The University of Queensland

Frontiers of COVID-19: Scientific and clinical aspects of the novel coronavirus 2019

Sasan Adibi, Paul Griffin, Melvin Sanicas, Maryam Rashidi and Francesco Lanfranchi eds. (2022). Frontiers of COVID-19: Scientific and clinical aspects of the novel coronavirus 2019. Cham, Switzerland: Springer. doi: 10.1007/978-3-031-08045-6

The Road Ahead (Editors)

Adibi, Sasan, Griffin, Paul, Sanicas, Melvin, Rashidi, Maryam and Lanfranchi, Francesco (2022). The Road Ahead (Editors). Frontiers of COVID-19: Scientific and Clinical Aspects of the Novel Coronavirus 2019. (pp. 639-650) Springer International Publishing. doi: 10.1007/978-3-031-08045-6_31

Diloxanide furoate

Eisemann, Jared E. and Griffin, Paul M. (2017). Diloxanide furoate. Kucers’ the use of antibiotics: A clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs. (pp. 3195-3199) edited by M. Lindsay Grayson, Sara E. Cosgrove, Suzanne Crowe, William Hope, James S. McCarthy, John Mills, Johan W. Mouton and David L. Paterson. Boca Raton, FL United States: CRC Press. doi: 10.1201/9781315152110

Furazolidone (furazolidine)

Doshi, Jaslyn and Griffin, Paul M. (2017). Furazolidone (furazolidine). Kucers’ the use of antibiotics: A clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs. (pp. 3187-3194) edited by M. Lindsay Grayson, Sara E. Cosgrove, Suzanne Crowe, William Hope, James S. McCarthy, John Mills, Johan W. Mouton and David L. Paterson. Boca Raton, FL United States: CRC Press. doi: 10.1201/9781315152110

Niclosamide

Griffin, Paul M. and McCarthy, James (2017). Niclosamide. Kucers’ the use of antibiotics: A clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs. (pp. 3405-3409) edited by M. Lindsay Grayson, Sara E. Cosgrove, Suzanne Crowe, William Hope, James S. McCarthy, John Mills, Johan W. Mouton and David L. Paterson. Boca Raton, FL United States: CRC Press. doi: 10.1201/9781315152110

Australian Bat Lyssavirus

Griffin, Paul (2014). Australian Bat Lyssavirus. Infectious Disease and Antimicrobial Agents. (pp. 1-1) edited by Victor L. Yu, Rainer Weber and Didier Raoult. Pittsburgh, PA, USA: Antimicrobe.

Barmah Forest Virus

Griffin, Paul (2014). Barmah Forest Virus. Infectious Disease and Antimicrobial Agents. (pp. 1-1) edited by Victor L. Yu, Rainer Weber and Didier Raoult. Pittsburgh, PA, USA: Antimicrobe.

Menangle

Griffin, P. M. (2014). Menangle. Infectious Disease and Antimicrobial Agents. (pp. 1-1) Pittsburgh, PA, United States: Antimicrobe.

Ross River Virus

Griffin, Paul (2014). Ross River Virus. Infectious Disease and Antimicrobial Agents. (pp. 1-1) Pittsburgh, PA, United States: Antimicrobe.

Diloxanide furoate

Griffin, Paul M. (2010). Diloxanide furoate. Kucers' The Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic and Antiviral Drugs. (pp. 2121-2124) edited by M. Lindsay Grayson, Suzanne M. Crowe, James S. McCarthy, John Mills, Johan W. Mouton, S. Ragnar Norrby, David L. Paterson and Michael A. Pfaller. Boca Raton, FL, USA: CRC Press. doi: 10.1201/b13787-206

Furazolidone (furazolidine)

Griffin, Paul M. (2010). Furazolidone (furazolidine). Kucers' The Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic and Antiviral Drugs. (pp. 2114-2120) edited by M. Lindsay Grayson, Suzanne M. Crowe, James S. McCarthy, John Mills, Johan W. Mouton, S. Ragnar Norrby, David L. Paterson and Michael A. Pfaller. Boca Raton, FL, USA: CRC Press. doi: 10.1201/b13787-205

Niclosamide

Griffin, Paul M. and McCarthy, James (2010). Niclosamide. Kucers' the use of antibiotics: a clinical review of antibacterial, antifungal, antiparasitic and antiviral drugs. (pp. 2293-2296) edited by M. Lindsay Grayson, Suzanne M. Crowe, James S. McCarthy, John Mills, Johan W. Mouton, S. Ragnar Norrby, David L. Paterson and Michael A. Pfaller. Boca Raton, FL, United States: CRC Press. doi: 10.1201/b13787-232

Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial

Chappell, Keith J., Mordant, Francesca L., Amarilla, Alberto A., Modhiran, Naphak, Liang, Benjamin, Li, Zheyi, Wijesundara, Danushka K., Lackenby, Julia A., Griffin, Paul, Bennet, Jillian K., Hensen, Luca, Zhang, Wuji, Nguyen, Thi H.O., Tran, Mai H., Tapley, Peter, Barnes, James, Reading, Patrick C., Kedzierska, Katherine, Ranasinghe, Charani, Subbarao, Kanta, Watterson, Daniel, Young, Paul R. and Munro, Trent P. (2023). Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial. eBioMedicine, 97 104842, 104842. doi: 10.1016/j.ebiom.2023.104842

Strong CD4+T-Cell Responses to Ancestral and Variant Spike Proteins Are Established by NVX-CoV2373 Severe Acute Respiratory Syndrome Coronavirus 2 Primary Vaccination

