Christina Schroeder received her MSc in Chemistry from University of Kalmar, Sweden in 1998. As part of her masters, she joined Prof Richard Lewis for a 6-month internship at the Centre for Drug, Design and Development, The University of Queensland, working on conotoxins inhibiting calcium channels. After her masters, she worked as a Research Assistant at the Karolinska hospital and Stockholm University in Sweden until she returned to Australia in 1999 to conduct her PhD at the Institute for Molecular Bioscience (IMB), The University of Queensland under supervision of Professor Richard Lewis and Professor David Craik working on the development of an omega-conotoxin pharmacophore. After completing her PhD in 2003, she carried out a postdoc in Professor Lewis' laboratory until 2006, when she joined Professor Philip Dawson’s laboratory at The Scripps Research Institute, La Jolla, USA to work on developing palmitoylated peptides as chaperones for infantile Batten disease. In 2007, she moved back to Australia, to join Professor Philip Hogg’s laboratory at the University of New South Wales in Sydney where she worked on the multimerisation of large proteins via disulfide bonds. In 2011 she was recruite back to IMB to join Professor David Craik’s group. Dr Schroeder's research is focussed on using bioactive peptides in drug design and to understand the mode of action of toxins binding to sodium channels and their surrounding membranes with the ultimate goal to develop novel non-addictive pain therapeutics.
Book Chapter: Three-dimensional structure determination of peptides using solution nuclear magnetic resonance spectroscopy
Schroeder, Christina I. and Rosengren, K. Johan (2020). Three-dimensional structure determination of peptides using solution nuclear magnetic resonance spectroscopy. In Snake and spider toxins: methods and protocols (pp. 129-162) New York, NY USA: Humana Press. doi:10.1007/978-1-4939-9845-6_7
Journal Article: Fluorescence Imaging of Peripheral Nerves by a Nav1.7-Targeted Inhibitor Cystine Knot Peptide
Gonzales, Junior, Demetrio de Souza Franca, Paula, Jiang, Yan, Pirovano, Giacomo, Kossatz, Susanne, Guru, Navjot, Yarilin, Dimitry, Agwa, Akello J., Schroeder, Christina I, Patel, Snehal, Ganly, Ian, King, Glenn F. and Reiner, Thomas (2019) Fluorescence Imaging of Peripheral Nerves by a Nav1.7-Targeted Inhibitor Cystine Knot Peptide. Bioconjugate Chemistry, . doi:10.1021/acs.bioconjchem.9b00612
Mueller, Alexander, Starobova, Hana, Morgan, Michael, Dekan, Zoltan, Cheneval, Olivier, Schroeder, Christina I., Alewood, Paul F., Deuis, Jennifer R. and Vetter, Irina (2019) Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen. Pain, 160 8: 1766-1780. doi:10.1097/j.pain.0000000000001567
Novel multifunctional analgesic sodium channel inhibitors
(2020–2022) NHMRC IDEAS Grants
Aquatic chemo-modulators - a novel source for potent molecular probes
(2019–2022) ARC Discovery Projects
(2019) UQ Major Equipment and Infrastructure
(2019) Doctor Philosophy
Development of novel screening tools for peptide modulators of voltage-gated ion channels
Doctor Philosophy
Trefoil factor family: chemical synthesis, mechanisms of action and therapeutic potential for gastrointestinal disorders
Doctor Philosophy
Schroeder, Christina I. and Rosengren, K. Johan (2020). Three-dimensional structure determination of peptides using solution nuclear magnetic resonance spectroscopy. In Snake and spider toxins: methods and protocols (pp. 129-162) New York, NY USA: Humana Press. doi:10.1007/978-1-4939-9845-6_7
Cyclizing disulfide-rich peptides using sortase A
Agwa, Akello J., Craik, David J. and Schroeder, Christina I. (2019). Cyclizing disulfide-rich peptides using sortase A. In Timo Nuijens and Marcel Schmidt (Ed.), Methods in Molecular Biology (pp. 29-41) New York, NY, United States: Humana Press. doi:10.1007/978-1-4939-9546-2_3
Block of voltage-gated calcium channels by peptide toxins
Schroeder, C. I., Lewis, R. J. and Adams, D. J. (2005). Block of voltage-gated calcium channels by peptide toxins. In Gerald W. Zamponi (Ed.), Voltage-Gated Calcium Channels (pp. 294-308) New York, U.S.A.: Springer US. doi:10.1007/0-387-27526-6_19
