biomedical Engineering, 49 (1), 469-476. doi: 10.1007/s10439-020-02578-x

Accurate deep learning-based sleep staging in a clinical population with suspected obstructive sleep apnea

Korkalainen, Henri, Leppanen, Timo, Aakko, Juhani, Nikkonen, Sami, Kainulainen, Samu, Leino, Akseli, Duce, Brett, Afara, Isaac Oluwaseun, Myllymaa, Sami and Toyras, Juha (2020). Accurate deep learning-based sleep staging in a clinical population with suspected obstructive sleep apnea. IEEE Journal of Biomedical and Health Informatics, 24 (7) 8936942, 2073-2081. doi: 10.1109/JBHI.2019.2951346

Deep learning enables sleep staging from photoplethysmogram for patients with suspected sleep apnea

Korkalainen, Henri, Aakko, Juhani, Duce, Brett, Kainulainen, Samu, Leino, Akseli, Nikkonen, Sami, Afara, Isaac O., Myllymaa, Sami, Töyräs, Juha and Leppänen, Timo (2020). Deep learning enables sleep staging from photoplethysmogram for patients with suspected sleep apnea. Sleep, 43 (11) zsaa098. doi: 10.1093/sleep/zsaa098

Open-source python module for automated preprocessing of near infrared spectroscopic data

Torniainen, Jari, Afara, Isaac O., Prakash, Mithilesh, Sarin, Jaakko K., Stenroth, Lauri and Töyräs, Juha (2020). Open-source python module for automated preprocessing of near infrared spectroscopic data. Analytica Chimica Acta, 1108, 1-9. doi: 10.1016/j.aca.2020.02.030

Author Correction: Artificial neural network analysis of the oxygen saturation signal enables accurate diagnostics of sleep apnea (Scientific Reports, (2019), 9, 1, (13200), 10.1038/s41598-019-49330-7)

Nikkonen, Sami, Afara, Isaac O., Leppänen, Timo and Töyräs, Juha (2020). Author Correction: Artificial neural network analysis of the oxygen saturation signal enables accurate diagnostics of sleep apnea (Scientific Reports, (2019), 9, 1, (13200), 10.1038/s41598-019-49330-7). Scientific Reports, 10 (1) 4977, 4977. doi: 10.1038/s41598-020-62003-0

Machine learning classification of articular cartilage integrity using near infrared spectroscopy

Afara, Isaac O., Sarin, Jaakko K., Ojanen, Simo, Finnilä, Mikko A. J., Herzog, Walter, Saarakkala, Simo, Korhonen, Rami K. and Töyräs, Juha (2020). Machine learning classification of articular cartilage integrity using near infrared spectroscopy. Cellular and Molecular Bioengineering, 13 (3), 219-228. doi: 10.1007/s12195-020-00612-5

Near infrared spectroscopy enables differentiation of mechanically and enzymatically induced cartilage injuries

Nippolainen, Ervin, Shaikh, Rubina, Virtanen, Vesa, Rieppo, Lassi, Saarakkala, Simo, Töyräs, Juha and Afara, Isaac O. (2020). Near infrared spectroscopy enables differentiation of mechanically and enzymatically induced cartilage injuries. Annals of Biomedical Engineering, 48 (9), 2343-2353. doi: 10.1007/s10439-020-02506-z

Impact of nanoparticle uptake on the biophysical properties of cell for biomedical engineering applications

Rasel, Md Alim Iftekhar, Singh, Sanjleena, Nguyen, Trung Dung, Afara, Isaac O. and Gu, Yuantong (2019). Impact of nanoparticle uptake on the biophysical properties of cell for biomedical engineering applications. Scientific Reports, 9 (1) 5859, 1-13. doi: 10.1038/s41598-019-42225-7

Effects of body mass on microstructural features of the osteochondral unit: A comparative analysis of 37 mammalian species

Mancini, I. A.D., Rieppo, L., Pouran, B., Afara, I. O., Braganca, F.M. Serra, van Rijen, M. H.P., Kik, M., Weinans, H., Toyras, J., van Weeren, P. R. and Malda, J. (2019). Effects of body mass on microstructural features of the osteochondral unit: A comparative analysis of 37 mammalian species. Bone, 127, 664-673. doi: 10.1016/j.bone.2019.07.001

Artificial neural network analysis of the oxygen saturation signal enables accurate diagnostics of sleep apnea

Nikkonen, Sami, Afara, Isaac O., Leppänen, Timo and Töyräs, Juha (2019). Artificial neural network analysis of the oxygen saturation signal enables accurate diagnostics of sleep apnea. Scientific Reports, 9 (1) 13200, 13200. doi: 10.1038/s41598-019-49330-7

Dataset on equine cartilage near infrared spectra, composition, and functional properties

Sarin, Jaakko K., Torniainen, Jari, Prakash, Mithilesh, Rieppo, Lassi, Afara, Isaac O. and Toyras, Juha (2019). Dataset on equine cartilage near infrared spectra, composition, and functional properties. Scientific Data, 6 (1) 164, 164. doi: 10.1038/s41597-019-0170y

Arthroscopic determination of cartilage proteoglycan content and collagen network structure with near-infrared spectroscopy

Sarin, Jaakko K., Nykänen, Olli, Tiitu, Virpi, Mancini, Irina A. D., Brommer, Harold, Visser, Jetze, Malda, Jos, van Weeren, P. René, Afara, Isaac O. and Töyräs, Juha (2019). Arthroscopic determination of cartilage proteoglycan content and collagen network structure with near-infrared spectroscopy. Annals of Biomedical Engineering, 47 (8), 1815-1826. doi: 10.1007/s10439-019-02280-7

Near-infrared spectroscopy enables quantitative evaluation of human cartilage biomechanical properties during arthroscopy

Prakash, M., Joukainen, A., Torniainen, J., Honkanen, M. K.M., Rieppo, L., Afara, I. O., Kröger, H., Töyräs, J. and Sarin, J. K. (2019). Near-infrared spectroscopy enables quantitative evaluation of human cartilage biomechanical properties during arthroscopy. Osteoarthritis and Cartilage, 27 (8), 1235-1243. doi: 10.1016/j.joca.2019.04.008

Near infrared spectroscopic evaluation of ligament and tendon biomechanical properties

Torniainen, Jari, Ristaniemi, Aapo, Sarin, Jaakko K., Mikkonen, Santtu, Afara, Isaac O., Stenroth, Lauri, Korhonen, Rami K. and Töyräs, Juha (2019). Near infrared spectroscopic evaluation of ligament and tendon biomechanical properties. Annals of Biomedical Engineering, 47 (1), 213-222. doi: 10.1007/s10439-018-02125-9

Accounting for spatial dependency in multivariate spectroscopic data

Prakash, M., Sarin, J. K., Rieppo, L., Afara, I. O. and Töyräs, J. (2018). Accounting for spatial dependency in multivariate spectroscopic data. Chemometrics and Intelligent Laboratory Systems, 182, 166-171. doi: 10.1016/j.chemolab.2018.09.010

Arthroscopic near infrared spectroscopy enables simultaneous quantitative evaluation of articular cartilage and subchondral bone in vivo

Sarin, Jaakko K., te Moller, Nikae C. R., Mancini, Irina A. D., Brommer, Harold, Visser, Jetze, Malda, Jos, van Weeren, P. René, Afara, Isaac O. and Töyräs, Juha (2018). Arthroscopic near infrared spectroscopy enables simultaneous quantitative evaluation of articular cartilage and subchondral bone in vivo. Scientific Reports, 8 (1) 13409, 13409. doi: 10.1038/s41598-018-31670-5

Characterizing human subchondral bone properties using near-infrared (NIR) spectroscopy

Afara, Isaac O., Florea, Cristina, Olumegbon, Ismail A., Eneh, Chibuzor T., Malo, Markus K. H., Korhonen, Rami K. and Töyräs, Juha (2018). Characterizing human subchondral bone properties using near-infrared (NIR) spectroscopy. Scientific Reports, 8 (1) 9733, 9733. doi: 10.1038/s41598-018-27786-3

Potential enhancement of articular cartilage histological grading with collagen integrity

Moody, Hayley R., Afara, Isaac O., Singh, Sanjleena and Oloyede, Adekunle (2018). Potential enhancement of articular cartilage histological grading with collagen integrity. Clinical Biomechanics, 56, 1-10. doi: 10.1016/j.clinbiomech.2018.04.016