Fries, Louis, Formica, Neil, Mallory, Raburn M, Zhou, Haixia, Plested, Joyce S, Kalkeri, Raj, Moldovan, Ioana, Patel, Nita, Albert, Gary, Robinson, Michelle, Cho, Iksung, Chau, Gordon, Dubovsky, Filip, Glenn, Gregory M, Adams, Mark, Arya, Mark, Athan, Eugene, Berger, Ira, Bradley, Paul, Glover, Richard, Griffin, Paul, Kim, Joshua, Kitchener, Scott, Klein, Terry, Leah, Amber, Lemech, Charlotte, Lickliter, Jason, Manning, Mary Beth, Napier-Flood, Fiona ... Turner, Mark (2023). Strong CD4+T-Cell Responses to Ancestral and Variant Spike Proteins Are Established by NVX-CoV2373 Severe Acute Respiratory Syndrome Coronavirus 2 Primary Vaccination. Journal of Infectious Diseases, 228 (6), 734-741. doi: 10.1093/infdis/jiad163

Barriers to optimal management of syphilis in pregnancy and congenital syphilis in south-east Queensland: a qualitative investigation

Fowler, James A., Warzywoda, Sarah, Nourse, Clare, Wu, Mandy, Britton, Sumudu, Rowling, Diane, Griffin, Paul, Lazarou, Mattea, Hamilton, Zoe and Dean, Judith A. (2023). Barriers to optimal management of syphilis in pregnancy and congenital syphilis in south-east Queensland: a qualitative investigation. Sexual Health. doi: 10.1071/sh23119

Syphilis in pregnancy: a qualitative investigation of healthcare provider perspectives on barriers to syphilis screening during pregnancy in south-east Queensland

Warzywoda, Sarah, Fowler, James A., Nourse, Clare, Wu, Mandy, Britton, Sumudu, Rowling, Diane, Griffin, Paul, Lazarou, Mattea, Hamilton, Zoe and Dean, Judith A. (2023). Syphilis in pregnancy: a qualitative investigation of healthcare provider perspectives on barriers to syphilis screening during pregnancy in south-east Queensland. Sexual Health, 20 (4), 330-338. doi: 10.1071/sh22193

Expanding the geographic boundaries of Melioidosis in Queensland, Australia

Gassiep, Ian, Grey, Victoria, Thean, Li Jun, Farquhar, Drew, Clark, Julia E., Ariotti, Lawrence, Graham, Rikki, Jennison, Amy V., Bergh, Haakon, Anuradha, Satyamurthy, Dyer, Wendy, James, Christian, Huang, Andrea, Putt, Elise, Pakeerathan, Veenaa, Griffin, Paul M. and Harris, Patrick N. A. (2023). Expanding the geographic boundaries of Melioidosis in Queensland, Australia. The American Journal of Tropical Medicine and Hygiene, 108 (6), 1215-1219. doi: 10.4269/ajtmh.23-0002

Improving care for patients with Clostridioides difficile infection: A clinical practice and healthcare systems perspective

Hocking, Lucy, Wilcox, Mark, Petrosillo, Nicola, Griffin, Paul, Steiner, Theodore, Attara, Gail, Doré, Joel, Cabling, Mark, Stockwell, Stephanie, Romanelli, Robert J. and Marjanovic, Sonja (2023). Improving care for patients with Clostridioides difficile infection: A clinical practice and healthcare systems perspective. Frontiers in Medicine, 9 1033417, 1-21. doi: 10.3389/fmed.2022.1033417

A multinational Delphi consensus to end the COVID-19 public health threat

Lazarus, Jeffrey V., Romero, Diana, Kopka, Christopher J., Karim, Salim Abdool, Abu-Raddad, Laith J., Almeida, Gisele, Baptista-Leite, Ricardo, Barocas, Joshua A., Barreto, Mauricio L., Bar-Yam, Yaneer, Bassat, Quique, Batista, Carolina, Bazilian, Morgan, Chiou, Shu-Ti, del Rio, Carlos, Dore, Gregory J., Gao, George F., Gostin, Lawrence O., Hellard, Margaret, Jimenez, Jose L., Kang, Gagandeep, Lee, Nancy, Matičič, Mojca, McKee, Martin, Nsanzimana, Sabin, Oliu-Barton, Miquel, Pradelski, Bary, Pyzik, Oksana, Rabin, Kenneth ... Øvrehus, Anne (2022). A multinational Delphi consensus to end the COVID-19 public health threat. Nature, 611 (7935), 332-345. doi: 10.1038/s41586-022-05398-2

Safety and immunogenicity following a homologous booster dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): a secondary analysis of a randomised, placebo-controlled, phase 2 trial

Mallory, Raburn M, Formica, Neil, Pfeiffer, Susan, Wilkinson, Bethanie, Marcheschi, Alex, Albert, Gary, McFall, Heather, Robinson, Michelle, Plested, Joyce S, Zhu, Mingzhu, Cloney-Clark, Shane, Zhou, Bin, Chau, Gordon, Robertson, Andreana, Maciejewski, Sonia, Hammond, Holly L, Baracco, Lauren, Logue, James, Frieman, Matthew B, Smith, Gale, Patel, Nita, Glenn, Gregory M, Adams, Mark, Arya, Mark, Athan, Eugene, Berger, Ira, Bradley, Paul, Briskin, Toby, Glover II, Richard ... Turner, Mark (2022). Safety and immunogenicity following a homologous booster dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): a secondary analysis of a randomised, placebo-controlled, phase 2 trial. The Lancet Infectious Diseases, 22 (11), 1565-1576. doi: 10.1016/S1473-3099(22)00420-0

Japanese encephalitis - a recent rise in Australian cases

Armstrong, Mark, Grey, Victoria and Griffin, Paul (2022). Japanese encephalitis - a recent rise in Australian cases. Medicine Today, 23 (8), 49-53.

