Dr Ismail Sebina

Senior Research Officer

Frazer Institute
Faculty of Medicine

Honorary Research Fellow

School of Biomedical Sciences
Faculty of Medicine

Overview

Dr Ismail Sebina is a Research Fellow at the Frazer Institute-The University of Queensland, under the mentorship of Prof. Gabrielle Belz. He holds a PhD in immunology from The University of Queensland (awarded in 2017) and a Master’s degree in the Immunology of Infectious Diseases from the London School of Hygiene and Tropical Medicine (LSHTM; UK). He has contributed to discovery and translational immunological research in several laboratories across the USA, the UK, Uganda, and Australia, implementing studies in both preclinical mouse models and humans. He completed six years of rigorous postdoctoral training in immunology at the University of Washington (USA) and QIMR Berghofer Medical Research institute (QIMR Berghofer; Australia). He has demonstrated a strong record of publications in high-impact journals such as Immunity, Science Immunology, JCI and PNAS. He has regularly presented his findings at national and international conferences (e.g. Keystone Symposium and ASI), furthering my engagement with the scientific community. Dr. Sebina's primary research focus revolves around uncovering the mechanisms that underpin natural and vaccine-induced immunity to infections. With a passion for improving maternal, newborn, and child health, he also explores novel immunological strategies that have the potential to revolutionize healthcare practices in this area.

Research Interests

  • Infection and Immunity
  • Immunology of Infectious Diseases
  • Maternal-Newborn Immunity
  • Vaccine Immunology
  • Humoral immunity

Qualifications

  • Doctor of Philosophy of Immunology, The University of Queensland
  • Masters (Extended) of Immunology
  • Bachelor (Honours) of Biomedical Science, Makerere University

Publications

  • Sebina, Ismail, Ngo, Sylvia, Rashid, Ridwan B., Alorro, Mariah, Namubiru, Patricia, Howard, Daniel, Ahmed, Tufael and Phipps, Simon (2024). CXCR3+ effector regulatory T cells associate with disease tolerance during lower respiratory pneumovirus infection. Immunology. doi: 10.1111/imm.13790

  • Stylianou, Nataly, Sebina, Ismail, Matigian, Nicholas, Monkman, James, Doehler, Hadeel, Röhl, Joan, Allenby, Mark, Nam, Andy, Pan, Liuliu, Rockstroh, Anja, Sadeghirad, Habib, Chung, Kimberly, Sobanski, Thais, O'Byrne, Ken, Almeida, Ana Clara Simoes Florido, Rebutini, Patricia Zadorosnei, Machado‐Souza, Cleber, Stonoga, Emanuele Therezinha Schueda, Warkiani, Majid E, Salomon, Carlos, Short, Kirsty, McClements, Lana, de Noronha, Lucia, Huang, Ruby, Belz, Gabrielle T, Souza‐Fonseca‐Guimaraes, Fernando, Clifton, Vicki and Kulasinghe, Arutha (2024). Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures. Clinical & Translational Immunology, 13 (2) e1488, e1488. doi: 10.1002/cti2.1488

  • Agravat, Priyesh, Loucaides, Eva M, Kumar, Meghan Bruce, Howells, Anna, García, Alexandra Molina, Sebina, Ismail, Balanza, Núria, Fitchett, Elizabeth J A and Lawn, Joy E (2023). Research funding for newborn health and stillbirths, 2011–20: a systematic analysis of levels and trends. The Lancet Global Health, 11 (11), e1794-e1804. doi: 10.1016/s2214-109x(23)00379-0

View all Publications

Publications

Journal Article

  • Sebina, Ismail, Ngo, Sylvia, Rashid, Ridwan B., Alorro, Mariah, Namubiru, Patricia, Howard, Daniel, Ahmed, Tufael and Phipps, Simon (2024). CXCR3+ effector regulatory T cells associate with disease tolerance during lower respiratory pneumovirus infection. Immunology. doi: 10.1111/imm.13790

  • Stylianou, Nataly, Sebina, Ismail, Matigian, Nicholas, Monkman, James, Doehler, Hadeel, Röhl, Joan, Allenby, Mark, Nam, Andy, Pan, Liuliu, Rockstroh, Anja, Sadeghirad, Habib, Chung, Kimberly, Sobanski, Thais, O'Byrne, Ken, Almeida, Ana Clara Simoes Florido, Rebutini, Patricia Zadorosnei, Machado‐Souza, Cleber, Stonoga, Emanuele Therezinha Schueda, Warkiani, Majid E, Salomon, Carlos, Short, Kirsty, McClements, Lana, de Noronha, Lucia, Huang, Ruby, Belz, Gabrielle T, Souza‐Fonseca‐Guimaraes, Fernando, Clifton, Vicki and Kulasinghe, Arutha (2024). Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures. Clinical & Translational Immunology, 13 (2) e1488, e1488. doi: 10.1002/cti2.1488

  • Agravat, Priyesh, Loucaides, Eva M, Kumar, Meghan Bruce, Howells, Anna, García, Alexandra Molina, Sebina, Ismail, Balanza, Núria, Fitchett, Elizabeth J A and Lawn, Joy E (2023). Research funding for newborn health and stillbirths, 2011–20: a systematic analysis of levels and trends. The Lancet Global Health, 11 (11), e1794-e1804. doi: 10.1016/s2214-109x(23)00379-0

  • Curren, Bodie, Ahmed, Tufael, Howard, Daniel R., Ashik Ullah, Md., Sebina, Ismail, Rashid, Ridwan B., Al Amin Sikder, Md., Namubiru, Patricia, Bissell, Alec, Ngo, Sylvia, Jackson, David J, Toussaint, Marie, Edwards, Michael R., Johnston, Sebastian L, McSorley, Henry J. and Phipps, Simon (2023). IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma. Mucosal Immunology, 16 (5), 671-684. doi: 10.1016/j.mucimm.2023.07.002

  • Sikder, Md. Al Amin, Rashid, Ridwan B., Ahmed, Tufael, Sebina, Ismail, Howard, Daniel R., Ullah, Md. Ashik, Rahman, Muhammed Mahfuzur, Lynch, Jason P., Curren, Bodie, Werder, Rhiannon B., Simpson, Jennifer, Bissell, Alec, Morrison, Mark, Walpole, Carina, Radford, Kristen J., Kumar, Vinod, Woodruff, Trent M., Ying, Tan Hui, Ali, Ayesha, Kaiko, Gerard E., Upham, John W., Hoelzle, Robert D., Cuív, Páraic Ó., Holt, Patrick G., Dennis, Paul G. and Phipps, Simon (2023). Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection. Immunity, 56 (5), 1098-1114.e10. doi: 10.1016/j.immuni.2023.03.002

  • Sebina, Ismail, Rashid, Ridwan B., Sikder, Md. Al Amin, Rahman, Muhammed Mahfuzur, Ahmed, Tufael, Radford-Smith, Daniel E., Kotenko, Sergei V., Hill, Geoffrey R., Bald, Tobias and Phipps, Simon (2022). IFN-λ diminishes the severity of viral bronchiolitis in neonatal mice by limiting NADPH oxidase–induced PAD4-independent NETosis. The Journal of Immunology, 208 (12), 2806-2816. doi: 10.4049/jimmunol.2100876

  • Manna, Sam, McAuley, Julie, Jacobson, Jonathan, Nguyen, Cattram D., Ullah, Md Ashik, Sebina, Ismail, Williamson, Victoria, Mulholland, E. Kim, Wijburg, Odilia, Phipps, Simon and Satzke, Catherine (2022). Synergism and antagonism of bacterial-viral coinfection in the upper respiratory tract. mSphere, 7 (1) e00984-21. doi: 10.1128/msphere.00984-21

  • Werder, Rhiannon B., Ullah, Md Ashik, Rahman, Muhammed Mahfuzur, Simpson, Jennifer, Lynch, Jason P., Collinson, Natasha, Rittchen, Sonja, Rashid, Ridwan B., Sikder, Md Al Amin, Handoko, Herlina Y., Curren, Bodie F., Sebina, Ismail, Hartel, Gunter, Bissell, Alec, Ngo, Sylvia, Yarlagadda, Tejasri, Hasnain, Sumaira Z., Lu, Wenying, Sohal, Sukhwinder S., Martin, Megan, Bowler, Simon, Burr, Lucy D., Martinez, Laurent O., Robaye, Bernard, Spann, Kirsten, Ferreira, Manuel A. R. and Phipps, Simon (2022). Targeting the P2Y13 receptor suppresses IL-33 and HMGB1 release and ameliorates experimental asthma. American Journal of Respiratory and Critical Care Medicine, 205 (3), 300-312. doi: 10.1164/rccm.202009-3686oc

  • Kimuda, Simon G., Andia-Biraro, Irene, Sebina, Ismail, Egesa, Moses, Nalwoga, Angela, Smith, Steven G., Bagaya, Bernard S., Levin, Jonathan, Elliott, Alison M., Raynes, John G. and Cose, Stephen (2020). Mycobacterium tuberculosis infection is associated with increased B cell responses to unrelated pathogens. Scientific Reports, 10 (1) 14324, 14324. doi: 10.1038/s41598-020-71044-4

  • Sebina, Ismail and Phipps, Simon (2020). The contribution of neutrophils to the pathogenesis of RSV bronchiolitis. Viruses, 12 (8) 808, 808. doi: 10.3390/v12080808

  • Lynch, Jason P., Werder, Rhiannon B., Curren, Bodie F., Sikder, Md. Al Amin, Ullah, Ashik, Sebina, Ismail, Rashid, Ridwan B., Zhang, Vivian, Upham, John W., Hill, Geoff R., Steptoe, Raymond J. and Phipps, Simon (2020). Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma. Mucosal Immunology, 13 (4), 652-664. doi: 10.1038/s41385-020-0268-8

  • Ullah, Md Ashik, Vicente, Cristina T., Collinson, Natasha, Curren, Bodie, Sikder, Md Al Amin, Sebina, Ismail, Simpson, Jennifer, Varelias, Antiopi, Lindquist, Jonathan A., Ferreira, Manuel A. R. and Phipps, Simon (2020). PAG1 limits allergen-induced type 2 inflammation in the murine lung. Allergy, 75 (2) all.13991, 336-345. doi: 10.1111/all.13991

  • Akter, Jasmin, Khoury, David S., Aogo, Rosemary, Lansink, Lianne I. M., SheelaNair, Arya, Thomas, Bryce S., Laohamonthonkul, Pawat, Pernold, Clara P. S., Dixon, Matthew W. A., Soon, Megan S. F., Fogg, Lily G., Engel, Jessica A., Elliott, Trish, Sebina, Ismail, James, Kylie R., Cromer, Deborah, Davenport, Miles P. and Haque, Ashraful (2019). Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells. PLoS Pathogens, 15 (2) e1007599, e1007599. doi: 10.1371/journal.ppat.1007599

  • Newton, Robert, Labo, Nazzarena, Wakeham, Katie, Marshall, Vickie, Roshan, Romin, Nalwoga, Angela, Sebina, Ismail, Muhangi, Lawrence, Webb, Emily L., Miley, Wendell, Rochford, Rosemary, Elliott, Alison M. and Whitby, Denise (2018). Determinants of gammaherpesvirus shedding in saliva among Ugandan children and their mothers. Journal of Infectious Diseases, 218 (6), 892-900. doi: 10.1093/infdis/jiy262

  • Sebina, Ismail and Haque, Ashraful (2018). Effects of type I interferons in malaria. Immunology, 155 (2), 176-185. doi: 10.1111/imm.12971

  • Sebina, Ismail and Pepper, Marion (2018). Humoral immune responses to infection: common mechanisms and unique strategies to combat pathogen immune evasion tactics. Current Opinion in Immunology, 51, 46-54. doi: 10.1016/j.coi.2018.02.001

  • James, Kylie R., Soon, Megan S. F., Sebina, Ismail, Fernandez-Ruiz, Daniel, Davey, Gayle, Liligeto, Urijah N., Nair, Arya Sheela, Fogg, Lily G., Edwards, Chelsea L., Best, Shannon E., Lansink, Lianne I. M., Schroder, Kate, Wilson, Jane A. C., Austin, Rebecca, Suhrbier, Andreas, Lane, Steven W., Hill, Geoffrey R., Engwerda, Christian R., Heath, William R. and Haque, Ashraful (2018). IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infection. Journal of Immunology, 200 (4), 1443-1456. doi: 10.4049/jimmunol.1700782

  • Khoury, David S., Cromer, Deborah, Elliott, Trish, Soon, Megan S. F., Thomas, Bryce S., James, Kylie R., Best, Shannon E., Aogo, Rosemary A., Engel, Jessica A., Gartlan, Kate H., Akter, Jasmin, Sebina, Ismail, Haque, Ashraful and Davenport, Miles P. (2017). Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo. International Journal for Parasitology, 47 (14), 913-922. doi: 10.1016/j.ijpara.2017.05.009

  • Sebina, I., Fogg, L. G., James, K. R., Soon, M. S. F., Akter, J., Thomas, B. S., Hill, G. R., Engwerda, C. R. and Haque, A. (2017). IL-6 promotes CD4(+) T-cell and B-cell activation during Plasmodium infection. Parasite Immunology, 39 (10) e12455, e12455. doi: 10.1111/pim.12455

  • Khoury, David S., Cromer, Deborah, Akter, Jasmin, Sebina, Ismail, Elliott, Trish, Thomas, Bryce S., Soon, Megan S. F., James, Kylie R., Best, Shannon E., Haque, Ashraful and Davenport, Miles P. (2017). Host-mediated impairment of parasite maturation during blood-stage Plasmodium infection. Proceedings of the National Academy of Sciences of the United States of America, 114 (29), 7701-7706. doi: 10.1073/pnas.1618939114

  • Lönnberg, Tapio, Svensson, Valentine, James, Kylie R., Fernandez-Ruiz, Daniel, Sebina, Ismail, Montandon, Ruddy, Soon, Megan S. F., Fogg, Lily G., Nair, Arya Sheela, Liligeto, Urijah N., Stubbington, Michael J. T., Ly, Lam-Ha, Bagger, Frederik Otzen, Zwiessele, Max, Lawrence, Neil D., Souza-Fonseca-Guimaraes, Fernando, Bunn, Patrick T., Engwerda, Christian R., Heath, William R., Billker, Oliver, Stegle, Oliver, Haque, Ashraful and Teichmann, Sarah A. (2017). Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves TH1/TFHfate bifurcation in malaria. Science Immunology, 2 (9) eaal2192, eaal2192. doi: 10.1126/sciimmunol.aal2192

  • Sebina, Ismail, James, Kylie R., Soon, Megan S. F., Fogg, Lily G., Best, Shannon E., Labastida Rivera, Fabian de, Montes de Oca, Marcela, Amante, Fiona H., Thomas, Bryce S., Beattie, Lynette, Souza-Fonseca-Guimaraes, Fernando, Smyth, Mark J., Hertzog, Paul J., Hill, Geoffrey R., Hutloff, Andreas, Engwerda, Christian R. and Haque, Ashraful (2016). IFNAR1-signalling obstructs ICOS-mediated humoral immunity during non-lethal blood-stage Plasmodium infection. PLoS Pathogens, 12 (11) e1005999, e1005999. doi: 10.1371/journal.ppat.1005999

  • Khoury, David S., Cromer, Deborah, Best, Shannon E., James, Kylie R., Sebina, Ismail, Haque, Ashraful and Davenport, Miles P. (2015). Reduced erythrocyte susceptibility and increased host clearance of young parasites slows Plasmodium growth in a murine model of severe malaria. Scientific Reports, 5 (9412) 9412. doi: 10.1038/srep09412

  • Edwards, Chelsea L., Zhang, Vivian, Werder, Rhiannon B., Best, Shannon E., Sebina, Ismail, James, Kylie R., Faleiro, Rebecca J., Rivera, Fabian de Labastida, Amante, Fiona H., Engwerda, Christian R., Phipps, Simon and Haque, Ashraful (2015). Coinfection with blood-stage plasmodium promotes systemic type I interferon production during pneumovirus infection but impairs inflammation and viral control in the lung. Clinical and Vaccine Immunology, 22 (5), 477-483. doi: 10.1128/CVI.00051-15

  • Edwards, Chelsea L., Best, Shannon E., Gun, Sin Yee, Claser, Carla, James, Kylie R., de Oca, Marcela M., Sebina, Ismail, Rivera, Fabian de Labastida, Amante, Fiona H., Hertzog, Paul J., Engwerda, Christian R., Renia, Laurent and Haque, Ashraful (2015). Spatiotemporal requirements for IRF7 in mediating type I IFN-dependent susceptibility to blood-stage Plasmodium infection. European Journal of Immunology, 45 (1), 130-141. doi: 10.1002/eji.201444824

  • Sebina, Ismail, Biraro, Irene A., Dockrell, Hazel M., Elliott, Alison M. and Cose, Stephen (2014). Circulating B-lymphocytes as potential biomarkers of tuberculosis infection activity. PLoS One, 9 (9) e106796, e106796. doi: 10.1371/journal.pone.0106796

  • Haque, Ashraful, Best, Shannon E., De Oca, Marcela Montes, James, Kylie R., Ammerdorffer, Anne, Edwards, Chelsea L., De Labastida Rivera, Fabian, Amante, Fiona H., Bunn, Patrick T., Sheel, Meru, Sebina, Ismail, Koyama, Motoko, Varelias, Antiopi, Hertzog, Paul J., Kalinke, Ulrich, Gun, Sin Yee, Renia, Laurent, Ruedl, Christiane, MacDonald, Kelli P.A., Hill, Geoffrey R. and Engwerda, Christian R. (2014). Type I IFN signaling in CD8-DCs impairs Th1-dependent malaria immunity. Journal of Clinical Investigation, 124 (6), 2483-2496. doi: 10.1172/JCI70698

  • Sebina, Ismail, Cliff, Jacqueline M., Smith, Steven G., Nogaro, Sarah, Webb, Emily L., Riley, Eleanor M., Dockrell, Hazel M., Elliott, Alison M., Hafalla, Julius C. R. and Cose, Stephen (2012). Long-lived memory B-cell responses following BCG vaccination. PLoS One, 7 (12), e51381. doi: 10.1371/journal.pone.0051381

  • Nkurunungi, Gyaviira, Lutangira, Jimreeves E., Lule, Swaib A., Akurut, Hellen, Kizindo, Robert, Fitchett, Joseph R., Kizito, Dennison, Sebina, Ismail, Muhangi, Lawrence, Webb, Emily L., Cose, Stephen and Elliott, Alison M. (2012). Determining Mycobacterium tuberculosis infection among BCG-immunised Ugandan children by T-SPOT.TB and tuberculin skin testing. PLoS One, 7 (10) e47340, e47340. doi: 10.1371/journal.pone.0047340

  • Wakeham, Katie, Webb, Emily L., Sebina, Ismail, Muhangi, Lawrence, Miley, Wendell, Johnson, W. Thomas, Ndibazza, Juliet, Elliott, Alison M., Whitby, Denise and Newton, Robert (2011). Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women. Infectious Agents and Cancer, 6 (1) 15, 15. doi: 10.1186/1750-9378-6-15

Conference Publication

Other Outputs

PhD and MPhil Supervision

Completed Supervision