Associate Professor Kristen Radford

Honorary Associate Professor

Mater Research Institute-UQ
Faculty of Medicine

Overview

A/Prof Kristen Radford is a Senior Research Fellow and NHMRC CDA Level 2 fellow. She completed her PhD in 1997 from the University of Newcastle, NSW and was awarded NSW Young Australian of the Year in 1998. She then undertook a postdoctoral position at Imperial Cancer Research Fund, London (now Cancer Research UK) developing new dendritic cell-based vaccine strategies for cancer immunotherapy. She joined Mater Research in 2001 and played a key role in obtaining the preclinical data that justified the first blood dendritic cell vaccine trial in prostate cancer that was completed in 2009. Her research interests are focussed on understanding basic dendritic cell biology in humans and applying this knowledge to develop more potent cancer vaccines.

Areas of expertise:

  • human immunology
  • dendritic cells
  • cancer immunology
  • immunotherapy
  • humanised mice

Techniques used / available:

  • humanised mice
  • flow cytometry
  • human immune cell isolation and function
  • human dendritic cell generation

Publications

  • Davies, Julie M., Radford, Kristen J., Begun, Jakob, Levesque, Jean-Pierre and Winkler, Ingrid G. (2021). Adhesion to E-selectin primes macrophages for activation through AKT and mTOR. Immunology and Cell Biology imcb.12447. doi: 10.1111/imcb.12447

  • Lahoud, M. H. and Radford, K. J. (2021). Enhancing the immunogenicity of cancer vaccines by harnessing CLEC9A. Human Vaccines and Immunotherapeutics, 1-5. doi: 10.1080/21645515.2021.1873056

  • Tullett, Kirsteen M., Tan, Peck Szee, Park, Hae-Young, Schittenhelm, Ralf B., Michael, Nicole, Li, Rong, Policheni, Antonia N., Gruber, Emily, Huang, Cheng, Fulcher, Alex J., Danne, Jillian C., Czabotar, Peter E., Wakim, Linda M., Mintern, Justine D., Ramm, Georg, Radford, Kristen J., Caminschi, Irina, O'Keeffe, Meredith, Villadangos, Jose A., Wright, Mark D., Blewitt, Marnie E., Heath, William R., Shortman, Ken, Purcell, Anthony W., Nicola, Nicos A., Zhang, Jian-Guo and Lahoud, Mireille H. (2020). RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells. eLife, 9 e63452, 1-31. doi: 10.7554/eLife.63452

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Supervision

View all Supervision

Publications

Book Chapter

  • Balan, Sreekumar, Radford, Kristen J. and Bhardwaj, Nina (2020). Unexplored horizons of cDC1 in immunity and tolerance. Advances in Immunology. (pp. 49-91) San Diego, CA United States: Academic Press. doi: 10.1016/bs.ai.2020.10.002

  • Macri, Christophe, Fancke, Ben, Radford, Kristen J. and O’Keeffe, Meredith (2019). Monitoring dendritic cell activation and maturation. Antigen Processing. (pp. 403-418) edited by Peter van Endert. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-9450-2_28

  • Lee, Yoke Seng and Radford, Kristen J. (2019). The role of dendritic cells in cancer. International Review of Cell and Molecular Biology. (pp. 123-178) edited by Claire Lhuillier and Lorenzo Galluzzi. Maryland Heights, MO, United States: Academic Press. doi: 10.1016/bs.ircmb.2019.07.006

  • Radford, Kristen J., Shortman, Ken and O'Keefe, Meredith (2013). Dendritic cells in autoimmune disease. The autoimmune diseases. (pp. 175-186) edited by Noel R. Rose and Ian R. Mackay. San Diego, United States: Elsevier. doi: 10.1016/B978-0-12-384929-8.00012-5

  • Kassianos, Andrew J., Jongbloed, Sarah L., Hart, Derek N.J. and Radford, Kristen J. (2010). Isolation of Human Blood DC Subtypes. Dendritic cell protocols. (pp. 45-54) edited by Shalin H. Naik. New York , NY, U.S.A.: Humana Press. doi: 10.1007/978-1-60761-421-0

  • Vulink, A., Radford, K. J., Melief, C. and Hart, D. N. J. (2008). Dendritic Cells in Cancer Immunotherapy. Advances in Cancer Research. (pp. 363-407) London, U.K.: Elsevier Inc.. doi: 10.1016/S0065-230X(07)99006-5

Journal Article

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Completed Supervision