Efficacy and safety of a universal influenza A vaccine (MVA-NP+M1) in adults when given after seasonal quadrivalent influenza vaccine immunisation (FLU009): a phase 2b, randomised, double-blind trial

Evans, Thomas G, Bussey, Louise, Eagling-Vose, Elizabeth, Rutkowski, Kathryn, Ellis, Chris, Argent, Chris, Griffin, Paul, Kim, Joshua, Thackwray, Susan, Shakib, Sepehr, Doughty, Julia, Gillies, John, Wu, Jian, Druce, Julian, Pryor, Melinda and Gilbert, Sarah (2022). Efficacy and safety of a universal influenza A vaccine (MVA-NP+M1) in adults when given after seasonal quadrivalent influenza vaccine immunisation (FLU009): a phase 2b, randomised, double-blind trial. The Lancet Infectious Diseases, 22 (6), 857-866. doi: 10.1016/S1473-3099(21)00702-7

Safety, tolerability, pharmacokinetics, and pharmacodynamics of coadministered Ruxolitinib and Artemether-Lumefantrine in healthy adults

Chughlay, M. Farouk, Barnes, Karen I., El Gaaloul, Myriam, Abla, Nada, Möhrle, Jörg J., Griffin, Paul, van Giersbergen, Paul, Reuter, Stephanie E., Schultz, Hayley B., Kress, Anita, Tapley, Peter, Webster, Rebecca A., Wells, Timothy, McCarthy, James S., Barber, Bridget E., Marquart, Louise, Boyle, Michelle J., Engwerda, Christian R. and Chalon, Stephan (2022). Safety, tolerability, pharmacokinetics, and pharmacodynamics of coadministered Ruxolitinib and Artemether-Lumefantrine in healthy adults. Antimicrobial Agents and Chemotherapy, 66 (1) e01584-21, e0158421. doi: 10.1128/AAC.01584-21

Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine

Webster, Rebecca, Sekuloski, Silvana, Odedra, Anand, Woolley, Stephen, Jennings, Helen, Amante, Fiona, Trenholme, Katharine R., Healer, Julie, Cowman, Alan F., Eriksson, Emily M., Sathe, Priyanka, Penington, Jocelyn, Blanch, Adam J., Dixon, Matthew W. A., Tilley, Leann, Duffy, Michael F., Craig, Alister, Storm, Janet, Chan, Jo-Anne, Evans, Krystal, Papenfuss, Anthony T., Schofield, Louis, Griffin, Paul, Barber, Bridget E., Andrew, Dean, Boyle, Michelle J., de Labastida Rivera, Fabian, Engwerda, Christian and McCarthy, James S. (2021). Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine. BMC Medicine, 19 (1) 293, 293. doi: 10.1186/s12916-021-02150-x

Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial

Chappell, Keith J., Mordant, Francesca L., Li, Zheyi, Wijesundara, Danushka K., Ellenberg, Paula, Lackenby, Julia A., Cheung, Stacey T. M., Modhiran, Naphak, Avumegah, Michael S., Henderson, Christina L., Hoger, Kym, Griffin, Paul, Bennet, Jillian, Hensen, Luca, Zhang, Wuji, Nguyen, Thi H. O., Marrero-Hernandez, Sara, Selva, Kevin J., Chung, Amy W., Tran, Mai H., Tapley, Peter, Barnes, James, Reading, Patrick C., Nicholson, Suellen, Corby, Stavroula, Holgate, Thomas, Wines, Bruce D., Hogarth, P Mark, Kedzierska, Katherine ... Munro, Trent P. (2021). Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial. The Lancet Infectious Diseases, 21 (10), 1383-1394. doi: 10.1016/S1473-3099(21)00200-0

A first-in-human study of BLZ-100 (tozuleristide) demonstrates tolerability and safety in skin cancer patients

Yamada, Miko, Miller, Dennis M., Lowe, Melinda, Rowe, Casey, Wood, Dominic, Soyer, H. Peter, Byrnes-Blake, Kelly, Parrish-Novak, Julia, Ishak, Laura, Olson, James M., Brandt, Gordon, Griffin, Paul, Spelman, Lynda and Prow, Tarl W. (2021). A first-in-human study of BLZ-100 (tozuleristide) demonstrates tolerability and safety in skin cancer patients. Contemporary Clinical Trials Communications, 23 100830, 1-6. doi: 10.1016/j.conctc.2021.100830

Addressing the crisis of congenital syphilis: Key findings from an evaluation of the management of syphilis in pregnancy and the newborn in South‐East Queensland

Wu, Mandy, Seel, Mandy, Britton, Sumudu, Dean, Judith A., Lazarou, Mattea, Safa, Huda, Griffin, Paul and Nourse, Clare (2021). Addressing the crisis of congenital syphilis: Key findings from an evaluation of the management of syphilis in pregnancy and the newborn in South‐East Queensland. Australian and New Zealand Journal of Obstetrics and Gynaecology, 62 (1) ajo.13424, 91-97. doi: 10.1111/ajo.13424

Pentosan polysulfate sodium for Ross River virus-induced arthralgia: a phase 2a, randomized, double-blind, placebo-controlled study

Krishnan, Ravi, Duiker, Melanie, Rudd, Penny A., Skerrett, Donna, Pollard, James G. D., Siddel, Carolyn, Rifat, Rifat, Ng, Jennifer H. K., Georgius, Peter, Hererro, Lara J. and Griffin, Paul (2021). Pentosan polysulfate sodium for Ross River virus-induced arthralgia: a phase 2a, randomized, double-blind, placebo-controlled study. BMC Musculoskeletal Disorders, 22 (1) 271. doi: 10.1186/s12891-021-04123-w

Defining the antimalarial activity of cipargamin in healthy volunteers experimentally infected with blood-stage Plasmodium falciparum

McCarthy, James S., Abd-Rahman, Azrin N., Collins, Katharine A., Marquart, Louise, Griffin, Paul, Kummel, Anne, Fuchs, Aline, Winnips, Cornelis, Mishra, Vishal, Csermak-Renner, Katalin, Jain, J. Prakash and Gandhi, Preetam (2021). Defining the antimalarial activity of cipargamin in healthy volunteers experimentally infected with blood-stage Plasmodium falciparum. Antimicrobial Agents and Chemotherapy, 65 (2) e01423-20. doi: 10.1128/aac.01423-20

Phase 1-2 trial of a SARS-CoV-2 recombinant spike protein nanoparticle vaccine

Keech, Cheryl, Albert, Gary, Cho, Iksung, Robertson, Andreana, Reed, Patricia, Neal, Susan, Plested, Joyce S., Zhu, Mingzhu, Cloney-Clark, Shane, Zhou, Haixia, Smith, Gale, Patel, Nita, Frieman, Matthew B., Haupt, Robert E., Logue, James, McGrath, Marisa, Weston, Stuart, Piedra, Pedro A., Desai, Chinar, Callahan, Kathleen, Lewis, Maggie, Price-Abbott, Patricia, Formica, Neil, Shinde, Vivek, Fries, Louis, Lickliter, Jason D., Griffin, Paul, Wilkinson, Bethanie and Glenn, Gregory M. (2020). Phase 1-2 trial of a SARS-CoV-2 recombinant spike protein nanoparticle vaccine. The New England Journal of Medicine, 383 (24), 2320-2332. doi: 10.1056/NEJMoa2026920

A phase 1, randomized, placebo-controlled study to evaluate the safety and immunogenicity of an mRNA-based RSV prefusion F protein vaccine in healthy younger and older adults

Aliprantis, Antonios O., Shaw, Christine A., Griffin, Paul, Farinola, Nicholas, Railkar, Radha A., Cao, Xin, Liu, Wen, Sachs, Jeffrey R., Swenson, Christine J., Lee, Heather, Cox, Kara S., Spellman, Daniel S., Winstead, Colleen J., Smolenov, Igor, Lai, Eseng, Zaks, Tal, Espeseth, Amy S. and Panther, Lori (2020). A phase 1, randomized, placebo-controlled study to evaluate the safety and immunogenicity of an mRNA-based RSV prefusion F protein vaccine in healthy younger and older adults. Human Vaccines and Immunotherapeutics, 17 (5), 1-14. doi: 10.1080/21645515.2020.1829899

Association between minimum inhibitory concentration, beta-lactamase genes and mortality for patients treated with piperacillin/tazobactam or meropenem from the MERINO study

Henderson, A., Paterson, D. L., Chatfield, M. D., Tambyah, P. A., Lye, D. C., De, P. P., Lin, R. T. P., Chew, K. L., Yin, M., Lee, T. H., Yilmaz, M., Cakmak, R., Alenazi, T. H., Arabi, Y. M., Falcone, M., Bassetti, M., Righi, E., Rogers, B.A., Kanj, S. S., Bhally, H., Iredell, J., Mendelson, M., Boyles, T. H., Looke, D. F. M., Runnegar, N. J., Miyakis, S., Walls, G., AI Khamis, M., Zikri, A. ... For the MERINO Trial Investigators and the Australasian Society for Infectious Disease Clinical Research Network (ASID-CRN) (2020). Association between minimum inhibitory concentration, beta-lactamase genes and mortality for patients treated with piperacillin/tazobactam or meropenem from the MERINO study. Clinical Infectious Diseases, 73 (11), e3842-e3850. doi: 10.1093/cid/ciaa1479

Pharmacokinetics and pharmacodynamics of a proposed pegfilgrastim biosimilar MSB11455 versus the reference pegfilgrastim Neulasta® in healthy subjects: a randomized, double-blind trial

Lickliter, Jason, Kanceva, Radmila, Vincent, Emmanuelle, Schueler, Armin, Harrison-Moench, Eleanor, Yue, Corinne Seng, Stahl, Michael, Ullmann, Martin, Ghori, Vishal and Griffin, Paul (2020). Pharmacokinetics and pharmacodynamics of a proposed pegfilgrastim biosimilar MSB11455 versus the reference pegfilgrastim Neulasta® in healthy subjects: a randomized, double-blind trial. Clinical Therapeutics, 42 (8), 1508-1518.e1. doi: 10.1016/j.clinthera.2020.05.020

Antimalarial activity of artefenomel against asexual parasites and transmissible gametocytes during experimental blood-stage Plasmodium vivax infection

Collins, Katharine A., Abd-Rahman, Azrin N., Marquart, Louise, Ballard, Emma, Gobeau, Nathalie, Griffin, Paul, Chalon, Stephan, Möhrle, Jörg J. and McCarthy, James S. (2020). Antimalarial activity of artefenomel against asexual parasites and transmissible gametocytes during experimental blood-stage Plasmodium vivax infection. The Journal of Infectious Diseases, 225 (6), 1062-1069. doi: 10.1093/infdis/jiaa287

Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a first-in-human, randomised, controlled, phase 1 study

Playford, Elliott Geoffrey, Munro, Trent, Mahler, Stephen M., Elliott, Suzanne, Gerometta, Michael, Hoger, Kym L., Jones, Martina L., Griffin, Paul, Lynch, Kathleen D., Carroll, Heidi, El Saadi, Debra, Gilmour, Margaret E., Hughes, Benjamin, Hughes, Karen, Huang, Edwin, de Bakker, Christopher, Klein, Reuben, Scher, Mark G., Smith, Ina L., Wang, Lin-Fa, Lambert, Stephen B., Dimitrov, Dimiter S., Gray, Peter P. and Broder, Christopher C. (2020). Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a first-in-human, randomised, controlled, phase 1 study. The Lancet Infectious Diseases, 20 (4), 445-454. doi: 10.1016/S1473-3099(19)30634-6

A single-dose combination study with the experimental antimalarials artefenomel and DSM265 to determine safety and antimalarial activity against blood-stage Plasmodium falciparum in healthy volunteers

McCarthy, James S., Rückle, Thomas, Elliott, Suzanne L., Ballard, Emma, Collins, Katharine A., Marquart, Louise, Griffin, Paul, Chalon, Stephan and Möhrle, Jörg J. (2020). A single-dose combination study with the experimental antimalarials artefenomel and DSM265 to determine safety and antimalarial activity against blood-stage Plasmodium falciparum in healthy volunteers. Antimicrobial Agents and Chemotherapy, 64 (1) e01371-19, e01371-19. doi: 10.1128/AAC.01371-19

Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: a randomized double blinded phase I/IIa trial

Chandra, Janin, Woo, Wai-Ping, Dutton, Julie L., Xu, Yan, Li, Bo, Kinrade, Sally, Druce, Julian, Finlayson, Neil, Griffin, Paul, Laing, Kerry J., Koelle, David M. and Frazer, Ian H. (2019). Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: a randomized double blinded phase I/IIa trial. PLoS One, 14 (12) e0226320, 1-20. doi: 10.1371/journal.pone.0226320

DSM265 at 400 milligrams clears asexual stage parasites but not mature gametocytes from the blood of healthy subjects experimentally infected with Plasmodium falciparum

Collins, Katharine A., Rueckle, Thomas, Elliott, Suzanne, Marquart, Louise, Ballard, Emma, Chalon, Stephan, Griffin, Paul, Moehrle, Joern J. and McCarthy, James S. (2019). DSM265 at 400 milligrams clears asexual stage parasites but not mature gametocytes from the blood of healthy subjects experimentally infected with Plasmodium falciparum. Antimicrobial Agents and Chemotherapy, 63 (4) e01837-18. doi: 10.1128/AAC.01837-18

Qualitative study investigating the underlying motivations of healthy participants in phase I clinical trials

Manton, Kerry J., Gauld, Cassandra S., White, Katherine M., Griffin, Paul M. and Elliott, Suzanne L. (2019). Qualitative study investigating the underlying motivations of healthy participants in phase I clinical trials. BMJ Open, 9 (1) e024224, e024224. doi: 10.1136/bmjopen-2018-024224

Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a randomised, first-in-human phase 1 study

Playford, Elliott, Munro, Trent, Mahler, Stephen M., Elliott, Suzanne, Gerometta, Michael, Hoger, Kym L., Jones, Martina L., Griffin, Paul, Lynch, Kathleen D., Carroll, Heidi, El Saadi, Debra, Gilmour, Margaret E., Hughes, Benjamin, Hughes, Karen, Huang, Edwin, de Bakker, Christopher, Klein, Reuben, Scher, Mark G., Smith, Ina L., Wang, Lin-Fa, Lambert, Stephen B., Dimitrov, Dimiter S., Gray, Peter P. and Broder, Christopher C. (2019). Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a randomised, first-in-human phase 1 study. SSRN Electronic Journal. doi: 10.2139/ssrn.3457427

Effect of piperacillin-tazobactam vs meropenem on 30-day mortality for patients with E coli or Klebsiella pneumoniae bloodstream infection and ceftriaxone resistance: a randomized clinical trial

Harris, Patrick N. A., Tambyah, Paul A., Lye, David C., Mo, Yin, Lee, Tau H., Yilmaz, Mesut, Alenazi, Thamer H., Arabi, Yaseen, Falcone, Marco, Bassetti, Matteo, Righi, Elda, Rogers, Benjamin A., Kanj, Souha, Bhally, Hasan, Iredell, Jon, Mendelson, Marc, Boyles, Tom H., Looke, David, Miyakis, Spiros, Walls, Genevieve, Al Khamis, Mohammed, Zikri, Ahmed, Crowe, Amy, Ingram, Paul, Daneman, Nick, Griffin, Paul, Athan, Eugene, Lorenc, Penelope, Baker, Peter ... MERINO Trial Investigators and the Australasian Society for Infectious Disease Clinical Research Network (ASID-CRN) (2018). Effect of piperacillin-tazobactam vs meropenem on 30-day mortality for patients with E coli or Klebsiella pneumoniae bloodstream infection and ceftriaxone resistance: a randomized clinical trial. JAMA, 320 (10), 984-994. doi: 10.1001/jama.2018.12163

Efficacy and safety of methionine aminopeptidase 2 inhibition in type 2 diabetes: a randomised, placebo-controlled clinical trial

Proietto, Joseph, Malloy, Jaret, Zhuang, Dongliang, Arya, Mark, Cohen, Neale D., de Looze, Ferdinandus J., Gilfillan, Christopher, Griffin, Paul, Hall, Stephen, Nathow, Thomas, Oldfield, Geoffrey S., O'Neal, David N., Roberts, Adam, Stuckey, Bronwyn G. A., Yue, Dennis, Taylor, Kristin and Kim, Dennis (2018). Efficacy and safety of methionine aminopeptidase 2 inhibition in type 2 diabetes: a randomised, placebo-controlled clinical trial. Diabetologia, 61 (9), 1918-1922. doi: 10.1007/s00125-018-4677-0

Evaluation of safety and immunogenicity of a group A streptococcus vaccine candidate (MJ8VAX) in a randomized clinical trial

Sekuloski, Silvana, Batzloff, Michael R., Griffin, Paul, Parsonage, William, Elliott, Suzanne, Hartas, Jon, O'Rourke, Peter, Marquart, Louise, Pandey, Manisha, Rubin, Fran A., Carapetis, Jonathan, McCarthy, James and Good, Michael F. (2018). Evaluation of safety and immunogenicity of a group A streptococcus vaccine candidate (MJ8VAX) in a randomized clinical trial. PLoS One, 13 (7) e0198658, e0198658. doi: 10.1371/journal.pone.0198658

Safety, tolerability, acceptability and immunogenicity of an influenza vaccine delivered to human skin by a novel high-density microprojection array patch (Nanopatch™)

Fernando, Germain J. P., Hickling, Julian, Jayashi Flores, Cesar M., Griffin, Paul, Anderson, Christopher D., Skinner, S. Rachel, Davies, Cristyn, Witham, Katey, Pryor, Melinda, Bodle, Jesse, Rockman, Steve, Frazer, Ian H. and Forster, Angus H. (2018). Safety, tolerability, acceptability and immunogenicity of an influenza vaccine delivered to human skin by a novel high-density microprojection array patch (Nanopatch™). Vaccine, 36 (26), 3779-3788. doi: 10.1016/j.vaccine.2018.05.053

The Dynamics of Liver Function Test Abnormalities after Malaria Infection: A Retrospective Observational Study

Woodford, John, Shanks, G Dennis, Griffin, Paul, Chalon, Stephan and McCarthy, James (2018). The Dynamics of Liver Function Test Abnormalities after Malaria Infection: A Retrospective Observational Study. The American Journal of Tropical Medicine and Hygiene, 98 (4), 1113-1119. doi: 10.4269/ajtmh.17-0754

Safety, acceptability and tolerability of uncoated and excipient-coated high density silicon micro-projection array patches in human subjects

Griffin, Paul, Elliot, Suzanne, Krauer, Kenia, Davies, Cristyn, Skinner, Rachel, Anderson, Christopher D. and Forster, Anguis (2017). Safety, acceptability and tolerability of uncoated and excipient-coated high density silicon micro-projection array patches in human subjects. Vaccine, 35 (48), 6676-6684. doi: 10.1016/j.vaccine.2017.10.021

Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study

McCarthy, James S., Lotharius, Julie, Ruckle, Thomas, Chalon, Stephan, Phillips, Margaret A., Elliott, Suzanne, Sekuloski, Silvana, Griffin, Paul, Ng, Caroline L., Fidock, David A., Marquart, Louise, Williams, Noelle S., Gobeau, Nathalie, Bebrevska, Lidiya, Rosario, Maria, Marsh, Kennan and Mohrle, Jorg J. (2017). Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study. The Lancet Infectious Diseases, 17 (6), 626-635. doi: 10.1016/S1473-3099(17)30171-8

First Australian case of disseminated Mycobacterium chimaera infection post-cardiothoracic surgery

Bursle, Evan, Playford, E. Geoffrey, Coulter, Chris and Griffin, Paul (2017). First Australian case of disseminated Mycobacterium chimaera infection post-cardiothoracic surgery. Infection, Disease and Health, 22 (1), 1-5. doi: 10.1016/j.idh.2017.01.003

MALDI-TOF MS meets WGS in a VRE outbreak investigation

Schlebusch, S., Price, G. R., Gallagher, R. L., Horton-Szar, V., Elbourne, L. D. H., Griffin, P., Venter, D. J., Jensen, S. O. and van Hal, S. J. (2017). MALDI-TOF MS meets WGS in a VRE outbreak investigation. European Journal of Clinical Microbiology and Infectious Diseases, 36 (3), 1-5. doi: 10.1007/s10096-016-2824-4

Plasmodium vivax controlled human malaria infection - progress and prospects

Payne, Ruth O., Griffin, Paul M., McCarthy, James S. and Draper, Simon J. (2016). Plasmodium vivax controlled human malaria infection - progress and prospects. Trends in Parasitology, 33 (2), 141-150. doi: 10.1016/j.pt.2016.11.001

Safety and reproducibility of a clinical trial system using induced blood stage Plasmodium vivax infection and its potential as a model to evaluate malaria transmission

Griffin, Paul, Pasay, Cielo, Elliott, Suzanne, Sekuloski, Silvana, Sikulu, Maggy, Hugo, Leon, Khoury, David, Cromer, Deborah, Davenport, Miles, Sattabongkot, Jetsumon, Ivinson, Karen, Ockenhouse, Christian and McCarthy, James (2016). Safety and reproducibility of a clinical trial system using induced blood stage Plasmodium vivax infection and its potential as a model to evaluate malaria transmission. PLoS Neglected Tropical Diseases, 10 (12) e0005139, e0005139. doi: 10.1371/journal.pntd.0005139

A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study

McCarthy, James S., Ruckle, Thomas, Djeriou, Elhadj, Cantalloube, Cathy, Ter-Minassian, Daniel, Baker, Mark, O'Rourke, Peter, Griffin, Paul, Marquart, Louise, van Huijsduijnen, Rob Hooft and Mohrle, Jorg J. (2016). A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study. Malaria Journal, 15 (469) 469, 469. doi: 10.1186/s12936-016-1511-3

Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers

McCarthy, James S., Baker, Mark, O'Rourke, Peter, Marquart, Louise, Griffin, Paul, van huijsduijnen, Rob Hooft and Mohrle, Jorg J. (2016). Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers. Journal of Antimicrobial Chemotherapy, 71 (9), 2620-2627. doi: 10.1093/jac/dkw174

Infectivity of Plasmodium falciparum in malaria-naive individuals is related to knob expression and cytoadherence of the parasite

Stanisic, Danielle I., Gerrard, John, Fink, James, Griffin, Paul M., Liu, Xue Q., Sundac, Lana, Sekuloski, Silvana, Rodriguez, Ingrid B., Pingnet, Jolien, Yang, Yuedong, Zhou, Yaoqi, Trenholme, Katharine R., Wang, Claire Y. T., Hackett, Hazel, Chan, Jo-Anne A., Langer, Christine, Hanssen, Eric, Hoffman, Stephen L., Beeson, James G., McCarthy, James S. and Good, Michael F. (2016). Infectivity of Plasmodium falciparum in malaria-naive individuals is related to knob expression and cytoadherence of the parasite. Infection and Immunity, 84 (9), 2689-2696. doi: 10.1128/IAI.00414-16

An escalating dose study to assess the safety, tolerability and immunogenicity of a Herpes Simplex Virus DNA vaccine, COR-1

Dutton, Julie L., Woo, Wai-Ping, Chandra, Janin, Xu, Yan, Li, Bo, Finlayson, Neil, Griffin, Paul and Frazer, Ian H. (2016). An escalating dose study to assess the safety, tolerability and immunogenicity of a Herpes Simplex Virus DNA vaccine, COR-1. Human Vaccines and Immunotherapeutics, 12 (12), 3079-3088. doi: 10.1080/21645515.2016.1221872

Piperaquine monotherapy of drug-susceptible Plasmodium falciparum infection results in rapid clearance of Parasitemia but is followed by the appearance of Gametocytemia

Pasay, Cielo J., Rockett, Rebecca, Sekuloski, Silvana, Griffin, Paul, Marquart, Louise, Peatey, Christopher, Wang, Claire Y. T., O'Rourke, Peter, Elliott, Suzanne, Baker, Mark, Möhrle, Jörg J. and McCarthy, James S. (2016). Piperaquine monotherapy of drug-susceptible Plasmodium falciparum infection results in rapid clearance of Parasitemia but is followed by the appearance of Gametocytemia. Journal of Infectious Diseases, 214 (1), 105-113. doi: 10.1093/infdis/jiw128

Linking murine and human Plasmodium falciparum challenge models in a translational path for antimalarial drug development

McCarthy, James S., Marquart, Louise, Sekuloski, Silvana, Trenholme, Katherine, Elliott, Suzanne, Griffin, Paul, Rockett, Rebecca, O'Rourke, Peter, Sloots, Theo, Angulo-Barturen, Inigo, Ferrer, Santiago, Jimenez-Diaz, Maria Belen, Martinez, Maria-Santos, van Huijsduijnen, Rob Hoof, Duparc, Stephan, Leroy, Didier, Wells, Timothy N. C., Baker, Mark and Mohrle, Jorg J. (2016). Linking murine and human Plasmodium falciparum challenge models in a translational path for antimalarial drug development. Antimicrobial Agents and Chemotherapy, 60 (6), 3669-3675. doi: 10.1128/AAC.02883-15

Acute vancomycin-resistant enterococcal bacteraemia outbreak analysis in haematology patients: a case-control study

Gassiep, Ian, Armstrong, Mark, Van Havre, Zoe, Schlebusch, Sanmarie, McCormack, Joseph and Griffin, Paul (2015). Acute vancomycin-resistant enterococcal bacteraemia outbreak analysis in haematology patients: a case-control study. Healthcare Infection, 20 (4), 115-123. doi: 10.1071/HI15013

Open-label, single-dose, parallel-group study in healthy volunteers to determine the drug-drug interaction potential between KAE609(Cipargamin) and Piperaquine

Stein, Daniel S, Jain, Jay Prakash, Kangas, Michael, Lefèvre, Gilbert, Machineni, Surendra, Griffin, Paul and Lickliterf, Jason (2015). Open-label, single-dose, parallel-group study in healthy volunteers to determine the drug-drug interaction potential between KAE609(Cipargamin) and Piperaquine. Antimicrobial Agents and Chemotherapy, 59 (6), 3493-3500. doi: 10.1128/AAC.00340-15

Delusions of disseminated fungosis

Gassiep, Ian and Griffin, Paul Matthew (2014). Delusions of disseminated fungosis. Case Reports in Infectious Diseases, 2014 (458028), 1-3. doi: 10.1155/2014/458028

Vancomycin-induced linear IgA with mucosal and ocular involvement: a case report

Dang, Lily V., Byrom, Lisa, Muir, Jim and Griffin, Paul M. (2014). Vancomycin-induced linear IgA with mucosal and ocular involvement: a case report. Infectious Diseases in Clinical Practice, 22 (5), e119-e121. doi: 10.1097/IPC.0000000000000182

Fasting increases serum bilirubin levels in clinically normal, healthy males but not females: a retrospective study from phase I clinical trial participants

Griffin, Paul M., Elliott, Suzanne L. and Manton, Kerry J. (2014). Fasting increases serum bilirubin levels in clinically normal, healthy males but not females: a retrospective study from phase I clinical trial participants. Journal of Clinical Pathology, 67 (6), 529-534. doi: 10.1136/jclinpath-2013-202155

Maldi in infection control (VRE)

Griffin, Paul (2014). Maldi in infection control (VRE). Pathology, 46, S45. doi: 10.1097/01.pat.0000443496.32732.1d

Experimentally induced blood-stage plasmodium vivax infection in healthy volunteers

McCarthy, James S., Griffin, Paul M., Sekuloski, Silvana, Bright, A. Taylor, Rockett, Rebecca, Looke, David, Elliott, Suzanne, Whiley, David, Sloots, Theo, Winzeler, Elizabeth A. and Trenholme, Katharine R. (2013). Experimentally induced blood-stage plasmodium vivax infection in healthy volunteers. Journal of Infectious Diseases, 208 (10), 1688-1694. doi: 10.1093/infdis/jit394

Chronic urticaria following acute hepatitis A

Griffin, Paul M., Kevat, Dev A. S., McCarthy, James S. and Woods, Marion L. (2012). Chronic urticaria following acute hepatitis A. BMJ case reports, 2012 (sep18 1), bcr2012006479-bcr2012006479. doi: 10.1136/bcr-2012-006479

Use of matrix-assisted laser desorption ionization-time of flight mass spectrometry to identify vancomycin-resistant enterococci and investigate the epidemiology of an outbreak

Griffin, Paul M., Price, Gareth R., Schooneveldt, Jacqueline M., Schlebusch, Sanmarie, Tilse, Martyn H., Urbanski, Tess, Hamilton, Brett and Venter, Deon (2012). Use of matrix-assisted laser desorption ionization-time of flight mass spectrometry to identify vancomycin-resistant enterococci and investigate the epidemiology of an outbreak. Journal of Clinical Microbiology, 50 (9), 2918-2931. doi: 10.1128/JCM.01000-12

A pilot randomised trial of induced blood-stage Plasmodium falciparum infections in healthy volunteers for testing efficacy of new antimalarial drugs

McCarthy, James S., Sekuloski, Silvana, Griffin, Paul M., Elliott, Suzanne, Douglas, Nanette, Peatey, Chris, Rockett, Rebecca, O'Rourke, Peter, Marquart, Louise, Hermsen, Cornelius, Duparc, Stephan, Moehrle, Joerg, Trenholme, Katharine R. and Humberstone, Andrew J. (2011). A pilot randomised trial of induced blood-stage Plasmodium falciparum infections in healthy volunteers for testing efficacy of new antimalarial drugs. PLoS ONE, 6 (8) e21914, e21914-1-e21914-8. doi: 10.1371/journal.pone.0021914

Malaria: Part 2

Griffin, Paul and McCarthy, James (2010). Malaria: Part 2. Medical Observer, 23-23.

Malaria: Part 1

Griffin, Paul and McCarthy, James (2010). Malaria: Part 1. Medical Observer, 23-23.

Pharmacokinetic/pharmacodynamic assessment of a proposed biosimilar MSB11455 versus the currently licensed pegfilgrastim: A randomized, double-blind trial

Lickliter, Jason D., Griffin, Paul, Vincent, Emmanuelle, Schuler, Armin, Harrison-Moench, Eleanor, Stahl, Michael, El Bawab, Samer, Kanceva, Radmila and Gascon, Pere (2019). Pharmacokinetic/pharmacodynamic assessment of a proposed biosimilar MSB11455 versus the currently licensed pegfilgrastim: A randomized, double-blind trial. Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Chicago, IL, United States, 31May - 4 June, 2019. Alexandria, VA, United States: American Society of Clinical Oncology. doi: 10.1200/JCO.2019.37.15_suppl.e14514

RVT-1401, A Novel Anti-FcRn Monoclonal Antibody, Is Well Tolerated in Healthy Subjects and Reduces Plasma IgG Following Subcutaneous or Intravenous Administration

Collins, Jon, Jones, Lori, Snyder, Michele, Sicard, Eric, Griffin, Paul, Webster, Lindsey, Fong, Regan, Coquery, Christine and Piscitelli, Stephen (2019). RVT-1401, A Novel Anti-FcRn Monoclonal Antibody, Is Well Tolerated in Healthy Subjects and Reduces Plasma IgG Following Subcutaneous or Intravenous Administration. 71st Annual Meeting of the American Academy of Neurology (AAN), Philadelphia, PA, United States, 4-10 May, 2019. Philadelphia, PA, United States: Lippincott Williams & Wilkins.

A fitst-in-human study of BLZ-100 (tozuleristide) demonstrates tolerability and fluorescence contrast in skin cancer

Yamada, M., Miller, D., Lowe, M., Rowe, C., Wood, D., Byrnes-Blake, K., Parrish-Novak, J., Ishak, L., Olson, J., Brandt, G., Griffin, P., Spleman, L. and Prow, T. (2018). A fitst-in-human study of BLZ-100 (tozuleristide) demonstrates tolerability and fluorescence contrast in skin cancer. International Investigative Dermatology (IID) Meeting, Orlando, FL, United States, 16-19 May 2018. New York, United States: Elsevier.

First-in-human phase 1 safety study of BLZ-100 in subjects with skin cancer

Spelman, L., Johnston, J., Prow, T., Yamada, M., Griffin, P., Wood, D. and Miller, D. (2016). First-in-human phase 1 safety study of BLZ-100 in subjects with skin cancer. Australasian College of Dermatologists 49th Annual Scientific Meeting, Perth, Australia, 14–17 May 2016. HOBOKEN: WILEY-BLACKWELL.

A phase 1 evaluation of the pharmacokinetic/pharmacodynamics interaction of the antimalarial agent KAE609 and piperaquine (PPQ)

Stein, Daniel, Jain, Jay Prakash, Lickliter, Jason, Kangas, Michael, Machineri, Surendra and Griffin, Paul (2014). A phase 1 evaluation of the pharmacokinetic/pharmacodynamics interaction of the antimalarial agent KAE609 and piperaquine (PPQ). Challanges in malaria research: Core science and innovation, Oxford, United Kingdom, 22-24 September 2014. London, United Kingdom: BioMed Central. doi: 10.1186/1475-2875-13-S1-P85

Rapid Identification of Vancomycin Resistant Enterococci with Maldi-Tof Mass Spectrometry

Griffin, Paul, Price, Gareth, Hamilton, Brett, Schooneveldt, Jacqueline, Urbanski, Tess, Schlebusch, Sanmarie and Venter, Deon (2013). Rapid Identification of Vancomycin Resistant Enterococci with Maldi-Tof Mass Spectrometry. The Royal Australasian College of Physicians Future Directions in Health Congress 2013 (RACP), Perth, WA Australia, 26-29 May 2013. Richmond, VIC Australia: Wiley-Blackwell. doi: 10.1111/imj.12153

Rapid identification of VRE with MALDI-TOF MS

Griffin, Paul M., Price, Gareth R., Schooneveldt, Jacqueline M., Schlebusch, Sanmarié, Urbanski, Tess, Hamilton, Brett and Venter, Deon (2013). Rapid identification of VRE with MALDI-TOF MS. Australasian Division of the International Academy of Pathology 37th Annual Scientific Meeting 2012, Sydney, NSW Australia, 1-3 June 2012. London, United Kingdom: Elsevier. doi: 10.1097/01.pat.0000426852.32930.4a