A new mechanical indentation framework for functional assessment of articular cartilage

Arabshahi, Zohreh, Afara, Isaac Oluwaseun, Moody, Hayley Ruscoe, Schrobback, Karsten, Kashani, Jamal, Fischer, Nadine, Oloyede, Adekunle and Klein, Travis Jacob (2018). A new mechanical indentation framework for functional assessment of articular cartilage. Journal of the Mechanical Behavior of Biomedical Materials, 81, 83-94. doi: 10.1016/j.jmbbm.2018.02.028

Optical spectroscopic characterization of human meniscus biomechanical properties

Ala-Myllymäki, Juho, Danso, Elvis K., Honkanen, Juuso T. J., Korhonen, Rami K., Toÿräs, Juha and Afara, Isaac O. (2017). Optical spectroscopic characterization of human meniscus biomechanical properties. Journal of Biomedical Optics, 22 (12) 125008. doi: 10.1117/1.JBO.22.12.125008

Monitoring osteoarthritis progression using near infrared (NIR) spectroscopy

Afara, Isaac O., Prasadam, Indira, Arabshahi, Zohreh, Xiao, Yin and Oloyede, Adekunle (2017). Monitoring osteoarthritis progression using near infrared (NIR) spectroscopy. Scientific Reports, 7 (1) 11463, 1-9. doi: 10.1038/s41598-017-11844-3

Optimal regression method for near-infrared spectroscopic evaluation of articular cartilage

Prakash, Mithilesh, Sarin, Jaakko K., Rieppo, Lassi, Afara, Isaac O. and Töyräs, Juha (2017). Optimal regression method for near-infrared spectroscopic evaluation of articular cartilage. Applied Spectroscopy, 71 (10), 2253-2262. doi: 10.1177/0003702817726766

Combination of optical coherence tomography and near infrared spectroscopy enhances determination of articular cartilage composition and structure

Sarin, Jaakko K., Rieppo, Lassi, Brommer, Harold, Afara, Isaac O., Saarakkala, Simo and Töyräs, Juha (2017). Combination of optical coherence tomography and near infrared spectroscopy enhances determination of articular cartilage composition and structure. Scientific Reports, 7 (1) 10586, 10586. doi: 10.1038/s41598-017-10973-z

Corrigendum to “Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo” [Osteoarthritis Cartilage 25 (5) (2017 May) 790–798] (S1063458416304666), (10.1016/j.joca.2016.12.007))

Sarin, J. K., Brommer, H., Argüelles, D., Puhakka, P. H., Inkinen, S. I., Afara, I. O., Saarakkala, S. and Töyräs, J. (2017). Corrigendum to “Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo” [Osteoarthritis Cartilage 25 (5) (2017 May) 790–798] (S1063458416304666), (10.1016/j.joca.2016.12.007)). Osteoarthritis and Cartilage, 25 (8), 1377-1378. doi: 10.1016/j.joca.2017.05.010

Near-infrared (NIR) spectroscopic evaluation of articular cartilage: A review of current and future trends

Olumegbon, Ismail Adewale, Oloyede, Adekunle and Afara, Isaac Oluwaseun (2017). Near-infrared (NIR) spectroscopic evaluation of articular cartilage: A review of current and future trends. Applied Spectroscopy Reviews, 52 (6), 541-559. doi: 10.1080/05704928.2016.1250010

Characterization of articular cartilage recovery and its correlation with optical response in the near-infrared spectral range

Afara, Isaac Oluwaseun, Singh, Sanjleena, Moody, Hayley, Zhang, Lihai and Oloyede, Adekunle (2017). Characterization of articular cartilage recovery and its correlation with optical response in the near-infrared spectral range. Cartilage, 8 (3), 307-316. doi: 10.1177/1947603516662502

Semi-automated International Cartilage Repair Society scoring of equine articular cartilage lesions in optical coherence tomography images

te Moller, N. C.R., Pitkänen, M., Sarin, J. K., Väänänen, S., Liukkonen, J., Afara, I. O., Puhakka, P. H., Brommer, H., Niemelä, T., Tulamo, R. M., Argüelles Capilla, D. and Töyräs, J. (2017). Semi-automated International Cartilage Repair Society scoring of equine articular cartilage lesions in optical coherence tomography images. Equine Veterinary Journal, 49 (4), 552-558. doi: 10.1111/evj.12637

Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo

Sarin, J. K., Brommer, H., Argüelles, D., Puhakka, P. H., Inkinen, S. I., Afara, I. O., Saarakkala, S. and Töyräs, J. (2017). Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo. Osteoarthritis and Cartilage, 25 (5), 790-798. doi: 10.1016/j.joca.2016.12.007

Bactericidal effects of natural nanotopography of dragonfly wing on Escherichia coli

Bandara, Chaturanga D., Singh, Sanjleena, Afara, Isaac O., Wolff, Annalena, Tesfamichael, Tuquabo, Ostrikov, Kostya and Oloyede, Adekunle (2017). Bactericidal effects of natural nanotopography of dragonfly wing on Escherichia coli. ACS Applied Materials and Interfaces, 9 (8), 6746-6760. doi: 10.1021/acsami.6b13666

Porosity predicted from ultrasound backscatter using multivariate analysis can improve accuracy of cortical bone thickness assessment

Eneh, Chibuzor T. M., Afara, Isaac O., Malo, Markus K. H., Jurvelin, Jukka S. and Töyräs, Juha (2017). Porosity predicted from ultrasound backscatter using multivariate analysis can improve accuracy of cortical bone thickness assessment. Journal of the Acoustical Society of America, 141 (1), 575-585. doi: 10.1121/1.4973572

Near infrared spectroscopic mapping of functional properties of equine articular cartilage

Sarin, Jaakko K., Amissah, Michael, Brommer, Harold, Argüelles, David, Töyräs, Juha and Afara, Isaac O. (2016). Near infrared spectroscopic mapping of functional properties of equine articular cartilage. Annals of Biomedical Engineering, 44 (11), 3335-3345. doi: 10.1007/s10439-016-1659-6

In vivo evaluation of the potential of high-frequency ultrasound for arthroscopic examination of the shoulder joint

Puhakka, Jani, Afara, Isaac O., Paatela, Teemu, Sormaala, Markus J., Timonen, Matti A., Virén, Tuomas, Jurvelin, Jukka S., Töyräs, Juha and Kiviranta, Ilkka (2016). In vivo evaluation of the potential of high-frequency ultrasound for arthroscopic examination of the shoulder joint. Cartilage, 7 (3), 248-255. doi: 10.1177/1947603515617280

Optical spectroscopic determination of human meniscus composition

Ala-Myllymäki, Juho, Honkanen, Juuso T.J., Töyräs, Juha and Afara, Isaac O. (2016). Optical spectroscopic determination of human meniscus composition. Journal of Orthopaedic Research, 34 (2), 270-278. doi: 10.1002/jor.23025

Tribological efficacy and stability of phospholipid-based membrane lubricants in varying ph chemical conditions

Pawlak, Zenon, Urbaniak, Wieslaw, Afara, Isaac O., Yusuf, Kehinde Q., Banaszak-Piechowska, Agnieszka and Oloyede, Adekunle (2016). Tribological efficacy and stability of phospholipid-based membrane lubricants in varying ph chemical conditions. Biointerphases, 11 (1) 019002, 1-5. doi: 10.1116/1.4939246

Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal

Puhakka, P. H., te Moller, N. C.R., Afara, I. O., Mäkelä, J. T.A., Tiitu, V., Korhonen, R. K., Brommer, H., Virén, T., Jurvelin, J. S. and Töyräs, J. (2015). Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal. Osteoarthritis and Cartilage, 23 (12), 2206-2213. doi: 10.1016/j.joca.2015.05.034

Effect of decellularization on the load-bearing characteristics of articular cartilage matrix

Singh, Sanjleena, Afara, Isaac O., Tehrani, Ashkan H. and Oloyede, Adekunle (2015). Effect of decellularization on the load-bearing characteristics of articular cartilage matrix. Tissue Engineering and Regenerative Medicine, 12 (5), 294-305. doi: 10.1007/s13770-014-0083-y

Optical absorption spectra of human articular cartilage correlate with biomechanical properties, histological score and biochemical composition

