The University of Queensland

Alterations in mitochondrial glucose carbon metabolism in epilepsy and targeted metabolic treatments

Han, Felicity Y., McDonald, Tanya, Xu, Weizhi and Borges, Karin (2021). Alterations in mitochondrial glucose carbon metabolism in epilepsy and targeted metabolic treatments. Clinical bioenergetics: from pathophysiology to clinical translation. (pp. 653-677) edited by Sergej Ostojic. London, United Kingdom: Elsevier. doi: 10.1016/b978-0-12-819621-2.00029-2

Metabolic dysfunctions in epilepsy and novel metabolic treatment approaches

Tan, Kah Ni, McDonald, Tanya S. and Borges, Karin (2015). Metabolic dysfunctions in epilepsy and novel metabolic treatment approaches. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease: Prevention and Therapy. (pp. 461-470) edited by Ronald R Watson and Victor R Preedy. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/B978-0-12-411462-3.00048-5

Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders

McDonald, Tanya S., Lerskiatiphanich, Titaya, Woodruff, Trent M., McCombe, Pamela A. and Lee, John D. (2022). Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders. Journal of Cerebral Blood Flow and Metabolism, 43 (1), 26-43. doi: 10.1177/0271678x221135061

Fructose 1,6-bisphosphate is anticonvulsant and improves oxidative glucose metabolism within the hippocampus and liver in the chronic pilocarpine mouse epilepsy model

McDonald, Tanya S., Neal, Elliott S. and Borges, Karin (2021). Fructose 1,6-bisphosphate is anticonvulsant and improves oxidative glucose metabolism within the hippocampus and liver in the chronic pilocarpine mouse epilepsy model. Epilepsy and Behavior, 122 108223, 1-9. doi: 10.1016/j.yebeh.2021.108223

Glucose clearance and uptake is increased in the SOD1 G93A mouse model of amyotrophic lateral sclerosis through an insulin‐independent mechanism

McDonald, Tanya S., Kumar, Vinod, Fung, Jenny N., Woodruff, Trent M. and Lee, John D. (2021). Glucose clearance and uptake is increased in the SOD1 G93A mouse model of amyotrophic lateral sclerosis through an insulin‐independent mechanism. The FASEB Journal, 35 (7) e21707, e21707. doi: 10.1096/fj.202002450r

Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1 Mouse Model of Amyotrophic Lateral Sclerosis

Lee, John D., McDonald, Tanya S., Fung, Jenny N. T. and Woodruff, Trent M. (2020). Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1 Mouse Model of Amyotrophic Lateral Sclerosis. Molecular Neurobiology, 57 (10), 4143-4155. doi: 10.1007/s12035-020-02019-9

The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis

McDonald, Tanya S., McCombe, Pamela A., Woodruff, Trent M. and Lee, John D. (2020). The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis. The FASEB Journal, 34 (6) fj.201901781, 7225-7233. doi: 10.1096/fj.201901781

Triheptanoin alters [U- 13 C 6 ]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse model

McDonald, Tanya, Hodson, Mark P., Bederman, Ilya, Puchowicz, Michelle and Borges, Karin (2019). Triheptanoin alters [U- 13 C 6 ]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse model. Journal of Cerebral Blood Flow and Metabolism, 40 (3), 271678X19837380-691. doi: 10.1177/0271678X19837380

The effect of dichloroacetate in mouse models of epilepsy

Durie, Dylan, McDonald, Tanya S. and Borges, Karin (2018). The effect of dichloroacetate in mouse models of epilepsy. Epilepsy Research, 145, 77-81. doi: 10.1016/j.eplepsyres.2018.06.004

Impairments in oxidative glucose metabolism in epilepsy and metabolic treatments thereof

McDonald, Tanya, Puchowicz, Michelle and Borges, Karin (2018). Impairments in oxidative glucose metabolism in epilepsy and metabolic treatments thereof. Frontiers in Cellular Neuroscience, 12 274, 274. doi: 10.3389/fncel.2018.00274

Correction: Alterations in Cytosolic and Mitochondrial [U-13C]Glucose Metabolism in a Chronic Epilepsy Mouse Model (vol 4, e0341-16.2017, 2017)

McDonald, Tanya S., Carrasco-Pozo, Catalina, Hodson, Mark P. and Borges, Karin (2018). Correction: Alterations in Cytosolic and Mitochondrial [U-13C]Glucose Metabolism in a Chronic Epilepsy Mouse Model (vol 4, e0341-16.2017, 2017). eNeuro, 5 (2). doi: 10.1523/ENEURO.0154-18.2018

Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase

McDonald, Tanya S. and Borges, Karin (2017). Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase. Epilepsia, 58 (7), 1172-1180. doi: 10.1111/epi.13796

Alterations in cytosolic and mitochondrial [U-13C] glucose metabolism in a chronic epilepsy mouse model

McDonald, Tanya S., Carrasco-Pozo, Catalina, Hodson, Mark P. and Borges, Karin (2017). Alterations in cytosolic and mitochondrial [U-13C] glucose metabolism in a chronic epilepsy mouse model. eNeuro, 4 (1) e0341-16.2017, ENEURO.0341-16.2017. doi: 10.1523/ENEURO.0341-16.2017

Alternative fuels in epilepsy and amyotrophic lateral sclerosis

Tefera, Tesfaye W. , Tan, Kah Ni, McDonald, Tanya S.  and Borges, Karin (2016). Alternative fuels in epilepsy and amyotrophic lateral sclerosis. Neurochemical Research, 42 (6), 1-11. doi: 10.1007/s11064-016-2106-7

Triheptanoin protects motor neurons and delays the onset of motor symptoms in a mouse model of amyotrophic lateral sclerosis

Tefera, Tesfaye W., Wong, Yide, Barkl-Luke, Mallory E., Ngo, Shyuan T., Thomas, Nicola K., McDonald, Tanya S. and Borges, Karin (2016). Triheptanoin protects motor neurons and delays the onset of motor symptoms in a mouse model of amyotrophic lateral sclerosis. Plos One, 11 (8) e0161816, e0161816. doi: 10.1371/journal.pone.0161816

Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function

Tan, Kah Ni, Carrasco-Pozo, Catalina, McDonald, Tanya S., Puchowicz, Michelle and Borges, Karin (2016). Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function. Journal Of Cerebral Blood Flow and Metabolism, 37 (6), 2035-2048. doi: 10.1177/0271678X16659498

Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-l-Carnitine

Hadera, Mussie Ghezu, McDonald, Tanya, Smeland, Olav B., Meisingset, Tore W., Eloqayli, Haytham, Jaradat, Saied, Borges, Karin and Sonnewald, Ursula (2015). Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-l-Carnitine. Neurochemical Research, 41 (1-2), 86-95. doi: 10.1007/s11064-015-1728-5

Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epileps

Hadera, Mussie G., Smeland, Olav B., McDonald, Tanya S., Tan, Kah Ni, Sonnewald, Ursula and Borges, Karin (2014). Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epileps. Journal of Neurochemistry, 129 (1), 107-119. doi: 10.1111/jnc.12610

Alterations of hippocampal glucose metabolism by even versus uneven medium chain triglycerides

McDonald, Tanya S., Tan, Kah Ni, Hodson, Mark P. and Borges, Karin (2014). Alterations of hippocampal glucose metabolism by even versus uneven medium chain triglycerides. Journal Of Cerebral Blood Flow and Metabolism, 34 (1), 153-160. doi: 10.1038/jcbfm.2013.184

Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice

Smeland, Olav B., Hadera, Mussie G., McDonald, Tanya S., Sonnewald, Ursula and Borges, Karin (2013). Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice. Journal of Cerebral Blood Flow and Metabolism, 33 (7), 1090-1097. doi: 10.1038/jcbfm.2013.54

Triheptanoin alters anaplerosis and glutamate production in the chronic pilocarpine model of epilepsy

McDonald, Tanya, Hodson, Mark and Borges, Karin (2014). Triheptanoin alters anaplerosis and glutamate production in the chronic pilocarpine model of epilepsy. EB2014: Experimental Biology 2014, San Diago, CA United States, 26-30 April, 2014. Bethesda, MD United States: Federation of American Societies for Experimental Biology.

Mitochondrial metabolic dysfunction and glutamate reduction in the pilocarpine model of temporal lobe epilepsy in mice

Smeland, O. B., Hadera, M. G., McDonald, T., Sonnewald, U. and Borges, K. (2013). Mitochondrial metabolic dysfunction and glutamate reduction in the pilocarpine model of temporal lobe epilepsy in mice. 24th Biennial Meeting of the International Society for Neurochemistry and the American Society for Neurochemistry, Cancun Mexico, 20-24 Apr 2013. United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.12186

Energy metabolism in epilepsy: biochemical changes in glucose metabolism and the effects of metabolic treatments in murine seizure models

McDonald, Tanya (2018). Energy metabolism in epilepsy: biochemical changes in glucose metabolism and the effects of metabolic treatments in murine seizure models. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/uql.2018.629