The University of Queensland

Potential of β2AR for added benefit in treating heart failure through a better understanding of signaling

Walweel, Kafa, Cheesman, Elizabeth and Molenaar, Peter (2023). Potential of β2AR for added benefit in treating heart failure through a better understanding of signaling. Current Opinion in Physiology, 36 100719, 100719. doi: 10.1016/j.cophys.2023.100719

Donor heart ischemic time can be extended to 8 hours using hypothermic machine perfusion in sheep

See Hoe, Louise E., Bassi, Gianluigi Li, Wildi, Karin, Passmore, Margaret R., Bouquet, Mahe, Sato, Kei, Heinsar, Silver, Ainola, Carmen, Bartnikowski, Nicole, Wilson, Emily S., Hyslop, Kieran, Skeggs, Kris, Obonyo, Nchafatso G., Shuker, Tristan, Bradbury, Lucy, Palmieri, Chiara, Pedersen, Sanne-Engkilde, McDonald, Charles, Colombo, Sebastiano M., Wells, Matthew A., Reid, Janice D., O'Neill, Hollier, Livingstone, Samantha, Abbate, Gabriella, Haymet, Andrew, Jung, Jae-Seung, Sato, Noriko, James, Lynnette, He, Ting ... Fraser, John F. (2023). Donor heart ischemic time can be extended to 8 hours using hypothermic machine perfusion in sheep. The Journal of Heart and Lung Transplantation, 42 (8), 1015-1029. doi: 10.1016/j.healun.2023.03.020

Novel micro-computed tomography contrast agents to visualise the human cardiac conduction system and surrounding structures in hearts from normal, aged, and obese individuals: Iodine and graphene oxide – visualising human conduction system in normal, aged, and obese hearts

Aminu, Abimbola J., Chen, Weixuan, Yin, Zeyuan, Kuniewicz, Marcin, Walocha, Jerzy, Perde, Filip, Molenaar, Peter, Iaizzo, Paul A., Dobrzynski, Halina and Atkinson, Andrew J. (2022). Novel micro-computed tomography contrast agents to visualise the human cardiac conduction system and surrounding structures in hearts from normal, aged, and obese individuals: Iodine and graphene oxide – visualising human conduction system in normal, aged, and obese hearts. Translational Research in Anatomy, 27 100175, 1-17. doi: 10.1016/j.tria.2022.100175

A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death

See Hoe, Louise E., Wildi, Karin, Obonyo, Nchafatso G., Bartnikowski, Nicole, McDonald, Charles, Sato, Kei, Heinsar, Silver, Engkilde-Pedersen, Sanne, Diab, Sara, Passmore, Margaret R., Wells, Matthew A., Boon, Ai-Ching, Esguerra, Arlanna, Platts, David G., James, Lynnette, Bouquet, Mahe, Hyslop, Kieran, Shuker, Tristan, Ainola, Carmen, Colombo, Sebastiano M., Wilson, Emily S., Millar, Jonathan E., Malfertheiner, Maximillian V., Reid, Janice D., O’Neill, Hollier, Livingstone, Samantha, Abbate, Gabriella, Sato, Noriko, He, Ting ... Fraser, John F. (2021). A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death. Intensive Care Medicine Experimental, 9 (1) 60, 1-24. doi: 10.1186/s40635-021-00425-4

Further insights into the molecular complexity of the human sinus node – The role of ‘novel’ transcription factors and microRNAs

Aminu, Abimbola J., Petkova, Maria, Atkinson, Andrew J., Yanni, Joseph, Morris, Alex D., Simms, Robert T., Chen, Weixuan, Yin, Zeyuan, Kuniewicz, Marcin, Holda, Mateusz K., Kuzmin, Vladislav S., Perde, Filip, Molenaar, Peter and Dobrzynski, Halina (2021). Further insights into the molecular complexity of the human sinus node – The role of ‘novel’ transcription factors and microRNAs. Progress in Biophysics and Molecular Biology, 166, 86-104. doi: 10.1016/j.pbiomolbio.2021.04.008

Compromised right ventricular contractility in an ovine model of heart transplantation following 24 h donor brain stem death

Wells, Matthew A., See Hoe, Louise E., Molenaar, Peter, Pedersen, Sanne, Obonyo, Nchafatso G., McDonald, Charles I., Mo, Weilan, Bouquet, Mahè, Hyslop, Kieran, Passmore, Margaret R., Bartnikowski, Nicole, Suen, Jacky Y., Peart, Jason N., McGiffin, David C., Fraser, John F. and on behalf of the Dead Heart Project (2021). Compromised right ventricular contractility in an ovine model of heart transplantation following 24 h donor brain stem death. Pharmacological Research, 169 105631, 1-12. doi: 10.1016/j.phrs.2021.105631

Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (−)‐noradrenaline

Dashwood, Alexander, Cheesman, Elizabeth, Wong, Yee Weng, Haqqani, Haris, Beard, Nicole, Hay, Karen, Spratt, Melanie, Chan, Wandy and Molenaar, Peter (2021). Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (−)‐noradrenaline. Pharmacology Research and Perspectives, 9 (3) e00760, e00760. doi: 10.1002/prp2.760

Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk

Pineda, Santiago, Nikolova-Krstevski, Vesna, Leimena, Christiana, Atkinson, Andrew J., Altekoester, Ann-Kristin, Cox, Charles D., Jacoby, Arie, Huttner, Inken G., Ju, Yue-Kun, Soka, Magdalena, Ohanian, Monique, Trivedi, Gunjan, Kalvakuri, Sreehari, Birker, Katja, Johnson, Renee, Molenaar, Peter, Kuchar, Dennis, Allen, David G., Van Helden, Dirk F., Harvey, Richard P., Hill, Adam P., Bodmer, Rolf, Vogler, Georg, Dobrzynski, Halina, Ocorr, Karen and Fatkin, Diane (2021). Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk. Circulation: Genomic and Precision Medicine, 14 (2) 003144, 230-242. doi: 10.1161/CIRCGEN.120.003144

Correction to “Understanding How Phosphorylation and Redox Modifications Regulate Cardiac Ryanodine Receptor Type 2 Activity to Produce an Arrhythmogenic Phenotype in Advanced Heart Failure”

Dashwood, Alexander, Beard, Nicole, Wong, Yee Weng, Haqqani, Haris, Cheesman, Elizabeth and Molenaar, Peter (2020). Correction to “Understanding How Phosphorylation and Redox Modifications Regulate Cardiac Ryanodine Receptor Type 2 Activity to Produce an Arrhythmogenic Phenotype in Advanced Heart Failure”. ACS Pharmacology and Translational Science, 3 (6), 1422-1422. doi: 10.1021/acsptsci.0c00148

Sarcoplasmic reticulum calcium mishandling: central tenet in heart failure?

Denniss, Amanda L., Dashwood, Alexander M., Molenaar, Peter and Beard, Nicole A. (2020). Sarcoplasmic reticulum calcium mishandling: central tenet in heart failure?. Biophysical Reviews, 12 (4), 865-878. doi: 10.1007/s12551-020-00736-y

Understanding how phosphorylation and redox modifications regulate cardiac ryanodine receptor type 2 activity to produce an arrhythmogenic phenotype in advanced heart failure

Dashwood, Alexander, Cheesman, Elizabeth, Beard, Nicole, Haqqani, Haris, Wong, Yee Weng and Molenaar, Peter (2020). Understanding how phosphorylation and redox modifications regulate cardiac ryanodine receptor type 2 activity to produce an arrhythmogenic phenotype in advanced heart failure. ACS Pharmacology and Translational Science, 3 (4) acsptsci.0c00003, 563-582. doi: 10.1021/acsptsci.0c00003

Phenytoin reduces activity of cardiac ryanodine receptor 2; a potential mechanism for its cardioprotective action

Ashna, A., van Heiden, D. F., dos Remedios, C., Molenaar, P. and Laver, D. R. (2020). Phenytoin reduces activity of cardiac ryanodine receptor 2; a potential mechanism for its cardioprotective action. Molecular Pharmacology, 97 (4), 250-258. doi: 10.1124/mol.119.117721

Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814

Walweel, Kafa, Gomez-Hurtado, Nieves, Rebbeck, Robyn T., Oo, Ye Wint, Beard, Nicole A., Molenaar, Peter, dos Remedios, Cris, van Helden, Dirk F., Cornea, Razvan L., Knollmann, Björn C. and Laver, Derek R. (2019). Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814. Journal of Molecular and Cellular Cardiology, 130, 96-106. doi: 10.1016/j.yjmcc.2019.03.018

The β3-adrenoceptor agonist mirabegron increases human atrial force through β1-adrenoceptors: an indirect mechanism?

Mo, Weilan, Michel, Martin C., Lee, Xiang Wen, Kaumann, Alberto J. and Molenaar, Peter (2017). The β3-adrenoceptor agonist mirabegron increases human atrial force through β1-adrenoceptors: an indirect mechanism?. British Journal of Pharmacology, 174 (16), 2706-2715. doi: 10.1111/bph.13897

Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts

Walweel, K., Molenaar, P., Imtiaz, M. S., Denniss, A., dos Remedios, C., van Helden, D. F., Dulhunty, A. F., Laver, D. R. and Beard, N. A. (2017). Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts. Journal of Molecular and Cellular Cardiology, 104, 53-62. doi: 10.1016/j.yjmcc.2017.01.016

Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation

Foster, Simon R., Porrello, Enzo R., Stefani, Maurizio, Smith, Nicola J., Molenaar, Peter, Dos Remedios, Cristobal G., Thomas, Walter G. and Ramialison, Mirana (2015). Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation. Naunyn-Schmiedeberg's Archives of Pharmacology, 388 (10) 1118, 1009-1027. doi: 10.1007/s00210-015-1118-1

G protein-coupled receptors in cardiac biology: old and new receptors

Foster, Simon R, Roura, Eugeni, Molenaar, Peter and Thomas, Walter G. (2015). G protein-coupled receptors in cardiac biology: old and new receptors. Biophysical Reviews, 7 (1), 77-89. doi: 10.1007/s12551-014-0154-2

Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum

Walweel, Kafa, Li, Jiao, Molenaar, Peter, Imtiaz, Mohammad S., Quail, Anthony, dos Remedios, Cris G., Beard, Nicole A., Dulhunty, Angela F., van Helden, Dirk F. and Laver, Derek R. (2014). Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum. Journal of General Physiology, 144 (3), 263-271. doi: 10.1085/jgp.201311157

Carvedilol induces greater control of β2- than β1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium

Molenaar, Peter, Christ, Torsten, Berk, Emanuel, Engel, Andreas, Gillette, Katherine T., Galindo-Tovar, Alejandro, Ravens, Ursula and Kaumann, Alberto J. (2014). Carvedilol induces greater control of β2- than β1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium. Naunyn-Schmiedeberg's Archives of Pharmacology, 387 (7), 629-640. doi: 10.1007/s00210-014-0974-4

Chronic activation of the low affinity site of beta(1)-adrenoceptors stimulates haemodynamics but exacerbates pressure-overload cardiac remodelling

Kiriazis, Helen, Tugiono, Niquita, Xu, Qi, Gao, Xiao-Ming, Jennings, Nicole L., Ming, Ziqui, Su, Yidan, Klenowski, Paul, Summers, Roger J., Kaumann, Alberto, Molenaar, Peter and Du, Xiao-Jun (2013). Chronic activation of the low affinity site of beta(1)-adrenoceptors stimulates haemodynamics but exacerbates pressure-overload cardiac remodelling. British Journal of Pharmacology, 170 (2), 352-365. doi: 10.1111/bph.12272

PDE3, but not PDE4, reduces beta 1- and beta 2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients

Molenaar, Peter, Christ, Torsten, Hussain, Rizwan I., Engel, Andreas, Berk, Emanuel, Gillette, Katherine T., Chen, Lu, Galindo-Tovar, Alejandro, Krobert, Kurt A., Ravens, Ursula, Levy, Finn Olav and Kaumann, Alberto J. (2013). PDE3, but not PDE4, reduces beta 1- and beta 2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients. British Journal of Pharmacology, 169 (3), 528-538. doi: 10.1111/bph.12167

Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart

Foster, Simon R., Porrello, Enzo R., Purdue, Brooke, Chan, Hsiu-Wen, Voigt, Anja, Frenzel, Sabine, Hannan, Ross D., Moritz, Karen M., Simmons, David G., Molenaar, Peter, Roura, Eugeni, Boehm, Ulrich, Meyerhof, Wolfgang and Thomas, Walter G. (2013). Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart. PLoS ONE, 8 (5) e64579, e64579-1-e64579-10. doi: 10.1371/journal.pone.0064579

Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal area

Chandler, Natalie, Aslanidi, Oleg, Buckley, David, Inada, Shin, Birchall, Steven, Atkinson, Andrew, Kirk, Danielle, Monfredi, Oliver, Molenaar, Peter, Anderson, Robert, Sharma, Vinod, Sigg, Daniel, Zhang, Henggui, Boyett, Mark and Dobrzynski, Halina (2011). Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal area. Anatomical Record, 294 (6), 970-979. doi: 10.1002/ar.21379

Molecular architecture of the human specialised atrioventricular conduction axis

Greener, I. D., Monfredi, O., Inada, S., Chandler, N. J, Tellez, J.O., Atkinson, A., Taube, M. A., Billeter, R., Anderson, R. H., Efimov, I. R., Molenaar, P., Sigg, D. C., Sharma, V., Boyett, M. R. and Dobrzynski, H. (2011). Molecular architecture of the human specialised atrioventricular conduction axis. Journal of Molecular and Cellular Cardiology, 50 (4), 642-651. doi: 10.1016/j.yjmcc.2010.12.017

Human atrial β 1L-adrenoceptor but not β 3- adrenoceptor activation increases force and Ca 2+ current at physiological temperature

Christ, Torsten, Molenaar, Peter, Klenowski, Paul M., Ravens, Ursula and Kaumann, Alberto J. (2011). Human atrial β 1L-adrenoceptor but not β 3- adrenoceptor activation increases force and Ca 2+ current at physiological temperature. British Journal of Pharmacology, 162 (4), 823-839. doi: 10.1111/j.1476-5381.2010.00996.x

P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regions

Musa, Hanny, Tellez, James O., Chandler, Natalie J., Greener, Ian D., Maczewski, Michał, Mackiewicz, Urszula, Beresewicz, Andrzej, Molenaar, Peter, Boyett, Mark R. and Dobrzynski, Halina (2009). P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regions. Naunyn-Schmiedeberg's Archives of Pharmacology, 379 (6), 541-549. doi: 10.1007/s00210-009-0403-2

Molecular Architecture of the Human Sinus Node Insights Into the Function of the Cardiac Pacemaker

Chandler, Natalie J., Greener, Ian D., Tellez, James O., Inada, Shin, Musa, Hanny, Molenaar, Peter, DiFrancesco, Dario, Baruscotti, Mirko, Longhi, Renato, Anderson, Robert H., Billeter, Rudolf, Sharma, Vinod, Sigg, Daniel C., Boyett, Mark R. and Dobrzynski, Halina (2009). Molecular Architecture of the Human Sinus Node Insights Into the Function of the Cardiac Pacemaker. Circulation, 119 (12), 1562-1575. doi: 10.1161/CIRCULATIONAHA.108.804369

The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology

Kaumann, Alberto J. and Molenaar, Peter (2008). The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology. Pharmacology and Therapeutics, 118 (3), 303-336. doi: 10.1016/j.pharmthera.2008.03.009

Arg389Gly-beta(1)-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol

Cheng lu, Meyers, Deborah, Javorsky, George, Bursto, Darryl, Lolekha, Pakorn, Lucas, Margaret, Semmler, Annalese B. T., Savarimuthu, Santiyagu M., Fong, Kwun M., Yang, Ian A., Atherton, John, Galbraith, Andrew J., Parsonage, William A. and Molenaar, Peter (2007). Arg389Gly-beta(1)-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol. Pharmacogenetics And Genomics, 17 (11), 941-949. doi: 10.1097/FPC.0b013e3282ef7354

Human heart beta-adrenoceptors: beta(1)-adrenoceptor diversification through 'affinity states' and polymorphism

Molenaar, P., Chen, L., Semmler, A. B. T., Parsonage, W. A. and Kaumann, A. J. (2007). Human heart beta-adrenoceptors: beta(1)-adrenoceptor diversification through 'affinity states' and polymorphism. Clinical And Experimental Pharmacology And Physiology, 34 (10), 1020-1028. doi: 10.1111/j.1440-1681.2007.04730.x

beta(2)-adrenoceptor polymorphisms and obstructive airway diseases: Important issues of study design

Yang, Ian A., Ng, Taria, Molenaar, Peter and Fong, Kwun M. (2007). beta(2)-adrenoceptor polymorphisms and obstructive airway diseases: Important issues of study design. Clinical And Experimental Pharmacology and Physiology, 34 (10), 1029-1036. doi: 10.1111/j.1440-1681.2007.04731.x

The effects of both noradrenaline and CGP12177, mediated through human beta(1)-adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells

Kaumann, Alberto, Semmler, Annalese B. T. and Molenaar, Peter (2007). The effects of both noradrenaline and CGP12177, mediated through human beta(1)-adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells. Naunyn-schmiedebergs Archives of Pharmacology, 375 (2), 123-131. doi: 10.1007/s00210-007-0140-3

(-)Adrenaline elicits positive inotropic,lusitropic, and biochemical effects through ß2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consisten with Gs coupling but not with Gi coupling.

Molenaar, P., Savarimuthu, S. M., Sarsero, D., Chen, L., Semmler, A. B. T., Carle, A., Yang, I., Bartel, S., Vetter, D., Beyerdorfer, I., Krause,E-G. and Kaumann, A. J. (2007). (-)Adrenaline elicits positive inotropic,lusitropic, and biochemical effects through ß2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consisten with Gs coupling but not with Gi coupling.. Naunyn-Schmiedeberg's Archives of Pharmocolgy, 375 (1), 11-28. doi: 10.1007/s00210-007-0138-x

Cardiac implications for the use of beta(2)-adrenoceptor agonists for the management of muscle wasting

Molenaar, Peter, Chen, Lu and Parsonage, William A. (2006). Cardiac implications for the use of beta(2)-adrenoceptor agonists for the management of muscle wasting. British Journal of Pharmacology, 147 (6), 583-586. doi: 10.1038/sj.bjp.0706670

Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heart

Molenaar, Peter, Christ, Torsten, Ravens, Ursula and Kaumann, Alberto (2006). Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heart. Cardiovascular Research, 69 (1), 128-139. doi: 10.1016/j.cardiores.2005.08.024

Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II

Li, J., Wang, J. C., Russell, F. D. and Molenaar, P. (2005). Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II. British Journal of Pharmacology, 145 (4), 432-440. doi: 10.1038/sj.bjp.0706217

Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: Effects in human, rat and guinea-pig tissues in vitro and in pigs in vivo

Winkel, KD, Tibballs, J, Molenaar, P, Lambert, G, Coles, P, Ross-Smith, M, Wiltshire, C, Fenner, PJ, Gershwin, LA, Hawdon, GM, Wright, CE and Angus, JA (2005). Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: Effects in human, rat and guinea-pig tissues in vitro and in pigs in vivo. Clinical And Experimental Pharmacology And Physiology, 32 (9), 777-788. doi: 10.1111/j.1440-1681.2005.04258.x

Fundamental considerations of beta-adrenoceptor subtypes in human heart failure

Molenaar, P and Parsonage, WA (2005). Fundamental considerations of beta-adrenoceptor subtypes in human heart failure. Trends In Pharmacological Sciences, 26 (7), 368-375. doi: 10.1016/j.tips.2005.05.005

Cardiovascular actions of human urotensin II - considerations for hypertension

Russell, F. D. and Molenaar, P. (2004). Cardiovascular actions of human urotensin II - considerations for hypertension. Naunyn-Schmiedebergs Archives of Pharmacology, 369 (3), 271-273. doi: 10.1007/s00210-004-0876-y

Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure

Brattelid, T, Qvigstad, E, Lynham, JA, Molenaar, P, Aass, H, Geiran, O, Skomedal, T, Osnes, JB, Levy, FO and Kaumann, AJ (2004). Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure. Naunyn-Schmiedeberg's Arch Pharmacol, 370 (3), 157-166. doi: 10.1007/s00210-004-0963-0

Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart

Russell, FD and Molenaar, P (2004). Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart. Cardiovascular Research, 63 (4), 673-681. doi: 10.1016/j.cardiores.2004.05.009

Urotensin-II-converting enzyme activity of furin and trypsin in human cells in vitro

Russell, F. D., Kearns, P., Toth, I. and Molenaar, P. (2004). Urotensin-II-converting enzyme activity of furin and trypsin in human cells in vitro. Journal of Pharmacology And Experimental Therapeutics, 310 (1), 209-214. doi: 10.1124/jpet.104.065425

Intrinsic sympathomimetic activity of (-)-pindolol mediated through a (-)-propranolol-resistant site of the beta(1)-adrenoceptor in human atrium and recombinant receptors

Joseph, Shirin S., Lynham, James A., Molenaar, Peter, Grace, Andrew A., Colledge, William H. and Kaumann, Alberto J. (2003). Intrinsic sympathomimetic activity of (-)-pindolol mediated through a (-)-propranolol-resistant site of the beta(1)-adrenoceptor in human atrium and recombinant receptors. Naunyn-Schmiedeberg's Archives of Pharmacology, 368 (6), 496-503. doi: 10.1007/s00210-003-0835-z

(-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the beta1-adrenoceptor

Sarsero, Doreen, Russell, Fraser D., Lynham, James A., Rabnott, Glenn, Yang, Ian, Fong, Kwun M., Li, Li, Kaumann, Alberto J. and Molenaar, Peter (2003). (-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the beta1-adrenoceptor. Naunyn-Schmiedeberg's Archives of Pharmacology, 367 (1), 10-21. doi: 10.1007/s00210-002-0652-9

Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure

Russell, F. D., Meyers, D. E., Galbraith, A., Bett, N., Toth, I., Kearns, P. S. and Molenaar, P. (2003). Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure. American Journal of Physiology - Heart & Circulatory Physiology, 285 (Oct.2003), H1576-H1581. doi: 10.1152/ajpheart.00217.2003

The 'state' of beta-adrenoceptors

Molenaar, P. (2003). The 'state' of beta-adrenoceptors. British Journal of Pharmacology, 140 (1), 1-2. doi: 10.1038/sj.bjp.0705420

(-)-Pindolol acts through two states of the beta(1)-adrenoceptor in human atrium and CHO cells.

Kaumann, AJ, Lynham, JA, Joseph, SS, Colledge, WH, Grace, AA and Molenaar, P (2002). (-)-Pindolol acts through two states of the beta(1)-adrenoceptor in human atrium and CHO cells.. British Journal of Pharmacology, 135

Conservation of the cardiostimulant effects of (-)-Norepinephrine across Ser49Gly and Gly389Arg Beta1-adrenergic receptor polymorphisms in human right atrium in vitro

Molenaar, P., Rabnott, G., Yang, I., Fong, K. M., Savarimuthu, S. M., Li, L., West, M. J. and Russell, F. D. (2002). Conservation of the cardiostimulant effects of (-)-Norepinephrine across Ser49Gly and Gly389Arg Beta1-adrenergic receptor polymorphisms in human right atrium in vitro. Journal of The American College of Cardiology, 40 (7), 1275-1282. doi: 10.1016/S0735-1097(02)02137-X

Abolition of (-)-CGP 12177-evoked cardiostimulation in double beta(1)/beta(2)-adrenoceptor knockout mice. Obligatory role of beta(1)-adrenoceptors for putative beta 4-adrenoceptor pharmacology

Kaumann, AJ, Engelhardt, S, Hein, L, Molenaar, P and Lohse, M (2001). Abolition of (-)-CGP 12177-evoked cardiostimulation in double beta(1)/beta(2)-adrenoceptor knockout mice. Obligatory role of beta(1)-adrenoceptors for putative beta 4-adrenoceptor pharmacology. Naunyn-schmiedebergs Archives of Pharmacology, 363 (1), 87-93. doi: 10.1007/s002100000336

Cardiostimulant effects of urotensin-II in human heart in vitro

Russell, FD, Molenaar, P and O'Brien, DM (2001). Cardiostimulant effects of urotensin-II in human heart in vitro. British Journal of Pharmacology, 132 (1), 5-9. doi: 10.1038/sj.bjp.0703811

Murine ventricular L-type Ca2+ current is enhanced by zinterol via beta(1)-adrenoceptors, and is reduced in TG4 mice overexpressing the human beta(2)-adrenoceptor

Heubach, J. F., Graf, E. M., Molenaar, P., Jager, A., Schroder, F., Herzig, S., Harding, S. E. and Ravens, U. (2001). Murine ventricular L-type Ca2+ current is enhanced by zinterol via beta(1)-adrenoceptors, and is reduced in TG4 mice overexpressing the human beta(2)-adrenoceptor. British Journal of Pharmacology, 133 (1), 73-82. doi: 10.1038/sj.bjp.0704045

Both beta(2)- and beta(1)-adrenergic receptors mediate hastened relaxation and phosphorylation of phospholamban and troponin I in ventricular myocardium of fallot infants, consistent with selective coupling of beta(2)-adrenergic receptors to G(s)-protein

Molenaar, P., Bartel, S., Cochrane, A., Vetter, D., Jalali, H., Pohlner, P., Burrell, K., Karczewski, P, Krause, E. and Kaumann, A. J. (2000). Both beta(2)- and beta(1)-adrenergic receptors mediate hastened relaxation and phosphorylation of phospholamban and troponin I in ventricular myocardium of fallot infants, consistent with selective coupling of beta(2)-adrenergic receptors to G(s)-protein. Circulation, 102 (15), 1814-1821. doi: 10.1161/01.CIR.102.15.1814

Contribution of beta-adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wild-type and beta(3)-adrenoceptor knockout mice

Oostendorp, J., Preitner, F., Moffatt, J., Jimenez, M., Giacobino, J. P., Molenaar, P. and Kaumann, A. J. (2000). Contribution of beta-adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wild-type and beta(3)-adrenoceptor knockout mice. British Journal of Pharmacology, 130 (4), 747-758. doi: 10.1038/sj.bjp.0703365

Contractile and arrhythmic effects of endothelin receptor agonists in human heart in vitro: Blockade with SB 209670

Burrell, K. M., Molenaar, P., Dawson, P. J. and Kaumann, A. J. (2000). Contractile and arrhythmic effects of endothelin receptor agonists in human heart in vitro: Blockade with SB 209670. Journal of Pharmacology and Experimental Therapeutics, 292 (1), 449-459.

Quantitative analysis of vascular to cardiac selectivity of L- and T-type voltage-operated calcium channel antagonists in human tissues

Angus, J, Sarsero, D, Fujiwara, T, Molenaar, P and Xi, Q (2000). Quantitative analysis of vascular to cardiac selectivity of L- and T-type voltage-operated calcium channel antagonists in human tissues. Clinical And Experimental Pharmacology And Physiology, 27 (12), 1019-1021. doi: 10.1046/j.1440-1681.2000.03369.x

The human heart endothelin system: ET-1 synthesis, storage, release and effect

Russell, F. D. and Molenaar, P. (2000). The human heart endothelin system: ET-1 synthesis, storage, release and effect. Trends in Pharmacological Sciences, 21 (9), 353-359. doi: 10.1016/S0165-6147(00)01524-8

Activation of beta(2)-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failure

Kaumann, A, Bartel, S, Molenaar, P, Sanders, L, Burrell, K, Vetter, D, Hempel, P, Karczewski, P and Krause, EG (1999). Activation of beta(2)-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failure. Circulation, 99 (1), 65-72.

Putative beta(4)-adrenoceptors in rat ventricle mediate increases in contractile force and cell Ca2+: comparison with atrial receptors and relationship to (-)-[H-3]-CGP 12177 binding

Sarsero, D., Molenaar, P., Kaumann, A. J. and Freestone, N. S. (1999). Putative beta(4)-adrenoceptors in rat ventricle mediate increases in contractile force and cell Ca2+: comparison with atrial receptors and relationship to (-)-[H-3]-CGP 12177 binding. British Journal of Pharmacology, 128 (7), 1445-1460. doi: 10.1038/sj.bjp.0702936

Studies on a novel selective beta(3)-adrenoceptor agonist in human right atrial appendage and human white adipocytes

Arch, JRS, Kaumann, AJ, Molenaar, P, Sennitt, MV, Berge, JM, Chapman, H and Kelly, J (1999). Studies on a novel selective beta(3)-adrenoceptor agonist in human right atrial appendage and human white adipocytes. British Journal of Pharmacology, 126, U55-U55.

Validity of (-)-[H-3]-CGP 12177A as a radioligand for the 'putative beta(4)-adrenoceptor' in rat atrium

Sarsero, Doreen, Molenaar, Peter and Kaumann, Alberto J. (1998). Validity of (-)-[H-3]-CGP 12177A as a radioligand for the 'putative beta(4)-adrenoceptor' in rat atrium. British Journal of Pharmacology, 123 (3), 371-380. doi: 10.1038/sj.bjp.0701609

(-)-CGP 12177 causes cardiostimulation and binds to cardiac putative beta(4)-adrenoceptors in both wild-type and beta(3)-adrenoceptor knockout mice

Kaumann, AJ, Preitner, F, Sarsero, D, Molenaar, P, Revelli, JP and Giacobino, JP (1998). (-)-CGP 12177 causes cardiostimulation and binds to cardiac putative beta(4)-adrenoceptors in both wild-type and beta(3)-adrenoceptor knockout mice. Molecular Pharmacology, 53 (4), 670-675.

(-)-[H-3]-CGP 12177 radiolabels beta(1)-, beta(2)- and putative beta(4)-adrenoceptors in human atrium and ventricle.

Sarsero, D, Molenaar, P and Kaumann, AJ (1998). (-)-[H-3]-CGP 12177 radiolabels beta(1)-, beta(2)- and putative beta(4)-adrenoceptors in human atrium and ventricle.. Naunyn-schmiedebergs Archives of Pharmacology, 358 (1), R629-R629.

Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists

Sarsero, D, Fujiwara, T, Molenaar, P and Angus, JA (1998). Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists. British Journal of Pharmacology, 125 (1), 109-119. doi: 10.1038/sj.bjp.0702045

Inotropic and arrhythmic effects of endothelin receptor agonists in human heart: Possible involvement of multiple receptors, L-type calcium channels and Gi-protein.

Burrell, KM, Molenaar, P and Kaumann, AJ (1998). Inotropic and arrhythmic effects of endothelin receptor agonists in human heart: Possible involvement of multiple receptors, L-type calcium channels and Gi-protein.. Naunyn-schmiedebergs Archives of Pharmacology, 358 (1), R627-R627.

The contribution of classical (beta(1/2)-) and atypical beta-adrenoceptors to the stimulation of human white adipocyte lipolysis and right atrial appendage contraction by novel beta(3)-adrenoceptor agonists of differing selectivities

Molenaar, P (1998). The contribution of classical (beta(1/2)-) and atypical beta-adrenoceptors to the stimulation of human white adipocyte lipolysis and right atrial appendage contraction by novel beta(3)-adrenoceptor agonists of differing selectivities. Journal of Pharmacology And Experimental Therapeutics, 285 (3), 1084-1095.

The putative beta(4)-adrenoceptor activates the cyclic AMP pathway in human heart: Inhibition of positive inotropic responses by adenosine and carbachol

Molenaar, P, Sarsero, D, Lynham, JA and Kaumann, AJ (1998). The putative beta(4)-adrenoceptor activates the cyclic AMP pathway in human heart: Inhibition of positive inotropic responses by adenosine and carbachol. Naunyn-schmiedebergs Archives of Pharmacology, 358 (1), R629-R629.

Effects of (-)-RO363 at human atrial beta-adrenoceptor subtypes, the human cloned beta(3)-adrenoceptor and rodent intestinal beta(3)-adrenoceptors

Molenaar, P, Sarsero, D, Arch, JRS, Kelly, J, Henson, SM and Kaumann, AJ (1997). Effects of (-)-RO363 at human atrial beta-adrenoceptor subtypes, the human cloned beta(3)-adrenoceptor and rodent intestinal beta(3)-adrenoceptors. British Journal of Pharmacology, 120 (2), 165-176. doi: 10.1038/sj.bjp.0700850

Modulation of human cardiac function through 4 beta-adrenoceptor populations

Kaumann, AJ and Molenaar, P (1997). Modulation of human cardiac function through 4 beta-adrenoceptor populations. Naunyn-schmiedebergs Archives of Pharmacology, 355 (6), 667-681. doi: 10.1007/PL00004999

On criteria for functional beta(3)-adrenoceptors

Molenaar, P and Kaumann, AJ (1997). On criteria for functional beta(3)-adrenoceptors. Trends In Pharmacological Sciences, 18 (7), 258-258. doi: 10.1016/S0165-6147(97)90635-0

Proposal for the interaction of non-conventional partial agonists and catecholamines with the 'putative beta(4)-adrenoceptor' in mammalian heart

Molenaar, P, Sarsero, D and Kaumann, AJ (1997). Proposal for the interaction of non-conventional partial agonists and catecholamines with the 'putative beta(4)-adrenoceptor' in mammalian heart. Clinical And Experimental Pharmacology And Physiology, 24 (9-10), 647-656. doi: 10.1111/j.1440-1681.1997.tb02107.x

The atypical cardiostimulant beta-adrenoceptor is distinct from beta-adrenoceptors and coupled to a cyclic AMP-dependent pathway in human and rat myocardium

Kaumann, AJ, Lynham, JA, Sarsero, D and Molenaar, P (1997). The atypical cardiostimulant beta-adrenoceptor is distinct from beta-adrenoceptors and coupled to a cyclic AMP-dependent pathway in human and rat myocardium. British Journal of Pharmacology, 120, P102-P102.

Antiarrhythmic Effects of Phenytoin, a Novel Heart Failure Diastolic Ryanodine Channel Inhibitor, in Human Failing Ventricle

Spratt, M., Dashwood, A., Cheesman, E., Haqqani, H., Wong, Y., Chan, W., Laver, D. and Molenaar, P. (2022). Antiarrhythmic Effects of Phenytoin, a Novel Heart Failure Diastolic Ryanodine Channel Inhibitor, in Human Failing Ventricle. 70th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Gold Coast, QLD Australia, 11-14 August 2022. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2022.06.062

Post-transplant cardiac contractility and mitochondrial function is preserved following 8 hours hypothermic ex vivo perfusion in sheep

See Hoe, L., Bouquet, M., Hyslop, K., Passmore, M., Wells, M., Sato, K., Wilson, E., Wildi, K., Skeggs, K., Palmeri, C., Reid, J., O'Neill, H., Bartnikowski, N., Jung, J., Ainola, C., Abbate, G., Colombo, S., Obonyo, N., McDonald, C., Shuker, T., Heinsar, S., Haymet, A., Engkilde-Pedersen, S., Peart, J., Molenaar, P., Li Bassi, G., Suen, J., McGiffin, D. and Fraser, J. (2022). Post-transplant cardiac contractility and mitochondrial function is preserved following 8 hours hypothermic ex vivo perfusion in sheep. 70th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Gold Coast, QLD, Australia, 11-14 August 2022. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2022.06.547

Development of an ovine model of heart transplantation following 24-hour brain stem death

See Hoe, L., Engkilde-Pedersen, S., Obonyo, N., Wells, M., Boon, C., Bartnikowski, N., Passmore, M., McDonald, C., Black, D., Molenaar, P., Diab, S., Suen, J., Marasco, S., McGiffin, D. and Fraser, J. (2018). Development of an ovine model of heart transplantation following 24-hour brain stem death. 66th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 12th Annual Australia and New Zealand Endovascular Therapies Meeting, Brisbane, Australia, 2-5 August 2018. Chatswood, NSW, Australia: Elsevier . doi: 10.1016/j.hlc.2018.06.111

Transcriptional Regulation of Taste Receptor Genes: Novel Insights From In Silico and Cardiac Gene Expression Analyses

Foster, Simon R., Porrello, Enzo R., Stefani, Maurizio, Smith, Nicola J., Molenaar, Peter, dos Remedios, Cris G., Thomas, Walter G. and Ramialison, Mirana (2015). Transcriptional Regulation of Taste Receptor Genes: Novel Insights From In Silico and Cardiac Gene Expression Analyses. 15th Scientific Meeting of the Australasian Association for ChemoSensory Science (AACSS), Brisbane, QLD Australia, 03-05 December 2014. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/chemse/bjv008

The role of beta1 adrenoceptors in the development of alcohol dependence

Klenowski, P. M., Holgate, J., Bellingham, M., Molenaar, P. and Bartlett, S. (2013). The role of beta1 adrenoceptors in the development of alcohol dependence. Neuroscience 2013: 43rd Annual Meeting of the Society for Neuroscience, San Diego, CA, USA, 9-13 November, 2013.

Beta1-adrenoceptor (AR) Arg389Gly polymorphisms affect responses to carvedilol in patients with idiopathic dilated cardiomyopathy

Chen, L., Meyers, D., Semmler, A.B., Yang, I., Pakorn, L., Lucas, M., Jovarsky, G., Savarimuthu, S., Galbraith, A., Parsonage, W. and Molenaar, P. (2006). Beta1-adrenoceptor (AR) Arg389Gly polymorphisms affect responses to carvedilol in patients with idiopathic dilated cardiomyopathy. 15th World Congress of Pharmacology, Beijing, China, 2nd - 7th July, 2006. China: Chinese Pharmacological Society.

Carvedilol causes a greater increase in heart function in idiopathic dilated cardiomyopathy patients with ARG389-compared to GLY389 Beta1-adrenoceptors

Molenaar, P., Chen, Lu, Meyers, E., Javorsky, G., Burstow, M., Lucas, P., Lolekha, J., Atherton, A., Semmler, A. B., Savarimuthu, S., Fong, K. M., Yang, I. A., Galbraith, A. and Parsonage, W. A. (2006). Carvedilol causes a greater increase in heart function in idiopathic dilated cardiomyopathy patients with ARG389-compared to GLY389 Beta1-adrenoceptors. The Australian Health and Medical Research Congress, Melbourn, Australia, 26th November - 1st December, 2006. Australia: Australian Govenment NHMRC.

Contractile responses through Gs-coupled receptors are reduced by phosphodiesterase3 activity in human isolated myocardium

Christ, T., Molenaar, P., Galindo-Tovar, A., Ravens, U. and Kaumann, A. J. (2006). Contractile responses through Gs-coupled receptors are reduced by phosphodiesterase3 activity in human isolated myocardium. Compartmentalization of cyclic AMP signalling, Cambridge, U.K., 29-30 March, 2006.

Human heart Beta-adrenoceptors:-Beta1-adrenoceptor diversification through 'affinity states' and polymorphism

Molenaar, P., Chen, Lu, Semmler, A. B., Parsonage, W. A. and Kaumann, A. (2006). Human heart Beta-adrenoceptors:-Beta1-adrenoceptor diversification through 'affinity states' and polymorphism. The Australian Health & Medical Research Congress, Melbourne, Australia, 26 November - 1 December, 2006. Australia: Australian Govenment NHMRC.

Human heart beta1-adrenoceptor heterogeneity - diversification through 'affinity states' and polymorphism

Molenaar, P., Chen, L., Semmler, A. B., Parsonage, W. A. and Kaumann, A. (2006). Human heart beta1-adrenoceptor heterogeneity - diversification through 'affinity states' and polymorphism. 15th World Congress of Pharmacology, Beijing, China, 7 - 9 July, 2006. China: Institute of Vascular Medicine.

Carvedilol blocks beta2- more than beta1-adrenoceptors in human heart

Molenaar, P., Christ, T., Ravens, U., Chen, L. and Kaumann, A. (2005). Carvedilol blocks beta2- more than beta1-adrenoceptors in human heart. Joint Meeting of ASCEPT & APSA, Melbourne, Australia, 4 - 7 Dec, 2005. Australia: ASCEPT.

Carvedilol blocks beta2-adrenoceptors more than beta1-adrenoceptors in human atrium

Kaumann, A. J. and Molenaar, P. (2005). Carvedilol blocks beta2-adrenoceptors more than beta1-adrenoceptors in human atrium. BPS Summer Meeting 2005, Cambridge, U.K., July, 2005.

Carvedilol causes greater persistent blockage of beta2- than beta1-adrenoceptors in human failing myocardium

Kaumann, A. J., Christ, T., Ravens, U. and Molenaar, P. (2005). Carvedilol causes greater persistent blockage of beta2- than beta1-adrenoceptors in human failing myocardium. BPS Summer Meeting 2005, Cambridge, U.K., July, 2005.

Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failure

Qvigstad, E., Brattelid, T., Sjaastad, I., Molenaar, P., Birkeland, J. A., Andressen, K. W., Krobert, K. A., Sejersted, O. M., Skomedal, T., Osnes, J-B., Kaumann, A. J. and Levy, F. O. (2005). Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failure. International Soc for Heart Research, European Section Mtg, Norway, 21-25 Jun, 2005. Italy: Medimond International.

Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin

Li, J., Wang, J., Russell, F. D. and Molenaar, P. (2004). Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin. 2004 ISHR World Congress Meeting, Brisbane, Qld, Australia, 7-11 Aug, 2004. United Kingdom: Academic Press.

Both 1- and 2-adrenoceptors mediate increases in contractile force and hastening of relaxation in human atrium

Krause, E.-G., Bartel, S., Vetter, D., Karczewski, P., Russell, F. D., Kaumann, A. J. and Molenaar, P. (2004). Both 1- and 2-adrenoceptors mediate increases in contractile force and hastening of relaxation in human atrium. 2004 ISHR World Congress Meeting, Brisbane, Qld, Australia, 7 - 11 August, 2004. United Kingdom: Academic Press. doi: 10.1016/j.yjmcc.2004.05.003

Investigation of urotensin-II converting enzyme activity in human cells and blood

Kearns, P., Russell, F. D., Toth, I. and Molenaar, P. (2004). Investigation of urotensin-II converting enzyme activity in human cells and blood. 8th Annual Scientific Sessions of the Latin American Section of the International-Society for Heart Research, Brisbane, Qld, Australia, 7th - 11th August, 2004. United Kingdom: Academic Press. doi: 10.1016/j.yjmcc.2004.05.003

Regulatory myosin light chain signaling pathways in urotensin-II-mediated positive inotropic effect in human right atrium

Russell, F. D. and Molenaar, P. (2004). Regulatory myosin light chain signaling pathways in urotensin-II-mediated positive inotropic effect in human right atrium. 2004 ISHR World Congress Meeting, Brisbane, Qld, Australia, 7 - 11 August, 2004. London, England: Academic Press. doi: 10.1016/j.yjmcc.2004.05.003

Activation of calcineurin in explanted human ventricle by endogenous peptides

Li, J., Russell, F. D. and Molenaar, P. (2003). Activation of calcineurin in explanted human ventricle by endogenous peptides. ASCEPT, Sydney, 30 Nov - 3 Dec, 2003. Australia: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists.

Intrinsic sympathomimetic activity (ISA) of (-)-pindolol mediated through a (-)-propranolol-resistant site of the beta1-adrenoceptor in human right atrium

Molenaar, P. and Kaumann, A. J. (2003). Intrinsic sympathomimetic activity (ISA) of (-)-pindolol mediated through a (-)-propranolol-resistant site of the beta1-adrenoceptor in human right atrium. ASCEPT, Sydney, 30 Nov - 3 Dec, 2003. Australia: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists.

Regulatory myosin light chain signaling pathways in urotensin-II-mediated positive inotropic effect in human right atrium

Russell, F. D. and Molenaar, P. (2003). Regulatory myosin light chain signaling pathways in urotensin-II-mediated positive inotropic effect in human right atrium. ASCEPT, Sydney, 30 Nov - 3 Dec, 2003. Australia: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists.

The positive inotropic effects of norepinephrine are potentiated by chronic beta1-blocker administration but are conserved across Ser49Gly- and Gly389Arg-beta1-adrenergic receptor polymorphisms in human right atrium

Molenaar, P., Russell, F. D., Rabnott, G., Yang, I., Fong, K. M., Savarimuthu, S. M., Li, L. and West, M. J. (2002). The positive inotropic effects of norepinephrine are potentiated by chronic beta1-blocker administration but are conserved across Ser49Gly- and Gly389Arg-beta1-adrenergic receptor polymorphisms in human right atrium. American Heart Association Scientific Sessions 2002, Chicago, 17-20 Nov, 2002. Hagerstown, U.S.A.: Lippincott Williams & Wilkins.

(-)-CGP 12177-evoked cardiostimulation is abolished in double b1-/b2-adrenoceptor (AR) knockout mice.

Kaumann, A. J., Engelhardt, S., Molenaar, P. and Lohse, M. (2000). (-)-CGP 12177-evoked cardiostimulation is abolished in double b1-/b2-adrenoceptor (AR) knockout mice.. Joint Meeting of ASCEPT and the British Pharmacological Society, Newcastle, Australia, 03-06 Dec, 2000. Sydney: Aust Society of Clin and Exp Pharmacologists and Toxicologists.

Cardiostimulant effects of human urotensin-II in human heart.

Russell, F. D., Molenaar, P. and O'Brien, D. M. (2000). Cardiostimulant effects of human urotensin-II in human heart.. Joint Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and the British Pharmacological Society, Newcastle, Australia, 03-06 Dec, 2000. Sydney: Aust Society of Clin & Exp Pharmacologists & Toxicologists.

Endogenous modulators of human heart contractility

Molenaar, P., Russell, F. D. and Burrell, K. (2000). Endogenous modulators of human heart contractility. ISHR Melbourne Conference 2000: Benchtop Bedside the Beside, Melbourne, Australia, 05-09 Aug, 2000. Melbourne: International Society for Heart Research (Australasian Section).

b1-, b2- and putative b4-adrenoceptors (AR) in adult and infant human heart: selective coupling of b2-AR to Gs-protein.

Molenaar, P. and Kaumann, A. J. (2000). b1-, b2- and putative b4-adrenoceptors (AR) in adult and infant human heart: selective coupling of b2-AR to Gs-protein.. Joint Meeting of ASCEPT and the British Pharmacological Society, Newcastle, Australia, 03-06 Dec, 2000. Sydney: Aust Society of Clin. and Exp. Pharmacologists & Toxicologists.

Contribution of b-adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wild-type and b3-adrenoceptor knockout mice: Involvement of the putative b4-adrenoceptor

Molenaar, P., Oostendorp, J., Preitner, F., Moffat, J., Jimenez, M., Giacobino, J. P. and Kaumann, A. J. (1999). Contribution of b-adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wild-type and b3-adrenoceptor knockout mice: Involvement of the putative b4-adrenoceptor. 33rd Annual Scientific Meeting of ASCEPT, Sydney Convention & Exhibition Cen., Darling Harbour, 4 - 8 Dec, 1999. Sydney: Aust. Soc. of Clinical & Experimental Pharm. & Toxicol..

Proceedings of the Australian Society for Medical Research

P. Molenaar, F. D. Russell, G. C. Rabnott, I. Yang, K. M. Fong and M. J. West eds. (2001). Proceedings of the Australian Society for Medical Research. BioInnovation: The Future of Medical Research, Gold Coast, Queensland, Australia, 24 - 27 November, 2001. Australia: Australian Society for Medical Research.