Overview
Dr Moniruzzaman is working as a Senior Postdoctoral Research Fellow at the UQ Faculty of Medicine and PA Hospital of Metro South Health. His research focuses on the molecular pathobiology of inflammatory diseases, in particular, how mucosal epithelial cells and gut microbiota regulate immune function in the gastrointestinal (GI) tract and contribute to different diseases, including inflammatory bowel diseases (IBD) and functional GI symptoms called disorders of gut-brain interactions (DGBI). Dr Moniruzzaman received his PhD from The University of Queensland in 2020, where he studied how the interleukin(IL)-20 family of cytokines (IL-20, IL-22, and IL-24) regulate mucosal epithelial and immune function in inflammatory and infectious diseases, including ulcerative colitis (UC) and respiratory syncytial virus. After graduation, he received postdoctoral training in the IBD Lab at Mater Research Institute – UQ and Nanomedicine Lab at UQ School of Pharmacy, where he investigated the role of cannabinoid receptors in UC and colitis-associated colorectal cancer, development of cannabinoid formulations to treat UC, and involvement of autophagy gene Atg7 in 6-Thioguanin mediated protection from UC. He was awarded a highly competitive UQ Postdoctoral Research Fellowship (2021-2022) and UQ School of Pharmacy Strategic Grant (2022) to study cannabinoids and Atg7 in UC, and Translational Research Institute LINC Grant (2023) to study cannabinoids in palliative care of patients with advanced cancer. Currently, he is working on how intestinal microbial dysbiosis controls mucosal immune microenvironment and contributes to the pathogenesis of DGBI, including irritable bowel syndrome (IBS) and functional dyspepsia (FD).
“I started a career in biomedical research because of my deep curiosity about the way in which the human body works. Now, I am working to understand the contribution of different cytokines in human pathology, which will allow me to devise the causes behind the origin of inflammatory diseases and develop effective therapies to serve the community.”
Qualifications
- Doctor of Philosophy, The University of Queensland, Australia
- Master of Pharmacy, Dongguk University, South Korea
- Bachelor of Pharmacy (Hons), Stamford University Bangladesh
Research Interests
-
Immune regulation in mucosal inflammation
Mucosal inflammation is a complex process that occurs in various tissues, including the respiratory, gastrointestinal, and genitourinary tracts. It plays a crucial role in host defence against pathogens but can also contribute to the development of chronic inflammatory diseases including inflammatory bowel diseases (IBD). Immune regulation is essential to maintain a balance between protective immune responses and tissue homeostasis. In mucosal inflammation, the immune system employs a range of mechanisms to regulate the inflammatory process. One key aspect is the presence of specialized immune cells, such as regulatory T cells (Tregs), which help suppress excessive inflammation. Tregs modulate immune responses by releasing anti-inflammatory molecules and inhibiting the activation of other immune cells. Furthermore, mucosal tissues have unique immunological characteristics that contribute to immune regulation. For instance, the presence of secretory IgA antibodies helps prevent pathogens from invading epithelial cells and triggering an inflammatory response. Additionally, epithelial cells in mucosal tissues produce various antimicrobial peptides and cytokines that contribute to immune regulation and barrier integrity. The gut microbiota also plays a critical role in mucosal immune regulation. The microbiota interacts with the immune system and helps shape its development and function. Dysbiosis, an imbalance in the gut microbial composition, can lead to impaired immune regulation and contribute to mucosal inflammation. Understanding the mechanisms of immune regulation in mucosal inflammation is crucial for developing therapeutic interventions. Targeting Tregs, modulating the microbiota, and promoting barrier integrity are potential strategies for restoring immune balance and alleviating mucosal inflammation-related diseases. -