Fluorescence Imaging of Peripheral Nerves by a Nav1.7-Targeted Inhibitor Cystine Knot Peptide
Gonzales, Junior, Demetrio de Souza Franca, Paula, Jiang, Yan, Pirovano, Giacomo, Kossatz, Susanne, Guru, Navjot, Yarilin, Dimitry, Agwa, Akello J., Schroeder, Christina I, Patel, Snehal, Ganly, Ian, King, Glenn F. and Reiner, Thomas (2019) Fluorescence Imaging of Peripheral Nerves by a Nav1.7-Targeted Inhibitor Cystine Knot Peptide. Bioconjugate Chemistry, . doi:10.1021/acs.bioconjchem.9b00612
Mueller, Alexander, Starobova, Hana, Morgan, Michael, Dekan, Zoltan, Cheneval, Olivier, Schroeder, Christina I., Alewood, Paul F., Deuis, Jennifer R. and Vetter, Irina (2019) Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen. Pain, 160 8: 1766-1780. doi:10.1097/j.pain.0000000000001567
Mueller, Alexander, Starobova, Hana, Morgan, Michael, Dekan, Zoltan, Cheneval, Olivier, Schroeder, Christina I., Alewood, Paul F., Deuis, Jennifer R. and Vetter, Irina (2019) Anti-allodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute post-surgical pain: evidence for analgesic synergy with opioids and baclofen. Pain, . doi:10.1097/j.pain.0000000000001567
Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors
Peigneur, Steve, Cheneval, Olivier, Maiti, Mohitosh, Leipold, Enrico, Heinemann, Stefan H., Lescrinier, Eveline, Herdewijn, Piet, De Lima, Maria Elena, Craik, David J., Schroeder, Christina I. and Tytgat, Jan (2019) Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors. FASEB Journal, 33 3: 3693-3703. doi:10.1096/fj.201801909R
Lawrence, Nicole, Wu, Bin, Ligutti, Joseph, Cheneval, Olivier, Agwa, Akello Joanna, Benfield, Aurélie H., Biswas, Kaustav, Craik, David J., Miranda, Les P., Henriques, Sónia Troeira and Schroeder, Christina I. (2018) Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1. ACS Chemical Biology, . doi:10.1021/acschembio.8b00989
Targeted delivery of cyclotides via conjugation to a nanobody
Kwon, Soohyun, Duarte, Joao N., Li, Zeyang, Ling, Jingjing J., Cheneval, Olivier, Durek, Thomas, Schroeder, Christina I., Craik, David J. and Ploegh, Hidde L. (2018) Targeted delivery of cyclotides via conjugation to a nanobody. ACS Chemical Biology, 13 10: 2973-2980. doi:10.1021/acschembio.8b00653
Agwa, Akello J., Blomster, Linda V., Craik, David J., King, Glenn F. and Schroeder, Christina I. (2018) Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase a to form double-knottins that probe voltage-gated sodium channel NaV1.7. Bioconjugate Chemistry, 29 10: 3309-3319. doi:10.1021/acs.bioconjchem.8b00505
de Veer, Simon J., Li, Choi Yi, Swedberg, Joakim E., Schroeder, Christina I. and Craik, David J. (2018) Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1. European Journal of Medicinal Chemistry, 155 695-704. doi:10.1016/j.ejmech.2018.06.029
Calcium-mediated allostery of the EGF fold
Wang, Conan K., Ghani, Hafiza Abdul, Bundock, Anna, Weidmann, Joachim, Harvey, Peta J., Edwards, Ingrid A., Schroeder, Christina I., Swedberg, Joakim E. and Craik, David J. (2018) Calcium-mediated allostery of the EGF fold. ACS Chemical Biology, 13 6: 1659-1667. doi:10.1021/acschembio.8b00291
Agwa, Akello J., Peigneur, Steve, Chow, Chun Yuen, Lawrence, Nicole, Craik, David J., Tytgat, Jan, King, Glenn F., Henriques, Sonia Troeira and Schroeder, Christina I. (2018) Gating modifier toxins isolated from spider venom: modulation of voltage-gated sodium channels and the role of lipid membranes. Journal of Biological Chemistry, 293 23: 9041-9052. doi:10.1074/jbc.RA118.002553
Durek, Thomas, Cromm, Philipp M., White, Andrew M., Schroeder, Christina I., Kaas, Quentin, Weidmann, Joachim, Ahmad Fuaad, Abdullah, Cheneval, Olivier, Harvey, Peta J., Daly, Norelle L., Zhou, Yang, Dellsén, Anita, Österlund, Torben, Larsson, Niklas, Knerr, Laurent, Bauer, Udo, Kessler, Horst, Cai, Minying, Hruby, Victor J., Plowright, Alleyn T. and Craik, David J. (2018) Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1. Journal of Medicinal Chemistry, 61 8: 3674-3684. doi:10.1021/acs.jmedchem.8b00170
Bioactive compounds isolated from neglected predatory marine gastropods