Afara, Isaac O., Hauta-Kasari, Markku, Jurvelin, Jukka S., Oloyede, Adekunle and Töyräs, Juha (2015). Optical absorption spectra of human articular cartilage correlate with biomechanical properties, histological score and biochemical composition. Physiological Measurement, 36 (9) 1913, 1913-1928. doi: 10.1088/0967-3334/36/9/1913

Spatial mapping of proteoglycan content in articular cartilage using near-infrared (NIR) spectroscopy

Afara, Isaac O., Moody, Hayley, Singh, Sanjleena, Prasadam, Indira and Oloyede, Adekunle (2015). Spatial mapping of proteoglycan content in articular cartilage using near-infrared (NIR) spectroscopy. Biomedical Optics Express, 6 (1), 144-154. doi: 10.1364/BOE.6.000144

Near infrared spectroscopy for rapid determination of Mankin score components: a potential tool for quantitative characterization of articular cartilage at surgery

Afara, Isaac Oluwaseun, Prasadam, Indira, Moody, Hayley, Crawford, Ross, Xiao, Yin and Oloyede, Adekunle (2014). Near infrared spectroscopy for rapid determination of Mankin score components: a potential tool for quantitative characterization of articular cartilage at surgery. Arthroscopy: The Journal of Arthroscopy and Related Surgery, 30 (9), 1146-1155. doi: 10.1016/j.arthro.2014.04.097

Biomaterial scaffolds in cartilage-subchondral bone defects influencing the repair of autologous articular cartilage transplants

Fan, Wei, Wu, Chengtie, Miao, Xigeng, Liu, Gang, Saifzadeh, Siamak, Sugiyama, Sadahiro, Afara, Isaac, Crawford, Ross and Xiao, Yin (2013). Biomaterial scaffolds in cartilage-subchondral bone defects influencing the repair of autologous articular cartilage transplants. Journal of Biomaterials Applications, 27 (8), 979-989. doi: 10.1177/0885328211431310

Load-unloading response of intact and artificially degraded articular cartilage correlated with near infrared (NIR) absorption spectra

Afara, I. O., Singh, S. and Oloyede, A. (2013). Load-unloading response of intact and artificially degraded articular cartilage correlated with near infrared (NIR) absorption spectra. Journal of the Mechanical Behavior of Biomedical Materials, 20, 249-258. doi: 10.1016/j.jmbbm.2012.11.022

Near infrared (NIR) absorption spectra correlates with subchondral bone micro-CT parameters in osteoarthritic rat models

Afara, Isaac Oluwaseun, Prasadam, Indira, Crawford, Ross, Xiao, Yin and Oloyede, Adekunle (2013). Near infrared (NIR) absorption spectra correlates with subchondral bone micro-CT parameters in osteoarthritic rat models. Bone, 53 (2), 350-357. doi: 10.1016/j.bone.2012.12.042

Application of near infrared (NIR) spectroscopy for determining the thickness of articular cartilage

Afara, I., Singh, S. and Oloyede, A. (2013). Application of near infrared (NIR) spectroscopy for determining the thickness of articular cartilage. Medical Engineering and Physics, 35 (1), 88-95. doi: 10.1016/j.medengphy.2012.04.003

Can proteoglycan change in articular cartilage be detected by ultrasound evaluation?

Afara, I., Wallace, S., Singh, S. and Oloyede, A. (2012). Can proteoglycan change in articular cartilage be detected by ultrasound evaluation?. RILEM Bookseries, 6, 393-398. doi: 10.1007/978-94-007-0723-8_57

Near infrared for non-destructive testing of articular cartilage

Afara, I., Sahama, T. and Oloyede, A. (2012). Near infrared for non-destructive testing of articular cartilage. RILEM Bookseries, 6, 399-404. doi: 10.1007/978-94-007-0723-8_58

The role of lamellate phospholipid bilayers in lubrication of joints

Pawlak, Zenon, Urbaniak, W., Gadomski, Adam, Yusuf, Kehinde Q., Afara, Isaac O. and Oloyede, Adekunle (2012). The role of lamellate phospholipid bilayers in lubrication of joints. Acta of Bioengineering and Biomechanics, 14 (4), 101-106. doi: 10.5277/abb120411

Non-destructive evaluation of articular cartilage defects using near-infrared (NIR) spectroscopy in osteoarthritic rat models and its direct relation to Mankin score

Afara, I., Prasadam, I., Crawford, R., Xiao, Y. and Oloyede, A. (2012). Non-destructive evaluation of articular cartilage defects using near-infrared (NIR) spectroscopy in osteoarthritic rat models and its direct relation to Mankin score. Osteoarthritis and Cartilage, 20 (11), 1367-1373. doi: 10.1016/j.joca.2012.07.007

Artificial neural network analysis of blood oxygen saturation signal enables accurate automatic screening of sleep apnea

Nikkonen, S., Afara, I., Myllymaa, S., Toyras, J. and Leppanen, T. (2019). Artificial neural network analysis of blood oxygen saturation signal enables accurate automatic screening of sleep apnea. World Sleep Congress, Vancouver, Canada, 20-25 September 2019. Amsterdam, Netherlands: Elsevier . doi: 10.1016/j.sleep.2019.11.624

Deep learning enables accurate sleep staging based on a single frontal EEG channel

Korkalainen, H., Aakko, J., Nikkonen, S., Kainulainen, S., Leino, A., Duce, B., Afara, I. O., Myllymaa, S., Toyras, J. and Leppanen, T. (2019). Deep learning enables accurate sleep staging based on a single frontal EEG channel. 15th World Sleep Congress, World Sleep 2019, Vancouver, Canada, 20-25 September, 2019 . Amsterdam, Netherlands: Elsevier BV.

Differentiating Sleepy and non-sleepy obstructive sleep apnea patients using nocturnal pulse oximetry and deep learning

Kainulainen, S., Toyras, J., Oksenberg, A., Korkalainen, H., Afara, I., Leino, A., Kalevo, L., Nikkonen, S., Gadoth, N., Kulkas, A., Myllymaa, S. and Leppanen, T. (2019). Differentiating Sleepy and non-sleepy obstructive sleep apnea patients using nocturnal pulse oximetry and deep learning. World Sleep Congress, Vancouver, Canada, 20-25 September 2019. Amsterdam, Netherlands: Elsevier . doi: 10.1016/j.sleep.2019.11.508

Arthroscopic near-infrared spectroscopic prediction of human meniscus properties

Ala-Myllymäki, Juho, Paakkonen, Tommi, Töyräsa, Juha and Afara, Isaac O. (2019). Arthroscopic near-infrared spectroscopic prediction of human meniscus properties. Bio-Optics: Design and Application 2019, Tucson, AZ, United States, 14–17 April 2019. Washington, D.C.: Optical Society of America (OSA). doi: 10.1364/BODA.2019.JT4A.35

Detection of enzymatically and mechanically induced degradation of bovine articular cartilage tissue with mid-infrared spectroscopy

Virtanen, V. K., Nippolainen, E., Shaikh, R., Afara, I., Toyras, J., Saarakkala, S. and Rieppo, L. (2019). Detection of enzymatically and mechanically induced degradation of bovine articular cartilage tissue with mid-infrared spectroscopy. OARSI World Congress on Osteoarthritis - Promoting Clinical and Basic Research in Osteoarthritis, Toronto, Canada, 2-5 May 2019. Oxford, United Kingdom: Elsevier . doi: 10.1016/j.joca.2019.02.035

Multi-spectral fiber spectroscopy methods as solutions for label-free medical diagnostics

Bibikova, Olga, Nippolainen, Ervin, Afara, Isaac, Haas, Julian, Virtanen, Vesa, Rieppo, Lasi, Adomaviciute, Sonata, Brommer, Harold, van Weeren, René, Melenteva, Anastasija, Belikova, Valeria, Zabarylo, Urszula, Minet, Olaf, Töyräs, Juha, Sablinskas, Valdas, Mizaikoff, Boris and Artyushenko, Viacheslav (2019). Multi-spectral fiber spectroscopy methods as solutions for label-free medical diagnostics. SPIE BiOS, 2019, San Francisco, CA, United States, 4 March 2019. Bellingham, WA, United States: SPIE. doi: 10.1117/12.2509174

Automated preprocessing of near infrared spectroscopic data

Torniainen, Jari, Afara, Isaac O., Prakash, Mithilesh, Sarin, Jaakko K., Stenroth, Lauri and Töyräs, Juha (2019). Automated preprocessing of near infrared spectroscopic data. Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP), Tucson, AZ, United States, 14-17 April 2019. Washington, DC, United States: Optical Society of America. doi: 10.1364/BODA.2019.DS2A.6

Mid-infrared and near infrared spectroscopic analysis of mechanically and enzymatically damaged cartilage

Nippolainen, Ervin, Shaikh, Rubina, Virtanen, Vesa, Rieppo, Lassi, Afara, Isaac, Saarakkala, Simo and Töyräs, Juha (2019). Mid-infrared and near infrared spectroscopic analysis of mechanically and enzymatically damaged cartilage. Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP), Tucson, AZ USA, 14-17 April 2019. Washington, DC USA: Optical Society of America. doi: 10.1364/BODA.2019.JT4A.37

Mid-infrared spectroscopic assessment of cartilage degeneration

Shaikh, Rubina, Nippolainen, Ervin, Virtanen, Vesa, Rieppo, Lassi, Haas, Julian, Mizaikoff, Boris, Artyushenko, Viacheslav, Bibikova, Olga, Afara, Isaac, Saarakkala, Simo and Töyräs, Juha (2019). Mid-infrared spectroscopic assessment of cartilage degeneration. Biophotonics Congress, Tucson, AZ, United States, 14–17 April 2019. Washington, D.C.: Optical Society of America (OSA). doi: 10.1364/BODA.2019.DS1A.3

Deep learning classification of cartilage integrity using near infrared spectroscopy

Afara, Isaac O., Sarin, Jaakko K., Ojanen, Simo, Finnila, Mikko, Herzog, Walter, Saarakkala, Simo, Korhonen, Rami K. and To¨yräs, Juha (2018). Deep learning classification of cartilage integrity using near infrared spectroscopy. Clinical and Translational Biophotonics, TRANSLATIONAL 2018, Hollywood, FL United States, 3-6 April 2018. Washington, DC United States: The Optical Society. doi: 10.1364/TRANSLATIONAL.2018.JTu3A.27

Near-infrared spectroscopy based arthroscopic evaluation of human knee joint cartilage, through automated selection of an anatomically specific regression model

Prakash, Mithilesh, Joukainen, Antti, Sarin, Jaakko, Rieppo, Lassi, Afara, Isaac and Töyräs, Juha (2018). Near-infrared spectroscopy based arthroscopic evaluation of human knee joint cartilage, through automated selection of an anatomically specific regression model. Optical Tomography and Spectroscopy (OTS 2018), Hollywood, FL, United States, 3-6 April 2018. Washington, D.C.: OSA - The Optical Society. doi: 10.1364/OTS.2018.OF4D.3

Near-infrared spectroscopy: A potential tool for mapping meniscus properties

Ala-Myllymäki, Juho, To¨yräs, Juha and Afara, Isaac O. (2018). Near-infrared spectroscopy: A potential tool for mapping meniscus properties. Clinical and Translational Biophotonics, TRANSLATIONAL 2018, Hollywood, FL United States, 3-6 April 2018. Washington, DC United States: The Optical Society. doi: 10.1364/TRANSLATIONAL.2018.JW3A.38

Spectroscopic evaluation of post-traumatic osteoarthritis in Shetland ponies

Sarin, Jaakko K., te Moller, Nikae, Brommer, Harold, van Weeren, Rene´, Mancini, Irina, Malda, Jos, Afara, Isaac O. and Töyräs, Juha (2018). Spectroscopic evaluation of post-traumatic osteoarthritis in Shetland ponies. Optical Tomography and Spectroscopy (OTS 2018), Hollywood, FL, United States, 3-6 April 2018. Washington, D.C.: OSA - The Optical Society. doi: 10.1364/OTS.2018.OTu4D.5

Lamellar-roller-bearing lubrication model on the cartilage surface

Pawlak, Z., Urbaniak, W., Yusuf, K. Q., Afara, I. O. and Oloyede, A. (2013). Lamellar-roller-bearing lubrication model on the cartilage surface. Politecnico di Torino (DIMEAS).