Associate Professor Jane Nikles

Principal Research Fellow

RECOVER Injury Research Centre
Faculty of Health and Behavioural Sciences

Principal Research Fellow

UQ Centre for Clinical Research
Faculty of Medicine
catherine.nikles@uq.edu.au
+61 7 334 65025

Overview

I am a registered medical practitioner with a PhD from The University of Queensland. My doctoral work was in the field of population health, and focused on the use of N-of-1 trial methodology in clinical practice. I have two major research areas: N-of-1 trials/Single Case Experimental Designs (SCEDs), and whiplash and other musculoskeletal pain after Road Traffic Crashes.

I played a key role in setting up and sustaining UQ’s N-of-1 trials Unit since 1998, and am a key driver of its success, resulting in UQ becoming a world leader in N-of-1 trials since 2009. . Building on my 20 year clinical research career at UQ, I lead the research program at UQCCR in N-of-1 trials, and am a recognised leader in this field both in Australia and internationally. In addition, my skills include trial design and management more broadly.

I am also working at Recover Injury Research Centre in the field of recovery following Road Traffic injuries. Within the Designing Better Therapies research program, my main focus is on improving early management and reducing opioid prescribing for minor musculoskeletal injuries after Road Traffic Crashes. My other area of research is in applying Single Case Experimental Designs to work towards better therapies after injury, especially when caused by Road Traffic Crashes.

Research Interests

  • Clinical trials, n-of-1 trials, research methodology, personalised medicine, individual treatments
  • Single Case Experimental Designs
  • Whiplash, minor musculoskeletal injury, opioid prescribing
  • ADHD, children, sleep
  • Melatonin
  • Parkinson's Disease
  • Skin cancer prevention, improving children's sun protection practices

Qualifications

  • Doctor of Philosophy, The University of Queensland
  • MBBS, The University of Queensland

Publications

View all Publications

Supervision

  • (2019) Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Available Projects

  • Recent research by our group has shown that opioids are inappropriately prescribed for people with musculoskeletal pain after a road traffic crash. This project will explore this issue by longitudinal investigation of opioid use after injury and by using qualitative methods to explore reasons underlying opioid use in injured people and health care providers. It will also explore the physiotherapist's role in preventing opioid misuse.

  • N-of-1 trials in health care, melatonin, complementary and alternative medicines.

    Projects available mostly on clinical neuroscience topics – eg sleep, pain – but discussion on other topics welcome.

    Please contact me on uqjnikle@uq.edu.au to discuss several available projects.

View all Available Projects

Publications

Featured Publications

Book

Book Chapter

  • Nikles, Jane and Mitchell, Geoffrey (2015). Introduction. In Jane Nikles and Geoffrey Mitchell (Ed.), The essential guide to N-of-1 trials in health (pp. 1-8) Dordrecht, The Netherlands: Springer. doi:10.1007/978-94-017-7200-6_1

  • Nikles, Jane (2015). What are N-of-1 Trials?. In Jane Nikles and Geoffrey Mitchell (Ed.), The essential guide to N-of-1 trials in health (pp. 9-17) Dordecht, Netherlands: Springer. doi:10.1007/978-94-017-7200-6_2

  • Nikles, Jane (2015). Where Are N-of-1 Trials Headed?. In Jane Nikles and Geoffrey Mitchell (Ed.), The essential guide to N-of-1 trials in health (pp. 233-241) Dordrecht, The Netherlands: Springer. doi:10.1007/978-94-017-7200-6_17

  • Nikles, C. J., Mitchell, G. K., Del Mar, C. B. and Clavarino, A. (2005). Individualised medication effectiveness tests as a means of targeting stimulants to responders in attention deficit hyperactivity disorder. In M. P. Larimer (Ed.), Attention Deficit Hyperactivity Disorder Research Developments 1 ed. (pp. 169-187) New York, U.S.A.: Nova Science.

Journal Article

Conference Publication

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision

  • (2019) Doctor Philosophy — Associate Advisor

    Other advisors:

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Recent research by our group has shown that opioids are inappropriately prescribed for people with musculoskeletal pain after a road traffic crash. This project will explore this issue by longitudinal investigation of opioid use after injury and by using qualitative methods to explore reasons underlying opioid use in injured people and health care providers. It will also explore the physiotherapist's role in preventing opioid misuse.

  • N-of-1 trials in health care, melatonin, complementary and alternative medicines.

    Projects available mostly on clinical neuroscience topics – eg sleep, pain – but discussion on other topics welcome.

    Please contact me on uqjnikle@uq.edu.au to discuss several available projects.