Andrew Bartholomaeus, B.Pharm, PhD, Cert Ag (III), obtained a bachelors degree in pharmacy from the University of Sydney and following professional practice in pharmaceutical manufacturing, hospital and military pharmacy completed a PhD in toxicology at RMIT University in Melbourne. Over the past 30 years Prof Bartholomaeus has worked as a toxicologist across a broad range of chemical regulatory areas including agricultural, veterinary and industrial chemicals, complementary medicines, gene technology products and food. Prior to June 2008 he held the position of Chief Toxicologist with the Prescription Medicines area of the Therapeutic Goods Administration in Australia with responsibilities in the area of preclinical assessment and in leading the TGAs response to the Australian National Nanotechnology Strategy. Prof Bartholomaeus subsequently took up the position of General Manager of the Risk Assessment Branch at Food Standards Australia New Zealand. Prof Bartholomaeus retired from FSANZ in 2012 to establish his own consultancy and to devote more time to research and teaching. He currently holds extramural appointments with FSANZ as a science fellow, the University of Queensland Medical School as an Adjunct Professor, the University of Canberra as an Adjunct Professor of Toxicology and Pharmacy, is an expert adviser to the FAO/WHO and was a member of the ILSI IFBiC Steering Group. In June 2009 Dr Bartholomaeus chaired the FAO/WHO Expert consultation on the Application of Nanotechnologies in the Food and Agriculture Sectors: Potential Food Safety Implications. Prof Bartholomaeus is a member of the Society of Toxicology and ACTRA.
Journal Article: Treatment of tungiasis using a tea tree oil-based gel formulation: Protocol for a randomised controlled proof-of-principle trial
Abrha, Solomon, Christenson, Julia K., McEwen, John, Tesfaye, Wubshet, Vaz Nery, Susana, Chang, Aileen Y., Spelman, Tim, Kosari, Sam, Kigen, Gabriel, Carroll, Simon, Heukelbach, Jorg, Feldmeier, Hermann, Bartholomaeus, Andrew, Daniel, Mark, Peterson, Gregory M. and Thomas, Jackson (2021). Treatment of tungiasis using a tea tree oil-based gel formulation: Protocol for a randomised controlled proof-of-principle trial. BMJ Open, 11 (7) e047380. doi: 10.1136/bmjopen-2020-047380
Journal Article: Clinical interventions for tungiasis (sand flea disease): a systematic review
Abrha, Solomon, Heukelbach, Jorg, Peterson, Gregory M, Christenson, Julia K, Carroll, Simon, Kosari, Sam, Bartholomeus, Andrew, Feldmeier, Hermann and Thomas, Jackson (2021). Clinical interventions for tungiasis (sand flea disease): a systematic review. The Lancet Infectious Diseases, 21 (8), e234-e245. doi: 10.1016/S1473-3099(20)30853-7
Journal Article: Mānuka oil—a review of antimicrobial and other medicinal properties
Mathew, Cynthia, Tesfaye, Wubshet, Rasmussen, Phil, Peterson, Gregory M., Bartholomaeus, Andrew, Sharma, Manab and Thomas, Jackson (2020). Mānuka oil—a review of antimicrobial and other medicinal properties. Pharmaceuticals, 13 (11) 343, 1-23. doi: 10.3390/ph13110343
Mechanistic and comparative toxicity of commercial essential oils
(2020–2021) Agrifutures Australia
Mechanistic and comparative toxicity of commercial essential oils
This project will focus on the investigation of endocrine disruption of male reproductive performance by essential oils in experimental animals. The project will start with a literature review on essential oil endocrine disruption, fertility in the male rat, and differences in their reproductive physiology in comparison to other experimental animals and humans. After that, an experimental program will be developed to identify which physiological pathways are disrupted in experimental animals by oregano oil, and other essential oils of similar or overlapping composition.
Regulating Safety of Novel Food and Genetically Modified Crops
Bartholomaeus, Andrew (2018). Regulating Safety of Novel Food and Genetically Modified Crops. Transgenic plants and beyond. (pp. 89-110) Maryland Heights, MO United States: Academic Press. doi: 10.1016/bs.abr.2017.11.003
Hazards of food contact material: nanotechnologies and nanomaterials
Priestly, B. G., Bartholomaeus, A. and Drew, R. (2013). Hazards of food contact material: nanotechnologies and nanomaterials. Encyclopedia of food safety. (pp. 444-448) edited by Yasmine Motarjemi. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/B978-0-12-378612-8.00224-9
Regulating modified-release drug delivery technologies in Australia
Bartholomaeus, Andrew, Rolls, Carolyn and Roberts, Michael S. (2008). Regulating modified-release drug delivery technologies in Australia. Modified-Release Drug Delivery Technology, Second Edition. (pp. 473-485) CRC Press.
Regulatory aspects in modified-release drug delivery
Roberts, Michael S., Bartholomaeus, Andrew, Wade, George, Ghani, Sultan and Marroum, Patrick J. (2008). Regulatory aspects in modified-release drug delivery. Modified-Release Drug Delivery Technology, Second Edition. (pp. 357-383) CRC Press.
Dermal absorption of chemicals: Some australian regulatory considerations
Mueller, Utz, Bartholomaeus, Andrew and Jenner, Mark (2007). Dermal absorption of chemicals: Some australian regulatory considerations. Dermal Absorption and Toxicity Assessment, Second Edition. (pp. 459-470) CRC Press.
Abrha, Solomon, Christenson, Julia K., McEwen, John, Tesfaye, Wubshet, Vaz Nery, Susana, Chang, Aileen Y., Spelman, Tim, Kosari, Sam, Kigen, Gabriel, Carroll, Simon, Heukelbach, Jorg, Feldmeier, Hermann, Bartholomaeus, Andrew, Daniel, Mark, Peterson, Gregory M. and Thomas, Jackson (2021). Treatment of tungiasis using a tea tree oil-based gel formulation: Protocol for a randomised controlled proof-of-principle trial. BMJ Open, 11 (7) e047380. doi: 10.1136/bmjopen-2020-047380
Clinical interventions for tungiasis (sand flea disease): a systematic review
Abrha, Solomon, Heukelbach, Jorg, Peterson, Gregory M, Christenson, Julia K, Carroll, Simon, Kosari, Sam, Bartholomeus, Andrew, Feldmeier, Hermann and Thomas, Jackson (2021). Clinical interventions for tungiasis (sand flea disease): a systematic review. The Lancet Infectious Diseases, 21 (8), e234-e245. doi: 10.1016/S1473-3099(20)30853-7
Mānuka oil—a review of antimicrobial and other medicinal properties
Mathew, Cynthia, Tesfaye, Wubshet, Rasmussen, Phil, Peterson, Gregory M., Bartholomaeus, Andrew, Sharma, Manab and Thomas, Jackson (2020). Mānuka oil—a review of antimicrobial and other medicinal properties. Pharmaceuticals, 13 (11) 343, 1-23. doi: 10.3390/ph13110343
Abrha, Solomon, Bartholomaeus, Andrew, Tesfaye, Wubshet and Thomas, Jackson (2020). Impetigo animal models: a review of their feasibility and clinical utility for therapeutic appraisal of investigational drug candidates. Antibiotics, 9 (10) 694, 1-18. doi: 10.3390/antibiotics9100694
Thomas, Jackson, Davey, Rachel, Peterson, Gregory M., Carson, Christine, Walton, Shelley F., Spelman, Tim, Calma, Tom, Dettwiller, Pascale, Tobin, Jacinta, McMillan, Faye, Collis, Paul, Naunton, Mark, Kosari, Sam, Christenson, Julia K., Bartholomaeus, Andrew, McEwen, John, Fitzpatrick, Peter and Baby, Kavya E. (2018). Treatment of scabies using a tea tree oil-based gel formulation in Australian Aboriginal children: protocol for a randomised controlled trial. BMJ Open, 8 (5) e018507, e018507. doi: 10.1136/bmjopen-2017-018507
Case report of a medication error: in the eye of the beholder
Naunton, Mark, Nor, Kowsar, Bartholomaeus, Andrew, Thomas, Jackson and Kosari, Sam (2016). Case report of a medication error: in the eye of the beholder. Medicine, 95 (28) e4186, e4186. doi: 10.1097/MD.0000000000004186
Genetic basis and detection of unintended effects in genetically modified crop plants
Ladics, Gregory S., Bartholomaeus, Andrew, Bregitzer, Phil, Doerrer, Nancy G., Gray, Alan, Holzhauser, Thomas, Jordan, Mark, Keese, Paul, Kok, Esther, Macdonald, Phil, Parrott, Wayne, Privalle, Laura, Raybould, Alan, Rhee, Seung Yon, Rice, Elena, Romeis, Jorg, Vaughn, Justin, Wal, Jean-Michel and Glenn, Kevin (2015). Genetic basis and detection of unintended effects in genetically modified crop plants. Transgenic Research, 24 (4), 587-603. doi: 10.1007/s11248-015-9867-7
Agricultural biotechnology safety assessment
McClain, Scott, Jones, Wendelyn, He, Xiaoyun, Ladics, Gregory, Bartholomaeus, Andrew, Raybould, Alan, Lutter, Petra, Xu, Haibin and Wang, Xue (2015). Agricultural biotechnology safety assessment. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 49 (1), 78-87.
Bartholomaeus, Andrew, Batista, Juan C.arlos, Burachik, Moisés and Parrott, Wayne (2015). Recommendations from the workshop on comparative approaches to safety assessment of GM plant materials: a road toward harmonized criteria?. GM Crops & Food, 6 (2), 69-79. doi: 10.1080/21645698.2015.1011886
Human pharmacokinetic study of tutin in honey; a plant-derived neurotoxin
Fields, Barry A., Reeve, John, Bartholomaeus, Andrew and Mueller, Utz (2014). Human pharmacokinetic study of tutin in honey; a plant-derived neurotoxin. Food and Chemical Toxicology, 72, 234-241. doi: 10.1016/j.fct.2014.07.032
Measurement of nanomaterials in foods: Integrative consideration of challenges and future prospects
Szakal, Christopher, Roberts, Stephen M., Westerhoff, Paul, Bartholomaeus, Andrew, Buck, Neil, Illuminato, Ian, Canady, Richard and Rogers, Michael (2014). Measurement of nanomaterials in foods: Integrative consideration of challenges and future prospects. ACS Nano, 8 (4), 3128-3135. doi: 10.1021/nn501108g
Bartholomaeus, Andrew, Parrott, Wayne, Bondy, Genevieve and Walker, Kate (2013). The use of whole food animal studies in the safety assessment of genetically modified crops: limitations and recommendations. Critical Reviews in Toxicology, 43 (Supp. 2), 1-24. doi: 10.3109/10408444.2013.842955
Compositional analysis of genetically modified (GM) crops: key issues and future needs
Hoekenga, Owen A., Srinivasan, Jannavi, Barry, Gerard and Bartholomaeus, Andrew (2013). Compositional analysis of genetically modified (GM) crops: key issues and future needs. Journal of Agricultural and Food Chemistry, 61 (35), 8248-8253. doi: 10.1021/jf401141r
Arjo, Gemma, Portero, Manuel, Pinol, Carme, Vinas, Juan, Matias-Guiu, Xavier, Capell, Teresa, Bartholomaeus, Andrew, Parrott, Wayne and Christou, Paul (2013). Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Seralini et al. study claiming that Roundup (TM) Ready corn or the herbicide Roundup (TM) cause cancer in rats. Transgenic Research, 22 (2), 255-267. doi: 10.1007/s11248-013-9692-9
Review of intolerance reactions to food and food additives
Hayder, Hikmat, Mueller, Utz and Bartholomaeus, Andrew (2011). Review of intolerance reactions to food and food additives. International Food Risk Analysis Journal, 1 (2), 23-32.
Review of the toxicology of carbonyl sulfide, a new grain fumigant
Bartholomaeus, Andrew R. and Haritos, Victoria S. (2005). Review of the toxicology of carbonyl sulfide, a new grain fumigant. Food and Chemical Toxicology, 43 (12), 1687-1701. doi: 10.1016/j.fct.2005.06.016
Bartholomaeus, Andrew and Ahokas, Jonna (1995). Inhibition of P-450 by aucubin: is the biological activity of aucubin due to its glutaraldehyde-like aglycone?. Toxicology Letters, 80 (1-3), 75-83. doi: 10.1016/0378-4274(95)03339-M
Inhibition of rat liver cytosolic glutathione s-transferase by silybin
Bartholomaeus, A. R., Bolton, R. and Ahokas, J. T. (1994). Inhibition of rat liver cytosolic glutathione s-transferase by silybin. Xenobiotica, 24 (1), 17-24. doi: 10.3109/00498259409043217
Mechanistic and comparative toxicity of commercial essential oils
(2020–2021) Agrifutures Australia
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
Mechanistic and comparative toxicity of commercial essential oils
This project will focus on the investigation of endocrine disruption of male reproductive performance by essential oils in experimental animals. The project will start with a literature review on essential oil endocrine disruption, fertility in the male rat, and differences in their reproductive physiology in comparison to other experimental animals and humans. After that, an experimental program will be developed to identify which physiological pathways are disrupted in experimental animals by oregano oil, and other essential oils of similar or overlapping composition.