Dr Mark Allenby

ARC DECRA Research Fellow

School of Chemical Engineering
Faculty of Engineering, Architecture and Information Technology

Overview

Dr Mark C Allenby is a Senior Lecturer in Biomedical Engineering (2021-ongoing) and an ARC DECRA Fellow (2022-2025) within UQ's School of Chemical Engineering. Mark is also an Advance Queensland Fellow (2019-2022) and Adjunct Senior Lecturer at QUT. Mark has principally supervised 5 PhDs and 2 MPhil/RAs, co-supervised 7 PhDs, and has been awarded over $2.8M of funding as chief investigator across 20 competitive funding rounds in 4 years. Mark received a PhD and MSc in chemical engineering from Imperial College London, UK and dual bachelors degrees in mathematics and chemistry from Pepperdine University, USA. Mark's background includes the engineering of dynamic stem cell bioreactors for tissue biomanufacturing, automated signal and image processing for tissue diagnostics, and model-based optimisation and control of 4D cell systems.

Research Interests: Mark leads the BioMimetic Systems Engineering (BMSE) Lab. In the BMSE Lab, we combine Tissue Engineering, Biomedical Image Analysis, and Computational Biology to study and solve biological and medical problems using biomimetic systems. Initially, we will focus on Systems of Blood, Blood Vessels, and Vascularised Tissue as these are essential building blocks for human and mammalian function. Our work aligns with chemical engineering fundamentals, cell therapy or medical device manufacturing, and clinical collaborators in haematology, vascular surgery, neurosurgery, and radiology. Our systems engineering approaches allow us to examine, model, engineer, optimise, control, scale, and automate dynamic systems of several entities such as multi-cellular tissues or cell-material and cell-fluid systems.

Academic Interests: Mark is the Convener of the Biomedical Engineering (BME) major at UQ. BME at UQ spans schools of Chemical Engineering (ChE), Electrical Engineering, and Mechanical Engineering, and engages with UQ's Faculty of Medicine and associated healthcare services. Mark is part of ChE teaching and scholarship committees, and Mark acts as the academic advisor for ChE-BME undergraduates. Mark is the creator and coordinator of BIOE3001: Quantitative Methods in Biomedical Engineering. Mark has previously taught courses in biomaterials, process modelling, and reaction engineering in ChE and BME departments at three universities in the UK and Australia. Part of Mark's role includes partnerships with UQ's BME undergraduate and research programs, interested bioindustry partners are encouraged to email Mark.

Our BMSE Lab is looking for excellent researchers at all levels. Postdoc candidates are welcome to contact us to explore fellowship applications. Interested PhD and MPhil candidates should consider applying with us to the UQ Annual HDR Scholarship Round.We are always recruiting masters and undergraduate thesis project students, a few of our projects are advertised on the EAIT Projects webpage. Interested candidates are encouraged to email Mark.

Research Interests

  • Tissue Engineering
    The field of tissue engineering aims to recreate tissue within the laboratory. We engineer synthetic platforms and culture cells to mimic or controllably grow complex and functional tissue at high density and scale. This artificial tissue may have future applications for therapeutics and grafts, testing and optimising interventions, and cellular agriculture. Topics: Biomaterial Fabrication, Bioreactor Engineering, Stem Cell & Tissue Culture.
  • Biomedical Image Analysis
    Imaging remains the gold standard technique to assess tissue quality and function. We capture microscopy and medical images and program algorithms and software to rapidly, automatically, and precisely diagnose our engineered tissue or patient tissue. This imaging data links our experiments to our computational models and to clinical data. Topics: Microscopy, MRI, CT, Segmentation, Statistical Shape Analyses, Co-Localisation, Motility & Fate Tracking
  • Computational Biology
    Predictive models of cell and tissue behaviour are necessary to optimise tissue manufacturing or guide clinical decision-making. Leveraging image analyses and culture experiments, we program multiscale mathematical or statistical models in single-cell, tissue-wide, or multi-tissue systems to link experiments to theory to practice. Topics: Cell Population Models (DE's), Single-Cell Models (Agent-Based), Tissue Biomechanics (FEA).

Qualifications

  • Doctor of Philosophy, The Imperial College of Science, Technology and Medicine

Publications

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Grants

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Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book Chapter

  • Paxton, Naomi C., Wong, Cynthia S., Desselle, Mathilde R., Allenby, Mark C. and Woodruff, Maria A. (2020). Bone morphogenetic protein–assisted bone regeneration and applications in biofabrication. Biomaterials for Organ and Tissue Regeneration. (pp. 363-391) edited by Nihal Engin Vrana, Helena Knopf-Marques and Julien Barthes. Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-08-102906-0.00016-7

  • Allenby, Mark C., Dos Santos, Susana Brito, Panoskaltsis, Nicki and Mantalaris, Athanasios (2019). Differentiation of human pluripotent stem cells for red blood cell production. Bioreactors for stem cell expansion and differentiation. (pp. 47-62) edited by Joaquim M. S. Cabral and Cláudia Lobato da Silva. Boca Raton, FL, United States: CRC Press. doi: 10.1201/9780429453144-3

Journal Article

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor