~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.
Journal Article: Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells
Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C. -H., Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Z. (2023). Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells. The Journal of Experimental Medicine, 220 (11) e20230106. doi: 10.1084/jem.20230106
Journal Article: MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier
McGuckin, Michael A., Davies, Julie M., Felgner, Pascal, Wong, Kuan Yau, Giri, Rabina, He, Yaowu, Moniruzzaman, Md., Kryza, Thomas, Sajiir, Haressh, Hooper, John D., Florin, Timothy H., Begun, Jakob, Oussalah, Abderrahim, Hasnain, Sumaira Z., Hensel, Michael and Sheng, Yong H. (2023). MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier. Cellular and Molecular Gastroenterology and Hepatology. doi: 10.1016/j.jcmgh.2023.08.011
Conference Publication: A novel role for interleukin-22 signaling in modulating mucosal epithelial cell antigen presentation machinery to control disease
Rahman, M. A., Moniruzzaman, M., Wang, R., Harding, A., Wiid, P., Sajiir, H., Yong, K. Y., Sheng, Y., Mueller, A., Symon, H., Varelias, A., McGuckin, M., Phipps, S. and Hasnain, S. (2022). A novel role for interleukin-22 signaling in modulating mucosal epithelial cell antigen presentation machinery to control disease. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW), Sydney, NSW, Australia, 9–11 September 2022. Richmond, VIC, Australia: John Wiley & Sons.
(2017–2020) United States Congressionally Directed Medical Research Programs - Peer Reviewed Medical Research Program
Pancreatic targeting of IL-22 therapy for diabetes
(2016–2018) NHMRC Development Grant
Elucidation of the Mechanism of IL-22-Mediated Suppression of Beta-Cell Stress in Diabetes
(2016–2017) NHMRC Project Grant
(2017) Doctor Philosophy
Characterisation of immunopathology in non-CF bronchiectasis
(2015) Doctor Philosophy
Targeting IL-23/TH17 Axis in Suppressing Intestinal Inflammation
(2015) Doctor Philosophy
Michael A. McGuckin and David J. Thornton eds. (2012). Mucins: methods and protocols. Methods in Molecular Biology, New York, NY, United States: Humana Press. doi: 10.1007/978-1-61779-513-8
McGuckin, Michael A., Thornton, David J. and Whitsett, Jeffrey A. (2015). Mucins and mucus. Mucosal immunology: fourth edition. (pp. 231-250) edited by Jiri Mestecky, Warren Strober, Michael W. Russell, Brian L. Kelsall, Hilde Cheroutre and Bart N. Lambrecht. Kidlington, Oxford, United Kingdom: Elsevier. doi: 10.1016/B978-0-12-415847-4.00014-8
Introduction to mucins in cancer
McGuckin, Michael A. (2013). Introduction to mucins in cancer. Mucins and Cancer. (pp. 6-18) edited by Joyce Taylor-Papadimitriou and Joy M Burchell. London: Future Medicine Limited. doi: 10.2217/fmeb2013.13.123
Secreted effectors of the innate mucosal barrier
McGuckin, M. A., Ouellette, A. J. and Wu, G. D. (2013). Secreted effectors of the innate mucosal barrier. Principles of mucosal immunology. (pp. 37-51) edited by Phillip D. Smith, ThomasT. MacDonald and Richard S. Blumberg. London, United Kingdom: Taylor & Francis.
Detecting, visualising, and quantifying mucins
Harrop, Ceri A., Thornton, David J. and McGuckin, Michael A. (2012). Detecting, visualising, and quantifying mucins. Mucins: Methods and Protocols. (pp. 49-66) edited by Michael A. McGuckin and David J. Thornton. New York, NY, United States: Humana Press. doi: 10.1007/978-1-61779-513-8_3
Eri, Rajaraman, McGuckin, Michael A. and Wadley, Robert (2012). T cell transfer model of colitis: a great tool to assess the contribution of T cells in chronic intestinal inflammation. Leucocytes: methods and protocols. (pp. 261-275) New York, United States: Humana Press. doi: 10.1007/978-1-61779-527-5_19
Techniques for assessment of interactions of mucins with microbes and parasites in vitro and in vivo
Sheng, Yong H., Hasnain, Sumaira Z, Png, Chin Wen, McGuckin, Michael A. and Lindén, Sara K. (2012). Techniques for assessment of interactions of mucins with microbes and parasites in vitro and in vivo. Mucins: Methods and Protocols. (pp. 297-312) edited by Michael A. McGuckin and David J. Thornton. New York, NY, United States: Humana Press. doi: 10.1007/978-1-61779-513-8_18
Linden, Sara K. and McGuckin, Michael A. (2010). Microbes at the host surface. Current research, technology and education topics in applied microbiology and microbial biotechnology. (pp. 591-596) edited by A. Mendez-Vilas. Badajoz, Spain: Formatex Research Center.
Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells
Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C. -H., Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Z. (2023). Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells. The Journal of Experimental Medicine, 220 (11) e20230106. doi: 10.1084/jem.20230106
McGuckin, Michael A., Davies, Julie M., Felgner, Pascal, Wong, Kuan Yau, Giri, Rabina, He, Yaowu, Moniruzzaman, Md., Kryza, Thomas, Sajiir, Haressh, Hooper, John D., Florin, Timothy H., Begun, Jakob, Oussalah, Abderrahim, Hasnain, Sumaira Z., Hensel, Michael and Sheng, Yong H. (2023). MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier. Cellular and Molecular Gastroenterology and Hepatology. doi: 10.1016/j.jcmgh.2023.08.011
Sheng, Yong H., Davies, Julie M., Wang, Ran, Wong, Kuan Yau, Giri, Rabina, Yang, Yuanhao, Begun, Jakob, Florin, Timothy H., Hasnain, Sumaira Z. and McGuckin, Michael A. (2022). MUC1 mediated macrophage activation promotes colitis-associated colorectal cancer via activating the IL-6/STAT3 axis. Cellular and Molecular Gastroenterology and Hepatology, 14 (4), 789-811. doi: 10.1016/j.jcmgh.2022.06.010
Secreted NF-κB suppressive microbial metabolites modulate gut inflammation
Giri, Rabina, Hoedt, Emily C., Khushi, Shamsunnahar, Salim, Angela A., Bergot, Anne-Sophie, Schreiber, Veronika, Thomas, Ranjeny, McGuckin, Michael A., Florin, Timothy H., Morrison, Mark, Capon, Robert J., Ó Cuív, Páraic and Begun, Jakob (2022). Secreted NF-κB suppressive microbial metabolites modulate gut inflammation. Cell Reports, 39 (2) 110646, 110646. doi: 10.1016/j.celrep.2022.110646
Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers
Begley, C. Glenn, Ashton, Mark, Baell, Jonathan, Bettess, Michael, Brown, Michael P., Carter, Brett, Charman, William N., Davis, Christopher, Fisher, Simon, Frazer, Ian, Gautam, Anand, Jennings, Michael P., Kearney, Philip, Keeffe, Eloise, Kelly, Darren, Lopez, Angel F., McGuckin, Michael, Parker, Michael W., Rayner, Craig, Roberts, Brett, Rush, James S. and Sullivan, Mark (2021). Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers. Science Translational Medicine, 13 (612) eabd5524, eabd5524. doi: 10.1126/scitranslmed.abd5524
Pujara, Naisarg, Giri, Rabina, Yau Wong, Kuan, Qu, Zhi, Rewatkar, Prarthana, Moniruzzaman, Md., Begun, Jakob, Ross, Benjamin P., McGuckin, Michael and Popat, Amirali (2021). pH – responsive colloidal carriers assembled from β-lactoglobulin and epsilon poly-l-lysine for oral drug delivery. Journal of Colloid and Interface Science, 589, 45-55. doi: 10.1016/j.jcis.2020.12.054
Sheng, Yong Hua, Giri, Rabina, Davies, Julie, Schreiber, Veronika, Alabbas, Saleh, Movva, Ramya, He, Yaowu, Wu, Andy, Hooper, John, McWhinney, Brett, Oancea, Iulia, Kijanka, Gregor, Hasnain, Sumaira, Lucke, Andrew J., Fairlie, David P., McGuckin, Michael A., Florin, Timothy H. and Begun, Jakob (2021). A nucleotide analog prevents colitis associated cancer via Β-catenin independently of inflammation and autophagy. Cellular and Molecular Gastroenterology and Hepatology, 11 (1), 33-53. doi: 10.1016/j.jcmgh.2020.05.012
Gut microbiota shape the inflammatory response in mice with an epithelial defect
Wang, Ran, Moniruzzaman, Md, Wong, Kuan Yau, Wiid, Percival, Harding, Alexa, Giri, Rabina, Tong, Wendy Hui, Creagh, Jackie, Begun, Jakob, McGuckin, Michael A. and Hasnain, Sumaira Z. (2021). Gut microbiota shape the inflammatory response in mice with an epithelial defect. Gut microbes, 13 (1), 1-18. doi: 10.1080/19490976.2021.1887720
Qu, Zhi, Wong, Kuan Yau, Moniruzzaman, Md., Begun, Jakob, Santos, Hélder A, Hasnain, Sumaira Z., Kumeria, Tushar, McGuckin, Michael A. and Popat, Amirali (2020). One‐pot synthesis of pH‐responsive eudragit‐mesoporous silica nanocomposites enable colonic delivery of glucocorticoids for the treatment of inflammatory bowel disease. Advanced Therapeutics, 4 (2) 2000165, 2000165. doi: 10.1002/adtp.202000165
Sheng, Yong H., Ng, Garrett Z., Summers, Kim M., Every, Alison L., Price, Gareth, Hasnain, Sumaira Z., Sutton, Philip and McGuckin, Michael A. (2020). Influence of the MUC1 cell surface mucin on gastric mucosal gene expression profiles in response to Helicobacter pylori infection in mice. Frontiers in Cellular and Infection Microbiology, 10 343, 343. doi: 10.3389/fcimb.2020.00343
Ramos, Joyce S., Dalleck, Lance C., Stennett, Rebecca C., Mielke, Gregore I., Keating, Shelley E., Murray, Lydia S., Hasnain, Sumaira Z., Fassett, Robert G., McGuckin, Michael, Croci, Ilaria and Coombes, Jeff S. (2020). Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 13, 2443-2453. doi: 10.2147/dmso.s251567
Pujara, Naisarg, Wong, Kuan Yau, Qu, Zhi, Wang, Ran, Moniruzzaman, Md., Rewatkar, Prarthana, Kumeria, Tushar, Ross, Benjamin P., McGuckin, Michael and Popat, Amirali (2020). Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis. Molecular Pharmaceutics, 18 (2) acs.molpharmaceut.0c00048, 627-640. doi: 10.1021/acs.molpharmaceut.0c00048
Airway mucus hyperconcentration in non–cystic fibrosis bronchiectasis
Ramsey, Kathryn A., Chen, Alice C. H., Radicioni, Giorgia, Lourie, Rohan, Martin, Megan, Broomfield, Amy, Sheng, Yong H., Hasnain, Sumaira Z., Radford-Smith, Graham, Simms, Lisa A., Burr, Lucy, Thornton, David J., Bowler, Simon D., Livengood, Stephanie, Ceppe, Agathe, Knowles, Michael R., Noone, Peadar G., Donaldson, Scott H., Hill, David B., Ehre, Camille, Button, Brian, Alexis, Neil E., Kesimer, Mehmet, Boucher, Richard C. and McGuckin, Michael A. (2020). Airway mucus hyperconcentration in non–cystic fibrosis bronchiectasis. American Journal of Respiratory and Critical Care Medicine, 201 (6), 661-670. doi: 10.1164/rccm.201906-1219OC
Effect of MUC1 length polymorphisms on the NLRP3 inflammasome response of human macrophages
Dhar, Poshmaal, Sarkar, Sohinee, Ng, Garrett Z., Kalitsis, Paul, Saeed, Muhammad A., McGuckin, Michael A., Ellis, Justine A. and Sutton, Philip (2019). Effect of MUC1 length polymorphisms on the NLRP3 inflammasome response of human macrophages. Human Immunology, 80 (10), 878-882. doi: 10.1016/j.humimm.2019.06.001
