The University of Queensland

Pain pharmacology and the pharmacological management of pain

Smith, Maree T. and Muralidharan, Arjun (2014). Pain pharmacology and the pharmacological management of pain. Pain: a textbook for health professionals. (pp. 159-180) edited by Hubert van Griensven, Jenny Strong and Anita M. Unruh. London, United Kingdom: Elsevier.

Antidepressant analgesics

Watson, C. Peter N., Gilron, Ian, Pollock, Bruce G., Lipman, Arthur G. and Smith, Maree T. (2013). Antidepressant analgesics. Wall and Melzack's textbook of pain. (pp. 465-496) edited by Stephen B. McMahon, Martin Koltzenberg, Irene Tracey and Dennis C. Turk. Philadelphia, United States: Elsevier Saunders.

Pharmacogenetics of pain

Smith, Maree T. and Muralidharan, Arjun (2013). Pharmacogenetics of pain. eLS: Citable Reviews in the Life Sciences. (pp. 1-12) Chichester, U.K.: John Wiley & Sons. doi: 10.1002/047001590X

Opioid analgesics

Smith, Maree T. and Goh, Wei H. (2011). Opioid analgesics. Pain management: Current issues and opinions. (pp. 287-306) edited by Gabor B. Racz and Carl E. Noe. Rijeka, Croatia: Intech Open Access.

Pain pharmacology and analgesia

Smith, Maree T. and South, Samantha M. (2008). Pain pharmacology and analgesia. Encyclopedia of Life Support Systems. (pp. 1-80) edited by H. Majewski. Oxford, U.K.: EOLSS Publishers.

Neurobiology of Pain: Identification of novel targets for new pain management medications

Smith, M. T. (2003). Neurobiology of Pain: Identification of novel targets for new pain management medications. Molecular Pathomechanisms and New Trends in Drug Research. (pp. 302-318) edited by G. Keri and I. Toth. London & New York: Taylor & Francis.

Clinical pharmacology and adverse effects

Mather, L. E. and Smith, M. T. (1999). Clinical pharmacology and adverse effects. Opioids in pain control: Basic and clinical aspects. (pp. 188-211) edited by Christoph Stein. New Jersey, USA: Cambridge University Press.

Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain

Kong, Dehui, Saqer, Alaa A., Carpinelli de Jesus, Matheus, Khan, Nemat, Jones, Alun, Blanchfield, Joanne T., Smith, Maree T. and Williams, Craig M. (2022). Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain. Bioorganic & Medicinal Chemistry, 69 116889, 116889. doi: 10.1016/j.bmc.2022.116889

Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy

Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy. Advanced Therapeutics 2200109, 2200109. doi: 10.1002/adtp.202200109

Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial

Smith, Maree T. (2022). Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial. Pain, Publish Ahead of Print. doi: 10.1097/j.pain.0000000000002675

Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat

Han, Felicity Y., Brockman, David A., Nicholson, Janet R., Corradini, Laura and Smith, Maree Therese (2022). Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat. Behavioural Pharmacology, 33 (1), 23-31. doi: 10.1097/fbp.0000000000000663

Journey to the market: The evolution of biodegradable drug delivery systems

Zhu, Minze, Whittaker, Andrew K., Han, Felicity Y. and Smith, Maree T. (2022). Journey to the market: The evolution of biodegradable drug delivery systems. Applied Sciences, 12 (2) 935. doi: 10.3390/app12020935

Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources

Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2022). Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources. Journal of Medicinal Chemistry, 65 (3) acs.jmedchem.0c01915, 1612-1661. doi: 10.1021/acs.jmedchem.0c01915

Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice

Xu, Weizhi, Maqbool, Faheem, Kumar, Vinod, Falconer, James R., Cui, Cedric S., Woodruff, Trent M., Borges, Karin, Whittaker, Andrew K., Smith, Maree T. and Han, Felicity Y. (2021). Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice. Drug Delivery and Translational Research, 12 (10), 2518-2526. doi: 10.1007/s13346-021-01093-3

Pharmacological characterization of the chronic phase of the monoiodoacetate‐induced rat model of osteoarthritis pain in the knee joint

Han, Felicity Y., Brockman, David A., Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2021). Pharmacological characterization of the chronic phase of the monoiodoacetate‐induced rat model of osteoarthritis pain in the knee joint. Clinical and Experimental Pharmacology and Physiology, 48 (11) 1440-1681.13551, 1515-1522. doi: 10.1111/1440-1681.13551

Editorial: verification of animal pain models by reverse translation

Caudle, Robert M., Smith, Maree Therese and Romero-Sandoval, E. Alfonso (2021). Editorial: verification of animal pain models by reverse translation. Frontiers in Pharmacology, 12 778880, 778880. doi: 10.3389/fphar.2021.778880

Optimisation of a microfluidic method for the delivery of a small peptide

Han, Felicity Y., Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria, Jiang, Xingyu, Woodruff, Trent M., Whittaker, Andrew K. and Smith, Maree T. (2021). Optimisation of a microfluidic method for the delivery of a small peptide. Pharmaceutics, 13 (9) 1505, 1505. doi: 10.3390/pharmaceutics13091505

Assessment of the anti-allodynic and anti-hyperalgesic efficacy of a glycine transporter 2 inhibitor relative to pregabalin, duloxetine and indomethacin in a rat model of cisplatin-induced peripheral neuropathy

Kuo, Andy, Corradini, Laura, Nicholson, Janet R. and Smith, Maree T. (2021). Assessment of the anti-allodynic and anti-hyperalgesic efficacy of a glycine transporter 2 inhibitor relative to pregabalin, duloxetine and indomethacin in a rat model of cisplatin-induced peripheral neuropathy. Biomolecules, 11 (7) 940, 1-17. doi: 10.3390/biom11070940

Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO2 process

Xu, Weizhi, Zhao, Zonglan, Falconer, James, Whittaker, Andrew K., Popat, Amirali, Smith, Maree T., Kumeria, Tushar and Han, Felicity Y. (2021). Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO2 process. Drug Delivery and Translational Research, 12 (3), 676-694. doi: 10.1007/s13346-021-00991-w

Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods

Park, Thomas S.W., Khan, Nemat, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2021). Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods. Clinical and Experimental Pharmacology and Physiology, 48 (1) 1440-1681.13402, 96-106. doi: 10.1111/1440-1681.13402

Use of microfluidics to fabricate bioerodable lipid hybrid nanoparticles containing hydromorphone or ketamine for the relief of intractable pain

Zhu, Minze, Whittaker, Andrew K., Jiang, Xingyu, Tang, Rupei, Li, Xuanyu, Xu, Weizhi, Fu, Changkui, Smith, Maree T. and Han, Felicity Y. (2020). Use of microfluidics to fabricate bioerodable lipid hybrid nanoparticles containing hydromorphone or ketamine for the relief of intractable pain. Pharmaceutical Research, 37 (10) 211, 1-12. doi: 10.1007/s11095-020-02939-0

Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris

Agnew-Francis, Kylie A., Tang, Yu Cheng, Lin, Xin, Low, Yu Shang, Wun, Shun Jie, Kuo, Andy, Elias, S. M. A. Sayeed Ibn, Lonhienne, Thierry G., Condon, Nicholas, Pimentel, Bruna Natalia Alves da Silva, Vergani, Carlos, Smith, Maree T., Fraser, James A., Williams, Craig M. and Guddat, Luke W (2020). Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris. ACS infectious diseases, 6 (11) acsinfecdis.0c00229, 2901-2912. doi: 10.1021/acsinfecdis.0c00229

Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain

Imam, Mohammad Zafar, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2020). Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain. Pharmacological Reports, 72 (5), 1418-1425. doi: 10.1007/s43440-020-00145-8

Assessment of the anti‐hyperalgesic efficacy of J‐2156, relative to clinically available analgesic/adjuvant agents in a rat model of mild to moderate chronic mechanical low back pain (LBP)

Kuo, Andy, Lourdesamy, Jacintha, Nicholson, Janet R., Corradini, Laura and Maree, Smith T. (2020). Assessment of the anti‐hyperalgesic efficacy of J‐2156, relative to clinically available analgesic/adjuvant agents in a rat model of mild to moderate chronic mechanical low back pain (LBP). Clinical and Experimental Pharmacology and Physiology, 47 (12) 1440-1681.13383, 1912-1922. doi: 10.1111/1440-1681.13383

Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease

Edwards, Stephen R., Khan, Nemat, Coulson, Elizabeth J. and Smith, Maree T. (2020). Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease. Clinical and Experimental Pharmacology and Physiology, 47 (10) 1440-1681.13363, 1740-1750. doi: 10.1111/1440-1681.13363

Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation

Han, Felicity Y., Liu, Yun, Kumar, Vinod, Xu, Weizhi, Yang, Guangze, Zhao, Chun-Xia, Woodruff, Trent M., Whittaker, Andrew K. and Smith, Maree T. (2020). Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation. International Journal of Pharmaceutics, 581 119291, 119291. doi: 10.1016/j.ijpharm.2020.119291

In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile

Kuo, Andy, Magiera, Julia, Rethwan, Nursyazwani, Andersson, Åsa, Leen Lam, Ai, Wyse, Bruce, Meutermans, Wim, Lewis, Richard and Smith, Maree (2020). In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile. European Journal of Pharmacology, 872 172947, 172947. doi: 10.1016/j.ejphar.2020.172947

Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine

Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2020). Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine. European Journal of Pharmacology, 871 172918, 172918. doi: 10.1016/j.ejphar.2020.172918

Countering opioid-induced respiratory depression by non-opioids that are respiratory stimulants

Imam, Mohammad Zafar, Kuo, Andy and Smith, Maree T. (2020). Countering opioid-induced respiratory depression by non-opioids that are respiratory stimulants. F1000Research, 9 91, 91. doi: 10.12688/f1000research.21738.1

Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell-induced bone pain

Shenoy, Priyank A., Kuo, Andy, Leparc, German, Hildebrandt, Tobias, Rust, Werner, Nicholson, Janet R., Corradini, Laura, Vetter, Irina and Smith, Maree T. (2019). Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell-induced bone pain. Clinical and Experimental Pharmacology and Physiology, 46 (12) 1440-1681.13165, 1201-1215. doi: 10.1111/1440-1681.13165

J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain

Park, Thomas S.W., Khan, Nemat, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2019). J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain. Biomedicine and Pharmacotherapy, 117 109056, 109056. doi: 10.1016/j.biopha.2019.109056

The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement

Houston, Sevan D., Fahrenhorst-Jones, Tyler, Xing, Hui, Chalmers, Benjamin A., Sykes, Melissa L., Stok, Jeanette E., Farfan Soto, Clementina, Burns, Jed M., Bernhardt, Paul V., De Voss, James J., Boyle, Glen M., Smith, Maree T., Tsanaktsidis, John, Savage, G. Paul, Avery, Vicky M. and Williams, Craig M. (2019). The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement. Organic and Biomolecular Chemistry, 17 (28), 6790-6798. doi: 10.1039/c9ob01238a

Study Protocol for a Pilot, Open-Label, Prospective, and Observational Study to Evaluate the Pharmacokinetics of Drugs Administered to Patients during Extracorporeal Circulation; Potential of In Vivo Cytochrome P450 Phenotyping to Optimise Pharmacotherapy

Adiraju, Santosh Kumar Sreevatsav, Shekar, Kiran, Tesar, Peter, Naidoo, Rishendran, Rapchuk, Ivan, Belz, Stephen, Fraser, John F., Smith, Maree T. and Ghassabian, Sussan (2019). Study Protocol for a Pilot, Open-Label, Prospective, and Observational Study to Evaluate the Pharmacokinetics of Drugs Administered to Patients during Extracorporeal Circulation; Potential of In Vivo Cytochrome P450 Phenotyping to Optimise Pharmacotherapy. Methods and Protocols, 2 (2) 38, 38-12. doi: 10.3390/mps2020038

Nitric oxide modulates μ‐opioid receptor function in vitro

Huang, Lillian, Wyse, Bruce D., Williams, Craig M. and Smith, Maree T. (2019). Nitric oxide modulates μ‐opioid receptor function in vitro. Clinical and Experimental Pharmacology and Physiology, 46 (7) 1440-1681.13091, 676-685. doi: 10.1111/1440-1681.13091

Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods

Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2019). Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods. Inflammopharmacology, 27 (2), 387-396. doi: 10.1007/s10787-018-00551-8

Bioerodable ketamine-loaded microparticles fabricated using dissolvable hydrogel template technology

Zhu, Minze, Whittaker, Andrew K., Smith, Maree T. and Han, Felicity Y. (2019). Bioerodable ketamine-loaded microparticles fabricated using dissolvable hydrogel template technology. Journal of Pharmaceutical Sciences, 108 (3), 1220-1226. doi: 10.1016/j.xphs.2018.10.029

Cyclooctatetraene: a bioactive cubane paradigm complement

Xing, Hui, Houston, Sevan D., Chen, Xuejie, Ghassabian, Sussan, Fahrenhorst-Jones, Tyler, Kuo, Andy, Murray, Cody-Ellen P., Conn, Kyna-Anne, Jaeschke, Kara N., Jin, Da-Yun, Pasay, Cielo, Bernhardt, Paul V., Burns, Jed M., Tsanaktsidis, John, Savage, G. Paul, Boyle, Glen M., De Voss, James J., McCarthy, James, Walter, Gimme H., Burne, Thomas H. J., Smith, Maree T., Tie, Jian-Ke and Williams, Craig M. (2019). Cyclooctatetraene: a bioactive cubane paradigm complement. Chemistry: A European Journal, 25 (11), 2729-2734. doi: 10.1002/chem.201806277

Sustained-release hydromorphone microparticles produced by supercritical fluid polymer encapsulation

Han, Felicity Y., Whittaker, Andrew, Howdle, Steven M., Naylor, Andrew, Shabir-Ahmed, Anjumn and Smith, Maree T. (2019). Sustained-release hydromorphone microparticles produced by supercritical fluid polymer encapsulation. Journal of Pharmaceutical Sciences, 108 (2), 811-814. doi: 10.1016/j.xphs.2018.09.021

Formulation of bioerodible ketamine microparticles as an analgesic adjuvant treatment produced by supercritical fluid polymer encapsulation

Han, Felicity, Whittaker, Andrew, Howdle, Steven, Naylor, Andrew, Shabir-Ahmed, Anjumn, Zhang, Cheng and Smith, Maree (2018). Formulation of bioerodible ketamine microparticles as an analgesic adjuvant treatment produced by supercritical fluid polymer encapsulation. Pharmaceutics, 10 (4) 264, 264. doi: 10.3390/pharmaceutics10040264

An improved LC-MS/MS method for simultaneous evaluation of CYP2C9, CYP2C19, CYP2D6 and CYP3A4 activity

Sreevatsav Adiraju, Santosh Kumar, Shekar, Kiran, Fraser, John F., Smith, Maree T. and Ghassabian, Sussan (2018). An improved LC-MS/MS method for simultaneous evaluation of CYP2C9, CYP2C19, CYP2D6 and CYP3A4 activity. Bioanalysis, 10 (19), 1577-1590. doi: 10.4155/bio-2018-0102

Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675)

Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2018). Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675). Angewandte Chemie - International Edition, 57 (28), 8359-8359. doi: 10.1002/anie.201711161

Effects of long-term opioid analgesics on cognitive performance and plasma cytokine concentrations in patients with chronic low back pain : a cross-sectional pilot study

Richards, Georgia C., Lluka, Lesley J., Smith, Maree T., Haslam, Catherine, Moore, Brendan, OʼCallaghan, James and Strong, Jenny (2018). Effects of long-term opioid analgesics on cognitive performance and plasma cytokine concentrations in patients with chronic low back pain : a cross-sectional pilot study. PAIN Reports, 3 (4) e669, e669. doi: 10.1097/pr9.0000000000000669

In vivo profiling of four centrally administered opioids for antinociception, constipation and respiratory depression: between colony differences in Sprague Dawley rats

Kuo, Andy and Smith, Maree T. (2018). In vivo profiling of four centrally administered opioids for antinociception, constipation and respiratory depression: between colony differences in Sprague Dawley rats. Clinical and Experimental Pharmacology & Physiology, 45 (10), 1056-1066. doi: 10.1111/1440-1681.12972

Comparative analgesic efficacy of pregabalin administered according to either a prevention protocol or an intervention protocol in rats with cisplatin-induced peripheral neuropathy

Han, Felicity Y., Kuo, Andy, Nicholson, Janet R., Corradinni, Laura and Smith, Maree T. (2018). Comparative analgesic efficacy of pregabalin administered according to either a prevention protocol or an intervention protocol in rats with cisplatin-induced peripheral neuropathy. Clinical and Experimental Pharmacology and Physiology, 45 (10), 1067-1075. doi: 10.1111/1440-1681.12971

Chronic low back pain: a mini-review on pharmacological management and pathophysiological insights from clinical and pre-clinical data

Park, Thomas S. W., Kuo, Andy and Smith, Maree T. (2018). Chronic low back pain: a mini-review on pharmacological management and pathophysiological insights from clinical and pre-clinical data. Inflammopharmacology, 26 (4), 1-18. doi: 10.1007/s10787-018-0493-x

The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain

Shenoy, Priyank A., Kuo, Andy, Khan, Nemat, Gorham, Louise, Nicholson, Janet, Corradini, Laura, Vetter, Irina and Smith, Maree T. (2018). The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain. Frontiers in Pharmacology, 9 (MAY) 495, 495. doi: 10.3389/fphar.2018.00495

An improved liquid chromatography tandem mass spectrometry (LC-MS/MS) method for quantification of dexmedetomidine concentrations in samples of human plasma

Moosavi, Seyed Mojtaba, Shekar, Kiran, Fraser, John F., Smith, Maree T. and Ghassabian, Sussan (2018). An improved liquid chromatography tandem mass spectrometry (LC-MS/MS) method for quantification of dexmedetomidine concentrations in samples of human plasma. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1073, 118-122. doi: 10.1016/j.jchromb.2017.12.006

Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain

Lee, Jia Yu Peppermint, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, King, Glenn F., Smith, Maree T. and Rash, Lachlan D. (2018). Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. British Journal of Pharmacology, 175 (12), 2204-2218. doi: 10.1111/bph.14089

Synthesis and Biological Evaluation of Fentanyl Analogues Modified at Phenyl Groups with Alkyls

Qin, Yajuan, Ni, Luofan, Shi, Jiawei, Zhu, Zhiying, Shi, Saijian, Lam, Ai-Leen, Magiera, Julia, Sekar, Sunderajhan, Kuo, Andy, Smith, Maree T. and Li, Tingyou (2018). Synthesis and Biological Evaluation of Fentanyl Analogues Modified at Phenyl Groups with Alkyls. ACS Chemical Neuroscience, 10 (1) acschemneuro.8b00363, 201-208. doi: 10.1021/acschemneuro.8b00363

Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression

Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan and Smith, Maree T. (2017). Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression. Neuropharmacology, 131, 238-255. doi: 10.1016/j.neuropharm.2017.12.032

Effect of cardiopulmonary bypass on cytochrome P450 enzyme activity: implications for pharmacotherapy

Adiraju, Santosh Kumar Sreevatsav, Shekar, Kiran, Fraser, John F, Smith, Maree T and Ghassabian, Sussan (2017). Effect of cardiopulmonary bypass on cytochrome P450 enzyme activity: implications for pharmacotherapy. Drug metabolism reviews, 50 (2), 1-16. doi: 10.1080/03602532.2017.1417423

Morphine hyposensitivity in STZ-diabetic rats: reversal by dietary L-arginine treatment

Lotfipour, Shahrdad and Smith, Maree T. (2017). Morphine hyposensitivity in STZ-diabetic rats: reversal by dietary L-arginine treatment. Clinical and Experimental Pharmacology & Physiology, 45 (1), 42-49. doi: 10.1111/1440-1681.12855

Attenuation of the Infiltration of Angiotensin II Expressing CD3(+) T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia - A Possible Mechanism Underpinning Analgesia Produced by EMA300, An Angiotensin II Type 2 (AT(2)) Receptor Antagonist

Khan, Nemat, Muralidharan, Arjun and Smith, Maree T. (2017). Attenuation of the Infiltration of Angiotensin II Expressing CD3(+) T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia - A Possible Mechanism Underpinning Analgesia Produced by EMA300, An Angiotensin II Type 2 (AT(2)) Receptor Antagonist. Frontiers in Molecular Neuroscience, 10 389, 389. doi: 10.3389/fnmol.2017.00389

Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain

Khan, Nemat, Kuo, Andy, Brockman, David A, Cooper, Matthew A and Smith, Maree T (2017). Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain. Inflammopharmacology, 26 (1), 77-86. doi: 10.1007/s10787-017-0401-9

Establishment and characterization of a novel rat model of mechanical low back pain using behavioral, pharmacologic and histologic methods

Muralidharan, Arjun, Park, Thomas S. W., Mackie, John T., Gimenez, Luiz G. S., Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2017). Establishment and characterization of a novel rat model of mechanical low back pain using behavioral, pharmacologic and histologic methods. Frontiers in Pharmacology, 8 493, 493.1-493.12. doi: 10.3389/fphar.2017.00493

Optimization and in vivo profiling of a refined rat model of Walker 256 breast cancer cell-induced bone pain using behavioral, radiological, histological, immunohistochemical and pharmacological methods

Shenoy, Priyank, Kuo, Andy, Vetter, Irina and Smith, Maree T. (2017). Optimization and in vivo profiling of a refined rat model of Walker 256 breast cancer cell-induced bone pain using behavioral, radiological, histological, immunohistochemical and pharmacological methods. Frontiers in Pharmacology, 8 (JUL) 442, 442. doi: 10.3389/fphar.2017.00442

High-throughput assay for quantification of the plasma concentrations of thiopental using automated solid phase extraction (SPE) directly coupled to LC–MS/MS instrumentation

Moosavi, Seyed Mojtaba, Shekar, Kiran, Fraser, John, Smith, Maree T. and Ghassabian, Sussan (2016). High-throughput assay for quantification of the plasma concentrations of thiopental using automated solid phase extraction (SPE) directly coupled to LC–MS/MS instrumentation. Journal of Chromatography B, 1038, 80-87. doi: 10.1016/j.jchromb.2016.10.038

The Walker 256 breast cancer cell-induced bone pain model in rats

Shenoy, Priyank A., Kuo, Andy, Vetter, Irina and Smith, Maree T. (2016). The Walker 256 breast cancer cell-induced bone pain model in rats. Frontiers in Pharmacology, 7 (AUG) 286, 286. doi: 10.3389/fphar.2016.00286

Bioerodable PLGA-based microparticles for producing sustained-release drug formulations and strategies for improving drug loading

Han, Felicity Y., Thurecht, Kristofer J., Whittaker, Andrew K. and Smith, Maree T. (2016). Bioerodable PLGA-based microparticles for producing sustained-release drug formulations and strategies for improving drug loading. Frontiers in Pharmacology, 7 (JUN) 185, 1-11. doi: 10.3389/fphar.2016.00185

Comparison of burrowing and stimuli-evoked pain behaviors as end-points in rat models of inflammatory pain and peripheral neuropathic pain

Muralidharan, Arjun, Kuo, Andy, Jacob, Meera, Lourdesamy, Jacintha S., Melo Sores Pinho De Carvalho, Lara, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2016). Comparison of burrowing and stimuli-evoked pain behaviors as end-points in rat models of inflammatory pain and peripheral neuropathic pain. Frontiers in Behavioral Neuroscience, 10 (88) 88, 88. doi: 10.3389/fnbeh.2016.00088

In Vitro Metabolic Stability and in Vivo Biodistribution of 3‑Methyl-4- furoxancarbaldehyde Using PET Imaging in Rats

Pippin, Adam B., Mohd Arshad, Zaira Hidayah, Vol, Ronald J., Nye, Jonathon A., Ghassabian, Sussan, Williams, Craig M., Mancini, Alessandra, Liotta, Dennis C., Smith, Maree T. and Goodman, Mark M. (2016). In Vitro Metabolic Stability and in Vivo Biodistribution of 3‑Methyl-4- furoxancarbaldehyde Using PET Imaging in Rats. ACS Medicinal Chemistry Letters, 7 (6), 563-567. doi: 10.1021/acsmedchemlett.5b00410

Frontispiece: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere

Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2016). Frontispiece: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere. Angewandte Chemie International Edition, 55 (11), 8359-8359. doi: 10.1002/anie.201681161

Evaluation of a high-throughput peptide reactivity format assay for assessment of the skin sensitization potential of chemicals

Wong, Chin Lin, Lam, Ai Leen, Smith, Maree T. and Ghassabian, Sussan (2016). Evaluation of a high-throughput peptide reactivity format assay for assessment of the skin sensitization potential of chemicals. Frontiers in Pharmacology, 7 (MAR) 53, 53. doi: 10.3389/fphar.2016.00053

Validating Eaton's hypothesis: cubane as a benzene bioisostere

Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2016). Validating Eaton's hypothesis: cubane as a benzene bioisostere. Angewandte Chemie (International Edition), 55 (11), 3580-3585. doi: 10.1002/anie.201510675

Selective small molecule angiotensin II type 2 (AT2) receptor antagonists for neuropathic pain: preclinical and clinical studies

Smith, Maree T., Anand, Praveen and Rice, Andrew S. C. (2016). Selective small molecule angiotensin II type 2 (AT2) receptor antagonists for neuropathic pain: preclinical and clinical studies. Pain, 157 (Supplement 1), S33-S41. doi: 10.1097/j.pain.0000000000000369

Why different pain-killers are only effective for certain types of pain

Smith, Maree (2015, 12 14). Why different pain-killers are only effective for certain types of pain

A novel fully validated LC-MS/MS method for quantification of pyridoxal-5'-phosphate concentrations in samples of human whole blood

Ghassabian, Sussan, Griffiths, Lyn and Smith, Maree T (2015). A novel fully validated LC-MS/MS method for quantification of pyridoxal-5'-phosphate concentrations in samples of human whole blood. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1000, 77-83. doi: 10.1016/j.jchromb.2015.07.019

Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain

Han, Felicity Y., Thurecht, Kristofer J., Lam, Ai-Leen, Whittaker, Andrew K. and Smith, Maree T. (2015). Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain. Journal of Pharmaceutical Sciences, 104 (7), 2334-2344. doi: 10.1002/jps.24497

Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture, TPM) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure

Smith, Maree T., Wyse, Bruce D., Edwards, Stephen R., El-Taminy, Mahmoud, Gaetano, Giacinto and Gavin, Paul (2015). Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture, TPM) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure. Journaal of Pharmaceutical Sciences, 104 (7), 2388-2396. doi: 10.1002/jps.24502

The Furoxan Nitric Oxide Donor, PRG150, Evokes Dose-Dependent Analgesia in a Rat Model of Painful Diabetic Neuropathy (PDN)

Huang, Lillian Y., Tsui, Debbie Y., Williams, Craig M., Wyse, Bruce D. and Smith, Maree T. (2015). The Furoxan Nitric Oxide Donor, PRG150, Evokes Dose-Dependent Analgesia in a Rat Model of Painful Diabetic Neuropathy (PDN). Clinical and Experimental Pharmacology and Physiology, 42 (9), 921-929. doi: 10.1111/1440-1681.12442

In vivo High Angular Resolution Diffusion-Weighted Imaging of Mouse Brain at 16.4 Tesla

Alomair, Othman I, Brereton, Ian M, Smith, Maree T, Galloway, Graham J and Kurniawan, Nyoman D (2015). In vivo High Angular Resolution Diffusion-Weighted Imaging of Mouse Brain at 16.4 Tesla. Plos One, 10 (6) e0130133, e0130133. doi: 10.1371/journal.pone.0130133

Neurotrophins and neuropathic pain: role in pathobiology

Khan, Nemat and Smith, Maree T. (2015). Neurotrophins and neuropathic pain: role in pathobiology. Molecules, 20 (6), 10657-10688. doi: 10.3390/molecules200610657

Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cord

Khan, Nemat, Gordon, Richard, Woodruff, Trent M. and Smith, Maree T. (2015). Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cord. Pharmacology Research and Perspectives, 3 (3) e00137, 1-16. doi: 10.1002/prp2.137

In vitro methods for hazard assessment of industrial chemical - opportunities and challenges

Wong, Chin Lin, Ghassabian, Sussan, Smith, Maree T. and Lam, Ai-Leen (2015). In vitro methods for hazard assessment of industrial chemical - opportunities and challenges. Frontiers in Pharmacology, 6 (94) 94, 1-13. doi: 10.3389/fphar.2015.00094

Angiotensin II Type 2-Receptor: New Clinically Validated Target in the Treatment of Neuropathic Pain

Rice, A. S. C. and Smith, M. T. (2015). Angiotensin II Type 2-Receptor: New Clinically Validated Target in the Treatment of Neuropathic Pain. Clinical Pharmacology and Therapeutics, 97 (2), 128-130. doi: 10.1002/cpt.29

Fully validated LC–MS/MS method for quantification of homocysteine concentrations in samples of human serum: a new approach

Ghassabian, Sussan, Rethwan, Nur Syazwani Ahmad, Griffiths, Lyn and Smith, Maree T. (2014). Fully validated LC–MS/MS method for quantification of homocysteine concentrations in samples of human serum: a new approach. Journal of Chromatography B, 972, 14-21. doi: 10.1016/j.jchromb.2014.09.032

Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods

Khan, Nemat, Woodruff, Trent M. and Smith, Maree T. (2014). Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 126, 13-27. doi: 10.1016/j.pbb.2014.09.003

Optimization and pharmacological characterization of a refined cisplatin-induced rat model of peripheral neuropathic pain

Han, Felicity Yaqin, Wyse, Bruce D. and Smith, Maree T. (2014). Optimization and pharmacological characterization of a refined cisplatin-induced rat model of peripheral neuropathic pain. Behavioural Pharmacology, 25 (8), 732-740. doi: 10.1097/FBP.0000000000000090

Targeting angiotensin II type 2 receptor pathways to treat neuropathic pain and inflammatory pain

Smith, Maree T. and Muralidharan, Arjun (2014). Targeting angiotensin II type 2 receptor pathways to treat neuropathic pain and inflammatory pain. Expert Opinion On Therapeutic Targets, 19 (1), 25-35. doi: 10.1517/14728222.2014.957673

Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models Of Alzheimer's disease

Edwards, Stephen R., Hamlin, Adam S., Marks, Nicola, Coulson, Elizabeth J. and Smith, Maree T. (2014). Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models Of Alzheimer's disease. Clinical and Experimental Pharmacology and Physiology, 41 (10), 798-806. doi: 10.1111/1440-1681.12277

Theoretical and practical applications of the intracerebroventricular route for CSF sampling and drug administration in CNS drug discovery research: a mini review

Kuo, Andy and Smith, Maree T. (2014). Theoretical and practical applications of the intracerebroventricular route for CSF sampling and drug administration in CNS drug discovery research: a mini review. Journal of Neuroscience Methods, 233, 166-171. doi: 10.1016/j.jneumeth.2014.06.006

Analgesic efficacy of small-molecule angiotensin II type 2 receptor antagonists in a rat model of antiretroviral toxic polyneuropathy

Smith, Maree T., Lau, Tanya, Wallace, Victoria C. J., Wyse, Bruce D. and Rice, Andrew S. C. (2014). Analgesic efficacy of small-molecule angiotensin II type 2 receptor antagonists in a rat model of antiretroviral toxic polyneuropathy. Behavioural Pharmacology, 25 (2), 137-146. doi: 10.1097/FBP.0000000000000025

Endomorphin analogues with mixed mu-opioid (MOP) receptor agonism/delta-opioid (DOP) receptor antagonism and lacking beta-arrestin2 recruitment activity

Cai, Jun, Song, Bowen, Cai, Yunxin, Ma, Yu, Lam, Ai-leen, Magiera, Julia, Sekar, Sunder, Wyse, Bruce D., Ambo, Akihiro, Sasaki, Yusuke, Lazarus, Lawrence H., Smith, Maree T. and Li, Tingyou (2014). Endomorphin analogues with mixed mu-opioid (MOP) receptor agonism/delta-opioid (DOP) receptor antagonism and lacking beta-arrestin2 recruitment activity. Biorganic and Medicinal Chemistry, 22 (7), 2208-2219. doi: 10.1016/j.bmc.2014.02.015

In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile

Kuo, A., Wyse, B. D., Meutermans, W. and Smith, M. T. (2014). In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile. British Journal of Pharmacology, Accepted Article (2), 1-48. doi: 10.1111/bph.12696

Analgesic efficacy and mode of action of a selective small molecule angiotensin II type 2 receptor antagonist in a rat model of prostate cancer-induced bone pain

Muralidharan, Arjun, Wyse, Bruce D. and Smith, Maree T. (2014). Analgesic efficacy and mode of action of a selective small molecule angiotensin II type 2 receptor antagonist in a rat model of prostate cancer-induced bone pain. Pain Medicine, 15 (1), 93-110. doi: 10.1111/pme.12258

Current developments in MRI for assessing rodent models of multiple sclerosis

Alomair, Othman I., Smith, Maree T., Brereton, Ian M., Galloway, Graham J. and Kurniawan, Nyoman D. (2014). Current developments in MRI for assessing rodent models of multiple sclerosis. Future Neurology, 9 (4), 487-511. doi: 10.2217/FNL.14.33

Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN)

Han, Yaqin and Smith, Maree T. (2013). Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN). Frontiers in Pharmacology, 4 Article 156, 1-16. doi: 10.3389/fphar.2013.00156

Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models

Khan, Nemat and Smith, Maree T. (2013). Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models. Inflammopharmacology, 22 (1), 1-22. doi: 10.1007/s10787-013-0195-3

Comment On "protective Arms of the Renin-Angiotensin System in Neurological Disease"

Smith, Maree T. and Muralidharan, Arjun (2013). Comment On "protective Arms of the Renin-Angiotensin System in Neurological Disease". Clinical and Experimental Pharmacology and Physiology, 40 (11), 838-838. doi: 10.1111/1440-1681.12169

Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments

Muralidharan, Arjun and Smith, Maree T. (2013). Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments. Inflammopharmacology, 21 (5), 339-363. doi: 10.1007/s10787-013-0183-7

A small molecule angiotensin II type 2 receptor (AT2R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia

Smith, Maree T., Woodruff, Trent M., Wyse, Bruce D., Muralidharan, Arjun and Walther, Thomas (2013). A small molecule angiotensin II type 2 receptor (AT2R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 Mitogen-Activated Protein Kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia. Pain Medicine, 14 (10), 1557-1568. doi: 10.1111/pme.12157

Small molecule angiotensin II type 2 receptor (AT2R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats

Smith, Maree T., Wyse, Bruce D. and Edwards, Stephen R. (2013). Small molecule angiotensin II type 2 receptor (AT2R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats. Pain Medicine, 14 (5), 692-705. doi: 10.1111/pme.12063

Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation

Varamini, Pegah, Goh, Wei Huang, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2013). Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation. Bioorganic & Medicinal Chemistry, 21 (7), 1898-1904. doi: 10.1016/j.bmc.2013.01.044

The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation

Shekar, Kiran, Roberts, Jason A., Smith, Maree T., Fung, Yoke L. and Fraser, John F. (2013). The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation. BMC Anesthesiology, 13 (1) 7, 7.1-7.10. doi: 10.1186/1471-2253-13-7

Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioural, pharmacological, radiological, histological and immunohistochemical methods

Muralidharan, Arjun, Wyse, Bruce D. and Smith, Maree T. (2013). Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioural, pharmacological, radiological, histological and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 106, 33-46. doi: 10.1016/j.pbb.2013.02.020

The erythropoietin-derived peptide ARA290 reverses mechanical allodynia in the neuritis model

Pulman, K. G. T., Smith, M., Mengozzi, M., Ghezzi, P. and Dilley, A. (2012). The erythropoietin-derived peptide ARA290 reverses mechanical allodynia in the neuritis model. Neuroscience, 233, 174-183. doi: 10.1016/j.neuroscience.2012.12.022

ASAP ECMO: antibiotic, sedative and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO

Shekar, Kiran, Roberts, Jason A., Welsh, Susan, Buscher, Hergen, Rudham, Sam, Burrows, Fay, Ghassabian, Sussan, Wallis, Steven C., Levkovich, Bianca, Pellegrino, Vin, McGuiness, Shay, Parke, Rachael, Gilder, Eileen, Barnett, Adrian G., Walsham, James, Mullany, Daniel V., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012). ASAP ECMO: antibiotic, sedative and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO. BMC Anesthesiology, 12 (1) 29, 29.1-29.9. doi: 10.1186/1471-2253-12-29

Sedation during extracorporeal membrane oxygenation-why more is less

Shekar, K., Roberts, J. A., Ghassabian, S., Mullany, D. V., Ziegenfuss, M., Smith, M. T., Fung, Y. L. and Fraser, J. F. (2012). Sedation during extracorporeal membrane oxygenation-why more is less. Anaesthesia and Intensive Care, 40 (6), 1067-1069.

Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?

Shekar, Kiran, Roberts, Jason A., Ghassabian, Sussan, Mullany, Daniel V., Wallis, Steven C., Smith, Maree T. and Fraser, John F. (2012). Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?. Journal of Antimicrobial Chemotherapy, 68 (3), 726-727. doi: 10.1093/jac/dks435

Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation

Shekar, Kiran, Roberts, Jason A., McDonald, Charles I., Fisquet, Stephanie, Barnett, Adrian G., Mullany, Daniel V., Ghassabian, Sussan, Wallis, Steven C., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012). Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation. Critical Care, 16 (5) R194, R194.1-R194.7. doi: 10.1186/cc11679

Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation

Varamini, Pegah, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2012). Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation. PLoS One, 7 (8 Article. No.e41909) e41909, e41909. doi: 10.1371/journal.pone.0041909

High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS

Ghassabian, Sussan, Moosavi, Seyed Mojtaba, Valero, Yarmarly Guerra, Shekar, Kiran, Fraser, John F. and Smith, Maree T. (2012). High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS. Journal of Chromatography B, 903, 126-133. doi: 10.1016/j.jchromb.2012.07.005

Pregabalin for the treatment of fibromyalgia

Smith, Maree T. and Moore, Brendan J. (2012). Pregabalin for the treatment of fibromyalgia. Expert Opinion on Pharmacotherapy, 13 (10), 1527-1533. doi: 10.1517/14656566.2012.687373

Synthesis and biological evaluation of an orally active glycosylated endomorphin-1

Varamini, Pegah, Mansfeld, Friederike M., Blanchfield, Joanne T., Wyse, Bruce D., Smith, Maree T. and Toth, Istvan (2012). Synthesis and biological evaluation of an orally active glycosylated endomorphin-1. Journal of Medicinal Chemistry, 55 (12), 5859-5867. doi: 10.1021/jm300418d

Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions

Shekar, Kiran, Fung, Yoke L., Diab, Sara, Mullany, Daniel V., McDonald, Charles I, Dunster, Kimble R., Fisquet, Kimble R, Platts, David G., Stewart, David G, Wallis, Steven C., Smith, Maree T., Roberts, Jason A. and Fraser, John F. (2012). Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions. Critical Care and Resuscitation, 14 (2), 105-111.

Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions

Shekar, Kiran, Fung, Yoke L., Diab, Sara, Mullany, Daniel V., McDonald, Charles I., Dunster, Kimble R., Fisquet, Stephanie, Platts, David G., Stewart, David, Wallis, Steven C., Smith, Maree T., Roberts, Jason A. and Fraser, John F. (2012). Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions. Critical Care and Resuscitation, 14 (2), 105-111.

Development and validation of a sensitive solid-phase-extraction (SPE) method using high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) for determination of risedronate concentrations in human plasma

Ghassabian, Sussan, Wright, Linda A., deJager, Andrew D. and Smith, Maree T. (2012). Development and validation of a sensitive solid-phase-extraction (SPE) method using high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) for determination of risedronate concentrations in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 881-82, 34-41. doi: 10.1016/j.jchromb.2011.11.031

Pharmacogenetics of pain and analgesia

Smith, M. T. and Muralidharan, A. (2012). Pharmacogenetics of pain and analgesia. Clinical Genetics, 82 (4), 321-330. doi: 10.1111/j.1399-0004.2012.01936.x

Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation

Shekar, Kiran, Fraser, John F., Smith, Maree T. and Roberts, Jason A. (2012). Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation. Journal of Critical Care, 27 (6), 741.e9-741.e18. doi: 10.1016/j.jcrc.2012.02.013

Pain, analgesia and genetics

Muralidharan, Arjun and Smith, Maree T. (2011). Pain, analgesia and genetics. Journal of Pharmacy and Pharmacology, 63 (11), 1387-1400. doi: 10.1111/j.2042-7158.2011.01340.x

Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial

Gray, Paul, Kirby, Julie, Smith, Maree T., Cabot, Peter J., Williams, Bronwyn, Doecke, James and Cramond, Tess (2011). Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial. Pain, 152 (6), 1279-1288. doi: 10.1016/j.pain.2011.01.055

Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats

Otto, Kathleen J., Wyse, Bruce D., Cabot, Peter J. and Smith, Maree T. (2011). Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats. Pain Medicine, 12 (5), 782-793. doi: 10.1111/j.1526-4637.2011.01102.x

Longitudinal study of painful diabetic neuropathy in the Zucker diabetic fatty rat model of type 2 diabetes: Impaired basal G-protein activity appears to underpin marked morphine hyposensitivity at 6 months

Otto, Kathleen J., Wyse, Bruce D., Cabot, Peter J. and Smith, Maree T. (2011). Longitudinal study of painful diabetic neuropathy in the Zucker diabetic fatty rat model of type 2 diabetes: Impaired basal G-protein activity appears to underpin marked morphine hyposensitivity at 6 months. Pain Medicine, 12 (3), 437-450. doi: 10.1111/j.1526-4637.2011.01067.x

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

Dredge, K, Hammond, E, Handley, P, Gonda, TJ, Smith, MT, Vincent, C, Brandt, R, Ferro, V and Bytheway, I (2011). PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. British Journal of Cancer, 104 (5), 635-642. doi: 10.1038/bjc.2011.11

Pharmacogenetics

Smith, Maree T. and Muralidharan, Arjun (2010). Pharmacogenetics. Pain: Clinical Updates, 18 (8), 1-8.

A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin

Zin, Che S., Nissen, Lisa M., O'Callaghan, James P., Duffull, Stephen B., Smith, Maree T. and Moore, Brendan J. (2010). A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin. Journal of Pain, 11 (5), 462-471. doi: 10.1016/j.jpain.2009.09.003

Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management

Zin, Che S., Nissen, Lisa M., O'Callaghan, James P., Moore, Brendan J. and Smith, Maree T. (2010). Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management. Pain Medicine, 11 (4), 550-561. doi: 10.1111/j.1526-4637.2010.00821.x

X-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain

Brust, Andreas, Palant, Elka, Croker, Daniel E., Colless, Barbara, Drinkwater, Roger, Patterson, Brad, Schroeder, Christina I., Wilson, David, Nielsen, Carsten K., Smith, Maree T., Alewood, Danne, Alewood, Paul F and Lewis, Richard J. (2009). X-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. Journal of Medicinal Chemistry, 52 (22), 6991-7002. doi: 10.1021/jm9003413

Antinociception versus serum concentration relationships following acute administration of intravenous morphine in male and female Sprague-dawley rats: Differences between the tail flick and hot plate nociceptive tests

South, Samantha M., Edwards, Stephen R. and Smith, Maree T. (2009). Antinociception versus serum concentration relationships following acute administration of intravenous morphine in male and female Sprague-dawley rats: Differences between the tail flick and hot plate nociceptive tests. Clinical and Experimental Pharmacology and Physiology, 36 (1), 20-28. doi: 10.1111/j.1440-1681.2008.05019.x

Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A (2-17) following spinal and supraspinal routes of administration

Hemstapat, K., Le, L., Edwards, S. R. and Smith, M. T. (2009). Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A (2-17) following spinal and supraspinal routes of administration. Pharmacology, Biochemistry and Behaviour, 93 (4), 498-505. doi: 10.1016/j.pbb.2009.06.016

Innovation in drug development

Smith, M.T. (2009). Innovation in drug development. BioSpectrum Asia CRAMS Resources Guide, 52-53.

Differences between and combinations of opiods re-visited

Smith, Maree T. (2008). Differences between and combinations of opiods re-visited. Current Opinion in Anaesthesiology, 21 (5), 596-601. doi: 10.1097/ACO.0b013e32830a4c4a

An update on the pharmcological management of post-herpetic neuralgia and painful diabetic neuropathy

Zin, Che S., Nissen, Lisa M., Smith, Maree T., O'Callaghan, James P. and Moore, Brendan J. (2008). An update on the pharmcological management of post-herpetic neuralgia and painful diabetic neuropathy. CNS Drugs, 22 (5), 417-442. doi: 10.2165/00023210-200822050-00005

Sex differences in the pharmacokinetics, oxidative metabolism and oral bioactivity of oxycodone in the sprague-dawley rat

Chan, S., Edwards, S. R., Wyse, B. D. and Smith, M. T. (2008). Sex differences in the pharmacokinetics, oxidative metabolism and oral bioactivity of oxycodone in the sprague-dawley rat. Clinical and Experimental Pharmacology and Physiology, 35 (3), 295-302. doi: 10.1111/j.1440-1681.2007.04821.x

Studies with ketamine and alfentanil following Freund's complete adjuvant-induced inflammation in rats

Edwards, S. R., Mather, L. E. and Smith, M. T. (2007). Studies with ketamine and alfentanil following Freund's complete adjuvant-induced inflammation in rats. Clinical and Experimental Pharmacology and Physiology, 34 (5-6), 414-420. doi: 10.1111/j.1440-1681.2007.04581.x

Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry

Edwards, Stephen R. and Smith, Maree T. (2007). Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Chromatography B, 848 (2), 264-270. doi: 10.1016/j.jchromb.2006.10.039

Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain

Nielsen, Carsten K., Ross, Fraser B., Lotfipour, Shahrdad, Saini, Kamal S., Edwards, Stephen R. and Smith, Maree T. (2007). Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain. Pain, 132 (3), 289-300. doi: 10.1016/j.pain.2007.03.022

Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration

Smith, Maree T., Edwards, Stephen R. and Nielsen, Carsten K. (2007). Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration. Anesthesiology, 106 (5), 1063-1064. doi: 10.1097/01.anes.0000265176.75372.ed

Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain

Nielsen, Carsten K., Lewis, Richard J., Alewood, Dianne, Drinkwater, Roger, Palant, Elka, Patterson, Margaret, Yaksh, Tony L, McCumber, Damon and Smith, Maree T. (2005). Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain, 118 (1-2), 112-124. doi: 10.1016/j.pain.2005.08.002

Co-administration of oxycodone and morphine and analgesic synergy re-examined

Smith, MT and de la Iglesia, FA (2005). Co-administration of oxycodone and morphine and analgesic synergy re-examined. British Journal of Clinical Pharmacology, 59 (4), 486-487. doi: 10.1111/j.1365-2125.2005.02345_1.x

Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague-Dawley rats: Influence of streptozotocin-induced diabetes

Huang, L., Edwards, S. R. and Smith, M. T. (2005). Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague-Dawley rats: Influence of streptozotocin-induced diabetes. Pharmaceutical Research, 22 (9), 1489-1498. doi: 10.1007/s11095-005-6154-y

Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry

Edwards, S. R. and Smith, M. T. (2005). Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Chromatography B, 814 (2), 241-249. doi: 10.1016/j.jchromb.2004.10.035

Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions

Ladd, L. A., Kam, P. C., Williams, D. B., Wright, A. W. E., Smith, M. T. and Mather, L. E. (2005). Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions. British Journal of Clinical Pharmacology, 59 (5), 524-535. doi: 10.1111/j.1365-2125.2005.02368.x

Deletion of guanine nucleotide binding protein az subunit in mice induces a gene dose dependent tolerance to morphine

Leck, KJ, Bartlett, SE, Smith, MT, Megirian, D, Holgate, J, Powell, KL, Matthaei, KI and Hendry, IA (2004). Deletion of guanine nucleotide binding protein az subunit in mice induces a gene dose dependent tolerance to morphine. Neuropharmacology, 46 (6), 836-846. doi: 10.1016/j.neuropharm.2003.11.024

Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: Potential application to biomolecular screening

Hemstapat, K, Smith, M. T. and Monteith, G. R. (2004). Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: Potential application to biomolecular screening. Journal of Pharmacological and Toxicological Methods, 49 (2), 81-87. doi: 10.1016/j.vascn.2003.10.002

Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones

Hemstapat, K., Monteith, G. R., Smith, D. and Smith, M. T. (2003). Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones. Anesthesia & Analgesia, 97 (2), 494-505. doi: 10.1213/01.ANE.0000059225.40049.99

Managing diabetic neuropathy

Smith, M. T. (2003). Managing diabetic neuropathy. Australian Pharmacist, 22 (10), 782-787.

The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones

Hemstapat, K., Smith, S. A., Monteith, G. R. and Smith, M. T. (2003). The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones. Pharmacology & Toxicology, 93 (4), 197-200. doi: 10.1034/j.1600-0773.2003.930408.x

The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes

Wei, M., Ong, L., Smith, M. T., Ross, F. B., Schmid, K., Hoey, A., Burstow, D. J. and Brown, L. C. (2003). The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes. Heart, Lung and Circulation, 2003 (12), 44-50. doi: 10.1046/j.1444-2892.2003.00160.x

The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.

Smith, M. T., Cabot, P. J., Ross, F. B., Robertson, A. D. and Lewis, R. J. (2002). The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.. Pain, 96 (1-2), 119-127. doi: 10.1016/S0304-3959(01)00436-5

Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance

South, Samantha M., Wright, Andrew W. E., Lau, Michael, Mather, Laurence E. and Smith, Maree T. (2001). Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance. Journal of Pharmacology and Experimental Therapeutics, 297 (1), 446-457.

Analgesic tolerance to opioids

South, S. M. and Smith, M. T. (2001). Analgesic tolerance to opioids. Pain: Clinical Updates, 9 (5), 1-4.

Hydromorphone-3-glucuronide - A more potent neuro-excitant than its structural analogue, morphine-3-glucuronide

Wright, AWE, Mather, LE and Smith, MT (2001). Hydromorphone-3-glucuronide - A more potent neuro-excitant than its structural analogue, morphine-3-glucuronide. Life Sciences, 69 (4), 409-420. doi: 10.1016/S0024-3205(01)01133-X

Opioid analgesic prescribing and use - an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital

Nissen, L. M., Tett, S. E., Cramond, T., Williams, B. and Smith, M. T. (2001). Opioid analgesic prescribing and use - an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital. British Journal of Clinical Pharmacology, 52 (6), 693-698. doi: 10.1046/j.0306-5251.2001.01502.x

The role of morphine-6-glucuronide (M6G) in pain control

Smith, Maree T. and South, Samantha M. (2001). The role of morphine-6-glucuronide (M6G) in pain control. Pain Reviews, 8 (3-4), 171-191. doi: 10.1191/0968130201pr183ra

Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats

Ross, Fraser B., Wallis, Steven C. and Smith, Maree T. (2000). Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats. Pain, 84 (2-3), 421-428. doi: 10.1016/S0304-3959(99)00230-4

Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat

Nielsen, C. K., Ross, F. B. and Smith, M. T. (2000). Incomplete, asymmetric, and route-dependent cross-tolerance between oxycodone and morphine in the Dark Agouti rat. Journal of Pharmacology and Experimental Therapeutics, 295 (1), 91-99.

Neuroexcitatory effects of morphine and hydromorphone: Evidence implicating the 3-glucuronide metabolites

Smith, MT (2000). Neuroexcitatory effects of morphine and hydromorphone: Evidence implicating the 3-glucuronide metabolites. Clinical and Experimental Pharmacology and Physiology, 27 (7), 524-528. doi: 10.1046/j.1440-1681.2000.03290.x

Systemic coadministration of chloramphenicol with intravenous but not intracerebroventricular morphine markedly increases morphine antinociception and delays development of antinociceptive tolerance in rats

Smith, M. T., Nielsen, C. K., Lim-Fraser, M. Y. C., Wright, A. W. E. and Lau, M. (2000). Systemic coadministration of chloramphenicol with intravenous but not intracerebroventricular morphine markedly increases morphine antinociception and delays development of antinociceptive tolerance in rats. Drug Metabolism And Disposition, 28 (2), 236-244.

Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide

Halliday, Andrew J., Bartlett, Selena E., Colditz, Paul and Smith, Maree T. (1999). Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide. Life Sciences, 65 (2), 225-236. doi: 10.1016/S0024-3205(99)00239-8

Cerebrospinal fluid and plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in patients before and after initiation of intracerebroventricular morphine for cancer pain management

Smith, M. T., Wright, A. W., Williams, B., Stuart, G. and Cramond, T. R. (1999). Cerebrospinal fluid and plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in patients before and after initiation of intracerebroventricular morphine for cancer pain management. Anesthesia and analgesia, 88 (1), 109-116. doi: 10.1097/00000539-199901000-00021

Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis

Keates, Helen L., Cramond, Teresa and Smith, Maree T. (1999). Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis. Anesthesia and Analgesia, 89 (2), 409-415.

Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis

Keates, HL, Cramond, T and Smith, MT (1999). Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis. Anesthesia and Analgesia, 89 (2), 409-415. doi: 10.1097/00000539-199908000-00030

The excitatory behavioral and antianalgesic pharmacology of normorphine- 3-glucuronide after intracerebroventricular administration to rats

Smith, Gregg D. and Smith, Maree T. (1998). The excitatory behavioral and antianalgesic pharmacology of normorphine- 3-glucuronide after intracerebroventricular administration to rats. Journal of Pharmacology and Experimental Therapeutics, 285 (3), 1157-1162.

Apparent insensitivity of the hotplate latency test for detection of antinociception following intraperitoneal, intravenous or intracerebroventricular M6G administration to rats

South, SM and Smith, MT (1998). Apparent insensitivity of the hotplate latency test for detection of antinociception following intraperitoneal, intravenous or intracerebroventricular M6G administration to rats. Journal of Pharmacology And Experimental Therapeutics, 286 (3), 1326-1332.

Hydromorphone-3-glucuronide: Biochemical synthesis and preliminary pharmacological evaluation

Wright, AWE, Nocente, ML and Smith, MT (1998). Hydromorphone-3-glucuronide: Biochemical synthesis and preliminary pharmacological evaluation. Life Sciences, 63 (5), 401-411. doi: 10.1016/S0024-3205(98)00288-4

Improved one-step solid-phase extraction method for morphine, morphine-3-glucuronide, and morphine-6-glucuronide from plasma and quantitation using high-performance liquid chromatography with electrochemical detection

Wright, AWE and Smith, MT (1998). Improved one-step solid-phase extraction method for morphine, morphine-3-glucuronide, and morphine-6-glucuronide from plasma and quantitation using high-performance liquid chromatography with electrochemical detection. Therapeutic Drug Monitoring, 20 (2), 215-218. doi: 10.1097/00007691-199804000-00013

Investigation of the antinociceptive efficacy and relative potency of extended duration injectable 3-acylmorphine-6-sulfate prodrugs in rats

Preechagoon, D, Smith, MT and Prankerd, RJ (1998). Investigation of the antinociceptive efficacy and relative potency of extended duration injectable 3-acylmorphine-6-sulfate prodrugs in rats. International Journal of Pharmaceutics, 163 (1-2), 191-201. doi: 10.1016/S0378-5173(97)00380-3

Solid-phase extraction method with high-performance liquid chromatography and electrochemical detection for the quantitative analysis of oxycodone in human plasma

Wright, AWE, Lawrence, JA, Iu, M, Cramond, T and Smith, MT (1998). Solid-phase extraction method with high-performance liquid chromatography and electrochemical detection for the quantitative analysis of oxycodone in human plasma. Journal of Chromatography B, 712 (1-2), 169-175. doi: 10.1016/S0378-4347(98)00146-7

The excitatory behavioral and antianalgesic pharmacology of normorphine-3-glucuronide after intracerebroventricular administration to rats

Smith, GD and Smith, MT (1998). The excitatory behavioral and antianalgesic pharmacology of normorphine-3-glucuronide after intracerebroventricular administration to rats. Journal of Pharmacology And Experimental Therapeutics, 285 (3), 1157-1162.

Biochemical synthesis, purification and preliminary pharmacological evaluation of normorphine-3-glucuronide

Smith, GD, Prankerd, RJ and Smith, MT (1997). Biochemical synthesis, purification and preliminary pharmacological evaluation of normorphine-3-glucuronide. Life Sciences, 61 (2), 95-104. doi: 10.1016/S0024-3205(97)00364-0

Morphine has a dual concentration-dependent effect on K+-evoked substance P release from rat peripheral airways

Cabot, PJ, Cramond, T and Smith, MT (1997). Morphine has a dual concentration-dependent effect on K+-evoked substance P release from rat peripheral airways. Pulmonary Pharmacology & Therapeutics, 10 (4), 215-221. doi: 10.1006/pupt.1997.0094

The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated

Ross, FB and Smith, MT (1997). The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated. Pain, 73 (2), 151-157. doi: 10.1016/S0304-3959(97)00093-6

Quantitative autoradiography of peripheral opioid binding sites in rat lung

Cabot, PJ, Cramond, T and Smith, MT (1996). Quantitative autoradiography of peripheral opioid binding sites in rat lung. European Journal of Pharmacology, 310 (1), 47-53. doi: 10.1016/0014-2999(96)00363-9

Effects of morphine-3-glucuronide and morphine on the K+-evoked release of [H-3]-glutamic acid and [C-14]-gamma-aminobutyric acid from rat brain synaptosomes

Bartlett, SE and Smith, MT (1995). Effects of morphine-3-glucuronide and morphine on the K+-evoked release of [H-3]-glutamic acid and [C-14]-gamma-aminobutyric acid from rat brain synaptosomes. Life Sciences, 58 (5), 447-454. doi: 10.1016/0024-3205(95)02310-0

The Apparent Affinity of Morphine-3-Glucuronide At Mu(1)-Opioid Receptors Results From Morphine Contamination - Demonstration Using Hplc and Radioligand Binding

Bartlett, SE and Smith, MT (1995). The Apparent Affinity of Morphine-3-Glucuronide At Mu(1)-Opioid Receptors Results From Morphine Contamination - Demonstration Using Hplc and Radioligand Binding. Life Sciences, 57 (6), 609-615.

Morphine-3-glucuronide: evidence to support its putative role in the development of tolerance to the antinociceptive effects of morphine in the rat

Smith G.D. and Smith M.T. (1995). Morphine-3-glucuronide: evidence to support its putative role in the development of tolerance to the antinociceptive effects of morphine in the rat. Pain, 62 (1), 51-60. doi: 10.1016/0304-3959(94)00228-7

Pharmacokinetics and pharmacodynamics of oxycodone when given intravenously and rectally to adult patients with cancer pain

Leow, KP, Cramond, T and Smith, MT (1995). Pharmacokinetics and pharmacodynamics of oxycodone when given intravenously and rectally to adult patients with cancer pain. Anesthesia and Analgesia, 80 (2), 296-302. doi: 10.1097/00000539-199502000-00016

UNTITLED - COMMENTS

SMITH, M and CRAMOND, T (1994). UNTITLED - COMMENTS. Pain, 59 (1), 155-156. doi: 10.1016/0304-3959(94)90065-5

Pharmacology of Morphine and Morphine-3-Glucuronide At Opioid, Excitatory Amino-Acid, Gaba and Glycine Binding-Sites

Bartlett, SE, Dodd, PR and Smith, MT (1994). Pharmacology of Morphine and Morphine-3-Glucuronide At Opioid, Excitatory Amino-Acid, Gaba and Glycine Binding-Sites. Pharmacology & Toxicology, 75 (2), 73-81. doi: 10.1111/j.1600-0773.1994.tb00327.x

Characterization of Nonconventional Opioid Binding-Sites in Rat and Human Lung

Cabot, PJ, Dodd, PR, Cramond, T and Smith, MT (1994). Characterization of Nonconventional Opioid Binding-Sites in Rat and Human Lung. European Journal of Pharmacology-Molecular Pharmacology Section, 268 (2), 247-255. doi: 10.1016/0922-4106(94)90195-3

Quantitation of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide in Plasma and Cerebrospinal-Fluid Using Solid-Phase Extraction and High-Performance Liquid-Chromatography with Electrochemical Detection

Wright, Awe, Watt, JA, Kennedy, M, Cramond, T and Smith, MT (1994). Quantitation of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide in Plasma and Cerebrospinal-Fluid Using Solid-Phase Extraction and High-Performance Liquid-Chromatography with Electrochemical Detection. Therapeutic Drug Monitoring, 16 (2), 200-208. doi: 10.1097/00007691-199404000-00016

The Antinociceptive Potencies of Oxycodone, Noroxycodone and Morphine After Intracerebroventricular Administration to Rats

Leow, KP and Smith, MT (1994). The Antinociceptive Potencies of Oxycodone, Noroxycodone and Morphine After Intracerebroventricular Administration to Rats. Life Sciences, 54 (17), 1229-1236. doi: 10.1016/0024-3205(94)00849-3

The antinociceptive potencies of oxycodone, noroxycodone and morphine after intracerebroventricular administration to rats

Leow, K P and Smith, M T (1994). The antinociceptive potencies of oxycodone, noroxycodone and morphine after intracerebroventricular administration to rats. Life sciences, 54 (17), 1229-36.

The excitatory effects of morphine-3-glucuronide are attenuated by LY274614, a competitive NMDA receptor antagonist, and by midazolam, an agonist at the benzodiazepine site on the GABAA receptor complex

Bartlett, SE, Cramond, T and Smith, MT (1994). The excitatory effects of morphine-3-glucuronide are attenuated by LY274614, a competitive NMDA receptor antagonist, and by midazolam, an agonist at the benzodiazepine site on the GABAA receptor complex. Life Sciences, 54 (10), 687-694. doi: 10.1016/0024-3205(94)00552-4

Determination of the Serum-Protein Binding of Oxycodone and Morphine Using Ultrafiltration

Leow, KP, Wright, Awe, Cramond, T and Smith, MT (1993). Determination of the Serum-Protein Binding of Oxycodone and Morphine Using Ultrafiltration. Therapeutic Drug Monitoring, 15 (5), 440-447. doi: 10.1097/00007691-199310000-00014

Comparative Oxycodone Pharmacokinetics in Humans After Intravenous, Oral, and Rectal Administration

Leow, KP, Smith, MT, Watt, JA, Williams, BE and Cramond, T (1992). Comparative Oxycodone Pharmacokinetics in Humans After Intravenous, Oral, and Rectal Administration. Therapeutic Drug Monitoring, 14 (6), 479-484. doi: 10.1097/00007691-199212000-00008

Single-Dose and Steady-State Pharmacokinetics and Pharmacodynamics of Oxycodone in Patients with Cancer

Leow, KP, Smith, MT, Williams, B and Cramond, T (1992). Single-Dose and Steady-State Pharmacokinetics and Pharmacodynamics of Oxycodone in Patients with Cancer. Clinical Pharmacology & Therapeutics, 52 (5), 487-495. doi: 10.1038/clpt.1992.176

Comments on Gong et al., PAIN, 48 (1992) 249-255

Cramond, Tess, Smith, Maree T. and Watt, Julie A. (1992). Comments on Gong et al., PAIN, 48 (1992) 249-255. Pain, 51 (1), 124-125. doi: 10.1016/0304-3959(92)90022-4

Quantitation of oxycodone in human plasma using high–performance liquid chromatography with electrochemical detection

Smith M.T., Watt J.A., Mapp G.P. and Cramond T. (1991). Quantitation of oxycodone in human plasma using high–performance liquid chromatography with electrochemical detection. Therapeutic Drug Monitoring, 13 (2), 126-130. doi: 10.1097/00007691-199103000-00007

Dose-dependent pharmacokinetics of caffeine in humans: Relevance as a test of quantitative liver function

Cheng W.S.C., Murphy T.L., Smith M.T., Cooksley W.G.E., Halliday J.W. and Powell L.W. (1990). Dose-dependent pharmacokinetics of caffeine in humans: Relevance as a test of quantitative liver function. Clinical Pharmacology and Therapeutics, 47 (4), 516-524. doi: 10.1038/clpt.1990.66

Morphine-3-glucuronide - a potent antagonist of morphine analgesia

Smith M.T., Watt J.A. and Cramond T. (1990). Morphine-3-glucuronide - a potent antagonist of morphine analgesia. Life Sciences, 47 (6), 579-585. doi: 10.1016/0024-3205(90)90619-3

Correlations between in vitro dissolution, in vivo bioavailability and hypoglycaemic effect of oral glibenclamide

Chalk, J.B., Patterson, M., Smith, M.T. and Eadie, M.J. (1986). Correlations between in vitro dissolution, in vivo bioavailability and hypoglycaemic effect of oral glibenclamide. European Journal of Clinical Pharmacology, 31 (2), 177-182. doi: 10.1007/BF00606655

A sensitive liquid chromatographic assay for plasma aspirin and salicylate concentrations after low doses of aspirin

Brandon R.A., Eadie M.J. and Smith M.T. (1985). A sensitive liquid chromatographic assay for plasma aspirin and salicylate concentrations after low doses of aspirin. Therapeutic Drug Monitoring, 7 (2), 216-221. doi: 10.1097/00007691-198506000-00014

Organ and tissue preservation for transplantation: Monitoring by 31P nuclear magnetic resonance

Marshall V., Ross B., Smith M., Bartlett S. and Freeman D. (1985). Organ and tissue preservation for transplantation: Monitoring by 31P nuclear magnetic resonance. Transplantation Proceedings, 17 (2), 1693-1696.

Bioavailability and pharmacokinetics of phenytoin during pregnancy

Lander C.M., Smith M.T., Chalk J.B., de Wytt C., Symoniw P., Livingstone I. and Eadie M.J. (1984). Bioavailability and pharmacokinetics of phenytoin during pregnancy. European Journal of Clinical Pharmacology, 27 (1), 105-110. doi: 10.1007/BF00553163

Pharmacokinetics of midazolam in the aged

Smith M.T., Heazlewood V., Eadie M.J., Brophy T.O. and Tyrer J.H. (1984). Pharmacokinetics of midazolam in the aged. European Journal of Clinical Pharmacology, 26 (3), 381-388. doi: 10.1007/BF00548771

Chronic propranolol administration during pregnancy - Maternal pharmacokinetics

Smith, MT, Livingstone, I, Eadie, MJ, Hooper, WD and Triggs, EJ (1983). Chronic propranolol administration during pregnancy - Maternal pharmacokinetics. European Journal of Clinical Pharmacology, 25 (4), 481-490. doi: 10.1007/BF00542115

Metabolism of propranolol in the human maternal-placental-foetal unit

Smith, MT, Livingstone, I, Eadie, MJ, Hooper, WD and Triggs, EJ (1983). Metabolism of propranolol in the human maternal-placental-foetal unit. European Journal of Clinical Pharmacology, 24 (6), 727-732. doi: 10.1007/BF00607078

Propranolol in pregnancy three year prospective study

Livingstone I., Craswell P.W., Bevan E.B., Smith M.T. and Eadie M.J. (1983). Propranolol in pregnancy three year prospective study. Hypertension in Pregnancy, B2 (2), 341-350. doi: 10.3109/10641958309006092

Propranolol, Propranolol Glucuronide, and Naphthoxylactic Acid in Breast-Milk and Plasma

Smith, MT, Livingstone, I, Hooper, WD, Eadie, MJ and Triggs, EJ (1983). Propranolol, Propranolol Glucuronide, and Naphthoxylactic Acid in Breast-Milk and Plasma. Therapeutic Drug Monitoring, 5 (1), 87-93. doi: 10.1097/00007691-198303000-00008

Novel Source of Ubiquitous Phthalates as Analytical Contaminant

Hooper, WD and Smith, MT (1981). Novel Source of Ubiquitous Phthalates as Analytical Contaminant. Journal of Pharmaceutical Sciences, 70 (3), 346-347. doi: 10.1002/jps.2600700337

The pharmacokinetics of midazolam in man

Smith, MT, Eadie, MJ and Brophy, TO (1981). The pharmacokinetics of midazolam in man. European Journal of Clinical Pharmacology, 19 (4), 271-278. doi: 10.1007/BF00562804

The unsteady model - An alternative approach to nonlinear pharmacokinetics

Smith M.T. and Smith T.C. (1981). The unsteady model - An alternative approach to nonlinear pharmacokinetics. European Journal of Clinical Pharmacology, 20 (5), 387-398. doi: 10.1007/BF00615410

The pharmacokinetics of midazolam in man

Smith, M. T., Eadie, M. J., O'Rourke-Brophy, T. and Smith, T. C. (1980). The pharmacokinetics of midazolam in man. Clinical and Experimental Pharmacology and Physiology, 7 (6)

Pharmacokinetics of prazepam in man

Smith, MT, Evans, Lej, Eadie, MJ and Tyrer, JH (1979). Pharmacokinetics of prazepam in man. European Journal of Clinical Pharmacology, 16 (2), 141-147. doi: 10.1007/BF00563121

In vivo biodistribution of the nitric oxide donor, PRG150, using PET imaging in rats

Pippin, Adam, Voll, Ronald, Liotta, Dennis, Smith, Maree and Goodman, Mark (2016). In vivo biodistribution of the nitric oxide donor, PRG150, using PET imaging in rats. RESTON: SOC NUCLEAR MEDICINE INC.

Analgesic efficacy and mode of action of small molecule Angiotensin II type 2 receptor (AT2R) antagonists for neuropathic and inflammatory pain

Smith, Maree, Muralidharan, Arjun and Praveen, Anand (2014). Analgesic efficacy and mode of action of small molecule Angiotensin II type 2 receptor (AT2R) antagonists for neuropathic and inflammatory pain. 34 th Annual Scientific Meeting of the Australian Pain Society, Hobart , Australia, 13 - 16 April 2014.

Development and validation of an lc-ms/ms bioanalytical method for quantification of homocysteine (hcy) in samples of human serum

Ghassabian, Sussan, Rethwan, Ahmad, Griffiths, Lyn and Smith, Maree (2014). Development and validation of an lc-ms/ms bioanalytical method for quantification of homocysteine (hcy) in samples of human serum. International Pharmaceutical Federation (FIP), Melbourme, Australia, 13-16 April 2014.

Establishment of a rat model of low back pain

Muralidharan, Arjun and Smith, Maree (2014). Establishment of a rat model of low back pain. 15th World Congress on Pain, Buenos Aires, Argentina, 6 - 11 October 2014.

Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation may cause therapeutic failure

Shekar, K., Diab, S., McDonald, C., Fisquet, S., Dunster, K., Fung, L., Platts, D., Ghassabian, S., Barnett, A., Roberts, J., Smith, M. and Fraser, J. (2012). Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation may cause therapeutic failure. Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Brisbane, QLD, Australia, 16-19 August 2012. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2012.05.581

Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation may cause therapeutic failure

Shekar, K., Mcdonald, C., Fisquet, S., Barnett, A., Ghassabian, S., Fung, L., Roberts, J., Smith, M. and Fraser, J. (2012). Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation may cause therapeutic failure. Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meetin, Brisbane, QLD Australia, 16-19 August 2012. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2012.05.584

Is morphine superior to fentanyl for analgesia during extracorporeal membrane oxygenation in adult patients?

Shekar, K., Mcdonald, C., Fisquet, S., Barnett, A., Ghassabian, S., Fung, L., Roberts, J., Smith, M. and Fraser, J. (2012). Is morphine superior to fentanyl for analgesia during extracorporeal membrane oxygenation in adult patients?. Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Brisbane, QLD Australia, 16-19 August 2012. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2012.05.585

A behavioural study assessing memory deficits in the APP/PS1 double transgenic mouse model of Alzheimer’s disease using the Morris water maze.

Edwards, Stephen R., Coulson, Elizabeth J. and Smith, Maree T. (2010). A behavioural study assessing memory deficits in the APP/PS1 double transgenic mouse model of Alzheimer’s disease using the Morris water maze.. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) 44th Annual Scientific Meeting 2010, Melbourne, Australia, 28 November-1 December 2010. Melbourne, Australia: ASCEPT.

A study of the application of the Morris water maze to the establishment of a preclinical model of Alzheimer's disease in the rat

Edwards, Stephen and Smith, M.T. (2009). A study of the application of the Morris water maze to the establishment of a preclinical model of Alzheimer's disease in the rat. ASCEPT 43rd Annual Scientific Meeting 2009: The Rights of Medicines, Darling Harbour, NSW, Australia, 29 November-2 December 2009.

DEVELOPMENT OF XEN2174: NON-CLINICAL STUDIES AND AN OPEN-LABEL I/IIa STUDY OF INTRATHECAL USE IN ONCOLOGY PATIENTS WITH MODERATE TO SEVERE PAIN

Martin, W., Lewis, R. J., Palant, E., Brust, A., Colless, B., Schmidt, P., Drinkwater, R., Stearns, L. J., Cousins, M., Gouke, R., Hughes, D., Rauck, R., Day, D., Nielsen, C. K. and Smith, M. T. (2009). DEVELOPMENT OF XEN2174: NON-CLINICAL STUDIES AND AN OPEN-LABEL I/IIa STUDY OF INTRATHECAL USE IN ONCOLOGY PATIENTS WITH MODERATE TO SEVERE PAIN. 21st American Peptide Symposium, Bloomington in, Jun 07-12, 2009. HOBOKEN: JOHN WILEY & SONS INC.

Development of XEN2174 and an escalating safety and tolerability study of intrathecal use in oncology patients

Brust, A., Colless, B., Cousins, M., Day, D., Drinkwater, R., Gouke, R., Hughes, D., Lewis, R. J., Martin, W., Nielson, C., Palant, E., Rauck, R., Schmidt, P., Smith, M. T. and Steams, L. J. (2009). Development of XEN2174 and an escalating safety and tolerability study of intrathecal use in oncology patients. Michal Lebl Peptides Breaking Away, Bloomington, Indiana, U.S.A., 7-12 June, 2009. San Diego, C.A. U.S.A.: American Peptide Society.

High-quality, cost-effective preclinical product development solutions

Smith, Maree (2009). High-quality, cost-effective preclinical product development solutions. BIO Korea 2009, Seoul, Korea, 16-18 September 2009. Seoul, Korea: BIO Korea 2009.

Comparative profiles of the antinociceptive and constipating effects of single intracerebroventricular (i.c.v.) bolus doses of morphine and oxycodone in rats

Kuo, A., Hemstapat, K., Wyse, B. D., South, S. M. and Smith, M. T. (2008). Comparative profiles of the antinociceptive and constipating effects of single intracerebroventricular (i.c.v.) bolus doses of morphine and oxycodone in rats. 12th World Congress on Pain, Glasgow, UK, 17-22 August 2008.

Comparative profiles of the antinociceptive and constipating effects of single intracerebroventricular (i.c.v.) bolus doses of morphine, morphine-6-glucuronide and fentanyl in rats Kuo A, Hemstapat K, Wyse BD, Smith MT

Hemstapat, K., Kuo, A., Smith, M.T. and Wyse, B.D. (2008). Comparative profiles of the antinociceptive and constipating effects of single intracerebroventricular (i.c.v.) bolus doses of morphine, morphine-6-glucuronide and fentanyl in rats Kuo A, Hemstapat K, Wyse BD, Smith MT. 4th Scientific Meeting of the Australian Health and Medical Research Congress, Brisbane, Australia, 16 - 21 November, 2008.

Development of novel X-conopeptide inhibitors of the norepinephrine transporter with analgesic potential

Lewis, R. J., Palant, E., Brust, A., Colless, B., Schmidt, P., Nielsen, C. K., Smith, M. T. and Drinkwater, R. (2008). Development of novel X-conopeptide inhibitors of the norepinephrine transporter with analgesic potential. 12th World Congress on Pain, Glasgow, Scotland, 17-22 August, 2008.

Efficacy of Pregabalin And Oxycodone in patients with post-herpetic neuralgia or painful diabetic neuropathy

Zin, Che Suraya, Nissen, Lisa, Smith, Maree, O'Callaghan, James and Moore, Brendan (2008). Efficacy of Pregabalin And Oxycodone in patients with post-herpetic neuralgia or painful diabetic neuropathy. 28th Annual Scientific Meeting of the Australian Pain Society, Perth Western Australian, 30 March - 2 April 2008.

Influence of diet on the longitudinal temporal development of opioid hyposensitivity and tactile allodynia in the Zucker Diabetic Fatty (ZDF) rat

Otto, K., Wyse, B. D., South, S. M., Cabot, P. J. and Smith, M. T. (2008). Influence of diet on the longitudinal temporal development of opioid hyposensitivity and tactile allodynia in the Zucker Diabetic Fatty (ZDF) rat. 12th World Congress on Pain, Glasgow, Scotland, 17-22 August 2008.

Influence of diet on the longitudinal temporal development of opioid hyposensitivity and tactile allodynia in the Zucker Diabetic Fatty (ZDF) rat

Cabot, P.J., Otto, K., Smith, M.T., South, S.M. and Wyse, B.D. (2008). Influence of diet on the longitudinal temporal development of opioid hyposensitivity and tactile allodynia in the Zucker Diabetic Fatty (ZDF) rat. 28th Annual Scientific Meeting of the Australian Pain Society: The Spectrum of Pain, Perth, Australia, 30 March – 2 April, 2008.

Mechanistic insight into the anti-allodynic effects of PRG100

Huang, L., Smith, M. T. and Wyse, B. D. (2008). Mechanistic insight into the anti-allodynic effects of PRG100. 12th World Congress on Pain, Glasgow, Scotland, U. K., 17-22 August 2008. IASP Press.

Mechanistic insight into the anti-allodynic effects of PRG150

Huang, L., Wyse, B. D. and Smith, M. T. (2008). Mechanistic insight into the anti-allodynic effects of PRG150. 12th World Congress on Pain, Glasgow, Scotland, 17-22 August 2008.

Novel strategies in new opioid analgesic development

Smith, M. T. (2008). Novel strategies in new opioid analgesic development. Combined CME Spring Meeting of Faculty of Pain Medicine, ANZCA, Acute Pain special Interest Group of ANZCA, ASA and NZSA, Acute Pain Special Interest Group of IASP, Ayers Rock, Northern Territory, Australia, 18-20 September 2008.

Opioid-induced hyperalgesia, opioid rotation and opioid combinations

Smith, Maree T. (2008). Opioid-induced hyperalgesia, opioid rotation and opioid combinations. Combined CME Spring Meeting of Faculty of Pain Medicine, ANZCA, Acute Pain special Interest Group of ANZCA, ASA and NZSA, Acute Pain Special Interest Group of IASP: Pain at the Centre, Ayers Rock, Australia, 18-20 September 2008.

Preclinical development of new drugs for pain treatment

Smith, M. T. (2008). Preclinical development of new drugs for pain treatment. 4th Australian Health and Medical Research Congress, Brisbane, Australia, 16-21 November 2008. Brisbane, Australia:

Taking the pain out of research

Smith, M. T., Williamson, O. and Farrell, M. (2008). Taking the pain out of research. 28th Annual Scientific Meeting of the Australian Pain Society, Perth, Australia, 30 March - 2 April, 2008.

Treating post-herpetic neuralgia or painful diabetic neuropathy with a combination of pregabalin and oxycodone: A randomized controlled trial

Moore, B. J., Zin, C. S., Nissen, L. M., O'Callaghan, J. P. and Smith, M. T. (2008). Treating post-herpetic neuralgia or painful diabetic neuropathy with a combination of pregabalin and oxycodone: A randomized controlled trial. 12th World Congress on Pain, Glasgow, Scotland, 17-22 August, 2008.

2',3'-Dideoxycytidine-Induced Neuropathy: Comparison With Other Neuropathic Pain Models

Wyse, B., Rogers, H., O'Hagan, S., Dao, C. B., Weerasinghe, G., Smith, M. T. and South, S. M. (2007). 2',3'-Dideoxycytidine-Induced Neuropathy: Comparison With Other Neuropathic Pain Models. 41st Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists, Adelaide South Australia, 2-6 December 2007.

A randomized control trial of pregabalin and oxycodone in post herpetic neuralgia and painful diabetic neuropathy

Moore, B. J., Nissen, L. M., O'Callaghan, J. P., Smith, M. T. and Zin, C. S. (2007). A randomized control trial of pregabalin and oxycodone in post herpetic neuralgia and painful diabetic neuropathy. 41st Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and 10th Southeast Asian SEAWP-RMP Joint meeting 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists with HBPRCA, Adelaide, South Australia, 2 - 6 December, 2007. Victoria, Australia: ASCEPT.

Additive Antinociception Following Co-administration of a NR2B-Selective NMDA Antagonist with BDNF

South, S. M., Dao, C. B., Wyse, B. and Smith, M. T. (2007). Additive Antinociception Following Co-administration of a NR2B-Selective NMDA Antagonist with BDNF. 41st Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists, Adelaide, South Australia, 2-6 December 2007.

Co-administration of pregabalin and oxycodone for the treatment of neuropathic pain: A randomized double-blind, placebo-controlled, parallel-group study

Zin, Che Surava, Smith, Maree, Moore, Brendan, O'Callaghan, James and Nissen, Lisa (2007). Co-administration of pregabalin and oxycodone for the treatment of neuropathic pain: A randomized double-blind, placebo-controlled, parallel-group study. Annual Conference of the Australasian Pharmaceutical Science Association, Sydney, 8-11 December 2007.

Influence of diet on the temporal development of tactile allodynia and opioid hyposensitivity for 22-wks in the Zucker Diabetic Fatty (ZDF) rat

Cabot, P. J., Otto, K. J., Smith, M. T., South, S. M. and Wyse, B. D. (2007). Influence of diet on the temporal development of tactile allodynia and opioid hyposensitivity for 22-wks in the Zucker Diabetic Fatty (ZDF) rat. Second International Congress on Neuropathic Pain, Berlin, Germany, 7- 10 June 2007. Berlin, Germany: doi: 10.1016/j.ejpain.2007.03.177

Modelling Parkinson's Disease in rats

Smith, M. T., Wyse, B., Hall, H., Moisan, A., LeMontagne, S., Wolliez, A., Weerasinghe, G. and South, S. M. (2007). Modelling Parkinson's Disease in rats. 41st Annual Scientific Meeting of Australian Society of Clinical and Experimental Pharmacologists and Toxicologists & South-East Asian Western Pacific Regional Meeting of Pharmacologists, Adelaide, Australia, 2-6 December 2007.

Possible mechanism of action for neuroprotective effect of fucoidin in A-beta-induced Alzheimer's disease model

Patel, A., South, S. M., Smith, M. T. and Cabot, P. J. (2007). Possible mechanism of action for neuroprotective effect of fucoidin in A-beta-induced Alzheimer's disease model. Neuroscience 2007, San Diego, U.S., 3-7 November, 2007. Society for Neuroscience.

The APS/APRA PhD Scholarship Scheme: Basic and clinical science research targeted to improving patient outcomes

Smith, M. T. (2007). The APS/APRA PhD Scholarship Scheme: Basic and clinical science research targeted to improving patient outcomes. 27th Annual Scientific Meeting of the Australian Pain Society (IASP Chapter): The Torture of Pain: Crossing cultural barriers in Australia, Asia and beyond, Adelaide, Australia, 1-4 April 2007.

(PK)PD of the anti-allodynic effects of gabapentin and oxycodone in a neuropathic pain rodent model

Tan, S., Duffull, S B and Smith, M T (2006). (PK)PD of the anti-allodynic effects of gabapentin and oxycodone in a neuropathic pain rodent model. PAGANZ 06, Auckland, New Zealand / School of Medicine, 7-9 Feburary, 2006. New Zealand: Population Approach Group in Australia and New Zealand.

Assessment of fucoidin efficacy in a beta-peptide induced in Alzheimer's disease model

Patel, A., Smith, M. T., South, S. M. and Cabot, P. J. (2006). Assessment of fucoidin efficacy in a beta-peptide induced in Alzheimer's disease model. Neuroscience 2006, Atlanta, Geogia / Georgia World Congress Center, 14-18 October 2006. USA: Society for Neuroscience.

Combining opioids - Preclinical and clinical studies

Smith, M. T. (2006). Combining opioids - Preclinical and clinical studies. 7th Biennial Conference of the Australian and New Zealand Society of Palliative Medicine, Newcastle, 4-6 October 2006. Newcastle: Australian and New Zealand Society of Palliative Medicine.

Insulin implants prevent the temporal development of tactile allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats

Otto, K. J., Wyse, B. D., Cabot, P. J. and Smith, M. T. (2006). Insulin implants prevent the temporal development of tactile allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats. 26th Annual Scientific Meeting of the Australian Pain Society, Melbourne / Grand Hyatt Hotel, 9-12 April 2006. Melbourne: Australian Pain Society.

PRG100, a novel anti-allodynic agent

Tsui, D. Y. Y., Wyse, B. D., Monteith, G. R. and Smith, M. T. (2006). PRG100, a novel anti-allodynic agent. 26th Annual Scientific Meeting of the Australian Pain Society, Melbourne, Australia, 9-12 April, 2006. Victoria, Australia: Australian Pain Society.

Preliminary evaluation of cultured embryonic rat midbrain neurons as an in vitro model of diabetic neuropathy

Tsui, D. Y., Monteith, G. R., Wyse, B. D. and Smith, M. T. (2006). Preliminary evaluation of cultured embryonic rat midbrain neurons as an in vitro model of diabetic neuropathy. 11th World Congress on Pain, Sydney, Australia, 21-26 August 2005. Seattle, Wa.: IASP Press.

Retrospective drug utilisation evaluation of gabapentin for the treatment of neuropathic pain by the Multidiscplinary Pain Centre, Royal Brisbane and Women's Hospital

Ko, E., Cramond, T R O, Smith, M T and Cabot, P J (2006). Retrospective drug utilisation evaluation of gabapentin for the treatment of neuropathic pain by the Multidiscplinary Pain Centre, Royal Brisbane and Women's Hospital. 2006 Conference of the Queensland Branch of the Society for Hospital Pharmacists of Australia, Carlton Crest / Brisbane, October 2006.

The novel compound PRG100 reverses tactile allodynia in STZ-induced diabetic rats

Tsui, D. Y. Y., Wyse, B D and Smith, M T (2006). The novel compound PRG100 reverses tactile allodynia in STZ-induced diabetic rats. 2006 Neuroscience Meeting, Atlanta, 14-18 October, 2006. Atlanta: Society for Neuroscience.

Update on opioids receptors

Smith, M. T. (2006). Update on opioids receptors. 7th Biennial Conference of the Australian and New Zealand Society of Palliative Medicine, Newcastle, 4-6 October 2006. Newcastle: Australian and New Zealand Society of Palliative Medicine.

Antihyperalgesic and anti-inflammatory effects of RS- & S-ketamine in freunds complete adjuvant (FCA)-induced inflammation

Edwards, S. R., Mather, L. E. and Smith, M. T. (2005). Antihyperalgesic and anti-inflammatory effects of RS- & S-ketamine in freunds complete adjuvant (FCA)-induced inflammation. 11th World Congress on Pain, Sydney, 21-26 August 2005. USA: IASP Press.

Assessment of fucoidin efficacy in Ab-peptide induced Alzheimer's disease model

Patel, A., Smith, M. T., South, S. M. and Cabot, P. J. (2005). Assessment of fucoidin efficacy in Ab-peptide induced Alzheimer's disease model. Joint Meeting of ASCEPT and APSA, Melbourne, 4-7 December 2005. Australia: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists.

Chronic administration of dietary L-Arginine reverses opioid hyposensitivity for the relief of tactile allodynia in a rat model of diabetic neuropathy

Lotfipour, S., Ross, F. B., Brown, L. C. and Smith, M. T. (2005). Chronic administration of dietary L-Arginine reverses opioid hyposensitivity for the relief of tactile allodynia in a rat model of diabetic neuropathy. 11th World Congress on Pain, Sydney, 21-26 August 2005. USA: IASP Press.

In vivo proof-of-concept study: Commercialisation and regulatory imperatives

Smith, M. T. (2005). In vivo proof-of-concept study: Commercialisation and regulatory imperatives. Joint Meeting of ASCEPT and APSA, Melbourne, 4-7 December 2005. Australia: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists.

Insulin implants prevent the temporal development of tactile allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic Wistar rats

Otto, K. J., Wyse, B. D., Cabot, P. J. and Smith, M. T. (2005). Insulin implants prevent the temporal development of tactile allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic Wistar rats. 11th World Congress on Pain, Sydney, 21-26 Aug. 2005. USA: IASP Press.

Intrathecal XEN2174 produces significant anti-allodynia in morphine-tolerant rats using the CCI-model of persistent neuropathic pain

Smith, M. T., Nielsen, C. K., Hwang, J. C., Kydd, S., Wyse, B. D., Lewis, R. J. and Drinkwater, R. D. (2005). Intrathecal XEN2174 produces significant anti-allodynia in morphine-tolerant rats using the CCI-model of persistent neuropathic pain. 11th World Congress on Pain, Sydney, Australia, 21-26 August 2005. Seattle, Wa.: IASP Press.

Investigation of temporal changes in the anti-allodynic effectiveness of chronically administered gabapentin in a rat model of neuropathic pain

Tan, S., Wyse, B. D., Duffull, S. B. and Smith, M. T. (2005). Investigation of temporal changes in the anti-allodynic effectiveness of chronically administered gabapentin in a rat model of neuropathic pain. 11th World Congress on Pain, Sydney, 21-26 August 2005. USA: IASP Press.

Investigation of the anti-allodynic and anti-hyperalgesics effects of ACV1 in a rat model of neuropathic pain

Wyse, B. D., Hwang, J. C., Kydd, S., Patterson, M., Nielsen, C. K., Belyea, C., McIntosh, D. and Smith, M. T. (2005). Investigation of the anti-allodynic and anti-hyperalgesics effects of ACV1 in a rat model of neuropathic pain. 11th World Congress on Pain, Sydney, Australia, 21-26 August 2005. Seattle, Wa.: IASP Press.

Pain and its treatment

Smith, M. T. (2005). Pain and its treatment. 6th Australian Peptide Conference, Hamilton Island, Australia, 9-15 October, 2005.

What you and your patient need to know about opioids

Smith, M. T., Moore, B. and Molloy, A. (2005). What you and your patient need to know about opioids. Partners in Pain: Patients, Clinicians and Pain Management, Sydney, Australia, 18-19 August, 2005.

Anti-allodynic effects of Xen2174 in rats with neuropathy. Abstract

Smith, M. T., Nielsen, C., Lewis, R., Alewood, D. and Drinkwater, R. D. (2004). Anti-allodynic effects of Xen2174 in rats with neuropathy. Abstract. ANZCA Annual Scientific Meeting, Perth, Western Australia, 1-5 May, 2004. Australia: ANZCA.

Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain

Nielsen, C., Smith, M. T., Lewis, R., Alewood, D. and Drinkwater, R. D. (2004). Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. CPT2004: 8th World Congress on Clinical Pharmacology & Therapeutics, Brisbane, Qld, Australia, 1-6 August, 2004. Oxford, United Kingdom: Blackwell Scientific Publications. doi: 10.1111/j.1440-1681.2004.cep_4027.pdf.x

Assessment of working spatial memory utilising T-maze and Morris water-maze for the study of a rodent model of alzheimer's disease

Patel, A., Smith, M. T. and Cabot, P. J. (2004). Assessment of working spatial memory utilising T-maze and Morris water-maze for the study of a rodent model of alzheimer's disease. 4th Annual Queensland Health and Medical Scientific Meeting, Brisbane, 30 November - 1 December 2004. Brisbane: Qld Government.

Comparative pharmacokinetics and metabolism of subcutaneous oxycodone in male dark agouti relative to sprague-dawley rats

Huang, L., Edwards, S. R. and Smith, M. T. (2004). Comparative pharmacokinetics and metabolism of subcutaneous oxycodone in male dark agouti relative to sprague-dawley rats. CTP 2004, Brisbane, 1-6 August 2004. Australia: Blackwell Publishing Asia.

Determination of morphine, oxycodone, morphine-3-glucuronide, & noroxycodone concentrations in rat serum by liquid chromatography (LC) - electrospray mass spectrometry (EMS)

Edwards, S. R. and Smith, M. T. (2004). Determination of morphine, oxycodone, morphine-3-glucuronide, & noroxycodone concentrations in rat serum by liquid chromatography (LC) - electrospray mass spectrometry (EMS). CPT2004, Brisbane, 1-6 August 2004. Australia: Blackwell Publishing.

Effect of insulin treatment on diabetic characteristics in the STZ-diabetic rat

Otto, K. J., Wyse, B. D., Cabot, P. J. and Smith, M. T. (2004). Effect of insulin treatment on diabetic characteristics in the STZ-diabetic rat. 4th Annual Queensland Health and Medical Scientific Meeting, Brisbane, 30 Nov - 1 Dec 2004. Brisbane: Qld Government.

Longitudinal investigation of the antinociceptive potency of oxycodone and morphine in the zucker rat

Tsui, D. Y., Hawes, S., Patterson, M. and Smith, M. T. (2004). Longitudinal investigation of the antinociceptive potency of oxycodone and morphine in the zucker rat. Clinical Pharmacology and Therapeutics 2004, Brisbane, 1-6 August, 2004. Australia: Blackwell Publishing.

Opioid rotation and methadone: Pharmacokinetic considerations

Smith, M. T., Fleming, J. A. and Connor, M. (2004). Opioid rotation and methadone: Pharmacokinetic considerations. 2004 ANZCA Annual Scientific Meeting, Perth, Western Australia, 1-5 May, 2004. Melbourne, Vic, Australia: Australian and New Zealand College of Anaesthetists (ANZCA).

Opioids and NMDA receptors: Neuro-excitation and abnormal pain behaviours

Smith, M. T. (2004). Opioids and NMDA receptors: Neuro-excitation and abnormal pain behaviours. ANZCA Annual Scientific Meeting, Perth, 1-5 May 2004. Australia: ANZCA.

Oxycodone: A dose ranging pharmacodynamic study in dogs

Bubb, L. M., Keates, H. L. and Smith, M. T. (2004). Oxycodone: A dose ranging pharmacodynamic study in dogs. Proc. of Assoc. of Veterinary Anaesthetists, Vienna, Austria, 16-17 September 2004. Austria:

Oxycodone: A dose ranging pharmacodynamic study in dogs

Bubb, L. M., Keates, H. L. and Smith, M. T. (2004). Oxycodone: A dose ranging pharmacodynamic study in dogs. Showcasing Faculty research through our postgraduates, Gatton, 5th November 2004. Gatton: NRAVS Faculty.

P2.3 longitudinal investigation of the comparative anti-allodynic potencies of oxycodone and morphine in the zucker rat relative to the streptozotocin-induced diabetic rat

Tsui, D.Y., Hawes, S., Patterson, M. and Smith, M. T. (2004). P2.3 longitudinal investigation of the comparative anti-allodynic potencies of oxycodone and morphine in the zucker rat relative to the streptozotocin-induced diabetic rat. 25th Annual Scientific Meeting of the Australian Pain Society, Canberra, 7-10 March 2004. Australia: Australian Pain Society.

The pro-allodynic effects of morphine-3-glucuronide (M3G) appear to be opioid-receptor mediated

Nielsen, C., De Cruz, S. E. and Smith, M. T. (2004). The pro-allodynic effects of morphine-3-glucuronide (M3G) appear to be opioid-receptor mediated. 25th Annual Scientific Meeting of the Australian Pain Society, Canberra, 7-10 March 2004. Australia: Australian Pain Society.

The pro-allodynic effects of morphine-3-glucuronide (M3G) in the rat

Smith, M. T., Le, L., Hemstapat, K., De Cruz, S. E. and Nielsen, C. (2004). The pro-allodynic effects of morphine-3-glucuronide (M3G) in the rat. CTP 2004, Brisbane, 1-6 Aug 2004. Australia: Blackwell Publishing Asia.

A fresh approach to neuropathic pain management: From the animal model to the patient

Moore, B., Azzopardi, J., Cabot, P. J., Gray, P., Roufogalis, B. and Smith, M. T. (2003). A fresh approach to neuropathic pain management: From the animal model to the patient. Combined meeting of the Australian Pain Society 24th ASM and New Zealand Pain Society 10th ASM, Christchurch, NZ, 9-13 March 2003. Sydney: Australian Pain Society.

Longitudinal investigation of the antinociceptive potency of oxycodone and morphine in the Zucker rat

Tsui, D. Y., Hawes, S., Patterson, M. and Smith, M. T. (2003). Longitudinal investigation of the antinociceptive potency of oxycodone and morphine in the Zucker rat. Annual Scientific Meeting of Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists 2003, Sydney, 30 November - 3 December 2003. Melbourne: ASCEPT.

Quantification of morphine, oxycodone, morphine-3-glucuronide and noroxycodone in rat serum by high performance liquid chromatography (HPLC-electrospray mass spectrometry (EMS)

Edwards, S. R. and Smith, M. T. (2003). Quantification of morphine, oxycodone, morphine-3-glucuronide and noroxycodone in rat serum by high performance liquid chromatography (HPLC-electrospray mass spectrometry (EMS). Annual Scientific Meeting of ASCEPT 2003, Sydney, 30 November - 3 December 2003. Melbourne: ASCEPT.

Serum concentrations of metabolically-derived oxymorphone are insignificant in diabetic and non-diabetic adult male Dark Agouti rats following subcutaneous oxycodone bolus administration: Comparison with Sprague-Dawley rats

Huang, L., Le, L., Edwards, S. R. and Smith, M. T. (2003). Serum concentrations of metabolically-derived oxymorphone are insignificant in diabetic and non-diabetic adult male Dark Agouti rats following subcutaneous oxycodone bolus administration: Comparison with Sprague-Dawley rats. Annual Scientific Meeting of ASCEPT, Sydney, 30 November - 3 December 2003. Melbourne: ASCEPT.

Anti-allodynic efficacy of the conopeptide, MR1A, in rats with neuropathic pain

Nielsen, C., Ross, F. B., Lewis, R. J., Drinkwater, R. D. and Smith, M. T. (2002). Anti-allodynic efficacy of the conopeptide, MR1A, in rats with neuropathic pain. 10th World Congress on Pain, San Diego, 17-22 Aug. 2002. Seattle: IASP Press.

Anti-allodynic efficacy of the x-conipeptide, MR1A, in rats with neuropathic pain

Nielsen, C., Ross, F. B., Lewis, R. J., Drinkwater, R. D. and Smith, M. T. (2002). Anti-allodynic efficacy of the x-conipeptide, MR1A, in rats with neuropathic pain. AHMR Congress 2002, Melbourne, 24-29 Nov. 2002. Melbourne: NHMRC.

Electrolyte removal from artificial CSF by HPLC to restore ESI-MS/MS signal intensity in quantification of morphine and its glucuronide metabolites

Wells, J. A., Punjanon, T. and Smith, M. T. (2002). Electrolyte removal from artificial CSF by HPLC to restore ESI-MS/MS signal intensity in quantification of morphine and its glucuronide metabolites. 10th World Congress on Pain, San Diego, 17-22 Aug. 2002. Seattle: IASP Press.

In vivo investigation of the effects of intracerebroventricular (ICV) morphine-3-glucuronide (M3G) on von frey paw withdrawal thresholds in rats

Le, L., Hemstapat, K. and Smith, M. T. (2002). In vivo investigation of the effects of intracerebroventricular (ICV) morphine-3-glucuronide (M3G) on von frey paw withdrawal thresholds in rats. AHMR Congress 2002, Melbourne, 24-29 Nov. 2002. Melbourne: NHMRC.

Investigation of the role of dynorphin-A in mediating morphine-3-glucuronide's neuro-excitatory effects

Hemstapat, K., Monteith, G. R. and Smith, M. T. (2002). Investigation of the role of dynorphin-A in mediating morphine-3-glucuronide's neuro-excitatory effects. 10th World Congress on Pain, San Diego, 17-22 Aug. 2002. Seattle: IASP Press.

Oxycodone, but not morphine, is efficacious for the relief of tactile allodynia in diabetic rats at three and six months after the induction of diabetes with streptozotocin

Lotfipour, S., Ross, F. B., Saini, K. and Smith, M. T. (2002). Oxycodone, but not morphine, is efficacious for the relief of tactile allodynia in diabetic rats at three and six months after the induction of diabetes with streptozotocin. 10th World Congress on Pain, San Diego, 17-22 Aug. 2002. Seattle: IASP Press.

P/Q and L-type calcium channel blockers abolish morphine-3-glucuronide (M3G)-induced indirect activation of the NMDA receptor

Hemstapat, K., Monteith, G. R. and Smith, M. T. (2002). P/Q and L-type calcium channel blockers abolish morphine-3-glucuronide (M3G)-induced indirect activation of the NMDA receptor. AHMR Congress 2002, Melbourne, 24-29 Nov. 2002. Melbourne: NHMRC.

Prolonged oestradiol supplementation does not significantly alter levels of antinociception evoked by ICV morphine in adult male rats

Mather, L. E., Punjanon, T. and Smith, M. T. (2002). Prolonged oestradiol supplementation does not significantly alter levels of antinociception evoked by ICV morphine in adult male rats. 10th World Congress on Pain, San Diego, 17-22 Aug. 2002. Seattle: IASP Press.

Serum 17 -oestradiol concentrations are directly correlated with the time to reach peak antinociception in oestradiol-pretreated rats administered prolonged intravenous morphine infusions

Le, L., Chmura, P., Mather, L. E. and Smith, M. T. (2002). Serum 17 -oestradiol concentrations are directly correlated with the time to reach peak antinociception in oestradiol-pretreated rats administered prolonged intravenous morphine infusions. 10th World Congress on Pain, San Diego, 17-22 Aug. 2002. Seattle: IASP Press.

Supraspinally administered oxycodone has intrinsic anti-allodynic effects for the alleviation of tactile allodynia in adult male rats with streptozotocin-induced diabetes

Smith, M. T., Patterson, M. and Ross, F. B. (2002). Supraspinally administered oxycodone has intrinsic anti-allodynic effects for the alleviation of tactile allodynia in adult male rats with streptozotocin-induced diabetes. 10th World Congress on Pain, San Diego, 17-22 August 2002. Seattle: IASP Press.

Differential changes in the potency of supraspinally administered oxycodone relative to morphine for the alleviation of tactile allodynia in adult male Dark Agouti rats with streptozotocin-induced diabetes

Patterson, M., Ross, F. B. and Smith, M. T. (2001). Differential changes in the potency of supraspinally administered oxycodone relative to morphine for the alleviation of tactile allodynia in adult male Dark Agouti rats with streptozotocin-induced diabetes. ASCEPT Annual Scientific Meeting, Dunedin, New Zealand, 3 - 5 December, 2001. Melbourne, Vic: ASCEPT Press.

Electrolyte removal is essential for optimizing ESI-MS/MS signal intensity for the quantification of morphine and morphine-3-glucuronide in samples of rat brain microdialysate

Wells, J. A., Punjanon, T., Wright, A. W. and Smith, M. T. (2001). Electrolyte removal is essential for optimizing ESI-MS/MS signal intensity for the quantification of morphine and morphine-3-glucuronide in samples of rat brain microdialysate. Annual Scientific Meeting of ASCEPT 2001, Dunedin, New Zealand, 3 - 5 December, 2001. Melbourne, Vic: ASCEPT Press.

Evaluation of the neurotoxic effects of morphine-3-glucuronide (M3G) in neuronal cultures.

Hemstapat, K., Smith, S. A., Monteith, G. R. and Smith, M. T. (2001). Evaluation of the neurotoxic effects of morphine-3-glucuronide (M3G) in neuronal cultures.. Annual Conference of APSA, Melbourne, 24-27 Nov 2001. Melbourne: APSA.

Follow-up audit of analgesic prescribing and use at the Multidisciplinary Pain Centre at Royal Brisbane Hospital: Temporal changes in anticonvulsant prescribing from 1999 to 2000

Nissen, L., Mattiazzi, A., Smith, M. T., Moore, B., Williams, B. and Cramond, T. R. (2001). Follow-up audit of analgesic prescribing and use at the Multidisciplinary Pain Centre at Royal Brisbane Hospital: Temporal changes in anticonvulsant prescribing from 1999 to 2000. 22nd Annual Scientific Meeting of Australian Pain Society 2001, Cairns, Qld, 8 - 12 April, 2001. Melbourne: Australian Pain Society.

Heterodimeric opioid receptors: Implications for practice?

Smith, M. T. (2001). Heterodimeric opioid receptors: Implications for practice?. From Science to Practice, 22nd Annual Scientific Meeting of Australian Pain Society, Cairns, Qld, 8-12 Apr 2001. Australian Pain Society.

Heterodimeric opioid receptors: Novel targets for a new generation of opioid analgesics.

Smith, M. T. (2001). Heterodimeric opioid receptors: Novel targets for a new generation of opioid analgesics.. IUPS Satellite Symposium on Pain Mechanisms, The Australian Museum, Sydney, 19-22 Aug 2001. Sydney, Aust.: International Union of Physiological Sciences.

Increased potency of single doses of subcutaneous oxycodone, but not morphine, in Dark Agouti rats with a chronic constriction injury (CCI) of the sciatic nerve relative to control rats.

Ross, F. B., Saini, K. and Smith, M. T. (2001). Increased potency of single doses of subcutaneous oxycodone, but not morphine, in Dark Agouti rats with a chronic constriction injury (CCI) of the sciatic nerve relative to control rats.. 22nd Annual Scientific Meeting of Australian Pain Society, Cairns, Qld, 8-12 April 2001. Melbourne: Australian Pain Society.

Influence of oestradiol pretreatment of adult male rats on levels of antinociception evoked by chronically infused intravenous morphine

Le, L., Chmura, P., Mather, L. E. and Smith, M. T. (2001). Influence of oestradiol pretreatment of adult male rats on levels of antinociception evoked by chronically infused intravenous morphine. Annual Scientific Meeting of ASCEPT, Dunedin, New Zealand, 3 - 5 December, 2001. Melbourne, Vic: ASCEPT Press.

M3G's neuro-excitatory side-effects are mediated pre-synaptically: Mechanistic studies implicating dynorphin A.

Hemstapat, K., Monteith, G. R. and Smith, M. T. (2001). M3G's neuro-excitatory side-effects are mediated pre-synaptically: Mechanistic studies implicating dynorphin A.. Annual Scientific Meeting of ASCEPT 2001, Dunedin, New Zealand, 3 - 5 December, 2001. Melbourne, Vic: ASCEPT Press.

Oxycodone has a distinctly different pharmacology from morphine

Smith, Maree T., Ross, Fraser B., Nielsen, Carsten K. and Saini, Kamal (2001). Oxycodone has a distinctly different pharmacology from morphine. 2nd Asian-Pacific Symposium on Pain Control, Sydney, Australia, 26-28 January, 2001. London, UK: W.B. Saunders. doi: 10.1053/eujp.2001.0301

Pharmacological studies to define the mechanism mediating the neuro-excitatory side-effects of morphine-3-glucuronide (M3G).

Hemstapat, K., Monteith, G. R. and Smith, M. T. (2001). Pharmacological studies to define the mechanism mediating the neuro-excitatory side-effects of morphine-3-glucuronide (M3G).. Australian Society for Medical Research 40th National Scientific Conference, 2001, Surfers Paradise, 24-27 Nov. 2001. Sydney, Aust.: Australian Society for Medical Research.

Preliminery investigation of the ability of oxycodone to stimulate agonist-induced internalisation of the m-opioid receptor

Nielsen, C., Smith, M. T. and Ross, F. B. (2001). Preliminery investigation of the ability of oxycodone to stimulate agonist-induced internalisation of the m-opioid receptor. Annual Scientific Meeting of ASCEPT, Dunedin, New Zealand, 3 - 5 December, 2001. Melbourne, Vic: ASCEPT Press.

Prolonged oestradiol supplementation does not significantly alter levels of antinociception evoked by icv morphine in adult male rats

Punjanon, T., Mather, L. E. and Smith, M. T. (2001). Prolonged oestradiol supplementation does not significantly alter levels of antinociception evoked by icv morphine in adult male rats. Annual Scientific Meeting of ASCEPT, Dunedin, New Zealand, 3 - 5 December, 2001. Melbourne, Vic: ASCEPT Press.

Temporal changes in the potency of subcutaneous oxycodone relative to morphine for the alleviation of tactile allodynia in Dark Agouti Rats with diabetes secondary to streptozotocin injection

Smith, M. T., Ross, F. B., Lotfipour, S. and Saini, K. (2001). Temporal changes in the potency of subcutaneous oxycodone relative to morphine for the alleviation of tactile allodynia in Dark Agouti Rats with diabetes secondary to streptozotocin injection. Annual Scientific Meeting of ASCEPT, Dunedin, New Zealand, 3 - 5 December, 2001. Melbourne, Vic: ASCEPT Press.

The neuro-excitatory effects of morphine-3-glucuronide (M3G): Studies of the possible role of non-NMDA mechanisms in cultured embryonic rat hippocampal neurones.

Hemstapat, K., Smith, D., Monteith, G. R. and Smith, M. T. (2001). The neuro-excitatory effects of morphine-3-glucuronide (M3G): Studies of the possible role of non-NMDA mechanisms in cultured embryonic rat hippocampal neurones.. 22nd Annual Scientific Meeting of Australian Pain Society, Cairns, Qld, 8-12 April 2001. Melbourne: Australian Pain Society.

Absence of antinociceptive cross-tolerance between supraspinal oxycodone and intravenous morphine in the dark agouti rat

Nielsen, C., Ross, F. B. and Smith, M. T. (2000). Absence of antinociceptive cross-tolerance between supraspinal oxycodone and intravenous morphine in the dark agouti rat. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, Newcastle, Australia, 3-6 December, 2000. Melbourne, Vic.: Blackwell Scientific Publications.

Antinociceptive efficacy of intrathecal AM336 for the relief of adjuvant-induced chronic inflammatory pain in the rat hindpaw

Smith, M. T., Ross, F. B., Lewis, R., Kurek, J. and Cabot, P. J. (2000). Antinociceptive efficacy of intrathecal AM336 for the relief of adjuvant-induced chronic inflammatory pain in the rat hindpaw. Joint Meeting of ASCEPT and the British Pharmacological Society, Melbourne, Australia, 26 - 28 April, 2000. Melbourne, Vic.: Blackwell Scientific Publications.

Determination of morphine, M3G, M6G, oxycodone and their N-demethylated metabolites in biological fluids, using HPLC-MS/MS

Wright, A. W., Punjanon, T. and Smith, M. T. (2000). Determination of morphine, M3G, M6G, oxycodone and their N-demethylated metabolites in biological fluids, using HPLC-MS/MS. he Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, Newcastle, Australia, 3 - 6 December, 2000. Melbourne, Vic.: Blackwell Scientific Publications.

Differential potency of subcutaneous morphine and oxycodone for the relief of mechanical allodynia in dark agouti rats with a chronic constriction injury (CCI) of the sciatic nerve

Ross, F. B., Saini, K. and Smith, M. T. (2000). Differential potency of subcutaneous morphine and oxycodone for the relief of mechanical allodynia in dark agouti rats with a chronic constriction injury (CCI) of the sciatic nerve. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, Newcastle, Australia, 3 - 6 December, 2000. Melbourne, Vic.: Blackwell Scientific Publications.

Elucidation of the mechanism underlying the neuro-excitatory effects of morphine-3-glucoronide (M3G): Studies in rat embryonic hippocampal neurones

Hemstapat, K., Smith, D., Monteith, G. R. and Smith, M. T. (2000). Elucidation of the mechanism underlying the neuro-excitatory effects of morphine-3-glucoronide (M3G): Studies in rat embryonic hippocampal neurones. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, Newcastle, Australia, 3-6 December, 2000. Melbourne, Vic.: Blackwell Scientific Publications.

ICV hydromorphone-3-glucuronide (H3G) elicits neuro-excitation in the rat

Wright, A. W., Mather, L. E. and Smith, M. T. (2000). ICV hydromorphone-3-glucuronide (H3G) elicits neuro-excitation in the rat. Joint Meeting of ASCEPT and the British Pharmacological Society, Melbourne, Australia, 26 - 28 April, 2000. Melbourne, Vic.: Blackwell Scientific Publications.

Incomplete and assymetric antinociceptive cross-tolerance between oxycodone and morphine in the rat

Nielsen, C., Ross, F. B. and Smith, M. T. (2000). Incomplete and assymetric antinociceptive cross-tolerance between oxycodone and morphine in the rat. Joint Meeting of ASCEPT and the British Pharmacological Society, Melbourne, Australia, 26 - 28 April, 2000. Melbourne, Vic.: Blackwell Scientific Publications.

Lack of cross-tolerance between intrathecal AM336 and intravenous morphine in contrast to the marked cross-tolerance between ziconotide and morphine

Smith, M. T., Ross, F. B., Lewis, R., Kurek, J. and Cabot, P. J. (2000). Lack of cross-tolerance between intrathecal AM336 and intravenous morphine in contrast to the marked cross-tolerance between ziconotide and morphine. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, Newcastle, Australia, 3 - 6 December, 2000. Melbourne, Vic.: Blackwell Scientific Publications.

Morphine-3-glucuronide (M3G) evoked increases in [Ca2+]cyt oscillations in cultured rat embryonic hippocampal neurones

Hemstapat, K., Monteith, G. R. and Smith, M. T. (2000). Morphine-3-glucuronide (M3G) evoked increases in [Ca2+]cyt oscillations in cultured rat embryonic hippocampal neurones. Australasian Pharmaceutical Science Association 2000 Annual Conference, Newcastle, Australia, 6 - 8 December, 2000. University of Qld: Australasian Pharmaceutical Science Association.

Spontaneous oscillations in neuronal cytosolic free Ca2+ ([Ca2+]cyt ) in rat cultured embryonic hippocampal neurons maintained in serum-free neurobasal medium

Hemstapat, K., Monteith, G. R. and Smith, M. T. (2000). Spontaneous oscillations in neuronal cytosolic free Ca2+ ([Ca2+]cyt ) in rat cultured embryonic hippocampal neurons maintained in serum-free neurobasal medium. Joint Meeting of ASCEPT and the British Pharmacological Society, Melbourne, Australia, 26 - 28 April, 2000. Melbourne, Vic.: Blackwell Scientific Publications.

Antinociceptive potencies and motor effects of the calcium channel blockers, AM336 and ziconotide, following intrathecal administration to FCA-treated rats

Ross, F. B., Cabot, P. J., Robertson, A. D. and Smith, M. T. (1999). Antinociceptive potencies and motor effects of the calcium channel blockers, AM336 and ziconotide, following intrathecal administration to FCA-treated rats. 9th World Congress on Pain, Vienna, Austria, 22 - 27 August, 1999. Seattle, USA: IASP Press.

Effect of testosterone on the antinociceptive effects of iv and icv morphine in adult female Sprague-Dawley rats

Smith, M. T. and South, S. M. (1999). Effect of testosterone on the antinociceptive effects of iv and icv morphine in adult female Sprague-Dawley rats. 33rd Annual Scientific Meeting of ASCEPT, Darling Harbour, Sydney, 4 - 8 December, 1999. Melbourne, Vic: ASCEPT.

Hydromorphone-3-glucuronide (H3G) is a more potent neuro-excitant than morphine-3-glucuronide (M3G) in the rat

Wright, A.W. and Smith, M. T. (1999). Hydromorphone-3-glucuronide (H3G) is a more potent neuro-excitant than morphine-3-glucuronide (M3G) in the rat. 9th World Congress on Pain, Vienna, Austria, 22 - 27 August, 1999. Seattle, USA: IASP Press.

Incomplete antinociceptive cross-tolerance between oxycodone and morphine in the rat

Nielsen, C., Ross, F. B. and Smith, M. T. (1999). Incomplete antinociceptive cross-tolerance between oxycodone and morphine in the rat. 9th World Congress on Pain, Vienna, Austria, 22 - 27 August, 1999. Seattle, USA: IASP Press.

Inhibition of K+-evoked substance P release from slices of rat spinal cord by the novel calcium channel blockers, AM336 and AM543, relative to ziconotide

Cabot, P. J., Ross, F. B., Robertson, A. D. and Smith, M. T. (1999). Inhibition of K+-evoked substance P release from slices of rat spinal cord by the novel calcium channel blockers, AM336 and AM543, relative to ziconotide. 9th World Congress on Pain, Vienna, Austria, 22 - 27 August, 1999. Seatle, USA: IASP Press.

Opioid analgesic prescribing and use - An audit of analgesic prescribing by general practitioners and the Multidisciplinary Pain Centre at Royal Brisbane Hospital

Nissen, L. M., Smith, M. T., Tett, S. E., Williams, B. and Cramond, T. R. (1999). Opioid analgesic prescribing and use - An audit of analgesic prescribing by general practitioners and the Multidisciplinary Pain Centre at Royal Brisbane Hospital. Annual Scientific Meeting of the Australian Pain Society, Freemantle, W.A., 21-25 April 1999. Perth, Western Australia: Australian Pain Society.

Opioid analgesic prescribing and use: An audit of analgesic prescribing by general practitioners and the Multidisciplinary Pain Centre at Royal Brisbane Hospital

Nissen, L. M., Smith, M. T., Tett, S. E., Williams, B. and Cramond, T. R. (1999). Opioid analgesic prescribing and use: An audit of analgesic prescribing by general practitioners and the Multidisciplinary Pain Centre at Royal Brisbane Hospital. Society of Hospital Pharmacists of Australia 24th Federal Conference, Perth, W.A., 25 - 28 November, 1999. Melbourne, Australia: Society of Hospital Pharmacists of Australia.

Opioid analgesic prescribing and use: an audit of analgesic prescribing by general practitioners and the multidisciplinary Pain Centre at Royal Brisbane Hospital

Nissen, L. M., Smith, M. T., Tett, S. E., Williams, B. and Cramond, T. R. (1999). Opioid analgesic prescribing and use: an audit of analgesic prescribing by general practitioners and the multidisciplinary Pain Centre at Royal Brisbane Hospital. Rationale, Resistance and Research. Royal Brisbane Hospital Health Care Symposium, Royal Brisbane Hospital, Brisbane, 21 - 27 October, 1999. Brisbane, Australia: Royal Brisbane Hospital Res. Foundation.

Systematic investigation of sex differences in the antinociceptive effects of morphine in the rat

South, S. M. and Smith, M. T. (1999). Systematic investigation of sex differences in the antinociceptive effects of morphine in the rat. 9th World Congress on Pain, Vienna, Austria, 22 - 27 August, 1999. Seattle, USA: IASP Press.

Tissue temperature as a function of heat exposure time using the tail flick latency test for both the dorsal and ventral surfaces of the rat tail

Smith, M. T. and Hemstapat, K. (1999). Tissue temperature as a function of heat exposure time using the tail flick latency test for both the dorsal and ventral surfaces of the rat tail. 9th World Congress on Pain, Vienna, Austria, 22 - 27 August, 1999. Seattle, USA: IASP Press.

Nonconventional Opioid Receptors in Human and Rat Lung

Cabot, PJ, Smith, MT, Cramond, TR and Dodd, PR (1992). Nonconventional Opioid Receptors in Human and Rat Lung. PHILADELPHIA: LIPPINCOTT-RAVEN PUBL.

SERIAL CAFFEINE AND ANTIPYRINE CLEARANCES IN THE ASSESSMENT OF DISEASE PROGRESSION WITH PARTICULAR REFERENCE TO LIVER-TRANSPLANTATION

CHENG, SCW, MURPHY, TL, SMITH, MT, COOKSLEY, WGE, HALLIDAY, JW and POWELL, LW (1988). SERIAL CAFFEINE AND ANTIPYRINE CLEARANCES IN THE ASSESSMENT OF DISEASE PROGRESSION WITH PARTICULAR REFERENCE TO LIVER-TRANSPLANTATION. PHILADELPHIA: W B SAUNDERS CO.

DOSE-DEPENDENT PHARMACOKINETICS OF CAFFEINE - RELEVANCE TO THE QUANTITATIVE ASSESSMENT OF LIVER-FUNCTION

CHENG, SCW, MURPHY, TL, SMITH, MT, HALLIDAY, JW and POWELL, LW (1988). DOSE-DEPENDENT PHARMACOKINETICS OF CAFFEINE - RELEVANCE TO THE QUANTITATIVE ASSESSMENT OF LIVER-FUNCTION. BALGOWLAH: ADIS PRESS AUSTRALASIA P/L.

PROPRANOLOL IN PREGNANCY, A 3 YEAR PROSPECTIVE-STUDY

LIVINGSTONE, , SMITH, MT, CRASWELL, PW, BEVAN, EB and EADIE, MJ (1982). PROPRANOLOL IN PREGNANCY, A 3 YEAR PROSPECTIVE-STUDY. NEW YORK: MARCEL DEKKER INC.

Pain-relieving compositions and uses therefore

Smith, M. T. (2008). Pain-relieving compositions and uses therefore. PCT/AU2008/000003: WO/2008/080194.

Method of treatment or prophylaxis

Smith, Maree and Wyse, Bruce (2007). Method of treatment or prophylaxis. WO/2006/066361.

Methods of treating pain

Smith, Maree and Williams, Craig (2006). Methods of treating pain. PCT/AU2005/001976.

Method of treatment or prophylaxis

Smith, Maree Therese and Wyse, Bruce Douglas (2006). Method of treatment or prophylaxis. 2004907332.

Compositions comprising nitric oxide donors and opioid analgesics

Smith, M. T., Brown, L. C., Harvey, M. and Williams, C. M. (2003). Compositions comprising nitric oxide donors and opioid analgesics. PCT/AU03/00335.

Methods of treatment and/or prophylaxis

Smith, M. T. and Brown, L. (2003). Methods of treatment and/or prophylaxis. PCT/AU03/00336.