Turner, Ashlin H., Craik, David J., Kaas, Quentin and Schroeder, Christina I. (2018) Bioactive compounds isolated from neglected predatory marine gastropods. Marine Drugs, 16 4: 118. doi:10.3390/md16040118
Agwa, Akello J., Lawrence, Nicole, Deplazes, Evelyne, Cheneval, Olivier, Chen, Rachel M., Craik, David J., Schroeder, Christina I. and Henriques, Sonia T. (2017) Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNa(V)1.7 (vol 1859, pg 835, 2017). Biochimica Et Biophysica Acta-Biomembranes, 1859 11: 2277-2277. doi:10.1016/j.bbamem.2017.08.008
Agwa, Akello J., Huang, Yen-Hua, Craik, David J., Henriques, Sonia T. and Schroeder, Christina I. (2017) Lengths of the C-terminus and interconnecting loops impact stability of spider-derived gating modifier toxins. Toxins, 9 8: 248. doi:10.3390/toxins9080248
Modelling the interactions between animal venom peptides and membrane proteins
Hung, Andrew, Kuyucak, Serdar, Schroeder, Christina I. and Kaas, Quentin (2017) Modelling the interactions between animal venom peptides and membrane proteins. Neuropharmacology, 127 20-31. doi:10.1016/j.neuropharm.2017.07.036
Agwa, Akello J., Lawrence, Nicole, Deplazes, Evelyne, Cheneval, Olivier, Chen, Rachel M., Craik, David J., Schroeder, Christina I. and Henriques, Sónia T. (2017) Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7. Biochimica et Biophysica Acta. Biomembranes, 1859 5: 835-844. doi:10.1016/j.bbamem.2017.01.020
Agwa, Akello J., Henriques, Sónia T. and Schroeder, Christina I. (2017) Gating modifier toxin interactions with ion channels and lipid bilayers: Is the trimolecular complex real?. Neuropharmacology, 127 32-45. doi:10.1016/j.neuropharm.2017.04.004
Abdul Ghani, Hafiza, Henriques, Sonia Troeira, Huang, Yen-Hua, Swedberg, Joakim E. , Schroeder, Christina I. and Craik, David J. (2017) Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies. Biopolymers, 108 1: . doi:10.1002/bip.22927
Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide
Kwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I. and Craik, David J. (2016) Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering, 113 10: 2202-2212. doi:10.1002/bit.25993
Troeira Henriques, Sonia, Deplazes, Evelyne, Lawrence, Nicole, Cheneval, Olivier, Chaousis, Stephanie, Inserra, Marco, Thongyoo, Panumart, King, Glenn F., Mark, Alan E., Vetter, Irina, Craik, David J. and Schroeder, Christina Ingrid (2016) Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1.7. The Journal of Biological Chemistry, 291 33: 17049-17065. doi:10.1074/jbc.M116.729095
Swedberg, Joakim E., Mahatmanto, Tunjung, Ghani, Hafiza Abdul, de Veer, Simon J., Schroeder, Christina I., Harris, Jonathan M. and Craik, David J. (2016) Substrate-guided design of selective FXIIa inhibitors based on the plant-derived Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold. Journal of Medicinal Chemistry, 59 15: 7287-7292. doi:10.1021/acs.jmedchem.6b00557
Swedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Price, David A., Liras, Spiros and Craik, David J. (2016) Truncated glucagon-like peptide-1 and exendin-4 α-conotoxin pl14a peptide chimeras maintain potency and α-helicity and reveal interactions vital for cAMP signaling in vitro. Journal of Biological Chemistry, 291 30: 15778-15787. doi:10.1074/jbc.M116.724542
Deuis, Jennifer R, Dekan, Zoltan, Inserra, Marco C., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Craik, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Schroeder, Christina I., Henriques, Sónia Troeira and Vetter, Irina (2016) Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8. Journal of Biological Chemistry, 291 22: 11829-11842. doi:10.1074/jbc.M116.721662
Deplazes, Evelyne, Troeira Henriques, Sonia, Smith, Jennifer J., King, Glenn F., Craik, David J., Mark, Alan E. and Schroeder, Christina I. (2016) Membrane-binding properties of gating modifier and pore-blocking toxins: membrane interaction is not a prerequisite for modification of channel gating. Biochimica et Biophysica Acta - Biomembranes, 1858 4: 872-882. doi:10.1016/j.bbamem.2016.02.002
Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization
Conibear, Anne C., Chaousis, Stephanie, Durek, Thomas, Rosengren, K. Johan, Craik, David J. and Schroeder, Christina I. (2016) Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization. Biopolymers, 106 1: 89-100. doi:10.1002/bip.22767
Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists
Swedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Durek, Thomas, Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Liras, Spiros, Price, David A. and Craik, David J. (2015) Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists. European Journal of Medicinal Chemistry, 103 175-184. doi:10.1016/j.ejmech.2015.08.046
Wang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David, A., Fairlie, David and Craik, David J. (2014) Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 111 49: 17504-17509. doi:10.1073/pnas.1417611111
Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed
Hill, Timothy A., Lohman, Rink-Jan, Hoang, Huy N., Nielsen, Daniel S., Scully, Conor C. G., Kok, W. Mei, Liu, Ligong, Lucke, Andrew J., Stoermer, Martin J., Schroeder, Christina I., Chaousis, Stephanie, Colless, Barbara, Bernhardt, Paul V., Edmonds, David J., Griffith, David A., Rotter, Charles J., Ruggeri, Roger B., Price, David A., Liras, Spiros, Craik, David J. and Fairlie, David P. (2014) Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed. ACS Medicinal Chemistry Letters, 5 10: 1148-1151. doi:10.1021/ml5002823
Fmoc-based synthesis of disulfide-rich cyclic peptides
Cheneval, Olivier, Schroeder, Christina I., Durek, Thomas, Walsh, Phillip, Huang, Yen-Hua, Liras, Spiros, Price, David A. and Craik, David J. (2014) Fmoc-based synthesis of disulfide-rich cyclic peptides. Journal of Organic Chemistry, 79 12: 5538-5544. doi:10.1021/jo500699m
Brust, Andreas, Schroeder, Christina I. and Alewood, Paul F. (2014) High-throughput synthesis of peptide alpha-thioesters: a safety catch linker approach enabling parallel hydrogen fluoride cleavage. ChemMedChem, 9 5: 1038-1046. doi:10.1002/cmdc.201300524
Disulfide-rich macrocyclic peptides as templates in drug design
Northfield, Susan E., Wang, Conan K., Schroeder, Christina I., Durek, Thomas, Kan, Meng-Wei, Swedberg, Joakim E. and Craik, David J. (2014) Disulfide-rich macrocyclic peptides as templates in drug design. European Journal of Medicinal Chemistry, 77 2: 248-257. doi:10.1016/j.ejmech.2014.03.011
Schroeder, Christina I., Swedberg, Joakim E., Withka, Jane M., Rosengren, K. Johan, Akcan, Muharrem, Clayton, Daniel J., Daly, Norelle L., Cheneval, Olivier, Borzilleri, Kris A., Griffor, Matt, Stock, Ingrid, Colless, Barbara, Walsh, Phillip, Sunderland, Phillip, Reyes, Allan, Dullea, Robert, Ammirati, Mark, Liu, Shenping, McClure, Kim F., Tu, Meihua, Bhattacharya, Samit K., Liras, Spiros, Price, David A. and Craik, David J. (2014) Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro. Chemistry and Biology, 21 2: 284-294. doi:10.1016/j.chembiol.2013.11.014
Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2
Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014) Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2. Angewandte Chemie International Edition, 53 4: 1017-1020. doi:10.1002/anie.201308898
Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2
Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014) Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie, 126 4: 1035-1038. doi:10.1002/ange.201308898
Semienzymatic cyclization of disulfide-rich peptides using sortase A
Jia, Xinying, Kwon, Soohyun, Wang, Ching-I Anderson, Huang, Yen-Hua, Chan, Lai Y., Tan, Chia Chia, Rosengren, K. Johan, Mulvenna, Jason P., Schroeder, Christina I. and Craik, David J. (2014) Semienzymatic cyclization of disulfide-rich peptides using sortase A. Journal of Biological Chemistry, Papers in Press 10: 1-25. doi:10.1074/jbc.M113.539262
Luo, Sulan, Zhangsun, Dongting, Schroeder, Christina I., Zhu, Xiaopeng, Hu, Yuanyan, Wu, Yong, Weltzin, Maegan M., Eberhard, Spencer, Kaas, Quentin, Craik, David J., McIntosh, J. Michael and Whiteaker, Paul (2014) A novel alpha4/7-conotoxin LvIA from Conus lividus that selectively blocks alpha3 beta2 vs. alpha6/alpha3 beta2 beta3 nicotinic acetylcholine receptors. FASEB Journal, Early Edition 4: 1-12. doi:10.1096/fj.13-244103
