Emeritus Professor Maree Smith AC is Director, CIPDD, School of Biomedical Sciences, Faculty of Medicine, The University of Queensland.
In the 12 years prior to her current appointment, Professor Smith led a high-performing team in building the CIPDD and its commercial interface TetraQ, recognized as a unique, GLP-accredited drug development Centre in Australia. Professor Smith has considerable expertise in biomedical discovery/translation with specialist expertise in the pain field encompassing a portfolio of 15 rodent pain models that mimic individual human pain conditions. This portfolio of models conducted in a GLP-accredited facility is unique in Australia and rare internationally.
In the 15 years prior to establishing the CIPDD, Professor Maree Smith was a full-time academic in the School of Pharmacy. In brief, she joined the School of Pharmacy as a Lecturer in 1989 and was successively promoted through the academic ranks to Professor in 2004. Prior to that she undertook a PhD and early postdoctoral training in clinical pharmacology with specialist expertise in bioanalytical method development, bioanalysis of human plasma samples, drug metabolism and clinical pharmacokinetics. Her second postdoc was in the field of pain management and pain pharmacology.
In the years, 1990-2005, Maree Smith taught in the Drug Discovery stream of the 2nd, 3rd & 4th years of the undergraduate pharmacy program and she was instrumental in developing innovative courses for the final year of the undergraduate Pharmacy curriculum. More recently, she was instrumental in the development of a course for the M Biotech program at UQ entitled “Quality Systems in Biotechnology”. It was delivered successfully for the 6th time in 2015. Maree has successfully advised/co-advised to completion 28 PhD students, 2 Research Masters students and ~45 Honours students. She also served for 14 years as an external evaluator for the TGA.
Maree's Current Research Interests are as follows:
1. Subtle differences in the pathobiology of individual chronic pain conditions
2. Improving preclinical to clinical translation in novel analgesics development
3. Preclinical drug development of novel pain therapeutics
4. Preclinical drug development
Awards
2021 UQ Fellowship
2019 Companion of the Order of Australia (AC) in the Queen's Birthday Honours List
2018 Honorary Bragg Membership (The Royal Institution of Australia)
2016 Bowl of Hygeia Award (Pharmaceutical Society of Australia)
2016 Clunies Ross Knowledge Commercialisation Award (ATSE)
2015 Honoured to be included in inaugural list of Australia's top Innovators; viz Knowledge Nation 100
2015 Inaugural Inductee into the Life Sciences Queensland (LSQ) Hall of Fame
2015 Johnson and Johnson Innovaton AusBiotech Industry Excellen Award - Outstanding Leader category.
2015 Elected Fellow, Australian Academy of Health and Medical Sciences (AAHMS)
2015 Australian Pain Society Distinguished Member Award - For services to the promotion, treatment and science of pain management and lifelong contribution to the Australian Pain Society
2013 UQ Top 5 Inventor - Award by Thomson Reuters and UQ at inaugural Awards
2013 UQ Top 5 Innovator - Award by UniQuest Pty Ltd and UQ at inaugural Awards
2012 Queensland Life Sciences Industry Excellence Award jointly with Dr Jim Aylward
2011 Elected Fellow, Australian Academy of Technological Sciences (ATSE)
2009 Honorary Fellowship, Faculty of Pain Medicine, ANZCA (Australian and New Zealand College of Anaesthetists).
2008 WiT (Women in Technology): Biotech Outstanding Achievement Award
2002 Meritorious Mention for Sustained Excellence in Research Higher Degree Supervision
2001 Meritorious Mention for Sustained Excellence in Research Higher Degree Supervision
Maree is a leading researcher internationally in the pain field. Spinifex Pharmaceuticals was formed in 2005 to commercialize her angiotensin II type 2 (AT2) receptor antagonists technology for neuropathic pain and subsequently chronic inflammatory pain. Spinifex was acquired by Novartis in mid-2015 on the basis of successful early phase clinical trials in patients with post-herpetic neuralgia, a type of peripheral neuropathic pain that is often intractable.
Also, she has highly specialized expertise in the pain field encompassing a portfolio of 15 innovative rodent pain models that closely mimic individual human pain conditions. These models combined with the OECD GLP accreditation of the CIPDD facility means that these capabilities are unique in Australia and rare outside of large pharmaceutical companies internationally.
Book Chapter: Pain pharmacology and the pharmacological management of pain
Smith, Maree T. and Muralidharan, Arjun (2024). Pain pharmacology and the pharmacological management of pain. Pain: a textbook for health professionals. (pp. 225-248) edited by Hubert van Griensven and Jenny Strong. London, United Kingdom: Elsevier.
Journal Article: Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation
Shepherd, Andrew J., Rice, Andrew SC. and Smith, Maree T. (2023). Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation. Current Opinion in Pharmacology, 73 102415, 102415. doi: 10.1016/j.coph.2023.102415
Journal Article: In Vitro Assessment of the Metabolic Stability of Two Novel Endomorphin-2 Analogs, CYX-5 and CYX-6, in Rat Liver Microsomes
Imam, Mohammad Zafar, Ghassabian, Sussan, Kuo, Andy, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2023). In Vitro Assessment of the Metabolic Stability of Two Novel Endomorphin-2 Analogs, CYX-5 and CYX-6, in Rat Liver Microsomes. European Journal of Drug Metabolism and Pharmacokinetics, 48 (4), 463-466. doi: 10.1007/s13318-023-00828-6
(2023–2028) Therapeutic Innovation Australia Limited
(2023–2026) National Multiple Sclerosis Society-US
(2022–2026) NHMRC Synergy Grants
Discovery and Pharmacological Evaluation of Novel Analgesics for the Relief of Ross River Virus Induced Chronic Pain
Doctor Philosophy
Novel long-acting and orally delivered conotoxin-based peptides with both analgesic efficacy and disease modifying potential
Doctor Philosophy
Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model
Doctor Philosophy
Pathobiology of Neuropathic (nerve damage) Pain
Novel neuropathic pain therapeutics discovery
Painful Diabetic Neuropathy: Towards Improved Drug Treatments
Pain pharmacology and the pharmacological management of pain
Smith, Maree T. and Muralidharan, Arjun (2024). Pain pharmacology and the pharmacological management of pain. Pain: a textbook for health professionals. (pp. 225-248) edited by Hubert van Griensven and Jenny Strong. London, United Kingdom: Elsevier.
Side effects of central analgesic drugs
Imam, M. Z., Kuo, A. and Smith, M. T. (2022). Side effects of central analgesic drugs. Drug discovery and evaluation: safety and pharmacokinetic assays. (pp. 1-24) Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-030-73317-9_70-1
Smith, Maree and Hogg, Malcolm (2021). Are all opioids the same?. Opioid therapy for pain: a practical guide for clinicians. (pp. 105-118) edited by Kok Eng Khor, Alex Sia and Mary Cardosa. Singapore, Singapore: Red Cells Imprint, SingHealth Academy.
Pain pharmacology and the pharmacological management of pain
Smith, Maree T. and Muralidharan, Arjun (2014). Pain pharmacology and the pharmacological management of pain. Pain: a textbook for health professionals. (pp. 159-180) edited by Hubert van Griensven, Jenny Strong and Anita M. Unruh. London, United Kingdom: Elsevier.
Watson, C. Peter N., Gilron, Ian, Pollock, Bruce G., Lipman, Arthur G. and Smith, Maree T. (2013). Antidepressant analgesics. Wall and Melzack's textbook of pain. (pp. 465-496) edited by Stephen B. McMahon, Martin Koltzenberg, Irene Tracey and Dennis C. Turk. Philadelphia, United States: Elsevier Saunders.
Smith, Maree T. and Muralidharan, Arjun (2013). Pharmacogenetics of pain. eLS: Citable Reviews in the Life Sciences. (pp. 1-12) Chichester, U.K.: John Wiley & Sons. doi: 10.1002/047001590X
Smith, Maree T. and Goh, Wei H. (2011). Opioid analgesics. Pain management: Current issues and opinions. (pp. 287-306) edited by Gabor B. Racz and Carl E. Noe. Rijeka, Croatia: Intech Open Access.
Pain pharmacology and analgesia
Smith, Maree T. and South, Samantha M. (2008). Pain pharmacology and analgesia. Encyclopedia of Life Support Systems. (pp. 1-80) edited by H. Majewski. Oxford, U.K.: EOLSS Publishers.
Neurobiology of Pain: Identification of novel targets for new pain management medications
Smith, M. T. (2003). Neurobiology of Pain: Identification of novel targets for new pain management medications. Molecular Pathomechanisms and New Trends in Drug Research. (pp. 302-318) edited by G. Keri and I. Toth. London & New York: Taylor & Francis.
Clinical pharmacology and adverse effects
Mather, L. E. and Smith, M. T. (1999). Clinical pharmacology and adverse effects. Opioids in pain control: Basic and clinical aspects. (pp. 188-211) edited by Christoph Stein. New Jersey, USA: Cambridge University Press.
Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation
Shepherd, Andrew J., Rice, Andrew SC. and Smith, Maree T. (2023). Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation. Current Opinion in Pharmacology, 73 102415, 102415. doi: 10.1016/j.coph.2023.102415
Imam, Mohammad Zafar, Ghassabian, Sussan, Kuo, Andy, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2023). In Vitro Assessment of the Metabolic Stability of Two Novel Endomorphin-2 Analogs, CYX-5 and CYX-6, in Rat Liver Microsomes. European Journal of Drug Metabolism and Pharmacokinetics, 48 (4), 463-466. doi: 10.1007/s13318-023-00828-6
The NLRP3 inflammasome: role in the pathobiology of chronic pain
Chen, Chen and Smith, Maree T. (2023). The NLRP3 inflammasome: role in the pathobiology of chronic pain. Inflammopharmacology, 31 (4), 1589-1603. doi: 10.1007/s10787-023-01235-8
Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2023). Multitargeted opioid ligand discovery as a strategy to retain analgesia and reduce opioid-related adverse effects. Journal of Medicinal Chemistry, 66 (6), 3746-3784. doi: 10.1021/acs.jmedchem.2c01695
Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2023). CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats. Pharmacological Reports, 75 (3), 634-646. doi: 10.1007/s43440-023-00446-8
Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy (Adv. Therap. 12/2022). Advanced Therapeutics, 5 (12) 2270030, 1-1. doi: 10.1002/adtp.202270030
Smith, A. E., Muralidharan, A. and Smith, M. T. (2022). Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials. Discover Oncology, 13 (1) 108, 1-23. doi: 10.1007/s12672-022-00569-z
Kong, Dehui, Saqer, Alaa A., Carpinelli de Jesus, Matheus, Khan, Nemat, Jones, Alun, Blanchfield, Joanne T., Smith, Maree T. and Williams, Craig M. (2022). Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain. Bioorganic and Medicinal Chemistry, 69 116889, 1-10. doi: 10.1016/j.bmc.2022.116889
Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy. Advanced Therapeutics, 5 (12) 2200109, 2200109. doi: 10.1002/adtp.202200109
Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial
Smith, Maree T. (2022). Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial. Pain, Publish Ahead of Print (S1), S15-S28. doi: 10.1097/j.pain.0000000000002675
Han, Felicity Y., Brockman, David A., Nicholson, Janet R., Corradini, Laura and Smith, Maree Therese (2022). Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat. Behavioural Pharmacology, 33 (1), 23-31. doi: 10.1097/fbp.0000000000000663
Journey to the market: The evolution of biodegradable drug delivery systems
Zhu, Minze, Whittaker, Andrew K., Han, Felicity Y. and Smith, Maree T. (2022). Journey to the market: The evolution of biodegradable drug delivery systems. Applied Sciences, 12 (2) 935. doi: 10.3390/app12020935
Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources
Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2022). Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources. Journal of Medicinal Chemistry, 65 (3) acs.jmedchem.0c01915, 1612-1661. doi: 10.1021/acs.jmedchem.0c01915
Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice
Xu, Weizhi, Maqbool, Faheem, Kumar, Vinod, Falconer, James R., Cui, Cedric S., Woodruff, Trent M., Borges, Karin, Whittaker, Andrew K., Smith, Maree T. and Han, Felicity Y. (2021). Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice. Drug Delivery and Translational Research, 12 (10), 2518-2526. doi: 10.1007/s13346-021-01093-3
Han, Felicity Y., Brockman, David A., Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2021). Pharmacological characterization of the chronic phase of the monoiodoacetate‐induced rat model of osteoarthritis pain in the knee joint. Clinical and Experimental Pharmacology and Physiology, 48 (11) 1440-1681.13551, 1515-1522. doi: 10.1111/1440-1681.13551
Editorial: verification of animal pain models by reverse translation
Caudle, Robert M., Smith, Maree Therese and Romero-Sandoval, E. Alfonso (2021). Editorial: verification of animal pain models by reverse translation. Frontiers in Pharmacology, 12 778880, 778880. doi: 10.3389/fphar.2021.778880
Optimisation of a microfluidic method for the delivery of a small peptide
Han, Felicity Y., Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria, Jiang, Xingyu, Woodruff, Trent M., Whittaker, Andrew K. and Smith, Maree T. (2021). Optimisation of a microfluidic method for the delivery of a small peptide. Pharmaceutics, 13 (9) 1505, 1505. doi: 10.3390/pharmaceutics13091505
Kuo, Andy, Corradini, Laura, Nicholson, Janet R. and Smith, Maree T. (2021). Assessment of the anti-allodynic and anti-hyperalgesic efficacy of a glycine transporter 2 inhibitor relative to pregabalin, duloxetine and indomethacin in a rat model of cisplatin-induced peripheral neuropathy. Biomolecules, 11 (7) 940, 1-17. doi: 10.3390/biom11070940
Xu, Weizhi, Zhao, Zonglan, Falconer, James, Whittaker, Andrew K., Popat, Amirali, Smith, Maree T., Kumeria, Tushar and Han, Felicity Y. (2021). Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO2 process. Drug Delivery and Translational Research, 12 (3), 676-694. doi: 10.1007/s13346-021-00991-w
Park, Thomas S.W., Khan, Nemat, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2021). Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods. Clinical and Experimental Pharmacology and Physiology, 48 (1) 1440-1681.13402, 96-106. doi: 10.1111/1440-1681.13402
Zhu, Minze, Whittaker, Andrew K., Jiang, Xingyu, Tang, Rupei, Li, Xuanyu, Xu, Weizhi, Fu, Changkui, Smith, Maree T. and Han, Felicity Y. (2020). Use of microfluidics to fabricate bioerodable lipid hybrid nanoparticles containing hydromorphone or ketamine for the relief of intractable pain. Pharmaceutical Research, 37 (10) 211, 1-12. doi: 10.1007/s11095-020-02939-0
Agnew-Francis, Kylie A., Tang, Yu Cheng, Lin, Xin, Low, Yu Shang, Wun, Shun Jie, Kuo, Andy, Elias, S. M. A. Sayeed Ibn, Lonhienne, Thierry G., Condon, Nicholas, Pimentel, Bruna Natalia Alves da Silva, Vergani, Carlos, Smith, Maree T., Fraser, James A., Williams, Craig M. and Guddat, Luke W (2020). Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris. ACS infectious diseases, 6 (11) acsinfecdis.0c00229, 2901-2912. doi: 10.1021/acsinfecdis.0c00229
Imam, Mohammad Zafar, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2020). Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain. Pharmacological Reports, 72 (5), 1418-1425. doi: 10.1007/s43440-020-00145-8
Kuo, Andy, Lourdesamy, Jacintha, Nicholson, Janet R., Corradini, Laura and Maree, Smith T. (2020). Assessment of the anti‐hyperalgesic efficacy of J‐2156, relative to clinically available analgesic/adjuvant agents in a rat model of mild to moderate chronic mechanical low back pain (LBP). Clinical and Experimental Pharmacology and Physiology, 47 (12) 1440-1681.13383, 1912-1922. doi: 10.1111/1440-1681.13383
Edwards, Stephen R., Khan, Nemat, Coulson, Elizabeth J. and Smith, Maree T. (2020). Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease. Clinical and Experimental Pharmacology and Physiology, 47 (10) 1440-1681.13363, 1740-1750. doi: 10.1111/1440-1681.13363
Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation
Han, Felicity Y., Liu, Yun, Kumar, Vinod, Xu, Weizhi, Yang, Guangze, Zhao, Chun-Xia, Woodruff, Trent M., Whittaker, Andrew K. and Smith, Maree T. (2020). Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation. International Journal of Pharmaceutics, 581 119291, 119291. doi: 10.1016/j.ijpharm.2020.119291
Kuo, Andy, Magiera, Julia, Rethwan, Nursyazwani, Andersson, Åsa, Leen Lam, Ai, Wyse, Bruce, Meutermans, Wim, Lewis, Richard and Smith, Maree (2020). In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile. European Journal of Pharmacology, 872 172947, 172947. doi: 10.1016/j.ejphar.2020.172947
Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2020). Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine. European Journal of Pharmacology, 871 172918, 172918. doi: 10.1016/j.ejphar.2020.172918
Countering opioid-induced respiratory depression by non-opioids that are respiratory stimulants
Imam, Mohammad Zafar, Kuo, Andy and Smith, Maree T. (2020). Countering opioid-induced respiratory depression by non-opioids that are respiratory stimulants. F1000Research, 9 91, 91. doi: 10.12688/f1000research.21738.1
Shenoy, Priyank A., Kuo, Andy, Leparc, German, Hildebrandt, Tobias, Rust, Werner, Nicholson, Janet R., Corradini, Laura, Vetter, Irina and Smith, Maree T. (2019). Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell-induced bone pain. Clinical and Experimental Pharmacology and Physiology, 46 (12) 1440-1681.13165, 1201-1215. doi: 10.1111/1440-1681.13165
Park, Thomas S.W., Khan, Nemat, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2019). J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain. Biomedicine and Pharmacotherapy, 117 109056, 109056. doi: 10.1016/j.biopha.2019.109056
Houston, Sevan D., Fahrenhorst-Jones, Tyler, Xing, Hui, Chalmers, Benjamin A., Sykes, Melissa L., Stok, Jeanette E., Farfan Soto, Clementina, Burns, Jed M., Bernhardt, Paul V., De Voss, James J., Boyle, Glen M., Smith, Maree T., Tsanaktsidis, John, Savage, G. Paul, Avery, Vicky M. and Williams, Craig M. (2019). The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement. Organic and Biomolecular Chemistry, 17 (28), 6790-6798. doi: 10.1039/c9ob01238a
Adiraju, Santosh Kumar Sreevatsav, Shekar, Kiran, Tesar, Peter, Naidoo, Rishendran, Rapchuk, Ivan, Belz, Stephen, Fraser, John F., Smith, Maree T. and Ghassabian, Sussan (2019). Study Protocol for a Pilot, Open-Label, Prospective, and Observational Study to Evaluate the Pharmacokinetics of Drugs Administered to Patients during Extracorporeal Circulation; Potential of In Vivo Cytochrome P450 Phenotyping to Optimise Pharmacotherapy. Methods and Protocols, 2 (2) 38, 38-12. doi: 10.3390/mps2020038
Nitric oxide modulates μ‐opioid receptor function in vitro
Huang, Lillian, Wyse, Bruce D., Williams, Craig M. and Smith, Maree T. (2019). Nitric oxide modulates μ‐opioid receptor function in vitro. Clinical and Experimental Pharmacology and Physiology, 46 (7) 1440-1681.13091, 676-685. doi: 10.1111/1440-1681.13091
Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2019). Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods. Inflammopharmacology, 27 (2), 387-396. doi: 10.1007/s10787-018-00551-8
Bioerodable ketamine-loaded microparticles fabricated using dissolvable hydrogel template technology
Zhu, Minze, Whittaker, Andrew K., Smith, Maree T. and Han, Felicity Y. (2019). Bioerodable ketamine-loaded microparticles fabricated using dissolvable hydrogel template technology. Journal of Pharmaceutical Sciences, 108 (3), 1220-1226. doi: 10.1016/j.xphs.2018.10.029
Cyclooctatetraene: a bioactive cubane paradigm complement
Xing, Hui, Houston, Sevan D., Chen, Xuejie, Ghassabian, Sussan, Fahrenhorst-Jones, Tyler, Kuo, Andy, Murray, Cody-Ellen P., Conn, Kyna-Anne, Jaeschke, Kara N., Jin, Da-Yun, Pasay, Cielo, Bernhardt, Paul V., Burns, Jed M., Tsanaktsidis, John, Savage, G. Paul, Boyle, Glen M., De Voss, James J., McCarthy, James, Walter, Gimme H., Burne, Thomas H. J., Smith, Maree T., Tie, Jian-Ke and Williams, Craig M. (2019). Cyclooctatetraene: a bioactive cubane paradigm complement. Chemistry: A European Journal, 25 (11), 2729-2734. doi: 10.1002/chem.201806277
Sustained-release hydromorphone microparticles produced by supercritical fluid polymer encapsulation
Han, Felicity Y., Whittaker, Andrew, Howdle, Steven M., Naylor, Andrew, Shabir-Ahmed, Anjumn and Smith, Maree T. (2019). Sustained-release hydromorphone microparticles produced by supercritical fluid polymer encapsulation. Journal of Pharmaceutical Sciences, 108 (2), 811-814. doi: 10.1016/j.xphs.2018.09.021
Han, Felicity, Whittaker, Andrew, Howdle, Steven, Naylor, Andrew, Shabir-Ahmed, Anjumn, Zhang, Cheng and Smith, Maree (2018). Formulation of bioerodible ketamine microparticles as an analgesic adjuvant treatment produced by supercritical fluid polymer encapsulation. Pharmaceutics, 10 (4) 264, 264. doi: 10.3390/pharmaceutics10040264
Sreevatsav Adiraju, Santosh Kumar, Shekar, Kiran, Fraser, John F., Smith, Maree T. and Ghassabian, Sussan (2018). An improved LC-MS/MS method for simultaneous evaluation of CYP2C9, CYP2C19, CYP2D6 and CYP3A4 activity. Bioanalysis, 10 (19), 1577-1590. doi: 10.4155/bio-2018-0102
Han, Felicity Y., Kuo, Andy, Nicholson, Janet R., Corradinni, Laura and Smith, Maree T. (2018). Comparative analgesic efficacy of pregabalin administered according to either a prevention protocol or an intervention protocol in rats with cisplatin-induced peripheral neuropathy. Clinical and Experimental Pharmacology and Physiology, 45 (10), 1067-1075. doi: 10.1111/1440-1681.12971
Kuo, Andy and Smith, Maree T. (2018). In vivo profiling of four centrally administered opioids for antinociception, constipation and respiratory depression: between colony differences in Sprague Dawley rats. Clinical and Experimental Pharmacology & Physiology, 45 (10), 1056-1066. doi: 10.1111/1440-1681.12972
Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2018). Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675). Angewandte Chemie - International Edition, 57 (28), 8359-8359. doi: 10.1002/anie.201711161
Richards, Georgia C., Lluka, Lesley J., Smith, Maree T., Haslam, Catherine, Moore, Brendan, OʼCallaghan, James and Strong, Jenny (2018). Effects of long-term opioid analgesics on cognitive performance and plasma cytokine concentrations in patients with chronic low back pain : a cross-sectional pilot study. PAIN Reports, 3 (4) e669, e669. doi: 10.1097/pr9.0000000000000669
Park, Thomas S. W., Kuo, Andy and Smith, Maree T. (2018). Chronic low back pain: a mini-review on pharmacological management and pathophysiological insights from clinical and pre-clinical data. Inflammopharmacology, 26 (4), 1-18. doi: 10.1007/s10787-018-0493-x
Shenoy, Priyank A., Kuo, Andy, Khan, Nemat, Gorham, Louise, Nicholson, Janet, Corradini, Laura, Vetter, Irina and Smith, Maree T. (2018). The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain. Frontiers in Pharmacology, 9 (MAY) 495, 495. doi: 10.3389/fphar.2018.00495
Moosavi, Seyed Mojtaba, Shekar, Kiran, Fraser, John F., Smith, Maree T. and Ghassabian, Sussan (2018). An improved liquid chromatography tandem mass spectrometry (LC-MS/MS) method for quantification of dexmedetomidine concentrations in samples of human plasma. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1073, 118-122. doi: 10.1016/j.jchromb.2017.12.006
Lee, Jia Yu Peppermint, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, King, Glenn F., Smith, Maree T. and Rash, Lachlan D. (2018). Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. British Journal of Pharmacology, 175 (12), 2204-2218. doi: 10.1111/bph.14089
Synthesis and Biological Evaluation of Fentanyl Analogues Modified at Phenyl Groups with Alkyls
Qin, Yajuan, Ni, Luofan, Shi, Jiawei, Zhu, Zhiying, Shi, Saijian, Lam, Ai-Leen, Magiera, Julia, Sekar, Sunderajhan, Kuo, Andy, Smith, Maree T. and Li, Tingyou (2018). Synthesis and Biological Evaluation of Fentanyl Analogues Modified at Phenyl Groups with Alkyls. ACS Chemical Neuroscience, 10 (1) acschemneuro.8b00363, 201-208. doi: 10.1021/acschemneuro.8b00363
Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan and Smith, Maree T. (2017). Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression. Neuropharmacology, 131, 238-255. doi: 10.1016/j.neuropharm.2017.12.032
Adiraju, Santosh Kumar Sreevatsav, Shekar, Kiran, Fraser, John F, Smith, Maree T and Ghassabian, Sussan (2017). Effect of cardiopulmonary bypass on cytochrome P450 enzyme activity: implications for pharmacotherapy. Drug metabolism reviews, 50 (2), 1-16. doi: 10.1080/03602532.2017.1417423
Morphine hyposensitivity in STZ-diabetic rats: reversal by dietary L-arginine treatment
Lotfipour, Shahrdad and Smith, Maree T. (2017). Morphine hyposensitivity in STZ-diabetic rats: reversal by dietary L-arginine treatment. Clinical and Experimental Pharmacology & Physiology, 45 (1), 42-49. doi: 10.1111/1440-1681.12855
Khan, Nemat, Muralidharan, Arjun and Smith, Maree T. (2017). Attenuation of the Infiltration of Angiotensin II Expressing CD3(+) T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia - A Possible Mechanism Underpinning Analgesia Produced by EMA300, An Angiotensin II Type 2 (AT(2)) Receptor Antagonist. Frontiers in Molecular Neuroscience, 10 389, 389. doi: 10.3389/fnmol.2017.00389
Khan, Nemat, Kuo, Andy, Brockman, David A, Cooper, Matthew A and Smith, Maree T (2017). Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain. Inflammopharmacology, 26 (1), 77-86. doi: 10.1007/s10787-017-0401-9
Muralidharan, Arjun, Park, Thomas S. W., Mackie, John T., Gimenez, Luiz G. S., Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2017). Establishment and characterization of a novel rat model of mechanical low back pain using behavioral, pharmacologic and histologic methods. Frontiers in Pharmacology, 8 493, 493.1-493.12. doi: 10.3389/fphar.2017.00493
Shenoy, Priyank, Kuo, Andy, Vetter, Irina and Smith, Maree T. (2017). Optimization and in vivo profiling of a refined rat model of Walker 256 breast cancer cell-induced bone pain using behavioral, radiological, histological, immunohistochemical and pharmacological methods. Frontiers in Pharmacology, 8 (JUL) 442, 442. doi: 10.3389/fphar.2017.00442
Moosavi, Seyed Mojtaba, Shekar, Kiran, Fraser, John, Smith, Maree T. and Ghassabian, Sussan (2016). High-throughput assay for quantification of the plasma concentrations of thiopental using automated solid phase extraction (SPE) directly coupled to LC–MS/MS instrumentation. Journal of Chromatography B, 1038, 80-87. doi: 10.1016/j.jchromb.2016.10.038
The Walker 256 breast cancer cell-induced bone pain model in rats
Shenoy, Priyank A., Kuo, Andy, Vetter, Irina and Smith, Maree T. (2016). The Walker 256 breast cancer cell-induced bone pain model in rats. Frontiers in Pharmacology, 7 (AUG) 286, 286. doi: 10.3389/fphar.2016.00286
Han, Felicity Y., Thurecht, Kristofer J., Whittaker, Andrew K. and Smith, Maree T. (2016). Bioerodable PLGA-based microparticles for producing sustained-release drug formulations and strategies for improving drug loading. Frontiers in Pharmacology, 7 (JUN) 185, 1-11. doi: 10.3389/fphar.2016.00185
Muralidharan, Arjun, Kuo, Andy, Jacob, Meera, Lourdesamy, Jacintha S., Melo Sores Pinho De Carvalho, Lara, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2016). Comparison of burrowing and stimuli-evoked pain behaviors as end-points in rat models of inflammatory pain and peripheral neuropathic pain. Frontiers in Behavioral Neuroscience, 10 (88) 88, 88. doi: 10.3389/fnbeh.2016.00088
Pippin, Adam B., Mohd Arshad, Zaira Hidayah, Vol, Ronald J., Nye, Jonathon A., Ghassabian, Sussan, Williams, Craig M., Mancini, Alessandra, Liotta, Dennis C., Smith, Maree T. and Goodman, Mark M. (2016). In Vitro Metabolic Stability and in Vivo Biodistribution of 3‑Methyl-4- furoxancarbaldehyde Using PET Imaging in Rats. ACS Medicinal Chemistry Letters, 7 (6), 563-567. doi: 10.1021/acsmedchemlett.5b00410
Frontispiece: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere
Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2016). Frontispiece: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere. Angewandte Chemie International Edition, 55 (11), 8359-8359. doi: 10.1002/anie.201681161
Wong, Chin Lin, Lam, Ai Leen, Smith, Maree T. and Ghassabian, Sussan (2016). Evaluation of a high-throughput peptide reactivity format assay for assessment of the skin sensitization potential of chemicals. Frontiers in Pharmacology, 7 (MAR) 53, 53. doi: 10.3389/fphar.2016.00053
Validating Eaton's hypothesis: cubane as a benzene bioisostere
Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2016). Validating Eaton's hypothesis: cubane as a benzene bioisostere. Angewandte Chemie (International Edition), 55 (11), 3580-3585. doi: 10.1002/anie.201510675
Smith, Maree T., Anand, Praveen and Rice, Andrew S. C. (2016). Selective small molecule angiotensin II type 2 (AT2) receptor antagonists for neuropathic pain: preclinical and clinical studies. Pain, 157 (Supplement 1), S33-S41. doi: 10.1097/j.pain.0000000000000369
Why different pain-killers are only effective for certain types of pain
Smith, Maree (2015, 12 14). Why different pain-killers are only effective for certain types of pain
Ghassabian, Sussan, Griffiths, Lyn and Smith, Maree T (2015). A novel fully validated LC-MS/MS method for quantification of pyridoxal-5'-phosphate concentrations in samples of human whole blood. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1000, 77-83. doi: 10.1016/j.jchromb.2015.07.019
Han, Felicity Y., Thurecht, Kristofer J., Lam, Ai-Leen, Whittaker, Andrew K. and Smith, Maree T. (2015). Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain. Journal of Pharmaceutical Sciences, 104 (7), 2334-2344. doi: 10.1002/jps.24497
Smith, Maree T., Wyse, Bruce D., Edwards, Stephen R., El-Taminy, Mahmoud, Gaetano, Giacinto and Gavin, Paul (2015). Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture, TPM) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure. Journaal of Pharmaceutical Sciences, 104 (7), 2388-2396. doi: 10.1002/jps.24502
Huang, Lillian Y., Tsui, Debbie Y., Williams, Craig M., Wyse, Bruce D. and Smith, Maree T. (2015). The Furoxan Nitric Oxide Donor, PRG150, Evokes Dose-Dependent Analgesia in a Rat Model of Painful Diabetic Neuropathy (PDN). Clinical and Experimental Pharmacology and Physiology, 42 (9), 921-929. doi: 10.1111/1440-1681.12442
In vivo High Angular Resolution Diffusion-Weighted Imaging of Mouse Brain at 16.4 Tesla
Alomair, Othman I, Brereton, Ian M, Smith, Maree T, Galloway, Graham J and Kurniawan, Nyoman D (2015). In vivo High Angular Resolution Diffusion-Weighted Imaging of Mouse Brain at 16.4 Tesla. Plos One, 10 (6) e0130133, e0130133. doi: 10.1371/journal.pone.0130133
Neurotrophins and neuropathic pain: role in pathobiology
Khan, Nemat and Smith, Maree T. (2015). Neurotrophins and neuropathic pain: role in pathobiology. Molecules, 20 (6), 10657-10688. doi: 10.3390/molecules200610657
Khan, Nemat, Gordon, Richard, Woodruff, Trent M. and Smith, Maree T. (2015). Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cord. Pharmacology Research and Perspectives, 3 (3) e00137, 1-16. doi: 10.1002/prp2.137
In vitro methods for hazard assessment of industrial chemical - opportunities and challenges
Wong, Chin Lin, Ghassabian, Sussan, Smith, Maree T. and Lam, Ai-Leen (2015). In vitro methods for hazard assessment of industrial chemical - opportunities and challenges. Frontiers in Pharmacology, 6 (94) 94, 1-13. doi: 10.3389/fphar.2015.00094
Angiotensin II Type 2-Receptor: New Clinically Validated Target in the Treatment of Neuropathic Pain
Rice, A. S. C. and Smith, M. T. (2015). Angiotensin II Type 2-Receptor: New Clinically Validated Target in the Treatment of Neuropathic Pain. Clinical Pharmacology and Therapeutics, 97 (2), 128-130. doi: 10.1002/cpt.29
Ghassabian, Sussan, Rethwan, Nur Syazwani Ahmad, Griffiths, Lyn and Smith, Maree T. (2014). Fully validated LC–MS/MS method for quantification of homocysteine concentrations in samples of human serum: a new approach. Journal of Chromatography B, 972, 14-21. doi: 10.1016/j.jchromb.2014.09.032
Khan, Nemat, Woodruff, Trent M. and Smith, Maree T. (2014). Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 126, 13-27. doi: 10.1016/j.pbb.2014.09.003
Han, Felicity Yaqin, Wyse, Bruce D. and Smith, Maree T. (2014). Optimization and pharmacological characterization of a refined cisplatin-induced rat model of peripheral neuropathic pain. Behavioural Pharmacology, 25 (8), 732-740. doi: 10.1097/FBP.0000000000000090
Targeting angiotensin II type 2 receptor pathways to treat neuropathic pain and inflammatory pain
Smith, Maree T. and Muralidharan, Arjun (2014). Targeting angiotensin II type 2 receptor pathways to treat neuropathic pain and inflammatory pain. Expert Opinion On Therapeutic Targets, 19 (1), 25-35. doi: 10.1517/14728222.2014.957673
Edwards, Stephen R., Hamlin, Adam S., Marks, Nicola, Coulson, Elizabeth J. and Smith, Maree T. (2014). Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models Of Alzheimer's disease. Clinical and Experimental Pharmacology and Physiology, 41 (10), 798-806. doi: 10.1111/1440-1681.12277
Kuo, Andy and Smith, Maree T. (2014). Theoretical and practical applications of the intracerebroventricular route for CSF sampling and drug administration in CNS drug discovery research: a mini review. Journal of Neuroscience Methods, 233, 166-171. doi: 10.1016/j.jneumeth.2014.06.006
Smith, Maree T., Lau, Tanya, Wallace, Victoria C. J., Wyse, Bruce D. and Rice, Andrew S. C. (2014). Analgesic efficacy of small-molecule angiotensin II type 2 receptor antagonists in a rat model of antiretroviral toxic polyneuropathy. Behavioural Pharmacology, 25 (2), 137-146. doi: 10.1097/FBP.0000000000000025
Cai, Jun, Song, Bowen, Cai, Yunxin, Ma, Yu, Lam, Ai-leen, Magiera, Julia, Sekar, Sunder, Wyse, Bruce D., Ambo, Akihiro, Sasaki, Yusuke, Lazarus, Lawrence H., Smith, Maree T. and Li, Tingyou (2014). Endomorphin analogues with mixed mu-opioid (MOP) receptor agonism/delta-opioid (DOP) receptor antagonism and lacking beta-arrestin2 recruitment activity. Biorganic and Medicinal Chemistry, 22 (7), 2208-2219. doi: 10.1016/j.bmc.2014.02.015
Kuo, A., Wyse, B. D., Meutermans, W. and Smith, M. T. (2014). In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile. British Journal of Pharmacology, Accepted Article (2), 1-48. doi: 10.1111/bph.12696
Muralidharan, Arjun, Wyse, Bruce D. and Smith, Maree T. (2014). Analgesic efficacy and mode of action of a selective small molecule angiotensin II type 2 receptor antagonist in a rat model of prostate cancer-induced bone pain. Pain Medicine, 15 (1), 93-110. doi: 10.1111/pme.12258
Current developments in MRI for assessing rodent models of multiple sclerosis
Alomair, Othman I., Smith, Maree T., Brereton, Ian M., Galloway, Graham J. and Kurniawan, Nyoman D. (2014). Current developments in MRI for assessing rodent models of multiple sclerosis. Future Neurology, 9 (4), 487-511. doi: 10.2217/FNL.14.33
Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN)
Han, Yaqin and Smith, Maree T. (2013). Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN). Frontiers in Pharmacology, 4 Article 156, 1-16. doi: 10.3389/fphar.2013.00156
Khan, Nemat and Smith, Maree T. (2013). Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models. Inflammopharmacology, 22 (1), 1-22. doi: 10.1007/s10787-013-0195-3
Comment On "protective Arms of the Renin-Angiotensin System in Neurological Disease"
Smith, Maree T. and Muralidharan, Arjun (2013). Comment On "protective Arms of the Renin-Angiotensin System in Neurological Disease". Clinical and Experimental Pharmacology and Physiology, 40 (11), 838-838. doi: 10.1111/1440-1681.12169
Muralidharan, Arjun and Smith, Maree T. (2013). Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments. Inflammopharmacology, 21 (5), 339-363. doi: 10.1007/s10787-013-0183-7
Smith, Maree T., Woodruff, Trent M., Wyse, Bruce D., Muralidharan, Arjun and Walther, Thomas (2013). A small molecule angiotensin II type 2 receptor (AT2R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia. Pain Medicine, 14 (10), 1557-1568. doi: 10.1111/pme.12157
Smith, Maree T., Wyse, Bruce D. and Edwards, Stephen R. (2013). Small molecule angiotensin II type 2 receptor (AT2R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats. Pain Medicine, 14 (5), 692-705. doi: 10.1111/pme.12063
Varamini, Pegah, Goh, Wei Huang, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2013). Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation. Bioorganic & Medicinal Chemistry, 21 (7), 1898-1904. doi: 10.1016/j.bmc.2013.01.044
Shekar, Kiran, Roberts, Jason A., Smith, Maree T., Fung, Yoke L. and Fraser, John F. (2013). The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation. BMC Anesthesiology, 13 (1) 7, 7.1-7.10. doi: 10.1186/1471-2253-13-7
Muralidharan, Arjun, Wyse, Bruce D. and Smith, Maree T. (2013). Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioural, pharmacological, radiological, histological and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 106, 33-46. doi: 10.1016/j.pbb.2013.02.020
The erythropoietin-derived peptide ARA290 reverses mechanical allodynia in the neuritis model
Pulman, K. G. T., Smith, M., Mengozzi, M., Ghezzi, P. and Dilley, A. (2012). The erythropoietin-derived peptide ARA290 reverses mechanical allodynia in the neuritis model. Neuroscience, 233, 174-183. doi: 10.1016/j.neuroscience.2012.12.022
Shekar, Kiran, Roberts, Jason A., Welsh, Susan, Buscher, Hergen, Rudham, Sam, Burrows, Fay, Ghassabian, Sussan, Wallis, Steven C., Levkovich, Bianca, Pellegrino, Vin, McGuiness, Shay, Parke, Rachael, Gilder, Eileen, Barnett, Adrian G., Walsham, James, Mullany, Daniel V., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012). ASAP ECMO: antibiotic, sedative and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO. BMC Anesthesiology, 12 (1) 29, 29.1-29.9. doi: 10.1186/1471-2253-12-29
Sedation during extracorporeal membrane oxygenation-why more is less
Shekar, K., Roberts, J. A., Ghassabian, S., Mullany, D. V., Ziegenfuss, M., Smith, M. T., Fung, Y. L. and Fraser, J. F. (2012). Sedation during extracorporeal membrane oxygenation-why more is less. Anaesthesia and Intensive Care, 40 (6), 1067-1069.
Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?
Shekar, Kiran, Roberts, Jason A., Ghassabian, Sussan, Mullany, Daniel V., Wallis, Steven C., Smith, Maree T. and Fraser, John F. (2012). Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?. Journal of Antimicrobial Chemotherapy, 68 (3), 726-727. doi: 10.1093/jac/dks435
Shekar, Kiran, Roberts, Jason A., McDonald, Charles I., Fisquet, Stephanie, Barnett, Adrian G., Mullany, Daniel V., Ghassabian, Sussan, Wallis, Steven C., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012). Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation. Critical Care, 16 (5) R194, R194.1-R194.7. doi: 10.1186/cc11679
Varamini, Pegah, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2012). Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation. PLoS One, 7 (8 Article. No.e41909) e41909, e41909. doi: 10.1371/journal.pone.0041909
Ghassabian, Sussan, Moosavi, Seyed Mojtaba, Valero, Yarmarly Guerra, Shekar, Kiran, Fraser, John F. and Smith, Maree T. (2012). High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS. Journal of Chromatography B, 903, 126-133. doi: 10.1016/j.jchromb.2012.07.005
Pregabalin for the treatment of fibromyalgia
Smith, Maree T. and Moore, Brendan J. (2012). Pregabalin for the treatment of fibromyalgia. Expert Opinion on Pharmacotherapy, 13 (10), 1527-1533. doi: 10.1517/14656566.2012.687373
Synthesis and biological evaluation of an orally active glycosylated endomorphin-1
Varamini, Pegah, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2012). Synthesis and biological evaluation of an orally active glycosylated endomorphin-1. Journal of Medicinal Chemistry, 55 (12), 5859-5867. doi: 10.1021/jm300418d
Shekar, Kiran, Fung, Yoke L., Diab, Sara, Mullany, Daniel V., McDonald, Charles I, Dunster, Kimble R., Fisquet, Kimble R, Platts, David G., Stewart, David G, Wallis, Steven C., Smith, Maree T., Roberts, Jason A. and Fraser, John F. (2012). Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions. Critical Care and Resuscitation, 14 (2), 105-111.
Shekar, Kiran, Fung, Yoke L., Diab, Sara, Mullany, Daniel V., McDonald, Charles I., Dunster, Kimble R., Fisquet, Stephanie, Platts, David G., Stewart, David, Wallis, Steven C., Smith, Maree T., Roberts, Jason A. and Fraser, John F. (2012). Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions. Critical Care and Resuscitation, 14 (2), 105-111.
Ghassabian, Sussan, Wright, Linda A., deJager, Andrew D. and Smith, Maree T. (2012). Development and validation of a sensitive solid-phase-extraction (SPE) method using high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) for determination of risedronate concentrations in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 881-82, 34-41. doi: 10.1016/j.jchromb.2011.11.031
Pharmacogenetics of pain and analgesia
Smith, M. T. and Muralidharan, A. (2012). Pharmacogenetics of pain and analgesia. Clinical Genetics, 82 (4), 321-330. doi: 10.1111/j.1399-0004.2012.01936.x
Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation
Shekar, Kiran, Fraser, John F., Smith, Maree T. and Roberts, Jason A. (2012). Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation. Journal of Critical Care, 27 (6), 741.e9-741.e18. doi: 10.1016/j.jcrc.2012.02.013
Muralidharan, Arjun and Smith, Maree T. (2011). Pain, analgesia and genetics. Journal of Pharmacy and Pharmacology, 63 (11), 1387-1400. doi: 10.1111/j.2042-7158.2011.01340.x
Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial
Gray, Paul, Kirby, Julie, Smith, Maree T., Cabot, Peter J., Williams, Bronwyn, Doecke, James and Cramond, Tess (2011). Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial. Pain, 152 (6), 1279-1288. doi: 10.1016/j.pain.2011.01.055
Otto, Kathleen J., Wyse, Bruce D., Cabot, Peter J. and Smith, Maree T. (2011). Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats. Pain Medicine, 12 (5), 782-793. doi: 10.1111/j.1526-4637.2011.01102.x
Otto, Kathleen J., Wyse, Bruce D., Cabot, Peter J. and Smith, Maree T. (2011). Longitudinal study of painful diabetic neuropathy in the Zucker diabetic fatty rat model of type 2 diabetes: Impaired basal G-protein activity appears to underpin marked morphine hyposensitivity at 6 months. Pain Medicine, 12 (3), 437-450. doi: 10.1111/j.1526-4637.2011.01067.x
Dredge, K, Hammond, E, Handley, P, Gonda, TJ, Smith, MT, Vincent, C, Brandt, R, Ferro, V and Bytheway, I (2011). PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. British Journal of Cancer, 104 (5), 635-642. doi: 10.1038/bjc.2011.11
Smith, Maree T. and Muralidharan, Arjun (2010). Pharmacogenetics. Pain: Clinical Updates, 18 (8), 1-8.
Zin, Che S., Nissen, Lisa M., O'Callaghan, James P., Duffull, Stephen B., Smith, Maree T. and Moore, Brendan J. (2010). A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin. Journal of Pain, 11 (5), 462-471. doi: 10.1016/j.jpain.2009.09.003
Zin, Che S., Nissen, Lisa M., O'Callaghan, James P., Moore, Brendan J. and Smith, Maree T. (2010). Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management. Pain Medicine, 11 (4), 550-561. doi: 10.1111/j.1526-4637.2010.00821.x
Brust, Andreas, Palant, Elka, Croker, Daniel E., Colless, Barbara, Drinkwater, Roger, Patterson, Brad, Schroeder, Christina I., Wilson, David, Nielsen, Carsten K., Smith, Maree T., Alewood, Danne, Alewood, Paul F and Lewis, Richard J. (2009). X-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. Journal of Medicinal Chemistry, 52 (22), 6991-7002. doi: 10.1021/jm9003413
South, Samantha M., Edwards, Stephen R. and Smith, Maree T. (2009). Antinociception versus serum concentration relationships following acute administration of intravenous morphine in male and female Sprague-dawley rats: Differences between the tail flick and hot plate nociceptive tests. Clinical and Experimental Pharmacology and Physiology, 36 (1), 20-28. doi: 10.1111/j.1440-1681.2008.05019.x
Hemstapat, K., Le, L., Edwards, S. R. and Smith, M. T. (2009). Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A (2-17) following spinal and supraspinal routes of administration. Pharmacology, Biochemistry and Behaviour, 93 (4), 498-505. doi: 10.1016/j.pbb.2009.06.016
Innovation in drug development
Smith, M.T. (2009). Innovation in drug development. BioSpectrum Asia CRAMS Resources Guide, 52-53.
Differences between and combinations of opiods re-visited
Smith, Maree T. (2008). Differences between and combinations of opiods re-visited. Current Opinion in Anaesthesiology, 21 (5), 596-601. doi: 10.1097/ACO.0b013e32830a4c4a
Zin, Che S., Nissen, Lisa M., Smith, Maree T., O'Callaghan, James P. and Moore, Brendan J. (2008). An update on the pharmcological management of post-herpetic neuralgia and painful diabetic neuropathy. CNS Drugs, 22 (5), 417-442. doi: 10.2165/00023210-200822050-00005
Chan, S., Edwards, S. R., Wyse, B. D. and Smith, M. T. (2008). Sex differences in the pharmacokinetics, oxidative metabolism and oral bioactivity of oxycodone in the sprague-dawley rat. Clinical and Experimental Pharmacology and Physiology, 35 (3), 295-302. doi: 10.1111/j.1440-1681.2007.04821.x
Edwards, S. R., Mather, L. E. and Smith, M. T. (2007). Studies with ketamine and alfentanil following Freund's complete adjuvant-induced inflammation in rats. Clinical and Experimental Pharmacology and Physiology, 34 (5-6), 414-420. doi: 10.1111/j.1440-1681.2007.04581.x
Edwards, Stephen R. and Smith, Maree T. (2007). Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Chromatography B, 848 (2), 264-270. doi: 10.1016/j.jchromb.2006.10.039
Nielsen, Carsten K., Ross, Fraser B., Lotfipour, Shahrdad, Saini, Kamal S., Edwards, Stephen R. and Smith, Maree T. (2007). Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain. Pain, 132 (3), 289-300. doi: 10.1016/j.pain.2007.03.022
Smith, Maree T., Edwards, Stephen R. and Nielsen, Carsten K. (2007). Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration. Anesthesiology, 106 (5), 1063-1064. doi: 10.1097/01.anes.0000265176.75372.ed
Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain
Nielsen, Carsten K., Lewis, Richard J., Alewood, Dianne, Drinkwater, Roger, Palant, Elka, Patterson, Margaret, Yaksh, Tony L, McCumber, Damon and Smith, Maree T. (2005). Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain, 118 (1-2), 112-124. doi: 10.1016/j.pain.2005.08.002
Co-administration of oxycodone and morphine and analgesic synergy re-examined
Smith, MT and de la Iglesia, FA (2005). Co-administration of oxycodone and morphine and analgesic synergy re-examined. British Journal of Clinical Pharmacology, 59 (4), 486-487. doi: 10.1111/j.1365-2125.2005.02345_1.x
Huang, L., Edwards, S. R. and Smith, M. T. (2005). Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague-Dawley rats: Influence of streptozotocin-induced diabetes. Pharmaceutical Research, 22 (9), 1489-1498. doi: 10.1007/s11095-005-6154-y
Edwards, S. R. and Smith, M. T. (2005). Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Chromatography B, 814 (2), 241-249. doi: 10.1016/j.jchromb.2004.10.035
Ladd, L. A., Kam, P. C., Williams, D. B., Wright, A. W. E., Smith, M. T. and Mather, L. E. (2005). Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions. British Journal of Clinical Pharmacology, 59 (5), 524-535. doi: 10.1111/j.1365-2125.2005.02368.x
Leck, KJ, Bartlett, SE, Smith, MT, Megirian, D, Holgate, J, Powell, KL, Matthaei, KI and Hendry, IA (2004). Deletion of guanine nucleotide binding protein az subunit in mice induces a gene dose dependent tolerance to morphine. Neuropharmacology, 46 (6), 836-846. doi: 10.1016/j.neuropharm.2003.11.024
Hemstapat, K, Smith, M. T. and Monteith, G. R. (2004). Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: Potential application to biomolecular screening. Journal of Pharmacological and Toxicological Methods, 49 (2), 81-87. doi: 10.1016/j.vascn.2003.10.002
Hemstapat, K., Monteith, G. R., Smith, D. and Smith, M. T. (2003). Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones. Anesthesia & Analgesia, 97 (2), 494-505. doi: 10.1213/01.ANE.0000059225.40049.99
Smith, M. T. (2003). Managing diabetic neuropathy. Australian Pharmacist, 22 (10), 782-787.
Hemstapat, K., Smith, S. A., Monteith, G. R. and Smith, M. T. (2003). The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones. Pharmacology & Toxicology, 93 (4), 197-200. doi: 10.1034/j.1600-0773.2003.930408.x
The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes
Wei, M., Ong, L., Smith, M. T., Ross, F. B., Schmid, K., Hoey, A., Burstow, D. J. and Brown, L. C. (2003). The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes. Heart, Lung and Circulation, 2003 (12), 44-50. doi: 10.1046/j.1444-2892.2003.00160.x
Smith, M. T., Cabot, P. J., Ross, F. B., Robertson, A. D. and Lewis, R. J. (2002). The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.. Pain, 96 (1-2), 119-127. doi: 10.1016/S0304-3959(01)00436-5
South, Samantha M., Wright, Andrew W. E., Lau, Michael, Mather, Laurence E. and Smith, Maree T. (2001). Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance. Journal of Pharmacology and Experimental Therapeutics, 297 (1), 446-457.
Analgesic tolerance to opioids
South, S. M. and Smith, M. T. (2001). Analgesic tolerance to opioids. Pain: Clinical Updates, 9 (5), 1-4.
Wright, AWE, Mather, LE and Smith, MT (2001). Hydromorphone-3-glucuronide - A more potent neuro-excitant than its structural analogue, morphine-3-glucuronide. Life Sciences, 69 (4), 409-420. doi: 10.1016/S0024-3205(01)01133-X
Nissen, L. M., Tett, S. E., Cramond, T., Williams, B. and Smith, M. T. (2001). Opioid analgesic prescribing and use - an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital. British Journal of Clinical Pharmacology, 52 (6), 693-698. doi: 10.1046/j.0306-5251.2001.01502.x
The role of morphine-6-glucuronide (M6G) in pain control
Smith, Maree T. and South, Samantha M. (2001). The role of morphine-6-glucuronide (M6G) in pain control. Pain Reviews, 8 (3-4), 171-191. doi: 10.1191/0968130201pr183ra
Ross, Fraser B., Wallis, Steven C. and Smith, Maree T. (2000). Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats. Pain, 84 (2-3), 421-428. doi: 10.1016/S0304-3959(99)00230-4
Nielsen, C. K., Ross, F. B. and Smith, M. T. (2000). Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat. Journal of Pharmacology and Experimental Therapeutics, 295 (1), 91-99.
Smith, MT (2000). Neuroexcitatory effects of morphine and hydromorphone: Evidence implicating the 3-glucuronide metabolites. Clinical and Experimental Pharmacology and Physiology, 27 (7), 524-528. doi: 10.1046/j.1440-1681.2000.03290.x
Smith, M. T., Nielsen, C. K., Lim-Fraser, M. Y. C., Wright, A. W. E. and Lau, M. (2000). Systemic coadministration of chloramphenicol with intravenous but not intracerebroventricular morphine markedly increases morphine antinociception and delays development of antinociceptive tolerance in rats. Drug Metabolism And Disposition, 28 (2), 236-244.
Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide
Halliday, Andrew J., Bartlett, Selena E., Colditz, Paul and Smith, Maree T. (1999). Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide. Life Sciences, 65 (2), 225-236. doi: 10.1016/S0024-3205(99)00239-8
Smith, M. T., Wright, A. W., Williams, B., Stuart, G. and Cramond, T. R. (1999). Cerebrospinal fluid and plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in patients before and after initiation of intracerebroventricular morphine for cancer pain management. Anesthesia and analgesia, 88 (1), 109-116. doi: 10.1097/00000539-199901000-00021
Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis
Keates, Helen L., Cramond, Teresa and Smith, Maree T. (1999). Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis. Anesthesia and Analgesia, 89 (2), 409-415.
Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis
Keates, HL, Cramond, T and Smith, MT (1999). Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis. Anesthesia and Analgesia, 89 (2), 409-415. doi: 10.1097/00000539-199908000-00030
Smith, Gregg D. and Smith, Maree T. (1998). The excitatory behavioral and antianalgesic pharmacology of normorphine- 3-glucuronide after intracerebroventricular administration to rats. Journal of Pharmacology and Experimental Therapeutics, 285 (3), 1157-1162.
South, SM and Smith, MT (1998). Apparent insensitivity of the hotplate latency test for detection of antinociception following intraperitoneal, intravenous or intracerebroventricular M6G administration to rats. Journal of Pharmacology And Experimental Therapeutics, 286 (3), 1326-1332.
Hydromorphone-3-glucuronide: Biochemical synthesis and preliminary pharmacological evaluation
Wright, AWE, Nocente, ML and Smith, MT (1998). Hydromorphone-3-glucuronide: Biochemical synthesis and preliminary pharmacological evaluation. Life Sciences, 63 (5), 401-411. doi: 10.1016/S0024-3205(98)00288-4
Wright, AWE and Smith, MT (1998). Improved one-step solid-phase extraction method for morphine, morphine-3-glucuronide, and morphine-6-glucuronide from plasma and quantitation using high-performance liquid chromatography with electrochemical detection. Therapeutic Drug Monitoring, 20 (2), 215-218. doi: 10.1097/00007691-199804000-00013
Preechagoon, D, Smith, MT and Prankerd, RJ (1998). Investigation of the antinociceptive efficacy and relative potency of extended duration injectable 3-acylmorphine-6-sulfate prodrugs in rats. International Journal of Pharmaceutics, 163 (1-2), 191-201. doi: 10.1016/S0378-5173(97)00380-3
Wright, AWE, Lawrence, JA, Iu, M, Cramond, T and Smith, MT (1998). Solid-phase extraction method with high-performance liquid chromatography and electrochemical detection for the quantitative analysis of oxycodone in human plasma. Journal of Chromatography B, 712 (1-2), 169-175. doi: 10.1016/S0378-4347(98)00146-7
Smith, GD and Smith, MT (1998). The excitatory behavioral and antianalgesic pharmacology of normorphine-3-glucuronide after intracerebroventricular administration to rats. Journal of Pharmacology And Experimental Therapeutics, 285 (3), 1157-1162.
Smith, GD, Prankerd, RJ and Smith, MT (1997). Biochemical synthesis, purification and preliminary pharmacological evaluation of normorphine-3-glucuronide. Life Sciences, 61 (2), 95-104. doi: 10.1016/S0024-3205(97)00364-0
Cabot, PJ, Cramond, T and Smith, MT (1997). Morphine has a dual concentration-dependent effect on K+-evoked substance P release from rat peripheral airways. Pulmonary Pharmacology & Therapeutics, 10 (4), 215-221. doi: 10.1006/pupt.1997.0094
The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated
Ross, FB and Smith, MT (1997). The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated. Pain, 73 (2), 151-157. doi: 10.1016/S0304-3959(97)00093-6
Quantitative autoradiography of peripheral opioid binding sites in rat lung
Cabot, PJ, Cramond, T and Smith, MT (1996). Quantitative autoradiography of peripheral opioid binding sites in rat lung. European Journal of Pharmacology, 310 (1), 47-53. doi: 10.1016/0014-2999(96)00363-9
Bartlett, SE and Smith, MT (1995). Effects of morphine-3-glucuronide and morphine on the K+-evoked release of [H-3]-glutamic acid and [C-14]-gamma-aminobutyric acid from rat brain synaptosomes. Life Sciences, 58 (5), 447-454. doi: 10.1016/0024-3205(95)02310-0
E. Bartlett, S and T. Smith, M (1995). the apparent affinity of morphine-3-glucuronide at μ1-opioid receptors results from morphine contamination: demonstration using HPLC and radioligand binding. Life Sciences, 57 (6), 609-615. doi: 10.1016/0024-3205(95)00311-S
Bartlett, SE and Smith, MT (1995). The Apparent Affinity of Morphine-3-Glucuronide At Mu(1)-Opioid Receptors Results From Morphine Contamination - Demonstration Using Hplc and Radioligand Binding. Life Sciences, 57 (6), 609-615.
Smith G.D. and Smith M.T. (1995). Morphine-3-glucuronide: evidence to support its putative role in the development of tolerance to the antinociceptive effects of morphine in the rat. Pain, 62 (1), 51-60. doi: 10.1016/0304-3959(94)00228-7
Leow, KP, Cramond, T and Smith, MT (1995). Pharmacokinetics and pharmacodynamics of oxycodone when given intravenously and rectally to adult patients with cancer pain. Anesthesia and Analgesia, 80 (2), 296-302. doi: 10.1097/00000539-199502000-00016
SMITH, M and CRAMOND, T (1994). UNTITLED - COMMENTS. Pain, 59 (1), 155-156. doi: 10.1016/0304-3959(94)90065-5
Bartlett, SE, Dodd, PR and Smith, MT (1994). Pharmacology of Morphine and Morphine-3-Glucuronide At Opioid, Excitatory Amino-Acid, Gaba and Glycine Binding-Sites. Pharmacology & Toxicology, 75 (2), 73-81. doi: 10.1111/j.1600-0773.1994.tb00327.x
Characterization of Nonconventional Opioid Binding-Sites in Rat and Human Lung
Cabot, PJ, Dodd, PR, Cramond, T and Smith, MT (1994). Characterization of Nonconventional Opioid Binding-Sites in Rat and Human Lung. European Journal of Pharmacology-Molecular Pharmacology Section, 268 (2), 247-255. doi: 10.1016/0922-4106(94)90195-3
Wright, Awe, Watt, JA, Kennedy, M, Cramond, T and Smith, MT (1994). Quantitation of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide in Plasma and Cerebrospinal-Fluid Using Solid-Phase Extraction and High-Performance Liquid-Chromatography with Electrochemical Detection. Therapeutic Drug Monitoring, 16 (2), 200-208. doi: 10.1097/00007691-199404000-00016
Leow, KP and Smith, MT (1994). The Antinociceptive Potencies of Oxycodone, Noroxycodone and Morphine After Intracerebroventricular Administration to Rats. Life Sciences, 54 (17), 1229-1236. doi: 10.1016/0024-3205(94)00849-3
Leow, K P and Smith, M T (1994). The antinociceptive potencies of oxycodone, noroxycodone and morphine after intracerebroventricular administration to rats. Life sciences, 54 (17), 1229-36.
Bartlett, SE, Cramond, T and Smith, MT (1994). The excitatory effects of morphine-3-glucuronide are attenuated by LY274614, a competitive NMDA receptor antagonist, and by midazolam, an agonist at the benzodiazepine site on the GABAA receptor complex. Life Sciences, 54 (10), 687-694. doi: 10.1016/0024-3205(94)00552-4
Determination of the Serum-Protein Binding of Oxycodone and Morphine Using Ultrafiltration
Leow, KP, Wright, Awe, Cramond, T and Smith, MT (1993). Determination of the Serum-Protein Binding of Oxycodone and Morphine Using Ultrafiltration. Therapeutic Drug Monitoring, 15 (5), 440-447. doi: 10.1097/00007691-199310000-00014
Comparative Oxycodone Pharmacokinetics in Humans After Intravenous, Oral, and Rectal Administration
Leow, KP, Smith, MT, Watt, JA, Williams, BE and Cramond, T (1992). Comparative Oxycodone Pharmacokinetics in Humans After Intravenous, Oral, and Rectal Administration. Therapeutic Drug Monitoring, 14 (6), 479-484. doi: 10.1097/00007691-199212000-00008
Leow, KP, Smith, MT, Williams, B and Cramond, T (1992). Single-Dose and Steady-State Pharmacokinetics and Pharmacodynamics of Oxycodone in Patients with Cancer. Clinical Pharmacology & Therapeutics, 52 (5), 487-495. doi: 10.1038/clpt.1992.176
Comments on Gong et al., PAIN, 48 (1992) 249-255
Cramond, Tess, Smith, Maree T. and Watt, Julie A. (1992). Comments on Gong et al., PAIN, 48 (1992) 249-255. Pain, 51 (1), 124-125. doi: 10.1016/0304-3959(92)90022-4
Smith M.T., Watt J.A., Mapp G.P. and Cramond T. (1991). Quantitation of oxycodone in human plasma using high–performance liquid chromatography with electrochemical detection. Therapeutic Drug Monitoring, 13 (2), 126-130. doi: 10.1097/00007691-199103000-00007
Cheng W.S.C., Murphy T.L., Smith M.T., Cooksley W.G.E., Halliday J.W. and Powell L.W. (1990). Dose-dependent pharmacokinetics of caffeine in humans: Relevance as a test of quantitative liver function. Clinical Pharmacology and Therapeutics, 47 (4), 516-524. doi: 10.1038/clpt.1990.66
Morphine-3-glucuronide - a potent antagonist of morphine analgesia
Smith M.T., Watt J.A. and Cramond T. (1990). Morphine-3-glucuronide - a potent antagonist of morphine analgesia. Life Sciences, 47 (6), 579-585. doi: 10.1016/0024-3205(90)90619-3
Chalk, J.B., Patterson, M., Smith, M.T. and Eadie, M.J. (1986). Correlations between in vitro dissolution, in vivo bioavailability and hypoglycaemic effect of oral glibenclamide. European Journal of Clinical Pharmacology, 31 (2), 177-182. doi: 10.1007/BF00606655
Brandon R.A., Eadie M.J. and Smith M.T. (1985). A sensitive liquid chromatographic assay for plasma aspirin and salicylate concentrations after low doses of aspirin. Therapeutic Drug Monitoring, 7 (2), 216-221. doi: 10.1097/00007691-198506000-00014
Organ and tissue preservation for transplantation: Monitoring by 31P nuclear magnetic resonance
Marshall V., Ross B., Smith M., Bartlett S. and Freeman D. (1985). Organ and tissue preservation for transplantation: Monitoring by 31P nuclear magnetic resonance. Transplantation Proceedings, 17 (2), 1693-1696.
Bioavailability and pharmacokinetics of phenytoin during pregnancy
Lander C.M., Smith M.T., Chalk J.B., de Wytt C., Symoniw P., Livingstone I. and Eadie M.J. (1984). Bioavailability and pharmacokinetics of phenytoin during pregnancy. European Journal of Clinical Pharmacology, 27 (1), 105-110. doi: 10.1007/BF00553163
Pharmacokinetics of midazolam in the aged
Smith M.T., Heazlewood V., Eadie M.J., Brophy T.O. and Tyrer J.H. (1984). Pharmacokinetics of midazolam in the aged. European Journal of Clinical Pharmacology, 26 (3), 381-388. doi: 10.1007/BF00548771
Chronic propranolol administration during pregnancy - Maternal pharmacokinetics
Smith, MT, Livingstone, I, Eadie, MJ, Hooper, WD and Triggs, EJ (1983). Chronic propranolol administration during pregnancy - Maternal pharmacokinetics. European Journal of Clinical Pharmacology, 25 (4), 481-490. doi: 10.1007/BF00542115
Metabolism of propranolol in the human maternal-placental-foetal unit
Smith, MT, Livingstone, I, Eadie, MJ, Hooper, WD and Triggs, EJ (1983). Metabolism of propranolol in the human maternal-placental-foetal unit. European Journal of Clinical Pharmacology, 24 (6), 727-732. doi: 10.1007/BF00607078
Propranolol in pregnancy three year prospective study
Livingstone I., Craswell P.W., Bevan E.B., Smith M.T. and Eadie M.J. (1983). Propranolol in pregnancy three year prospective study. Hypertension in Pregnancy, B2 (2), 341-350. doi: 10.3109/10641958309006092
Propranolol, Propranolol Glucuronide, and Naphthoxylactic Acid in Breast-Milk and Plasma
Smith, MT, Livingstone, I, Hooper, WD, Eadie, MJ and Triggs, EJ (1983). Propranolol, Propranolol Glucuronide, and Naphthoxylactic Acid in Breast-Milk and Plasma. Therapeutic Drug Monitoring, 5 (1), 87-93. doi: 10.1097/00007691-198303000-00008
Novel Source of Ubiquitous Phthalates as Analytical Contaminant
Hooper, WD and Smith, MT (1981). Novel Source of Ubiquitous Phthalates as Analytical Contaminant. Journal of Pharmaceutical Sciences, 70 (3), 346-347. doi: 10.1002/jps.2600700337
The pharmacokinetics of midazolam in man
Smith, MT, Eadie, MJ and Brophy, TO (1981). The pharmacokinetics of midazolam in man. European Journal of Clinical Pharmacology, 19 (4), 271-278. doi: 10.1007/BF00562804
The unsteady model - An alternative approach to nonlinear pharmacokinetics
Smith M.T. and Smith T.C. (1981). The unsteady model - An alternative approach to nonlinear pharmacokinetics. European Journal of Clinical Pharmacology, 20 (5), 387-398. doi: 10.1007/BF00615410
The pharmacokinetics of midazolam in man
Smith, M. T., Eadie, M. J., O'Rourke-Brophy, T. and Smith, T. C. (1980). The pharmacokinetics of midazolam in man. Clinical and Experimental Pharmacology and Physiology, 7 (6)
Pharmacokinetics of prazepam in man
Smith, MT, Evans, Lej, Eadie, MJ and Tyrer, JH (1979). Pharmacokinetics of prazepam in man. European Journal of Clinical Pharmacology, 16 (2), 141-147. doi: 10.1007/BF00563121
In vivo biodistribution of the nitric oxide donor, PRG150, using PET imaging in rats
Pippin, Adam, Voll, Ronald, Liotta, Dennis, Smith, Maree and Goodman, Mark (2016). In vivo biodistribution of the nitric oxide donor, PRG150, using PET imaging in rats. RESTON: SOC NUCLEAR MEDICINE INC.
Smith, Maree, Muralidharan, Arjun and Praveen, Anand (2014). Analgesic efficacy and mode of action of small molecule Angiotensin II type 2 receptor (AT2R) antagonists for neuropathic and inflammatory pain. 34 th Annual Scientific Meeting of the Australian Pain Society, Hobart , Australia, 13 - 16 April 2014.
Ghassabian, Sussan, Rethwan, Ahmad, Griffiths, Lyn and Smith, Maree (2014). Development and validation of an lc-ms/ms bioanalytical method for quantification of homocysteine (hcy) in samples of human serum. International Pharmaceutical Federation (FIP), Melbourme, Australia, 13-16 April 2014.
Establishment of a rat model of low back pain
Muralidharan, Arjun and Smith, Maree (2014). Establishment of a rat model of low back pain. 15th World Congress on Pain, Buenos Aires, Argentina, 6 - 11 October 2014.
Shekar, K., Diab, S., McDonald, C., Fisquet, S., Dunster, K., Fung, L., Platts, D., Ghassabian, S., Barnett, A., Roberts, J., Smith, M. and Fraser, J. (2012). Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation may cause therapeutic failure. Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Brisbane, QLD, Australia, 16-19 August 2012. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2012.05.581
Shekar, K., Mcdonald, C., Fisquet, S., Barnett, A., Ghassabian, S., Fung, L., Roberts, J., Smith, M. and Fraser, J. (2012). Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation may cause therapeutic failure. Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meetin, Brisbane, QLD Australia, 16-19 August 2012. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2012.05.584
Shekar, K., Mcdonald, C., Fisquet, S., Barnett, A., Ghassabian, S., Fung, L., Roberts, J., Smith, M. and Fraser, J. (2012). Is morphine superior to fentanyl for analgesia during extracorporeal membrane oxygenation in adult patients?. Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Brisbane, QLD Australia, 16-19 August 2012. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2012.05.585
Edwards, Stephen R., Coulson, Elizabeth J. and Smith, Maree T. (2010). A behavioural study assessing memory deficits in the APP/PS1 double transgenic mouse model of Alzheimer’s disease using the Morris water maze.. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) 44th Annual Scientific Meeting 2010, Melbourne, Australia, 28 November-1 December 2010. Melbourne, Australia: ASCEPT.
Edwards, Stephen and Smith, M.T. (2009). A study of the application of the Morris water maze to the establishment of a preclinical model of Alzheimer's disease in the rat. ASCEPT 43rd Annual Scientific Meeting 2009: The Rights of Medicines, Darling Harbour, NSW, Australia, 29 November-2 December 2009.
Martin, W., Lewis, R. J., Palant, E., Brust, A., Colless, B., Schmidt, P., Drinkwater, R., Stearns, L. J., Cousins, M., Gouke, R., Hughes, D., Rauck, R., Day, D., Nielsen, C. K. and Smith, M. T. (2009). DEVELOPMENT OF XEN2174: NON-CLINICAL STUDIES AND AN OPEN-LABEL I/IIa STUDY OF INTRATHECAL USE IN ONCOLOGY PATIENTS WITH MODERATE TO SEVERE PAIN. 21st American Peptide Symposium, Bloomington in, Jun 07-12, 2009. HOBOKEN: JOHN WILEY & SONS INC.
Brust, A., Colless, B., Cousins, M., Day, D., Drinkwater, R., Gouke, R., Hughes, D., Lewis, R. J., Martin, W., Nielson, C., Palant, E., Rauck, R., Schmidt, P., Smith, M. T. and Steams, L. J. (2009). Development of XEN2174 and an escalating safety and tolerability study of intrathecal use in oncology patients. Michal Lebl Peptides Breaking Away, Bloomington, Indiana, U.S.A., 7-12 June, 2009. San Diego, C.A. U.S.A.: American Peptide Society.
High-quality, cost-effective preclinical product development solutions
Smith, Maree (2009). High-quality, cost-effective preclinical product development solutions. BIO Korea 2009, Seoul, Korea, 16-18 September 2009. Seoul, Korea: BIO Korea 2009.
Kuo, A., Hemstapat, K., Wyse, B. D., South, S. M. and Smith, M. T. (2008). Comparative profiles of the antinociceptive and constipating effects of single intracerebroventricular (i.c.v.) bolus doses of morphine and oxycodone in rats. 12th World Congress on Pain, Glasgow, UK, 17-22 August 2008.
Hemstapat, K., Kuo, A., Smith, M.T. and Wyse, B.D. (2008). Comparative profiles of the antinociceptive and constipating effects of single intracerebroventricular (i.c.v.) bolus doses of morphine, morphine-6-glucuronide and fentanyl in rats Kuo A, Hemstapat K, Wyse BD, Smith MT. 4th Scientific Meeting of the Australian Health and Medical Research Congress, Brisbane, Australia, 16 - 21 November, 2008.
Lewis, R. J., Palant, E., Brust, A., Colless, B., Schmidt, P., Nielsen, C. K., Smith, M. T. and Drinkwater, R. (2008). Development of novel X-conopeptide inhibitors of the norepinephrine transporter with analgesic potential. 12th World Congress on Pain, Glasgow, Scotland, 17-22 August, 2008.
Zin, Che Suraya, Nissen, Lisa, Smith, Maree, O'Callaghan, James and Moore, Brendan (2008). Efficacy of Pregabalin And Oxycodone in patients with post-herpetic neuralgia or painful diabetic neuropathy. 28th Annual Scientific Meeting of the Australian Pain Society, Perth Western Australian, 30 March - 2 April 2008.
Otto, K., Wyse, B. D., South, S. M., Cabot, P. J. and Smith, M. T. (2008). Influence of diet on the longitudinal temporal development of opioid hyposensitivity and tactile allodynia in the Zucker Diabetic Fatty (ZDF) rat. 12th World Congress on Pain, Glasgow, Scotland, 17-22 August 2008.
Cabot, P.J., Otto, K., Smith, M.T., South, S.M. and Wyse, B.D. (2008). Influence of diet on the longitudinal temporal development of opioid hyposensitivity and tactile allodynia in the Zucker Diabetic Fatty (ZDF) rat. 28th Annual Scientific Meeting of the Australian Pain Society: The Spectrum of Pain, Perth, Australia, 30 March – 2 April, 2008.
Mechanistic insight into the anti-allodynic effects of PRG100
Huang, L., Smith, M. T. and Wyse, B. D. (2008). Mechanistic insight into the anti-allodynic effects of PRG100. 12th World Congress on Pain, Glasgow, Scotland, U. K., 17-22 August 2008. IASP Press.
Mechanistic insight into the anti-allodynic effects of PRG150
Huang, L., Wyse, B. D. and Smith, M. T. (2008). Mechanistic insight into the anti-allodynic effects of PRG150. 12th World Congress on Pain, Glasgow, Scotland, 17-22 August 2008.
Novel strategies in new opioid analgesic development
Smith, M. T. (2008). Novel strategies in new opioid analgesic development. Combined CME Spring Meeting of Faculty of Pain Medicine, ANZCA, Acute Pain special Interest Group of ANZCA, ASA and NZSA, Acute Pain Special Interest Group of IASP, Ayers Rock, Northern Territory, Australia, 18-20 September 2008.
Opioid-induced hyperalgesia, opioid rotation and opioid combinations
Smith, Maree T. (2008). Opioid-induced hyperalgesia, opioid rotation and opioid combinations. Combined CME Spring Meeting of Faculty of Pain Medicine, ANZCA, Acute Pain special Interest Group of ANZCA, ASA and NZSA, Acute Pain Special Interest Group of IASP: Pain at the Centre, Ayers Rock, Australia, 18-20 September 2008.
Preclinical development of new drugs for pain treatment
Smith, M. T. (2008). Preclinical development of new drugs for pain treatment. 4th Australian Health and Medical Research Congress, Brisbane, Australia, 16-21 November 2008. Brisbane, Australia:
Taking the pain out of research
Smith, M. T., Williamson, O. and Farrell, M. (2008). Taking the pain out of research. 28th Annual Scientific Meeting of the Australian Pain Society, Perth, Australia, 30 March - 2 April, 2008.
Moore, B. J., Zin, C. S., Nissen, L. M., O'Callaghan, J. P. and Smith, M. T. (2008). Treating post-herpetic neuralgia or painful diabetic neuropathy with a combination of pregabalin and oxycodone: A randomized controlled trial. 12th World Congress on Pain, Glasgow, Scotland, 17-22 August, 2008.
2',3'-Dideoxycytidine-Induced Neuropathy: Comparison With Other Neuropathic Pain Models
Wyse, B., Rogers, H., O'Hagan, S., Dao, C. B., Weerasinghe, G., Smith, M. T. and South, S. M. (2007). 2',3'-Dideoxycytidine-Induced Neuropathy: Comparison With Other Neuropathic Pain Models. 41st Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists, Adelaide South Australia, 2-6 December 2007.
Moore, B. J., Nissen, L. M., O'Callaghan, J. P., Smith, M. T. and Zin, C. S. (2007). A randomized control trial of pregabalin and oxycodone in post herpetic neuralgia and painful diabetic neuropathy. 41st Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and 10th Southeast Asian SEAWP-RMP Joint meeting 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists with HBPRCA, Adelaide, South Australia, 2 - 6 December, 2007. Victoria, Australia: ASCEPT.
Additive Antinociception Following Co-administration of a NR2B-Selective NMDA Antagonist with BDNF
South, S. M., Dao, C. B., Wyse, B. and Smith, M. T. (2007). Additive Antinociception Following Co-administration of a NR2B-Selective NMDA Antagonist with BDNF. 41st Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists, Adelaide, South Australia, 2-6 December 2007.
Zin, Che Surava, Smith, Maree, Moore, Brendan, O'Callaghan, James and Nissen, Lisa (2007). Co-administration of pregabalin and oxycodone for the treatment of neuropathic pain: A randomized double-blind, placebo-controlled, parallel-group study. Annual Conference of the Australasian Pharmaceutical Science Association, Sydney, 8-11 December 2007.
Cabot, P. J., Otto, K. J., Smith, M. T., South, S. M. and Wyse, B. D. (2007). Influence of diet on the temporal development of tactile allodynia and opioid hyposensitivity for 22-wks in the Zucker Diabetic Fatty (ZDF) rat. Second International Congress on Neuropathic Pain, Berlin, Germany, 7- 10 June 2007. Berlin, Germany: doi: 10.1016/j.ejpain.2007.03.177
Modelling Parkinson's Disease in rats
Smith, M. T., Wyse, B., Hall, H., Moisan, A., LeMontagne, S., Wolliez, A., Weerasinghe, G. and South, S. M. (2007). Modelling Parkinson's Disease in rats. 41st Annual Scientific Meeting of Australian Society of Clinical and Experimental Pharmacologists and Toxicologists & South-East Asian Western Pacific Regional Meeting of Pharmacologists, Adelaide, Australia, 2-6 December 2007.
Patel, A., South, S. M., Smith, M. T. and Cabot, P. J. (2007). Possible mechanism of action for neuroprotective effect of fucoidin in A-beta-induced Alzheimer's disease model. Neuroscience 2007, San Diego, U.S., 3-7 November, 2007. Society for Neuroscience.
Smith, M. T. (2007). The APS/APRA PhD Scholarship Scheme: Basic and clinical science research targeted to improving patient outcomes. 27th Annual Scientific Meeting of the Australian Pain Society (IASP Chapter): The Torture of Pain: Crossing cultural barriers in Australia, Asia and beyond, Adelaide, Australia, 1-4 April 2007.
(PK)PD of the anti-allodynic effects of gabapentin and oxycodone in a neuropathic pain rodent model
Tan, S., Duffull, S B and Smith, M T (2006). (PK)PD of the anti-allodynic effects of gabapentin and oxycodone in a neuropathic pain rodent model. PAGANZ 06, Auckland, New Zealand / School of Medicine, 7-9 Feburary, 2006. New Zealand: Population Approach Group in Australia and New Zealand.
Assessment of fucoidin efficacy in a beta-peptide induced in Alzheimer's disease model
Patel, A., Smith, M. T., South, S. M. and Cabot, P. J. (2006). Assessment of fucoidin efficacy in a beta-peptide induced in Alzheimer's disease model. Neuroscience 2006, Atlanta, Geogia / Georgia World Congress Center, 14-18 October 2006. USA: Society for Neuroscience.
Combining opioids - Preclinical and clinical studies
Smith, M. T. (2006). Combining opioids - Preclinical and clinical studies. 7th Biennial Conference of the Australian and New Zealand Society of Palliative Medicine, Newcastle, 4-6 October 2006. Newcastle: Australian and New Zealand Society of Palliative Medicine.
Otto, K. J., Wyse, B. D., Cabot, P. J. and Smith, M. T. (2006). Insulin implants prevent the temporal development of tactile allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats. 26th Annual Scientific Meeting of the Australian Pain Society, Melbourne / Grand Hyatt Hotel, 9-12 April 2006. Melbourne: Australian Pain Society.
PRG100, a novel anti-allodynic agent
Tsui, D. Y. Y., Wyse, B. D., Monteith, G. R. and Smith, M. T. (2006). PRG100, a novel anti-allodynic agent. 26th Annual Scientific Meeting of the Australian Pain Society, Melbourne, Australia, 9-12 April, 2006. Victoria, Australia: Australian Pain Society.
Tsui, D. Y., Monteith, G. R., Wyse, B. D. and Smith, M. T. (2006). Preliminary evaluation of cultured embryonic rat midbrain neurons as an in vitro model of diabetic neuropathy. 11th World Congress on Pain, Sydney, Australia, 21-26 August 2005. Seattle, Wa.: IASP Press.
Ko, E., Cramond, T R O, Smith, M T and Cabot, P J (2006). Retrospective drug utilisation evaluation of gabapentin for the treatment of neuropathic pain by the Multidiscplinary Pain Centre, Royal Brisbane and Women's Hospital. 2006 Conference of the Queensland Branch of the Society for Hospital Pharmacists of Australia, Carlton Crest / Brisbane, October 2006.
The novel compound PRG100 reverses tactile allodynia in STZ-induced diabetic rats
Tsui, D. Y. Y., Wyse, B D and Smith, M T (2006). The novel compound PRG100 reverses tactile allodynia in STZ-induced diabetic rats. 2006 Neuroscience Meeting, Atlanta, 14-18 October, 2006. Atlanta: Society for Neuroscience.
Smith, M. T. (2006). Update on opioids receptors. 7th Biennial Conference of the Australian and New Zealand Society of Palliative Medicine, Newcastle, 4-6 October 2006. Newcastle: Australian and New Zealand Society of Palliative Medicine.
Edwards, S. R., Mather, L. E. and Smith, M. T. (2005). Antihyperalgesic and anti-inflammatory effects of RS- & S-ketamine in freunds complete adjuvant (FCA)-induced inflammation. 11th World Congress on Pain, Sydney, 21-26 August 2005. USA: IASP Press.
Assessment of fucoidin efficacy in Ab-peptide induced Alzheimer's disease model
Patel, A., Smith, M. T., South, S. M. and Cabot, P. J. (2005). Assessment of fucoidin efficacy in Ab-peptide induced Alzheimer's disease model. Joint Meeting of ASCEPT and APSA, Melbourne, 4-7 December 2005. Australia: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists.
Lotfipour, S., Ross, F. B., Brown, L. C. and Smith, M. T. (2005). Chronic administration of dietary L-Arginine reverses opioid hyposensitivity for the relief of tactile allodynia in a rat model of diabetic neuropathy. 11th World Congress on Pain, Sydney, 21-26 August 2005. USA: IASP Press.
In vivo proof-of-concept study: Commercialisation and regulatory imperatives
Smith, M. T. (2005). In vivo proof-of-concept study: Commercialisation and regulatory imperatives. Joint Meeting of ASCEPT and APSA, Melbourne, 4-7 December 2005. Australia: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists.
Otto, K. J., Wyse, B. D., Cabot, P. J. and Smith, M. T. (2005). Insulin implants prevent the temporal development of tactile allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic Wistar rats. 11th World Congress on Pain, Sydney, 21-26 Aug. 2005. USA: IASP Press.
Smith, M. T., Nielsen, C. K., Hwang, J. C., Kydd, S., Wyse, B. D., Lewis, R. J. and Drinkwater, R. D. (2005). Intrathecal XEN2174 produces significant anti-allodynia in morphine-tolerant rats using the CCI-model of persistent neuropathic pain. 11th World Congress on Pain, Sydney, Australia, 21-26 August 2005. Seattle, Wa.: IASP Press.
Tan, S., Wyse, B. D., Duffull, S. B. and Smith, M. T. (2005). Investigation of temporal changes in the anti-allodynic effectiveness of chronically administered gabapentin in a rat model of neuropathic pain. 11th World Congress on Pain, Sydney, 21-26 August 2005. USA: IASP Press.
Wyse, B. D., Hwang, J. C., Kydd, S., Patterson, M., Nielsen, C. K., Belyea, C., McIntosh, D. and Smith, M. T. (2005). Investigation of the anti-allodynic and anti-hyperalgesics effects of ACV1 in a rat model of neuropathic pain. 11th World Congress on Pain, Sydney, Australia, 21-26 August 2005. Seattle, Wa.: IASP Press.
Smith, M. T. (2005). Pain and its treatment. 6th Australian Peptide Conference, Hamilton Island, Australia, 9-15 October, 2005.
What you and your patient need to know about opioids
Smith, M. T., Moore, B. and Molloy, A. (2005). What you and your patient need to know about opioids. Partners in Pain: Patients, Clinicians and Pain Management, Sydney, Australia, 18-19 August, 2005.
Anti-allodynic effects of Xen2174 in rats with neuropathy. Abstract
Smith, M. T., Nielsen, C., Lewis, R., Alewood, D. and Drinkwater, R. D. (2004). Anti-allodynic effects of Xen2174 in rats with neuropathy. Abstract. ANZCA Annual Scientific Meeting, Perth, Western Australia, 1-5 May, 2004. Australia: ANZCA.
Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain
Nielsen, C., Smith, M. T., Lewis, R., Alewood, D. and Drinkwater, R. D. (2004). Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. CPT2004: 8th World Congress on Clinical Pharmacology & Therapeutics, Brisbane, Qld, Australia, 1-6 August, 2004. Oxford, United Kingdom: Blackwell Scientific Publications. doi: 10.1111/j.1440-1681.2004.cep_4027.pdf.x
Patel, A., Smith, M. T. and Cabot, P. J. (2004). Assessment of working spatial memory utilising T-maze and Morris water-maze for the study of a rodent model of alzheimer's disease. 4th Annual Queensland Health and Medical Scientific Meeting, Brisbane, 30 November - 1 December 2004. Brisbane: Qld Government.
Huang, L., Edwards, S. R. and Smith, M. T. (2004). Comparative pharmacokinetics and metabolism of subcutaneous oxycodone in male dark agouti relative to sprague-dawley rats. CTP 2004, Brisbane, 1-6 August 2004. Australia: Blackwell Publishing Asia.
Edwards, S. R. and Smith, M. T. (2004). Determination of morphine, oxycodone, morphine-3-glucuronide, & noroxycodone concentrations in rat serum by liquid chromatography (LC) - electrospray mass spectrometry (EMS). CPT2004, Brisbane, 1-6 August 2004. Australia: Blackwell Publishing.
Effect of insulin treatment on diabetic characteristics in the STZ-diabetic rat
Otto, K. J., Wyse, B. D., Cabot, P. J. and Smith, M. T. (2004). Effect of insulin treatment on diabetic characteristics in the STZ-diabetic rat. 4th Annual Queensland Health and Medical Scientific Meeting, Brisbane, 30 Nov - 1 Dec 2004. Brisbane: Qld Government.
Tsui, D. Y., Hawes, S., Patterson, M. and Smith, M. T. (2004). Longitudinal investigation of the antinociceptive potency of oxycodone and morphine in the zucker rat. Clinical Pharmacology and Therapeutics 2004, Brisbane, 1-6 August, 2004. Australia: Blackwell Publishing.
Opioid rotation and methadone: Pharmacokinetic considerations
Smith, M. T., Fleming, J. A. and Connor, M. (2004). Opioid rotation and methadone: Pharmacokinetic considerations. 2004 ANZCA Annual Scientific Meeting, Perth, Western Australia, 1-5 May, 2004. Melbourne, Vic, Australia: Australian and New Zealand College of Anaesthetists (ANZCA).
Opioids and NMDA receptors: Neuro-excitation and abnormal pain behaviours
Smith, M. T. (2004). Opioids and NMDA receptors: Neuro-excitation and abnormal pain behaviours. ANZCA Annual Scientific Meeting, Perth, 1-5 May 2004. Australia: ANZCA.
Oxycodone: A dose ranging pharmacodynamic study in dogs
Bubb, L. M., Keates, H. L. and Smith, M. T. (2004). Oxycodone: A dose ranging pharmacodynamic study in dogs. Proc. of Assoc. of Veterinary Anaesthetists, Vienna, Austria, 16-17 September 2004. Austria:
Oxycodone: A dose ranging pharmacodynamic study in dogs
Bubb, L. M., Keates, H. L. and Smith, M. T. (2004). Oxycodone: A dose ranging pharmacodynamic study in dogs. Showcasing Faculty research through our postgraduates, Gatton, 5th November 2004. Gatton: NRAVS Faculty.
Tsui, D.Y., Hawes, S., Patterson, M. and Smith, M. T. (2004). P2.3 longitudinal investigation of the comparative anti-allodynic potencies of oxycodone and morphine in the zucker rat relative to the streptozotocin-induced diabetic rat. 25th Annual Scientific Meeting of the Australian Pain Society, Canberra, 7-10 March 2004. Australia: Australian Pain Society.
The pro-allodynic effects of morphine-3-glucuronide (M3G) appear to be opioid-receptor mediated
Nielsen, C., De Cruz, S. E. and Smith, M. T. (2004). The pro-allodynic effects of morphine-3-glucuronide (M3G) appear to be opioid-receptor mediated. 25th Annual Scientific Meeting of the Australian Pain Society, Canberra, 7-10 March 2004. Australia: Australian Pain Society.
The pro-allodynic effects of morphine-3-glucuronide (M3G) in the rat
Smith, M. T., Le, L., Hemstapat, K., De Cruz, S. E. and Nielsen, C. (2004). The pro-allodynic effects of morphine-3-glucuronide (M3G) in the rat. CTP 2004, Brisbane, 1-6 Aug 2004. Australia: Blackwell Publishing Asia.
A fresh approach to neuropathic pain management: From the animal model to the patient
Moore, B., Azzopardi, J., Cabot, P. J., Gray, P., Roufogalis, B. and Smith, M. T. (2003). A fresh approach to neuropathic pain management: From the animal model to the patient. Combined meeting of the Australian Pain Society 24th ASM and New Zealand Pain Society 10th ASM, Christchurch, NZ, 9-13 March 2003. Sydney: Australian Pain Society.
Tsui, D. Y., Hawes, S., Patterson, M. and Smith, M. T. (2003). Longitudinal investigation of the antinociceptive potency of oxycodone and morphine in the Zucker rat. Annual Scientific Meeting of Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists 2003, Sydney, 30 November - 3 December 2003. Melbourne: ASCEPT.
Edwards, S. R. and Smith, M. T. (2003). Quantification of morphine, oxycodone, morphine-3-glucuronide and noroxycodone in rat serum by high performance liquid chromatography (HPLC-electrospray mass spectrometry (EMS). Annual Scientific Meeting of ASCEPT 2003, Sydney, 30 November - 3 December 2003. Melbourne: ASCEPT.
Huang, L., Le, L., Edwards, S. R. and Smith, M. T. (2003). Serum concentrations of metabolically-derived oxymorphone are insignificant in diabetic and non-diabetic adult male Dark Agouti rats following subcutaneous oxycodone bolus administration: Comparison with Sprague-Dawley rats. Annual Scientific Meeting of ASCEPT, Sydney, 30 November - 3 December 2003. Melbourne: ASCEPT.
Anti-allodynic efficacy of the conopeptide, MR1A, in rats with neuropathic pain
Nielsen, C., Ross, F. B., Lewis, R. J., Drinkwater, R. D. and Smith, M. T. (2002). Anti-allodynic efficacy of the conopeptide, MR1A, in rats with neuropathic pain. 10th World Congress on Pain, San Diego, 17-22 Aug. 2002. Seattle: IASP Press.
Anti-allodynic efficacy of the x-conipeptide, MR1A, in rats with neuropathic pain
Nielsen, C., Ross, F. B., Lewis, R. J., Drinkwater, R. D. and Smith, M. T. (2002). Anti-allodynic efficacy of the x-conipeptide, MR1A, in rats with neuropathic pain. AHMR Congress 2002, Melbourne, 24-29 Nov. 2002. Melbourne: NHMRC.
Wells, J. A., Punjanon, T. and Smith, M. T. (2002). Electrolyte removal from artificial CSF by HPLC to restore ESI-MS/MS signal intensity in quantification of morphine and its glucuronide metabolites. 10th World Congress on Pain, San Diego, 17-22 Aug. 2002. Seattle: IASP Press.
Le, L., Hemstapat, K. and Smith, M. T. (2002). In vivo investigation of the effects of intracerebroventricular (ICV) morphine-3-glucuronide (M3G) on von frey paw withdrawal thresholds in rats. AHMR Congress 2002, Melbourne, 24-29 Nov. 2002. Melbourne: NHMRC.
Hemstapat, K., Monteith, G. R. and Smith, M. T. (2002). Investigation of the role of dynorphin-A in mediating morphine-3-glucuronide's neuro-excitatory effects. 10th World Congress on Pain, San Diego, 17-22 Aug. 2002. Seattle: IASP Press.
Lotfipour, S., Ross, F. B., Saini, K. and Smith, M. T. (2002). Oxycodone, but not morphine, is efficacious for the relief of tactile allodynia in diabetic rats at three and six months after the induction of diabetes with streptozotocin. 10th World Congress on Pain, San Diego, 17-22 Aug. 2002. Seattle: IASP Press.
Hemstapat, K., Monteith, G. R. and Smith, M. T. (2002). P/Q and L-type calcium channel blockers abolish morphine-3-glucuronide (M3G)-induced indirect activation of the NMDA receptor. AHMR Congress 2002, Melbourne, 24-29 Nov. 2002. Melbourne: NHMRC.
Mather, L. E., Punjanon, T. and Smith, M. T. (2002). Prolonged oestradiol supplementation does not significantly alter levels of antinociception evoked by ICV morphine in adult male rats. 10th World Congress on Pain, San Diego, 17-22 Aug. 2002. Seattle: IASP Press.
Le, L., Chmura, P., Mather, L. E. and Smith, M. T. (2002). Serum 17 -oestradiol concentrations are directly correlated with the time to reach peak antinociception in oestradiol-pretreated rats administered prolonged intravenous morphine infusions. 10th World Congress on Pain, San Diego, 17-22 Aug. 2002. Seattle: IASP Press.
Smith, M. T., Patterson, M. and Ross, F. B. (2002). Supraspinally administered oxycodone has intrinsic anti-allodynic effects for the alleviation of tactile allodynia in adult male rats with streptozotocin-induced diabetes. 10th World Congress on Pain, San Diego, 17-22 August 2002. Seattle: IASP Press.
Patterson, M., Ross, F. B. and Smith, M. T. (2001). Differential changes in the potency of supraspinally administered oxycodone relative to morphine for the alleviation of tactile allodynia in adult male Dark Agouti rats with streptozotocin-induced diabetes. ASCEPT Annual Scientific Meeting, Dunedin, New Zealand, 3 - 5 December, 2001. Melbourne, Vic: ASCEPT Press.
Wells, J. A., Punjanon, T., Wright, A. W. and Smith, M. T. (2001). Electrolyte removal is essential for optimizing ESI-MS/MS signal intensity for the quantification of morphine and morphine-3-glucuronide in samples of rat brain microdialysate. Annual Scientific Meeting of ASCEPT 2001, Dunedin, New Zealand, 3 - 5 December, 2001. Melbourne, Vic: ASCEPT Press.
Evaluation of the neurotoxic effects of morphine-3-glucuronide (M3G) in neuronal cultures.
Hemstapat, K., Smith, S. A., Monteith, G. R. and Smith, M. T. (2001). Evaluation of the neurotoxic effects of morphine-3-glucuronide (M3G) in neuronal cultures.. Annual Conference of APSA, Melbourne, 24-27 Nov 2001. Melbourne: APSA.
Nissen, L., Mattiazzi, A., Smith, M. T., Moore, B., Williams, B. and Cramond, T. R. (2001). Follow-up audit of analgesic prescribing and use at the Multidisciplinary Pain Centre at Royal Brisbane Hospital: Temporal changes in anticonvulsant prescribing from 1999 to 2000. 22nd Annual Scientific Meeting of Australian Pain Society 2001, Cairns, Qld, 8 - 12 April, 2001. Melbourne: Australian Pain Society.
Heterodimeric opioid receptors: Implications for practice?
Smith, M. T. (2001). Heterodimeric opioid receptors: Implications for practice?. From Science to Practice, 22nd Annual Scientific Meeting of Australian Pain Society, Cairns, Qld, 8-12 Apr 2001. Australian Pain Society.
Heterodimeric opioid receptors: Novel targets for a new generation of opioid analgesics.
Smith, M. T. (2001). Heterodimeric opioid receptors: Novel targets for a new generation of opioid analgesics.. IUPS Satellite Symposium on Pain Mechanisms, The Australian Museum, Sydney, 19-22 Aug 2001. Sydney, Aust.: International Union of Physiological Sciences.
Ross, F. B., Saini, K. and Smith, M. T. (2001). Increased potency of single doses of subcutaneous oxycodone, but not morphine, in Dark Agouti rats with a chronic constriction injury (CCI) of the sciatic nerve relative to control rats.. 22nd Annual Scientific Meeting of Australian Pain Society, Cairns, Qld, 8-12 April 2001. Melbourne: Australian Pain Society.
Le, L., Chmura, P., Mather, L. E. and Smith, M. T. (2001). Influence of oestradiol pretreatment of adult male rats on levels of antinociception evoked by chronically infused intravenous morphine. Annual Scientific Meeting of ASCEPT, Dunedin, New Zealand, 3 - 5 December, 2001. Melbourne, Vic: ASCEPT Press.
Hemstapat, K., Monteith, G. R. and Smith, M. T. (2001). M3G's neuro-excitatory side-effects are mediated pre-synaptically: Mechanistic studies implicating dynorphin A.. Annual Scientific Meeting of ASCEPT 2001, Dunedin, New Zealand, 3 - 5 December, 2001. Melbourne, Vic: ASCEPT Press.
Oxycodone has a distinctly different pharmacology from morphine
Smith, Maree T., Ross, Fraser B., Nielsen, Carsten K. and Saini, Kamal (2001). Oxycodone has a distinctly different pharmacology from morphine. 2nd Asian-Pacific Symposium on Pain Control, Sydney, Australia, 26-28 January, 2001. London, UK: W.B. Saunders. doi: 10.1053/eujp.2001.0301
Hemstapat, K., Monteith, G. R. and Smith, M. T. (2001). Pharmacological studies to define the mechanism mediating the neuro-excitatory side-effects of morphine-3-glucuronide (M3G).. Australian Society for Medical Research 40th National Scientific Conference, 2001, Surfers Paradise, 24-27 Nov. 2001. Sydney, Aust.: Australian Society for Medical Research.
Nielsen, C., Smith, M. T. and Ross, F. B. (2001). Preliminery investigation of the ability of oxycodone to stimulate agonist-induced internalisation of the m-opioid receptor. Annual Scientific Meeting of ASCEPT, Dunedin, New Zealand, 3 - 5 December, 2001. Melbourne, Vic: ASCEPT Press.
Punjanon, T., Mather, L. E. and Smith, M. T. (2001). Prolonged oestradiol supplementation does not significantly alter levels of antinociception evoked by icv morphine in adult male rats. Annual Scientific Meeting of ASCEPT, Dunedin, New Zealand, 3 - 5 December, 2001. Melbourne, Vic: ASCEPT Press.
Smith, M. T., Ross, F. B., Lotfipour, S. and Saini, K. (2001). Temporal changes in the potency of subcutaneous oxycodone relative to morphine for the alleviation of tactile allodynia in Dark Agouti Rats with diabetes secondary to streptozotocin injection. Annual Scientific Meeting of ASCEPT, Dunedin, New Zealand, 3 - 5 December, 2001. Melbourne, Vic: ASCEPT Press.
Hemstapat, K., Smith, D., Monteith, G. R. and Smith, M. T. (2001). The neuro-excitatory effects of morphine-3-glucuronide (M3G): Studies of the possible role of non-NMDA mechanisms in cultured embryonic rat hippocampal neurones.. 22nd Annual Scientific Meeting of Australian Pain Society, Cairns, Qld, 8-12 April 2001. Melbourne: Australian Pain Society.
Nielsen, C., Ross, F. B. and Smith, M. T. (2000). Absence of antinociceptive cross-tolerance between supraspinal oxycodone and intravenous morphine in the dark agouti rat. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, Newcastle, Australia, 3-6 December, 2000. Melbourne, Vic.: Blackwell Scientific Publications.
Smith, M. T., Ross, F. B., Lewis, R., Kurek, J. and Cabot, P. J. (2000). Antinociceptive efficacy of intrathecal AM336 for the relief of adjuvant-induced chronic inflammatory pain in the rat hindpaw. Joint Meeting of ASCEPT and the British Pharmacological Society, Melbourne, Australia, 26 - 28 April, 2000. Melbourne, Vic.: Blackwell Scientific Publications.
Wright, A. W., Punjanon, T. and Smith, M. T. (2000). Determination of morphine, M3G, M6G, oxycodone and their N-demethylated metabolites in biological fluids, using HPLC-MS/MS. he Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, Newcastle, Australia, 3 - 6 December, 2000. Melbourne, Vic.: Blackwell Scientific Publications.
Ross, F. B., Saini, K. and Smith, M. T. (2000). Differential potency of subcutaneous morphine and oxycodone for the relief of mechanical allodynia in dark agouti rats with a chronic constriction injury (CCI) of the sciatic nerve. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, Newcastle, Australia, 3 - 6 December, 2000. Melbourne, Vic.: Blackwell Scientific Publications.
Hemstapat, K., Smith, D., Monteith, G. R. and Smith, M. T. (2000). Elucidation of the mechanism underlying the neuro-excitatory effects of morphine-3-glucoronide (M3G): Studies in rat embryonic hippocampal neurones. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, Newcastle, Australia, 3-6 December, 2000. Melbourne, Vic.: Blackwell Scientific Publications.
ICV hydromorphone-3-glucuronide (H3G) elicits neuro-excitation in the rat
Wright, A. W., Mather, L. E. and Smith, M. T. (2000). ICV hydromorphone-3-glucuronide (H3G) elicits neuro-excitation in the rat. Joint Meeting of ASCEPT and the British Pharmacological Society, Melbourne, Australia, 26 - 28 April, 2000. Melbourne, Vic.: Blackwell Scientific Publications.
Incomplete and assymetric antinociceptive cross-tolerance between oxycodone and morphine in the rat
Nielsen, C., Ross, F. B. and Smith, M. T. (2000). Incomplete and assymetric antinociceptive cross-tolerance between oxycodone and morphine in the rat. Joint Meeting of ASCEPT and the British Pharmacological Society, Melbourne, Australia, 26 - 28 April, 2000. Melbourne, Vic.: Blackwell Scientific Publications.
Smith, M. T., Ross, F. B., Lewis, R., Kurek, J. and Cabot, P. J. (2000). Lack of cross-tolerance between intrathecal AM336 and intravenous morphine in contrast to the marked cross-tolerance between ziconotide and morphine. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, Newcastle, Australia, 3 - 6 December, 2000. Melbourne, Vic.: Blackwell Scientific Publications.
Hemstapat, K., Monteith, G. R. and Smith, M. T. (2000). Morphine-3-glucuronide (M3G) evoked increases in [Ca2+]cyt oscillations in cultured rat embryonic hippocampal neurones. Australasian Pharmaceutical Science Association 2000 Annual Conference, Newcastle, Australia, 6 - 8 December, 2000. University of Qld: Australasian Pharmaceutical Science Association.
Hemstapat, K., Monteith, G. R. and Smith, M. T. (2000). Spontaneous oscillations in neuronal cytosolic free Ca2+ ([Ca2+]cyt ) in rat cultured embryonic hippocampal neurons maintained in serum-free neurobasal medium. Joint Meeting of ASCEPT and the British Pharmacological Society, Melbourne, Australia, 26 - 28 April, 2000. Melbourne, Vic.: Blackwell Scientific Publications.
Ross, F. B., Cabot, P. J., Robertson, A. D. and Smith, M. T. (1999). Antinociceptive potencies and motor effects of the calcium channel blockers, AM336 and ziconotide, following intrathecal administration to FCA-treated rats. 9th World Congress on Pain, Vienna, Austria, 22 - 27 August, 1999. Seattle, USA: IASP Press.
Smith, M. T. and South, S. M. (1999). Effect of testosterone on the antinociceptive effects of iv and icv morphine in adult female Sprague-Dawley rats. 33rd Annual Scientific Meeting of ASCEPT, Darling Harbour, Sydney, 4 - 8 December, 1999. Melbourne, Vic: ASCEPT.
Wright, A.W. and Smith, M. T. (1999). Hydromorphone-3-glucuronide (H3G) is a more potent neuro-excitant than morphine-3-glucuronide (M3G) in the rat. 9th World Congress on Pain, Vienna, Austria, 22 - 27 August, 1999. Seattle, USA: IASP Press.
Incomplete antinociceptive cross-tolerance between oxycodone and morphine in the rat
Nielsen, C., Ross, F. B. and Smith, M. T. (1999). Incomplete antinociceptive cross-tolerance between oxycodone and morphine in the rat. 9th World Congress on Pain, Vienna, Austria, 22 - 27 August, 1999. Seattle, USA: IASP Press.
Cabot, P. J., Ross, F. B., Robertson, A. D. and Smith, M. T. (1999). Inhibition of K+-evoked substance P release from slices of rat spinal cord by the novel calcium channel blockers, AM336 and AM543, relative to ziconotide. 9th World Congress on Pain, Vienna, Austria, 22 - 27 August, 1999. Seatle, USA: IASP Press.
Nissen, L. M., Smith, M. T., Tett, S. E., Williams, B. and Cramond, T. R. (1999). Opioid analgesic prescribing and use - An audit of analgesic prescribing by general practitioners and the Multidisciplinary Pain Centre at Royal Brisbane Hospital. Annual Scientific Meeting of the Australian Pain Society, Freemantle, W.A., 21-25 April 1999. Perth, Western Australia: Australian Pain Society.
Nissen, L. M., Smith, M. T., Tett, S. E., Williams, B. and Cramond, T. R. (1999). Opioid analgesic prescribing and use: An audit of analgesic prescribing by general practitioners and the Multidisciplinary Pain Centre at Royal Brisbane Hospital. Society of Hospital Pharmacists of Australia 24th Federal Conference, Perth, W.A., 25 - 28 November, 1999. Melbourne, Australia: Society of Hospital Pharmacists of Australia.
Nissen, L. M., Smith, M. T., Tett, S. E., Williams, B. and Cramond, T. R. (1999). Opioid analgesic prescribing and use: an audit of analgesic prescribing by general practitioners and the multidisciplinary Pain Centre at Royal Brisbane Hospital. Rationale, Resistance and Research. Royal Brisbane Hospital Health Care Symposium, Royal Brisbane Hospital, Brisbane, 21 - 27 October, 1999. Brisbane, Australia: Royal Brisbane Hospital Res. Foundation.
Systematic investigation of sex differences in the antinociceptive effects of morphine in the rat
South, S. M. and Smith, M. T. (1999). Systematic investigation of sex differences in the antinociceptive effects of morphine in the rat. 9th World Congress on Pain, Vienna, Austria, 22 - 27 August, 1999. Seattle, USA: IASP Press.
Smith, M. T. and Hemstapat, K. (1999). Tissue temperature as a function of heat exposure time using the tail flick latency test for both the dorsal and ventral surfaces of the rat tail. 9th World Congress on Pain, Vienna, Austria, 22 - 27 August, 1999. Seattle, USA: IASP Press.
Nonconventional Opioid Receptors in Human and Rat Lung
Cabot, PJ, Smith, MT, Cramond, TR and Dodd, PR (1992). Nonconventional Opioid Receptors in Human and Rat Lung. PHILADELPHIA: LIPPINCOTT-RAVEN PUBL.
CHENG, SCW, MURPHY, TL, SMITH, MT, COOKSLEY, WGE, HALLIDAY, JW and POWELL, LW (1988). SERIAL CAFFEINE AND ANTIPYRINE CLEARANCES IN THE ASSESSMENT OF DISEASE PROGRESSION WITH PARTICULAR REFERENCE TO LIVER-TRANSPLANTATION. PHILADELPHIA: W B SAUNDERS CO.
CHENG, SCW, MURPHY, TL, SMITH, MT, HALLIDAY, JW and POWELL, LW (1988). DOSE-DEPENDENT PHARMACOKINETICS OF CAFFEINE - RELEVANCE TO THE QUANTITATIVE ASSESSMENT OF LIVER-FUNCTION. BALGOWLAH: ADIS PRESS AUSTRALASIA P/L.
PROPRANOLOL IN PREGNANCY, A 3 YEAR PROSPECTIVE-STUDY
LIVINGSTONE, , SMITH, MT, CRASWELL, PW, BEVAN, EB and EADIE, MJ (1982). PROPRANOLOL IN PREGNANCY, A 3 YEAR PROSPECTIVE-STUDY. NEW YORK: MARCEL DEKKER INC.
Pain-relieving compositions and uses therefore
Smith, M. T. (2008). Pain-relieving compositions and uses therefore. PCT/AU2008/000003: WO/2008/080194.
Method of treatment or prophylaxis
Smith, Maree and Wyse, Bruce (2007). Method of treatment or prophylaxis. WO/2006/066361.
Smith, Maree and Williams, Craig (2006). Methods of treating pain. PCT/AU2005/001976.
Method of treatment or prophylaxis
Smith, Maree Therese and Wyse, Bruce Douglas (2006). Method of treatment or prophylaxis. 2004907332.
Compositions comprising nitric oxide donors and opioid analgesics
Smith, M. T., Brown, L. C., Harvey, M. and Williams, C. M. (2003). Compositions comprising nitric oxide donors and opioid analgesics. PCT/AU03/00335.
Methods of treatment and/or prophylaxis
Smith, M. T. and Brown, L. (2003). Methods of treatment and/or prophylaxis. PCT/AU03/00336.
Pharmacokinetics of some highly metabolised substances
Smith, Maree T. (1983). Pharmacokinetics of some highly metabolised substances. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/597609b
(2023–2028) Therapeutic Innovation Australia Limited
(2023–2026) National Multiple Sclerosis Society-US
(2022–2026) NHMRC Synergy Grants
(2022–2024) University of Sydney
(2022–2024) NHMRC Development Grant
(2022–2023) Argenica Therapeutics Limited
(2022–2023) Multiple Sclerosis Research Australia - Targeted Grant - Neurodegeneration
Neuroprotective role of novel acid-sensing ion channel inhibitor in Multiple sclerosis (MS) disease
(2020–2022) Multiple Sclerosis Research Australia
Development of a first-in-class neuroprotective drug for protecting the brain after stroke
(2019–2021) NHMRC Development Grant
(2019) UQ Major Equipment and Infrastructure
(2019) UQ Major Equipment and Infrastructure
(2018–2020) NHMRC Development Grant
High-throughput ion channel pharmacology
(2018) UQ Major Equipment and Infrastructure
(2017–2018) Prince Charles Hospital Foundation
Novel prolonged-release polymeric microparticles for relief of intractable cancer-related pain
(2016–2019) NHMRC Project Grant
Novel Pain therapeutics discovery: Probing molecular mechanisms
(2016) NHMRC Equipment Grant
ACRF Facility for Molecular Imaging Agents in Cancer (AFMIAC)
(2015–2022) Australian Cancer Research Foundation
(2015–2016) UniQuest Pty Ltd
Novel analgesics for improved relief of cancer induced bone pain
(2015) UQ Collaboration and Industry Engagement Fund - Seed Research Grant
(2014–2023) Therapeutic Innovation Australia Limited
Developing subtype-selective blockers of acid-sensing ion channels for treating peripheral pain
(2014–2017) NHMRC Project Grant
(2014–2015) UniQuest Pty Ltd
Efficacy Profiling Innovation in Novel Pain Therapeutics Discovery
(2013–2018) ARC Linkage Projects
Investigations into the pain relief properties of Komipharm's test compound
(2013–2016) UniQuest Pty Ltd
Oral EMA401 mode of action study in a rat model of post-herpetic neralgia (PHN)
(2013–2015) Spinifex Pharmaceuticals Pty Ltd
Novel analgesics for improved treatment of chronic cancer pain
(2013–2014) Queensland Emory Development Alliance
High throughput electrophysiology platform
(2013) UQ Major Equipment and Infrastructure
Translating health discoveries into products
(2011–2015) Queensland Government Smart Futures Co-Investment Fund
Therapeutic Innovation Australia - Queensland node (Source of funds: EIF)
(2011–2014) Therapeutic Innovation Australia Limited
(2010–2013) ARC Linkage Projects
Novel polymeric microparticles for slow-release intrathecal delivery of analgesics
(2010–2013) ARC Linkage Projects
(2010–2012) UQ Collaboration and Industry Engagement Fund
(2010) UQ Major Equipment and Infrastructure
High content imaging analysis for bioactive and novel therapeutic target evaluation
(2010) UQ Major Equipment and Infrastructure
Alzheimer's disease: Novel MRI Biomarkers for Clinical Diagnosis and Translational Studies
(2009–2013) Queensland Government Smart State National and International Research Alliances Program
(2009–2010) Alchemia Pty Ltd
(2009) UQ Faculty Co-Funding
(2008) Gallipoli Research Foundation
Novel therapeutic for treating painful diabetic neuropathy
(2008) Diabetes Australia Research Trust
(2006–2009) ARC Linkage Projects
(2006–2007) Gallipoli Research Foundation
Advanced Cell Labelling and Imaging Facility
(2006) ARC Linkage Infrastructure, Equipment and Facilities
NHMRC_Equipment Grant = DSI Telemetry System
(2005) NHMRC Equipment Grant
NHMRC_Equipment Grant_HLTH_Pharmacy
(2004–2005) NHMRC Equipment Grant
The analgesic evaluation of novel natural products from the Australian plant Barringtonia acutangula
(2004–2005) Griffith University
(2004) University of Queensland Research Development Grants Scheme
(2003) University of Queensland Research Development Grants Scheme
(2003) NHMRC Equipment Grant
Pharmacological investigation of the toxicological effects of high doses of systemic morphine
(2002–2003) Queensland Cancer Fund
Lipid and liposaccharide based drug delivery systems
(2001–2004) Wellcome Trust
Prevention of chronic complications in the STZ-diabetic rat
(2001–2002) Mayne Bequest Fund
(2001) Brain Research Fund
(2001) Cancer Bequest Fund
Efficacy of oxycodone for relief of neuropathic pain
(2000) Pharmaceutical Society of Australia
Efficacy of oxycodone relative to morphine for the relief of neuropathic pain in rats
(2000) Brain Research Fund
A novel liposaccharide based system for drug/peptide delivery
(1999–2002) Wellcome Trust
(1999) Ramaciotti Foundation
M3G: Further Studies of its CNS Pharmacology
(1998–2000) NHMRC Project Grant
(1998–1999) Queensland Cancer Fund
Evaluating morphine for intra-articular analgesia in dogs using forceplate platform technology.
(1996) John & Mary Kibble Trust
Functional characterisation of opioid binding sites in rat airways
(1996) ARC Australian Research Council (Small grants)
(1995–1997) Queensland Cancer Fund
Sustained release of novel injectable analgesic agents - a pharmacological evaluation in rats
(1995) ARC Australian Research Council (Small grants)
Discovery and Pharmacological Evaluation of Novel Analgesics for the Relief of Ross River Virus Induced Chronic Pain
Doctor Philosophy — Principal Advisor
Other advisors:
Novel long-acting and orally delivered conotoxin-based peptides with both analgesic efficacy and disease modifying potential
Doctor Philosophy — Principal Advisor
Other advisors:
Discovery and development of an Antibiotic Modulator to Break Antibiotic Resistance in a Mouse Infection Model
Doctor Philosophy — Principal Advisor
Other advisors:
Understanding the role acid-sensing ion channels in disease progression and pain associated with neuroinflammatory conditions.
Doctor Philosophy — Associate Advisor
Other advisors:
A novel treatment for chronic pain
Doctor Philosophy — Associate Advisor
Other advisors:
Novel prolonged-release polymeric particles for relief of intractable neuropathic pain
(2020) Doctor Philosophy — Principal Advisor
Other advisors:
Analgesic efficacy of novel opioid compounds relative to adverse effects in rats
(2019) Doctor Philosophy — Principal Advisor
Other advisors:
Chronic low back pain: pathobiological investigations towards improved treatments
(2019) Doctor Philosophy — Principal Advisor
Other advisors:
Insight into the Pathobiology of Breast Cancer Induced Bone Pain in a Rat Model
(2019) Doctor Philosophy — Principal Advisor
Other advisors:
Cancer Chemotherapy Induced Peripheral Neuropathy (CIPN): Preclinical Studies
(2015) Doctor Philosophy — Principal Advisor
Other advisors:
Cellular and molecular insights into multiple sclerosis-induced neuropathic pain
(2015) Doctor Philosophy — Principal Advisor
Other advisors:
(2014) Doctor Philosophy — Principal Advisor
PATHOPHYSIOLOGICAL MECHANISMS CONTRIBUTING TO PROSTATE CANCER-INDUCED BONE PAIN
(2013) Doctor Philosophy — Principal Advisor
Systematic evaluation of in vitro and in vivo opioid profiling
(2013) Doctor Philosophy — Principal Advisor
(2011) Doctor Philosophy — Principal Advisor
Painful diabetic neuropathy: preclinical studies to improve therapeutic insight
(2009) Doctor Philosophy — Principal Advisor
Other advisors:
Preclinical Studies in Painful Diabetic Neuropathy
(2008) Doctor Philosophy — Principal Advisor
Other advisors:
PHARMACOKINETIC-PHARMACODYNAMIC MODELLING OF ANTI-ALLODYNIC EFFECTS OF GABAPENTIN AND OXYCODONE IN A RODENT MODEL OF PERSISTENT NERUOPATHIC PAIN
(2005) Master Philosophy — Principal Advisor
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
(2003) Doctor Philosophy — Principal Advisor
Other advisors:
Studies investigating (i) The development of antinociceptive tolerance to oxycodone and cross-tolerance with morphine in rats (ii) Elucidation of opioid receptors mediating oxycodone's antinociception using radioligand binding and (iii)antiallodynia of oxycodone and morphine in a rat model of neuropathic pain
(2003) Doctor Philosophy — Principal Advisor
Analgesic Drug Discovery
(2023) Doctor Philosophy — Associate Advisor
Other advisors:
(2019) Doctor Philosophy — Associate Advisor
Other advisors:
Bioanalytical method development and validation to investigate cytochrome P450 mediated drug metabolism in patients receiving extracorporeal life support.
(2019) Doctor Philosophy — Associate Advisor
Other advisors:
Establishment, optimization and characterization of a rat model of breast cancer induced bone pain
(2018) Doctor Philosophy — Associate Advisor
Other advisors:
(2015) Doctor Philosophy — Associate Advisor
Other advisors:
Skin sensitisation prediction using in vitro screening methods
(2015) Doctor Philosophy — Associate Advisor
(2012) Doctor Philosophy — Associate Advisor
Other advisors:
Assessment of Fucoidin efficacy in A-peptide induced Alzheimer¿s disease rodent model
(2009) Doctor Philosophy — Associate Advisor
Other advisors:
(2008) Doctor Philosophy — Associate Advisor
Other advisors:
QUALITY USE OF MEDICINES: FROM DUE TO RURAL COMMUNITY PHARMACY PRACTICE
(2002) Doctor Philosophy — Associate Advisor
Other advisors:
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
Pathobiology of Neuropathic (nerve damage) Pain
Novel neuropathic pain therapeutics discovery
Painful Diabetic Neuropathy: Towards Improved Drug Treatments