The University of Queensland

Rapid whole‐blood assay to detect SARS‐CoV‐2‐specific memory T‐cell immunity following a single dose of AstraZeneca ChAdOx1‐S COVID‐19 vaccine

Lineburg, Katie E, Neller, Michelle A, Ambalathingal, George R, Le Texier, Laetitia, Raju, Jyothy, Swaminathan, Srividhya, Lekieffre, Lea, Smith, Caitlyn, Rehan, Sweera, Crooks, Pauline, Panikkar, Archana, Srihari, Sriganesh, Khanna, Rajiv and Smith, Corey (2021). Rapid whole‐blood assay to detect SARS‐CoV‐2‐specific memory T‐cell immunity following a single dose of AstraZeneca ChAdOx1‐S COVID‐19 vaccine. Clinical and Translational Immunology, 10 (8) e1326, 1-7. doi: 10.1002/cti2.1326

Identification of SARS-CoV-2 nucleocapsid and spike T-cell epitopes for assessing T-cell immunity

Lee, Eunok, Sandgren, Kerrie, Duette, Gabriel, Stylianou, Vicki V., Khanna, Rajiv, Eden, John-Sebastian, Blyth, Emily, Gottlieb, David, Cunningham, Anthony L. and Palmera, Sarah (2021). Identification of SARS-CoV-2 nucleocapsid and spike T-cell epitopes for assessing T-cell immunity. Journal of Virology, 95 (6) 02002. doi: 10.1128/JVI.02002-20

EBV and myeloid-derived suppressor cells

Sinha, Debottam and Khanna, Rajiv (2021). EBV and myeloid-derived suppressor cells. Blood, 137 (2), 148-150. doi: 10.1182/blood.2020008640

'Off-the-shelf' allogeneic antigen-specific adoptive T-cell therapy for the treatment of multiple EBV-associated malignancies

Sinha, Debottam, Srihari, Sriganesh, Beckett, Kirrliee, Le Texier, Laetitia, Solomon, Matthew, Panikkar, Archana, Ambalathingal, George R., Lekieffre, Lea, Crooks, Pauline, Rehan, Sweera, Neller, Michelle A., Smith, Corey and Khanna, Rajiv (2021). 'Off-the-shelf' allogeneic antigen-specific adoptive T-cell therapy for the treatment of multiple EBV-associated malignancies. Journal for Immunotherapy of Cancer, 9 (2), e001608. doi: 10.1136/jitc-2020-001608

Pre-transplant cytomegalovirus-specific cellular immunity and risk of viral reactivation following lung transplantation: a prospective cohort study

Altaf, Mohammed, Lineburg, Katie E., Crooks, Pauline, Rehan, Sweera, Matthews, Katherine K., Neller, Michelle A, Ambalathingal, George R., Sinha, Debottam, Grant, Michelle, Hopkins, Peter M. A., Chambers, Daniel, Khanna, Rajiv and Smith, Corey (2020). Pre-transplant cytomegalovirus-specific cellular immunity and risk of viral reactivation following lung transplantation: a prospective cohort study. The Journal of infectious diseases, 224 (2), 312-317. doi: 10.1093/infdis/jiaa750

Epstein-Barr virus-specific T cell therapy for progressive multiple sclerosis

Pender, Michael P., Csurhes, Peter A., Smith, Corey, Douglas, Nanette L., Neller, Michelle A., Matthews, Katherine K., Beagley, Leone, Rehan, Sweera, Crooks, Pauline, Hopkins, Tracey J., Blum, Stefan, Green, Kerryn A., Ioannides, Zara A., Swayne, Andrew, Aftab, Blake T., Hooper, Kaye D., Burrows, Scott R., Thompson, Kate M., Coulthard, Alan and Khanna, Rajiv (2020). Epstein-Barr virus-specific T cell therapy for progressive multiple sclerosis. JCI insight, 5 (20) e144624. doi: 10.1172/jci.insight.144624

Proteome-wide analysis of T-cell response to BK polyomavirus in healthy virus carriers and kidney transplant recipients reveals a unique transcriptional and functional profile

Ambalathingal, George R., Francis, Ross S., Corvino, Dillon, Srihari, Sriganesh, Aftab, Blake T., Smith, Corey and Khanna, Rajiv (2020). Proteome-wide analysis of T-cell response to BK polyomavirus in healthy virus carriers and kidney transplant recipients reveals a unique transcriptional and functional profile. Clinical and Translational Immunology, 9 (1) e01102. doi: 10.1002/cti2.1102

Joining Forces: Improving Clinical Response to Cellular Immunotherapies with Small-Molecule Inhibitors

Sinha, Debottam, Smith, Corey and Khanna, Rajiv (2020). Joining Forces: Improving Clinical Response to Cellular Immunotherapies with Small-Molecule Inhibitors. Trends in Molecular Medicine, 27 (1), 75-90. doi: 10.1016/j.molmed.2020.09.005

Rapid detection of SARS‐CoV‐2‐specific memory T‐cell immunity in recovered COVID‐19 cases

Lineburg, Katie E., Srihari, Sriganesh, Altaf, Mohammed, Swaminathan, Srividhya, Panikkar, Archana, Raju, Jyothy, Crooks, Pauline, Ambalathingal, George R., Martins, Jose Paulo, Matthews, Katherine K., Neller, Michelle A., Khanna, Rajiv and Smith, Corey (2020). Rapid detection of SARS‐CoV‐2‐specific memory T‐cell immunity in recovered COVID‐19 cases. Clinical and Translational Immunology, 9 (12) e1219, e1219. doi: 10.1002/cti2.1219

T cell repertoire remodelling following post-transplant T cell therapy coincides with clinical response

Smith, Corey, Corvino, Dillon, Beagley, Leone, Rehan, Sweera, Neller, Michelle A., Crooks, Pauline, Matthews, Katherine K., Solomon, Matthew, Le Texier, Laetitia, Campbell, Scott, Francis, Ross S., Chambers, Daniel and Khanna, Rajiv (2019). T cell repertoire remodelling following post-transplant T cell therapy coincides with clinical response. Journal of Clinical Investigation, 129 (11), 5020-5032. doi: 10.1172/jci128323

Impact of pre-therapy glioblastoma multiforme microenvironment on clinical response to autologous CMV-specific T-cell therapy

Walker, David G., Shakya, Reshma, Morrison, Beth, Neller, Michelle A, Matthews, Katherine K, Nicholls, John, Smith, Corey and Khanna, Rajiv (2019). Impact of pre-therapy glioblastoma multiforme microenvironment on clinical response to autologous CMV-specific T-cell therapy. Clinical and Translational Immunology, 8 (11) e01088. doi: 10.1002/cti2.1088

Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis

Pender, Michael P., Csurhes, Peter A., Smith, Corey, Douglas, Nanette L., Neller, Michelle A., Matthews, Katherine K., Beagley, Leone, Rehan, Sweera, Crooks, Pauline, Hopkins, Tracey J., Blum, Stefan, Green, Kerryn A., Ioannides, Zara A., Swayne, Andrew, Aftab, Blake T., Hooper, Kaye D., Burrows, Scott R., Thompson, Kate M., Coulthard, Alan and Khanna, Rajiv (2018). Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis. JCI Insight, 3 (22) e124714. doi: 10.1172/jci.insight.124714

Autologous adoptive T-cell therapy for recurrent or drug-resistant cytomegalovirus complications in solid organ transplant patients: a single-arm open-label phase I clinical trial

Smith, Corey, Beagley, Leone, Rehan, Sweera, Neller, Michelle A., Crooks, Pauline, Solomon, Matthew, Holmes-Liew, Chien-Li, Holmes, Mark, McKenzie, Scott, Hopkins, Peter, Campbell, Scott, Francis, Ross, Chambers, Daniel and Khanna, Rajiv (2018). Autologous adoptive T-cell therapy for recurrent or drug-resistant cytomegalovirus complications in solid organ transplant patients: a single-arm open-label phase I clinical trial. Clinical Infectious Diseases, 68 (4), 632-640. doi: 10.1093/cid/ciy549

BK polyomavirus: clinical aspects, immune regulation, and emerging therapies

Ambalathingal, George R., Francis, Ross S., Smyth, Mark J., Smith, Corey and Khanna, Rajiv (2017). BK polyomavirus: clinical aspects, immune regulation, and emerging therapies. Clinical Microbiology Reviews, 30 (2), 503-528. doi: 10.1128/CMR.00074-16

Autophagy and proteasome interconnect to coordinate cross-presentation through MHC class I pathway in B cells

Dasari, Vijayendra, Rehan, Sweera, Tey, Siok-Keen, Smyth, Mark J., Smith, Corey and Khanna, Rajiv (2016). Autophagy and proteasome interconnect to coordinate cross-presentation through MHC class I pathway in B cells. Immunology and Cell Biology, 94 (10), 964-974. doi: 10.1038/icb.2016.59

Coinfection with human cytomegalovirus genetic variants in transplant recipients and its impact on antiviral T cell immune reconstitution

Smith, Corey, Brennan, Rebekah M., Tey, Siok-Keen, Smyth, Mark J., Burrows, Scott R., Miles, John J., Hill, Geoffrey R. and Khanna, Rajiv (2016). Coinfection with human cytomegalovirus genetic variants in transplant recipients and its impact on antiviral T cell immune reconstitution. Journal of Virology, 90 (16), 7497-7507. doi: 10.1128/JVI.00297-16

Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+ T cell recognition

Tullett, Kirsteen M., Leal Rojas, Ingrid M., Minoda, Yoshihito, Tan, Peck S., Zhang, Jian-Guo, Smith, Corey, Khanna, Rajiv, Shortman, Ken, Caminschi, Irina, Lahoud, Mireille H. and Radford, Kristen J. (2016). Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+ T cell recognition. JCI Insight, 1 (7) e87102, e87102. doi: 10.1172/jci.insight.87102

Prophylactic and therapeutic adenoviral vector-based multivirus-specific T-cell immunotherapy for transplant patients

Dasari, Vijayendra, Schuessler, Andrea, Smith, Corey, Wong, Yide, Miles, John J., Smyth, Mark J., Ambalathingal, George, Francis, Ross, Campbell, Scott, Chambers, Daniel and Khanna, Rajiv (2016). Prophylactic and therapeutic adenoviral vector-based multivirus-specific T-cell immunotherapy for transplant patients. Molecular Therapy - Methods and Clinical Development, 3 (16058) 16058, 16058. doi: 10.1038/mtm.2016.58

Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread

Chawla, Sharad, Warren, Timothy A., Wockner, Leesa F., Lambie, Duncan L. J., Brown, Ian S., Martin, Thomas P. C., Khanna, Rajiv, Leggatt, Graham R. and Panizza, Benedict J. (2016). Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread. Cancer Immunology, Immunotherapy, 65 (2), 213-222. doi: 10.1007/s00262-015-1788-z

Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction

Panikkar, Archana, Smith, Corey, Hislop, Andrew, Tellam, Nick, Dasari, Vijayendra, Hogquist, KristinA, Wykes, Michelle, Moss, Denis J, Rickinson, Alan, Balfour, Henry H and Khanna, Rajiv (2015). Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction. Journal of Virology, 89 (17), 9137-9141. doi: 10.1128/JVI.01293-15

Adoptive T-cell immunotherapy for ganciclovir-resistant CMV disease after lung transplantation

Holmes-Liew, Chien-Li, Holmes, Mark, Beagley, Leone, Hopkins, Peter, Chambers, Daniel, Smith, Corey and Khanna, Rajiv (2015). Adoptive T-cell immunotherapy for ganciclovir-resistant CMV disease after lung transplantation. Clinical and Translational Immunology , 4 (3) e35, e35. doi: 10.1038/cti.2015.5

Epstein-Barr virus-specific adoptive immunotherapy for progressive multiple sclerosis

Pender, Michael P., Csurhes, Peter A., Smith, Corey, Beagley, Leone, Hooper, Kaye D., Raj, Meenakshi, Coulthard, Alan, Burrows, Scott R. and Khanna, Rajiv (2014). Epstein-Barr virus-specific adoptive immunotherapy for progressive multiple sclerosis. Multiple Sclerosis Journal, 20 (11), 1541-1544. doi: 10.1177/1352458514521888

Molecular imprint of exposure to naturally occurring genetic variants of human cytomegalovirus on the T cell repertoire

Smith, Corey, Gras, Stephanie, Brennan, Rebekah M., Bird, Nicola L., Valkenburg, Sophie A., Twist, Kelly-Anne, Burrows, Jacqueline M., Miles, John J., Chambers, Daniel, Bell, Scott, Campbell, Scott, Kedzierska, Katherine, Burrows, Scott R., Rossjohn, Jamie and Khanna, Rajiv (2014). Molecular imprint of exposure to naturally occurring genetic variants of human cytomegalovirus on the T cell repertoire. Scientific Reports, 4 (1) 3993, 3993.1-3993.10. doi: 10.1038/srep03993

Epstein-Barr virus-specific adoptive immunotherapy: A new horizon for multiple sclerosis treatment?

Pender, Michael P. and Khanna, Rajiv (2014). Epstein-Barr virus-specific adoptive immunotherapy: A new horizon for multiple sclerosis treatment?. Immunotherapy, 6 (6), 659-661. doi: 10.2217/imt.14.43

Clinical Assessment of Anti-Viral CD8+ T Cell Immune Monitoring Using QuantiFERON-CMV® Assay to Identify High Risk Allogeneic Hematopoietic Stem Cell Transplant Patients with CMV Infection Complications

Tey, Siok-Keen, Kennedy, Glen A., Cromer, Deborah, Davenport, Miles P., Walker, Susan, Jones, Linda I., Crough, Tania, Durrant, Simon T., Morton, James A., Butler, Jason P., Misra, Ashish K., Hill, Geoffrey R. and Khanna, Rajiv (2013). Clinical Assessment of Anti-Viral CD8+ T Cell Immune Monitoring Using QuantiFERON-CMV® Assay to Identify High Risk Allogeneic Hematopoietic Stem Cell Transplant Patients with CMV Infection Complications. PLoS ONE, 8 (10) e74744, e74744. doi: 10.1371/journal.pone.0074744

HLA peptide length preferences control CD8(+) T cell responses

Rist, Melissa J., Theodossis, Alex, Croft, Nathan P., Neller, Michelle A., Welland, Andrew, Chen, Zhenjun, Sullivan, Lucy C., Burrows, Jacqueline M., Miles, John J., Brennan, Rebekah M., Gras, Stephanie, Khanna, Rajiv, Brooks, Andrew G., McCluskey, James, Purcell, Anthony W., Rossjohn, Jamie and Burrows, Scott R. (2013). HLA peptide length preferences control CD8(+) T cell responses. Journal of Immunology, 191 (2), 561-571. doi: 10.4049/jimmunol.1300292

Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8 + T cells

Smith, Corey, Elhassen, Diah, Gras, Stephanie, Wynn, Katherine K., Dasari, Vijayendra, Tellam, Judy, Tey, Siok-Keen, Rehan, Sweera, Liu, Yu Chih, Rossjohn, Jamie, Burrows, Scott R. and Khanna, Rajiv (2012). Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8 + T cells. Blood, 120 (16), 3237-3245. doi: 10.1182/blood-2012-03-420182

CD8+ T-cell recognition of human cytomegalovirus latency-associated determinant pUL138

Tey, Siok-Keen, Goodrum, Felicia and Khanna, Rajiv (2010). CD8+ T-cell recognition of human cytomegalovirus latency-associated determinant pUL138. Journal of General Virology, 91 (8), 2040-2048. doi: 10.1099/vir.0.020982-0

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

Burrows, Scott R., Chen, Zhenjun, Archbold, Julia K., Tynan, Fleur E., Beddoe, Travis, Kjer-Nielsen, Lars, Miles, John J., Khanna, Rajiv, Moss, Denis J., Liu, Yu Chih, Gras, Stephanie, Kostenko, Lyudmila, Brennan, Rebekah M., Clements, Craig S., Brooks, Andrew G., Purcell, AnthonyW., McCluskey, James and Rossjohn, Jamie (2010). Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability. Proceedings of the National Academy of Sciences of USA, 107 (23), 10608-10613. doi: 10.1073/pnas.1004926107

Narrowing of T-cell receptor beta variable repertoire during symptomatic herpesvirus infection in transplant patients

Wynn, Katherine K., Crough, Tania, Campbell, Scott, McNeil, Keith, Galbraith, Andrew, Moss, Denis J., Silins, Sharon L., Bell, Scott and Khanna, Rajiv (2009). Narrowing of T-cell receptor beta variable repertoire during symptomatic herpesvirus infection in transplant patients. Immunology and Cell Biology, 88 (2), 125-135. doi: 10.1038/icb.2009.74

Immunobiology of Human Cytomegalovirus: from Bench to Bedside

Crough, Tania and Khanna, Rajiv (2009). Immunobiology of Human Cytomegalovirus: from Bench to Bedside. Clinical Microbiology Reviews, 22 (1), 76-98. doi: 10.1128/CMR.00034-08

Epstein-Barr Virus Associated modulation of Wnt pathway is not dependent on latent membrane Protein-1

Webb, Natasha, Connolly, Geoff, Tellman, Judy, Yap, Alpha S. and Khanna, Rajiv (2008). Epstein-Barr Virus Associated modulation of Wnt pathway is not dependent on latent membrane Protein-1. PLoS One, 3 (9) e3254, e3254.1-e3254.8. doi: 10.1371/journal.pone.0003254

Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection

Wynn, K. K., Fulton, Z., Cooper, L., Silins, S., Gras, S., Archbold, J., Tynan, F., Miles, J. J., McCluskey, J., Burrows, S. R., Rossjohn, J. and Khanna, R. (2008). Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection. Blood, 111 (8), 4283-4292. doi: 10.1182/blood-2007-11-122622

CD4+ T cells specific for glycoprotein B from cytomegalovirus exhibit extreme conservation of T-cell receptor usage between different individuals

Crompton, Laura, Khan, Naeem, Khanna, Rajiv, Nayak, Laxman and Moss, Paul A. H. (2008). CD4+ T cells specific for glycoprotein B from cytomegalovirus exhibit extreme conservation of T-cell receptor usage between different individuals. Blood, 111 (4), 2053-2061. doi: 10.1182/blood-2007-04-079863

Symptomatic and asymptomatic viral recrudescence in solid-organ transplant recipients and its relationship with the antigen-specific CD8+ T-cell response

Crough, Tania, Fazou, Chrysa, Weiss, Julissa, Campbell, Scott, Davenport, Miles P., Bell, Scott C., Galbraith, Andrew, McNeil, Keith and Khanna, Rajiv (2007). Symptomatic and asymptomatic viral recrudescence in solid-organ transplant recipients and its relationship with the antigen-specific CD8+ T-cell response. Journal of Virology, 81 (20), 11538-11542. doi: 10.1128/JVI.00581-07

Vaccine strategies against human cytomegalovirus infection

Zhong, Jie and Khanna, Rajiv (2007). Vaccine strategies against human cytomegalovirus infection. Expert Review of Anti-infective Therapy, 5 (3), 449-459. doi: 10.1586/14787210.5.3.449

Influence of translation efficiency of homologous viral proteins on the endogenous presentation of CD8+ T cell epitopes

Tellam, Judy, Fogg, Mark H., Rist, Michael, Connolly, Geoff, Tscharke, David, Webb, Natasha, Heslop, Lea, Wang, Fred and Khanna, Rajiv (2007). Influence of translation efficiency of homologous viral proteins on the endogenous presentation of CD8+ T cell epitopes. Journal of Experimental Medicine, 204 (3), 525-532. doi: 10.1084/jem.20062508

Galectin-1 mediated suppression of Epstein-Barr virus-specific T-cell immunity in classic Hodgkin lymphoma

Gandhi, Maher K., Moll, Guido, Smith, Corey, Dua, Ujjwal, Lambley, Eleanore, Ramuz, Olivier, Gill, Devinder, Marlton, Paula, Seymour, John F. and Khanna, Rajiv (2007). Galectin-1 mediated suppression of Epstein-Barr virus-specific T-cell immunity in classic Hodgkin lymphoma. Blood, 110 (4), 1326-1329. doi: 10.1182/blood-2007-01-066100

Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8(+) T-cell function in Hodgkin lymphoma patients

Gandhi, M. K., Lambley, E., Duraiswamy, J., Dua, U., Smith, C., Elliott, S., Gill, D., Marlton, P., Seymour, J. and Khanna, R. (2006). Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8(+) T-cell function in Hodgkin lymphoma patients. Blood, 108 (7), 2280-2289. doi: 10.1182/blood-2006-04-015164

Human cytomegalovirus vaccine: time to look for alternative options

Khanna, Rajiv and Diamond, Don J. (2006). Human cytomegalovirus vaccine: time to look for alternative options. Trends In Molecular Medicine, 12 (1), 26-33. doi: 10.1016/j.molmed.2005.11.006

Plasma Epstein-Barr virus (EBV) DNA is a biomarker for EBV-positive Hodgkin's lymphoma

Gandhi, M. K., Lambley, E., Burrows, J., Dua, U., Elliott, S., Shaw, P. J., Prince, H. M., Wolf, M., Clarke, K., Underhill, C., Mills, T., Mollee, P., Gill, D., Marlton, P., Seymour, J. F. and Khanna, R. (2006). Plasma Epstein-Barr virus (EBV) DNA is a biomarker for EBV-positive Hodgkin's lymphoma. Clinical Cancer Research, 12 (2), 460-464. doi: 10.1158/1078-0432.CCR-05-2008

Transduction of primary lymphocytes with Epstein-Barr virus (EBV) latent membrane protein-specific T-cell receptor induces lysis of virus-infected cells: A novel strategy for the treatment of Hodgkin's disease and nasopharyngeal carcinoma

Jurgens, Lisa A., Khanna, Rajiv, Weber, James and Orentas, Rimas J. (2006). Transduction of primary lymphocytes with Epstein-Barr virus (EBV) latent membrane protein-specific T-cell receptor induces lysis of virus-infected cells: A novel strategy for the treatment of Hodgkin's disease and nasopharyngeal carcinoma. Journal of Clinical Immunology, 26 (1), 22-32. doi: 10.1007/s10875-006-6532-1

Cross-recognition of human alloantigen by cytomegalovirus glycoprotein-specific CD4+ cytotoxic T lymphocytes: Implications for graft-versus-host disease

Elkington, Rebecca and Khanna, Rajiv (2005). Cross-recognition of human alloantigen by cytomegalovirus glycoprotein-specific CD4+ cytotoxic T lymphocytes: Implications for graft-versus-host disease. Blood, 105 (3), 1362-1364. doi: 10.1182/blood-2004-07-2602

Contemporaneous fluctuations in T cell responses to persistent herpes virus infections

Crough, T, Burrows, JM, Fazou, C, Walker, S, Davenport, MP and Khanna, R (2005). Contemporaneous fluctuations in T cell responses to persistent herpes virus infections. European Journal of Immunology, 35 (1), 139-149. doi: 10.1002/eji.200425548

Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments

Gandhi, Maher K. and Khanna, Rajiv (2004). Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments. Lancet Infectious Diseases, 4 (12), 725-738. doi: 10.1016/S1473-3099(04)01202-2

Selection pressure-driven evolution of the Epstein-Barr virus-encoded oncogene LMP1 in virus isolates from southeast Asia

Burrows, Jacqueline M., Bromham, Lindell, Woolfit, Megan, Piganeau, Gwenael, Tellam, Judy, Connolly, Geoff, Webb, Natasha, Poulsen, Leith, Cooper, Leanne, Burrows, Scott R., Moss, Denis J., Haryana, Sofia M., Ng, Mun, Nicholls, John M. and Khanna, Rajiv (2004). Selection pressure-driven evolution of the Epstein-Barr virus-encoded oncogene LMP1 in virus isolates from southeast Asia. Journal of Virology, 78 (13), 7131-7137. doi: 10.1128/JVI.78.13.7131-7137.2004

Induction of Therapeutic T-Cell Responses to Subdominant Tumor-associated Viral Oncogene after Immunization with Replication-incompetent Polyepitope Adenovirus Vaccine

Duraiswamy, Jaikumar, Bharadwaj, Mandvi, Tellam, Judy, Connolly, Geoff, Cooper, Leanne, Moss, Denis, Thomson, Scott, Yotnda, Patricia and Khanna, Rajiv (2004). Induction of Therapeutic T-Cell Responses to Subdominant Tumor-associated Viral Oncogene after Immunization with Replication-incompetent Polyepitope Adenovirus Vaccine. Cancer Research, 64 (4), 1483-1489. doi: 10.1158/0008-5472.CAN-03-2196

Cross-reactive recognition of human and primate cytomegalovirus sequences by human CD4 cytotoxic T lymphocytes specific for glycoprotein B and H

Elkington, Rebecca, Shoukry, Naglaa H., Walker, Susan, Crough, Tania, Fazou, Chrysa, Kaur, Amitinder, Walker, Christopher M. and Khanna, Rajiv (2004). Cross-reactive recognition of human and primate cytomegalovirus sequences by human CD4 cytotoxic T lymphocytes specific for glycoprotein B and H. European Journal of Immunology, 34 (11), 3216-3226. doi: 10.1002/eji.200425203

Determining virological, serological and immunological parameters of EBV infection in the development of PTLD

Davis, J. E., Sherritt, M. A., Bharadwaj, M., Morrison, L. E., Elliott, S. L., Kear, L. M., Maddicks-Law, J., Kotsimbos, T., Gill, D., Malouf, M., Falk, M. C., Khanna, R. and Moss, D. J. (2004). Determining virological, serological and immunological parameters of EBV infection in the development of PTLD. International Immunology, 16 (7), 983-989. doi: 10.1093/intimm/dxh099

Endogenous Presentation of CD8+ T Cell Epitopes from Epstein-Barr Virus–encoded Nuclear Antigen 1

Tellam, J., Connolly, G., Green, K. J., Miles, J. J., Moss, D. J., Burrows, S. R. and Khanna, R. (2004). Endogenous Presentation of CD8+ T Cell Epitopes from Epstein-Barr Virus–encoded Nuclear Antigen 1. Journal of Experimental Medicine, 199 (10), 1421-1431. doi: 10.1084/jem.20040191

Epstein-Barr virus-associated Hodgkin's lymphoma

Gandhi, Maher K., Tellam, Judy T. and Khanna, Rajiv (2004). Epstein-Barr virus-associated Hodgkin's lymphoma. British Journal of Haematology, 125 (3), 267-281. doi: 10.1111/j.1365-2141.2004.04902.x

Herpesvirus-specific CD8 T cell immunity in old age: Cytomegalovirus impairs the response to a coresident EBV infection

Khan, N, Hislop, A, Gudgeon, N, Cobbold, M, Khanna, R, Nayak, L, Rickinson, AB and Moss, PAH (2004). Herpesvirus-specific CD8 T cell immunity in old age: Cytomegalovirus impairs the response to a coresident EBV infection. Journal of Immunology, 173 (12), 7481-7489.

Predictive algorithms and T cell epitope mapping

Khanna, R (2004). Predictive algorithms and T cell epitope mapping. Journal of Immunology, 173 (5), 2895-2896. doi: 10.4049/jimmunol.173.5.2895

Ex vivo analysis of T-cell responses to Epstein-Barr virus-encoded oncogene latent membrane protein 1 reveals highly conserved epitope sequences in virus isolates from diverse geographic regions

Duraiswamy, Jaikumar, Burrows, Jacqueline M., Bharadwaj, Mandvi, Burrows, Scott R., Cooper, Leanne, Pimtanothai, Nattiya and Khanna, Rajiv (2003). Ex vivo analysis of T-cell responses to Epstein-Barr virus-encoded oncogene latent membrane protein 1 reveals highly conserved epitope sequences in virus isolates from diverse geographic regions. Journal of Virology, 77 (13), 7401-7410. doi: 10.1128/JVI.77.13.7401-7410.2003

Ex vivo profiling of CD8(+)-T-cell responses to human cytomegalovirus reveals broad and multispecific reactivities in healthy virus carriers

Elkington, Rebecca, Walker, Susan, Crough, Tania, Menzies, Moira, Tellam, Judy, Bharadwaj, Mandvi and Khanna, Rajiv (2003). Ex vivo profiling of CD8(+)-T-cell responses to human cytomegalovirus reveals broad and multispecific reactivities in healthy virus carriers. Journal of Virology, 77 (9), 5226-5240. doi: 10.1128/JVI.77.9.5226-5240.2003

Reconstitution of the latent T-lymphocyte response to Epstein-Barr virus is coincident with long-term recovery from post-transplant lymphoma after adoptive immunotherapy

Sherritt, M. A., Bharadwaj, M., Burrows, J. M., Morrison, L. E., Elliott, S. L., Davis, J. E., Kear, L. M., Slaughter, R. E., Bell, S. C., Galbraith, A. J., Khanna, R. and Moss, D. J. (2003). Reconstitution of the latent T-lymphocyte response to Epstein-Barr virus is coincident with long-term recovery from post-transplant lymphoma after adoptive immunotherapy. Transplantation, 75 (9), 1556-1560. doi: 10.1097/01.TP.0000058745.02123.6F

Promiscuous CTL recognition of viral epitopes on multiple human leukocyte antigens: Biological validation of the proposed HLA A24 supertype

Burrows, S. R., Elkington, R. A., Miles, J. J., Green, K. J., Walker, S., Haryana, S. M., Moss, D. J., Dunckley, H., Burrows, J. M. and Khanna, R. (2003). Promiscuous CTL recognition of viral epitopes on multiple human leukocyte antigens: Biological validation of the proposed HLA A24 supertype. Journal of Immunology, 171 (3), 1407-1412. doi: 10.4049/jimmunol.171.3.1407

Proteasomal targeting of a viral oncogene abrogates oncogenic phenotype and enhances immunogenicity

Tellam, J, Connolly, G, Webb, N, Duraiswamy, J and Khanna, R (2003). Proteasomal targeting of a viral oncogene abrogates oncogenic phenotype and enhances immunogenicity. Blood, 102 (13), 4535-4540. doi: 10.1182/blood-2003-03-0870

Therapeutic LMP1 polyepitope vaccine for EBV-assolciated Hodgkin disease and nasopharyngeal carcinoma

Duraiswamy, Jaikumar, Sherritt, Martina, Thomson, Scott, Tellam, Judy, Cooper, Leanne, Connolly, Geoff, Bharadwaj, Mandvi and Khanna, Rajiv (2003). Therapeutic LMP1 polyepitope vaccine for EBV-assolciated Hodgkin disease and nasopharyngeal carcinoma. Blood, 101 (8), 3150-3156. doi: 10.1182/blood-2002-10-3092

RelB nuclear translocation mediated by C-terminal activator reigons of Epstein Barr virus-encoded latent membrane protein 1 and its effect on antigen-presenting function in B cells

Pai, Saparna, O'Sullivan, Brendan J., Cooper, Leanne, Thomas, Ranjeny and Khanna, Rajiv (2002). RelB nuclear translocation mediated by C-terminal activator reigons of Epstein Barr virus-encoded latent membrane protein 1 and its effect on antigen-presenting function in B cells. Journal of Virology, 76 (4), 1914-1921. doi: 10.1128/JVI.76.4.1914-1921.2002

Will a vaccine to nasopharyngeal carcinoma retain orphan status?

Moss, D. J., Khanna, R. and Bharadwaj, M. (2002). Will a vaccine to nasopharyngeal carcinoma retain orphan status?. Developments in Biologicals, 116, 252-256.

Targeting of EBNA1 for rapid intracellular degradation overrides the inhibitory effects of the Gly-Ala repeat domain and restores CD8+T cell recognition

Tellam, Judy, Sherritt, Martina, Thomson, Scott, Tellam, Ross, Moss, Denis J., Burrows, Scott R., Wiertz, Emmanuel and Khanna, Rajiv (2001). Targeting of EBNA1 for rapid intracellular degradation overrides the inhibitory effects of the Gly-Ala repeat domain and restores CD8+T cell recognition. Journal of Biological Chemistry, 276 (36), 33353-33360. doi: 10.1074/jbc.M104535200

Contrasting Epstein-Barr virus-specific cytotoxic T cell responses to HLA A2-restricted epitopes in humans and HLA transgenic mice: implications for vaccine design

Sherritt, M., Bharadwaj, M., Khanna, R. and Moss, D. J. (2001). Contrasting Epstein-Barr virus-specific cytotoxic T cell responses to HLA A2-restricted epitopes in humans and HLA transgenic mice: implications for vaccine design. Vaccine, 19 (27), 3769-3777. doi: 10.1016/S0264-410X(01)00085-8

Immunotherapeutic strategies for EBV-associated malignancies

Khanna, R., Tellam, J., Duraiswamy, J. and Cooper, L. (2001). Immunotherapeutic strategies for EBV-associated malignancies. Trends in Molecular Medicine, 76 (6), 270-276. doi: 10.1016/S1471-4914(01)02002-0

Activation and adoptive transfer of Epstein-Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease

Khanna, R., Bell, S., Sherritt, M., Galbraith, A., Burrows, S. R., Rafter, L., Clarke, B., Slaughter, R., Falk, M. C., Douglass, J., Williams, T., Elliott, S. L. and Moss, D. J. (1999). Activation and adoptive transfer of Epstein-Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease. Proceedings of the National Academy of Sciences of the United States of America, 96 (18), 10391-10396. doi: 10.1073/pnas.96.18.10391

Cutting Edge: Silencing virus-specific cytotoxic T cell-mediated immune recognition by differential splicing: A novel implication of RNA processing for antigen presentation

Kienzle, Norbert, Sculley, Tom B., Greco, Sonia and Khanna, Rajiv (1999). Cutting Edge: Silencing virus-specific cytotoxic T cell-mediated immune recognition by differential splicing: A novel implication of RNA processing for antigen presentation. Journal of Immunology, 162 (12), 6963-6966.

Cytotoxic T cell recognition of allelic variants of HLA B35 bound to an Epstein-Barr virus epitope: influence of peptide conformation and TCF-peptide interaction.

Khanna, Rajiv, Silins, Sharon L., Weng, Zhiping, Gatchell, David, Burrows, Scott R. and Cooper, Leanne (1999). Cytotoxic T cell recognition of allelic variants of HLA B35 bound to an Epstein-Barr virus epitope: influence of peptide conformation and TCF-peptide interaction.. European Journal of Immunology, 29 (5), 1587-1597. doi: 10.1002/(SICI)1521-4141(199905)29:05

Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: Implications for molecular mimicry in autoimmune disease

Misko, Ihor S., Cross, Simone M., Khanna, Rajiv, Elliott, Suzanne L., Schmidt, Christopher, Pye, Stephanie J. and Silins, Sharon L. (1999). Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: Implications for molecular mimicry in autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America, 96 (5), 2279-2284. doi: 10.1073/pnas.96.5.2279

EBV structural antigens, gp350 and gp85, as targets for ex vivo virus-specific CTL during acute infectious mononucleosis: Potential use of gp350/gp85 CTL epitopes for vaccine design

Khanna, Rajiv, Sherritt, Martina and Burrows, Scott R. (1999). EBV structural antigens, gp350 and gp85, as targets for ex vivo virus-specific CTL during acute infectious mononucleosis: Potential use of gp350/gp85 CTL epitopes for vaccine design. Journal of Immunology, 162 (5), 3063-3069.

Direct alloreactivity by human cytotoxic T lymphocytes can be inhibited by altered peptide ligand antagonism

Burrows, Scott R., Khanna, Rajiv and Moss, Denis J. (1999). Direct alloreactivity by human cytotoxic T lymphocytes can be inhibited by altered peptide ligand antagonism. Blood, 93 (3), 1020-1024. doi: 10.1182/blood.v93.3.1020

X-linked agammaglobulinemia patients are not infected with Epstein-Barr virus: Implications for the biology of the virus

Faulkner, Glenda C., Burrows, Scott R., Khanna, Rajiv, Moss, Denis J., Bird, A. Graham and Crawford, Dorothy H. (1999). X-linked agammaglobulinemia patients are not infected with Epstein-Barr virus: Implications for the biology of the virus. Journal of Virology, 73 (2), 1555-1564.

Developing immunotherapeutic strategies for the control of Epstein-Barr virus-associated malignancies.

Moss, D., Khanna, R., Sherritt, M., Elliott, S. L. and Burrows, S. R. (1999). Developing immunotherapeutic strategies for the control of Epstein-Barr virus-associated malignancies.. Journal of acquired immune deficiency syndromes and human retrovirology, 21, S80-S83.

Immune control of EBV-associated diseases and its implication for vaccine design.

Khanna, R., Moss, D. J. and Burrows, S. R. (1999). Immune control of EBV-associated diseases and its implication for vaccine design.. Immunological Reviews, 70, 49-64.

The influence of anti-viral T cell responses on the alloreactive repertoire

Burrows, S. R., Khanna, R., Silins, S. L. and Moss, D. (1999). The influence of anti-viral T cell responses on the alloreactive repertoire. Immunology Today, 20 (5), 203-207. doi: 10.1016/S0167-5699(98)01429-7

Vaccine strategies against Epstein-Barr virus-associated diseases: lessons from studies on cytotoxic T-cell-mediated immune regulation.

Khanna, R., Moss, D. and Burrows, S. R. (1999). Vaccine strategies against Epstein-Barr virus-associated diseases: lessons from studies on cytotoxic T-cell-mediated immune regulation.. Immunological Reviews, 170 (1), 49-64. doi: 10.1111/j.1600-065X.1999.tb01328.x

Constitutive transduction of peptide transporter and HLA genes restores antigen processing function and cytotoxic T cell-mediated immune recognition of human melanoma cells

White, C. A., Thomson, S. A., Cooper, L., van Endert, P. M., Tampe, R., Coupar, B., Qiu, L., Parsons, P. G., Moss, D. J. and Khanna, R. (1998). Constitutive transduction of peptide transporter and HLA genes restores antigen processing function and cytotoxic T cell-mediated immune recognition of human melanoma cells. International Journal of Cancer, 75 (4), 590-595. doi: 10.1002/(SICI)1097-0215(19980209)75:4<590::AID-IJC16>3.0.CO;2-D

Will a vaccine to nasopharyngeal carcinoma retain orphan status?

Moss, D. J., Khanna, R. and Bharadwaj, M. (2002). Will a vaccine to nasopharyngeal carcinoma retain orphan status?. Orphan vaccines - Bridging the gap, Palm Cove, Queensland, 25-29 Aug, 2001. Basel: Karger.