Chaudhary, Zanib, Khan, Gul Majid, Abeer, Muhammad Mustafa, Pujara, Naisarg, Wan-Chi Tse, Brian, McGuckin, Michael A., Popat, Amirali and Kumeria, Tushar (2019). Efficient photoacoustic imaging using indocyanine green (ICG) loaded functionalized mesoporous silica nanoparticles. Biomaterials Science, 7 (12), 5002-5015. doi: 10.1039/c9bm00822e
Lubrication by biomacromolecules: mechanisms and biomimetic strategies
Pradal, Clementine, Yakubov, Gleb E., Williams, Martin A. K., McGuckin, Michael A. and Stokes, Jason R. (2019). Lubrication by biomacromolecules: mechanisms and biomimetic strategies. Bioinspiration & Biomimetics, 14 (5) 051001, 051001. doi: 10.1088/1748-3190/ab2ac6
He, Yaowu, Davies, Claire M., Harrington, Brittney S., Hellmers, Linh, Sheng, Yonghua, Broomfield, Amy, McGann, Thomas, Bastick, Kate, Zhong, Laurie, Wu, Andy, Maresh, Grace, McChesney, Shannon, Yau Wong, Kuan, Adams, Mark N., Sullivan, Ryan C., Palmer, James S., Burke, Lez J., Ewing, Adam D., Zhang, Xin, Margolin, David, Li, Li, Lourie, Rohan, Matsika, Admire, Srinivasan, Bhuvana, McGuckin, Michael A., Lumley, John W. and Hooper, John D. (2019). CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin. Oncogene, 39 (1), 219-233. doi: 10.1038/s41388-019-0983-3
MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity
Sheng, Yong Hua, Wong, Kuan Yau, Seim, Inge, Wang, Ran, He, Yaowu, Wu, Andy, Patrick, Maya, Lourie, Rohan, Schreiber, Veronika, Giri, Rabina, Ng, Choa Ping, Popat, Amirali, Hooper, John, Kijanka, Gregor, Florin, Timothy H., Begun, Jakob, Radford, Kristen J., Hasnain, Sumaira and McGuckin, Michael A. (2019). MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity. Oncogene, 38 (48), 7294-7310. doi: 10.1038/s41388-019-0951-y
Moniruzzaman, Md., Wang, Ran, Jeet, Varinder, McGuckin, Michael A. and Hasnain, Sumaira Z. (2019). Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway. International Journal of Molecular Sciences, 20 (14) 3468, 3468. doi: 10.3390/ijms20143468
Responsive polysaccharide-grafted surfaces for biotribological applications
Pradal, Clementine, Yakubov, Gleb E., Williams, Martin A.K., McGuckin, Michael A. and Stokes, Jason R. (2019). Responsive polysaccharide-grafted surfaces for biotribological applications. Biotribology, 18 100092, 100092. doi: 10.1016/j.biotri.2019.100092
Torquati, Luciana, Coombes, Jeff S., Murray, Lydia, Hasnain, Sumaira Z., Mallard, Alistair R., McGuckin, Michael A., Fassett, Robert G., Croci, Ilaria and Ramos, Joyce S. (2019). Fibre intake is independently associated with increased circulating interleukin-22 in individuals with metabolic syndrome. Nutrients, 11 (4) 815, 815. doi: 10.3390/nu11040815
Shen, Kunyu, Vesey, David A., Ellis, Robert J., Del Vecchio, Sharon Juliet, Cho, Yeoungjee, Teixeira-Pinto, Armando, McGuckin, Michael A., Johnson, David W. and Gobe, Glenda C. (2019). GRP78 expression in tumor and perinephric adipose tissue is not an optimal risk stratification marker for clear cell renal cell carcinoma. PLoS One, 14 (1) e0210246, e0210246. doi: 10.1371/journal.pone.0210246
Hartley-Tassell, L. E., Day, C. J., Semchenko, E. A., Tram, G., Calderon-Gomez, L. I., Klipic, Z., Barry, A. M., Lam, A. K., McGuckin, M. A. and Korolik, V. (2018). A peculiar case of Campylobacter jejuni attenuated aspartate chemosensory mutant, able to cause pathology and inflammation in avian and murine model animals. Scientific Reports, 8 (1) 12594. doi: 10.1038/s41598-018-30604-5
Burr, Lucy D., Rogers, Geraint B., Chen, Alice C.-H., Taylor, Steven L., Bowler, Simon D., Keating, Rebecca L., Martin, Megan L., Hasnain, Sumaira Z. and McGuckin, Michael A. (2018). PPARγ is reduced in the airways of non-CF bronchiectasis subjects and is inversely correlated with the presence of Pseudomonas aeruginosa. PLoS ONE, 13 (8) e0202296, e0202296. doi: 10.1371/journal.pone.0202296
Ó Cuív, Páraic, Giri, Rabina, Hoedt, Emily C., McGuckin, Michael A., Begun, Jakob and Morrison, Mark (2018). Enterococcus faecalis AHG0090 is a genetically tractable bacterium and produces a secreted peptidic bioactive that suppresses nuclear factor Kappa B activation in human gut epithelial cells. Frontiers in Immunology, 9 (April) 790, 790. doi: 10.3389/fimmu.2018.00790
Medrum, Oliver W., Yakubov, Gleb E., Bonilla, Mauricio R., Deshmukh, Omkar, McGuckin, Michael A. and Gidley, Michael J. (2018). Mucin gel assembly is controlled by a collective action of non-mucin proteins, disulfide bridges, Ca2+- mediated links, and hydrogen bonding. Scientific Reports, 8 (1) 5802, 5802. doi: 10.1038/s41598-018-24223-3
Oxidative and endoplasmic reticulum stress in respiratory disease
Chen, Alice C-H, Burr, Lucy and McGuckin, Michael A. (2018). Oxidative and endoplasmic reticulum stress in respiratory disease. Clinical and Translational Immunology, 7 (6) e1019, e1019. doi: 10.1002/cti2.1019
Fercher, Christian, Keshvari, Sahar, McGuckin, Michael A and Barnard, Ross T (2017). Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins. Experimental biology and medicine (Maywood, N.J.), 243 (2), 166-183. doi: 10.1177/1535370217748575
Meldrum, Oliver W, Yakubov, Gleb E, Gartaula, Ghanendra, McGuckin, Michael A and Gidley, Michael J (2017). Mucoadhesive functionality of cell wall structures from fruits and grains: Electrostatic and polymer network interactions mediated by soluble dietary polysaccharides. Scientific reports, 7 (1) 15794, 1-15. doi: 10.1038/s41598-017-16090-1
Infection's Sweet Tooth: How Glycans Mediate Infection and Disease Susceptibility
Taylor, Steven L., McGuckin, Michael A., Wesselingh, Steve and Rogers, Geraint B. (2017). Infection's Sweet Tooth: How Glycans Mediate Infection and Disease Susceptibility. Trends in Microbiology, 26 (2), 92-101. doi: 10.1016/j.tim.2017.09.011
Shen, Kunyu, Johnson, David W., Vesey, David A., McGuckin, Michael A. and Gobe, Glenda C. (2017). Role of the unfolded protein response in determining the fate of tumor cells and the promise of multi-targeted therapies. Cell Stress and Chaperones, 23 (3), 317-334. doi: 10.1007/s12192-017-0844-3
Goblet cells as mucosal sentinels for immunity
McGuckin, M. A. and Hasnain, S. Z. (2017). Goblet cells as mucosal sentinels for immunity. Mucosal Immunology, 10 (5), 1118-1121. doi: 10.1038/mi.2016.132
The effect of interleukin-22 treatment on autoimmune diabetes in the NOD mouse
Borg, Danielle J., Wang, Ran, Murray, Lydia, Tong, Hui, Steptoe, Raymond J., McGuckin, Michael A. and Hasnain, Sumaira Z. (2017). The effect of interleukin-22 treatment on autoimmune diabetes in the NOD mouse. Diabetologia, 60 (11), 1-6. doi: 10.1007/s00125-017-4392-2
Nguyen, Chau T. H., Webb, Richard I., Lambert, Lynette K., Strounina, Ekaterina, Lee, Edward C., Parat, Marie-Odile, McGuckin, Michael A., Popat, Amirali, Cabot, Peter J. and Ross, Benjamin P. (2017). Bifunctional succinylated ε-polylysine-coated mesoporous silica nanoparticles for pH-responsive and intracellular drug delivery targeting the colon. ACS Applied Materials and Interfaces, 9 (11), 9470-9483. doi: 10.1021/acsami.7b00411
The cell surface mucin MUC1 limits the severity of influenza A virus infection
McAuley, J. L., Corcilius, L., Tan, H. -X., Payne, R. J., McGuckin, M. A. and Brown, L. E. (2017). The cell surface mucin MUC1 limits the severity of influenza A virus infection. Mucosal Immunology, 10 (6), 1581-1593. doi: 10.1038/mi.2017.16
Is there a link between H. Pylori and the epidemiology of Crohn’s disease?
Shah, Ayesha, Talley, Nicholas J., Walker, Marjorie, Koloski, Natasha, Morrison, Mark, Burger, Daniel, Andrews, Jane M., McGuckin, Michael, Jones, Mike and Holtmann, Gerald (2017). Is there a link between H. Pylori and the epidemiology of Crohn’s disease?. Digestive Diseases and Sciences, 62 (9), 1-9. doi: 10.1007/s10620-017-4496-z
Sheng, Yonghua, Ng, Choa Ping, Lourie, Rohan, Shah, Esha T., He, Yaowu, Wong, Kuan Yua, Seim, Inge, Oancea, Iulia, Morais, Christudas, Jeffery, Penny L., Hooper, John, Gobe, Glenda C. and Mcguckin, Michael A. (2017). MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance. International Journal of Cancer, 140 (10), 2351-2363. doi: 10.1002/ijc.30651
Hasnain, Sumaira Z., Dawson, Paul A., Lourie, Rohan, Hutson, Peter, Tong, Hui, Grencis, Richard K., McGuckin, Michael A. and Thornton, David J. (2017). Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion. PLoS Pathogens, 13 (2) e1006218, e1006218. doi: 10.1371/journal.ppat.1006218
Pujara, Naisarg, Jambhrunkar, Siddharth, Wong, Kuan Yau, McGuckin, Michael and Popat, Amirali (2017). Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate. Journal of Colloid and Interface Science, 488, 303-308. doi: 10.1016/j.jcis.2016.11.015
Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome
Varelias, Antiopi, Ormerod, Kate L., Bunting, Mark D., Koyama, Motoko, Gartlan, Kate H., Kuns, Rachel D., Lachner, Nancy, Locke, Kelly R., Lim, Chun Y., Henden, Andrea S., Zhang, Ping, Clouston, Andrew D., Hasnain, Sumaira Z., McGuckin, Michael A., Blazar, Bruce R., MacDonald, Kelli P. A ., Hugenholtz, Philip and Hill, Geoffrey R. (2017). Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome. Blood, 129 (15), 2172-2185. doi: 10.1182/blood-2016-08-732628
Burr, Lucy D., Rogers, Geraint B., Chen, Alice C.-H., Hamilton, Brett R., Pool, Gertruida F., Taylor, Steven L., Venter, Deon, Bowler, Simon D., Biga, Sally and McGuckin, Michael A. (2016). Macrolide treatment inhibits Pseudomonas aeruginosa quorum sensing in non-cystic fibrosis bronchiectasis. An analysis from the bronchiectasis and low-dose erythromycin study trial. Annals of the American Thoracic Society, 13 (10), 1697-1703. doi: 10.1513/AnnalsATS.201601-044OC
Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol
Summerlin, Natalie, Qu, Zhi, Pujara, Naisarg, Sheng, Yong, Jambhrunkar, Siddharth, McGuckin, Michael and Popat, Amirali (2016). Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol. Colloids and Surfaces B: Biointerfaces, 144 (4), 1-7. doi: 10.1016/j.colsurfb.2016.03.076
Sheng, Y. H., He, Y., Hasnain, S. Z., Wang, R., Tong, H., Clarke, D. T., Lourie, R., Oancea, I., Wong, K. Y., Lumley, J. W., Florin, T. H., Sutton, P., Hooper, J. D., McMillan, N. A. and McGuckin, M. A. (2016). MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target. Oncogene, 36 (5), 700-713. doi: 10.1038/onc.2016.241
High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22
Gulhane, Max, Murray, Lydia, Lourie, Rohan, Tong, Hui, Sheng, Yong H., Wang, Ran, Kang, Alicia, Schreiber, Veronika, Wong, Kuan Yau, Magor, Graham, Denman, Stuart, Begun, Jakob, Florin, Timothy H., Perkins, Andrew, Cuiv, Paraic O., McGuckin, Michael A. and Hasnain, Sumaira Z. (2016). High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22. Scientific Reports, 6 (1) 28990, 28990. doi: 10.1038/srep28990
Epithelial sel1L is required for the maintenance of intestinal homeostasis
Sun, Shengyi, Lourie, Rohan, Cohen, Sara B., Ji, Yewei, Goodrich, Julia K., Poole, Angela C., Ley, Ruth E., Denkers, Eric Y., McGuckin, Michael A., Long, Qiaoming, Duhamel, Gerald E., Simpson, Kenneth W. and Qi, Ling (2016). Epithelial sel1L is required for the maintenance of intestinal homeostasis. Molecular Biology of the Cell, 27 (3), 483-490. doi: 10.1091/mbc.E15-10-0724
Oxidative and endoplasmic reticulum stress in beta-cell dysfunction in diabetes
Hasnain, Sumaira Z., Prins, Johannes B. and McGuckin, Michael A. (2016). Oxidative and endoplasmic reticulum stress in beta-cell dysfunction in diabetes. Journal of Molecular Endocrinology, 56 (2), R33-R54. doi: 10.1530/jme-15-0232
Taylor, Steven L., Woodman, Richard J., Chen, Alice C. H., Burr, Lucy D., Gordon, David L., McGuckin, Michael A., Wesselingh, Steve and Rogers, Geraint B. (2016). FUT2 genotype influences lung function, exacerbation frequency and airway microbiota in non-CF bronchiectasis. Thorax, 72 (4), 304-310. doi: 10.1136/thoraxjnl-2016-208775
Taylor, Steven L., Rogers, Geraint B., Chen, Alice C.-H., Burr, Lucy D., McGuckin, Michael A. and Serisier, David J. (2015). Matrix metalloproteinases vary with airway microbiota composition and lung function in non-cystic fibrosis bronchiectasis. Annals of the American Thoracic Society, 12 (5), 701-707. doi: 10.1513/AnnalsATS.201411-513OC
Wang, Ran, Hasnain, Sumaira Z., Tong, Hui, Das, Indrajit, Che-Hao Chen, Alice, Oancea, Iulia, Proctor, Martina, Florin, Timothy H., Eri, Rajaraman D. and McGuckin, Michael A. (2015). Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model. Inflammatory Bowel Diseases, 21 (5), 973-984. doi: 10.1097/MIB.0000000000000353
Ng, Garrett Z., Menheniott, Trevelyan R., Every, Alison L., Stent, Andrew, Judd, Louise M., Chionh, Yok Teng, Dhar, Poshmaal, Komen, Jasper C., Giraud, Andrew S., Wang, Timothy C., McGuckin, Michael A. and Sutton, Philip (2015). The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome. Gut, 65 (7), 1-13. doi: 10.1136/gutjnl-2014-307175
Adult non-cystic fibrosis bronchiectasis is characterised by airway luminal Th17 pathway activation
Chen, Alice C.-H., Martin, Megan L., Lourie, Rohan, Rogers, Geraint B., Burr, Lucy D., Hasnain, Sumaira Z., Bowler, Simon D., McGuckin, Michael A. and Serisier, David J. (2015). Adult non-cystic fibrosis bronchiectasis is characterised by airway luminal Th17 pathway activation. PLoS ONE, 10 (3) e0119325, e0119325. doi: 10.1371/journal.pone.0119325
Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonghua H., Ng, Choa Ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014). Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12), 1417-1426. doi: 10.1038/nm.3705
Rehaume, Linda, Mondot, Stanislas, Aguirre de Cárcer, Daniel, Velasco, Jared, Benham, Helen, Hasnain, Sumaira Zia, Bowman, Jaclyn, Ruutu, Merja, Hansbro, Philip M., McGuckin, Michael, Morrison, Mark and Thomas, Ranjeny (2014). ZAP-70 genotype disrupts the relationship between microbiota and host leading to spondyloarthritis and ileitis in SKG Mice. Arthritis and Rheumatology, 66 (10), 2780-2792. doi: 10.1002/art.38773
Benham, Helen, Rehaume, Linda M., Hasnain, Sumaira Z., Velasco, Jared, Baillet, Athan C., Ruutu, Merja, Kikly, Kristine, Wang, Ran, Tseng, Hsu-Wen, Thomas, Gethin P., Brown, Matthew A., Strutton, Geoffrey, McGuckin, Michael A. and Thomas, Ranjeny (2014). Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis and Rheumatology, 66 (7), 1755-1767. doi: 10.1002/art.38638
Rogers, G. B., Kozlowska, J., Keeble, J., Metcalfe, K., Fao, M., Dowd, S. E., Mason, A. J., McGuckin, M. A. and Bruce, K. D. (2014). Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice. Scientific Reports, 4 (1) 5437. doi: 10.1038/srep05437
A novel microbiota stratification system predicts future exacerbations in bronchiectasis
Rogers, Geraint B., Zain, Nur Masirah M., Bruce, Kenneth D., Burr, Lucy D., Chen, Alice C., Rivett, Damian W., McGuckin, Michael A. and Serisier, David J. (2014). A novel microbiota stratification system predicts future exacerbations in bronchiectasis. Annals of the American Thoracic Society, 11 (4), 496-503. doi: 10.1513/AnnalsATS.201310-335OC
Speckmann, Bodo, Gerloff, Kirsten, Simms, Lisa, Oancea, Iulia, Shi, Wei, McGuckin, Michael A., Radford-Smith, Graham and Khanna, Kum Kum (2014). Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells. Free Radical Biology and Medicine, 67, 265-277. doi: 10.1016/j.freeradbiomed.2013.11.001
Navabi, Nazanin, McGuckin, Michael A. and Linden, Sara K. (2013). Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation. PLoS One, 8 (7) e68761, e68761.1-e68761.15. doi: 10.1371/journal.pone.0068761
Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins
Walsh, Michael D., Cummings, Margaret C., Pearson, Sally-Ann, Clendenning, Mark, Walters, Rhiannon J., Nagler, Belinda, Hopper, John L., Jenkins, Mark A., Suthers, Graeme K., Goldblatt, Jack, Tucker, Kathy, Gattas, Michael R., Arnold, Julie L., Parry, Susan, Macrae, Finlay A., McGuckin, Michael A., Young, Joanne P. and Buchanan, Daniel D. (2013). Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins. Modern Pathology, 26 (7), 944-954. doi: 10.1038/modpathol.2012.232
Das, Indrajit, Png, Chin Wen, Oancea, Iulia, Hasnain, Sumaira Z., Lourie, Rohan, Proctor, Martina, Eri, Rajaraman D., Sheng, Yong, Crane, Denis I., Florin, Timothy H. and McGuckin, Michael A. (2013). Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins. Journal of Experimental Medicine, 210 (6), 1201-1216. doi: 10.1084/jem.20121268
Sheng, Y. H., Triyana, S., Wang, R., Das, I., Gerloff, K., Florin, T. H., Sutton, P. and McGuckin, M. A. (2013). MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli. Mucosal Immunology, 6 (3), 557-568. doi: 10.1038/mi.2012.98
Gorrell, Rebecca J., Guan, Jyeswei, Xin, Yue, Tafreshi, Mona Anoushiravani, Hutton, Melanie L., McGuckin, Michael A., Ferrero, Richard L. and Kwok, Terry (2013). A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by the Helicobacter pylori type IV secretion system. Cellular Microbiology, 15 (4), 554-570. doi: 10.1111/cmi.12055
Oancea, Iulia, Png, Chin Wen, Das, Indrajit, Lourie, Rohan, Winkler, Ingrid G., Eri, Rajaraman, Subramaniam, Nathan, Jinnah, H. A., McWhinney, Brett C., Levesque, Jean-Pierre, McGuckin, Michael A., Duley, John A. and Florin, Timothy H. J. (2013). A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity. Gut, 62 (4), 594-605. doi: 10.1136/gutjnl-2012-302274
Sina, Christian, Lipinski, Simone, Gavrilova, Olga, Aden, Konrad, Rehman, Ateequr, Till, Andreas, Rittger, Andrea, Podschun, Rainer, Meyer-Hoffert, Ulf, Haesler, Robert, Midtling, Emilie, Puetsep, Katrin, McGuckin, Michael A., Schreiber, Stefan, Saftig, Paul and Rosenstiel, Philip (2013). Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice. Gut, 62 (4), 520-530. doi: 10.1136/gutjnl-2011-300076
Serisier, David J., Martin, Megan L., McGuckin, Michael A., Lourie, Rohan, Chen, Alice C., Brain, Barbara, Biga, Sally, Schlebusch, Sanmarié, Dash, Peter and Bowler, Simon D. (2013). Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial. JAMA: The Journal of the American Medical Association, 309 (12), 1260-1267. doi: 10.1001/jama.2013.2290
King, Rebecca M., Day, Christopher J., Hartley-Tassell, Lauren E., Connerton, Ian F., Tiralongo, Joe, McGuckin, Michael A. and Korolik, Victoria (2013). Carbohydrate binding and gene expression by in vitro and in vivo propagated Campylobacter jejuni after Immunomagnetic Separation. Journal of Basic Microbiology, 53 (3), 240-250. doi: 10.1002/jobm.201100466
Dong, Ying, Stephens, Carson, Walpole, Carina, Swedberg, Joakim E., Boyle, Glen M., Parsons, Peter G., McGuckin, Michael A., Harris, Jonathan M. and Clements, Judith A. (2013). Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment. PLoS One, 8 (2) e57056, e57056.1-e57056.12. doi: 10.1371/journal.pone.0057056
Hasnain, Sumaira Z., Tauro, Sharyn, Das, Indrajit, Tong, Hui, Chen, Alice C. -H., Jeffery, Penny L., McDonald, Victoria, Florin, Timothy H. and McGuckin, Michael A. (2013). IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology, 144 (2), 357-368. doi: 10.1053/j.gastro.2012.10.043
There is a 'uc' in mucus, but is there mucus in UC?
McGuckin, Michael A. and Hasnain, Sumaira Z. (2013). There is a 'uc' in mucus, but is there mucus in UC?. Gut, 63 (2), 216-217. doi: 10.1136/gutjnl-2013-304602
Walsh, Michael D., Clendenning, Mark, Williamson, Elizabeth, Pearson, Sally-Ann, Walters, Rhiannon J., Nagler, Belinda, Packenas, David, Win, Aung K., Hopper, John L., Jenkins, Mark A., Haydon, Andrew M., Rosty, Christophe, English, Dallas R., Giles, Graham G., McGuckin, Michael A., Young, Joanne P. and Buchanan, Daniel D. (2013). Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype. Modern Pathology, 26 (12), 1642-1656. doi: 10.1038/modpathol.2013.101
Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier
Hasnain, Sumaira Z., McGuckin, Michael A., Grencis, Richard K. and Thornton, David J. (2012). Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier. PLoS Neglected Tropical Diseases, 6 (10) e1856, e1856.1-e1856.13. doi: 10.1371/journal.pntd.0001856
Karlsson, Niclas G. and McGuckin, Michael A. (2012). O-Linked glycome and proteome of high-molecular-mass proteins in human ovarian cancer ascites: Identification of sulfation, disialic acid and O-linked fucose. Glycobiology, 22 (7), 918-929. doi: 10.1093/glycob/cws060
β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice
Ruutu, Merja, Thomas, Gethin, Steck, Roland, Degli-Esposti, Mariapia A., Zinkernagel, Martin S., Alexander, Kylie, Velasco, Jared, Strutton, Geoffrey, Tran, Ai, Benham, Helen, Rehaume, Linda, Wilson, Robert J., Kikly, Kristine, Davies, Julian, Pettit, Allison R., Brown, Matthew A., McGuckin, Michael A. and Thomas, Ranjeny (2012). β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice. Arthritis and Rheumatism, 64 (7), 2211-2222. doi: 10.1002/art.34423
The interplay between endoplasmic reticulum stress and inflammation
Hasnain, Sumaira Z ., Lourie, Rohan, Das, Indrajit, Chen, Alice C-H. and McGuckin, Michael A. (2012). The interplay between endoplasmic reticulum stress and inflammation. Immunology and Cell Biology, 90 (3), 260-270. doi: 10.1038/icb.2011.112
Mucins in inflammatory bowel diseases and colorectal cancer
Sheng, Yong H., Hasnain, Sumaira Z., Florin, Timothy H. J. and McGuckin, Michael A. (2012). Mucins in inflammatory bowel diseases and colorectal cancer. Journal of Gastroenterology and Hepatology, 27 (1), 28-38. doi: 10.1111/j.1440-1746.2011.06909.x
Preface: introduction to mucin biology and technical challenges of mucin research
McGuckin, Michael A. and Thornton, David J. (2012). Preface: introduction to mucin biology and technical challenges of mucin research. Mucins: Methods and Protocols, 842.
Sheng, Yong H., Lourie, Rohan, Linden, Sara K., Jeffery, Penny L., Roche, Deborah, Tran, Thu V., Png, Chin W., Waterhouse, Nigel, Sutton, Philip, Florin, Timothy H. J. and McGuckin, Michael A. (2011). The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis. Gut, 60 (12), 1661-1670. doi: 10.1136/gut.2011.239194
Localized suppression of inflammation at sites of Helicobacter pylori colonization
Every, Alison L., Ng, Garrett Z., Skene, Caroline D., Harbour, Stacey N., Walduck, Anna K., McGuckin, Michael A. and Sutton, Philip (2011). Localized suppression of inflammation at sites of Helicobacter pylori colonization. Infection and Immunity, 79 (10), 4186-4192. doi: 10.1128/IAI.05602-11
Ghrelin in gastrointestinal disease
Jeffery, Penny, McDonald, Victoria, Tippett, Emma and McGuckin, Michael (2011). Ghrelin in gastrointestinal disease. Molecular and Cellular Endocrinology, 340 (1), 35-43. doi: 10.1016/j.mce.2011.03.002
Eri, R. D., Adams, R. J., Tran, T. V., Tong. H., Das. I., Roche, D. K., Oancea, I., Png, C. W., Jeffery, P. L., Radford-Smith, G.L., Cook, M. C., Florin, T. H. and McGuckin, M. A. (2011). An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity. Mucosal Immunology, 4 (3), 354-364. doi: 10.1038/mi.2010.74
Endocrine impact of Helicobacter pylori: focus on ghrelin and ghrelin o-acyltransferase
Jeffery, Penny L., McGuckin, Michael A. and Linden, Sara K. (2011). Endocrine impact of Helicobacter pylori: focus on ghrelin and ghrelin o-acyltransferase. World Journal of Gastroenterology, 17 (10), 1249-1260. doi: 10.3748/wjg.v17.i10.1249
No evidence of the unfolded protein response in patients with chronic hepatitis C virus infection
McPherson, Stuart, Powell, Elizabeth E., Barrie, Helen D., Clouston, Andrew D., McGuckin, Michael and Jonsson, Julie R. (2011). No evidence of the unfolded protein response in patients with chronic hepatitis C virus infection. Journal of Gastroenterology and Hepatalogy, 26 (2), 319-327. doi: 10.1111/j.1440-1746.2010.06368.x
Mucin dynamics and enteric pathogens
McGuckin, Michael A., Linden, Sara K., Sutton, Philip and Florin, Timothy H. (2011). Mucin dynamics and enteric pathogens. Nature Reviews Microbiology, 9 (4), 265-278. doi: 10.1038/nrmicro2538
Png, CW, Linden, SK, Gilshenan, KS, Zoetendal, EG, McSweeney, CS, Sly, LI, McGuckin, MA and Florin, THJ (2010). Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria. American Journal of Gastroenterology, 105 (11), 2420-2428. doi: 10.1038/ajg.2010.281
Simms, Lisa A., Doecke, James D., Roberts, Rebecca L., Fowler, Elizabeth V., Zhao, Zhen Zhen, McGuckin, Michael A., Huang, Ning, Hayward, Nicholas K., Webb, Penelope M., Whiteman, David C., Cavanaugh, Juleen A., McCallum, Ruth, Florin, Timothy H. J., Barclay, Murray L., Gearry, Richard B., Merriman, Tony R., Montgomery, Grant W. and Radford-Smith, Graham L. (2010). KCNN4 gene variant is associated with ileal Crohn's disease in the Australian and New Zealand population. American Journal of Gastroenterology, 105 (10), 2209-2217. doi: 10.1038/ajg.2010.161
Aberrant mucin glycoprotein patterns of chronic rhinosinusitis patients with bacterial biofilms
Tan, Lorwai, Psaltis, Alkis, Baker, Leonie M., Mcguckin, Mike, Rousseau, Karine and Wormald, Peter-John (2010). Aberrant mucin glycoprotein patterns of chronic rhinosinusitis patients with bacterial biofilms. American Journal of Rhinology & Allergy, 24 (5), 319-324. doi: 10.2500/ajra.2010.24.3504
ER stress and the unfolded protein response in intestinal inflammation
McGuckin, Michael A., Eri, Rajaraman D., Das, Indrajit, Lourie, Rohan and Florin, Timothy H. (2010). ER stress and the unfolded protein response in intestinal inflammation. American Journal of Physiology: Gastrointestinal and Liver Physiology, 298 (6), G820-G832. doi: 10.1152/ajpgi.00063.2010
Walsh, MD, Buchanan, DD, Cummings, MC, Pearson, SA, Arnold, ST, Clendenning, M, Walters, R, McKeone, DM, Spurdle, AB, Hopper, JL, Jenkins, MA, Phillips, KD, Suthers, GK, George, J, Goldblatt, J, Muir, A, Tucker, K, Pelzer, E, Gattas, MR, Woodall, S, Parry, S, Macrae, FA, Haile, RW, Baron, JA, Potter, JD, Le Marchand, L, Bapat, B, Thibodeau, SN, Lindor, NM ... Young, JP (2010). Lynch syndrome-associated breast cancers: Clinicopathologic characteristics of a case series from the colon cancer family registry. Clinical Cancer Research, 16 (7), 2214-2224. doi: 10.1158/1078-0432.CCR-09-3058
Linden, Sara K., Sheng, Yong H., Every, Alison L., Miles, Kim M., Skoog, Emma C., Florin, Timothy H.J., Sutton, Philip and Mcguckin, Michael A. (2009). MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy. Plos Pathogens, 5 (10), Article No. e1000617. doi: 10.1371/journal.ppat.1000617
Dawson, Paul A., Huxley, S., Gardiner, B., Tran, T., McAuley, J. L., Grimmond, S. M., McGuckin, M. A. and Markovich, D. (2009). Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse. Gut, 58 (7), 910-919. doi: 10.1136/gut.2007.147595
Dietary Antigens in Crohn's Disease
Adams, Rachael, McGuckin, Michael and Florin, Timothy (2009). Dietary Antigens in Crohn's Disease. The American Journal of Gastroenterology, 104 (2), 526-526. doi: 10.1038/ajg.2008.79
Mucin I (MUCI) is a novel partner for MAL2 in breast carcinoma cells
Fanayan, Susan, Shehata, Mona, Agterof, Annelies P., Mcguckin, Michael A., Alonso, Miguel A . and Byrne, Jennifer A. (2009). Mucin I (MUCI) is a novel partner for MAL2 in breast carcinoma cells. BMC Cell Biology, 10 (7) 7, 7-1-7-13. doi: 10.1186/1471-2121-10-7
Intestinal barrier dysfunction in inflammatory bowel diseases
McGuckin, Michael A., Eri, Rajaraman, Simms, Lisa A., Florin, Timothy H. J. and Radford-Smith, Graham (2009). Intestinal barrier dysfunction in inflammatory bowel diseases. Inflammatory Bowel Diseases, 15 (1), 100-113. doi: 10.1002/ibd.20539
Every, Alison L., Chionh, Yok-Teng, Skene, Caroline D., McGuckin, Michael A. and Sutton, Philip (2008). Muc1 limits Helicobacter felis binding to gastric epithelial cells but does not limit colonization and gastric pathology following infection. Helicobacter, 13 (6), 489-493. doi: 10.1111/j.1523-5378.2008.00644.x
Tu, Quoc V., McGuckin, Michael A. and Mendz, George L. (2008). Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants. Journal of Medical Microbiology, 57 (7), 795-802. doi: 10.1099/jmm.0.47752-0
Listeria monocytogenes internalins bind to the human intestinal mucin MUC2
Linden, Sara K., Bierne, Hélène, Sabet, Christophe, Png, Chin Wen, Florin, Timothy H., McGuckin, Michael A. and Cossart, Pascale (2008). Listeria monocytogenes internalins bind to the human intestinal mucin MUC2. Archives of Microbiology, 190 (1), 101-104. doi: 10.1007/s00203-008-0358-6
Mucins in the mucosal barrier to infection
Linden, S. K., Sutton, P., Karlsson, N.G., Korolik, V. and McGuckin, M. A. (2008). Mucins in the mucosal barrier to infection. Mucosal Immunology, 1 (3), 183-197. doi: 10.1038/mi.2008.5
Heazlewood, Chad K., Cook, Matthew C., Eri, Rajaraman, Price, Gareth R., Tauro, Sharyn B., Taupin, Douglas, Thornton, David J., Png, Chin Wen, Crockford, Tanya L., Cornall, Richard J., Adams, Rachel, Kato, Masato, Nelms, Keats A., Hong, Nancy A., Florin, Timothy H. J., Goodnow, Christopher C. and McGuckin, Michael A. (2008). Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Medicine, 5 (3) e54, 440-460. doi: 10.1371/journal.pmed.0050054
Mucin dynamics in intestinal bacterial infection
Linden, Sara K., Florin, Timothy H. J. and McGuckin, Michael A. (2008). Mucin dynamics in intestinal bacterial infection. PLoS One, 3 (12) e3952, e3952.1-e3952.14. doi: 10.1371/journal.pone.0003952
Structure and function of the polymeric mucins in airways mucus
Thornton, David J., Rousseau, Karine and McGuckin, Michael A. (2008). Structure and function of the polymeric mucins in airways mucus. Annual Review of Physiology, 70 (1), 459-486. doi: 10.1146/annurev.physiol.70.113006.100702
Adams, Rachel J., Heazlewood, Sharise P., Gilshenan, Kristen S., O'Brien, Mark, McGuckin, Michael A. and Florin, Timothy H. J. (2008). IgG Antibodies Against Common Gut Bacteria Are More Diagnostic for Crohn's Disease Than IgG Against Mannan or Flagellin. American Journal of Gastroenterology, 103 (2), 386-396. doi: 10.1111/j.1572-0241.2007.01577.x
Adams, Rachel J., Heazlewood, Sharise P., Gilshenan, Kristen S., O'Brien, Mark, McGuckin, Michael A. and Florin, Timothy H. J. (2008). IgG antibodies against common gut bacteria are more diagnostic for Crohn's disease than IgG against mannan or flagellin. American Journal of Gastroenterology, 103 (2), 386-396. doi: 10.1111/j.1572-0241.2007.01577.x
McGuckin, Michael A., Every, Alison L., Skene, Caroline D., Linden, Sara K., Chionh, Yok Teng, Swierczak, Agnieszka, McAuley, Julie, Harbour, Stacey, Kaparakis, Maria, Ferrero, Richard and Sutton, Philip (2007). Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis. Gastroenterology, 133 (4), 1210-1218. doi: 10.1053/j.gastro.2007.07.003
Linden, Sara K., Driessen, Kim M. and McGuckin, Michael A. (2007). Improved in vitro model systems for gastrointestinal infection by choice of cell line, pH, microaerobic conditions, and optimization of culture conditions. Helicobacter, 12 (4), 341-353. doi: 10.1111/j.1523-5378.2007.00509.x
The MUC13 cell surface mucin is highly expressed by human colorectal carcinomas
Walsh, Michael D., Young, Joanne P., Leggett, Barbara A., Williams, Stephanie H., Jass, Jeremy R. and McGuckin, Michael A. (2007). The MUC13 cell surface mucin is highly expressed by human colorectal carcinomas. Human Pathology, 38 (6), 883-892. doi: 10.1016/j.humpath.2006.11.020
MUC1 cell surface mucin is a critical element of the mucosal barrier to infection
McAuley, Julie L., Linden, Sara K., Png, Chin Wen, King, Rebecca M., Pennington, Helen L., Gendler, Sandra J., Florin, Timothy H., Hill, Geoff R., Korolik, Victoria and McGuckin, Michael A. (2007). MUC1 cell surface mucin is a critical element of the mucosal barrier to infection. Journal of Clinical Investigation, 117 (8), 2313-2324. doi: 10.1172/JCI26705
Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer
Pinzon-Charry, A., Ho, C. S. K., Maxwell, T., McGuckin, M. A., Schmidt, C., Furnival, C., Pyke, C. M. and Lopez, J. A. (2007). Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer. British Journal of Cancer, 97 (9), 1251-1259. doi: 10.1038/sj.bjc.6604018
Spontaneous apoptosis of blood dendritic cells in patients with breast cancer
Pinzon-Charry, Alberto, Maxwell, Tammy, McGuckin, Michael A., Schmidt, Chris, Furnival, Colin and Lopez, Jose A. (2006). Spontaneous apoptosis of blood dendritic cells in patients with breast cancer. Breast Cancer Research, 8 (1) R5, R5.1-R5.10. doi: 10.1186/bcr1361
The role of cell surface epithelial mucin (MUC-1) in oropharyngeal candidiasis
Farah, C. S., Ashman, R. B., McGuckin, M. A. and McAuley, J. (2005). The role of cell surface epithelial mucin (MUC-1) in oropharyngeal candidiasis. Australian Dental Journal, 50 (S1), S14-S14. doi: 10.1111/j.1834-7819.2005.tb00377.x
Expression of the cell surface mucin gene family in adenocarcinomas
Packer, L. M., Williams, S. J., Callaghan, S., Gotley, D. C. and McGuckin, M. A. (2004). Expression of the cell surface mucin gene family in adenocarcinomas. International Journal of Oncology, 25 (4), 1119-1126.
Suppressor of cytokine signalling gene expression is elevated in breast carcinoma
Raccurt, M., Tam, S., Lau, W. F. P., Mertani, H. C., Lambert, A., Garcia-Caballero, T., Brown, R. J., McGuckin, M. A., Morel, G. and Waters, M. J. (2003). Suppressor of cytokine signalling gene expression is elevated in breast carcinoma. British Journal of Cancer, 89 (3), 524-532. doi: 10.1038/sj.bjc.6601115
Cummings, M. C., Walsh, M. D., Hohn, B. G, Bennett, I. C., Wright, R. G. and McGuckin, M. A. (2002). Occult Axillary Lymph Node Metastases in Breast Cancer Do Matter: Results of 10-Year Survival Analysis. American Journal of Surgical Pathology, 26 (10), 1286-1295. doi: 10.1097/01.PAS.0000027303.89469.E2
Wreschner, Daniel H., McGuckin, Michael A., Williams, Stefanie J., Baruch, Amos, Yoeli, Merav, Ziv, Ravit, Okun, Liron, Zaretsky, Joseph, Smorodinsky, Nechama, Keydar, Iafa, Neophytou, Pavlos, Stacey, Martin, Lin, His-Shien and Gordon, Siamon (2002). Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins. Protein Science, 11 (3), 698-706. doi: 10.1110/ps.16502
Expression of MUC1 splice variants in benign and malignant ovarian tumours
Obermair, A., Schmid, B. C., Packer, L. M., Leodolter, S., Birner, P., Ward, B. G., Crandon, A. J., McGuckin, M. A. and Zeillinger, R. (2002). Expression of MUC1 splice variants in benign and malignant ovarian tumours. International Journal of Cancer, 100 (2), 166-171. doi: 10.1002/ijc.10456
MUC13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells
Williams, Stephanie J., Wreschner, Daniel H., Mai Tran, Eyre, Helen J., Sutherland, Grant R. and McGuckin, Michael A. (2001). MUC13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells. Journal of Biological Chemistry, 276 (21), 18327-18336. doi: 10.1074/jbc.M008850200
Transactivation-deficient p73 alpha (p73 Delta exon2) inhibits apoptosis and competes with p53
Fillippovich, I., Sorokina, N., Gatei, M., Haupt, Y., Hobson, K., Moallem, E., Spring, K., Mould, M., McGuckin, M. A., Lavin, M. F. and Khanna, K. K. (2001). Transactivation-deficient p73 alpha (p73 Delta exon2) inhibits apoptosis and competes with p53. Oncogene, 20 (4), 514-522. doi: 10.1038/sj.onc.1204118
Quin, RJ and McGuckin, MA (2000). Phosphorylation of the cytoplasmic domain of the MUC1 mucin correlates with changes in cell-cell adhesion. International Journal of Cancer, 87 (4), 499-506. doi: 10.1002/1097-0215(20000815)87:4<499::AID-IJC6>3.0.CO;2-9
Biemer-Huttmann, A. E., Walsh, M. D., McGuckin, M. A., Simms, L. A., Young, J., Leggett, B. A. and Jass, J. R. (2000). Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis. Clinical Cancer Research, 6 (5), 1909-1916.
Combined inhibin and CA125 assays in the detection of ovarian cancer
Robertson, DM, Cahir, N, Burger, HG, Mamers, P, McCloud, PI, Pettersson, K and McGuckin, M (1999). Combined inhibin and CA125 assays in the detection of ovarian cancer. Clinical Chemistry, 45 (5), 651-658. doi: 10.1093/clinchem/45.5.651
Heterogeneity of MUC1 expression by human breast carcinoma cell lines in vivo and in vitro
Walsh, M. D., Luckie, S. M., Cummings, M. C., Antalis, T. M. and McGuckin, M. A. (1999). Heterogeneity of MUC1 expression by human breast carcinoma cell lines in vivo and in vitro. Breast Cancer Research & Treatment, 58 (3), 253-264. doi: 10.1023/A:1006345301364
Biemer-Huttmann, A., Walsh, M. D., McGuckin, M. A., Ajioka, Y., Watanabe, H., Leggett, B. A. and Jass, J. R. (1999). Immunohistochemical staining patterms of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum. Journal of Histochemistry & Cytochemistry, 47 (8), 1039-1047. doi: 10.1177/002215549904700808
The MUC3 gene encodes a transmembrane mucin and is alternatively spliced
Williams, S. J., Munster, D. J., Quin, R. J., Gotley, D. C. and McGuckin, M. A. (1999). The MUC3 gene encodes a transmembrane mucin and is alternatively spliced. Biochemical and Biophysical Research Communication, 261 (1), 83-89. doi: 10.1006/bbrc.1999.1001
Two novel mucin genes down-regulated in colorectal cancer identified by different display
Williams, S., McGuckin, M. A., Gotley, L. D. C., Eyre, H., Sutherland, G. R. and Anatalis, T. (1999). Two novel mucin genes down-regulated in colorectal cancer identified by different display. Cancer Research, 15 (59), 4083-4089.
Two novel mucin genes down-regulated in colorectal cancer identified by differential display
Williams, S., McGuckin, M. A., Gotley, D. C., Eyre, H. J., Sutherland, G. R. and Antalis, T. M. (1999). Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Research, 59 (16), 4083-4089.
Munster, DJ, Quin, RJ, Bansal, AS, Ward, BG and McGuckin, MA (1998). Peritoneal fluid from ovarian cancer patients stimulates MUC1 epithelial mucin expression in ovarian cancer cell lines. International Journal of Cancer, 76 (3), 393-398. doi: 10.1002/(SICI)1097-0215(19980504)76:3<393::AID-IJC17>3.0.CO;2-C
McGuckin, MA, Quin, RJ and Ward, BG (1998). Progesterone stimulates production and secretion of MUC1 epithelial mucin in steroid-responsive breast cancer cell lines. International Journal of Oncology, 12 (4), 939-945. doi: 10.3892/ijo.12.4.939
Richards, ER, Devine, PL, Quin, RJ, Fontenot, JD, Ward, BG and McGuckin, MA (1998). Antibodies reactive with the protein core of MUC1 mucin are present in ovarian cancer patients and healthy women. Cancer Immunology Immunotherapy, 46 (5), 245-252. doi: 10.1007/s002620050484
Expression of MUC1 and MUC2 mucins in epithelial ovarian tumours
Dong, Y, Walsh, MD, Cummings, MC, Wright, RG, Khoo, SK, Parsons, PG and McGuckin, MA (1997). Expression of MUC1 and MUC2 mucins in epithelial ovarian tumours. Journal of Pathology, 183 (3), 311-317. doi: 10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2
Dong, Y, Walsh, MD, McGuckin, MA, Cummings, MC, Gabrielli, BG, Wright, GR, Hurst, T, Khoo, SK and Parsons, PG (1997). Reduced expression of retinoblastoma gene product (pRB) and high expression of p53 are associated with poor prognosis in ovarian cancer. International Journal of Cancer, 74 (4), 407-415. doi: 10.1002/(SICI)1097-0215(19970822)74:4<407::AID-IJC8>3.0.CO;2-Z
Dong, Y, Walsh, MD, McGuckin, MA, Gabrielli, BG, Cummings, MC, Wright, RC, Hurst, T, Khoo, SK and Parsons, PG (1997). Increased expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product p16(INK4A) in ovarian cancer is associated with progression and unfavourable prognosis. International Journal of Cancer, 74 (1), 57-63. doi: 10.1002/(SICI)1097-0215(19970220)74:1<57::AID-IJC10>3.0.CO;2-F
Occult axillary node metastases in breast cancer: Their detection and prognostic significance
McGuckin, M. A., Cummings, M. C., Walsh, M. D., Hohn, B. G., Bennett, I. C. and Wright, R. G. (1996). Occult axillary node metastases in breast cancer: Their detection and prognostic significance. British Journal of Cancer, 73 (1), 88-95. doi: 10.1038/bjc.1996.16
Early steps in the biosynthesis of MUC2 epithelial mucin in colon cancer cells
McGuckin M.A., Devine P.L. and Ward B.G. (1996). Early steps in the biosynthesis of MUC2 epithelial mucin in colon cancer cells. Biochemistry and Cell Biology, 74 (1), 87-93. doi: 10.1139/o96-009
Devine, PL, Walsh, MD, McGuckin, MA, Quin, RJ, Hohn, BG, Claque, A and Samaratunga, H (1995). Prostate-specific antigen (PSA) and cancer-associated serum antigen (CASA) in distinguishing benign and malignant prostate disease. International Journal of Biological Markers, 10 (4), 221-225. doi: 10.1177/172460089501000406
CA15-3, CASA, MSA, AND TPS AS DIAGNOSTIC SERUM MARKERS IN BREAST-CANCER
DEVINE, PL, DUROUX, MA, QUIN, RJ, MCGUCKIN, MA, JOY, GJ, WARD, BG and POLLARD, CW (1995). CA15-3, CASA, MSA, AND TPS AS DIAGNOSTIC SERUM MARKERS IN BREAST-CANCER. Breast Cancer Research and Treatment, 34 (3), 245-251. doi: 10.1007/BF00689716
Prognostic-Significance of Muc1 Epithelial Mucin Expression in Breast-Cancer
McGuckin, MA, Walsh, MD, Hohn, BG, Ward, BG and Wright, RG (1995). Prognostic-Significance of Muc1 Epithelial Mucin Expression in Breast-Cancer. Human Pathology, 26 (4), 432-439. doi: 10.1016/0046-8177(95)90146-9
THE MUCIN MARKER, CASA, IN OVARIAN-CANCER
MCGUCKIN, MA and DEVINE, PL (1995). THE MUCIN MARKER, CASA, IN OVARIAN-CANCER. Tumordiagnostik & Therapie, 16 (1), 1-6.
McGuckin M.A., Hurst T.G. and Ward B.G. (1995). Heterogeneity in production, secretion and glycosylation of MUC1 epithelial mucin by primary cultures of ovarian carcinoma. International Journal of Cancer, 63 (3), 412-418. doi: 10.1002/ijc.2910630319
Predictive value of the combination of serum markers, CA125, CASA and TPS in ovarian cancer
Devine, PL, McGuckin, MA, Quin, RJ and Ward, BG (1995). Predictive value of the combination of serum markers, CA125, CASA and TPS in ovarian cancer. International Journal of Gynecological Cancer, 5 (3), 170-178. doi: 10.1046/j.1525-1438.1995.05030170.x
The mucin marker, CASA, in ovarian cancer
McGuckin M.A. and Devine P.L. (1995). The mucin marker, CASA, in ovarian cancer. Tumor Diagnostik und Therapie, 16 (1), 1-6.
Clark, S, McGuckin, MA, Hurst, T and Ward, BG (1994). Effect of Interferon-Gamma and Tumor-Necrosis-Factor-Alpha On Sensitivity to Cisplatin in Ovarian-Carcinoma Cell-Lines. Cancer Immunology Immunotherapy, 39 (2), 100-104. doi: 10.1007/BF01525315
Serum markers Casa, Cea, Cyfra-21-1, Msa, Nse, Tpa and Tps in lung-cancer
Devine, P.L., Yarker, J.Y., Fong, K.M., McGuckin, M.A., Scells, B., Ward, B.G., Thynne, G.S. and Zimmerman, P.V. (1994). Serum markers Casa, Cea, Cyfra-21-1, Msa, Nse, Tpa and Tps in lung-cancer. International Journal of Oncology, 4 (5), 1129-1135.
Serum markers CASA, CEA, CYFRA 21-1, MSA, NSE, TPA and TPS in lung cancer
Devine, P. L., Yarker, J. Y., Fong, K. M., McGuckin, M. A., Scells, B., Ward, B. G., Thynne, G. S. and Zimmerman, P. V. (1994) Serum markers CASA, CEA, CYFRA 21-1, MSA, NSE, TPA and TPS in lung cancer. International Journal of Oncology, 4 5: 1129-1134.
Mucin Expression by Transitional-Cell Carcinomas of the Bladder
Walsh, MD, Hohn, BG, Thong, W, Devine, PL, Gardiner, RA, Samaratunga, Mlth and McGuckin, MA (1994). Mucin Expression by Transitional-Cell Carcinomas of the Bladder. British Journal of Urology, 73 (3), 256-262. doi: 10.1111/j.1464-410X.1994.tb07514.x
Ward B.G. and McGuckin M.A. (1994). Are CASA and CA125 concentrations in peripheral blood sourced from peritoneal fluid in women with pelvic masses?. Cancer, 73 (6), 1699-1703. doi: 10.1002/1097-0142(19940315)73:6<1699::AID-CNCR2820730624>3.0.CO;2-G
Effect of Interferon-γ and TNF-α on MUC1 Mucin Expression in Ovarian Carcinoma Cell Lines
Clark S., Mcguckin M.A. and Hurst T. (1994). Effect of Interferon-γ and TNF-α on MUC1 Mucin Expression in Ovarian Carcinoma Cell Lines. Disease Markers, 12 (1), 43-50. doi: 10.1155/1994/480236
Factors Effecting the Measurement of Tumor-Associated Muc1 Mucins in Serum
McGuckin, MA, Devine, PL, Ramm, LE and Ward, BG (1994). Factors Effecting the Measurement of Tumor-Associated Muc1 Mucins in Serum. Tumor Biology, 15 (1), 33-44.
Factors effecting the measurement of tumor-associated MUC1 mucins in serum
McGuckin, Michael A., Devine, Peter L., Ramm, Louise E. and Ward, Bruce G. (1994). Factors effecting the measurement of tumor-associated MUC1 mucins in serum. Tumor Biology, 15 (1), 33-44. doi: 10.1159/000217871
Serum markers CASA and CA 15-3 in ovarian cancer: All MUC1 assays are not the same
Devine P.L., McGuckin M.A., Quin R.J. and Ward B.G. (1994). Serum markers CASA and CA 15-3 in ovarian cancer: All MUC1 assays are not the same. Tumor Biology, 15 (6), 337-344. doi: 10.1159/000217910
The cancer-associated serum antigen (CASA) in the management of patients with carcinoma
Devine P.L. and McGuckin M.A. (1994). The cancer-associated serum antigen (CASA) in the management of patients with carcinoma. Australian Journal of Medical Science, 15 (4), 126-132.
EXPRESSION OF MUC2 EPITHELIAL MUCIN IN BREAST-CARCINOMA
WALSH, MD, MCGUCKIN, MA, DEVINE, PL, HOHN, BG and WRIGHT, RG (1993). EXPRESSION OF MUC2 EPITHELIAL MUCIN IN BREAST-CARCINOMA. Journal of Clinical Pathology, 46 (10), 922-925. doi: 10.1136/jcp.46.10.922
Mucin Inclusions in Urothelial Carcinomas
Samaratunga, H, Hohn, BG, Walsh, MD, Gardiner, RA, Devine, PL and McGuckin, MA (1993). Mucin Inclusions in Urothelial Carcinomas. Human Pathology, 24 (8), 929-930. doi: 10.1016/0046-8177(93)90147-9
Monoclonal antibodies reacting with the MUC2 mucin core protein
Devine, P. L., McGuckin, M. A., Birrell, G. W., Whitehead, R. H., Sachdev, G. P., Shield, P. and Ward, B. G. (1993). Monoclonal antibodies reacting with the MUC2 mucin core protein. British Journal of Cancer, 67 (6), 1182-1188. doi: 10.1038/bjc.1993.223
Circulating tumour-associated mucin concentrations, determined by the CASA assay, in healthy women
McGuckin, MA, Ramm, LE, Joy, GJ, Devine, PL and Ward, BG (1993). Circulating tumour-associated mucin concentrations, determined by the CASA assay, in healthy women. Clinica Chimica Acta, 214 (2), 139-151. doi: 10.1016/0009-8981(93)90106-E
Devine P.L., McGuckin M.A., Ramm L.E., Ward B.G., Pee D. and Long S. (1993). Serum mucin antigens CASA and MSA in tumors of the breast, ovary, lung, pancreas, bladder, colon, and prostate: A blind trial with 420 patients. Cancer, 72 (6), 2007-2015. doi: 10.1002/1097-0142(19930915)72:6<2007::AID-CNCR2820720636>3.0.CO;2-U
Ward, BG, McGuckin, MA, Ramm, LE, Coglan, M, Sanderson, B, Tripcony, L and Free, KE (1993). The Management of Ovarian-Carcinoma Is Improved by the Use of Cancer-Associated Serum Antigen and Ca-125 Assays. Cancer, 71 (2), 430-438. doi: 10.1002/1097-0142(19930115)71:2<430::AID-CNCR2820710225>3.0.CO;2-S
Devine, PL, McGuckin, MA, Ramm, LE, Harada, H and Ward, BG (1993). The Use of Mucin-Specific Monoclonal-Antibodies and Lectins in the Detection of Tumor-Associated Serum Markers in Gynecological Cancer. Cancer Biochemistry Biophysics, 13 (4), 221-238.
Comparative-Study of Mammography and Mammary Serum Antigen Estimation for Breast-Cancer Screening
Ward, BG, Joy, GJ, Ramm, LE, Baker, CA and McGuckin, MA (1992). Comparative-Study of Mammography and Mammary Serum Antigen Estimation for Breast-Cancer Screening. Medical Journal of Australia, 157 (3), 161-164. doi: 10.5694/j.1326-5377.1992.tb137077.x
Circulating Mucins as Tumor-Markers in Ovarian-Cancer
Devine, PL, McGuckin, MA and Ward, BG (1992). Circulating Mucins as Tumor-Markers in Ovarian-Cancer. Anticancer Research, 12 (3), 709-717.
MCGUCKIN, MA, RAMM, LE, JOY, GJ, FREE, KE and WARD, BG (1992). PREOPERATIVE DISCRIMINATION BETWEEN OVARIAN-CARCINOMA, NON-OVARIAN GYNECOLOGICAL MALIGNANCY AND BENIGN ADNEXAL MASSES USING SERUM LEVELS OF CA125 AND THE POLYMORPHIC EPITHELIAL MUCIN ANTIGENS CASA, OSA AND MSA. International Journal of Gynecological Cancer, 2 (3), 119-128. doi: 10.1046/j.1525-1438.1992.02030119.x
Effects of photoperiod on the reproductive physiology of male flying foxes, pteropus poliocephalus
McGuckin M.A. and Blackshaw A.W. (1992). Effects of photoperiod on the reproductive physiology of male flying foxes, pteropus poliocephalus. Reproduction, Fertility and Development, 4 (1), 43-53. doi: 10.1071/RD9920043
EXPRESSION OF TUMOR-MARKERS CA125, CASA AND OSA IN MINIMAL MILD ENDOMETRIOSIS
WARD, BG, MCGUCKIN, MA, RAMM, L and FORBES, KL (1991). EXPRESSION OF TUMOR-MARKERS CA125, CASA AND OSA IN MINIMAL MILD ENDOMETRIOSIS. Australian & New Zealand Journal of Obstetrics & Gynaecology, 31 (3), 273-275. doi: 10.1111/j.1479-828X.1991.tb02797.x
MCGUCKIN, MA, WRIGHT, G and WARD, BG (1991). EXPRESSION OF A POLYMORPHIC EPITHELIAL MUCIN ANTIGEN DEFINED BY THE MONOCLONAL-ANTIBODY BC2 IN OVARIAN-CARCINOMA - USE OF THE BC2 ANTIBODY FOR THE DETECTION OF MICROMETASTASES. American Journal of Clinical Pathology, 96 (1), 46-52.
MCGUCKIN, MA and BLACKSHAW, AW (1991). MATING-ASSOCIATED PEAK IN PLASMA TESTOSTERONE CONCENTRATION IN WILD MALE GRAY-HEADED FLYING FOXES (PTEROPUS-POLIOCEPHALUS). Journal of Reproduction and Fertility, 92 (2), 347-352.
McGuckin, MA and Blackshaw, AW (1991). Seasonal-Changes in Testicular Size, Plasma Testosterone Concentration and Body-Weight in Captive Flying Foxes (Pteropus-Poliocephalus and P-Scapulatus). Journal of Reproduction and Fertility, 92 (2), 339-346. doi: 10.1530/jrf.0.0920339
McGuckin M.A., Wright G. and Ward B.G. (1991). Expression of a polymorphic epithelial mucin antigen defined by the monoclonal antibody BC2 in ovarian carcinoma: Use of the BC2 antibody for the detection of micrometastases. American Journal of Clinical Pathology, 96 (1), 46-52. doi: 10.1093/ajcp/96.1.46
Expression of tumour markers CA125, CASA and OSA in minimal/mild endometriosis
Ward B.G., McGuckin M.A., Ramm L. and Forbes K.L. (1991). Expression of tumour markers CA125, CASA and OSA in minimal/mild endometriosis. Australian and New Zealand Journal of Obstetrics and Gynaecology, 31 (3), 273-275.
McGuckin M.A. and Blackshaw A.W. (1991). Mating-associated peak in plasma testosterone concentration in wild male grey-headed flying foxes (Pteropus poliocephalus). Journal of Reproduction and Fertility, 92 (2), 347-352. doi: 10.1530/jrf.0.0920347
McGuckin, MA, Wright, RG, McKenzie, Ifc and Ward, BG (1990). Demonstration of 2 Ovarian Tumor Associated Antigens in Primary and Metastatic Breast, Gastric, and Colonic Tumors. American Journal of Clinical Pathology, 94 (2), 137-141. doi: 10.1093/ajcp/94.2.137
McGuckin M.A., Owens M., Wright R.G., McKenzie I.F.C. and Ward B.G. (1990). Demonstration of seven tumor-associated antigens in epithelial ovarian cancer by immunohistochemistry using monoclonal antibodies. Journal of Tumor Marker Oncology, 5 (1), 87-94.
McGuckin, Michael A., Layton, Guy T., Bailey, Mark J., Hurst, Terry, Khoo, Soo Keat and Ward, Bruce G. (1990). Evaluation of two new assays for tumor-associated antigens, CASA and OSA, found in the serum of patients with epithelial ovarian carcinoma-Comparison with CA125. Gynecologic Oncology, 37 (2), 165-171. doi: 10.1016/0090-8258(90)90328-I
Expression of Multiple Tumor-Markers in Serum From Patients with Ovarian-Carcinoma and Healthy Women
Ward, BG, McGuckin, MA, Hurst, TG and Khoo, SK (1989). Expression of Multiple Tumor-Markers in Serum From Patients with Ovarian-Carcinoma and Healthy Women. Australian & New Zealand Journal of Obstetrics & Gynaecology, 29 (3), 340-345. doi: 10.1111/j.1479-828X.1989.tb01759.x
Cycle of the Seminiferous Epithelium in the Gray-Headed Fruit Bat, Pteropus-Poliocephalus
McGuckin, MA and Blackshaw, AW (1987). Cycle of the Seminiferous Epithelium in the Gray-Headed Fruit Bat, Pteropus-Poliocephalus. Australian Journal of Biological Sciences, 40 (2), 203-210. doi: 10.1071/BI9870203
MCGUCKIN, MA and BLACKSHAW, AW (1987). SEASONAL-CHANGES IN SPERMATOGENESIS (INCLUDING GERM-CELL DEGENERATION) AND PLASMA TESTOSTERONE CONCENTRATION IN THE GRAY-HEADED FRUIT BAT, PTEROPUS-POLIOCEPHALUS. Australian Journal of Biological Sciences, 40 (2), 211-220.
Mc Guckin M.A. and Blackshaw A.W. (1987). Seasonal changes in spermatogenesis (including germ cell degeneration) and plasma testosterone concentration in the grey-headed fruit bat, pteropus poliocephalus. Australian Journal of Biological Sciences, 40 (2), 211-220. doi: 10.1071/BI9870211
Rahman, M. A., Moniruzzaman, M., Wang, R., Harding, A., Wiid, P., Sajiir, H., Yong, K. Y., Sheng, Y., Mueller, A., Symon, H., Varelias, A., McGuckin, M., Phipps, S. and Hasnain, S. (2022). A novel role for interleukin-22 signaling in modulating mucosal epithelial cell antigen presentation machinery to control disease. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW), Sydney, NSW, Australia, 9–11 September 2022. Richmond, VIC, Australia: John Wiley & Sons.
Prins, John B., Sajiir, Haressh, Keshvari, Sahar, Wong, Kuan Yau, Lockett, Jack, McGuckin, Michael and Hasnain, Sumaira Z. (2022). Targeted IL-22 Improves Glucose Tolerance and Reduces Hepatic Steatosis and Hepatic Fibrosis in Murine Models of Diabetes and Liver Disease. American Diabetes Association 82nd Scientific Sessions, New Orleans, LA United States, 3-7 June 2021. Arlington, VA United States: American Diabetes Association. doi: 10.2337/db22-119-lb
Sajiir, Haressh, Wong, Kuanyau, Mueller, Alexander, Keshvari, Sahar, Wang, Ran, Macdonald, Graeme A., Prins, John, Mcguckin, Michael and Hasnain, Sumaira Z. (2022). Building a case for liver and pancreas targeted interleukin-22 therapy for use in non-alcoholic fatty liver disease. Digestive Disease Week 2022, San Diego, CA United States, 21-24 May 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(22)60035-0
Sheng, Yong H., Giri, Rabina, Davies, Julie, Schreiber, Veronika, Alabbas, Saleh Y., He, Yaowu, Wu, Andy, Hooper, John, Oancea, Iulia, Kijanka, Gregor, Hasnain, Sumaira Z., McGuckin, Michael, Florin, Timothy H. and Begun, Jakob (2020). Thioguanine inhibits colorectal tumorigenesis via β-catenin signalling in intestinal epithelial cells independently of immunosuppression or autophagy. DDW 2020, Online, 2-5 May 2020. Philadelphia, PA United States: Elsevier . doi: 10.1016/s0016-5085(20)30856-8
Airways mucus pathogenesis in patients with non-cystic fibrosis bronchiectasis
Ramsey, Kathryn, Radicioni, Giorgia, Hill, David, Ehre, Camille, Button, Brian, Alexis, Neil E., Knowles, Michael, Donaldson, Scott, Kesimer, Mehmet, Mcguckin, Michael and Boucher, Richard (2018). Airways mucus pathogenesis in patients with non-cystic fibrosis bronchiectasis. 28th International Congress of the European-Respiratory-Society (ERS), Paris France, Sep 15-19, 2018. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2018.PA5049
Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation
Wang, R., Giri, R., Moniruzzaman, M., Tong, H., Wong, K. Y., Begun, J., McGuckin, M. A. and Hasnain, S. Z. (2018). Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “Gut Matters”, Brisbane, QLD, Australia, 8-10 September 2018. Richmond, VIC, Australia: John Wiley & Sons.
Interleukin-22: A potential therapy to control intestinal inflammation
Moniruzzaman, M., Wang, R., Wong, K. Y., Tong, H., McGuckin, M. A. and Hasnain, S. Z. (2018). Interleukin-22: A potential therapy to control intestinal inflammation. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “Gut Matters”, Brisbane, QLD, Australia, 8-10 September 2018. Richmond, VIC, Australia: John Wiley & Sons.
Lineburg, Katie E., Le Texier, Laetitia, Melino, Michelle, Wang, Ran, Clouston, Andrew, Blazar, Bruce R., McGuckin, Michael A., Villadangos, Jose A., Mintern, Justine D. and MacDonald, Kelli P. A. (2018). Ubiquitin Ligase MARCH8 attenuates Graft versus Host Disease via Regulation of Gut Epithelial Cell Surface MHC II Expression. 27th International Congress of the Transplantation-Society (TTS), Madrid, Spain, 30 June - 5 July 2018. Philadelphia, PA, United States: Lippincott Williams & Wilkins. doi: 10.1097/01.tp.0000543013.84163.3a
Radicioni, G., Ramsey, K. A., McGuckin, M., Knowles, M. R., Boucher, R. C. and Kesimer, M. (2018). Airways Mucus Proteome Reveals Unique and Common Pathways in Non-CF Bronchiectasis and Primary Ciliary Dyskinesia. International Conference of the American-Thoracic-Society, San Diego Ca, May 18-23, 2018. NEW YORK: AMER THORACIC SOC.
Effect of Differential Exercise Intensities on Interleukin-22 in Metabolic Syndrome
Ramos, Joyce S., Dalleck, Lance C., Mielke, Gregore I., Keating, Shelley E., McGuckin, Michael, Murray, Lydia S., Hasnain, Sumaira, Fassett, Robert G. and Coombes, Jeff S. (2017). Effect of Differential Exercise Intensities on Interleukin-22 in Metabolic Syndrome. Annual Meeting of the American-College-of-Sports-Medicine (ACSM), Denver Co, May 30-Jun 03, 2017. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1249/01.mss.0000519264.21081.61
Burr, L. D., Rogers, G. B., Chen, A. C., Taylor, S., Bowler, S., Serisier, D. and McGuckin, M. (2016). Erythromycin Inhibits Expression Of P. AerugINOSa Quorum Sensing Genes In The Airways Of Non-Cf Bronchiectasis Subjects Recruited To The Bless Randomised Controlled Trial. International Conference of the American-Thoracic-Society (ATS), San Francisco Ca, May 13-18, 2016. New York, NY, United States: American Thoracic Society.
High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22
Gulhane, M., Lourie, R., Tong, H., Kang, A., Schreiber, V., Magor, G., Denman, S., Begun, J., Florin, T., Perkins, A., O Cuiv, P., Mcguckin, M. and Hasnain, S. Z. (2016). High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21–26 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200
Sheng, Yong H., He, Yaowu, Hasnain, Sumaira Z., Wang, Ran, Tong, Hui, Clarke, Daniel T., Lourie, Rohan, Oancea, Lulia, Wong, Kuanyau, Lumley, John W., Florin, Timothy H., Sutton, Philip, Hooper, John. D., Mcmillan, Nigel A. and Mcguckin, Michael A. (2016). MUC13 protects colorectal cancer cells from death by activating the NF-Kb pathway and is a potential therapeutic target. AACR 107th Annual Meeting on Bioinformatics and Systems Biology, New Orleans, Los Angeles, 16-20 April 2016 . Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2016-3564
Hasnain, S. Z., Taylor, S., Wang, R., Chen, A., Oancea, I, Das, I, Tong, H., Florin, T., Serisier, D., Coulson, B., Mcauley, J., Lourie, R., Phipps, S. and Mcguckin, M. (2016). Unravelling a novel mechanism by which cytokines induce ER stress to halt viral protein synthesis in mucosal epithelial cells. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/eji.201670200
IL-22-mediated suppression of islet inflammation
McGuckin, Mike, Hasnain, Sumaira Z., Borg, Danielle J., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathon P., Forbes, Josephine M. and Prins, John B. (2015). IL-22-mediated suppression of islet inflammation. IPITA/IXA/CTS Joint Congress, Melbourne Australia, Nov 15-19, 2015. HOBOKEN: LIPPINCOTT WILLIAMS & WILKINS.
Collagen protease levels vary with airway microbiota composition and lung function in bronchiectasis
Taylor, S., Rogers, G., Chen, A., Burr, L., McGuckin, M. and Serisier, D. (2015). Collagen protease levels vary with airway microbiota composition and lung function in bronchiectasis. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, Gold Coast, Australia, 27 March – 1 April 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12495_14
High fat diet and the colonic mucus barrier: implications for obesity and inflammatory bowel disease
Gulhane, M., Murray, L., Wang, R., Tong, H., Mcguckin, M. and Hasnain, S. (2015). High fat diet and the colonic mucus barrier: implications for obesity and inflammatory bowel disease. Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13094
IL-22-MEDIATED SUPPRESSION OF ISLET INFLAMMATION
McGuckin, Mike, Hasnain, Sumaira Z., Borg, Danielle J., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathon P., Forbes, Josephine M. and Prins, John B. (2015). IL-22-MEDIATED SUPPRESSION OF ISLET INFLAMMATION. Joint Congress of the International-Pancreas-and-Islet-Transplantation-Association, International-Xenotransplantation-Association and Cell-Transplant-Society, Melbourne Australia, Nov 15-19, 2015. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
Burr, L., Rogers, G., Taylor, S., McGuckin, M. and Serisier, D. (2015). Sub inhibitory erythromycin reduces the expression of key P. aeruginosa virulence determinants in non-CF bronchiectasis subjects. Thoracic Society Australia New Zealand Australian New Zealand Society Respiratory Science Annual Scientific Meeting 2015, Queensland Australia, Mar 27-Apr 01, 2015. Hoboken, NJ United States: Wiley-Blackwell.
Burr, L., Rogers, G., Taylor, S., McGuckin, M. and Serisier, D. (2015). Sub inhibitory erythromycin reduces the expression of key P. aeruginosa virulence determinants in vitro. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, Gold Coast, Australia, 27 March – 1 April 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12495_14
Chen, A., Martin, M., Lourie, R., Burr, L., Hasnain, S., Bowler, S., Mcguckin, M. and Serisier, D. (2014). Clinical Benefits of Long-Term, Low-Dose Erythromycin in Bronchiectasis Are Not Due to Modulation of Sputum Mucin Content. Annual Scientific Meeting of the Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science 2014, Adelaide, SA Australia, 4-9 April 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12263_6
Wang, Ran, Hasnain, Sumaira Z., Tong, Hui, Lourie, Rohan, Florin, Timothy H. and McGuckin, Michael A. (2014). Direct Adverse Effects of IL-23 on Epithelial Cells Underline Greater Efficacy of Neutralizing IL-23 in Suppressing Murine Colitis. 55th Annual Meeting of the Society for Surgery of the Alimentary Tract (SSAT) / Digestive Disease Week (DDW), Chicago, Il, United States, May 03-06, 2014. Maryland Heights, MO, United States: W.B. Saunders Co.. doi: 10.1016/S0016-5085(14)62987-5
Chen, A., Lourie, R., Martin, M., Burr, L., Hasnain, S., Fantino, E., Bowler, S., Mcguckin, M. and Serisier, D. (2014). Human Neutrophil Elastase Activity and Matrix Metalloproteinase Activity Are Markers of Disease Severity in Non-Cf Bronchiectasis. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2014 Annual Scientific Meetings, Adelaide Australia, 4-9 April 2014. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12263_6
Lourie, Rohan, Hasnain, Sumaira Z., McGuckin, Michael A. and Florin, Timothy H. (2014). IL-22 May Maintain Colonic Mucosal Barrier Function by Overriding ROS-Induced ER Stress and Chemokine Production in Colonic Epithelial Cells. Digestive Disease Week 2014, Chicago, Illinois, 3-6 May 2014. Maryland Heights, MO, United States: W.B. Saunders Co..
IL-23 and IL-24 Upregulate Pro-Inflammatory Chemokine Genes in Colonic Epithelial Cells
Lourie, R., Hasnain, S. Z., McGuckin, M. A. and Florin, T. H. (2014). IL-23 and IL-24 Upregulate Pro-Inflammatory Chemokine Genes in Colonic Epithelial Cells. 103rd Annual Meeting of the United States and Canadian Academy of Pathology (USCAP), San Diego, California, 1-7 March 2014. London, United Kingdom: Nature Publishing Group.
Shah, A., Talley, N. J., Walker, M., Koloski, N., Shanahan, E. R., Morrison, M., Burger, D., Andrews, J. M., Mcguckin, M., Jones, M. and Holtmann, G. (2014). Is geographic variability of incidence and prevalence of Crohn's Disease linked to Helicobacter pylori? An ecologic study. Australian Gastroenterology Week 2014, Broadbeach, QLD Australia, 22-24 October 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736_6
Burr, L. D., Rogers, G., Chen, A., McGuckin, M. and Serisier, D. J. (2014). Peroxisome Proliferator Activated Receptor. Gene Expression In The Airways Of Non Cystic Fibrosis Bronchiectasis Subjects Is Lower Than Healthy Controls And Inversely Correlated To Total Pseudomonas AerugINOSa Bacterial Load At Baseline Entry Into A Clinical Trial. NEW YORK: AMER THORACIC SOC.
Winkler, Ingrid G., Barbier, Valerie, Nutt, Heather L., Hasnain, Sumaira Z., Levesque, Jean-Pierre, Magnani, John L. and McGuckin, Michael A. (2013). Administration Of E-Selectin Antagonist GMI-1271 Improves Survival After High-Dose Chemotherapy By Alleviating Mucositis and Accelerating Neutrophil Recovery. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans La, Dec 07-10, 2013. WASHINGTON: AMER SOC HEMATOLOGY.
Rehaume, Linda, Mondot, Stanislas, Aguirre de Cárcer, D., Velasco, Jared, Benham, Helen, Hasnain, Sumaira, Bowman, Jaclyn, Ruutu, Merja, Hansbro, Philip, McGuckin, Michael, Morrison, Mark and Thomas, Ranjeny (2013). Host Genetic Background Disrupts The Relationship Between Microbiota and Gut Mucosal Tolerance Leading To Spondyloarthritis and Ileitis After a Dectin-1 Trigger.. 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego Ca, 25-30 October 2013. Hoboken, NJ United States: John Wiley and Sons Inc.. doi: 10.1002/art.38216
Rehaume, L., Mondot, S., Aguirre de Cárcer, D., Velasco, J., Benham, H., Hasnain, S., Ruutu, M., McGuckin, M. and Morrison, M. (2013). Incidence and Severity of Spondyloarthritis and Ileitis Are Determined by Interaction Between the Microbiota and Genetic Susceptibility in Beta-Glucan-Treated Skg Mice. 54th Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with the Rheumatology Health Professionals Association, Perth, WA Australia, 18 -22 May 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/imj.12139
Intestinal Endoplasmic Reticulum Stress is Modulated by Inflammatory Cytokines
Hasnain, Sumaira Z., Tauro, Sharyn, Jeffery, Penny, Das, Indrajit, Tran, Thu V., Florin, Timothy H. and McGuckin, Michael A. (2012). Intestinal Endoplasmic Reticulum Stress is Modulated by Inflammatory Cytokines. Digestive Disease Week (DDW), San Diego Ca, May 19-22, 2012. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
Thomas, Ranjeny, Rehaume, Linda, Aguirre de Cárcer, Daniel, Mondot, Stan, Velasco, Jared, Benham, Helen, Ruutu, Merja, Morrison, Mark and McGuckin, Michael (2012). Incidence and severity of spondyloarthritis and Crohn's Ileitis are determined by interaction between the microbiota and genetic susceptibility in beta-glucan-treated SKG mice. Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, 9-14 November 2012. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/art.37735
Benham, H., Rehaume, L., Ruutu, M., Velasco, J., Strutton, G., McGuckin, M. and Thomas, R. (2012). Protective and Pathogenic Effects of the Il-23 Family of Cytokines in Spondyloarthropathy in Skg Mice. 53rd Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with Rheumatology Health Professionals, Canberra ACT, Australia, 12-15 May 2012. Richmond Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1445-5994.2012.02759.x
Benham, Helen, Rehaume, Linda, Ruutu, Merja, Velasco, Jared, Kikly, Kristine, Strutton, Geoffrey, McGuckin, Michael and Thomas, Ranjeny (2012). Protective and pathogenic effects of the IL-23 family of cytokines in spondyloarthropathy in SKG mice. Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, 9-14 November 2012. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/art.37735
Rehaume, L., Aguirre de Cárcer, D., Velasco, J., Benham, H., Ruutu, M., Mondot, S., Morrison, M. and McGuckin, M. (2012). The role of intestinal microbiota in the development of spondyloarthritis in fungal beta-glucan-treated autoimmune prone skg mice. 53rd Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with Rheumatology Health Professionals, Canberra ACT, Australia, 12-15 May 2012. Richmond Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1445-5994.2012.02759.x
Intestinal secretory cell ER stress and inflammation
McGuckin, Michael A., Eri, Rajaraman D., Das, Indrajit, Lourie, Rohan and Florin, Timothy H. (2011). Intestinal secretory cell ER stress and inflammation. London, United Kingdom: Portland Press. doi: 10.1042/BST0391081
Microbiome shifts with 6-thioguanine provide insights about IBD and its treatment
De Carcer, D. Aguirre, Oancea, I., Das, I., Mcguckin, M., Duley, J., Morrison, M. and Florin, T. (2011). Microbiome shifts with 6-thioguanine provide insights about IBD and its treatment. Australian Gastroenterology Week 2011, South Bank, QLD, Australia, 12–15 September 2011. MALDEN: WILEY-BLACKWELL. doi: 10.1111/j.1440-1746.2011.06820.x
Mubarak, V, Bowler, S, Serisier, D and Mcguckin, M (2011). Pepsin as a Marker of Aspiration in the Exhaled Breath Condensate of Patients with Cystic Fibrosis: a Pilot Study. Unknown, unknown, unknown. MALDEN: WILEY-BLACKWELL.
Sheng, YH, Lourie, R, Linden, SK, Jeffery, P, Roche, DK, Tran, TV, Png, CW, Waterhouse, N, Sutton, P, Florin, TH and McGuckin, MA (2011). The MUC13 Cell Surface Mucin Protects Against Intestinal Inflammation by Inhibiting Epithelial Cell Apoptosis. Conference on Digestive Disease Week 2011, Chicago Il, May 07-10, 2011. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
Ruutu, Merja, Velasco, Jared, Aguirre, Daniel, Benham, Helen, Morrison, Mark, McGuckin, Michael and Thomas, Ranjeny (2011). The Role of Gut Microflora and Autoreactive CD4+T Cells in the Development of Spondyloarthritis and Inflammatory Bowel Disease in Beta-Glucan-Treated SKG Mice. 75th Annual Scientific Meeting of the American College of Rheumatology/46th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, Chicago, IL, United States, 4-9 November 2011. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/art.33310
Walsh, M. D., Cummings, M. C., Buchanan, D. D., Arnold, S., Mckeone, D. M., Walters, R., Hopper, J. L., Jenkins, M. A., Mcguckin, M. A. and Young, J. (2010). Lynch syndrome-associated breast cancers: clinicopathological characteristics of a case series from the colon CFR. MALDEN: WILEY-BLACKWELL PUBLISHING, INC.
Rosty, Christophe, Walsh, Michael, Cummings, Margaret, Buchanan, Daniel, Arnold, Sven, McKeone, Diane, Walters, Rhiannon, Hopper, John, Jenkins, Mark, Spurdle, Amanda, McGuckin, Michael, Lakhani, Sunil and Young, Joanne (2010). Lynch syndrome-associated breast cancers: clinicopathological characteristics of a case series from the Colon CFR. AACR 101st Annual Meeting 2010, Washington, DC, United States, 17-21 April 2010. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM10-32
Dexamethasone ameliorates intestinal epithelial cell ER stress and ER stress induced colitis
McGuckin, M. A., Das, I., Png, C. W., Tran, T., Eri, R., Lourie, R., Adams, R., Crane, D. and Florin, T. H. (2010). Dexamethasone ameliorates intestinal epithelial cell ER stress and ER stress induced colitis. Australian Gastroenterology Week 2010, Broadbeach, Qld., Australia, 20-23 October 2010. Richmond, Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2010.06454.x
Effect of Loss of Tolerance in a TH17 Mediated Mouse Model of ER Stress Induced Colitis
Tauro, Sharyn B., Eri, Rajaraman D., Jeffery, Penny, Adams, Rachel J., Tran, Thu V., Roche, Deborah, Florin, Timothy H. and McGuckin, Michael A. (2009). Effect of Loss of Tolerance in a TH17 Mediated Mouse Model of ER Stress Induced Colitis. Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association, Chicago Il, May 30-Jun 04, 2009. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
KCNN4 Gene Variant Is Associated with Ileal Crohn's Disease
Simms, Lisa A., Doecke, James D., Fowler, Elizabeth V., Zhao, Zhen Zhen, McGuckin, Michael A., Huang, Ning, Hayward, Nicholas K., Webb, Penelope M., Whiteman, David, Cavanaugh, Juleen, McCallum, Ruth K., Merriman, Tony R., Florin, Timothy H., Barclay, Murray L., Gearry, Richard B., Roberts, Rebecca L., Montgomery, Grant W. and Radford-Smith, Graham L. (2009). KCNN4 Gene Variant Is Associated with Ileal Crohn's Disease. Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association, Chicago Il, May 30-Jun 04, 2009. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
The effect of thiopurine on leukocytes in a C57BL/6 mouse model
Oancea, Iulia, Eri, Rajaraman D., McGuckin, Michael A., Duley, John A. and Florin, Timothy H. (2009). The effect of thiopurine on leukocytes in a C57BL/6 mouse model. *, *, *. Maryland Heights, MO, United States: W.B. Saunders Co..
DNA mismatch repair deficiency in breast cancers arising in breast/colon families
Walsh, M., Cummings, M., Buchanan, D., Arnold, S., McKeone, D., Walters, R., Jass, J., Hopper, J., Jenkins, M., Spurdle, A., McGuckin, M. and Young, J. (2008). DNA mismatch repair deficiency in breast cancers arising in breast/colon families. 27th International Congress of the International-Academy-of-Pathology, Athens Greece, Oct 12-17, 2008. MALDEN: WILEY-BLACKWELL PUBLISHING, INC.
Inhibition of endoplasmic stress by dexamethasone: a novel action relevant to ulcerative colitis?
Das, I., Eri, R., Ping, C. W., Tran, T., Adams, R., McGuckin, M. A. and Florin, T. H. (2008). Inhibition of endoplasmic stress by dexamethasone: a novel action relevant to ulcerative colitis?. MALDEN: WILEY-BLACKWELL PUBLISHING, INC.
Muc1 limits H-pylori infection fly acting as a releasable decoy
Linden, Sara K., Miles, Kim M., Florin, Timothy H., Dubois, Andre and McGuckin, Michael A. (2008). Muc1 limits H-pylori infection fly acting as a releasable decoy. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
Aberrant mucin assembly links endoplasmic reticulum stress with ulcerative colitis
Mcguckin, Michael A., Eri, Rajaraman, Heazlewood, Chad K., Cook, Matthew C., Taupin, Doug R., Thornton, David J., Png, Chin Wen, Crockford, Tanya L., Cornall, Richard J., Kato, Masato, Nelms, Keats A., Hong, Nancy A., Goodnow, Christopher C. and Florin, Timothy H. (2007). Aberrant mucin assembly links endoplasmic reticulum stress with ulcerative colitis. Digestive Disease Weeking Meeting/ASGE Postgraduate Course Meeting, Washington Dc, May 19-24, 2007. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
Antibodies to complex microbial mixtures are a better diagnostic for Crohn's disease
Adams, Rachel J., Heazlewood, Sharise P., O'brien, Mark, Mcguckin, Michael A. and Florin, Timothy H. (2007). Antibodies to complex microbial mixtures are a better diagnostic for Crohn's disease. Digestive Disease Weeking Meeting/ASGE Postgraduate Course Meeting, Washington Dc, May 19-24, 2007. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
Eri, Rajaraman D., Florin, Timothy H., Price, Gareth, Heazlewood, Chad K., Cook, Matthew C., Goodnow, Christopher C. and Mcguckin, Michael A. (2007). Endoplasmic reticulum stress in goblet cells leads directly to intestinal inflammation with similarities to ulcerative colitis. Digestive Disease Weeking Meeting/ASGE Postgraduate Course Meeting, Washington, DC, United States, 19-24 May 2007. Philadelphia, PA, United States: Elsevier .
Effects of human mucin MUC2 on the expression of Campylobacter jejuni virulence factors
Mendz, G. L., Tu, Q. V. and McGuckin, M. A. (2007). Effects of human mucin MUC2 on the expression of Campylobacter jejuni virulence factors. OXFORD: BLACKWELL PUBLISHING.
Muc1 mucin limits both H-pylori colonisation of the gastric mucosa and associated gastritis
Sutton, P., Every, A. L., Skene, C. D., Linden, S., Harbour, S., Ferrero, R. and McGuckin, M. (2007). Muc1 mucin limits both H-pylori colonisation of the gastric mucosa and associated gastritis. OXFORD: BLACKWELL PUBLISHING.
Sulfate ions in mammalian physiology: Lessons from sulfate transporter null mice
Dawson, Paul Anthony, McGuckin, Michael A. and Markovich, Daniel (2007). Sulfate ions in mammalian physiology: Lessons from sulfate transporter null mice. Experimental Biology 2007 Annual Meeting, Washington, DC, United States, 28 April-2 May 2007. FEDERATION AMER SOC EXP BIOL.
The MUC13 cell surface mucin is highly expressed in human colorectal carcinomas
Walsh, Michael, Young, Joanne, Leggett, Barbara, Williams, Stephanie, Jeremy, Jass and McGuckin, Michael (2006). The MUC13 cell surface mucin is highly expressed in human colorectal carcinomas. 26th International Congress of the International-Academy-of-Pathology, Montreal Canada, Sep 16-21, 2006. NEW YORK: NATURE PUBLISHING GROUP.
The mucin MUC1 limits Helicobacter pylori colonisation of the gastric mucosa
Sutton, P, McAuley, J, Skene, C, Harbour, S and McGuckin, M (2005). The mucin MUC1 limits Helicobacter pylori colonisation of the gastric mucosa. 35th Annual SCientific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, Melbourne Australia, Nov 29-Dec 02, 2005. OXFORD: BLACKWELL PUBLISHING.
Real time per quantification of two mucolytic bacteria in IBD mucosa
Prig, CW, Heazlewood, SP, Story, D, Fowler, A, McGuckin, MA, Blackall, LL and Florin, TH (2005). Real time per quantification of two mucolytic bacteria in IBD mucosa. Annual Meeting of the American-Gastroenterological-Association/Digestive-Disease-Week, Chicago Il, May 14-19, 2005. PHILADELPHIA: W B SAUNDERS CO.
Spontaneous Apoptosis of Blood Dendritic Cells in Patients with Breast Cancer
Pinzon-Charry, Alberto, Maxwell, Tammy, McGuckin, Michael A., Schmidt, Chris, Furnival, Colin and Lopez, Jose A. (2005). Spontaneous Apoptosis of Blood Dendritic Cells in Patients with Breast Cancer. 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop, Melbourne, Australia, Conference dates. United States of America: John Wiley & Sons A/S. doi: 10.1111/j.1399-0039.2005.00523.x
Scott, JL, Halford, WK, McGuckin, MA, Ward, BG, Wetzig, NR and Pyke, C (2003). How can we disseminate psycho-oncology interventions to oncology and community settings? Results from a trial of a self-directed coping training program for women with cancer, and their closest support persons. CARLTON: AUSTRALIAN PSYCHOLOGICAL SOC.
Identification and characterisation of novel mucin genes
Williams, S., Antalis, T. M., Gotley, D. C. and McGuckin, M. A. (1999). Identification and characterisation of novel mucin genes. Australian Gastroenterology Week 1999, Brisbane Convention Centre, 4th - 8th October, 1999. Carlton, Vic: Blackwell Science Asia.
Identification and characterisation of novel mucin genes in a mucin cluster on chromosome 7Q22
Williams, S., Antalis, T. M., Gotley, D. C. and McGuckin, M. A. (1999). Identification and characterisation of novel mucin genes in a mucin cluster on chromosome 7Q22. Surgical Research Society of Australasia Annual Scientific Mg, Cairns International Hotel, 23-25 Sept, 1999. Qld: Surgical Res. Society of Australasia.
Biemer-Huttmann, A., Walsh, M. D., McGuckin, M. A., Ajioka, Y., Watanabe, H., Leggett, B. A. and Jass, J. R. (1999). Patterns of expression of MUC1, MUC2, MUC4 and MUC5AC mucins in hyperplastic polyps, serrated adenomas and traditional adenomas of the colorectum. Lorne, Vic., 11-14 Feb, 1999.
McGuckin, Michael Andrew (1989). Seasonal changes in the reproductive physiology of male flying-foxes (Pteropus spp.) in south east Queensland. PhD Thesis, School of Biomedical Sciences, The University of Queensland. doi: 10.14264/uql.2017.614
(2017–2020) United States Congressionally Directed Medical Research Programs - Peer Reviewed Medical Research Program
Pancreatic targeting of IL-22 therapy for diabetes
(2016–2018) NHMRC Development Grant
Elucidation of the Mechanism of IL-22-Mediated Suppression of Beta-Cell Stress in Diabetes
(2016–2017) NHMRC Project Grant
IL-22 as a Suppressor of Pancreatic Beta-Cell Stress and a Treatment for Diabetes
(2015–2019) NHMRC Project Grant
Engineering biomimetic lubrication with mucin
(2015–2017) ARC Discovery Projects
Pancreatic targeting of IL-22 therapy for diabetes
(2015) UQ Collaboration and Industry Engagement Fund - Seed Research Grant
NHMRC Research Fellowship (PRF): Understanding and Treating Inflammatory Disease
(2014–2017) NHMRC Research Fellowship
Cell Surface Mucins in Gastrointestinal Infection, Inflammation and Cancer Development
(2014–2016) NHMRC Project Grant
A new approach to tackling chemotherapy-induced mucositis
(2014–2015) Cancer Council Queensland
ER Stress as a Contributing Factor in Inflammatory Disease
(2013–2015) NHMRC Project Grant
(2013–2015) Murdoch Childrens Research Institute
NHMRC Research Fellowship (SRF B): Uncoupled Research Fellowship
(2013) NHMRC Research Fellowship
Targeting MUC13 to sensitise colorectal cancer cells to apoptosis
(2013) Cancer Council Queensland
Pathogenesis of a new mouse model of ankylosing spondylitis
(2012–2014) NHMRC Project Grant
Comprehensive cell imaging facility (ARC LIEF Grant administered by QUT)
(2011–2012) ARC LIEF Collaborating/Partner Organisation Contributions
(2008–2010) NHMRC Project Grant
The Role of Cell Surface Epithelial Mucin (MUC1) In Oropharyngeal Candidiasis
(2004) Australian Dental Research Fund Inc
Examining the role of IL-22 in metabolic syndrome
Doctor Philosophy — Associate Advisor
Other advisors:
(2017) Doctor Philosophy — Principal Advisor
Characterisation of immunopathology in non-CF bronchiectasis
(2015) Doctor Philosophy — Principal Advisor
Targeting IL-23/TH17 Axis in Suppressing Intestinal Inflammation
(2015) Doctor Philosophy — Principal Advisor
Other advisors:
Alterations in Mucin Expression in Common Malignancies
(2012) Doctor Philosophy — Principal Advisor
(2012) Doctor Philosophy — Principal Advisor
Biology of CA125 in ovarian cancer biology
(2009) Doctor Philosophy — Principal Advisor
Other advisors:
MUC1 IN INNATE AND ADAPTIVE IMMUNITY
(2005) Doctor Philosophy — Principal Advisor
INVESTIGATIONS OF HUMORAL AND CELLULAR IMMUNE RESPONSES DIRECTED AGAINST THE MUC1 EPITHELIAL MUCIN IN OVARIAN AND BREAST CARCINOMA
(2004) Doctor Philosophy — Principal Advisor
(2020) Doctor Philosophy — Associate Advisor
Other advisors:
Novel dietary factors in diabetic and non-diabetic kidney disease
(2020) Doctor Philosophy — Associate Advisor
Other advisors:
THERAPEUTIC MANIPULATION OF INTERLEUKIN-20 SUBFAMILY OF CYTOKINES IN ULCERATIVE COLITIS
(2020) Doctor Philosophy — Associate Advisor
Other advisors:
Mucin Structure and its Interaction with Dietary Fiber Polysaccharides
(2019) Doctor Philosophy — Associate Advisor
Other advisors:
Bio-responsive Nanoparticles for Site Specific Oral Drug Delivery
(2018) Doctor Philosophy — Associate Advisor
Other advisors:
Mucolytic Bacteria And The Mucosal Barrier In Inflammatory Bowel Diseases
(2009) Doctor Philosophy — Associate Advisor