The University of Queensland

Cyclizing disulfide-rich peptides using sortase A

Agwa, Akello J., Craik, David J. and Schroeder, Christina I. (2019). Cyclizing disulfide-rich peptides using sortase A. In (pp. 29-41) : Humana Press Inc.. doi:10.1007/978-1-4939-9546-2_3

Block of voltage-gated calcium channels by peptide toxins

Schroeder, C. I., Lewis, R. J. and Adams, D. J. (2005). Block of voltage-gated calcium channels by peptide toxins. In Gerald W. Zamponi (Ed.), Voltage-Gated Calcium Channels (pp. 294-308) New York, U.S.A.: Springer US. doi:10.1007/0-387-27526-6_19

Anti-allodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute post-surgical pain: evidence for analgesic synergy with opioids and baclofen

Mueller, Alexander, Starobova, Hana, Morgan, Michael, Dekan, Zoltan, Cheneval, Olivier, Schroeder, Christina I., Alewood, Paul F., Deuis, Jennifer R. and Vetter, Irina (2019) Anti-allodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute post-surgical pain: evidence for analgesic synergy with opioids and baclofen. Pain, . doi:10.1097/j.pain.0000000000001567

Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors

Peigneur, Steve, Cheneval, Olivier, Maiti, Mohitosh, Leipold, Enrico, Heinemann, Stefan H., Lescrinier, Eveline, Herdewijn, Piet, De Lima, Maria Elena, Craik, David J., Schroeder, Christina I. and Tytgat, Jan (2019) Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors. FASEB Journal, 33 3: 3693-3703. doi:10.1096/fj.201801909R

Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1

Lawrence, Nicole, Wu, Bin, Ligutti, Joseph, Cheneval, Olivier, Agwa, Akello Joanna, Benfield, Aurélie H., Biswas, Kaustav, Craik, David J., Miranda, Les P., Henriques, Sónia Troeira and Schroeder, Christina I. (2018) Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1. ACS Chemical Biology, . doi:10.1021/acschembio.8b00989

Targeted delivery of cyclotides via conjugation to a nanobody

Kwon, Soohyun, Duarte, Joao N., Li, Zeyang, Ling, Jingjing J., Cheneval, Olivier, Durek, Thomas, Schroeder, Christina I., Craik, David J. and Ploegh, Hidde L. (2018) Targeted delivery of cyclotides via conjugation to a nanobody. ACS Chemical Biology, 13 10: 2973-2980. doi:10.1021/acschembio.8b00653

Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase a to form double-knottins that probe voltage-gated sodium channel NaV1.7

Agwa, Akello J., Blomster, Linda V., Craik, David J., King, Glenn F. and Schroeder, Christina I. (2018) Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase a to form double-knottins that probe voltage-gated sodium channel NaV1.7. Bioconjugate Chemistry, 29 10: 3309-3319. doi:10.1021/acs.bioconjchem.8b00505

Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1

de Veer, Simon J., Li, Choi Yi, Swedberg, Joakim E., Schroeder, Christina I. and Craik, David J. (2018) Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1. European Journal of Medicinal Chemistry, 155 695-704. doi:10.1016/j.ejmech.2018.06.029

Calcium-mediated allostery of the EGF fold

Wang, Conan K., Ghani, Hafiza Abdul, Bundock, Anna, Weidmann, Joachim, Harvey, Peta J., Edwards, Ingrid A., Schroeder, Christina I., Swedberg, Joakim E. and Craik, David J. (2018) Calcium-mediated allostery of the EGF fold. ACS Chemical Biology, 13 6: 1659-1667. doi:10.1021/acschembio.8b00291

Gating modifier toxins isolated from spider venom: modulation of voltage-gated sodium channels and the role of lipid membranes

Agwa, Akello J., Peigneur, Steve, Chow, Chun Yuen, Lawrence, Nicole, Craik, David J., Tytgat, Jan, King, Glenn F., Henriques, Sonia Troeira and Schroeder, Christina I. (2018) Gating modifier toxins isolated from spider venom: modulation of voltage-gated sodium channels and the role of lipid membranes. Journal of Biological Chemistry, 293 23: 9041-9052. doi:10.1074/jbc.RA118.002553

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1

Durek, Thomas, Cromm, Philipp M., White, Andrew M., Schroeder, Christina I., Kaas, Quentin, Weidmann, Joachim, Ahmad Fuaad, Abdullah, Cheneval, Olivier, Harvey, Peta J., Daly, Norelle L., Zhou, Yang, Dellsén, Anita, Österlund, Torben, Larsson, Niklas, Knerr, Laurent, Bauer, Udo, Kessler, Horst, Cai, Minying, Hruby, Victor J., Plowright, Alleyn T. and Craik, David J. (2018) Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1. Journal of Medicinal Chemistry, 61 8: 3674-3684. doi:10.1021/acs.jmedchem.8b00170

Bioactive compounds isolated from neglected predatory marine gastropods

Turner, Ashlin H., Craik, David J., Kaas, Quentin and Schroeder, Christina I. (2018) Bioactive compounds isolated from neglected predatory marine gastropods. Marine Drugs, 16 4: 118. doi:10.3390/md16040118

Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNa(V)1.7 (vol 1859, pg 835, 2017)

Agwa, Akello J., Lawrence, Nicole, Deplazes, Evelyne, Cheneval, Olivier, Chen, Rachel M., Craik, David J., Schroeder, Christina I. and Henriques, Sonia T. (2017) Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNa(V)1.7 (vol 1859, pg 835, 2017). Biochimica Et Biophysica Acta-Biomembranes, 1859 11: 2277-2277. doi:10.1016/j.bbamem.2017.08.008

Lengths of the C-terminus and interconnecting loops impact stability of spider-derived gating modifier toxins

Agwa, Akello J., Huang, Yen-Hua, Craik, David J., Henriques, Sonia T. and Schroeder, Christina I. (2017) Lengths of the C-terminus and interconnecting loops impact stability of spider-derived gating modifier toxins. Toxins, 9 8: 248. doi:10.3390/toxins9080248

Modelling the interactions between animal venom peptides and membrane proteins

Hung, Andrew, Kuyucak, Serdar, Schroeder, Christina I. and Kaas, Quentin (2017) Modelling the interactions between animal venom peptides and membrane proteins. Neuropharmacology, 127 20-31. doi:10.1016/j.neuropharm.2017.07.036

Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7

Agwa, Akello J., Lawrence, Nicole, Deplazes, Evelyne, Cheneval, Olivier, Chen, Rachel M., Craik, David J., Schroeder, Christina I. and Henriques, Sónia T. (2017) Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7. Biochimica et Biophysica Acta. Biomembranes, 1859 5: 835-844. doi:10.1016/j.bbamem.2017.01.020

Gating modifier toxin interactions with ion channels and lipid bilayers: Is the trimolecular complex real?

Agwa, Akello J., Henriques, Sónia T. and Schroeder, Christina I. (2017) Gating modifier toxin interactions with ion channels and lipid bilayers: Is the trimolecular complex real?. Neuropharmacology, 127 32-45. doi:10.1016/j.neuropharm.2017.04.004

Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies

Abdul Ghani, Hafiza, Henriques, Sonia Troeira, Huang, Yen-Hua, Swedberg, Joakim E. , Schroeder, Christina I. and Craik, David J. (2017) Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies. Biopolymers, 108 1: . doi:10.1002/bip.22927

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

Kwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I. and Craik, David J. (2016) Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering, 113 10: 2202-2212. doi:10.1002/bit.25993

Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1.7

Troeira Henriques, Sonia, Deplazes, Evelyne, Lawrence, Nicole, Cheneval, Olivier, Chaousis, Stephanie, Inserra, Marco, Thongyoo, Panumart, King, Glenn F., Mark, Alan E., Vetter, Irina, Craik, David J. and Schroeder, Christina Ingrid (2016) Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1.7. The Journal of Biological Chemistry, 291 33: 17049-17065. doi:10.1074/jbc.M116.729095

Substrate-guided design of selective FXIIa inhibitors based on the plant-derived Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold

Swedberg, Joakim E., Mahatmanto, Tunjung, Ghani, Hafiza Abdul, de Veer, Simon J., Schroeder, Christina I., Harris, Jonathan M. and Craik, David J. (2016) Substrate-guided design of selective FXIIa inhibitors based on the plant-derived Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold. Journal of Medicinal Chemistry, 59 15: 7287-7292. doi:10.1021/acs.jmedchem.6b00557

Truncated glucagon-like peptide-1 and exendin-4 α-conotoxin pl14a peptide chimeras maintain potency and α-helicity and reveal interactions vital for cAMP signaling in vitro

Swedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Price, David A., Liras, Spiros and Craik, David J. (2016) Truncated glucagon-like peptide-1 and exendin-4 α-conotoxin pl14a peptide chimeras maintain potency and α-helicity and reveal interactions vital for cAMP signaling in vitro. Journal of Biological Chemistry, 291 30: 15778-15787. doi:10.1074/jbc.M116.724542

Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8

Deuis, Jennifer R, Dekan, Zoltan, Inserra, Marco C., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Craik, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Schroeder, Christina I., Henriques, Sónia Troeira and Vetter, Irina (2016) Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8. Journal of Biological Chemistry, 291 22: 11829-11842. doi:10.1074/jbc.M116.721662

Membrane-binding properties of gating modifier and pore-blocking toxins: membrane interaction is not a prerequisite for modification of channel gating

Deplazes, Evelyne, Troeira Henriques, Sonia, Smith, Jennifer J., King, Glenn F., Craik, David J., Mark, Alan E. and Schroeder, Christina I. (2016) Membrane-binding properties of gating modifier and pore-blocking toxins: membrane interaction is not a prerequisite for modification of channel gating. Biochimica et Biophysica Acta - Biomembranes, 1858 4: 872-882. doi:10.1016/j.bbamem.2016.02.002

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization

Conibear, Anne C., Chaousis, Stephanie, Durek, Thomas, Rosengren, K. Johan, Craik, David J. and Schroeder, Christina I. (2016) Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization. Biopolymers, 106 1: 89-100. doi:10.1002/bip.22767

Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists

Swedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Durek, Thomas, Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Liras, Spiros, Price, David A. and Craik, David J. (2015) Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists. European Journal of Medicinal Chemistry, 103 175-184. doi:10.1016/j.ejmech.2015.08.046

Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients

Wang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David, A., Fairlie, David and Craik, David J. (2014) Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 111 49: 17504-17509. doi:10.1073/pnas.1417611111

Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed

Hill, Timothy A., Lohman, Rink-Jan, Hoang, Huy N., Nielsen, Daniel S., Scully, Conor C. G., Kok, W. Mei, Liu, Ligong, Lucke, Andrew J., Stoermer, Martin J., Schroeder, Christina I., Chaousis, Stephanie, Colless, Barbara, Bernhardt, Paul V., Edmonds, David J., Griffith, David A., Rotter, Charles J., Ruggeri, Roger B., Price, David A., Liras, Spiros, Craik, David J. and Fairlie, David P. (2014) Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed. ACS Medicinal Chemistry Letters, 5 10: 1148-1151. doi:10.1021/ml5002823

Fmoc-based synthesis of disulfide-rich cyclic peptides

Cheneval, Olivier, Schroeder, Christina I., Durek, Thomas, Walsh, Phillip, Huang, Yen-Hua, Liras, Spiros, Price, David A. and Craik, David J. (2014) Fmoc-based synthesis of disulfide-rich cyclic peptides. Journal of Organic Chemistry, 79 12: 5538-5544. doi:10.1021/jo500699m

High-throughput synthesis of peptide alpha-thioesters: a safety catch linker approach enabling parallel hydrogen fluoride cleavage

Brust, Andreas, Schroeder, Christina I. and Alewood, Paul F. (2014) High-throughput synthesis of peptide alpha-thioesters: a safety catch linker approach enabling parallel hydrogen fluoride cleavage. ChemMedChem, 9 5: 1038-1046. doi:10.1002/cmdc.201300524

Disulfide-rich macrocyclic peptides as templates in drug design

Northfield, Susan E., Wang, Conan K., Schroeder, Christina I., Durek, Thomas, Kan, Meng-Wei, Swedberg, Joakim E. and Craik, David J. (2014) Disulfide-rich macrocyclic peptides as templates in drug design. European Journal of Medicinal Chemistry, 77 2: 248-257. doi:10.1016/j.ejmech.2014.03.011

Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro

Schroeder, Christina I., Swedberg, Joakim E., Withka, Jane M., Rosengren, K. Johan, Akcan, Muharrem, Clayton, Daniel J., Daly, Norelle L., Cheneval, Olivier, Borzilleri, Kris A., Griffor, Matt, Stock, Ingrid, Colless, Barbara, Walsh, Phillip, Sunderland, Phillip, Reyes, Allan, Dullea, Robert, Ammirati, Mark, Liu, Shenping, McClure, Kim F., Tu, Meihua, Bhattacharya, Samit K., Liras, Spiros, Price, David A. and Craik, David J. (2014) Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro. Chemistry and Biology, 21 2: 284-294. doi:10.1016/j.chembiol.2013.11.014

Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2

Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014) Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2. Angewandte Chemie International Edition, 53 4: 1017-1020. doi:10.1002/anie.201308898

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014) Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie, 126 4: 1035-1038. doi:10.1002/ange.201308898

Semienzymatic cyclization of disulfide-rich peptides using sortase A

Jia, Xinying, Kwon, Soohyun, Wang, Ching-I Anderson, Huang, Yen-Hua, Chan, Lai Y., Tan, Chia Chia, Rosengren, K. Johan, Mulvenna, Jason P., Schroeder, Christina I. and Craik, David J. (2014) Semienzymatic cyclization of disulfide-rich peptides using sortase A. Journal of Biological Chemistry, Papers in Press 10: 1-25. doi:10.1074/jbc.M113.539262

A novel alpha4/7-conotoxin LvIA from Conus lividus that selectively blocks alpha3 beta2 vs. alpha6/alpha3 beta2 beta3 nicotinic acetylcholine receptors

Luo, Sulan, Zhangsun, Dongting, Schroeder, Christina I., Zhu, Xiaopeng, Hu, Yuanyan, Wu, Yong, Weltzin, Maegan M., Eberhard, Spencer, Kaas, Quentin, Craik, David J., McIntosh, J. Michael and Whiteaker, Paul (2014) A novel alpha4/7-conotoxin LvIA from Conus lividus that selectively blocks alpha3 beta2 vs. alpha6/alpha3 beta2 beta3 nicotinic acetylcholine receptors. FASEB Journal, Early Edition 4: 1-12. doi:10.1096/fj.13-244103

Spinal actions of omega-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model

Jayamanne, A., Jeong, H. J., Schroeder, C. I., Lewis, R. J., Christie, M. J. and Vaughan, C. W. (2013) Spinal actions of omega-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model. British Journal of Pharmacology, 170 2: 245-254. doi:10.1111/bph.12251

Peptides from Mamba venom as pain killers

Craik, David J. and Schroeder, Christina I. (2013) Peptides from Mamba venom as pain killers. Angewandte Chemie-International Edition, 52 11: 3071-3073. doi:10.1002/anie.201209851

Recent progress towards pharmaceutical applications of disulfide-rich cyclic peptides

Schroeder, Christina I., Swedberg, Joakim E. and Craik, David J. (2013) Recent progress towards pharmaceutical applications of disulfide-rich cyclic peptides. Current Protein and Peptide Science, 14 6: 532-552. doi:10.2174/13892037113149990069

Therapeutic potential of conopeptides

Schroeder, Christina I. and Craik, David J. (2012) Therapeutic potential of conopeptides. Future Medicinal Chemistry, 4 10: 1243-1255. doi:10.4155/FMC.12.70

Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID

Schroeder, Christina I., Nielsen, Katherine J., Adams, Denise A., Loughnan, Marion L., Thomas, Linda, Alewood, Paul F., Lewis, Richard J. and Craik, David J. (2012) Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID. Biopolymers, 98 4: 345-356. doi:10.1002/bip.22031

N- and c-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels

Schroeder, Christina I., Adams, Denise, Thomas, Linda, Alewood, Paul F. and Lewis, Richard J. (2012) N- and c-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers, 98 2: 161-165. doi:10.1002/bip.22032

Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain

Ganderton, Tim, Wong, Jason W. H., Schroeder, Christina and Hogg, Philip J. (2011) Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain. Blood, 118 19: 5312-5318. doi:10.1182/blood-2011-06-360297

Palmitoyl: Protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease

Dawson, Glyn, Schroeder, Christina and Dawson, Philip E. (2010) Palmitoyl: Protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease. Biochemical and Biophysical Research Communications, 395 1: 66-69. doi:10.1016/j.bbrc.2010.03.137

X-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain

Brust, Andreas, Palant, Elka, Croker, Daniel E., Colless, Barbara, Drinkwater, Roger, Patterson, Brad, Schroeder, Christina I., Wilson, David, Nielsen, Carsten K., Smith, Maree T., Alewood, Danne, Alewood, Paul F and Lewis, Richard J. (2009) X-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. Journal of Medicinal Chemistry, 52 22: 6991-7002. doi:10.1021/jm9003413

Neuronally selective micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels

Schroeder, C.I, Ekberg, J, Nielsen, K.J, Adams, D, Loughnan, M L, Thomas, L, Adams, D J, Alewood, P F and Lewis, R J (2008) Neuronally selective micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. Journal of Biological Chemistry, 283 31: 21621-21628. doi:10.1074/jbc.M802852200

Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels

Lewis, Richard J., Schroeder, Christina I., Ekberg, Jenny, Nielsen, Katherine J., Loughnan, Marion, Thomas, Linda, Adams, Denise A., Drinkwater, Roger, Adams, David J. and Alewood, Paul F. (2007) Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels. Molecular Pharmacology, 71 3: 676-685. doi:10.1124/mol.106.028225

AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

Dutertre, S., Ulens, C, Buttner, R, Fish, A, van Elk, R, Kendel, Y, Hopping, G., Alewood, P. F., Schroeder, C., Nicke, A, Smit, AB, Sixma, TK and Lewis, R. J. (2007) AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. Embo Journal, 26 16: 3858-3867. doi:10.1038/sj.emboj.7601785

omega-Conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels

Motin, Leonid, Yasuda, Takahiro, Schroeder, Christina I., Lewis, Richard J. and Adams, David J. (2007) omega-Conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels. European Journal of Neuroscience, 25 2: 435-444. doi:10.1111/j.1460-9568.2006.05299.x

N-type calcium channel blockers: Novel therapeutics for the treatment of pain

Schroeder, I. C., Doering, J., Zamponi, W. and Lewis, R. J. (2006) N-type calcium channel blockers: Novel therapeutics for the treatment of pain. Medicinal Chemistry, 2 5: 535-543. doi:10.2174/157340606778250216

Identification of a novel class of nicotinic receptor antagonists - Dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum

Loughnan, Marion, Nicke, Annette, Jones, Alun, Schroeder, Christina I., Nevin, Simon T., Adams, David J., Alewood, Paul F. and Lewis, Richard J. (2006) Identification of a novel class of nicotinic receptor antagonists - Dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum. Journal of Biological Chemistry, 281 34: 24745-24755. doi:10.1074/jbc.M603703200

Synthesis and biological evaluation of anthranilamide-based non-peptide mimetics of omega-conotoxin GVIA

Baell, Jonathan B., Duggan, Peter J., Forsyth, Stewart A., Lewis, Richard J., Lok, Y. Phei, Schroeder, Christina I. and Shepherd, Nicholas E. (2006) Synthesis and biological evaluation of anthranilamide-based non-peptide mimetics of omega-conotoxin GVIA. Tetrahedron, 62 31: 7284-7292. doi:10.1016/j.tet.2006.05.041

Omega-conotoxins GVIA, MVIIA and CVID: SAR and clinical potential

Schroeder, C. I. and Lewis, R. J. (2006) Omega-conotoxins GVIA, MVIIA and CVID: SAR and clinical potential. Marine Drugs, 4 3: 193-214. doi:10.3390/md403193

The alpha(2)delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Ca(v)2.2) calcium channels

Mould, J., Yasuda, T., Schroeder, C. I., Beedle, A. M., Doering, C. J., Zamponi, G. W., Adams, D. J. and Lewis, R. J. (2004) The alpha(2)delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Ca(v)2.2) calcium channels. Journal of Biological Chemistry, 279 33: 34705-34714. doi:10.1074/jbc.M310848200

Development of small molecules that mimic the binding of w-conotoxins at the N-type voltage-gated calcium channel

Schroeder, I.C., Smythe, M. L. and Lewis, R. J. (2004) Development of small molecules that mimic the binding of w-conotoxins at the N-type voltage-gated calcium channel. Molecular Diversity, 8 2: 127-134. doi:10.1023/B:MODI.0000025656.79632.86

Synthesis and biological evaluation of nonpeptide mimetics of co-conotoxin GVIA

Baell, J. B., Duggan, P. J., Forsyth, S. A., Lewis, R. J., Lok, Y. P. and Schroeder, C. I. (2004) Synthesis and biological evaluation of nonpeptide mimetics of co-conotoxin GVIA. Bioorganic & Medicinal Chemistry, 12 15: 4025-4037. doi:10.1016/j.bmc.2004.05.040

Inhibition of the Norepinephrine Transporter by the Venom Peptide {chi}-MrIA: SITE OF ACTION, Na+ dependence, and structure-activity relationship

Sharpe, Iain A., Palant, Elka, Schroeder, Christina I., Kaye, David M., Adams, David J., Alewood, Paul F. and Lewis, Richard J. (2003) Inhibition of the Norepinephrine Transporter by the Venom Peptide {chi}-MrIA: SITE OF ACTION, Na+ dependence, and structure-activity relationship. Journal of Biological Chemistry, 278 41: 40317-40323. doi:10.1074/jbc.M213030200

ω-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals

Adams, David J., Smith, Amanda B, Schroeder, Christina. I., Yasuda, Takahir and Lewis, Richard J. (2003) ω-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals. Journal of Biological Chemistry, 278 6: 4057-4062. doi:10.1074/jbc.M209969200

Role of third intracellular loop of galanin receptor type 1 in signal transduction

Rezaei, K., Saar, K., Soomets, U., Valkna, A., Nasman, J., Zorko, M., Akerman, K., Schroeder, Ingrid C., Bartfai, T. and Langel, U. (2000) Role of third intracellular loop of galanin receptor type 1 in signal transduction. Neuropeptides, 34 1: 25-31. doi:10.1054/npep.1999.0782

Structure-activity relationships of w-conotoxins at N-type voltage-sensitive calcium channels

Nielsen, K. J., Schroeder, T. and Lewis, R. J. (2000) Structure-activity relationships of w-conotoxins at N-type voltage-sensitive calcium channels. Journal of Molecular Recognition, 13 2: 55-70. doi:10.1002/(SICI)1099-1352(200003/04)13:2<55::AID-JMR488>3.0.CO;2-O

Effects of chirality at Tyr13 on the structure-activity relationships of omega-conotoxins from Conus magus

Nielsen, Katherine J., Adams, Denise A., Alewood, Paul F., Lewis, Richard J., Thomas, Linda, Schroeder, Tina and Craik, David J. (1999) Effects of chirality at Tyr13 on the structure-activity relationships of omega-conotoxins from Conus magus. Biochemistry, 38 21: 6741-6751. doi:10.1021/bi982980u

Small molecule and peptidic ligands as PCSK9-LDLR inhibitors

Bhattacharya, Samit, Ammirati, Mark, Borzilleri, Kris, Cheneval, Olivier, Chrunyk, Boris, Craik, David, Daly, Norelle, Dullea, Robert, Griffor, Matthew, Kamlet, Adam, Limberakis, Chris, Sahasrabudhe, Parag, Liu, Shenping, Loria, Paula, Mc Clure, Kim, Menhaji-Klotz, Elnaz, Petersen, Donna, Piotrowski, David, Popovska-Gorevski, Marina, Price, David, Reyes, Allan, Ruggeri, Roger, Schroeder, Christina, Song, Kun, Swedberg, Joakim, Stock, Ingrid, Tu, Meihua and Withka, Jane (2017). Small molecule and peptidic ligands as PCSK9-LDLR inhibitors. In: 254th National Meeting and Exposition of the American-Chemical-Society (ACS) on Chemistry's Impact on the Global Economy, Washington, DC, (). 20-24 August 2017 .

The importance of peptide-membrane interactions in toxin inhibitions of sodium channels

Schroeder, Christina I., Deplazes, Evelyn, Lawrence, Nicole, Agwa, Akello and Henriques, Sonia T. (2017). The importance of peptide-membrane interactions in toxin inhibitions of sodium channels. In: 58th Annual Meeting of the Biophysical Society, San Francisco, United States, (226A-226A). 15-19 February 2014. doi:10.1016/j.bpj.2016.11.1247

Membrane-binding properties of gating-modifier and pore blocking toxins: membrane interaction is not a prerequisite for modification of channel gating

Deplazes, Evelyne, Henriques, Sonia Troeira, King, Glenn F., Craik, David J., Mark, Alan E. and Schroeder, Christina I. (2016). Membrane-binding properties of gating-modifier and pore blocking toxins: membrane interaction is not a prerequisite for modification of channel gating. In: 60th Annual Meeting of the Biophysical-Society, Los Angeles, United States, (29A-29A). February 27- March 2 2016. doi:10.1016/j.bpj.2015.11.220

Rational design and synthesis of a novel membrane binding NaV1.8 selective inhibitor with in vivo activity in pain models

Schroeder, Christina I., Deuis, Jennifer, Henriques, Sonia Troeria, Dekan, Zoltan, Inserra, Marco, Mobli, Mehdi and Vetter, Irina (2016). Rational design and synthesis of a novel membrane binding NaV1.8 selective inhibitor with in vivo activity in pain models. In: 60th Annual Meeting of the Biophysical Society, Los Angeles, CA, United States, (33A-33A). 27 Feb - 2 Mar 2016. doi:10.1016/j.bpj.2015.11.247

Structure-Activity Relationship Studies Reveal that the Spider Toxin Protx-II has Unusual Membrane-Binding Properties and Inhibits NAV1.7 Channel at the Membrane Surface

Henriques, Sonia Troeira, Craik, David J. and Schroeder, Christina I. (2016). Structure-Activity Relationship Studies Reveal that the Spider Toxin Protx-II has Unusual Membrane-Binding Properties and Inhibits NAV1.7 Channel at the Membrane Surface. In: 60th Annual Meeting of the Biophysical-Society, Los Angeles, CA, United States, (76A-76A). Feb 27-Mar 02, 2016.

Delineating toxin:lipid:ion channel interactions for rationally sodium channel inhibitors design

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Structural studies of AChBP, a soluble nicotinic acetylcholine receptor homolog, in complex with novel ligands

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Conopeptide to drug: The development, structure and activity correlation of XEN2174

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Peptides - From Discovery to Therapeutics

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From Omega-Conotoxins to Macrocycle Mimetics

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Inhibition of neurotransmitter release by novel w-conotoxins in rat preganglionic terminals

Smith, A. B., Schroeder, T. I. C., Lewis, R. J., Alewood, P. F. and Adams, D. J. (2001). Inhibition of neurotransmitter release by novel w-conotoxins in rat preganglionic terminals. In: Proceedings of the Physiological Society Scientific Meeting. Physiological Society Scientific Meeting, King's College, London, (70-70). 18 - 20 December, 2000.

Inhibition of neurotransmitter release by novel w-conotoxins in rat submandibular ganglia

Smith, A. B., Schroeder, T. I. C., Lewis, R. J., Alewood, P. F. and Adams, D. J. (2000). Inhibition of neurotransmitter release by novel w-conotoxins in rat submandibular ganglia. In: Abstracts of the Australian Neuroscience Society. 20th Annual Meeting of the Australian Neuroscience Society, Melbourne Convention Centre, Melbourne, Australia, (232-232). 30 January - 2 February, 2000.