The University of Queensland

Biofilm Persisters Formation, Molecular Mechanisms and Strategies for Tackling

Li, Peng, Seneviratne, Chaminda Jayampath and Jin, Lijian (2017). Biofilm Persisters Formation, Molecular Mechanisms and Strategies for Tackling. Microbial Biofilms: Omics Biology, Antimicrobials and Clinical Implications. (pp. 193-202) CRC Press. doi: 10.4324/9781315120119-8

Host-Biofilm Interactions at Mucosal Surfaces and Implications in Human Health

Venkiteswaran, Nityasri, Ellepola, Kassapa, Seneviratne, Chaminda Jayampath, Lee, Yuan Kun, Puan, Kia Joo and Wong, Siew Cheng (2017). Host-Biofilm Interactions at Mucosal Surfaces and Implications in Human Health. Microbial Biofilms: Omics Biology, Antimicrobials and Clinical Implications. (pp. 203-235) CRC Press. doi: 10.4324/9781315120119-9

Microbial biofilms:  an introduction to their development, properties and clinical implications

Seneviratne, Chaminda Jayampath, Srivastava, Neha, Islam, Intekhab, Foong, Kelvin and Allen, Finbarr (2017). Microbial biofilms:  an introduction to their development, properties and clinical implications. Microbial biofilms: omics biology, antimicrobials and clinical implications. (pp. 1-31) edited by Chaminda Jayampath Seneviratne. Boca Raton, FL, United States: CRC Press. doi: 10.4324/9781315120119-1

Association of candida with linear gingival erythema in HIV-infected subjects

Seneviratne, Chaminda Jayampath and Jayasinghe, Ruwan Duminda (2015). Association of candida with linear gingival erythema in HIV-infected subjects. Oral Candidosis: Physiopathology, Decision Making, and Therapeutics. (pp. 83-94) Springer Berlin Heidelberg. doi: 10.1007/978-3-662-47194-4_12

An overview of H5N1 infection and its implications for dentistry

Seneviratne, C. J. and Samaranayake, L. P. (2011). An overview of H5N1 infection and its implications for dentistry. Clinical Dentistry. (pp. 9-28) Nova Science Publishers, Inc..

Drug resistance mechanisms of fungal biofilms

Seneviratne, C. Jayampath and Samaranayake, Lakshman P. (2011). Drug resistance mechanisms of fungal biofilms. Biofilms: Formation, Development and Properties. (pp. 373-396) Nova Science Publishers, Inc..

Antibiotic resistance in the microbiota of periodontitis patients: an update of current findings

Ng, Ethan, Tay, John Rong Hao, Boey, Sean Kuan, Laine, Marja L, Ivanovski, Sašo and Seneviratne, Chaminda Jayampath (2023). Antibiotic resistance in the microbiota of periodontitis patients: an update of current findings. Critical Reviews in Microbiology, 1-12. doi: 10.1080/1040841x.2023.2197481

IDF2022-0987 Development of a Clinical Risk Model for Targeted Screening of Undiagnosed Diabetes in Asian Dental Settings

Chee, H.K., Htoon, H.M. and Seneviratne, C.J. (2023). IDF2022-0987 Development of a Clinical Risk Model for Targeted Screening of Undiagnosed Diabetes in Asian Dental Settings. Diabetes Research and Clinical Practice, 197 (Diabetologia 55 2012) 110493, 110493. doi: 10.1016/j.diabres.2023.110493

Amelioration strategies for silver diamine fluoride: moving from black to white

Almuqrin, Amjad, Kaur, Inder Preet, Walsh, Laurence J., Seneviratne, Chaminda Jayampath and Zafar, Sobia (2023). Amelioration strategies for silver diamine fluoride: moving from black to white. Antibiotics, 12 (2) 298, 1-18. doi: 10.3390/antibiotics12020298

Antimicrobial-free graphene nanocoating decreases fungal yeast-to-hyphal switching and maturation of cross-kingdom biofilms containing clinical and antibiotic-resistant bacteria

Agarwalla, Shruti Vidhawan, Ellepola, Kassapa, Sorokin, Vitaly, Ihsan, Mario, Silikas, Nikolaos, Neto, AH Castro, Seneviratne, Chaminda Jayampath and Rosa, Vinicius (2022). Antimicrobial-free graphene nanocoating decreases fungal yeast-to-hyphal switching and maturation of cross-kingdom biofilms containing clinical and antibiotic-resistant bacteria. Biomaterials and Biosystems, 8 100069, 1-7. doi: 10.1016/j.bbiosy.2022.100069

Characterization of oral veillonella species in dental biofilms in healthy and stunted groups of children aged 6–7 years in East Nusa Tenggara

Theodorea, Citra Fragrantia, Diven, Saint, Hendrawan, Devin, Djais, Ariadna Adisattya, Bachtiar, Boy Muchlis, Widyarman, Armelia Sari and Seneviratne, Chaminda Jayampath (2022). Characterization of oral veillonella species in dental biofilms in healthy and stunted groups of children aged 6–7 years in East Nusa Tenggara. International Journal of Environmental Research and Public Health, 19 (21) 13998, 1-9. doi: 10.3390/ijerph192113998

Coronavirus disease 2019 (COVID-19) vaccines: a concise review

Samaranayake, Lakshman Perera, Seneviratne, Chaminda Jayampath and Fakhruddin, Kausar Sadia (2022). Coronavirus disease 2019 (COVID-19) vaccines: a concise review. Oral Diseases, 28 (S2), 2326-2336. doi: 10.1111/odi.13916

BNT162b2 mRNA vaccine–induced immune response in oral fluids and serum

Seneviratne, Chaminda Jayampath, Balan, Preethi, de Alwis, Ruklanthi, Udawatte, Nadeeka S., Herath, Thanuja, Toh, Justin Z. N., Tin, Goh Bee, Ooi, Eng Eong, Hong, Jenny Low Guek and Ying, Jean Sim Xiang (2022). BNT162b2 mRNA vaccine–induced immune response in oral fluids and serum. International Dental Journal, 73 (3), 435-442. doi: 10.1016/j.identj.2022.09.005

Short- term effect of probiotic Lactobacillus reuteri consumption on the salivary microbiome profile of subjects undergoing orthodontic treatment with fixed appliances

Widyarman, Armelia Sari, Udawatte, Nadeeka S., Roeslan, Moehamad Orliando, Rizal, Muhammad Ihsan, Richi, Mario, Kusnoto, Joko and Seneviratne, Chaminda Jayampath (2022). Short- term effect of probiotic Lactobacillus reuteri consumption on the salivary microbiome profile of subjects undergoing orthodontic treatment with fixed appliances. Journal of Oral Microbiology, 14 (1) 2067103, 1-11. doi: 10.1080/20002297.2022.2067103

Letter to the Editor, “Sources of SARS-CoV-2 and Other Microorganisms in Dental Aerosols”

Ng, E., Tay, J. R.H., Leung, N. H.L. and Seneviratne, C. J. (2022). Letter to the Editor, “Sources of SARS-CoV-2 and Other Microorganisms in Dental Aerosols”. Journal of Dental Research, 101 (2), 236-236. doi: 10.1177/00220345211037224

Community dynamics of subgingival microbiome in periodontitis and targets for microbiome modulation therapy

Balan, Preethi, Belibasakis, Georgios, Ivanovski, Saso, Bostanci, Nagihan and Seneviratne, Chaminda Jayampath (2022). Community dynamics of subgingival microbiome in periodontitis and targets for microbiome modulation therapy. Critical Reviews in Microbiology, 1-13. doi: 10.1080/1040841X.2022.2133594

Salivary proteomic profiling identifies role of neutrophil extracellular traps formation in pregnancy gingivitis

Balan, Preethi, Chong, Yap Seng, Lin, Qingsong, Lim, Teck Kwang, Suriyanarayanan, Tanujaa, Udawatte, Nadeeka Shiyamalee, Wong, Mun Loke, Lopez, Violeta, He, Hong-Gu and Seneviratne, Chaminda Jayampath (2022). Salivary proteomic profiling identifies role of neutrophil extracellular traps formation in pregnancy gingivitis. Immunological Investigations, 51 (1), 103-119. doi: 10.1080/08820139.2020.1810704

Author Correction: Heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts (Scientific Reports, (2016), 6, 1, (29829), 10.1038/srep29829)

Herath, Thanuja D. K., Darveau, Richard P., Seneviratne, Chaminda J., Wang, Cun-Yu, Wang, Yu and Jin, Lijian (2021). Author Correction: Heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts (Scientific Reports, (2016), 6, 1, (29829), 10.1038/srep29829). Scientific Reports, 11 (1) 2337. doi: 10.1038/s41598-021-81798-0

Isobaric tags for relative and absolute quantification (iTRAQ)-based quantitative analysis of the salivary proteome during healthy pregnancy and pregnancy gingivitis

Balan, Preethi, Chong, Yap S., Lin, Qingsong, Lim, Teck Kwang, Li, Huihua, Wong, Mun L., Lopez, Violeta, He, Hong Gu and Seneviratne, Chaminda Jayampath (2021). Isobaric tags for relative and absolute quantification (iTRAQ)-based quantitative analysis of the salivary proteome during healthy pregnancy and pregnancy gingivitis. Journal of Clinical Periodontology, 48 (12), 1559-1569. doi: 10.1111/jcpe.13559

Graphene nanocoating: high quality and stability upon several stressors

Rosa, V., Malhotra, R., Agarwalla, S. V., Morin, J. L.P., Luong-Van, E. K., Han, Y. M., Chew, R. J.J., Seneviratne, C. J., Silikas, N., Tan, K. S., Nijhuis, C. A. and Castro Neto, A. H. (2021). Graphene nanocoating: high quality and stability upon several stressors. Journal of Dental Research, 100 (10), 1169-1177. doi: 10.1177/00220345211024526

Effects of Hawley, Essix, and Vivera® retainers on salivary properties, oral hygiene, and streptococcus mutans levels: A prospective clinical pilot study

Da Jason, Chua Sheng, Seneviratne, Chaminda Jayampath, Wong, Hung Chew and Yow, Mimi (2021). Effects of Hawley, Essix, and Vivera® retainers on salivary properties, oral hygiene, and streptococcus mutans levels: A prospective clinical pilot study. APOS Trends in Orthodontics, 11 (3) 198, 198-208. doi: 10.25259/APOS_5_2021

Quantitative proteomics analysis identifies salivary biomarkers for early detection of pregnancy loss in a Singaporean cohort—a pilot study

Balan, Preethi, Chong, Yap Seng, Qingsong, Lin, Lim, Teck Kwang, Wong, Mun Loke, Lopez, Violeta, Hong-Gu, H. E. and Seneviratne, Chaminda Jayampath (2021). Quantitative proteomics analysis identifies salivary biomarkers for early detection of pregnancy loss in a Singaporean cohort—a pilot study. Proteomics - Clinical Applications, 15 (4) 2000068. doi: 10.1002/prca.202000068

Subgingival microbiota during healthy pregnancy and pregnancy gingivitis

Balan, P., Brandt, B. W., Chong, Y. S., Crielaard, W., Wong, M. L., Lopez, V., He, H. G. and Seneviratne, C. J. (2021). Subgingival microbiota during healthy pregnancy and pregnancy gingivitis. JDR Clinical and Translational Research, 6 (3), 343-351. doi: 10.1177/2380084420948779

Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore

Seneviratne, Chaminda J., Balan, Preethi, Ko, Kwan Ki Karrie, Udawatte, Nadeeka S., Lai, Deborah, Ng, Dorothy Hui Lin, Venkatachalam, Indumathi, Lim, Kheng Sit, Ling, Moi Lin, Oon, Lynette, Goh, Bee Tin and Sim, Xiang Ying Jean (2021). Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore. Infection, 49 (2), 305-311. doi: 10.1007/s15010-020-01563-9

Metagenomic sequencing provides new insights into the subgingival bacteriome and aetiopathology of periodontitis

Ng, Ethan, Tay, John R. H., Balan, P., Ong, Marianne M. A., Bostanci, Nagihan, Belibasakis, Georgios N. and Seneviratne, Chaminda J. (2021). Metagenomic sequencing provides new insights into the subgingival bacteriome and aetiopathology of periodontitis. Journal of Periodontal Research, 56 (2), 205-218. doi: 10.1111/jre.12811

Casein phosphopeptide–amorphous calcium phosphate fluoride treatment enriches the symbiotic dental plaque microbiome in children

Widyarman, Armelia Sari, Udawatte, Nadeeka S., Theodorea, Citra Fragrantia, Apriani, Anie, Richi, Mario, Astoeti, Tri Erri and Seneviratne, Chaminda Jayampath (2021). Casein phosphopeptide–amorphous calcium phosphate fluoride treatment enriches the symbiotic dental plaque microbiome in children. Journal of Dentistry, 106 103582, 1-8. doi: 10.1016/j.jdent.2021.103582

Proteomic analysis of Caspofungin-induced responses in planktonic cells and biofilms of Candida albicans

Li, Peng, Seneviratne, Chaminda J., Luan, Qingxian and Jin, Lijian (2021). Proteomic analysis of Caspofungin-induced responses in planktonic cells and biofilms of Candida albicans. Frontiers in Microbiology, 12 639123, 1-11. doi: 10.3389/fmicb.2021.639123

Persistent inhibition of Candida albicans biofilm and hyphae growth on titanium by graphene nanocoating

Agarwalla, Shruti Vidhawan, Ellepola, Kassapa, Silikas, Nikolaos, Castro Neto, A. H., Seneviratne, Chaminda Jayampath and Rosa, Vinicius (2021). Persistent inhibition of Candida albicans biofilm and hyphae growth on titanium by graphene nanocoating. Dental Materials, 37 (2), 370-377. doi: 10.1016/j.dental.2020.11.028

Probiotic therapy for periodontal and peri-implant health – silver bullet or sham?

Ng, E., Tay, J. R. H., Ong, M. M. A., Bostanci, N., Belibasakis, G. N. and Seneviratne, C. J. (2021). Probiotic therapy for periodontal and peri-implant health – silver bullet or sham?. Beneficial Microbes, 12 (3), 215-230. doi: 10.3920/BM2020.0182

Role of the oral microbiome, metabolic pathways, and novel diagnostic tools in intra-oral halitosis: a comprehensive update

Foo, Lean Heong, Balan, Preethi, Pang, Li Mei, Laine, Marja L. and Seneviratne, Chaminda Jayampath (2021). Role of the oral microbiome, metabolic pathways, and novel diagnostic tools in intra-oral halitosis: a comprehensive update. Critical Reviews in Microbiology, 47 (3), 359-375. doi: 10.1080/1040841X.2021.1888867

A risk-based approach to the COVID-19 pandemic: the experience in National Dental Centre Singapore

Tay, John Rong Hao, Ng, Ethan, Ong, Marianne Meng Ann, Sim, Chelsia, Tan, Ken and Seneviratne, Chaminda Jayampath (2020). A risk-based approach to the COVID-19 pandemic: the experience in National Dental Centre Singapore. Frontiers in Medicine, 7 562728, 1-10. doi: 10.3389/fmed.2020.562728

Inhibitory effects of xylitol and sorbitol on Streptococcus mutans and Candida albicans biofilms are repressed by the presence of sucrose

Chan, Ally, Ellepola, Kassapa, Truong, Thuyen, Balan, Preethi, Koo, Hyun and Seneviratne, Chaminda Jayampath (2020). Inhibitory effects of xylitol and sorbitol on Streptococcus mutans and Candida albicans biofilms are repressed by the presence of sucrose. Archives of Oral Biology, 119 104886, 1-12. doi: 10.1016/j.archoralbio.2020.104886

Multi-omics tools for studying microbial biofilms: current perspectives and future directions

Seneviratne, Chaminda J., Suriyanarayanan, Tanujaa, Widyarman, Armelia Sari, Lee, Lye Siang, Lau, Matthew, Ching, Jianhong, Delaney, Christopher and Ramage, Gordon (2020). Multi-omics tools for studying microbial biofilms: current perspectives and future directions. Critical Reviews in Microbiology, 46 (6), 759-778. doi: 10.1080/1040841X.2020.1828817

The role of dentists in COVID-19 is beyond dentistry: voluntary medical engagements and future preparedness

Seneviratne, Chaminda Jayampath, Lau, Matthew Wen Jian and Goh, Bee Tin (2020). The role of dentists in COVID-19 is beyond dentistry: voluntary medical engagements and future preparedness. Frontiers in Medicine, 7 566, 1-7. doi: 10.3389/fmed.2020.00566

The proteome of community living Candida albicans is differentially modulated by the morphologic and structural features of the bacterial cohabitants

Truong, Thuyen, Pang, Li Mei, Rajan, Suhasini, Wong, Sarah Sze Wah, Fung, Yi Man Eva, Samaranayake, Lakshman and Seneviratne, Chaminda Jayampath (2020). The proteome of community living Candida albicans is differentially modulated by the morphologic and structural features of the bacterial cohabitants. Microorganisms, 8 (10) 1541, 1-15. doi: 10.3390/microorganisms8101541

Lactobacillus plantarum 108 inhibits Streptococcus mutans and Candida albicans mixed‐species biofilm formation

Srivastava, Neha, Ellepola, Kassapa, Venkiteswaran, Nityasri, Chai, Louis Yi Ann, Ohshima, Tomoko and Seneviratne, Chaminda Jayampath (2020). Lactobacillus plantarum 108 inhibits Streptococcus mutans and Candida albicans mixed‐species biofilm formation. Antibiotics, 9 (8) 478, 1-20. doi: 10.3390/antibiotics9080478

Oral microbiome-systemic link studies: perspectives on current limitations and future artificial intelligence-based approaches

Seneviratne, Chaminda Jayampath, Balan, Preethi, Suriyanarayanan, Tanujaa, Lakshmanan, Meiyappan, Lee, Dong-Yup, Rho, Mina, Jakubovics, Nicholas, Brandt, Bernd, Crielaard, Wim and Zaura, Egija (2020). Oral microbiome-systemic link studies: perspectives on current limitations and future artificial intelligence-based approaches. Critical Reviews in Microbiology, 46 (3), 288-299. doi: 10.1080/1040841X.2020.1766414

Predictive nephrotoxicity profiling of a novel antifungal small molecule in comparison to amphotericin B and voriconazole

Udawatte, Nadeeka S., Kang, Sung Wook, Wang, Yue, Arumugam, Thiruma V. and Seneviratne, Chaminda J. (2020). Predictive nephrotoxicity profiling of a novel antifungal small molecule in comparison to amphotericin B and voriconazole. Frontiers in Pharmacology, 11 511. doi: 10.3389/fphar.2020.00511

Proteomics analysis of Candida albicans dnm1 haploid mutant unraveled the association between mitochondrial fission and antifungal susceptibility

Truong, Thuyen, Zeng, Guisheng, Lim, Teck Kwang, Cao, Tong, Pang, Li Mei, Lee, Yew Mun, Lin, Qingsong, Wang, Yue and Seneviratne, Chaminda Jayampath (2020). Proteomics analysis of Candida albicans dnm1 haploid mutant unraveled the association between mitochondrial fission and antifungal susceptibility. Proteomics, 20 (1) 1900240, 1-12. doi: 10.1002/pmic.201900240

Machine learning and its potential applications to the genomic study of head and neck cancer—a systematic review

Patil, Shankargouda, Habib Awan, Kamran, Arakeri, Gururaj, Jayampath Seneviratne, Chaminda, Muddur, Nagaraj, Malik, Shuaib, Ferrari, Marco, Rahimi, Siavash and Brennan, Peter A. (2019). Machine learning and its potential applications to the genomic study of head and neck cancer—a systematic review. Journal of Oral Pathology and Medicine, 48 (9), 773-779. doi: 10.1111/jop.12854

Multi-omics analyses reveal synergistic carbohydrate metabolism in Streptococcus mutans-Candida albicans mixed-species biofilms

Ellepola, K., Truong, T., Liu, Y., Lin, Q., Lim, T. K., Lee, Y. M., Cao, T., Koo, H. and Seneviratne, C. J. (2019). Multi-omics analyses reveal synergistic carbohydrate metabolism in Streptococcus mutans-Candida albicans mixed-species biofilms. Infection and Immunity, 87 (10) e00339-19, 1-20. doi: 10.1128/IAI.00339-19

Hydrophobicity of graphene as a driving force for inhibiting biofilm formation of pathogenic bacteria and fungi

Agarwalla, Shruti Vidhawan, Ellepola, Kassapa, Costa, Mariana Caldeira Ferraz da, Fechine, Guilhermino José Macêdo, Morin, Julien Luc Paul, Castro Neto, A. H., Seneviratne, Chaminda Jayampath and Rosa, Vinicius (2019). Hydrophobicity of graphene as a driving force for inhibiting biofilm formation of pathogenic bacteria and fungi. Dental Materials, 35 (3), 403-413. doi: 10.1016/j.dental.2018.09.016

Periodontal commensals and pathogens differentially modulate immuno-inflammatory response in human oral keratinocytes

Li, Hua Jing, Seneviratne, Chaminda Jayampath, Wang, Cun Yu and Jin, Li Jian (2019). Periodontal commensals and pathogens differentially modulate immuno-inflammatory response in human oral keratinocytes. The Chinese Journal of Dental Research, 22 (2), 105-112. doi: 10.3290/j.cjdr.a42514

Keystone species in pregnancy gingivitis: a snapshot of oral microbiome during pregnancy and postpartum period

Balan, Preethi, Chong, Yap Seng, Umashankar, Shivshankar, Swarup, Sanjay, Loke, Wong Mun, Lopez, Violeta, He, Hong Gu and Seneviratne, Chaminda Jayampath (2018). Keystone species in pregnancy gingivitis: a snapshot of oral microbiome during pregnancy and postpartum period. Frontiers in Microbiology, 9 (OCT) 2360, 1-11. doi: 10.3389/fmicb.2018.02360

Controlled cellular redox, repressive hemin utilization and adaptive stress responses are crucial to metronidazole tolerance of Porphyromonas gingivalis persisters

Li, Peng, Fung, Yi-Man Eva, Yin, Xiaohui, Seneviratne, Chaminda J., Che, Chi-Ming and Jin, Lijian (2018). Controlled cellular redox, repressive hemin utilization and adaptive stress responses are crucial to metronidazole tolerance of Porphyromonas gingivalis persisters. Journal of Clinical Periodontology, 45 (10), 1211-1221. doi: 10.1111/jcpe.13002

Correction: Quantitative proteomics of strong and weak biofilm formers of Enterococcus faecalis reveals novel regulators of biofilm formation (Molecular and Cellular Proteomics (2018) 17 (643-654) DOI: 10.1074/mcp.RA117.000461)

Suriyanarayanan, Tanujaa, Qingsong, Lin, Kwang, Lim Teck, Mun, Lee Yew, Truong, Thuyen and Seneviratne, Chaminda Jayampath (2018). Correction: Quantitative proteomics of strong and weak biofilm formers of Enterococcus faecalis reveals novel regulators of biofilm formation (Molecular and Cellular Proteomics (2018) 17 (643-654) DOI: 10.1074/mcp.RA117.000461). Molecular and Cellular Proteomics, 17 (10). doi: 10.1074/mcp.AAC118.001077

Oral health in pregnant Chinese women in Singapore: a call to go beyond the traditional clinical care

Balan, Preethi, He, Hong-Gu, Cao, Fengchunzhi, Wong, Mun Loke, Chong, Yap-Seng, Lopez, Violeta, Soh, Shu-E. and Seneviratne, Chaminda Jayampath (2018). Oral health in pregnant Chinese women in Singapore: a call to go beyond the traditional clinical care. Healthcare, 6 (3) 77, 1-12. doi: 10.3390/healthcare6030077

Immunomodulation as therapy for fungal infection: are we closer?

Sam, Qi Hui, Yew, Wen Shan, Seneviratne, Chaminda J., Chang, Matthew Wook and Chai, Louis Yi Ann (2018). Immunomodulation as therapy for fungal infection: are we closer?. Frontiers in Microbiology, 9 (JUL) 1612, 1-16. doi: 10.3389/fmicb.2018.01612

Use of haploid model of Candida albicans to uncover mechanism of action of a novel antifungal agent

Truong, Thuyen, Suriyanarayanan, Tanujaa, Zeng, Guisheng, Le, Thuc D., Liu, Lin, Li, Jiuyong, Tong, Cao, Wang, Yue and Seneviratne, Chaminda J. (2018). Use of haploid model of Candida albicans to uncover mechanism of action of a novel antifungal agent. Frontiers in Cellular and Infection Microbiology, 8 164. doi: 10.3389/fcimb.2018.00164

Is the oral fungal pathogen Candida albicans a cariogen?

Pereira, D. F. A., Seneviratne, C. J., Koga-Ito, C. Y. and Samaranayake, L. P. (2018). Is the oral fungal pathogen Candida albicans a cariogen?. Oral Diseases, 24 (4), 518-526. doi: 10.1111/odi.12691

Quantitative proteomics of strong and weak biofilm formers of Enterococcus faecalis reveals novel regulators of biofilm formation

Suriyanarayanan, Tanujaa, Qingsong, Lin, Kwang, Lim Teck, Mun, Lee Yew and Seneviratne, Chaminda Jayampath (2018). Quantitative proteomics of strong and weak biofilm formers of Enterococcus faecalis reveals novel regulators of biofilm formation. Molecular and Cellular Proteomics, 17 (4), 643-654. doi: 10.1074/mcp.RA117.000461

Graphene onto medical grade titanium: an atom-thick multimodal coating that promotes osteoblast maturation and inhibits biofilm formation from distinct species

Dubey, Nileshkumar, Ellepola, Kassapa, Decroix, Fanny E. D., Morin, Julien L. P., Castro Neto, A. H., Seneviratne, Chaminda J. and Rosa, Vinicius (2018). Graphene onto medical grade titanium: an atom-thick multimodal coating that promotes osteoblast maturation and inhibits biofilm formation from distinct species. Nanotoxicology, 12 (4), 274-289. doi: 10.1080/17435390.2018.1434911

Directed differentiation of human embryonic stem cells to neural crest stem cells, functional peripheral neurons, and corneal keratocytes

Zhu, Qian, Li, Mingming, Yan, Chuan, Lu, Qiqi, Wei, Shunhui, Gao, Rong, Yu, Mengfei, Zou, Yu, Sriram, Gopu, Tong, Huei J., Hunziker, Walter, Seneviratne, Chaminda J., Gong, Zhiyuan, Olsen, Bjorn R. and Cao, Tong (2017). Directed differentiation of human embryonic stem cells to neural crest stem cells, functional peripheral neurons, and corneal keratocytes. Biotechnology Journal, 12 (12) 1700067, 1-11. doi: 10.1002/biot.201700067

Bacterial GtfB augments Candida albicans accumulation in cross-kingdom biofilms

Ellepola, K., Liu, Y., Cao, T., Koo, H. and Seneviratne, C. J. (2017). Bacterial GtfB augments Candida albicans accumulation in cross-kingdom biofilms. Journal of Dental Research, 96 (10), 1129-1135. doi: 10.1177/0022034517714414

Transcriptomics analysis reveals putative genes involved in biofilm formation and biofilm-associated drug resistance of Enterococcus faecalis

Seneviratne, Chaminda J., Suriyanarayanan, Tanujaa, Swarup, Sanjay, Chia, Kuan Hui Burton, Nagarajan, Niranjan and Zhang, Chengfei (2017). Transcriptomics analysis reveals putative genes involved in biofilm formation and biofilm-associated drug resistance of Enterococcus faecalis. Journal of Endodontics, 43 (6), 949-955. doi: 10.1016/j.joen.2017.01.020

Streptococcus mutans forms xylitol-resistant biofilm on excess adhesive flash in novel ex-vivo orthodontic bracket model

Ho, Cindy S.F., Ming, Yue, Foong, Kelvin W.C., Rosa, Vinicius, Thuyen, Truong and Seneviratne, Chaminda J. (2017). Streptococcus mutans forms xylitol-resistant biofilm on excess adhesive flash in novel ex-vivo orthodontic bracket model. American Journal of Orthodontics and Dentofacial Orthopedics, 151 (4), 669-677. doi: 10.1016/j.ajodo.2016.09.017

Comparative ploidy proteomics of Candida albicans biofilms unraveled the role of the AHP1 gene in the biofilm persistence against amphotericin B

Truong, Thuyen, Zeng, Guisheng, Lin, Qingsong, Kwang, Lim Teck, Tong, Cao, Chan, Fong Yee, Wang, Yue and Seneviratne, Chaminda Jayampath (2016). Comparative ploidy proteomics of Candida albicans biofilms unraveled the role of the AHP1 gene in the biofilm persistence against amphotericin B. Molecular and Cellular Proteomics, 15 (11), 3488-3500. doi: 10.1074/mcp.M116.061523

Innate immune response of human embryonic stem cell-derived fibroblasts and mesenchymal stem cells to periodontopathogens

Sriram, Gopu, Natu, Vaishali Prakash, Islam, Intekhab, Fu, Xin, Seneviratne, Chaminda Jayampath, Tan, Kai Soo and Cao, Tong (2016). Innate immune response of human embryonic stem cell-derived fibroblasts and mesenchymal stem cells to periodontopathogens. Stem Cells International, 2016 8905365, 1-15. doi: 10.1155/2016/8905365

Heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts

Herath, Thanuja D. K., Darveau, Richard P., Seneviratne, Chaminda J., Wang, Cun-Yu, Wang, Yu and Jin, Lijian (2016). Heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts. Scientific Reports, 6 29829. doi: 10.1038/srep29829

Synergistic antibacterial effects of nanoparticles encapsulated with Scutellaria baicalensis and pure chlorhexidine on oral bacterial biofilms

Leung, Ken Cham-Fai, Seneviratne, Chaminda Jayampath, Li, Xuan, Leung, Ping Chung, Lau, Clara Bik San, Wong, Chi-Hin, Pang, Ka Yan, Wong, Chun Wai, Wat, Elaine and Jin, Lijian (2016). Synergistic antibacterial effects of nanoparticles encapsulated with Scutellaria baicalensis and pure chlorhexidine on oral bacterial biofilms. Nanomaterials, 6 (4) 61, 1-11. doi: 10.3390/nano6040061

Antifungal susceptibility in serum and virulence determinants of Candida bloodstream isolates from Hong Kong

Seneviratne, Chaminda J., Rajan, Suhasini, Wong, Sarah S. W., Tsang, Dominic N. C., Lai, Christopher K. C., Samaranayake, Lakshman P. and Jin, Lijian (2016). Antifungal susceptibility in serum and virulence determinants of Candida bloodstream isolates from Hong Kong. Frontiers in Microbiology, 7 (FEB) 216, 1-8. doi: 10.3389/fmicb.2016.00216

Combining prebiotics and probiotics to develop novel synbiotics that suppress oral pathogens

Kojima, Yukako, Ohshima, Tomoko, Seneviratne, Chaminda Jayampath and Maeda, Nobuko (2016). Combining prebiotics and probiotics to develop novel synbiotics that suppress oral pathogens. Journal of Oral Biosciences, 58 (1), 27-32. doi: 10.1016/j.job.2015.08.004

Editorial: Antifungal drug discovery: New theories and new therapies

Seneviratne, Chaminda J. and Rosa, Edvaldo A.R. (2016). Editorial: Antifungal drug discovery: New theories and new therapies. Frontiers in Microbiology, 7 (MAY) 728. doi: 10.3389/fmicb.2016.00728

Therapeutic application of synbiotics, a fusion of probiotics and prebiotics, and biogenics as a new concept for oral Candida infections: A mini review

Ohshima, Tomoko, Kojima, Yukako, Seneviratne, Chaminda J. and Maeda, Nobuko (2016). Therapeutic application of synbiotics, a fusion of probiotics and prebiotics, and biogenics as a new concept for oral Candida infections: A mini review. Frontiers in Microbiology, 7 (JAN) 00010. doi: 10.3389/fmicb.2016.00010

Enterococcus faecalis promotes osteoclastogenesis and semaphorin 4D expression

Wang, Shuai, Deng, Zuhui, Seneviratne, Chaminda J, Cheung, Gary Sp, Jin, Lijian, Zhao, Baohong and Zhang, Chengfei (2015). Enterococcus faecalis promotes osteoclastogenesis and semaphorin 4D expression. Innate Immunity, 21 (7), 726-735. doi: 10.1177/1753425915593162

Delicate metabolic control and coordinated stress response critically determine antifungal tolerance of Candida albicans biofilm persisters

Li, Peng, Seneviratne, Chaminda J., Alpi, Emanuele, Vizcaino, Juan A. and Jin, Lijian (2015). Delicate metabolic control and coordinated stress response critically determine antifungal tolerance of Candida albicans biofilm persisters. Antimicrobial Agents and Chemotherapy, 59 (10), 6101-6112. doi: 10.1128/AAC.00543-15

Impact of Actinomyces naeslundii on bisphosphonate-related osteonecrosis of the jaws in ovariectomized rats with periodontitis

Li, Chun Lei, Seneviratne, Chaminda Jayampath, Huo, Lei, Lu, Weijia William and Zheng, Li Wu (2015). Impact of Actinomyces naeslundii on bisphosphonate-related osteonecrosis of the jaws in ovariectomized rats with periodontitis. Journal of Cranio-Maxillofacial Surgery, 43 (8), 1662-1669. doi: 10.1016/j.jcms.2015.07.001

New "haploid biofilm model" unravels IRA2 as a novel regulator of Candida albicans biofilm formation

Seneviratne, Chaminda Jayampath, Zeng, Guisheng, Truong, Thuyen, Sze, Sarah, Wong, Wah, Samaranayake, Lakshman, Chan, Fong Yee, Wang, Yan-Ming, Wang, Haitao, Gao, Jiaxin and Wang, Yue (2015). New "haploid biofilm model" unravels IRA2 as a novel regulator of Candida albicans biofilm formation. Scientific Reports, 5 (1) 12433, 12433.1-12433.12. doi: 10.1038/srep12433

Antifungal susceptibility and phenotypic characterization of oral isolates of a black fungus from a nasopharyngeal carcinoma patient under radiotherapy

Seneviratne, Chaminda Jayampath, Fong, Phoenix, Wong, Sarah and Lee, Victor (2015). Antifungal susceptibility and phenotypic characterization of oral isolates of a black fungus from a nasopharyngeal carcinoma patient under radiotherapy. BMC Oral Health, 15 (1) 39. doi: 10.1186/s12903-015-0023-9

Candida albicans aspects of novel silane system-coated titanium and zirconia implant surfaces

Villard, Nicolas, Seneviratne, Chaminda, Tsoi, James Kit Hon, Heinonen, Markku and Matinlinna, Jukka (2015). Candida albicans aspects of novel silane system-coated titanium and zirconia implant surfaces. Clinical Oral Implants Research, 26 (3), 332-341. doi: 10.1111/clr.12338

Potential use of phenolic acids as anti-Candida agents: A review

Teodoro, Guilherme R., Ellepola, Kassapa, Seneviratne, Chaminda J. and Koga-Ito, Cristiane Y. (2015). Potential use of phenolic acids as anti-Candida agents: A review. Frontiers in Microbiology, 6 (DEC) 01420. doi: 10.3389/fmicb.2015.01420

Nanoparticle-encapsulated chlorhexidine against oral bacterial biofilms

Seneviratne, Chaminda Jayampath, Leung, Ken Cham-Fai, Wong, Chi-Hin, Lee, Siu-Fung, Li, Xuan, Leung, Ping Chung, Lau, Clara Bik San, Wat, Elaine and Jin, Lijian (2014). Nanoparticle-encapsulated chlorhexidine against oral bacterial biofilms. PLoS ONE, 9 (8) e103234. doi: 10.1371/journal.pone.0103234

In pursuit of the ideal antifungal agent for Candida infections: high-throughput screening of small molecules

Wong, Sarah S. W., Samaranayake, Lakshman P. and Senevirate, Chaminda J. (2014). In pursuit of the ideal antifungal agent for Candida infections: high-throughput screening of small molecules. Drug Discovery Today, 19 (11), 1721-1730. doi: 10.1016/j.drudis.2014.06.009

In vitro and in vivo activity of a novel antifungal small molecule against Candida infections

Wong, Sarah Sze Wah, Kao, Richard Yi Tsun, Yuen, Kwok Yong, Wang, Yu, Yang, Dan, Samaranayake, Lakshman Perera and Seneviratne, Chaminda Jayampath (2014). In vitro and in vivo activity of a novel antifungal small molecule against Candida infections. PLoS ONE, 9 (1) e85836, 1-17. doi: 10.1371/journal.pone.0085836

Biofilm formation of salivary microbiota on dental restorative materials analyzed by denaturing gradient gel electrophoresis and sequencing

Wang, Shuai, Guo, Lihong, Seneviratne, Chaminda Jayampath, Huang, Bo, Han, Jianmin, Peng, Lei, Liu, Xiaodi and Zhang, Chengfei (2014). Biofilm formation of salivary microbiota on dental restorative materials analyzed by denaturing gradient gel electrophoresis and sequencing. Dental Materials Journal, 33 (3), 325-331. doi: 10.4012/dmj.2013-152

Evaluation of the Candida albicans removal and mechanical properties of denture acrylics cleaned by a low-cost powered toothbrush

Tan, Chow-Ming, Tsoi, James Kit-Hon, Seneviratne, Chaminda Jayampath and Matinlinna, Jukka Pekka (2014). Evaluation of the Candida albicans removal and mechanical properties of denture acrylics cleaned by a low-cost powered toothbrush. Journal of Prosthodontic Research, 58 (4), 243-251. doi: 10.1016/j.jpor.2014.06.002

Natural compounds containing mouthrinses in the management of dental plaque and gingivitis: A systematic review

Chen, Yong, Wong, Ricky W.K., McGrath, Colman, Hagg, Urban and Seneviratne, C. Jayampath (2014). Natural compounds containing mouthrinses in the management of dental plaque and gingivitis: A systematic review. Clinical Oral Investigations, 18 (1), 1-16. doi: 10.1007/s00784-013-1033-0

The expression and regulation of matrix metalloproteinase-3 is critically modulated by Porphyromonas gingivalis lipopolysaccharide with heterogeneous lipid A structures in human gingival fibroblasts

Herath, Thanuja D. K., Wang, Yu, Seneviratne, Chaminda J, Darveau, Richard P, Wang, Cun-Yu and Jin, Lijian (2013). The expression and regulation of matrix metalloproteinase-3 is critically modulated by Porphyromonas gingivalis lipopolysaccharide with heterogeneous lipid A structures in human gingival fibroblasts. BMC Microbiology, 13 (1) 73. doi: 10.1186/1471-2180-13-73

Tetra- and Penta-Acylated Lipid A Structures of Porphyromonas gingivalis LPS Differentially Activate TLR4-Mediated NF-κB Signal Transduction Cascade and Immuno-Inflammatory Response in Human Gingival Fibroblasts

Herath, Thanuja D. K., Darveau, Richard P., Seneviratne, Chaminda J., Wang, Cun-Yu, Wang, Yu and Jin, Lijian (2013). Tetra- and Penta-Acylated Lipid A Structures of Porphyromonas gingivalis LPS Differentially Activate TLR4-Mediated NF-κB Signal Transduction Cascade and Immuno-Inflammatory Response in Human Gingival Fibroblasts. PLoS ONE, 8 (3) e58496. doi: 10.1371/journal.pone.0058496

Endodontic bacteria from primary and persistent endodontic lesions in Chinese patients as identified by cloning and 16S ribosomal DNA gene sequencing

Li, Xin, Zhu, Xiao-Fei, Zhang, Cheng-Fei, Cathro, Peter, Seneviratne, C. J. and Shen, Song (2013). Endodontic bacteria from primary and persistent endodontic lesions in Chinese patients as identified by cloning and 16S ribosomal DNA gene sequencing. Chinese Medical Journal, 126 (4), 634-639. doi: 10.3760/cma.j.issn.0366-6999.20122285

Unraveling the resistance of microbial biofilms: Has proteomics been helpful?

Seneviratne, C. Jayampath, Wang, Yu, Jin, Lijian, Wong, Sarah S. W., Herath, Thanuja D. K. and Samaranayake, Lakshman P. (2012). Unraveling the resistance of microbial biofilms: Has proteomics been helpful?. Proteomics, 12 (4-5), 651-665. doi: 10.1002/pmic.201100356

Effects of silver diamine fluoride on dentine carious lesions induced by Streptococcus mutans and Actinomyces naeslundii biofilms

Chu, Chun Hung, Mei, Lei, Seneviratne, Chaminda Jayampath and Lo, Edward Chin Man (2012). Effects of silver diamine fluoride on dentine carious lesions induced by Streptococcus mutans and Actinomyces naeslundii biofilms. International Journal of Paediatric Dentistry, 22 (1), 2-10. doi: 10.1111/j.1365-263X.2011.01149.x

Exopolysaccharide matrix of developed Candida albicans biofilms after exposure to antifungal agents

Da Silva, Wander Jose, Goncalves, Letícia Machado, Seneviratne, Jayampath, Parahitiyawa, Nipuna, Samaranayake, Lakshman Perera and Del Bel Cury, Altair Antoninha (2012). Exopolysaccharide matrix of developed Candida albicans biofilms after exposure to antifungal agents. Brazilian Dental Journal, 23 (6), 716-722. doi: 10.1590/S0103-64402012000600016

Antifungal Susceptibility and Virulence Attributes of Bloodstream Isolates of Candida from Hong Kong and Finland

Seneviratne, C. J., Wong, S. S. W., Yuen, K. Y., Meurman, J. H., Parnanen, P., Vaara, M. and Samaranayake, L. P. (2011). Antifungal Susceptibility and Virulence Attributes of Bloodstream Isolates of Candida from Hong Kong and Finland. Mycopathologia, 172 (5), 389-395. doi: 10.1007/s11046-011-9444-4

Transcriptional regulation of drug-resistance genes in Candida albicans biofilms in response to antifungals

Watamoto, T., Samaranayake, L. P., Egusa, H., Yatani, H. and Seneviratne, C. J. (2011). Transcriptional regulation of drug-resistance genes in Candida albicans biofilms in response to antifungals. Journal of Medical Microbiology, 60 (9), 1241-1247. doi: 10.1099/jmm.0.030692-0

Antimicrobial activity of Chinese medicine herbs against common bacteria in oral biofilm. A pilot study

Wong, R. W.K., Hägg, U., Samaranayake, L., Yuen, M. K.Z., Seneviratne, C. J. and Kao, R. (2010). Antimicrobial activity of Chinese medicine herbs against common bacteria in oral biofilm. A pilot study. International Journal of Oral and Maxillofacial Surgery, 39 (6), 599-605. doi: 10.1016/j.ijom.2010.02.024

Biomarker discovery in clinical proteomics: Strategies for exposing low abundant proteins

Wang, Yu and Seneviratne, Jayampath (2008). Biomarker discovery in clinical proteomics: Strategies for exposing low abundant proteins. Current Proteomics, 5 (2), 104-114. doi: 10.2174/157016408784911927

An overview of H5n1 infection and its implications for dentistry

Seneviratne, C. J. and Samaranayake, L. P. (2008). An overview of H5n1 infection and its implications for dentistry. International Journal of Clinical Dentistry, 1 (1), 27-44.

Improvement of XTT assay performance for studies involving Candida albicans biofilms

da Silva, Wander José, Seneviratne, Jayampath, Parahitiyawa, Nipuna, Rosa, Edvaldo Antonio Ribeiro, Samaranayake, Lakshman Perera and del Bel Cury, Altair Antoninha (2008). Improvement of XTT assay performance for studies involving Candida albicans biofilms. Brazilian Dental Journal, 19 (4), 364-369. doi: 10.1590/s0103-64402008000400014