Journal Article: Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis
Pender, Michael P., Csurhes, Peter A., Smith, Corey, Douglas, Nanette L., Neller, Michelle A., Matthews, Katherine K., Beagley, Leone, Rehan, Sweera, Crooks, Pauline, Hopkins, Tracey J., Blum, Stefan, Green, Kerryn A., Ioannides, Zara A., Swayne, Andrew, Aftab, Blake T., Hooper, Kaye D., Burrows, Scott R., Thompson, Kate M., Coulthard, Alan and Khanna, Rajiv (2018) Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis. JCI Insight, 3 22: . doi:10.1172/jci.insight.124714
Smith, Corey, Beagley, Leone, Rehan, Sweera, Neller, Michelle A., Crooks, Pauline, Solomon, Matthew, Holmes-Liew, Chien-Li, Holmes, Mark, McKenzie, Scott, Hopkins, Peter, Campbell, Scott, Francis, Ross, Chambers, Daniel and Khanna, Rajiv (2018) Autologous adoptive T-cell therapy for recurrent or drug-resistant cytomegalovirus complications in solid organ transplant patients: a single-arm open-label phase I clinical trial. Clinical Infectious Diseases, . doi:10.1093/cid/ciy549
Journal Article: BK polyomavirus: clinical aspects, immune regulation, and emerging therapies
Ambalathingal, George R., Francis, Ross S., Smyth, Mark J., Smith, Corey and Khanna, Rajiv (2017) BK polyomavirus: clinical aspects, immune regulation, and emerging therapies. Clinical Microbiology Reviews, 30 2: 503-528. doi:10.1128/CMR.00074-16
Strategies for improving T-cell manufacturing for adoptive immunotherapies
Doctor Philosophy
Developing antibody-based therapy to treat acute Epstein-Barr virus infection and prevent its associated diseases
Doctor Philosophy
T cell-mediated immune regulation of BK Virus
(2018) Doctor Philosophy
Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis
Pender, Michael P., Csurhes, Peter A., Smith, Corey, Douglas, Nanette L., Neller, Michelle A., Matthews, Katherine K., Beagley, Leone, Rehan, Sweera, Crooks, Pauline, Hopkins, Tracey J., Blum, Stefan, Green, Kerryn A., Ioannides, Zara A., Swayne, Andrew, Aftab, Blake T., Hooper, Kaye D., Burrows, Scott R., Thompson, Kate M., Coulthard, Alan and Khanna, Rajiv (2018) Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis. JCI Insight, 3 22: . doi:10.1172/jci.insight.124714
Smith, Corey, Beagley, Leone, Rehan, Sweera, Neller, Michelle A., Crooks, Pauline, Solomon, Matthew, Holmes-Liew, Chien-Li, Holmes, Mark, McKenzie, Scott, Hopkins, Peter, Campbell, Scott, Francis, Ross, Chambers, Daniel and Khanna, Rajiv (2018) Autologous adoptive T-cell therapy for recurrent or drug-resistant cytomegalovirus complications in solid organ transplant patients: a single-arm open-label phase I clinical trial. Clinical Infectious Diseases, . doi:10.1093/cid/ciy549
BK polyomavirus: clinical aspects, immune regulation, and emerging therapies
Ambalathingal, George R., Francis, Ross S., Smyth, Mark J., Smith, Corey and Khanna, Rajiv (2017) BK polyomavirus: clinical aspects, immune regulation, and emerging therapies. Clinical Microbiology Reviews, 30 2: 503-528. doi:10.1128/CMR.00074-16
