The University of Queensland

Unexplored horizons of cDC1 in immunity and tolerance

Balan, Sreekumar, Radford, Kristen J. and Bhardwaj, Nina (2020). Unexplored horizons of cDC1 in immunity and tolerance. Advances in Immunology. (pp. 49-91) San Diego, CA United States: Academic Press. doi: 10.1016/bs.ai.2020.10.002

Monitoring dendritic cell activation and maturation

Macri, Christophe, Fancke, Ben, Radford, Kristen J. and O’Keeffe, Meredith (2019). Monitoring dendritic cell activation and maturation. Antigen Processing. (pp. 403-418) edited by Peter van Endert. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-9450-2_28

The role of dendritic cells in cancer

Lee, Yoke Seng and Radford, Kristen J. (2019). The role of dendritic cells in cancer. Immunobiology of Dendritic Cells. Part A. (pp. 123-178) edited by Claire Lhuillier and Lorenzo Galluzzi. Cambridge, MA, United States: Academic Press. doi: 10.1016/bs.ircmb.2019.07.006

Dendritic cells in autoimmune disease

Radford, Kristen J., Shortman, Ken and O'Keefe, Meredith (2013). Dendritic cells in autoimmune disease. The autoimmune diseases. (pp. 175-186) edited by Noel R. Rose and Ian R. Mackay. San Diego, United States: Elsevier. doi: 10.1016/B978-0-12-384929-8.00012-5

Isolation of Human Blood DC Subtypes

Kassianos, Andrew J., Jongbloed, Sarah L., Hart, Derek N.J. and Radford, Kristen J. (2010). Isolation of Human Blood DC Subtypes. Dendritic cell protocols. (pp. 45-54) edited by Shalin H. Naik. New York, NY United States: Humana Press. doi: 10.1007/978-1-60761-421-0_3

Dendritic Cells in Cancer Immunotherapy

Vulink, A., Radford, K. J., Melief, C. and Hart, D. N. J. (2008). Dendritic Cells in Cancer Immunotherapy. Advances in Cancer Research. (pp. 363-407) London, U.K.: Elsevier Inc.. doi: 10.1016/S0065-230X(07)99006-5

Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems

Gillespie, Ellen R., Grice, Laura F., Courtney, Isabel G., Lao, Hong Wa, Jung, Woncheol, Ramkomuth, Sonny, Xie, Jacky, Brown, David A., Walsham, James, Radford, Kristen J., Nguyen, Quan H. and Ruitenberg, Marc J. (2024). Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems. Journal of Neuroinflammation, 21 (1) 63, 1-20. doi: 10.1186/s12974-024-03048-0

Exploring NK cell receptor dynamics in paediatric leukaemias: implications for immunotherapy and prognosis

Tu, Cui, Buckle, Irina, Leal Rojas, Ingrid, Rossi, Gustavo Rodrigues, Sester, David P, Moore, Andrew S, Radford, Kristen, Guillerey, Camille and Souza‐Fonseca‐Guimaraes, Fernando (2024). Exploring NK cell receptor dynamics in paediatric leukaemias: implications for immunotherapy and prognosis. Clinical & Translational Immunology, 13 (3) e1501. doi: 10.1002/cti2.1501

Characterization of human engraftment and hemophagocytic lymphohistiocytosis in NSG-SGM3 neonate mice engrafted with purified CD34+ hematopoietic stem cells

Liam, O'Brien, Carina, Walpole, Ingrid, Leal-Rojas, Svetlana, Shatunova, Andrew, Moore, Winkler, Ingrid G, Camille, Guillerey and Radford, Kristen J (2023). Characterization of human engraftment and hemophagocytic lymphohistiocytosis in NSG-SGM3 neonate mice engrafted with purified CD34+ hematopoietic stem cells. Experimental Hematology, 130 104134, 104134. doi: 10.1016/j.exphem.2023.11.008

Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes

Leung, Sherman S., Lenchik, Nataliya, Mathews, Clayton, Pugliese, Alberto, McCarthy, Domenica A., Le Bagge, Selena, Ewing, Adam, Harris, Mark, Radford, Kristen J., Borg, Danielle J., Gerling, Ivan and Forbes, Josephine M. (2023). Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes. Scientific Reports, 13 (1) 12948, 1-15. doi: 10.1038/s41598-023-39243-x

High dimensional analysis reveals distinct NK cell subsets but conserved response to stimulation in umbilical cord blood and adult peripheral blood

Buckle, Irina, Johnson, Anthony, Rojas, Ingrid Leal, Weinert, Vicky, Sester, David P., Radford, Kristen and Guillerey, Camille (2023). High dimensional analysis reveals distinct NK cell subsets but conserved response to stimulation in umbilical cord blood and adult peripheral blood. European Journal of Immunology, 53 (6) 2250118, 1-13. doi: 10.1002/eji.202250118

CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity

Gressier, Elise, Schulte-Schrepping, Jonas, Petrov, Lev, Brumhard, Sophia, Stubbemann, Paula, Hiller, Anna, Obermayer, Benedikt, Spitzer, Jasper, Kostevc, Tomislav, Whitney, Paul G., Bachem, Annabell, Odainic, Alexandru, van de Sandt, Carolien, Nguyen, Thi H. O., Ashhurst, Thomas, Wilson, Kayla, Oates, Clare V. L., Gearing, Linden. J., Meischel, Tina, Hochheiser, Katharina, Greyer, Marie, Clarke, Michele, Kreutzenbeck, Maike, Gabriel, Sarah S., Kastenmüller, Wolfgang, Kurts, Christian, Londrigan, Sarah L., Kallies, Axel, Kedzierska, Katherine ... Bedoui, Sammy (2023). CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity. Nature Immunology, 24 (6), 979-990. doi: 10.1038/s41590-023-01517-x

Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection

Sikder, Md. Al Amin, Rashid, Ridwan B., Ahmed, Tufael, Sebina, Ismail, Howard, Daniel R., Ullah, Md. Ashik, Rahman, Muhammed Mahfuzur, Lynch, Jason P., Curren, Bodie, Werder, Rhiannon B., Simpson, Jennifer, Bissell, Alec, Morrison, Mark, Walpole, Carina, Radford, Kristen J., Kumar, Vinod, Woodruff, Trent M., Ying, Tan Hui, Ali, Ayesha, Kaiko, Gerard E., Upham, John W., Hoelzle, Robert D., Cuív, Páraic Ó., Holt, Patrick G., Dennis, Paul G. and Phipps, Simon (2023). Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection. Immunity, 56 (5), 1098-1114.e10. doi: 10.1016/j.immuni.2023.03.002

The Human Dendritic Cell Atlas: An Integrated Transcriptional Tool to Study Human Dendritic Cell Biology

Elahi, Zahra, Angel, Paul W., Butcher, Suzanne K., Rajab, Nadia, Choi, Jarny, Deng, Yidi, Mintern, Justine D., Radford, Kristen and Wells, Christine A. (2022). The Human Dendritic Cell Atlas: An Integrated Transcriptional Tool to Study Human Dendritic Cell Biology. Journal of Immunology, 209 (12), 2352-2361. doi: 10.4049/jimmunol.2200366

The Human Dendritic Cell Atlas: an integrated transcriptional tool to study human dendritic cell biology

Elahi, Zahra, Angel, Paul W., Butcher, Suzanne K., Rajab, Nadia, Choi, Jarny, Deng, Yidi, Mintern, Justine D., Radford, Kristen and Wells, Christine A. (2022). The Human Dendritic Cell Atlas: an integrated transcriptional tool to study human dendritic cell biology. Journal of Immunology, 209 (12), 2352-2361. doi: 10.4049/jimmunol.2200366

Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells

Leung, Sherman S., Borg, Danielle J., McCarthy, Domenica A., Boursalian, Tamar E., Cracraft, Justen, Zhuang, Aowen, Fotheringham, Amelia K., Flemming, Nicole, Watkins, Thomas, Miles, John J., Groop, Per-Henrik, Scheijen, Jean L., Schalkwijk, Casper G., Steptoe, Raymond J., Radford, Kristen J., Knip, Mikael and Forbes, Josephine M. (2022). Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells. Diabetes, 71 (9), 1994-2008. doi: 10.2337/db22-0177

Discordance in STING-induced activation and cell death between mouse and human dendritic cell populations

Pang, Ee Shan, Daraj, Ghazal, Balka, Katherine R., De Nardo, Dominic, Macri, Christophe, Hochrein, Hubertus, Masterman, Kelly-Anne, Tan, Peck S., Shoppee, Angus, Magill, Zoe, Jahan, Nazneen, Bafit, Mariam, Zhan, Yifan, Kile, Benjamin T., Lawlor, Kate E., Radford, Kristen J., Wright, Mark D. and O'Keeffe, Meredith (2022). Discordance in STING-induced activation and cell death between mouse and human dendritic cell populations. Frontiers in Immunology, 13 794776. doi: 10.3389/fimmu.2022.794776

DROSHA but not DICER is required for human haematopoietic stem cell function

Gu, Karen, Walpole, Carina, Gooneratne, Shayarana, Liu, Xin, Haigh, Oscar L., Radford, Kristen J. and Chong, Mark M. W. (2022). DROSHA but not DICER is required for human haematopoietic stem cell function. Clinical and Translational Immunology, 11 (1) e1361, e1361. doi: 10.1002/cti2.1361

Conventional Type 1 dendritic cells (cDC1) as cancer therapeutics: challenges and opportunities

Johnson, Phillip, Rosendahl, Nikita and Radford, Kristen J. (2021). Conventional Type 1 dendritic cells (cDC1) as cancer therapeutics: challenges and opportunities. Expert Opinion on Biological Therapy, 22 (4), 1-8. doi: 10.1080/14712598.2022.1994943

Cytokines as a marker of central nervous system autoantibody associated epilepsy

Gillinder, Lisa, McCombe, Pamela, Powell, Tamara, Hartel, Gunter, Gillis, David, Rojas, Ingrid Leal and Radford, Kristen (2021). Cytokines as a marker of central nervous system autoantibody associated epilepsy. Epilepsy Research, 176 106708, 1-7. doi: 10.1016/j.eplepsyres.2021.106708

Elucidating the motif for CpG oligonucleotide binding to the dendritic cell receptor DEC-205 leads to improved adjuvants for liver-resident memory

Li, Jessica, Panetta, Fatma, O’Keeffe, Meredith, Leal Rojas, Ingrid M., Radford, Kristen J., Zhang, Jian-Guo, Fernandez-Ruiz, Daniel, Davey, Gayle M., Gully, Benjamin S., Tullett, Kirsteen M., Rossjohn, Jamie, Berry, Richard, Lee, Chin-Nien, Lahoud, Mireille H., Heath, William R. and Caminschi, Irina (2021). Elucidating the motif for CpG oligonucleotide binding to the dendritic cell receptor DEC-205 leads to improved adjuvants for liver-resident memory. The Journal of Immunology, 207 (7), 1836-1847. doi: 10.4049/jimmunol.2001153

T cell expression and release of kidney injury molecule-1 in response to glucose variations initiates kidney injury in early diabetes

Forbes, Josephine M., McCarthy, Domenica A., Kassianos, Andrew J., Baskerville, Tracey, Fotheringham, Amelia J., Giuliani, Kurt T. K., Grivei, Anca, Murphy, Andrew J., Flynn, Michelle C., Sullivan, Mitchell A., Chandrashekar, Preeti, Whiddett, Rani, Radford, Kristen J., Flemming, Nicole, Beard, Sam S., D’Silva, Neisha, Nisbet, Janelle, Morton, Adam, Teasdale, Stephanie, Russell, Anthony, Isbel, Nicole, Jones, Timothy, Couper, Jennifer, Healy, Helen, Harris, Mark, Donaghue, Kim, Johnson, David W., Cotterill, Andrew, Barrett, Helen L. and O’Moore-Sullivan, Trisha (2021). T cell expression and release of kidney injury molecule-1 in response to glucose variations initiates kidney injury in early diabetes. Diabetes, 70 (8), 1754-1766. doi: 10.2337/db20-1081

Activation of stimulator of interferon genes in dendritic cells induces interferon-lambda and subset- and species-specific dendritic cell death

Pang, Ee Shan, Daraj, Ghazal, Macri, Christophe, Balka, Katherine, de Nardo, Dominic, Hochrein, Hubertus, Masterman, Kelly-Anne, Zhan, Yifan, Kile, Benjamin, Lawlor, Kate, Radford, Kristen, Wright, Mark and O’Keeffe, Meredith (2021). Activation of stimulator of interferon genes in dendritic cells induces interferon-lambda and subset- and species-specific dendritic cell death. The Journal of Immunology, 206 (1_Supplement), 111.28-111.28. doi: 10.4049/jimmunol.206.supp.111.28

Adhesion to E-selectin primes macrophages for activation through AKT and mTOR

Davies, Julie M., Radford, Kristen J., Begun, Jakob, Levesque, Jean-Pierre and Winkler, Ingrid G. (2021). Adhesion to E-selectin primes macrophages for activation through AKT and mTOR. Immunology and Cell Biology, 99 (6) imcb.12447, 622-639. doi: 10.1111/imcb.12447

Human CD141+ dendritic cells (cDC1) are impaired in patients with advanced melanoma but can be targeted to enhance anti-PD-1 in a humanized mouse model

Lee, Yoke Seng, O'Brien, Liam J., Walpole, Carina M., Pearson, Frances E., Leal-Rojas, Ingrid M., Masterman, Kelly-Anne, Atkinson, Victoria, Barbour, Andrew and Radford, Kristen J. (2021). Human CD141+ dendritic cells (cDC1) are impaired in patients with advanced melanoma but can be targeted to enhance anti-PD-1 in a humanized mouse model. Journal for ImmunoTherapy of Cancer, 9 (3) e001963, 1-12. doi: 10.1136/jitc-2020-001963

Enhancing the immunogenicity of cancer vaccines by harnessing CLEC9A

Lahoud, M. H. and Radford, K. J. (2021). Enhancing the immunogenicity of cancer vaccines by harnessing CLEC9A. Human Vaccines and Immunotherapeutics, 18 (1) 1873056, 1-5. doi: 10.1080/21645515.2021.1873056

RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

Tullett, Kirsteen M., Tan, Peck Szee, Park, Hae-Young, Schittenhelm, Ralf B., Michael, Nicole, Li, Rong, Policheni, Antonia N., Gruber, Emily, Huang, Cheng, Fulcher, Alex J., Danne, Jillian C., Czabotar, Peter E., Wakim, Linda M., Mintern, Justine D., Ramm, Georg, Radford, Kristen J., Caminschi, Irina, O'Keeffe, Meredith, Villadangos, Jose A., Wright, Mark D., Blewitt, Marnie E., Heath, William R., Shortman, Ken, Purcell, Anthony W., Nicola, Nicos A., Zhang, Jian-Guo and Lahoud, Mireille H. (2020). RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells. eLife, 9 e63452, 1-31. doi: 10.7554/eLife.63452

Human CLEC9A antibodies deliver NY-ESO-1 antigen to CD141+ dendritic cells to activate naïve and memory NY-ESO-1-specific CD8+ T cells

Masterman, Kelly-Anne, Haigh, Oscar L., Tullett, Kirsteen M., Leal-Rojas, Ingrid M., Walpole, Carina, Pearson, Frances E., Cebon, Jonathon, Schmidt, Christopher, O'Brien, Liam, Rosendahl, Nikita, Daraj, Ghazal, Caminschi, Irina, Gschweng, Eric H., Hollis, Roger P., Kohn, Donald B., Lahoud, Mireille H. and Radford, Kristen J. (2020). Human CLEC9A antibodies deliver NY-ESO-1 antigen to CD141+ dendritic cells to activate naïve and memory NY-ESO-1-specific CD8+ T cells. Journal for ImmunoTherapy of Cancer, 8 (2) e000691, 1-11. doi: 10.1136/jitc-2020-000691

Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells

Pearson, Frances E., Tullett, Kirsteen M., Leal-Rojas, Ingrid M., Haigh, Oscar L., Masterman, Kelly-Anne, Walpole, Carina, Bridgeman, John S., McLaren, James E., Ladell, Kristin, Miners, Kelly, Llewellyn-Lacey, Sian, Price, David A., Tunger, Antje, Schmitz, Marc, Miles, John J., Lahoud, Mireille H. and Radford, Kristen J. (2020). Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells. Clinical and Translational Immunology, 9 (6) e1141, e1141. doi: 10.1002/cti2.1141

MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity

Sheng, Yong Hua, Wong, Kuan Yau, Seim, Inge, Wang, Ran, He, Yaowu, Wu, Andy, Patrick, Maya, Lourie, Rohan, Schreiber, Veronika, Giri, Rabina, Ng, Choa Ping, Popat, Amirali, Hooper, John, Kijanka, Gregor, Florin, Timothy H., Begun, Jakob, Radford, Kristen J., Hasnain, Sumaira and McGuckin, Michael A. (2019). MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity. Oncogene, 38 (48), 7294-7310. doi: 10.1038/s41388-019-0951-y

Can Dendritic Cell vaccination prevent leukemia relapse?

O’Brien, Liam J., Guillerey, Camille and Radford, Kristen J. (2019). Can Dendritic Cell vaccination prevent leukemia relapse?. Cancers, 11 (6) 875, 875. doi: 10.3390/cancers11060875

Simple, rapid and inexpensive typing of common HLA class I alleles for immunological studies

Law, Soi Cheng, Haigh, Oscar L., Walpole, Carina M., Keane, Colm, Miles, John, Gandhi, Maher K., Radford, Kristen J. and Steptoe, Raymond J. (2019). Simple, rapid and inexpensive typing of common HLA class I alleles for immunological studies. Journal of Immunological Methods, 465, 72-76. doi: 10.1016/j.jim.2018.12.002

Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR 3 and TLR 7/8 ligation

Pearson, Frances E., Chang, Karshing, Minoda, Yoshihito, Leal Rojas, Ingrid M., Haigh, Oscar L., Daraj, Ghazal, Tullett, Kirsteen M. and Radford, Kristen J. (2018). Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR 3 and TLR 7/8 ligation. Immunology and Cell Biology, 96 (4), 390-400. doi: 10.1111/imcb.12009

Human CD141(+) dendritic cell and CD1c(+) dendritic cell undergo concordant early genetic programming after activation in humanized mice in vivo

Minoda, Yoshihito, Virshup, Isaac, Rojas, Ingrid Leal, Haigh, Oscar, Wong, Yide, Miles, John J., Wells, Christine A. and Radford, Kristen J. (2017). Human CD141(+) dendritic cell and CD1c(+) dendritic cell undergo concordant early genetic programming after activation in humanized mice in vivo. Frontiers in Immunology, 8 (OCT) 1419, 1419. doi: 10.3389/fimmu.2017.01419

Human blood cD1c+ dendritic cells promote Th1 and Th17 effector function in memory cD4+ T cells

Rojas, Ingrid M. Leal, Mok, Wai-Hong, Pearson, Frances E., Minoda, Yoshihito, Kenna, Tony J., Barnard, Ross T. and Radford, Kristen J. (2017). Human blood cD1c+ dendritic cells promote Th1 and Th17 effector function in memory cD4+ T cells. Frontiers in Immunology, 8 (AUG) 971, 971. doi: 10.3389/fimmu.2017.00971

Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+ T cell recognition

Tullett, Kirsteen M., Leal Rojas, Ingrid M., Minoda, Yoshihito, Tan, Peck S., Zhang, Jian-Guo, Smith, Corey, Khanna, Rajiv, Shortman, Ken, Caminschi, Irina, Lahoud, Mireille H. and Radford, Kristen J. (2016). Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+ T cell recognition. JCI Insight, 1 (7) e87102, e87102. doi: 10.1172/jci.insight.87102

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

Beringer, Dennis X., Kleijwegt, Fleur S., Wiede, Florian, Van Der Slik, Arno R., Loh, Khai Lee, Petersen, Jan, Dudek, Nadine L., Duinkerken, Gaby, Laban, Sandra, Joosten, Antoinette, Vivian, Julian P., Chen, Zhenjun, Uldrich, Anthony W., Godfrey, Dale I., McCluskey, James, Price, David A., Radford, Kristen J., Purcell, Anthony W., Nikolic, Tatjana, Reid, Hugh H., Tiganis, Tony, Roep, Bart O. and Rossjohn, Jamie (2015). T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex. Nature Immunology, 16 (11), 1153-1161. doi: 10.1038/ni.3271

Human dendritic cell subsets and function in health and disease

O'Keeffe, Meredith., Mok, Wai Hong. and Radford, Kristen J. (2015). Human dendritic cell subsets and function in health and disease. Cellular and Molecular Life Sciences, 72 (22), 4309-4325. doi: 10.1007/s00018-015-2005-0

Differential use of autophagy by primary dendritic cells specialized in cross-presentation

Mintern, Justine D., Macri, Christophe, Chin, Wei Jin, Panozza, Scott E., Segura, Elodie, Patterson, Natalie L., Zeller, Peter, Bourges, Dorothee, Bedoui, Sammy, McMillan, Paul J., Idris, Adi, Nowell, Cameron J., Brown, Andrew, Radford, Kristen J., Johnston, Angus P. R. and Villadangos, Jose A. (2015). Differential use of autophagy by primary dendritic cells specialized in cross-presentation. Autophagy, 11 (6), 906-917. doi: 10.1080/15548627.2015.1045178

A phase I clinical trial of CD1c (BDCA-1)+ dendritic cells pulsed with HLA-A*0201 peptides for immunotherapy of metastatic hormone refractory prostate cancer

Prue, Rebecca L., Vari, Frank, Radford, Kristen J., Tong, Hui, Hardy, Melinda Y., D'Rozario, Rachael, Waterhouse, Nigel J., Rossetti, Tony, Coleman, Robert, Tracey, Christopher, Goossen, Hans, Gounder, Vinay, Crosbie, Georgina, Hancock, Sonia, Diaz-Guilas, Stephanie, Mainwaring, Paul, Swindle, Peter and Hart, Derek N. J. (2015). A phase I clinical trial of CD1c (BDCA-1)+ dendritic cells pulsed with HLA-A*0201 peptides for immunotherapy of metastatic hormone refractory prostate cancer. Journal of Immunotherapy, 38 (2), 71-76. doi: 10.1097/CJI.0000000000000063

Differential uptake and cross-presentation of soluble and necrotic cell antigen by human DC subsets

Chiang, Meng-Chieh, Tullett, Kirsteen M., Lee, Yoke Seng, Idris, Adi, Ding, Yitian, McDonald, Kylie J., Kassianos, Andrew, Leal Rojas, Ingrid M., Jeet, Varinder, Lahoud, Mireille H. and Radford, Kristen J. (2015). Differential uptake and cross-presentation of soluble and necrotic cell antigen by human DC subsets. European Journal of Immunology, 46 (2), 329-339. doi: 10.1002/eji.201546023

Harnessing human cross-presenting CLEC9A+XCR1+ dendritic cells for immunotherapy

Tullett, Kirsteen M., Lahoud, Mireille H. and Radford, Kristen J. (2014). Harnessing human cross-presenting CLEC9A+XCR1+ dendritic cells for immunotherapy. Frontiers in Immunology, 5 (MAY) Article 239, 1-1. doi: 10.3389/fimmu.2014.00239

Dendritic cells and cancer immunotherapy

Radford, Kristen J., Tullett, Kirsteen M. and Lahoud, Mireille H. (2014). Dendritic cells and cancer immunotherapy. Current Opinion in Immunology, 27 (1), 26-32. doi: 10.1016/j.coi.2014.01.005

FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivo

Ding, Yitian, Wilkinson, Andrew, Idris, Adi, Fancke, Ben, O’Keeffe, Meredith, Khalil, Dalia, Ju, Xinsheng, Lahoud, Mireille H., Caminschi, Irina, Shortman, Ken, Rodwell, Robyn, Vuckovic, Slavica and Radford, Kristen J. (2014). FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivo. Journal of Immunology. doi: 10.4049/jimmunol.1302391

New generation of dendritic cell vaccines

Radford, Kristen J. and Caminschi, Irina (2013). New generation of dendritic cell vaccines. Human Vaccines and Immunotherapeutics, 9 (2), 259-264. doi: 10.4161/hv.22487

Mincle polarizes human monocyte and neutrophil responses to Candida albicans

Vijayan, Dipti, Radford, Kristen J., Beckhouse, Anthony G., Ashman, Robert B. and Wells, Christine A. (2012). Mincle polarizes human monocyte and neutrophil responses to Candida albicans. Immunology and Cell Biology, 90 (9), 889-895. doi: 10.1038/icb.2012.24

Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli

Kassianos, Andrew J., Hardy, Melinda Y., Ju, Xinsheng, Vijayan, Dipti, Ding, Yitian, Vulink, Annelie J. E., McDonald, Kylie J., Jongbloed, Sarah L., Wadley, Robert B., Wells, Christine, Hart, Derek N. J. and Radford, Kristen J. (2012). Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli. European Journal of Immunology, 42 (6), 1512-1522. doi: 10.1002/eji.201142098

Human kallikrein 4 signal peptide induces cytotoxic T cell responses in healthy donors and prostate cancer patients

Wilkinson, Ray, Woods, Katherine, D’Rozario, Rachael, Prue, Rebecca, Vari, Frank, Hardy, Melinda Y., Dong, Ying, Clements, Judith A., Hart, Derek N.J. and Radford, Kristen J. (2012). Human kallikrein 4 signal peptide induces cytotoxic T cell responses in healthy donors and prostate cancer patients. Cancer Immunology, Immunotherapy, 61 (2), 169-179. doi: 10.1007/s00262-011-1095-2

CD34+ cord blood DC-induced antitumor lymphoid cells have efficacy in a murine xenograft model of human ALL

Cullup, Hannah, Hsu, Andy K. W., Kassianos, Andrew J., McDonald, Kylie, Radford, Kristen J. and Rice, Alison M. (2011). CD34+ cord blood DC-induced antitumor lymphoid cells have efficacy in a murine xenograft model of human ALL. Journal of Immunotherapy, 34 (4), 362-371. doi: 10.1097/CJI.0b013e31821b7230

Human CD141(+) (BDCA-3)(+) dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

Jongbloed, Sarah L., Kassianos, Andrew J., McDonald, Kylie J., Clark, Georgina J., Ju, Xinsheng, Angel, Catherine E., Chen, Chun-Jen J., Dunbar, P. Rod, Wadley, obert B., Jeet, Varinder, Vulink, Annelie J.E., Hart, Derek N.J. and Radford, Kristen J. (2010). Human CD141(+) (BDCA-3)(+) dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. Journal of Experimental Medicine, 207 (6), 1247-1260. doi: 10.1084/jem.20092140

NK cells enhance the induction of CTL responses by IL-15 monocyte-derived dendritic cells

Hardy, M., Kassianos, A., Vulink, A., Wilkinson, R., Jongbloed, S. L., Hart, D. N. J. and Radford, K. J. (2009). NK cells enhance the induction of CTL responses by IL-15 monocyte-derived dendritic cells. Immunology and Cell Biology, 87 (8), 606-614. doi: 10.1038/icb.2009.44

Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease: Figure 6

Wilson, John, Cullup, Hannah, Lourie, Rohan, Sheng, Yonghua, Palkova, Anna, Radford, Kristen J., Dickinson, Anne M., Rice, Alison M., Hart, Derek N.J. and Munster, David J. (2009). Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease: Figure 6. The Journal of Experimental Medicine, 206 (5), 1203-1203. doi: 10.1084/jem.20070723041509c

Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease

Wilson, John, Cullup, Hannah, Lourie, Rohan, Sheng, Yonghua, Palkova, Anna, Radford, Kristen J., Dickinson, Anne M., Rice, Alison M., Hart, Derek N. J. and Munster, David J. (2009). Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease. Journal of Experimental Medicine, 206 (2), 387-398. doi: 10.1084/jem.20070723

Blood monocytes, myeloid dendritic cells and the cytokines interleukin (IL)-7 and IL-15 maintain human CD4(+) T memory cells with mixed helper/regulatory function

McKinlay, Adam, Radford, Kristen, Kato, Masato, Field, Ken, Gardiner, Damien, Khalil, Dalia, Burnell, Fiona, Hart, Derek and Vuckovic, Slavica (2007). Blood monocytes, myeloid dendritic cells and the cytokines interleukin (IL)-7 and IL-15 maintain human CD4(+) T memory cells with mixed helper/regulatory function. Immunology, 120 (3), 392-403. doi: 10.1111/j.1365-2567.2006.02515.x

Enhanced delivery of immunoliposomes to human dendritic cells by targeting the multilectin receptor DEC-205

Badiee, A., Davies, N. M., McDonald, K., Radford, K., Michiue, H., Hart, D. and Kato, M. (2007). Enhanced delivery of immunoliposomes to human dendritic cells by targeting the multilectin receptor DEC-205. Vaccine, 25 (25), 4757-4766. doi: 10.1016/j.vaccine.2007.04.029

Numerical and functional assessment of blood dendritic cells in prostate cancer patients

Wilkinson, Ray, Kassianos, Andrew J., Swindle, Peter, Hart, Derek N. J. and Radford, Kristen J. (2006). Numerical and functional assessment of blood dendritic cells in prostate cancer patients. The Prostate, 66 (2), 180-192. doi: 10.1002/pros.20333

CD11c+ blood dendritic cells induce antigen-specific cytotoxic T lymphocytes with similar efficiency compared to monocyte-derived dendritic cells despite higher levels of MHC class I expression

Radford, Kristen J., Turtle, Cameron J., Kassianos, Andrew J. and Hart, Derek N. J. (2006). CD11c+ blood dendritic cells induce antigen-specific cytotoxic T lymphocytes with similar efficiency compared to monocyte-derived dendritic cells despite higher levels of MHC class I expression. Journal of Immunotherapy, 29 (6), 596-605. doi: 10.1097/01.cji.0000211310.90621.5d

Vaccine strategies to treat lymphoproliferative disorders

Radford, Kristen J., Vari, Frank and Hart, Derek N. J. (2005). Vaccine strategies to treat lymphoproliferative disorders. Pathology, 37 (6), 534-550. doi: 10.1080/00313020500376462

Immunoselection of functional CMRF-56+ blood dendritic cells from multiple myeloma patients for immunotherapy

Radford, Kristen J., Turtle, Cameron J., Kassianos, Andrew J., Vuckovic, Slavica, Gardiner, Damien, Khalil, Dahlia, Taylor, Kerry, Wright, Sue, Gill, Devinder and Hart, Derek N. J. (2005). Immunoselection of functional CMRF-56+ blood dendritic cells from multiple myeloma patients for immunotherapy. Journal of Immunotherapy, 28 (4), 322-331. doi: 10.1097/01.cji.0000163592.66910.e4

Potential therapeutic applications of recombinant, invasive E. coli

Critchley, R, Jezzard, S, Radford, KJ, Goussard, S, Lemoine, NR, Grillot-Courvalin, C and Vassaux, G (2004). Potential therapeutic applications of recombinant, invasive E. coli. Gene Therapy, 11 (15), 1224-1233. doi: 10.1038/sj.gt.3302281

Recombinant E. coli efficiently delivers antigen and maturation signals to human dendritic cells: Presentation of MART1 to CD8+ T cells

Radford, KJ, Jackson, AM, Wang, JH, Vassaux, G and Lemoine, NR (2003). Recombinant E. coli efficiently delivers antigen and maturation signals to human dendritic cells: Presentation of MART1 to CD8+ T cells. International Journal of Cancer, 105 (6), 811-819. doi: 10.1002/ijc.11149

A recombinant E. coli vaccine to promote MHC class I-dependent antigen presentation: application to cancer immunotherapy

Radford, K. J., Higgins, D. E., Pasquini, S., Cheadle, E. J., Carta, L., Jackson, A. M., Lemoine, N. R. and Vassaux, G. (2002). A recombinant E. coli vaccine to promote MHC class I-dependent antigen presentation: application to cancer immunotherapy. Gene Therapy, 9 (21), 1455-1463. doi: 10.1038/sj.gt.3301812

Immunogenicity of CD63 in a patient with melanoma

Smith, Melanie, Bleijs, Rik, Radford, Kristen and Mersey, Peter (1997). Immunogenicity of CD63 in a patient with melanoma. Melanoma Research, 7 (SUPPL. 2)

Regulation of tumor cell motility and migration by CD63 in a human melanoma cell line

Radford, KJ, Thorne, RF and Hersey, P (1997). Regulation of tumor cell motility and migration by CD63 in a human melanoma cell line. Journal of Immunology, 158 (7), 3353-3358.

CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with β1 integrins in human melanoma

Radford, KJ, Thorne, RF and Hersey, P (1996). CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with β1 integrins in human melanoma. Biochemical and Biophysical Research Communications, 222 (1), 13-18. doi: 10.1006/bbrc.1996.0690

Suppression of human melanoma cell growth and metastasis by the melanoma-associated antigen CD63 (ME491)

Radford, KJ, Mallesch, J and Hersey, P (1995). Suppression of human melanoma cell growth and metastasis by the melanoma-associated antigen CD63 (ME491). International Journal of Cancer, 62 (5), 631-635. doi: 10.1002/ijc.2910620523

Targeting human CD141+DC using CLEC9A antibodies for cancer immunotherapy

Masterman, K-A., Pearson, F. E., Tullett, K., Haigh, O., Walpole, C., Daraj, G., Lahoud, M. H., Rojas, I. Leal and Radford, K. (2018). Targeting human CD141+DC using CLEC9A antibodies for cancer immunotherapy. ESMO Immuno-Oncology Congress, Geneva Switzerland, Dec 13-16, 2018. OXFORD: OXFORD UNIV PRESS.

Characterising the effects of interferon lambda on dendritic cell function and activation

Pang, E. S., Macri, C., Lundie, R., Pooley, J., Gearing, J., Pupovac, A., Jacobson, K., Hertzog, P., Hochrein, H., Radford, K. and O'Keeffe, M. (2018). Characterising the effects of interferon lambda on dendritic cell function and activation. 15th International Symposium on Dendritic Cells (DC), Aachen Germany, Jun 10-14, 2018. HOBOKEN: WILEY.

Targeting human CD141(+) DC using CLEC9A antibodies for cancer immunotherapy

Pearson, F., Masterman, K. A., Tullett, K., Haigh, O., Walpole, C., Daraj, G., Rojas, Leal, Lahoud, M. H. and Radford, K. (2018). Targeting human CD141(+) DC using CLEC9A antibodies for cancer immunotherapy. 15th International Symposium on Dendritic Cells (DC), Aachen Germany, Jun 10-14, 2018. Hoboken, NJ United States: Wiley.

Characterising the effects of interferon lambda on dendritic cells

Pang, E. S., Macri, C., Pooley, J., Fancke, B., Lundie, R., Hochrein, H., Radford, K. and O'Keeffe, M. (2016). Characterising the effects of interferon lambda on dendritic cells. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL.

Enhanced activation of human CD141(+) DC and CD1c(+) DC in vivo with combined TLR3/TLR8 ligation

Chang, K., Minoda, Y., Leal Rojas, I, Tullett, K. and Radford, K. (2016). Enhanced activation of human CD141(+) DC and CD1c(+) DC in vivo with combined TLR3/TLR8 ligation. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August, 2016. Weinheim, Germany: Wiley.

Human dendritic cell interactions with P-falciparum provide insight into the development of host immunity to malaria

Yap, X. Z., Lundie, R. J., Macri, C. F., Rojas, Leal, I, Feng, G., Radford, K. J., Beeson, J. G. and O'Keeffe, M. (2016). Human dendritic cell interactions with P-falciparum provide insight into the development of host immunity to malaria. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL.

Molecular basis for the efficient processing of antigens taken up by Clec9A, a DAMP receptor on dendritic cells

Tan, P. S., Tullett, K., Park, H-Y, Gruber, E., Radford, K., Nicola, N., Zhang, J-G, Shortman, K., Caminschi, I and Lahoud, M. (2016). Molecular basis for the efficient processing of antigens taken up by Clec9A, a DAMP receptor on dendritic cells. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL.

Targeting CLEC9A can deliver antigen to human CD141(+) DC for recognition by both CD4(+) and CD8(+) T cells

Tullett, K. M., Leal Rojas, I. M., Minoda, Y., Tan, P. S., Zhang, J. -G, Smith, C., Khanna, R., Shortman, K., Caminschi, I, Lahoud, M. H. and Radford, K. J. (2016). Targeting CLEC9A can deliver antigen to human CD141(+) DC for recognition by both CD4(+) and CD8(+) T cells. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August, 2016. Weinheim, Germany: Wiley.

Mobilization of CD8(+) Central Memory T-Cells with Enhanced Reconstitution Potential in Mice By a Combination of G-CSF and GMI-1271-Mediated E-Selectin Blockade

Winkler, Ingrid G., Barbier, Valerie, Radford, Kristen J., Davies, Julie M., Levesque, Jean-Pierre, Smith, Theodore A. G., Fogler, William E. and Magnani, John L. (2015). Mobilization of CD8(+) Central Memory T-Cells with Enhanced Reconstitution Potential in Mice By a Combination of G-CSF and GMI-1271-Mediated E-Selectin Blockade. 57th Annual Meeting of the American Society of Hematology, Orlando, FL United States, 5-8 December 2015. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood.V126.23.512.512

Monocytes Are Associated with Impaired T-Cell Immunity and Residual Interim-PET/CT Avidity After 4 Cycles of CHOP-R In Patients with High-Risk DLBCL

Gandhi, MK, Hertzberg, MS, Han, E, Seymour, JF, Hicks, R, Gill, DS, Keane, C, Crooks, P, Radford, K and Vari, F (2011). Monocytes Are Associated with Impaired T-Cell Immunity and Residual Interim-PET/CT Avidity After 4 Cycles of CHOP-R In Patients with High-Risk DLBCL. 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), San Diego Ca, Dec 10-13, 2011. WASHINGTON: AMER SOC HEMATOLOGY.

CD83 antibody prevents GvHD and does not impair GvL induction

Cullup, H., Wilson, J., Lourie, R., Shen, Y., Palkova, A., Radford, K., Dickinson, A. M., Rice, A., Hart, D. and Munster, D. (2009). CD83 antibody prevents GvHD and does not impair GvL induction. 35th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, Goteborg Sweden, Mar 29-Apr 01, 2009. LONDON: NATURE PUBLISHING GROUP.

Residual lymphocytes in GM-CSF and IL-15 differentiated monocyte-derived dendritic cells enables cytotoxic T lymphocyte responses

Hardy, Melinda Y., Kassianos, Andrew J., Wilkinson, Ray, Vulink, Anneie, Hart, Derek N. J. and Radford, Kristen J. (2007). Residual lymphocytes in GM-CSF and IL-15 differentiated monocyte-derived dendritic cells enables cytotoxic T lymphocyte responses. 49th Annual Meeting of the American-Society-of-Hematology, Atlanta Ga, Dec 08-11, 2007. WASHINGTON: AMER SOC HEMATOLOGY.

Human memory CD4(+) T cells maintained in the absence of antigen develop regulatory T cells capable of suppressing antibody responses

Mckinlay, A, Radford, KJ, Gardiner, D, Khalil, D, Field, K, Burnell, F, Hart, DNJ and Vuckovic, S (2005). Human memory CD4(+) T cells maintained in the absence of antigen develop regulatory T cells capable of suppressing antibody responses. 35th Annual SCientific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, Melbourne Australia, Nov 29-Dec 02, 2005. OXFORD: BLACKWELL PUBLISHING.

Production of IL-2, IL-12, and IL-10 by human blood myeloid dendritic cells

Hardy, MY, Kassianos, AJ, Clark, GJ, Hart, DNJ and Radford, KJ (2005). Production of IL-2, IL-12, and IL-10 by human blood myeloid dendritic cells. 35th Annual SCientific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, Melbourne Australia, Nov 29-Dec 02, 2005. OXFORD: BLACKWELL PUBLISHING.

RNA-loading of CMRF-56 positive blood dendritic cells is a promising strategy for multiple myeloma immunotherapy

Turtle, C. J., Radford, K. J., Allan, C. P., Kassianos, A., Kato, M., Vuckovic, S., MacDonald, K.J., Lopez, Jose A., Jackson, D. C., Wright, S., Taylor, K., Marlton, P., Gill, D., Hart, D. N. J. and Korngold, R. (2004). RNA-loading of CMRF-56 positive blood dendritic cells is a promising strategy for multiple myeloma immunotherapy. Tandem BMT 2004 Meeting, Orlando, Florida, U.S., 13-17 February 2004. CHARLOTTESVILLE: AMER SOC HEMATOLOGY. doi: 10.1016/j.bbmt.2003.12.081

RNA-loading of CMRF-56 positive blood dendritic cells is a promising strategy for multiple myeloma immunotherapy.

Turtle, CJ, Radford, KJ, Allan, CP, Kato, M and Hart, DNJ (2003). RNA-loading of CMRF-56 positive blood dendritic cells is a promising strategy for multiple myeloma immunotherapy.. 45th Annual Meeting of the American-Society-of-Hematology, San Diego California, Dec 06-09, 2003. WASHINGTON: AMER SOC HEMATOLOGY.