Epithelial function in mucosal inflammatory diseases
Mucosal epithelial cells line the mucosal surfaces, play a crucial role in the inflammatory diseases including inflammatory bowel diseases (IBD) and asthma. Epithelial cells form a physical barrier that separates the internal environment from the external milieu and participate in immune responses and tissue repair. Understanding epithelial function in mucosal inflammatory diseases is key to unravelling the underlying mechanisms and developing effective treatments. In mucosal inflammatory diseases, epithelial cells undergo significant alterations in their function. These changes include impaired barrier function, increased production of inflammatory mediators, and altered interactions with immune cells. The disruption of epithelial barrier integrity allows the entry of pathogens, allergens, and toxins, triggering inflammatory responses. Epithelial cells also actively participate in immune responses by sensing and responding to microbial and inflammatory signals. Upon activation, epithelial cells release cytokines, chemokines, and antimicrobial peptides, contributing to the recruitment and activation of immune cells. Moreover, dysregulation of epithelial cell function can lead to chronic inflammation and tissue damage. Inflammatory bowel diseases and asthma are most common examples of mucosal inflammatory diseases characterized by dysfunctional epithelial cells. A comprehensive understanding of epithelial function in mucosal inflammatory diseases may lead to the development of targeted therapies. Strategies to restore epithelial barrier integrity, modulate immune responses, and promote tissue repair could potentially alleviate symptoms and improve patient outcomes. -
Intestinal microbial dysbiosis in Disorders of Gut-Brain Interaction (DGBI)
Gut-brain interactions refer to the bidirectional communication and connection between the gut (digestive system) and the brain (central nervous system). The gut-brain axis is a complex network involving various pathways and signalling mechanisms that facilitate communication between these two systems. The enteric nervous system, also known as the "second brain," is a network of neurons within the gut that can function independently and communicate with the central nervous system. The vagus nerve, a major nerve connecting the gut and the brain, plays a crucial role in transmitting signals and information between these two systems. Gut-brain interactions are involved in regulating a wide range of functions, including digestion, appetite, mood, stress response, and immune function. The gut microbiota, the collection of microorganisms residing in the gut, also influences gut-brain interactions through the production of neurotransmitters and other signalling molecules. However, any disturbance in communication could lead to a variety of symptoms and conditions, called disorders of gut-brain interaction (DGBI) which includes motility disturbance, visceral hypersensitivity, altered mucosal and immune function, altered gut microbiota, and altered CNS processing. Therefore, understanding and studying gut-brain interactions is essential for gaining insights into various disorders and developing potential treatments. This project will span our understanding on the involvement of small intestinal microbial dysbiosis in the pathogenesis of DGBI, whether antimicrobial therapy is effective in all subtypes or if specific subgroups of patients would benefit more, and the bidirectional interactions between mucosal immune function and small intestinal microenvironment; and develop new therapeutics targeting gut microbiota.
Qualifications
- Master of Pharmacy, Dongguk University
- Bachelor of Pharmacy(Honours), Stamford University
- Doctor of Cell Biology, The University of Queensland
Publications
-
Journal Article: Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells
Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C. -H., Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Z. (2023). Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells. The Journal of Experimental Medicine, 220 (11) e20230106. doi: 10.1084/jem.20230106
-
Conference Publication: Enhancing the efficacy of cannabidiol using protein nanoparticles to treat inflammatory bowel disease
Moniruzzaman, M., Rewatkar, P., Begun, J. and Popat, A. (2023). Enhancing the efficacy of cannabidiol using protein nanoparticles to treat inflammatory bowel disease. 18th Congress of ECCO, Copenhagen, Denmark, 1-4 March 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjac190.0167
-
Moniruzzaman, Md., Wong, Kuan Yau, Wang, Ran, Symon, Hamish, Mueller, Alexandra, Rahman, M. Arifur and Hasnain, Sumaira Z. (2022). IL-20 activates ERK1/2 and suppresses splicing of X-box protein-1 in intestinal epithelial cells but does not improve pathology in acute or chronic models of colitis. International Journal of Molecular Sciences, 24 (1) 174, 174. doi: 10.3390/ijms24010174
-
Journal Article: A novel role for Interleukin-22 in suppressing major histocompatibility complex II in mucosal epithelial cells
Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C-H, Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Martin, Megan L., Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Zia (2022). A novel role for Interleukin-22 in suppressing major histocompatibility complex II in mucosal epithelial cells. SSRN Electronic Journal. doi: 10.2139/ssrn.4185134
-
Journal Article: Gut microbiota shape the inflammatory response in mice with an epithelial defect
Wang, Ran, Moniruzzaman, Md, Wong, Kuan Yau, Wiid, Percival, Harding, Alexa, Giri, Rabina, Tong, Wendy Hui, Creagh, Jackie, Begun, Jakob, McGuckin, Michael A. and Hasnain, Sumaira Z. (2021). Gut microbiota shape the inflammatory response in mice with an epithelial defect. Gut microbes, 13 (1), 1-18. doi: 10.1080/19490976.2021.1887720
-
Ferdous, Afia, Janta, Rabir Ahmed, Arpa, Rubaiya Nushin, Afroze, Mirola, Khan, Mala and Moniruzzaman, Md. (2020). The leaves of Bougainvillea spectabilis suppressed inflammation and nociception in vivo through the modulation of glutamatergic, cGMP, and ATP-sensitive K+ channel pathways. Journal of Ethnopharmacology, 261 113148, 113148. doi: 10.1016/j.jep.2020.113148
-
Journal Article: Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway
Moniruzzaman, Md., Wang, Ran, Jeet, Varinder, McGuckin, Michael A. and Hasnain, Sumaira Z. (2019). Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway. International Journal of Molecular Sciences, 20 (14) 3468, 3468. doi: 10.3390/ijms20143468
-
Journal Article: The ethyl acetate fraction from Physalis alkekengi inhibits LPS-induced pro-inflammatory mediators in BV2 cells and inflammatory pain in mice
Moniruzzaman, Md., Bose, Shambhunath, Kim, Young-Mi, Chin, Young-Won and Cho, Jungsook (2016). The ethyl acetate fraction from Physalis alkekengi inhibits LPS-induced pro-inflammatory mediators in BV2 cells and inflammatory pain in mice. Journal of Ethnopharmacology, 181, 26-36. doi: 10.1016/j.jep.2016.01.023
Supervision
-
Designer Nanoparticles for Oral and Targeted Delivery of Protein Therapeutics
Doctor Philosophy
Publications
Featured Publications
-
Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells
Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C. -H., Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Z. (2023). Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells. The Journal of Experimental Medicine, 220 (11) e20230106. doi: 10.1084/jem.20230106
-
Moniruzzaman, M., Rewatkar, P., Begun, J. and Popat, A. (2023). Enhancing the efficacy of cannabidiol using protein nanoparticles to treat inflammatory bowel disease. 18th Congress of ECCO, Copenhagen, Denmark, 1-4 March 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjac190.0167
-
Moniruzzaman, Md., Wong, Kuan Yau, Wang, Ran, Symon, Hamish, Mueller, Alexandra, Rahman, M. Arifur and Hasnain, Sumaira Z. (2022). IL-20 activates ERK1/2 and suppresses splicing of X-box protein-1 in intestinal epithelial cells but does not improve pathology in acute or chronic models of colitis. International Journal of Molecular Sciences, 24 (1) 174, 174. doi: 10.3390/ijms24010174
-
Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C-H, Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Martin, Megan L., Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Zia (2022). A novel role for Interleukin-22 in suppressing major histocompatibility complex II in mucosal epithelial cells. SSRN Electronic Journal. doi: 10.2139/ssrn.4185134
-
Gut microbiota shape the inflammatory response in mice with an epithelial defect
Wang, Ran, Moniruzzaman, Md, Wong, Kuan Yau, Wiid, Percival, Harding, Alexa, Giri, Rabina, Tong, Wendy Hui, Creagh, Jackie, Begun, Jakob, McGuckin, Michael A. and Hasnain, Sumaira Z. (2021). Gut microbiota shape the inflammatory response in mice with an epithelial defect. Gut microbes, 13 (1), 1-18. doi: 10.1080/19490976.2021.1887720
-
Ferdous, Afia, Janta, Rabir Ahmed, Arpa, Rubaiya Nushin, Afroze, Mirola, Khan, Mala and Moniruzzaman, Md. (2020). The leaves of Bougainvillea spectabilis suppressed inflammation and nociception in vivo through the modulation of glutamatergic, cGMP, and ATP-sensitive K+ channel pathways. Journal of Ethnopharmacology, 261 113148, 113148. doi: 10.1016/j.jep.2020.113148
-
Moniruzzaman, Md., Wang, Ran, Jeet, Varinder, McGuckin, Michael A. and Hasnain, Sumaira Z. (2019). Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway. International Journal of Molecular Sciences, 20 (14) 3468, 3468. doi: 10.3390/ijms20143468
-
Moniruzzaman, Md., Bose, Shambhunath, Kim, Young-Mi, Chin, Young-Won and Cho, Jungsook (2016). The ethyl acetate fraction from Physalis alkekengi inhibits LPS-induced pro-inflammatory mediators in BV2 cells and inflammatory pain in mice. Journal of Ethnopharmacology, 181, 26-36. doi: 10.1016/j.jep.2016.01.023
Journal Article
-
Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells
Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C. -H., Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Z. (2023). Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells. The Journal of Experimental Medicine, 220 (11) e20230106. doi: 10.1084/jem.20230106
-
McGuckin, Michael A., Davies, Julie M., Felgner, Pascal, Wong, Kuan Yau, Giri, Rabina, He, Yaowu, Moniruzzaman, Md., Kryza, Thomas, Sajiir, Haressh, Hooper, John D., Florin, Timothy H., Begun, Jakob, Oussalah, Abderrahim, Hasnain, Sumaira Z., Hensel, Michael and Sheng, Yong H. (2023). MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier. Cellular and Molecular Gastroenterology and Hepatology. doi: 10.1016/j.jcmgh.2023.08.011
-
Ong, Kanyin Liane, Stafford, Lauryn K, McLaughlin, Susan A, Boyko, Edward J, Vollset, Stein Emil, Smith, Amanda E, Dalton, Bronte E, Duprey, Joe, Cruz, Jessica A, Hagins, Hailey, Lindstedt, Paulina A, Aali, Amirali, Abate, Yohannes Habtegiorgis, Abate, Melsew Dagne, Abbasian, Mohammadreza, Abbasi-Kangevari, Zeinab, Abbasi-Kangevari, Mohsen, Abd ElHafeez, Samar, Abd-Rabu, Rami, Abdulah, Deldar Morad, Abdullah, Abu Yousuf Md, Abedi, Vida, Abidi, Hassan, Aboagye, Richard Gyan, Abolhassani, Hassan, Abu-Gharbieh, Eman, Abu-Zaid, Ahmed, Adane, Tigist Demssew, Adane, Denberu Eshetie ... Vos, Theo (2023). Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet, 402 (10397), 203-234. doi: 10.1016/s0140-6736(23)01301-6
-
Virus-like silica nanoparticles enhance macromolecule permeation in vivo
Cao, Yuxue, Janjua, Taskeen Iqbal, Qu, Zhi, Draphoen, Bastian, Bai, Yunfan, Linden, Mika, Moniruzzaman, Md., Hasnain, Sumaira Z., Kumeria, Tushar and Popat, Amirali (2023). Virus-like silica nanoparticles enhance macromolecule permeation in vivo. Biomaterials Science, 11 (13), 4508-4521. doi: 10.1039/d3bm00137g
-
Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma
Janjua, Taskeen Iqbal, Cao, Yuxue, Ahmed-Cox, Aria, Raza, Aun, Moniruzzaman, Md, Akhter, Dewan Taslima, Fletcher, Nicholas L., Kavallaris, Maria, Thurecht, Kristofer J. and Popat, Amirali (2023). Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma. Journal of Controlled Release, 357, 161-174. doi: 10.1016/j.jconrel.2023.03.040
-
Momtazmanesh, Sara, Moghaddam, Sahar Saeedi, Ghamari, Seyyed-Hadi, Rad, Elaheh Malakan, Rezaei, Negar, Shobeiri, Parnian, Aali, Amirali, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abdelmasseh, Michael, Abdoun, Meriem, Abdulah, Deldar Morad, Md Abdullah, Abu Yousuf, Abedi, Aidin, Abolhassani, Hassan, Abrehdari-Tafreshi, Zahra, Achappa, Basavaprabhu, Adane Adane, Denberu Eshetie, Adane, Tigist Demssew, Addo, Isaac Yeboah, Adnan, Mohammad, Sakilah Adnani, Qorinah Estiningtyas, Ahmad, Sajjad, Ahmadi, Ali, Ahmadi, Keivan, Ahmed, Ali, Ahmed, Ayman, Rashid, Tarik Ahmed, Al Hamad, Hanadi ... Farzadfar, Farshad (2023). Global burden of chronic respiratory diseases and risk factors, 1990–2019: an update from the Global Burden of Disease Study 2019. eClinicalMedicine, 59 101936, 101936. doi: 10.1016/j.eclinm.2023.101936
-
Shin, Youn Ho, Hwang, Jimin, Kwon, Rosie, Lee, Seung Won, Kim, Min Seo, Shin, Youn Ho, Hwang, Jimin, Kwon, Rosie, Lee, Seung Won, Kim, Min Seo, Abate, Yohannes Habtegiorgis, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abdelmasseh, Michael, Abdulah, Deldar Morad, Aboagye, Richard Gyan, Abolhassani, Hassan, Abrams, Elissa M., Abtew, Yonas Derso, Abu-Gharbieh, Eman, Adane, Denberu Eshetie Adane, Adane, Tigist Demssew, Addo, Isaac Yeboah, Adha, Rishan, Adibi, Amin, Adnani, Qorinah Estiningtyas Sakilah, Agrawal, Anurag, Ahmad, Sohail, Ahmadi, Ali ... Yon, Dong Keon (2023). Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019. Allergy: European Journal of Allergy and Clinical Immunology, 78 (8), 2232-2254. doi: 10.1111/all.15807
-
Moniruzzaman, Md., Wong, Kuan Yau, Wang, Ran, Symon, Hamish, Mueller, Alexandra, Rahman, M. Arifur and Hasnain, Sumaira Z. (2022). IL-20 activates ERK1/2 and suppresses splicing of X-box protein-1 in intestinal epithelial cells but does not improve pathology in acute or chronic models of colitis. International Journal of Molecular Sciences, 24 (1) 174, 174. doi: 10.3390/ijms24010174
-
GBD 2019 LRI Collaborators and Moniruzzaman, Md (2022). Age-sex differences in the global burden of lower respiratory infections and risk factors, 1990-2019: results from the Global Burden of Disease Study 2019. The Lancet Infectious Diseases, 22 (11), 1626-1647. doi: 10.1016/S1473-3099(22)00510-2
-
GBD 2019 Dementia Forecasting Collaborators, Moniruzzaman, Md and Moni, Mohammad Ali (2022). Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. The Lancet. Public health, 7 (2), e105-e125. doi: 10.1016/S2468-2667(21)00249-8
-
Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C-H, Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Martin, Megan L., Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Zia (2022). A novel role for Interleukin-22 in suppressing major histocompatibility complex II in mucosal epithelial cells. SSRN Electronic Journal. doi: 10.2139/ssrn.4185134
-
Parekh, Khushali, Hariharan, Kartik, Qu, Zhi, Rewatkar, Prarthana, Cao, Yuxue, Moniruzzaman, Md., Pandey, Preeti, Popat, Amirali and Mehta, Tejal (2021). Tacrolimus encapsulated mesoporous silica nanoparticles embedded hydrogel for the treatment of atopic dermatitis. International Journal of Pharmaceutics, 608 121079, 121079. doi: 10.1016/j.ijpharm.2021.121079
-
Elshaer, Dana, Moniruzzaman, Md., Ong, Yi Theng, Qu, Zhi, Schreiber, Veronika, Begun, Jakob and Popat, Amirali (2021). Facile synthesis of dendrimer like mesoporous silica nanoparticles to enhance targeted delivery of interleukin-22. Biomaterials Science, 9 (22), 7402-7411. doi: 10.1039/d1bm01352a
-
Pujara, Naisarg, Giri, Rabina, Yau Wong, Kuan, Qu, Zhi, Rewatkar, Prarthana, Moniruzzaman, Md., Begun, Jakob, Ross, Benjamin P., McGuckin, Michael and Popat, Amirali (2021). pH – responsive colloidal carriers assembled from β-lactoglobulin and epsilon poly-l-lysine for oral drug delivery. Journal of Colloid and Interface Science, 589, 45-55. doi: 10.1016/j.jcis.2020.12.054
-
Gut microbiota shape the inflammatory response in mice with an epithelial defect
Wang, Ran, Moniruzzaman, Md, Wong, Kuan Yau, Wiid, Percival, Harding, Alexa, Giri, Rabina, Tong, Wendy Hui, Creagh, Jackie, Begun, Jakob, McGuckin, Michael A. and Hasnain, Sumaira Z. (2021). Gut microbiota shape the inflammatory response in mice with an epithelial defect. Gut microbes, 13 (1), 1-18. doi: 10.1080/19490976.2021.1887720
-
Ferdous, Afia, Janta, Rabir Ahmed, Arpa, Rubaiya Nushin, Afroze, Mirola, Khan, Mala and Moniruzzaman, Md. (2020). The leaves of Bougainvillea spectabilis suppressed inflammation and nociception in vivo through the modulation of glutamatergic, cGMP, and ATP-sensitive K+ channel pathways. Journal of Ethnopharmacology, 261 113148, 113148. doi: 10.1016/j.jep.2020.113148
-
Qu, Zhi, Wong, Kuan Yau, Moniruzzaman, Md., Begun, Jakob, Santos, Hélder A, Hasnain, Sumaira Z., Kumeria, Tushar, McGuckin, Michael A. and Popat, Amirali (2020). One‐pot synthesis of pH‐responsive eudragit‐mesoporous silica nanocomposites enable colonic delivery of glucocorticoids for the treatment of inflammatory bowel disease. Advanced Therapeutics, 4 (2) 2000165, 2000165. doi: 10.1002/adtp.202000165
-
Pujara, Naisarg, Wong, Kuan Yau, Qu, Zhi, Wang, Ran, Moniruzzaman, Md., Rewatkar, Prarthana, Kumeria, Tushar, Ross, Benjamin P., McGuckin, Michael and Popat, Amirali (2020). Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis. Molecular Pharmaceutics, 18 (2) acs.molpharmaceut.0c00048, 627-640. doi: 10.1021/acs.molpharmaceut.0c00048
-
Moniruzzaman, Md., Wang, Ran, Jeet, Varinder, McGuckin, Michael A. and Hasnain, Sumaira Z. (2019). Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway. International Journal of Molecular Sciences, 20 (14) 3468, 3468. doi: 10.3390/ijms20143468
-
Moniruzzaman, Md, Mannan, Md Abdul, Hossen Khan, Md Farhad, Abir, Ariful Basher and Afroze, Mirola (2018). The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system. BMC Complementary and Alternative Medicine, 18 (1) 283, 283. doi: 10.1186/s12906-018-2338-y
-
Moniruzzaman, M., Chin, Young-Won and Cho, Jungsook (2018). HO-1 dependent antioxidant effects of ethyl acetate fraction from Physalis alkekengi fruit ameliorates scopolamine-induced cognitive impairments. Cell Stress and Chaperones, 23 (4), 763-772. doi: 10.1007/s12192-018-0887-0
-
Immune regulation of the unfolded protein response at the mucosal barrier in viral infection
Wang, Ran, Moniruzzaman, Md., Shuffle, Eric, Lourie, Rohan and Hasnain, Sumaira Z. (2018). Immune regulation of the unfolded protein response at the mucosal barrier in viral infection. Clinical & Translational Immunology, 7 (4) e1014, e1014. doi: 10.1002/cti2.1014
-
Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn
Moniruzzaman, Md., Hossain, Md. Sarwar and Bhattacharjee, Partha Sharoti (2016). Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn. Journal of Ethnopharmacology, 186, 205-208. doi: 10.1016/j.jep.2016.04.008
-
Effect of CCL2 on BV2 microglial cell migration: involvement of probable signaling pathways
Bose, Shambhunath, Kim, Sunyoung, Oh, Yeonsoo, Moniruzzaman, Md., Lee, Gyeongjun and Cho, Jungsook (2016). Effect of CCL2 on BV2 microglial cell migration: involvement of probable signaling pathways. Cytokine, 81, 39-49. doi: 10.1016/j.cyto.2016.02.001
-
Moniruzzaman, Md., Bose, Shambhunath, Kim, Young-Mi, Chin, Young-Won and Cho, Jungsook (2016). The ethyl acetate fraction from Physalis alkekengi inhibits LPS-induced pro-inflammatory mediators in BV2 cells and inflammatory pain in mice. Journal of Ethnopharmacology, 181, 26-36. doi: 10.1016/j.jep.2016.01.023
-
Moniruzzaman, Md., Sharoti Bhattacharjee, Partha, Rahman Pretty, Moushumi and Sarwar Hossain, Md. (2016). Sedative and anxiolytic-like actions of ethanol extract of leaves of Glinus oppositifolius (Linn.) Aug. DC. Evidence-Based Complementary and Alternative Medicine, 2016 8541017. doi: 10.1155/2016/8541017
-
Sharmin Ani, Nushrat, Chakraborty, Sudip and Moniruzzaman, Md. (2016). The methanolic extract from Murraya koenigii L. inhibits glutamate-induced pain and involves ATP-sensitive K+ Channel as antinociceptive mechanism. Advances in Pharmacological Sciences, 2016 3790860, 1-6. doi: 10.1155/2016/3790860
-
Moniruzzaman, Md, Lee, Gyeongjun, Bose, Shambhunath, Choi, Minho, Jung, Jae-Kyung, Lee, Heesoon and Cho, Jungsook (2015). Antioxidant and anti-inflammatory activities of N-((3,4-Dihydro-2H-benzo[h]chromene-2-yl)methyl)-4-methoxyaniline in LPS-induced BV2 microglial cells. Biological & Pharmaceutical Bulletin, 38 (12), 1831-1835. doi: 10.1248/bpb.b15-00473
-
Evaluation of antinociceptive activity of ethanol extract of bark of Polyalthia longifolia
Moniruzzaman, Md., Ferdous, Afia and Bokul, Fatama Wahid (2015). Evaluation of antinociceptive activity of ethanol extract of bark of Polyalthia longifolia. Journal of Ethnopharmacology, 172, 364-367. doi: 10.1016/j.jep.2015.06.053
-
Moniruzzaman, Md, Ferdous, Afia and Irin, Shamima (2015). Evaluation of antinociceptive effect of ethanol extract of Hedyotis corymbosa Linn. whole plant in mice. Journal of Ethnopharmacology, 161, 82-85. doi: 10.1016/j.jep.2014.12.011
-
Evaluation of antinociceptive activity of ethanol extract of leaves of Adenanthera pavonina
Moniruzzaman, Md., Khatun, Ambia and Imam, Mohammad Zafar (2015). Evaluation of antinociceptive activity of ethanol extract of leaves of Adenanthera pavonina. Evidence-Based Complementary and Alternative Medicine, 2015 412497, 1-8. doi: 10.1155/2015/412497
-
Evaluation of sedative and hypnotic activity of ethanolic extract of Scoparia dulcis Linn
Moniruzzaman, Md., Rahman, Md. Atikur and Ferdous, Afia (2015). Evaluation of sedative and hypnotic activity of ethanolic extract of Scoparia dulcis Linn. Evidence-Based Complementary and Alternative Medicine, 2015 873954. doi: 10.1155/2015/873954
-
Evaluation of antinociceptive effect of methanolic extract of leaves of Crataeva nurvala Buch.-Ham.
Moniruzzaman, Md and Imam, Mohammad Zafar (2014). Evaluation of antinociceptive effect of methanolic extract of leaves of Crataeva nurvala Buch.-Ham.. BMC Complementary and Alternative Medicine, 14 (1) 354, 1-7. doi: 10.1186/1472-6882-14-354
-
Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica
Imam, Mohammad Zafar and Moniruzzaman, Md (2014). Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica. Journal of Ethnopharmacology, 154 (1), 109-115. doi: 10.1016/j.jep.2014.03.032
Conference Publication
-
Moniruzzaman, M., Rewatkar, P., Begun, J. and Popat, A. (2023). Enhancing the efficacy of cannabidiol using protein nanoparticles to treat inflammatory bowel disease. 18th Congress of ECCO, Copenhagen, Denmark, 1-4 March 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjac190.0167
-
An,Yoon-Kyo, Lindsay, Niamh, Allan, Natalie, Khoo, Emi, Amiss, Anna, Moniruzzaman, Md, Fernandes, Richard , Ooi, Soong-Yuan J., Thin, Lena W.Y., Mstj, Daniel Lightowler, Connor, Susan, Williams, Astrid-Jane, De Cruz, Peter, Suen, Christopher Li Wai, Kariyawasam, Viraj C., Mitrev, Nicola, Ghaly, Simon, Andrews, Jane M., Christensen, Britt, Sparrow, Miles, White, Lauren, Bryant, Robert, Ding, Nik S., Leong, Rupert W., Van Langenberg, Daniel R., Seltenreich, Hans, Subramaniam, Kavitha, Radford-Smith, Graham and Begun, Jakob (2022). Post-induction IL-12/23 levels correlate with clinical response and remission after ustekinumab in a multicenter prospective cohort study of patients with Crohn’s disease: Preliminary induction results of the AURORA study, including the Australia New Zealand IBD Consortium Cohort. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) 2022, Sydney, NSW Australia, 9–11 September 2022. Richmond, VIC Australia: John Wiley & Sons. doi: 10.1111/jgh.15953
-
Rahman, M. A., Moniruzzaman, M., Wang, R., Harding, A., Wiid, P., Sajiir, H., Yong, K. Y., Sheng, Y., Mueller, A., Symon, H., Varelias, A., McGuckin, M., Phipps, S. and Hasnain, S. (2022). A novel role for interleukin-22 signaling in modulating mucosal epithelial cell antigen presentation machinery to control disease. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW), Sydney, NSW, Australia, 9–11 September 2022. Richmond, VIC, Australia: John Wiley & Sons.
-
Wang, R., Moniruzzaman, M., Wang, K., Upham, J. W., McGuckin, M., Phipps, S. and Hasnain, S. Z. (2020). Blocking endogenous IL-22 is associated with reduced viral load and improved lung pathology in respiratory viral infections. International Conference of the American-Thoracic-Society (ATS), Online, 10 November 2020. New York, NY, United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6530
-
Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection
Hasnain, S., Wang, R., Taylor, S., Wong, K. Y., Moniruzzaman, M., Upham, J., Spann, K., Mcguckin, M. A., Burr, L. and Phipps, S. (2020). Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, VIC, Australia, 27–31 March 2020. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13777
-
Moniruzzaman, M., Wang, R., Wong, K., Tong, H., McGuckin, M. and Hasnain, S. (2019). Interleukin-20 subfamily cytokines in controlling intestinal inflammation and epithelial barrier integrity. Congress of ECCO, Copenhagen, Denmark, 6-9 March 2019. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjy222.044
-
Wang, R., Taylor, S., Moniruzzaman, M., Wong, K., Upham, J., Spann, K., McGuckin, M., Phipps, S. and Hasnain, S. (2019). A novel role of IL-22 in regulating epithelial MHC molecule expression and antigen presentation during viral infection. 17th International Congress of Immunology (IUIS), Beijing, People's Republic of China, 9-23 October 2019. Weinheim, Germany: Wiley.
-
Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation
Wang, R., Giri, R., Moniruzzaman, M., Tong, H., Wong, K. Y., Begun, J., McGuckin, M. A. and Hasnain, S. Z. (2018). Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “Gut Matters”, Brisbane, QLD, Australia, 8-10 September 2018. Richmond, VIC, Australia: John Wiley & Sons.
-
Interleukin-22: A potential therapy to control intestinal inflammation
Moniruzzaman, M., Wang, R., Wong, K. Y., Tong, H., McGuckin, M. A. and Hasnain, S. Z. (2018). Interleukin-22: A potential therapy to control intestinal inflammation. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “Gut Matters”, Brisbane, QLD, Australia, 8-10 September 2018. Richmond, VIC, Australia: John Wiley & Sons.
Other Outputs
-
Therapeutic manipulation of interleukin-20 subfamily of cytokines in ulcerative colitis
Moniruzzaman, Md (2020). Therapeutic manipulation of interleukin-20 subfamily of cytokines in ulcerative colitis. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/uql.2020.859
PhD and MPhil Supervision
Current Supervision
-
Designer Nanoparticles for Oral and Targeted Delivery of Protein Therapeutics
Doctor Philosophy — Associate Advisor
Other advisors:
