The University of Queensland

EBV-associated primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity

Gandhi, Maher K., Hoang, Thanh, Law, Soi C., Brosda, Sandra, O'Rourke, Kacey, Tobin, Joshua W. D., Vari, Frank, Murigneux, Valentine, Fink, J. Lynn, Gunawardana, Jay, Gould, Clare M., Oey, Harald, Bednarska, Karolina, Delecluse, Susanne, Trappe, Ralf Ulrich, de Long, Lilia Merida, Sabdia, Muhammed Bilal, Bhagat, Govind, Hapgood, Greg, Blyth, Emily, Clancy, Leighton E., Wight, Joel, Hawkes, Eliza A., Rimsza, Lisa M., Maguire, Alanna, Bojarczuk, Kamil, Chapuy, Bjoern and Keane, Colm (2021). EBV-associated primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity. Blood, 137 (11), 1468-1477. doi: 10.1182/blood.2020008520

CD155 on tumor cells drives resistance to immunotherapy by inducing the degradation of the activating receptor CD226 in CD8+ T cells

Braun, Matthias, Aguilera, Amelia Roman, Sundarrajan, Ashmitha, Corvino, Dillon, Stannard, Kimberley, Krumeich, Sophie, Das, Indrajit, Lima, Luize G., Meza Guzman, Lizeth G., Li, Kunlun, Li, Rui, Salim, Nazhifah, Jorge, Maria Villancanas, Ham, Sunyoung, Kelly, Gabrielle, Vari, Frank, Lepletier, Ailin, Raghavendra, Ashwini, Pearson, Sally, Madore, Jason, Jacquelin, Sebastien, Effern, Maike, Quine, Brodie, Koufariotis, Lambros T., Casey, Mika, Nakamura, Kyohei, Seo, Eun Y., Hölzel, Michael, Geyer, Matthias ... Bald, Tobias (2020). CD155 on tumor cells drives resistance to immunotherapy by inducing the degradation of the activating receptor CD226 in CD8+ T cells. Immunity, 53 (4), 805-823.e15. doi: 10.1016/j.immuni.2020.09.010

Targeting an adenosine-mediated “don’t eat me signal” augments anti-lymphoma immunity by anti-CD20 monoclonal antibody

Nakamura, Kyohei, Casey, Mika, Oey, Harald, Vari, Frank, Stagg, John, Gandhi, Maher K. and Smyth, Mark J. (2020). Targeting an adenosine-mediated “don’t eat me signal” augments anti-lymphoma immunity by anti-CD20 monoclonal antibody. Leukemia, 34 (10), 2708-2721. doi: 10.1038/s41375-020-0811-3

EBV-microRNA-BHRF1-2-5p targets the 3'UTR of immune-checkpoint ligands PD-L1 and PD-L2

Cristino, Alexandre S., Nourse, Jamie, West, Rachael A., Sabdia, Muhammed Bilal, Law, Soi C., Gunawardana, Jay, Vari, Frank, Mujaj, Sally, Thillaiyampalam, Gayathri, Snell, Cameron, Gough, Madeline, Keane, Colm and Gandhi, Maher K. (2019). EBV-microRNA-BHRF1-2-5p targets the 3'UTR of immune-checkpoint ligands PD-L1 and PD-L2. Blood, 134 (25), 2261-2270. doi: 10.1182/blood.2019000889

Progression of disease within 24 months in follicular lymphoma is associated with reduced intratumoral immune infiltration

Tobin, Joshua W. D., Keane, Colm, Gunawardana, Jay, Mollee, Peter, Birch, Simone, Hoang, Thanh, Lee, Justina, Li, Li, Huang, Li, Murigneux, Valentine, Fink, J. Lynn, Matigian, Nicholas, Vari, Frank, Francis, Santiyagu, Kridel, Robert, Weigert, Oliver, Haebe, Sarah, Jurinovic, Vindi, Klapper, Wolfram, Steidl, Christian, Sehn, Laurie H., Law, Soi-Cheng, Wykes, Michelle N. and Gandhi, Maher K. (2019). Progression of disease within 24 months in follicular lymphoma is associated with reduced intratumoral immune infiltration. Journal of Clinical Oncology, 37 (34), 3300-3309. doi: 10.1200/JCO.18.02365

Human peripheral blood DNAM-1neg NK cells are a terminally differentiated subset with limited effector functions

Stannard, Kimberley A., Lemoine, Sébastien, Waterhouse, Nigel J., Vari, Frank, Chatenoud, Lucienne, Gandhi, Maher K., Martinet, Ludovic, Smyth, Mark J. and Guillerey, Camille (2019). Human peripheral blood DNAM-1neg NK cells are a terminally differentiated subset with limited effector functions. Blood Advances, 3 (11), 1681-1694. doi: 10.1182/bloodadvances.2018030676

Circulating cell-free miR-494 and miR-21 are disease response biomarkers associated with interim-positron emission tomography response in patients with diffuse large b-cell lymphoma

Cui, Qingyan, Vari, Frank, Cristino, Alexandre S., Salomon, Carlos, Rice, Gregory E., Sabdia, Muhammed B., Guanzon, Dominic, Palma, Carlos, Mathew, Marina, Talaulikar, Dipti, Jain, Sanjiv, Han, Erica, Hertzberg, Mark S., Gould, Clare, Crooks, Pauline, Thillaiyampalam, Gayathri, Keane, Colm and Gandhi, Maher K. (2018). Circulating cell-free miR-494 and miR-21 are disease response biomarkers associated with interim-positron emission tomography response in patients with diffuse large b-cell lymphoma. Oncotarget, 9 (78), 34644-34657. doi: 10.18632/oncotarget.26141

Immune evasion via PD-1/PD-L1 on NK-cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL

Vari, Frank, Arpon, David, Keane, Colm, Hertzberg, Mark S, Talaulikar, Dipti, Jain, Sanjiv, Cui, Qingyan, Han, Erica, Tobin, Josh, Bird, Robert, Cross, Donna, Hernandez, Annette, Gould, Clare, Birch, Simone and Gandhi, Maher K (2018). Immune evasion via PD-1/PD-L1 on NK-cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL. Blood, 131 (16), 1809-1819. doi: 10.1182/blood-2017-07-796342

B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity

McKee, Sara J., Tuong, Zewen K., Kobayashi, Takumi, Doff, Brianna L., Soon, Megan S. F ., Nissen, Michael, Lam, Pui Yeng, Keane, Colm, Vari, Frank, Moi, Davide, Mazzieri, Roberta, Leggatt, Graham, Gandhi, Maher K. and Mattarollo, Stephen R. (2018). B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity. OncoImmunology, 7 (2) e1393599, e1393599. doi: 10.1080/2162402X.2017.1393599

The T-cell receptor repertoire influences the tumor microenvironment and is associated with survival in aggressive B-cell lymphoma

Keane, Colm, Gould, Clare, Jones, Kimberley, Hamm, David, Talaulikar, Dipti, Ellis, Jonathan, Vari, Frank, Birch, Simone, Han, Erica, Wood, Peter, Le-Cao, Kim-Anh, Green, Michael R., Crooks, Pauline, Jain, Sanjiv, Tobin, Josh, Steptoe, Raymond J. and Gandhi, Maher K. (2017). The T-cell receptor repertoire influences the tumor microenvironment and is associated with survival in aggressive B-cell lymphoma. Clinical Cancer Research, 23 (7), 1820-1828. doi: 10.1158/1078-0432.CCR-16-1576

The impact of HLA class I and EBV latency-II antigen-specific CD8+ T cells on the pathogenesis of EBV+ Hodgkin lymphoma

Jones, K., Wockner, L., Brennan, R. M., Keane, C., Chattopadhyay, P. K., Roederer, M., Price, D. A., Cole, D. K., Hassan, B., Beck, K., Gottlieb, D., Ritchie, D. S., Seymour, J. F., Vari, F., Crooks, P., Burrows, S. R. and Gandhi, M. K. (2016). The impact of HLA class I and EBV latency-II antigen-specific CD8+ T cells on the pathogenesis of EBV+ Hodgkin lymphoma. Clinical and Experimental Immunology, 183 (2), 206-220. doi: 10.1111/cei.12716

Ratios of T-cell immune effectors and checkpoint molecules as prognostic biomarkers in diffuse large B-cell lymphoma: a population-based study

Keane, Colm, Vari, Frank, Hertzberg, Mark, Le Cao, Kim-Anh, Green, Michael R., Han, Erica, Seymour, John F., Hicks, Rodney J., Gill, Devinder, Crooks, Pauline, Gould, Clare, Jones, Kimberley, Griffiths, Lyn R., Talaulikar, Dipti, Jain, Sanjiv, Tobin, Josh and Gandhi, Maher K. (2015). Ratios of T-cell immune effectors and checkpoint molecules as prognostic biomarkers in diffuse large B-cell lymphoma: a population-based study. Lancet Haematology, 2 (10), e445-e455. doi: 10.1016/S2352-3026(15)00150-7

A phase I clinical trial of CD1c (BDCA-1)+ dendritic cells pulsed with HLA-A*0201 peptides for immunotherapy of metastatic hormone refractory prostate cancer

Prue, Rebecca L., Vari, Frank, Radford, Kristen J., Tong, Hui, Hardy, Melinda Y., D'Rozario, Rachael, Waterhouse, Nigel J., Rossetti, Tony, Coleman, Robert, Tracey, Christopher, Goossen, Hans, Gounder, Vinay, Crosbie, Georgina, Hancock, Sonia, Diaz-Guilas, Stephanie, Mainwaring, Paul, Swindle, Peter and Hart, Derek N. J. (2015). A phase I clinical trial of CD1c (BDCA-1)+ dendritic cells pulsed with HLA-A*0201 peptides for immunotherapy of metastatic hormone refractory prostate cancer. Journal of Immunotherapy, 38 (2), 71-76. doi: 10.1097/CJI.0000000000000063

A flow cytometry based assay for the enumeration of regulatory T cells in whole blood

Hardy, Melinda Y., Vari, Frank, Rossetti, Tony, Hart, Derek N. and Prue, Rebecca L. (2013). A flow cytometry based assay for the enumeration of regulatory T cells in whole blood. Journal of Immunological Methods, 390 (1-2), 121-126. doi: 10.1016/j.jim.2012.07.004

CD4+Tumor infiltrating lymphocytes are prognostic and independent of R-IPI in patients with DLBCL receiving R-CHOP chemo-immunotherapy

Keane, Colm, Gill, Devinder, Vari, Frank, Cross, Donna, Griffiths, Lynn and Gandhi, Maher (2013). CD4+Tumor infiltrating lymphocytes are prognostic and independent of R-IPI in patients with DLBCL receiving R-CHOP chemo-immunotherapy. American Journal of Hematology, 88 (4), 273-276. doi: 10.1002/ajh.23398

Serum CD163 and TARC as disease response biomarkers in classical Hodgkin lymphoma

Jones, Kimberley, Vari, Frank, Keane, Colm, Crooks, Pauline, Nourse, Jamie P., Seymour, Louise A., Gottlieb, David, Ritchie, David, Gill, Devinder and Gandhi, Maher K. (2013). Serum CD163 and TARC as disease response biomarkers in classical Hodgkin lymphoma. Clinical Cancer Research, 19 (3), 731-742. doi: 10.1158/1078-0432.CCR-12-2693

Back to basics: the complete blood cell count adds to the ability of immunohistochemistry in diffuse large B-cell lymphoma prognosis

Vari, Frank and Gandhi, Maher K. (2012). Back to basics: the complete blood cell count adds to the ability of immunohistochemistry in diffuse large B-cell lymphoma prognosis. Leukemia & Lymphoma, 53 (11), 2097-2098. doi: 10.3109/10428194.2012.701297

Expression profiling of Epstein-Barr virus-encoded microRNAs from paraffin-embedded formalin-fixed primary Epstein-Barr virus-positive B-cell lymphoma samples

Nourse, J.P., Crooks, P., Keane, C.., Nguyen-Van, D., Mujaj, S., Ross, N., Jones, K., Vari, F., Han, E., Trappe, R., Fink, S. and Gandhi, M.K. (2012). Expression profiling of Epstein-Barr virus-encoded microRNAs from paraffin-embedded formalin-fixed primary Epstein-Barr virus-positive B-cell lymphoma samples. Journal of Virological Methods, 184 (1-2), 46-54. doi: 10.1016/j.jviromet.2012.05.005

Human kallikrein 4 signal peptide induces cytotoxic T cell responses in healthy donors and prostate cancer patients

Wilkinson, Ray, Woods, Katherine, D’Rozario, Rachael, Prue, Rebecca, Vari, Frank, Hardy, Melinda Y., Dong, Ying, Clements, Judith A., Hart, Derek N.J. and Radford, Kristen J. (2012). Human kallikrein 4 signal peptide induces cytotoxic T cell responses in healthy donors and prostate cancer patients. Cancer Immunology, Immunotherapy, 61 (2), 169-179. doi: 10.1007/s00262-011-1095-2

Myeloma-Induced Alloreactive T Cells Arising in Myeloma-Infiltrated Bones Include Double-Positive CD8(+)CD4(+) T Cells: Evidence from Myeloma-Bearing Mouse Model

Freeman, Lisa M., Lam, Alfred, Petcu, Eugene, Smith, Robert, Salajegheh, Ali, Diamond, Peter, Zannettino, Andrew, Evdokiou, Andreas, Luff, John, Wong, Pooi-Fong, Khalil, Dalia, Waterhouse, Nigel, Vari, Frank, Rice, Alison M., Catley, Laurence, Hart, Derek N. J. and Vuckovic, Slavica (2011). Myeloma-Induced Alloreactive T Cells Arising in Myeloma-Infiltrated Bones Include Double-Positive CD8(+)CD4(+) T Cells: Evidence from Myeloma-Bearing Mouse Model. Journal of Immunology, 187 (8), 3987-3996. doi: 10.4049/jimmunol.1101202

Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly expresses EBNA3A with conserved CD8 T-cell epitopes

Nguyen-Van, Do, Keane, Colm, Han, Erica, Jones, Kimberley, Nourse, Jamie P., Vari, Frank, Ross, Nathan, Crooks, Pauline, Ramuz, Olivier, Green, Michael, Griffith, Lyn, Trappe, Ralf, Grigg, Andrew, Mollee, Peter and Gandhi, Maher K. (2011). Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly expresses EBNA3A with conserved CD8 T-cell epitopes. American Journal of Blood Research, 1 (2), 146-159.

Broad-spectrum immunosuppression by classless monocytes in non-Hodgkin's lymphoma

Vari, F. and Gandhi, M.K. (2011). Broad-spectrum immunosuppression by classless monocytes in non-Hodgkin's lymphoma. Immunotherapy, 3 (6), 723-726. doi: 10.2217/IMT.11.56

Biological diversity from a structurally diverse library: Systematically scanning conformational space using a pyranose scaffold

Abbenante, Giovanni, Becker, Bernd, Blanc, Sebastien, Clark, Chris, Condie, Glenn, Fraser, Graeme, Grathwohl, Matthias, Halliday, Judy, Henderson, Senka, Lam, Ann, Liu, Ligong, Mann, Maretta, Muldoon, Craig, Pearson, Andrew, Premraj, Rajaratnam, Ramsdale, Tracie, Rossetti, Tony, Schafer, Karl, Le Thanh, Giang, Tometzki, Gerald, Vari, Frank, Verquin, Geraldine, Waanders, Jennifer, West, Michael, Wimmer, Norbert, Yau, Annika, Zuegg, Johannes and Meutermans, Wim (2010). Biological diversity from a structurally diverse library: Systematically scanning conformational space using a pyranose scaffold. Journal of Medicinal Chemistry, 53 (15), 5576-5586. doi: 10.1021/jm1002777

Practical blood dendritic cell vaccination for immunotherapy of multiple myeloma

Vari F, Munster D.J., Hsu J.L., Rossetti T.R., Stephen Mahler, Gray, Peter P., Turtle C.J., Prue R.L. and Hart D.N. (2008). Practical blood dendritic cell vaccination for immunotherapy of multiple myeloma. British Journal Of Haematology, 143 (3), 374-377. doi: 10.1111/j.1365-2141.2008.07346.x

CMRF-56 immunoselected blood dendritic cell preparations activated with GM-CSF induce potent antimyeloma cytotoxic T-cell responses

Freeman, J. L., Vari, F. and Hart, D. N. J. (2007). CMRF-56 immunoselected blood dendritic cell preparations activated with GM-CSF induce potent antimyeloma cytotoxic T-cell responses. Journal of Immunotherapy, 30 (7), 740-748. doi: 10.1097/CJI.0b013e31814fb2d6

Vaccine strategies to treat lymphoproliferative disorders

Radford, Kristen J., Vari, Frank and Hart, Derek N. J. (2005). Vaccine strategies to treat lymphoproliferative disorders. Pathology, 37 (6), 534-550. doi: 10.1080/00313020500376462

Loading DCs with Ag

Vari, F and Hart, DNJ (2004). Loading DCs with Ag. Cytotherapy, 6 (2), 111-121. doi: 10.1080/14653240410005230

Aspects of the Stability and Bioavailability of Carbohydrates and Carbohydrate Derivatives

Drinnan, N. B. and Vari, Frank (2003). Aspects of the Stability and Bioavailability of Carbohydrates and Carbohydrate Derivatives. Mini-Reviews in Medicinal Chemistry, 3 (7), 633-649. doi: 10.2174/1389557033487737

LSF-1 may modulate the indirect allorecognition pathway to delay allograft rejection

Vari, F, Lord, R and Goto, S (2002). LSF-1 may modulate the indirect allorecognition pathway to delay allograft rejection. Transplant Immunology, 10 (4), 259-267. doi: 10.1016/S0966-3274(02)00077-1

Mechanisms of suppression in liver allograft rejection by LSF-1

Goto, S., Vari, F., Lord, R., Edwards-Smith, C., Chiba, S., Kobayashi, S., Pan, T. L., Lin, Y. C., Chiang, K. C., Lai, C. Y., Tatsuma, T., Kitano, S. and Chen, C. L. (1999). Mechanisms of suppression in liver allograft rejection by LSF-1. Transplantation Proceedings, 31 (1-2), 451-452. doi: 10.1016/S0041-1345(98)01702-3

Immunization with a synthetic peptide conjugate derived from the N-terminal sequence of either the beta-chain of haemoglobin or the immunosuppressive protein (reOLT 4) reduces the litter size of pregnant rats

Lord, R, Goto, S, Vari, F, Long-Pan, T, Chiang, KC, Chen, CL and Sunagawa, M (1999). Immunization with a synthetic peptide conjugate derived from the N-terminal sequence of either the beta-chain of haemoglobin or the immunosuppressive protein (reOLT 4) reduces the litter size of pregnant rats. Scandinavian Journal of Immunology, 49 (2), 162-168.

Immunization with a synthetic peptide conjugate derived from the N-terminal sequence of either the beta-chain of haemoglobin or the immunosuppressive protein (reOLT 4) reduces the litter size of pregnant rats

Lord, R., Goto, S., Vari, F., Long-Pan, T., Chiang, K. C., Chen, C. L. and Sunagawa, M. (1999). Immunization with a synthetic peptide conjugate derived from the N-terminal sequence of either the beta-chain of haemoglobin or the immunosuppressive protein (reOLT 4) reduces the litter size of pregnant rats. Scandinavian Journal of Immunology, 49 (2), 162-8. doi: 10.1046/j.1365-3083.1999.00493.x

Antigen presenting cells and chimerism

Lord, R, Vari, F, Goto, S and Sunagawa, M (1998). Antigen presenting cells and chimerism. Transplant Immunology, 6 (1), 61-63. doi: 10.1016/S0966-3274(98)80036-1

Analysis of immunosuppressive proteins in serum of liver-transplanted rats by using an anti-LSF-1 affinity column

Kobayashi, S, Goto, S, Lord, R, Shimizu, Y, Swanson, C, Vari, F, Edwards-Smith, C, Chiba, S, Pan, TL and Chen, CL (1998). Analysis of immunosuppressive proteins in serum of liver-transplanted rats by using an anti-LSF-1 affinity column. Journal of Surgical Research, 80 (1), 58-61. doi: 10.1006/jsre.1998.5327

The characterization of reconstituted passenger leukocytes on the induction of tolerance in rat liver transplantation

Chiba, S, Goto, S, Shimizu, Y, Vari, F, Lord, R, EdwardsSmith, C, Kobayashi, S, Ochiai, T and Isono, K (1997). The characterization of reconstituted passenger leukocytes on the induction of tolerance in rat liver transplantation. Transplant International, 10 (5), 350-356.

Differences in the rate of donor leucocyte migration between natural and drug-assisted tolerance following rat liver transplantation

Lord, R, Goto, S, Vari, F, EdwardsSmith, C, Chiba, S, Sunagawa, M and Lynch, SV (1997). Differences in the rate of donor leucocyte migration between natural and drug-assisted tolerance following rat liver transplantation. Clinical and Experimental Immunology, 108 (2), 358-365. doi: 10.1046/j.1365-2249.1997.d01-1004.x

The characterization of reconstituted passenger leukocytes on the induction of tolerance in rat liver transplantation

Chiba, S., Goto, S., Shimizu, Y., Vari, F., Lord, R., Edwards-Smith, C., Kobayashi, S., Ochiai, T. and Isono, K. (1997). The characterization of reconstituted passenger leukocytes on the induction of tolerance in rat liver transplantation. Transplant International, 10 (5), 350-356. doi: 10.1007/s001470050069

The prevention of graft-versus-host disease by the serum of liver retransplanted rats

Shimizu, Yoshinori, Goto, Shigeru, Vari, Frank, Lord, Roger, Edwards-Smith, Catherine, Chiba, Satoshi, Schlect, D., Buckley, M., Kusano, Mitsuo and Kamada, Naoshi (1997). The prevention of graft-versus-host disease by the serum of liver retransplanted rats. Transplant Immunology, 5 (1), 67-69. doi: 10.1016/S0966-3274(97)80028-7

Restoration of tolerance to rat hepatic allografts by spleen-derived passenger leukocytes

Shimizu, Y, Goto, S, Lord, R, Vari, F, EdwardsSmith, C, Chiba, S, Schlect, D, Buckley, M, Kusano, M and Kamada, N (1996). Restoration of tolerance to rat hepatic allografts by spleen-derived passenger leukocytes. Transplant International, 9 (6), 593-595. doi: 10.1007/BF00335561

The beneficial effect of prostacyclin analogue (OP 2507) on rat liver transplantation subjected to an extended anhepatic phase

Goto, S, Shimizu, Y, Lord, R, Vari, F, EdwardsSmith, C, Chiba, S and Kamada, N (1996). The beneficial effect of prostacyclin analogue (OP 2507) on rat liver transplantation subjected to an extended anhepatic phase. Transplant International, 9 (6), 607-610.

Suppressive effects of serum from liver-transplanted rats against graft-versus-host disease

Enoki, T., Kamada, N., Schlect, D., Buckley, M., Goto, S., Hara, Y., Shimizu, Y., Vari, F., Morita, N. and Esato, K. (1996). Suppressive effects of serum from liver-transplanted rats against graft-versus-host disease. Transplantation Proceedings, 28 (3), 1769-1770.

Novel immunosuppressive proteins purified from the serum of liver-retransplanted rats

Goto, S, Lord, R, Kobayashi, E, Vari, F, EdwardsSmith, C and Kamada, N (1996). Novel immunosuppressive proteins purified from the serum of liver-retransplanted rats. Transplantation, 61 (8), 1147-1151. doi: 10.1097/00007890-199604270-00004

A simplified silver diammine method for the staining of nucleic acids in polyacrylamide gels

Vari, F and Bell, K (1996). A simplified silver diammine method for the staining of nucleic acids in polyacrylamide gels. Electrophoresis, 17 (1), 20-25. doi: 10.1002/elps.1150170104

ORTHOTOPIC LIVER RETRANSPLANTATION IN RATS

GOTO, S, KAMADA, N, DELRIVIERE, L, KOBAYASHI, E, LORD, R, WARE, F, HARA, Y, EDWARDSSMITH, C, SHIMIZU, Y and VARI, F (1995). ORTHOTOPIC LIVER RETRANSPLANTATION IN RATS. Microsurgery, 16 (3), 167-170. doi: 10.1002/micr.1920160310

DEFECTS IN TUMOR-CELL IMMUNOGENICITY - LYMPHOKINE SIGNALS IN INVITRO CYTOLYTIC RESPONSES TO TUMOR ALLOANTIGENS

ASHLEY, MP, KOTLARSKI, and VARI, F (1987). DEFECTS IN TUMOR-CELL IMMUNOGENICITY - LYMPHOKINE SIGNALS IN INVITRO CYTOLYTIC RESPONSES TO TUMOR ALLOANTIGENS. Cellular Immunology, 106 (1), 151-162. doi: 10.1016/0008-8749(87)90158-4

Intra-tumoral CD8+T-cells in follicular lymphoma contain large clonal expansions that are amenable to dual-checkpoint blockade

Nath, Karthik, Law, Soi C., Sabdia, Muhammed B., De Long, Lilia Merida, Shanavas, Mohamed, Tobin, Joshua W. D., Gunawardana, Jay, Vari, Frank, Halliday, Sarah-Jane, Hernandez, Annette, Cross, Donna, Bird, Robert J., Keane, Colm and Gandhi, Maher K. (2019). Intra-tumoral CD8+T-cells in follicular lymphoma contain large clonal expansions that are amenable to dual-checkpoint blockade. 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Orlando, FL, United States, 7 - 10 December 2019. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2019-130050

EBV+ CNS lymphomas have a distinctive tumor microenvironment and genetic profile, which is amenable to combination 3rd party EBV-specific CTL and Ibrutinib therapy

Gandhi, M.K., Hoang, T., Tobin, J.W., Law, S.C., Talaulikar, D., Jain, S., Vari, F., Murigneux, V., Fink, L., Gunawardana, J., Gould, C., Oey, H., Delecluse, S., Trappe, R.U., Merida de Long, L., Sabdia, M.B., Bhagat, G., Hapgood, G., Blyth, E., Clancy, L., Casey, J., Wight, J., Hawkes, E. and Keane, C. (2019). EBV+ CNS lymphomas have a distinctive tumor microenvironment and genetic profile, which is amenable to combination 3rd party EBV-specific CTL and Ibrutinib therapy. 15th International Conference on Malignant Lymphoma, Lugano, Switzerland, 18–22 June 2019. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/hon.91_2629

The tumor microenvironment is independently prognostic of conventional and clinicogenetic risk models in follicular lymphoma

Tobin, Joshua W. D., Keane, Colm, Mollee, Peter, Birch, Simone, Gould, Clare, Gunawardana, Jay, Hoang, Thanh , Ma, Ti, Abro, Emad Uddin, Shanavas, Mohamed, Yoo, Hyung, Li, Li, Scuffham, Paul, Murigneux, Valentine, Fink, Lynn, Matigian, Nicholas, Vari, Frank, Francis, Santiyagu and Gandhi, Maher K. (2017). The tumor microenvironment is independently prognostic of conventional and clinicogenetic risk models in follicular lymphoma. 59th Annual Meeting of the American-Society-of-Hematology (ASH), Atlanta, GA United States, 9-12 December 2017. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood.V130.Suppl_1.728.728

The T-Cell Receptor Repertoire Predicts Interim-PET in Patients with DLBCL Treated with R-CHOP: An Observational Study from a Prospective Clinical Trial

Shanavas, Mohamed, Hertzberg, Mark, Hicks, Rodney J., Seymour, John F., Tobin, Joshua W. D., Mathews, Marina, Francis, Santiyagu, Vari, Frank, Gandhi, Maher K. and Keane, Colm (2017). The T-Cell Receptor Repertoire Predicts Interim-PET in Patients with DLBCL Treated with R-CHOP: An Observational Study from a Prospective Clinical Trial. 59th Annual Meeting of the American-Society-of-Hematology (ASH), Atlanta, GA United States, 9-12 December 2017. Washington, DC United States: American Society of Hematology.

The impact of EBV upon the tumor microenvironment and mutational profile of primary CNS lymphoma in PTLD

Gandhi, Maher K., Keane, Colm, Tobin, Joshua W. D., Talaulikar, Dipti, Jain, Sanjiv, Vari, Frank, Kruze, Lutz, Murigneux, Valentine, Fink, Lynn, Gunawardana, Jithendra, Gould, Clare, Oey, Harold, Fink, Susanne, Trappe, Ralf Ulrich, Mathews, Marina, Francis, Santiyagu and Hoang, Thanh (2017). The impact of EBV upon the tumor microenvironment and mutational profile of primary CNS lymphoma in PTLD. 59th Annual Meeting of the American-Society-of-Hematology (ASH), Atlanta, GA, United States, 9-12 December 2017. Washington, DC, United States: American Society of Hematology.

A Novel Anti-Lymphoma Immune Evasion Mediated By the Interaction Between PD-1 Enriched NK-Cells and CD163+PD-L1+PD-L2+Tumor Associated Macrophages, That Is More Prominent in Hodgkin Lymphoma Than Diffuse Large B-Cell Lymphoma

Gandhi, Maher K., Arpon, David, Keane, Colm, Han, Erica, Tobin, Josh, Bird, Robert, Hertzberg, Mark S., Self, Marlene, Cross, Donna, Hernandez, Annette and Vari, Frank (2016). A Novel Anti-Lymphoma Immune Evasion Mediated By the Interaction Between PD-1 Enriched NK-Cells and CD163+PD-L1+PD-L2+Tumor Associated Macrophages, That Is More Prominent in Hodgkin Lymphoma Than Diffuse Large B-Cell Lymphoma. 58th Annual Meeting and Exposition of the American-Society-of-Hematology, San Diego CA, United States, 3-6 December 2016. Washington, DC United States: American Society of Hematology.

The IRE1/XBP1) pathway is a critical regulatory hub for human NK-cell mediated lysis and motility that modulates the actin-binding protein XIRP1

Gandhi, M. K., Mujaj, S., Vari, F., Cui, Q., Nourse, J. P., Han, E. and Cristino, A. (2016). The IRE1/XBP1) pathway is a critical regulatory hub for human NK-cell mediated lysis and motility that modulates the actin-binding protein XIRP1. International Congress of Immunology (ICI), Melbourne Australia, 21-26 August 2016. Hoboken, NJ United States: Wiley-Blackwell Publishing.

Modulation of the unfolded protein response via XBP1 splicing: a novel mechanism that regulates Natural Killer cell effector function.

Mujaj, Sally, Gandhi, Maher, Vari, Frank and Nourse, Jamie (2012). Modulation of the unfolded protein response via XBP1 splicing: a novel mechanism that regulates Natural Killer cell effector function.. 99th Annual Meeting of the American-Association-of-Immunologists, Boston Ma, May 04-08, 2012. BETHESDA: AMER ASSOC IMMUNOLOGISTS.

Serum CD163 and TARC in Combination As Disease Response Biomarkers in Classical Hodgkin Lymphoma

Gandhi, Maher K., Vari, Frank, Crooks, Pauline, Keane, Colm, Nourse, Jamie P., Seymour, Louise A., Ritchie, David, Gottlieb, David, Gill, Devinder and Jones, Kimberley (2012). Serum CD163 and TARC in Combination As Disease Response Biomarkers in Classical Hodgkin Lymphoma. 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta GA, United States, 8-11 December 2012. Washington, DC United States: American Society of Hematology.

Monocytes Are Associated with Impaired T-Cell Immunity and Residual Interim-PET/CT Avidity After 4 Cycles of CHOP-R In Patients with High-Risk DLBCL

Gandhi, MK, Hertzberg, MS, Han, E, Seymour, JF, Hicks, R, Gill, DS, Keane, C, Crooks, P, Radford, K and Vari, F (2011). Monocytes Are Associated with Impaired T-Cell Immunity and Residual Interim-PET/CT Avidity After 4 Cycles of CHOP-R In Patients with High-Risk DLBCL. 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), San Diego Ca, Dec 10-13, 2011. WASHINGTON: AMER SOC HEMATOLOGY.

Epstein-Barr Virus-specific T Cells as Therapy for Relapsed/Refractory EBV-positive Lymphomas

Jones, Kimberley, Vari, Frank, Khanna, Rajiv, Han, Erica, Singh, Sanjleena, Ritchie, David and Gandhi, Maher K. (2009). Epstein-Barr Virus-specific T Cells as Therapy for Relapsed/Refractory EBV-positive Lymphomas. 24th Annual Meeting of the International-Society-for-Biology-Therapy-of-Cancer, Washington Dc, Oct 29-31, 2009. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.

Mechanisms Underlying the Selective Impairment of Epstein Barr Virus-Nuclear Antigen I-specific Effector T Cells Observed in PTLD

Jones, Kimberley, Nouise, J., Morrison, L., Vari, Frank, Moss, D. and Gandhi, Mahei K. (2009). Mechanisms Underlying the Selective Impairment of Epstein Barr Virus-Nuclear Antigen I-specific Effector T Cells Observed in PTLD. 24th Annual Meeting of the International-Society-for-Biology-Therapy-of-Cancer, Washington Dc, Oct 29-31, 2009. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.

Depletion of host CD122(+) cells facilitates widespread skeletal multiple myeloma engraftment in NOD/SCID recipients

Freeman, Lisa M., Petcu, Eugene, Smith, Robert, Salajegheh, Ali, Diamond, Peter, Zannettino, Andrew Christopher William, Evdokiou, Andreas, Luff, John, Khalil, Dalia, Vari, Frank, Catley, Lawrence, Hart, Derek and Vuckovic, Slavica (2008). Depletion of host CD122(+) cells facilitates widespread skeletal multiple myeloma engraftment in NOD/SCID recipients. 50th Annual Meeting of the American Society of Hematology/ASH/ASCO Joint Symposium, San Francisco Ca, 06-09 December 2008. Washington, DC United States: American Society of Hematology.

Activated CMRF-56 selected blood dendritic cells: A potential anti-myeloma vaccine

Freeman, Jennifer L., Vari, Frank and Hart, Derek N. J. (2007). Activated CMRF-56 selected blood dendritic cells: A potential anti-myeloma vaccine. 49th Annual Meeting of the American-Society-of-Hematology, Atlanta Ga, Dec 08-11, 2007. WASHINGTON: AMER SOC HEMATOLOGY.

Clinical CMRF-56 blood dendritic cell preparations for immunotherapy of multiple myeloma

Vari, Frank, Rossetti, Tony, Freeman, Jennifer and Hart, Derek (2006). Clinical CMRF-56 blood dendritic cell preparations for immunotherapy of multiple myeloma. 48th Annual Meeting of the American-Society-of-Hematology, Orlando Fl, Dec 09-12, 2006. WASHINGTON: AMER SOC HEMATOLOGY.

Characterization of CMRF-56 antibody for isolation of blood dendritic cells for multiple myeloma immunotherapy

Munster, D, Rossetti, T, Pure, R, Vari, F and Hart, D (2006). Characterization of CMRF-56 antibody for isolation of blood dendritic cells for multiple myeloma immunotherapy. 32nd Annual Meeting of the American-Society-for-Blood-and-Marrow-Transplantation, Honolulu Hi, Feb 16-20, 2006. CHARLOTTESVILLE: CARDEN JENNINGS PUBL CO LTD. doi: 10.1016/j.bbmt.2005.11.364

A CMRF-56 blood dendritic cell preparation loaded with control and tumour-associated antigens, for the immune therapy of multiple myeloma: Transition to a phase I clinical trial

Vari, F., Rossetti, T., Prue, R., Mahler, S. and Hart, D.N. (2006). A CMRF-56 blood dendritic cell preparation loaded with control and tumour-associated antigens, for the immune therapy of multiple myeloma: Transition to a phase I clinical trial. x, x, x. United Kingdom: Informa Healthcare.

A phase I clinical trial of a BdCA-1(+) (CD1C(+)) blood dendritic cell preparation loaded with control and tumour-associated antigens, for the immune therapy of metastatic hormone refractory prostate cancer

Prue, R. L., Rossetti, T., Fitzpatrick, S., Vari, F. and Hart, D. N. (2006). A phase I clinical trial of a BdCA-1(+) (CD1C(+)) blood dendritic cell preparation loaded with control and tumour-associated antigens, for the immune therapy of metastatic hormone refractory prostate cancer. OSLO: TAYLOR & FRANCIS AS.

Characterisation of CMRF-56 antibody for process development: Ae clinically applicable system for immunoselection of blood dendritic cells

Munster, D, Rossetti, T, Prue, RL, Vari, F and Hart, D (2005). Characterisation of CMRF-56 antibody for process development: Ae clinically applicable system for immunoselection of blood dendritic cells. 35th Annual SCientific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, Melbourne Australia, Nov 29-Dec 02, 2005. OXFORD: BLACKWELL PUBLISHING.

HLA-DRB1 restriction in the binding of HLA class I allopeptides and correlation with antibody responses

Fuller, TC, Vari, F, Gandee, JM and Fuller, A (1999). HLA-DRB1 restriction in the binding of HLA class I allopeptides and correlation with antibody responses. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00007890-199904150-00078

Cytokine expression in hepatocytes of allografted rat livers

Kobayashi, S, Goto, S, Lord, R, Chiba, S, Vari, F, Okumura, K and Nagaoka, (1998). Cytokine expression in hepatocytes of allografted rat livers. 5th Congress of the Asian-Society-of-Transplantation (CAST), Manila Philippines, Dec 04-07, 1997. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/S0041-1345(98)00898-7

The suppression of heart and liver allograft rejection by liver suppressor factor one (LSF-1) and its possible human homologue

Goto, S, Lord, R, Shimizu, Y, Edwards-Smith, C, Vari, F, Chiba, S, Kobayashi, S, Pan, TL, Akiyama, K, Kuwahara, T, Yuda, H, Goto, T, Chiang, KC, Lin, YC and Chen, CL (1998). The suppression of heart and liver allograft rejection by liver suppressor factor one (LSF-1) and its possible human homologue. 5th Congress of the Asian-Society-of-Transplantation (CAST), Manila Philippines, Dec 04-07, 1997. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/S0041-1345(98)01143-9

Role of reconstituted passenger leukocytes on the induction of tolerance in rat liver transplantation

Chiba, S, Goto, S, Shimizu, Y, Vari, F, Lord, R, EdwardsSmith, C, Ochiai, T and Isono, K (1997). Role of reconstituted passenger leukocytes on the induction of tolerance in rat liver transplantation. XVI International Congress of the Transplantation-Society, Barcelona Spain, Aug 25-30, 1996. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/S0041-1345(96)00505-2

Potential GVHD inhibitory factors in the serum of liver re-transplanted rats

EdwardsSmith, C, Goto, S, Shimizu, Y, Enoki, T, Lord, R, Vari, F, Chiba, S, Schlect, D, Buckley, M and Kamada, N (1997). Potential GVHD inhibitory factors in the serum of liver re-transplanted rats. XVI International Congress of the Transplantation-Society, Barcelona Spain, Aug 25-30, 1996. NEW YORK: Elsevier USA. doi: 10.1016/S0041-1345(96)00167-4

Suppressive effects of serum from liver-transplanted rats against graft-versus-host disease

Enoki, T, Kamada, N, Schlect, D, Buckley, M, Goto, S, Hara, Y, Shimizu, Y, Vari, F, Morita, N and Esato, K (1996). Suppressive effects of serum from liver-transplanted rats against graft-versus-host disease. 4th International Congress of the Asian-Transplantation-Society, Seoul South Korea, Aug 27-30, 1995. NEW YORK: ELSEVIER SCIENCE INC.