Honorary Professor Michael McGuckin

Honorary Professor

Mater Research Institute-UQ
Faculty of Medicine


~~Mike McGuckin is a NHMRC Principal Research Fellow and is Deputy Director (Research) at at the Mater Research Institute – The University of Queensland within the new Translational Research Institute in Brisbane, where he leads the Inflammatory Disease Biology and Therapeutics Research Group. Mike is the author of over 130 scientific publications with his research currently focused on mucosal infection, chronic inflammation and cancer in the gastrointestinal tract, and has held 4 patents. He has particular interests in the role of secreted and cell surface mucin glycoproteins in cancer and in host defense from infection and inflammation. Mike also has a strong interest in the role of protein misfolding and ER stress in secretory cells in chronic inflammatory disease, including diabetes. He is heavily involved in national and international peer review, is on the Editorial Boards of four international journals, and has served as the lead member of the Academy of the Australian National Health and Medical Research Council for Gastroenterology. Mike chairs the Mater Research Committee, and serves on the Research Committees of the Gastroenterology Society of Australia, University of Queensland Faculty of Medicine and Biomedical Sciences and chairs the Facilitations Committee of the Translational Research Institute. In addition he is an elected Councilor for the International Society for Mucosal Immunology, and serves on the Board of Directors and Chairs the Medical and Scientific Advisory Committee for the Cancer Council Queensland, and is a member of the ANZ Trustees Limited Queensland Medical Research Grant Program Advisory Committee, and the Research and Development Committee for the Autism Collaborative Research Centre.

Research Interests

  • Cell surface mucin glycoproteins in infection, inflammation and cancer
  • Inflammatory bowel diseases
  • Non-cystic fibrosis bronchiectasis
  • Inflammation in the pathogenesis of type 2 diabetes
  • Protein misfolding and endoplasmic reticulum stress in chronic inflammatory diseases


  • PhD, The University of Queensland
  • MSc First Class Honours, The University of Queensland
  • Bachelor of Science, The University of Queensland


  • Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C. -H., Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Z. (2023). Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells. The Journal of Experimental Medicine, 220 (11) e20230106. doi: 10.1084/jem.20230106

  • McGuckin, Michael A., Davies, Julie M., Felgner, Pascal, Wong, Kuan Yau, Giri, Rabina, He, Yaowu, Moniruzzaman, Md., Kryza, Thomas, Sajiir, Haressh, Hooper, John D., Florin, Timothy H., Begun, Jakob, Oussalah, Abderrahim, Hasnain, Sumaira Z., Hensel, Michael and Sheng, Yong H. (2023). MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier. Cellular and Molecular Gastroenterology and Hepatology. doi: 10.1016/j.jcmgh.2023.08.011

  • Rahman, M. A., Moniruzzaman, M., Wang, R., Harding, A., Wiid, P., Sajiir, H., Yong, K. Y., Sheng, Y., Mueller, A., Symon, H., Varelias, A., McGuckin, M., Phipps, S. and Hasnain, S. (2022). A novel role for interleukin-22 signaling in modulating mucosal epithelial cell antigen presentation machinery to control disease. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW), Sydney, NSW, Australia, 9–11 September 2022. Richmond, VIC, Australia: John Wiley & Sons.

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  • Michael A. McGuckin and David J. Thornton eds. (2012). Mucins: methods and protocols. Methods in Molecular Biology, New York, NY, United States: Humana Press. doi: 10.1007/978-1-61779-513-8

Book Chapter

  • McGuckin, Michael A., Thornton, David J. and Whitsett, Jeffrey A. (2015). Mucins and mucus. Mucosal immunology: fourth edition. (pp. 231-250) edited by Jiri Mestecky, Warren Strober, Michael W. Russell, Brian L. Kelsall, Hilde Cheroutre and Bart N. Lambrecht. Kidlington, Oxford, United Kingdom: Elsevier. doi: 10.1016/B978-0-12-415847-4.00014-8

  • McGuckin, Michael A. (2013). Introduction to mucins in cancer. Mucins and Cancer. (pp. 6-18) edited by Joyce Taylor-Papadimitriou and Joy M Burchell. London: Future Medicine Limited. doi: 10.2217/fmeb2013.13.123

  • McGuckin, M. A., Ouellette, A. J. and Wu, G. D. (2013). Secreted effectors of the innate mucosal barrier. Principles of mucosal immunology. (pp. 37-51) edited by Phillip D. Smith, ThomasT. MacDonald and Richard S. Blumberg. London, United Kingdom: Taylor & Francis.

  • Harrop, Ceri A., Thornton, David J. and McGuckin, Michael A. (2012). Detecting, visualising, and quantifying mucins. Mucins: Methods and Protocols. (pp. 49-66) edited by Michael A. McGuckin and David J. Thornton. New York, NY, United States: Humana Press. doi: 10.1007/978-1-61779-513-8_3

  • Eri, Rajaraman, McGuckin, Michael A. and Wadley, Robert (2012). T cell transfer model of colitis: a great tool to assess the contribution of T cells in chronic intestinal inflammation. Leucocytes: methods and protocols. (pp. 261-275) New York, United States: Humana Press. doi: 10.1007/978-1-61779-527-5_19

  • Sheng, Yong H., Hasnain, Sumaira Z, Png, Chin Wen, McGuckin, Michael A. and Lindén, Sara K. (2012). Techniques for assessment of interactions of mucins with microbes and parasites in vitro and in vivo. Mucins: Methods and Protocols. (pp. 297-312) edited by Michael A. McGuckin and David J. Thornton. New York, NY, United States: Humana Press. doi: 10.1007/978-1-61779-513-8_18

  • Linden, Sara K. and McGuckin, Michael A. (2010). Microbes at the host surface. Current research, technology and education topics in applied microbiology and microbial biotechnology. (pp. 591-596) edited by A. Mendez-Vilas. Badajoz, Spain: Formatex Research Center.

Journal Article

Conference Publication

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Completed Supervision