Smith, Corey, Brennan, Rebekah M., Tey, Siok-Keen, Smyth, Mark J., Burrows, Scott R., Miles, John J., Hill, Geoffrey R. and Khanna, Rajiv (2016) Coinfection with human cytomegalovirus genetic variants in transplant recipients and its impact on antiviral T cell immune reconstitution. Journal of Virology, 90 16: 7497-7507. doi:10.1128/JVI.00297-16
Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+ T cell recognition
Tullett, Kirsteen M., Leal Rojas, Ingrid M., Minoda, Yoshihito, Tan, Peck S., Zhang, Jian-Guo, Smith, Corey, Khanna, Rajiv, Shortman, Ken, Caminschi, Irina, Lahoud, Mireille H. and Radford, Kristen J. (2016) Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+ T cell recognition. JCI Insight, 1 7: . doi:10.1172/jci.insight.87102
Dasari, Vijayendra, Schuessler, Andrea, Smith, Corey, Wong, Yide, Miles, John J., Smyth, Mark J., Ambalathingal, George, Francis, Ross, Campbell, Scott, Chambers, Daniel and Khanna, Rajiv (2016) Prophylactic and therapeutic adenoviral vector-based multivirus-specific T-cell immunotherapy for transplant patients. Molecular Therapy - Methods and Clinical Development, 3 16058: 16058. doi:10.1038/mtm.2016.58
Chawla, Sharad, Warren, Timothy A., Wockner, Leesa F., Lambie, Duncan L. J., Brown, Ian S., Martin, Thomas P. C., Khanna, Rajiv, Leggatt, Graham R. and Panizza, Benedict J. (2016) Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread. Cancer Immunology, Immunotherapy, 65 2: 213-222. doi:10.1007/s00262-015-1788-z
Panikkar, Archana, Smith, Corey, Hislop, Andrew, Tellam, Nick, Dasari, Vijayendra, Hogquist, KristinA, Wykes, Michelle, Moss, Denis J, Rickinson, Alan, Balfour, Henry H and Khanna, Rajiv (2015) Impaired Epstein-Barr virus-specific neutralizing antibody response during acute infectious mononucleosis is coincident with global B-cell dysfunction. Journal of Virology, 89 17: 9137-9141. doi:10.1128/JVI.01293-15
Adoptive T-cell immunotherapy for ganciclovir-resistant CMV disease after lung transplantation
Holmes-Liew, Chien-Li, Holmes, Mark, Beagley, Leone, Hopkins, Peter, Chambers, Daniel, Smith, Corey and Khanna, Rajiv (2015) Adoptive T-cell immunotherapy for ganciclovir-resistant CMV disease after lung transplantation. Clinical and Translational Immunology , 4 3: e35. doi:10.1038/cti.2015.5
Epstein-Barr virus-specific adoptive immunotherapy for progressive multiple sclerosis
Pender, Michael P., Csurhes, Peter A., Smith, Corey, Beagley, Leone, Hooper, Kaye D., Raj, Meenakshi, Coulthard, Alan, Burrows, Scott R. and Khanna, Rajiv (2014) Epstein-Barr virus-specific adoptive immunotherapy for progressive multiple sclerosis. Multiple Sclerosis Journal, 20 11: 1541-1544. doi:10.1177/1352458514521888
Smith, Corey, Gras, Stephanie, Brennan, Rebekah M., Bird, Nicola L., Valkenburg, Sophie A., Twist, Kelly-Anne, Burrows, Jacqueline M., Miles, John J., Chambers, Daniel, Bell, Scott, Campbell, Scott, Kedzierska, Katherine, Burrows, Scott R., Rossjohn, Jamie and Khanna, Rajiv (2014) Molecular imprint of exposure to naturally occurring genetic variants of human cytomegalovirus on the T cell repertoire. Scientific Reports, 4 3993.1-3993.10. doi:10.1038/srep03993
Epstein-Barr virus-specific adoptive immunotherapy: A new horizon for multiple sclerosis treatment?
Pender, Michael P. and Khanna, Rajiv (2014) Epstein-Barr virus-specific adoptive immunotherapy: A new horizon for multiple sclerosis treatment?. Immunotherapy, 6 6: 659-661. doi:10.2217/imt.14.43
Tey, Siok-Keen, Kennedy, Glen A., Cromer, Deborah, Davenport, Miles P., Walker, Susan, Jones, Linda I., Crough, Tania, Durrant, Simon T., Morton, James A., Butler, Jason P., Misra, Ashish K., Hill, Geoffrey R. and Khanna, Rajiv (2013) Clinical Assessment of Anti-Viral CD8+ T Cell Immune Monitoring Using QuantiFERON-CMV® Assay to Identify High Risk Allogeneic Hematopoietic Stem Cell Transplant Patients with CMV Infection Complications. PLoS ONE, 8 10: . doi:10.1371/journal.pone.0074744
HLA peptide length preferences control CD8(+) T cell responses
Rist, Melissa J., Theodossis, Alex, Croft, Nathan P., Neller, Michelle A., Welland, Andrew, Chen, Zhenjun, Sullivan, Lucy C., Burrows, Jacqueline M., Miles, John J., Brennan, Rebekah M., Gras, Stephanie, Khanna, Rajiv, Brooks, Andrew G., McCluskey, James, Purcell, Anthony W., Rossjohn, Jamie and Burrows, Scott R. (2013) HLA peptide length preferences control CD8(+) T cell responses. Journal of Immunology, 191 2: 561-571. doi:10.4049/jimmunol.1300292
Smith, Corey, Elhassen, Diah, Gras, Stephanie, Wynn, Katherine K., Dasari, Vijayendra, Tellam, Judy, Tey, Siok-Keen, Rehan, Sweera, Liu, Yu Chih, Rossjohn, Jamie, Burrows, Scott R. and Khanna, Rajiv (2012) Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8 + T cells. Blood, 120 16: 3237-3245. doi:10.1182/blood-2012-03-420182
CD8+ T-cell recognition of human cytomegalovirus latency-associated determinant pUL138
Tey, Siok-Keen, Goodrum, Felicia and Khanna, Rajiv (2010) CD8+ T-cell recognition of human cytomegalovirus latency-associated determinant pUL138. Journal of General Virology, 91 8: 2040-2048. doi:10.1099/vir.0.020982-0
Burrows, Scott R., Chen, Zhenjun, Archbold, Julia K., Tynan, Fleur E., Beddoe, Travis, Kjer-Nielsen, Lars, Miles, John J., Khanna, Rajiv, Moss, Denis J., Liu, Yu Chih, Gras, Stephanie, Kostenko, Lyudmila, Brennan, Rebekah M., Clements, Craig S., Brooks, Andrew G., Purcell, AnthonyW., McCluskey, James and Rossjohn, Jamie (2010) Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability. Proceedings of the National Academy of Sciences of USA, 107 23: 10608-10613. doi:10.1073/pnas.1004926107
Wynn, Katherine K., Crough, Tania, Campbell, Scott, McNeil, Keith, Galbraith, Andrew, Moss, Denis J., Silins, Sharon L., Bell, Scott and Khanna, Rajiv (2009) Narrowing of T-cell receptor beta variable repertoire during symptomatic herpesvirus infection in transplant patients. Immunology and Cell Biology, 88 2: 125-135. doi:10.1038/icb.2009.74
Immunobiology of Human Cytomegalovirus: from Bench to Bedside
Crough, Tania and Khanna, Rajiv (2009) Immunobiology of Human Cytomegalovirus: from Bench to Bedside. Clinical Microbiology Reviews, 22 1: 76-98. doi:10.1128/CMR.00034-08
Webb, Natasha, Connolly, Geoff, Tellman, Judy, Yap, Alpha S. and Khanna, Rajiv (2008) Epstein-Barr Virus Associated modulation of Wnt pathway is not dependent on latent membrane Protein-1. PLoS One, 3 9: e3254.1-e3254.8. doi:10.1371/journal.pone.0003254
Wynn, K. K., Fulton, Z., Cooper, L., Silins, S., Gras, S., Archbold, J., Tynan, F., Miles, J. J., McCluskey, J., Burrows, S. R., Rossjohn, J. and Khanna, R. (2008) Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection. Blood, 111 8: 4283-4292. doi:10.1182/blood-2007-11-122622
Crompton, Laura, Khan, Naeem, Khanna, Rajiv, Nayak, Laxman and Moss, Paul A. H. (2008) CD4+ T cells specific for glycoprotein B from cytomegalovirus exhibit extreme conservation of T-cell receptor usage between different individuals. Blood, 111 4: 2053-2061. doi:10.1182/blood-2007-04-079863
Crough, Tania, Fazou, Chrysa, Weiss, Julissa, Campbell, Scott, Davenport, Miles P., Bell, Scott C., Galbraith, Andrew, McNeil, Keith and Khanna, Rajiv (2007) Symptomatic and asymptomatic viral recrudescence in solid-organ transplant recipients and its relationship with the antigen-specific CD8+ T-cell response. Journal of Virology, 81 20: 11538-11542. doi:10.1128/JVI.00581-07
Vaccine strategies against human cytomegalovirus infection
Zhong, Jie and Khanna, Rajiv (2007) Vaccine strategies against human cytomegalovirus infection. Expert Review of Anti-infective Therapy, 5 3: 449-459. doi:10.1586/14787210.5.3.449
Tellam, Judy, Fogg, Mark H., Rist, Michael, Connolly, Geoff, Tscharke, David, Webb, Natasha, Heslop, Lea, Wang, Fred and Khanna, Rajiv (2007) Influence of translation efficiency of homologous viral proteins on the endogenous presentation of CD8+ T cell epitopes. Journal of Experimental Medicine, 204 3: 525-532. doi:10.1084/jem.20062508
Gandhi, Maher K., Moll, Guido, Smith, Corey, Dua, Ujjwal, Lambley, Eleanore, Ramuz, Olivier, Gill, Devinder, Marlton, Paula, Seymour, John F. and Khanna, Rajiv (2007) Galectin-1 mediated suppression of Epstein-Barr virus-specific T-cell immunity in classic Hodgkin lymphoma. Blood, 110 4: 1326-1329. doi:10.1182/blood-2007-01-066100
Gandhi, M. K., Lambley, E., Duraiswamy, J., Dua, U., Smith, C., Elliott, S., Gill, D., Marlton, P., Seymour, J. and Khanna, R. (2006) Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8(+) T-cell function in Hodgkin lymphoma patients. Blood, 108 7: 2280-2289. doi:10.1182/blood-2006-04-015164
Human cytomegalovirus vaccine: time to look for alternative options
Khanna, Rajiv and Diamond, Don J. (2006) Human cytomegalovirus vaccine: time to look for alternative options. Trends In Molecular Medicine, 12 1: 26-33. doi:10.1016/j.molmed.2005.11.006
Plasma Epstein-Barr virus (EBV) DNA is a biomarker for EBV-positive Hodgkin's lymphoma
Gandhi, M. K., Lambley, E., Burrows, J., Dua, U., Elliott, S., Shaw, P. J., Prince, H. M., Wolf, M., Clarke, K., Underhill, C., Mills, T., Mollee, P., Gill, D., Marlton, P., Seymour, J. F. and Khanna, R. (2006) Plasma Epstein-Barr virus (EBV) DNA is a biomarker for EBV-positive Hodgkin's lymphoma. Clinical Cancer Research, 12 2: 460-464. doi:10.1158/1078-0432.CCR-05-2008
Jurgens, Lisa A., Khanna, Rajiv, Weber, James and Orentas, Rimas J. (2006) Transduction of primary lymphocytes with Epstein-Barr virus (EBV) latent membrane protein-specific T-cell receptor induces lysis of virus-infected cells: A novel strategy for the treatment of Hodgkin's disease and nasopharyngeal carcinoma. Journal of Clinical Immunology, 26 1: 22-32. doi:10.1007/s10875-006-6532-1
Elkington, Rebecca and Khanna, Rajiv (2005) Cross-recognition of human alloantigen by cytomegalovirus glycoprotein-specific CD4+ cytotoxic T lymphocytes: Implications for graft-versus-host disease. Blood, 105 3: 1362-1364. doi:10.1182/blood-2004-07-2602
Contemporaneous fluctuations in T cell responses to persistent herpes virus infections
Crough, T, Burrows, JM, Fazou, C, Walker, S, Davenport, MP and Khanna, R (2005) Contemporaneous fluctuations in T cell responses to persistent herpes virus infections. European Journal of Immunology, 35 1: 139-149. doi:10.1002/eji.200425548
Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments
Gandhi, Maher K. and Khanna, Rajiv (2004) Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments. Lancet Infectious Diseases, 4 12: 725-738. doi:10.1016/S1473-3099(04)01202-2
Burrows, Jacqueline M., Bromham, Lindell, Woolfit, Megan, Piganeau, Gwenael, Tellam, Judy, Connolly, Geoff, Webb, Natasha, Poulsen, Leith, Cooper, Leanne, Burrows, Scott R., Moss, Denis J., Haryana, Sofia M., Ng, Mun, Nicholls, John M. and Khanna, Rajiv (2004) Selection pressure-driven evolution of the Epstein-Barr virus-encoded oncogene LMP1 in virus isolates from southeast Asia. Journal of Virology, 78 13: 7131-7137. doi:10.1128/JVI.78.13.7131-7137.2004
Duraiswamy, Jaikumar, Bharadwaj, Mandvi, Tellam, Judy, Connolly, Geoff, Cooper, Leanne, Moss, Denis, Thomson, Scott, Yotnda, Patricia and Khanna, Rajiv (2004) Induction of Therapeutic T-Cell Responses to Subdominant Tumor-associated Viral Oncogene after Immunization with Replication-incompetent Polyepitope Adenovirus Vaccine. Cancer Research, 64 4: 1483-1489. doi:10.1158/0008-5472.CAN-03-2196
Elkington, Rebecca, Shoukry, Naglaa H., Walker, Susan, Crough, Tania, Fazou, Chrysa, Kaur, Amitinder, Walker, Christopher M. and Khanna, Rajiv (2004) Cross-reactive recognition of human and primate cytomegalovirus sequences by human CD4 cytotoxic T lymphocytes specific for glycoprotein B and H. European Journal of Immunology, 34 11: 3216-3226. doi:10.1002/eji.200425203
Davis, J. E., Sherritt, M. A., Bharadwaj, M., Morrison, L. E., Elliott, S. L., Kear, L. M., Maddicks-Law, J., Kotsimbos, T., Gill, D., Malouf, M., Falk, M. C., Khanna, R. and Moss, D. J. (2004) Determining virological, serological and immunological parameters of EBV infection in the development of PTLD. International Immunology, 16 7: 983-989. doi:10.1093/intimm/dxh099
Endogenous Presentation of CD8+ T Cell Epitopes from Epstein-Barr Virus–encoded Nuclear Antigen 1
Tellam, J., Connolly, G., Green, K. J., Miles, J. J., Moss, D. J., Burrows, S. R. and Khanna, R. (2004) Endogenous Presentation of CD8+ T Cell Epitopes from Epstein-Barr Virus–encoded Nuclear Antigen 1. Journal of Experimental Medicine, 199 10: 1421-1431. doi:10.1084/jem.20040191
Epstein-Barr virus-associated Hodgkin's lymphoma
Gandhi, Maher K., Tellam, Judy T. and Khanna, Rajiv (2004) Epstein-Barr virus-associated Hodgkin's lymphoma. British Journal of Haematology, 125 3: 267-281. doi:10.1111/j.1365-2141.2004.04902.x
Khan, N, Hislop, A, Gudgeon, N, Cobbold, M, Khanna, R, Nayak, L, Rickinson, AB and Moss, PAH (2004) Herpesvirus-specific CD8 T cell immunity in old age: Cytomegalovirus impairs the response to a coresident EBV infection. Journal of Immunology, 173 12: 7481-7489.
Predictive algorithms and T cell epitope mapping
Khanna, R (2004) Predictive algorithms and T cell epitope mapping. Journal of Immunology, 173 5: 2895-2896.
Duraiswamy, Jaikumar, Burrows, Jacqueline M., Bharadwaj, Mandvi, Burrows, Scott R., Cooper, Leanne, Pimtanothai, Nattiya and Khanna, Rajiv (2003) Ex vivo analysis of T-cell responses to Epstein-Barr virus-encoded oncogene latent membrane protein 1 reveals highly conserved epitope sequences in virus isolates from diverse geographic regions. Journal of Virology, 77 13: 7401-7410. doi:10.1128/JVI.77.13.7401-7410.2003
Elkington, Rebecca, Walker, Susan, Crough, Tania, Menzies, Moira, Tellam, Judy, Bharadwaj, Mandvi and Khanna, Rajiv (2003) Ex vivo profiling of CD8(+)-T-cell responses to human cytomegalovirus reveals broad and multispecific reactivities in healthy virus carriers. Journal of Virology, 77 9: 5226-5240. doi:10.1128/JVI.77.9.5226-5240.2003
Sherritt, M. A., Bharadwaj, M., Burrows, J. M., Morrison, L. E., Elliott, S. L., Davis, J. E., Kear, L. M., Slaughter, R. E., Bell, S. C., Galbraith, A. J., Khanna, R. and Moss, D. J. (2003) Reconstitution of the latent T-lymphocyte response to Epstein-Barr virus is coincident with long-term recovery from post-transplant lymphoma after adoptive immunotherapy. Transplantation, 75 9: 1556-1560. doi:10.1097/01.TP.0000058745.02123.6F
Burrows, S. R., Elkington, R. A., Miles, J. J., Green, K. J., Walker, S., Haryana, S. M., Moss, D. J., Dunckley, H., Burrows, J. M. and Khanna, R. (2003) Promiscuous CTL recognition of viral epitopes on multiple human leukocyte antigens: Biological validation of the proposed HLA A24 supertype. Journal of Immunology, 171 3: 1407-1412.
Proteasomal targeting of a viral oncogene abrogates oncogenic phenotype and enhances immunogenicity
Tellam, J, Connolly, G, Webb, N, Duraiswamy, J and Khanna, R (2003) Proteasomal targeting of a viral oncogene abrogates oncogenic phenotype and enhances immunogenicity. Blood, 102 13: 4535-4540. doi:10.1182/blood-2003-03-0870
Duraiswamy, Jaikumar, Sherritt, Martina, Thomson, Scott, Tellam, Judy, Cooper, Leanne, Connolly, Geoff, Bharadwaj, Mandvi and Khanna, Rajiv (2003) Therapeutic LMP1 polyepitope vaccine for EBV-assolciated Hodgkin disease and nasopharyngeal carcinoma. Blood, 101 8: 3150-3156. doi:10.1182/blood-2002-10-3092
Pai, Saparna, O'Sullivan, Brendan J., Cooper, Leanne, Thomas, Ranjeny and Khanna, Rajiv (2002) RelB nuclear translocation mediated by C-terminal activator reigons of Epstein Barr virus-encoded latent membrane protein 1 and its effect on antigen-presenting function in B cells. Journal of Virology, 76 4: 1914-1921. doi:10.1128/JVI.76.4.1914-1921.2002
Will a vaccine to nasopharyngeal carcinoma retain orphan status?
Moss, D. J., Khanna, R. and Bharadwaj, M. (2002) Will a vaccine to nasopharyngeal carcinoma retain orphan status?. Developments in Biologicals, 116 252-256.
Tellam, Judy, Sherritt, Martina, Thomson, Scott, Tellam, Ross, Moss, Denis J., Burrows, Scott R., Wiertz, Emmanuel and Khanna, Rajiv (2001) Targeting of EBNA1 for rapid intracellular degradation overrides the inhibitory effects of the Gly-Ala repeat domain and restores CD8+T cell recognition. Journal of Biological Chemistry, 276 36: 33353-33360. doi:10.1074/jbc.M104535200
Sherritt, M., Bharadwaj, M., Khanna, R. and Moss, D. J. (2001) Contrasting Epstein-Barr virus-specific cytotoxic T cell responses to HLA A2-restricted epitopes in humans and HLA transgenic mice: implications for vaccine design. Vaccine, 19 27: 3769-3777. doi:10.1016/S0264-410X(01)00085-8
Immunotherapeutic strategies for EBV-associated malignancies
Khanna, R., Tellam, J., Duraiswamy, J. and Cooper, L. (2001) Immunotherapeutic strategies for EBV-associated malignancies. Trends in Molecular Medicine, 76 6: 270-276. doi:10.1016/S1471-4914(01)02002-0
White, C. A., Thomson, S. A., Cooper, L., van Endert, P. M., Tampe, R., Coupar, B., Qiu, L., Parsons, P. G., Moss, D. J. and Khanna, R. (2000) Constitutive transduction of peptide transporter and HLA genes restores antigen processing function and cytotoxic T cell-mediated immune recognition of human melanoma cells. International Journal of Cancer, 75 4: 590-595. doi:10.1002/(SICI)1097-0215(19980209)75:4<590::AID-IJC16>3.0.CO;2-D
Khanna, R., Bell, S., Sherritt, M., Galbraith, A., Burrows, S. R., Rafter, L., Clarke, B., Slaughter, R., Falk, M. C., Douglass, J., Williams, T., Elliott, S. L. and Moss, D. J. (1999) Activation and adoptive transfer of Epstein-Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease. Proceedings of the National Academy of Sciences of the United States of America, 96 18: 10391-10396. doi:10.1073/pnas.96.18.10391
Kienzle, Norbert, Sculley, Tom B., Greco, Sonia and Khanna, Rajiv (1999) Cutting Edge: Silencing virus-specific cytotoxic T cell-mediated immune recognition by differential splicing: A novel implication of RNA processing for antigen presentation. Journal of Immunology, 162 12: 6963-6966.
Khanna, Rajiv, Silins, Sharon L., Weng, Zhiping, Gatchell, David, Burrows, Scott R. and Cooper, Leanne (1999) Cytotoxic T cell recognition of allelic variants of HLA B35 bound to an Epstein-Barr virus epitope: influence of peptide conformation and TCF-peptide interaction.. European Journal of Immunology, 29 5: 1587-1597. doi:10.1002/(SICI)1521-4141(199905)29:05
Misko, Ihor S., Cross, Simone M., Khanna, Rajiv, Elliott, Suzanne L., Schmidt, Christopher, Pye, Stephanie J. and Silins, Sharon L. (1999) Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: Implications for molecular mimicry in autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America, 96 5: 2279-2284. doi:10.1073/pnas.96.5.2279
Khanna, Rajiv, Sherritt, Martina and Burrows, Scott R. (1999) EBV structural antigens, gp350 and gp85, as targets for ex vivo virus-specific CTL during acute infectious mononucleosis: Potential use of gp350/gp85 CTL epitopes for vaccine design. Journal of Immunology, 162 5: 3063-3069.
Burrows, Scott R., Khanna, Rajiv and Moss, Denis J. (1999) Direct alloreactivity by human cytotoxic T lymphocytes can be inhibited by altered peptide ligand antagonism. Blood, 93 3: 1020-1024.
Faulkner, Glenda C., Burrows, Scott R., Khanna, Rajiv, Moss, Denis J., Bird, A. Graham and Crawford, Dorothy H. (1999) X-linked agammaglobulinemia patients are not infected with Epstein-Barr virus: Implications for the biology of the virus. Journal of Virology, 73 2: 1555-1564.
Moss, D., Khanna, R., Sherritt, M., Elliott, S. L. and Burrows, S. R. (1999) Developing immunotherapeutic strategies for the control of Epstein-Barr virus-associated malignancies.. Journal of acquired immune deficiency syndromes and human retrovirology, 21 S80-S83.
Immune control of EBV-associated diseases and its implication for vaccine design.
Khanna, R., Moss, D. J. and Burrows, S. R. (1999) Immune control of EBV-associated diseases and its implication for vaccine design.. Immunological Reviews, 70 49-64.
The influence of anti-viral T cell responses on the alloreactive repertoire
Burrows, S. R., Khanna, R., Silins, S. L. and Moss, D. (1999) The influence of anti-viral T cell responses on the alloreactive repertoire. Immunology Today, 20 5: 203-207. doi:10.1016/S0167-5699(98)01429-7
Khanna, R., Moss, D. and Burrows, S. R. (1999) Vaccine strategies against Epstein-Barr virus-associated diseases: lessons from studies on cytotoxic T-cell-mediated immune regulation.. Immunological Reviews, 170 49-64. doi:10.1111/j.1600-065X.1999.tb01328.x
Will a vaccine to nasopharyngeal carcinoma retain orphan status?
Moss, D. J., Khanna, R. and Bharadwaj, M. (2002). Will a vaccine to nasopharyngeal carcinoma retain orphan status?. In: Developments in Biologicals. Orphan vaccines - Bridging the gap, Palm Cove, Queensland, (67-71). 25-29 Aug, 2001.
Strategies for improving T-cell manufacturing for adoptive immunotherapies
Doctor Philosophy — Principal Advisor
Developing antibody-based therapy to treat acute Epstein-Barr virus infection and prevent its associated diseases
Doctor Philosophy — Principal Advisor
Other advisors:
Understanding the mechanisms that promote functional immunological control of human cytomegalovirus in solid organ transplant patients
Doctor Philosophy — Associate Advisor
T cell-mediated immune regulation of BK Virus
(2018) Doctor Philosophy — Principal Advisor
Molecular characterisation of Epstein-Barr virus-specific B cell response
(2015) Doctor Philosophy — Principal Advisor
T cell immune response to human cytomegalovirus in latency and reactivation
(2012) Doctor Philosophy — Principal Advisor
Other advisors:
Persistent Virus infection and T cell Receptor Selection
(2009) Doctor Philosophy — Principal Advisor
Other advisors:
Virus-Specific T Cell Dynamics in Health and Disease
(2008) Doctor Philosophy — Principal Advisor
Developing immunotherapeutic strategies for the treatment of Hodgkin's disease and nasopharyngeal carcinoma
(2004) Doctor Philosophy — Principal Advisor
ROLE OF EPSTEIN-BARR VIRUS ONCOGENES IN THE CONTROL OF EBV-ASSOCIATED TUMOURS
(2003) Doctor Philosophy — Principal Advisor
Characteristics of Human Cytomegalovirus specific T-Cells in Glioblastoma Multiform
(2015) Master Philosophy — Associate Advisor
The adaptive immune response to Epstein-Barr virus.
(2015) Doctor Philosophy — Associate Advisor
Other advisors:
The Antitumor Activity of a Novel Diterpene Ester
(2014) Doctor Philosophy — Associate Advisor
Other advisors: