The University of Queensland

A TfR-Binding Cystine-Dense Peptide Promotes Blood-Brain Barrier Penetration of Bioactive Molecules

Crook, Zachary R., Girard, Emily, Sevilla, Gregory P., Merrill, Morgan, Friend, Della, Rupert, Peter B., Pakiam, Fiona, Nguyen, Elizabeth, Yin, Chunfeng, Ruff, Raymond O., Hopping, Gene, Strand, Andrew D., Finton, Kathryn A. K., Coxon, Margo, Mhyre, Andrew J., Strong, Roland K. and Olson, James M. (2020). A TfR-Binding Cystine-Dense Peptide Promotes Blood-Brain Barrier Penetration of Bioactive Molecules. Journal of Molecular Biology, 432 (14), 3989-4009. doi: 10.1016/j.jmb.2020.04.002

A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure

Sangar, Michelle L. Cook, Girard, Emily J., Hopping, Gene, Yin, Chunfeng, Pakiam, Fiona, Brusniak, Mi-Youn, Nguyen, Elizabeth, Ruff, Raymond, Gewe, Mesfin M., Byrnes-Blake, Kelly, Nairn, Natalie W., Miller, Dennis M., Mehlin, Christopher, Strand, Andrew D., Mhyre, Andrew J., Correnti, Colin E., Strong, Roland K., Simon, Julian A. and Olson, James M. (2020). A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure. Science Translational Medicine, 12 (533) eaay1041. doi: 10.1126/scitranslmed.aay1041

Pacifastin-derived Peptides Target Tumors for Use in In Vivo Imaging

Sottero, Theo L., Girard, Emily J., Myers, Carrie, Hopping, Gene, Mhyre, Andrew J. and Olson, James M. (2018). Pacifastin-derived Peptides Target Tumors for Use in In Vivo Imaging. Anticancer Research, 38 (1), 51-60. doi: 10.21873/anticanres.12191

Peptides Composed of Alternating L- and D-Amino Acids Inhibit Amyloidogenesis in Three Distinct Amyloid Systems Independent of Sequence

Kellock, Jackson, Hopping, Gene, Caughey, Byron and Daggett, Valerie (2016). Peptides Composed of Alternating L- and D-Amino Acids Inhibit Amyloidogenesis in Three Distinct Amyloid Systems Independent of Sequence. Journal of Molecular Biology, 428 (11), 2317-2328. doi: 10.1016/j.jmb.2016.03.013

Nature versus design: the conformational propensities of d-amino acids and the importance of side chain chirality

Towse, Clare-Louise, Hopping, Gene, Vulovic, Ivan and Daggett, Valerie (2014). Nature versus design: the conformational propensities of d-amino acids and the importance of side chain chirality. Protein Engineering Design and Selection, 27 (11), 447-455. doi: 10.1093/protein/gzu037

Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers

Hopping, Gene, Kellock, Jackson, Barnwal, Ravi Pratap, Law, Peter, Bryers, James, Varani, Gabriele, Caughey, Byron and Daggett, Valerie (2014). Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers. eLife, 2014 (3) e01681. doi: 10.7554/elife.01681

Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors

Hopping, Gene, Wang, C-I Anderson, Hogg, Ron C., Nevin, Simon T., Lewis, Richard J., Adams, David J. and Alewood, Paul F. (2014). Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors. Biochemical Pharmacology, 91 (4), 534-542. doi: 10.1016/j.bcp.2014.07.025

Designed Trpzip-3 beta-Hairpin Inhibits Amyloid Formation in Two Different Amyloid Systems

Hopping, Gene, Kellock, Jackson, Caughey, Byron and Daggett, Valerie (2013). Designed Trpzip-3 beta-Hairpin Inhibits Amyloid Formation in Two Different Amyloid Systems. Acs Medicinal Chemistry Letters, 4 (9), 824-828. doi: 10.1021/ml300478w

Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding

Dantas de Araujo, Aline, Callaghan, Brid, Nevin, Simon T., Daly, Norelle L., Craik, David J., Moretta, Melissa, Hopping, Gene, Christie, Macdonald J., Adams, David J. and Alewood, Paul F. (2011). Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angewandte Chemie (International Edition), 50 (29), 6527-6529. doi: 10.1002/anie.201101642

Benzhydrylamine linker grafting: A strategy for the improved synthesis of C-terminal peptide amides

Alewood, Dianne, Hopping, Gene, Brust, Andreas, Reid, Robert C. and Alewood, Paul F. (2010). Benzhydrylamine linker grafting: A strategy for the improved synthesis of C-terminal peptide amides. Journal of Peptide Science, 16 (10), 551-557. doi: 10.1002/psc.1248

Rapid access to omega conotoxin chimeras using native chemical ligation

Hopping , Gene, Lewis, Richard J. and Alewood, Paul F. (2009). Rapid access to omega conotoxin chimeras using native chemical ligation. Austalian Journal of Chemistry, 62 (10), 1333-1338. doi: 10.1071/CH09216

AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

Dutertre, S., Ulens, C, Buttner, R, Fish, A, van Elk, R, Kendel, Y, Hopping, G., Alewood, P. F., Schroeder, C., Nicke, A, Smit, AB, Sixma, TK and Lewis, R. J. (2007). AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. Embo Journal, 26 (16), 3858-3867. doi: 10.1038/sj.emboj.7601785

alpha-conotoxins PnIA and [A10L] PnIA stabilize different states of the alpha 7-L247T nicotinic acetylcholine receptor

Hogg, R. C., Hopping, G., Alewood, P. F., Adams, D. J. and Bertrand, D. (2003). alpha-conotoxins PnIA and [A10L] PnIA stabilize different states of the alpha 7-L247T nicotinic acetylcholine receptor. Journal of Biological Chemistry, 278 (29), 26908-26914. doi: 10.1074/jbc.M212628200

Marine toxins as sources of drug leads

Alewood, P., Hopping, G. and Armishaw, C. (2003). Marine toxins as sources of drug leads. Australian Journal of Chemistry, 56 (8), 769-774. doi: 10.1071/CH03043

Structural studies of AChBP, a soluble nicotinic acetylcholine receptor homolog, in complex with novel ligands

Ulens, Chris, Dutertre, Sebastien, Hopping, Gene, Fish, Alex, Schroeder, Christina, van Elk, Rene, Akdemir, Atilla, de Esch, Iwan, Nicke, Annette, Alewood, Paul, Lewis, Richard, Smit, August B. and Perrakis, Anastassis (2007). Structural studies of AChBP, a soluble nicotinic acetylcholine receptor homolog, in complex with novel ligands. 51st Annual Meeting of the Biophysical Society, Baltimore, MD United States, 3-7 March 2007. Cambridge, United Kingdom: Cell Press.