Spinal actions of omega-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model
Jayamanne, A., Jeong, H. J., Schroeder, C. I., Lewis, R. J., Christie, M. J. and Vaughan, C. W. (2013) Spinal actions of omega-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model. British Journal of Pharmacology, 170 2: 245-254. doi:10.1111/bph.12251
Peptides from Mamba venom as pain killers
Craik, David J. and Schroeder, Christina I. (2013) Peptides from Mamba venom as pain killers. Angewandte Chemie-International Edition, 52 11: 3071-3073. doi:10.1002/anie.201209851
Recent progress towards pharmaceutical applications of disulfide-rich cyclic peptides
Schroeder, Christina I., Swedberg, Joakim E. and Craik, David J. (2013) Recent progress towards pharmaceutical applications of disulfide-rich cyclic peptides. Current Protein and Peptide Science, 14 6: 532-552. doi:10.2174/13892037113149990069
Therapeutic potential of conopeptides
Schroeder, Christina I. and Craik, David J. (2012) Therapeutic potential of conopeptides. Future Medicinal Chemistry, 4 10: 1243-1255. doi:10.4155/FMC.12.70
Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID
Schroeder, Christina I., Nielsen, Katherine J., Adams, Denise A., Loughnan, Marion L., Thomas, Linda, Alewood, Paul F., Lewis, Richard J. and Craik, David J. (2012) Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID. Biopolymers, 98 4: 345-356. doi:10.1002/bip.22031
Schroeder, Christina I., Adams, Denise, Thomas, Linda, Alewood, Paul F. and Lewis, Richard J. (2012) N- and c-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers, 98 2: 161-165. doi:10.1002/bip.22032
Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain
Ganderton, Tim, Wong, Jason W. H., Schroeder, Christina and Hogg, Philip J. (2011) Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain. Blood, 118 19: 5312-5318. doi:10.1182/blood-2011-06-360297
Dawson, Glyn, Schroeder, Christina and Dawson, Philip E. (2010) Palmitoyl: Protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease. Biochemical and Biophysical Research Communications, 395 1: 66-69. doi:10.1016/j.bbrc.2010.03.137
Brust, Andreas, Palant, Elka, Croker, Daniel E., Colless, Barbara, Drinkwater, Roger, Patterson, Brad, Schroeder, Christina I., Wilson, David, Nielsen, Carsten K., Smith, Maree T., Alewood, Danne, Alewood, Paul F and Lewis, Richard J. (2009) X-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. Journal of Medicinal Chemistry, 52 22: 6991-7002. doi:10.1021/jm9003413
Schroeder, C.I, Ekberg, J, Nielsen, K.J, Adams, D, Loughnan, M L, Thomas, L, Adams, D J, Alewood, P F and Lewis, R J (2008) Neuronally selective micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. Journal of Biological Chemistry, 283 31: 21621-21628. doi:10.1074/jbc.M802852200
Lewis, Richard J., Schroeder, Christina I., Ekberg, Jenny, Nielsen, Katherine J., Loughnan, Marion, Thomas, Linda, Adams, Denise A., Drinkwater, Roger, Adams, David J. and Alewood, Paul F. (2007) Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels. Molecular Pharmacology, 71 3: 676-685. doi:10.1124/mol.106.028225
Dutertre, S., Ulens, C, Buttner, R, Fish, A, van Elk, R, Kendel, Y, Hopping, G., Alewood, P. F., Schroeder, C., Nicke, A, Smit, AB, Sixma, TK and Lewis, R. J. (2007) AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. Embo Journal, 26 16: 3858-3867. doi:10.1038/sj.emboj.7601785
omega-Conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels
Motin, Leonid, Yasuda, Takahiro, Schroeder, Christina I., Lewis, Richard J. and Adams, David J. (2007) omega-Conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels. European Journal of Neuroscience, 25 2: 435-444. doi:10.1111/j.1460-9568.2006.05299.x
N-type calcium channel blockers: Novel therapeutics for the treatment of pain
Schroeder, I. C., Doering, J., Zamponi, W. and Lewis, R. J. (2006) N-type calcium channel blockers: Novel therapeutics for the treatment of pain. Medicinal Chemistry, 2 5: 535-543. doi:10.2174/157340606778250216
Loughnan, Marion, Nicke, Annette, Jones, Alun, Schroeder, Christina I., Nevin, Simon T., Adams, David J., Alewood, Paul F. and Lewis, Richard J. (2006) Identification of a novel class of nicotinic receptor antagonists - Dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum. Journal of Biological Chemistry, 281 34: 24745-24755. doi:10.1074/jbc.M603703200
Baell, Jonathan B., Duggan, Peter J., Forsyth, Stewart A., Lewis, Richard J., Lok, Y. Phei, Schroeder, Christina I. and Shepherd, Nicholas E. (2006) Synthesis and biological evaluation of anthranilamide-based non-peptide mimetics of omega-conotoxin GVIA. Tetrahedron, 62 31: 7284-7292. doi:10.1016/j.tet.2006.05.041
Omega-conotoxins GVIA, MVIIA and CVID: SAR and clinical potential
Schroeder, C. I. and Lewis, R. J. (2006) Omega-conotoxins GVIA, MVIIA and CVID: SAR and clinical potential. Marine Drugs, 4 3: 193-214. doi:10.3390/md403193
Mould, J., Yasuda, T., Schroeder, C. I., Beedle, A. M., Doering, C. J., Zamponi, G. W., Adams, D. J. and Lewis, R. J. (2004) The alpha(2)delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Ca(v)2.2) calcium channels. Journal of Biological Chemistry, 279 33: 34705-34714. doi:10.1074/jbc.M310848200
Schroeder, I.C., Smythe, M. L. and Lewis, R. J. (2004) Development of small molecules that mimic the binding of w-conotoxins at the N-type voltage-gated calcium channel. Molecular Diversity, 8 2: 127-134. doi:10.1023/B:MODI.0000025656.79632.86
Synthesis and biological evaluation of nonpeptide mimetics of co-conotoxin GVIA
Baell, J. B., Duggan, P. J., Forsyth, S. A., Lewis, R. J., Lok, Y. P. and Schroeder, C. I. (2004) Synthesis and biological evaluation of nonpeptide mimetics of co-conotoxin GVIA. Bioorganic & Medicinal Chemistry, 12 15: 4025-4037. doi:10.1016/j.bmc.2004.05.040
Sharpe, Iain A., Palant, Elka, Schroeder, Christina I., Kaye, David M., Adams, David J., Alewood, Paul F. and Lewis, Richard J. (2003) Inhibition of the Norepinephrine Transporter by the Venom Peptide {chi}-MrIA: SITE OF ACTION, Na+ dependence, and structure-activity relationship. Journal of Biological Chemistry, 278 41: 40317-40323. doi:10.1074/jbc.M213030200
Adams, David J., Smith, Amanda B, Schroeder, Christina. I., Yasuda, Takahir and Lewis, Richard J. (2003) ω-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals. Journal of Biological Chemistry, 278 6: 4057-4062. doi:10.1074/jbc.M209969200
Role of third intracellular loop of galanin receptor type 1 in signal transduction
Rezaei, K., Saar, K., Soomets, U., Valkna, A., Nasman, J., Zorko, M., Akerman, K., Schroeder, Ingrid C., Bartfai, T. and Langel, U. (2000) Role of third intracellular loop of galanin receptor type 1 in signal transduction. Neuropeptides, 34 1: 25-31. doi:10.1054/npep.1999.0782
Structure-activity relationships of w-conotoxins at N-type voltage-sensitive calcium channels
Nielsen, K. J., Schroeder, T. and Lewis, R. J. (2000) Structure-activity relationships of w-conotoxins at N-type voltage-sensitive calcium channels. Journal of Molecular Recognition, 13 2: 55-70. doi:10.1002/(SICI)1099-1352(200003/04)13:2<55::AID-JMR488>3.0.CO;2-O
Nielsen, Katherine J., Adams, Denise A., Alewood, Paul F., Lewis, Richard J., Thomas, Linda, Schroeder, Tina and Craik, David J. (1999) Effects of chirality at Tyr13 on the structure-activity relationships of omega-conotoxins from Conus magus. Biochemistry, 38 21: 6741-6751. doi:10.1021/bi982980u
Small molecule and peptidic ligands as PCSK9-LDLR inhibitors
Bhattacharya, Samit, Ammirati, Mark, Borzilleri, Kris, Cheneval, Olivier, Chrunyk, Boris, Craik, David, Daly, Norelle, Dullea, Robert, Griffor, Matthew, Kamlet, Adam, Limberakis, Chris, Sahasrabudhe, Parag, Liu, Shenping, Loria, Paula, Mc Clure, Kim, Menhaji-Klotz, Elnaz, Petersen, Donna, Piotrowski, David, Popovska-Gorevski, Marina, Price, David, Reyes, Allan, Ruggeri, Roger, Schroeder, Christina, Song, Kun, Swedberg, Joakim, Stock, Ingrid, Tu, Meihua and Withka, Jane (2017). Small molecule and peptidic ligands as PCSK9-LDLR inhibitors. In: 254th National Meeting and Exposition of the American-Chemical-Society (ACS) on Chemistry's Impact on the Global Economy, Washington, DC, (). 20-24 August 2017 .
The importance of peptide-membrane interactions in toxin inhibitions of sodium channels
Schroeder, Christina I., Deplazes, Evelyn, Lawrence, Nicole, Agwa, Akello and Henriques, Sonia T. (2017). The importance of peptide-membrane interactions in toxin inhibitions of sodium channels. In: 58th Annual Meeting of the Biophysical Society, San Francisco, United States, (226A-226A). 15-19 February 2014. doi:10.1016/j.bpj.2016.11.1247
Deplazes, Evelyne, Henriques, Sonia Troeira, King, Glenn F., Craik, David J., Mark, Alan E. and Schroeder, Christina I. (2016). Membrane-binding properties of gating-modifier and pore blocking toxins: membrane interaction is not a prerequisite for modification of channel gating. In: 60th Annual Meeting of the Biophysical-Society, Los Angeles, United States, (29A-29A). February 27- March 2 2016. doi:10.1016/j.bpj.2015.11.220
Schroeder, Christina I., Deuis, Jennifer, Henriques, Sonia Troeria, Dekan, Zoltan, Inserra, Marco, Mobli, Mehdi and Vetter, Irina (2016). Rational design and synthesis of a novel membrane binding NaV1.8 selective inhibitor with in vivo activity in pain models. In: 60th Annual Meeting of the Biophysical Society, Los Angeles, CA, United States, (33A-33A). 27 Feb - 2 Mar 2016. doi:10.1016/j.bpj.2015.11.247
Henriques, Sonia Troeira, Craik, David J. and Schroeder, Christina I. (2016). Structure-Activity Relationship Studies Reveal that the Spider Toxin Protx-II has Unusual Membrane-Binding Properties and Inhibits NAV1.7 Channel at the Membrane Surface. In: 60th Annual Meeting of the Biophysical-Society, Los Angeles, CA, United States, (76A-76A). Feb 27-Mar 02, 2016.
Delineating toxin:lipid:ion channel interactions for rationally sodium channel inhibitors design
Schroeder, Christina, Henriques, Sonia, Mobli, Mehdi, Chaousis, Stephanie, Walsh, Phillip, Thongyoo, Panumart and Craik, David (2015). Delineating toxin:lipid:ion channel interactions for rationally sodium channel inhibitors design. In: 29th Annual Symposium of the Protein Society, Barcelona Spain, (16-17). Jul 22-25, 2015. doi:10.1002/pro.2823
Ulens, Chris, Dutertre, Sebastien, Hopping, Gene, Fish, Alex, Schroeder, Christina, van Elk, Rene, Akdemir, Atilla, de Esch, Iwan, Nicke, Annette, Alewood, Paul, Lewis, Richard, Smit, August B. and Perrakis, Anastassis (2007). Structural studies of AChBP, a soluble nicotinic acetylcholine receptor homolog, in complex with novel ligands. In: Biophysical Journal. 51st Annual Meeting of the Biophysical-Society, Baltimore Md, (453A-454A). Mar 03-07, 2007.
Conopeptide to drug: The development, structure and activity correlation of XEN2174
Brust, A., Alewood, D., Colless, B., Palant, E., Patterson, B., Wilson, D. T. R., Watson, F., Schroeder, C. I., Alewood, P. F. and Lewis, R. J. (2006). Conopeptide to drug: The development, structure and activity correlation of XEN2174. In: Journal Of Peptide Science: 29th European Peptide Symposium proceedings. 29th European Peptide Symposium, Gdansk, Poland, (516-516). 3-8 September, 2006,. doi:10.1002/psc.797
Peptides - From Discovery to Therapeutics
Lew, Rebecca, Aguilar, Mibel and Schroeder, Christina (2006). Peptides - From Discovery to Therapeutics. In: International Journal Of Peptide Research and Therapeutics: Australian Peptide Conference. Australian Peptide Conference, Brisbane, (195-195). June 2006. doi:10.1007/s10989-006-9035-2
From Omega-Conotoxins to Macrocycle Mimetics
Schroeder, CI, Nielsen, KJ, Adams, DA, Loughnan, M, Thomas, L, Bourne, GT, Smythe, ML, Alewood, PF, Craik, DJ and Lewis, RJ (2004). From Omega-Conotoxins to Macrocycle Mimetics. In: Journal of Peptide Science. , , (95-95). .
Inhibition of neurotransmitter release by novel w-conotoxins in rat preganglionic terminals
Smith, A. B., Schroeder, T. I. C., Lewis, R. J., Alewood, P. F. and Adams, D. J. (2001). Inhibition of neurotransmitter release by novel w-conotoxins in rat preganglionic terminals. In: Proceedings of the Physiological Society Scientific Meeting. Physiological Society Scientific Meeting, King's College, London, (70-70). 18 - 20 December, 2000.
Inhibition of neurotransmitter release by novel w-conotoxins in rat submandibular ganglia
Smith, A. B., Schroeder, T. I. C., Lewis, R. J., Alewood, P. F. and Adams, D. J. (2000). Inhibition of neurotransmitter release by novel w-conotoxins in rat submandibular ganglia. In: Abstracts of the Australian Neuroscience Society. 20th Annual Meeting of the Australian Neuroscience Society, Melbourne Convention Centre, Melbourne, Australia, (232-232). 30 January - 2 February, 2000.
Novel multifunctional analgesic sodium channel inhibitors
(2020–2022) NHMRC IDEAS Grants
Aquatic chemo-modulators - a novel source for potent molecular probes
(2019–2022) ARC Discovery Projects
(2019) UQ Major Equipment and Infrastructure
(2018) UQ Major Equipment and Infrastructure
The potential of membranes - peptide engineering to modulate ion channels
(2017–2021) ARC Future Fellowships
Patch-clamp electrophysiology platform for drug and insecticide discovery
(2016) UQ Major Equipment and Infrastructure
Understanding how toxins interact with lipid membranes and ion channels
(2015–2018) NHMRC Project Grant
Development of selective melanocortin receptor agonists and antagonists
(2015–2017) NHMRC Project Grant
UQ Advancing Women Researchers Grant 2015 Round 1 - Dr Christina Schroeder
(2015–2016) UQ Advancing Women Researchers Grants
Development of new anticancer drugs using sortase-mediated ligation
(2013–2015) NHMRC Project Grant
A novel approach to target metastatic tumour cells using a lymphogenic homing peptide
(2013) UQ Early Career Researcher
Development of novel screening tools for peptide modulators of voltage-gated ion channels
Doctor Philosophy — Principal Advisor
Other advisors:
Trefoil factor family: chemical synthesis, mechanisms of action and therapeutic potential for gastrointestinal disorders
Doctor Philosophy — Principal Advisor
Other advisors:
Development of human trefoil factor 3 probes via structure and activity relationship study
Doctor Philosophy — Principal Advisor
Other advisors:
Venoms targeting mosquito-born diseases
Doctor Philosophy — Principal Advisor
Other advisors:
Peptide Engineering: Developing Novel Probes for Voltage Gated Sodium Channels
Doctor Philosophy — Principal Advisor
Other advisors:
Discovery, isolation, characterisation and application of bioactive peptides from tritons
Doctor Philosophy — Associate Advisor
Other advisors:
Voltage-gated sodium channel NaV1.9 as a target for analgesic treatment
Doctor Philosophy — Associate Advisor
Other advisors:
(2019) Doctor Philosophy — Principal Advisor
Other advisors:
Applications of sortase A in disulfide-rich peptide engineering
(2016) Doctor Philosophy — Associate Advisor
Other advisors:
Engineering Cyclotides as Scaffolds for Peptide-Based Drug Design
(2016) Doctor Philosophy — Associate Advisor
Other advisors: