Journal Article: Gene Variants Implicated in Steatotic Liver Disease: Opportunities for Diagnostics and Therapeutics
Huang, Gary, Wallace, Daniel F., Powell, Elizabeth E., Rahman, Tony, Clark, Paul J. and Subramaniam, V. Nathan (2023). Gene Variants Implicated in Steatotic Liver Disease: Opportunities for Diagnostics and Therapeutics. Biomedicines, 11 (10) 2809, 2809. doi: 10.3390/biomedicines11102809
Journal Article: Engineering peptide inhibitors of the HFE–transferrin receptor 1 complex
Goncalves Monteiro, Daniela Goncalves, Rishi, Gautam, Gorman, Declan M., Burnet, Guillaume, Aliyanto, Randy, Rosengren, K. Johan, Frazer, David M., Subramaniam, V. Nathan and Clark, Richard J. (2022). Engineering peptide inhibitors of the HFE–transferrin receptor 1 complex. Molecules, 27 (19) 6581, 1-13. doi: 10.3390/molecules27196581
Journal Article: Cancer: The role of iron and ferroptosis
Rishi, Gautam, Huang, Gary and Subramaniam, V. Nathan (2021). Cancer: The role of iron and ferroptosis. International Journal of Biochemistry and Cell Biology, 141 106094, 106094. doi: 10.1016/j.biocel.2021.106094
Immunotherapeutic Approaches for Hepatocellular Carcinoma
(2014–2019) Gallipoli Medical Research Foundation
(2016) Doctor Philosophy
Transferrin receptor 2 in iron metabolism, its role in liver and extra-hepatic tissue
(2015) Doctor Philosophy
Molecular, cellular and functional characterisation of novel proteasomal proteins hDDI1 and hDDI2
(2012) Doctor Philosophy
Signaling pathways regulating hepcidin
Rishi, Gautam and Subramaniam, V. Nathan (2019). Signaling pathways regulating hepcidin. Iron metabolism: hepcidin. (pp. 47-70) edited by Gerald Litwack. Cambridge, MA United States: Academic Press. doi: 10.1016/bs.vh.2019.01.003
Wallace, Daniel F. and Subramaniam, V. Nathan (2012). Non-HFE Hemochromatosis. Iron Physiology and Pathophysiology in Humans. (pp. 399-416) edited by Gregory J. Anderson and Gordon D. McLaren. New York United States: Humana Press. doi: 10.1007/978-1-60327-485-2_20
Gene Variants Implicated in Steatotic Liver Disease: Opportunities for Diagnostics and Therapeutics
Huang, Gary, Wallace, Daniel F., Powell, Elizabeth E., Rahman, Tony, Clark, Paul J. and Subramaniam, V. Nathan (2023). Gene Variants Implicated in Steatotic Liver Disease: Opportunities for Diagnostics and Therapeutics. Biomedicines, 11 (10) 2809, 2809. doi: 10.3390/biomedicines11102809
Engineering peptide inhibitors of the HFE–transferrin receptor 1 complex
Goncalves Monteiro, Daniela Goncalves, Rishi, Gautam, Gorman, Declan M., Burnet, Guillaume, Aliyanto, Randy, Rosengren, K. Johan, Frazer, David M., Subramaniam, V. Nathan and Clark, Richard J. (2022). Engineering peptide inhibitors of the HFE–transferrin receptor 1 complex. Molecules, 27 (19) 6581, 1-13. doi: 10.3390/molecules27196581
Cancer: The role of iron and ferroptosis
Rishi, Gautam, Huang, Gary and Subramaniam, V. Nathan (2021). Cancer: The role of iron and ferroptosis. International Journal of Biochemistry and Cell Biology, 141 106094, 106094. doi: 10.1016/j.biocel.2021.106094
Baas, Floor S., Rishi, Gautam, Swinkels, Dorine W. and Subramaniam, V. Nathan (2021). Genetic diagnosis in hereditary hemochromatosis: discovering and understanding the biological relevance of variants. Clinical Chemistry, 67 (10), 1324-1341. doi: 10.1093/clinchem/hvab130
Hawula, Zachary J., Davis, Rohan A., Wallace, Daniel F., Rishi, Gautam and Subramaniam, V. Nathan (2021). In vitro identification and characterisation of iron chelating catechol-containing natural products and derivatives. BioMetals, 34 (4), 855-866. doi: 10.1007/s10534-021-00312-1
Crawford, Darrell H.G., Ross, Diana G.F., Jaskowski, Lesley-Anne, Burke, Leslie J., Britton, Laurence J., Musgrave, Nick, Briskey, David, Rishi, Gautam, Bridle, Kim R. and Subramaniam, V. Nathan (2021). Iron depletion attenuates steatosis in a mouse model of non-alcoholic fatty liver disease: Role of iron-dependent pathways. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1867 (7) 166142, 166142. doi: 10.1016/j.bbadis.2021.166142
Milanese, Chiara, Gabriels, Sylvia, Barnhoorn, Sander, Cerri, Silvia, Ulusoy, Ayse, Gornati, S. V., Wallace, Daniel F., Blandini, Fabio, Di Monte, Donato A., Subramaniam, V. Nathan and Mastroberardino, Pier G. (2021). Gender biased neuroprotective effect of Transferrin Receptor 2 deletion in multiple models of Parkinson’s disease. Cell Death and Differentiation, 28 (5), 1720-1732. doi: 10.1038/s41418-020-00698-4
Hepatocyte-specific deletion of peroxisomal protein PEX13 results in disrupted iron homeostasis
Rishi, Gautam, Bhatia, Maneet, Secondes, Eriza S., Melino, Michelle, Crane, Denis and Subramaniam, V. Nathan (2020). Hepatocyte-specific deletion of peroxisomal protein PEX13 results in disrupted iron homeostasis. Biochimica Et Biophysica Acta-Molecular Basis of Disease, 1866 (10) 165882. doi: 10.1016/j.bbadis.2020.165882
Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression
Rishi, Gautam, Secondes, Eriza S., Asplett, Kiran, Wallace, Daniel F., Ostini, Lesa, Berger, Johannes and Subramaniam, V. Nathan (2020). Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression. Bioscience Reports, 40 (8) BSR20201508. doi: 10.1042/bsr20201508
Rishi, Gautam, Secondes, Eriza S., Wallace, Daniel F. and Subramaniam, V. Nathan (2020). Evidence for dimerization of ferroportin in a human hepatic cell line using proximity ligation assays. Bioscience Reports, 40 (5) BSR20191499. doi: 10.1042/bsr20191499
Zhang, Xi, Karunathilaka, Nuwan, Senanayake, Sameera, Subramaniam, V. Nathan, Chan, Wandy, Kostner, Karam, Fraser, John, Atherton, John J. and Punyadeera, Chamindie (2019). Correction to: The potential prognostic utility of salivary galectin-3 concentrations in heart failure (Clinical Research in Cardiology, (2019), 10.1007/s00392-019-01557-0). Clinical Research in Cardiology, 109 (6), 693-693. doi: 10.1007/s00392-019-01583-y
Therapeutic advances in regulating the hepcidin/ferroportin axis
Hawula, Zachary J., Wallace, Daniel F., Subramaniam, V. Nathan and Rishi, Gautam (2019). Therapeutic advances in regulating the hepcidin/ferroportin axis. Pharmaceuticals, 12 (4) 170. doi: 10.3390/ph12040170
The potential prognostic utility of salivary galectin-3 concentrations in heart failure
Zhang, Xi, Karunathilaka, Nuwan, Senanayake, Sameera, Subramaniam, V. Nathan, Chan, Wandy, Kostner, Karam, Fraser, John, Atherton, John J. and Punyadeera, Chamindie (2019). The potential prognostic utility of salivary galectin-3 concentrations in heart failure. Clinical Research in Cardiology, 109 (6), 685-692. doi: 10.1007/s00392-019-01557-0
Cirrhosis in hemochromatosis: independent risk factors in 368 HFE p.C282Y homozygotes
Barton, James C., McLaren, Christine E., Chen, Wen-Pin, Ramm, Grant A., Anderson, Gregory J., Powell, Lawrie W., Subramaniam, V. Nathan, Adams, Paul C., Phatak, Pradyumna D., Gurrin, Lyle C., Phillips, John D., Parker, Charles J., Emond, Mary J. and McLaren, Gordon D. (2018). Cirrhosis in hemochromatosis: independent risk factors in 368 HFE p.C282Y homozygotes. Annals of Hepatology, 17 (5), 871-879. doi: 10.5604/01.3001.0012.3169
Hemochromatosis: Evaluation of the dietary iron model and regulation of hepcidin
Rishi, Gautam, Secondes, Eriza S. and Subramaniam, V. Nathan (2018). Hemochromatosis: Evaluation of the dietary iron model and regulation of hepcidin. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1864 (8), 2550-2556. doi: 10.1016/j.bbadis.2018.05.005
Sandhu, Kam, Flintoff, Kaledas, Chatfield, Mark D., Dixon, Jeannette L., Ramm, Louise E., Ramm, Grant A., Powell, Lawrie W., Subramaniam, V. Nathan and Wallace, Daniel F. (2018). Phenotypic analysis of hemochromatosis subtypes reveals variations in severity of iron overload and clinical disease. Blood, 132 (1), 101-110. doi: 10.1182/blood-2018-02-830562
Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease
Britton, Laurence, Bridle, Kim, Reiling, Janske, Santrampurwala, Nishreen, Wockner, Leesa, Ching, Helena, Stuart, Katherine, Subramaniam, V Nathan, Jeffrey, Gary, St Pierre, Tim, House, Michael, Gummer, Joel, Trengove, Robert, Olynyk, John, Crawford, Darrell and Adams, Leon (2018). Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease. Hepatology Communications, 2 (6), 644-653. doi: 10.1002/hep4.1190
Evaluation of a bone morphogenetic protein 6 variant as a cause of iron loading
McDonald, Cameron J., Rishi, Gautam, Secondes, Eriza S., Ostini, Lesa, Wallace, Daniel F., Crawford, Darrell H. G., Sia, Hanlon, Clark, Paul and Subramaniam, V. Nathan (2018). Evaluation of a bone morphogenetic protein 6 variant as a cause of iron loading. Human Genomics, 12 (1) 23, 23. doi: 10.1186/s40246-018-0155-5
Britton, Laurence, Jaskowski, Lesley-Anne, Bridle, Kim, Secondes, Eriza, Wallace, Daniel, Santrampurwala, Nishreen, Reiling, Janske, Miller, Gregory, Mangiafico, Salvatore, Andrikopoulos, Sofianos, Subramaniam, V. Nathan and Crawford, Darrell (2018). Ferroportin expression in adipocytes does not contribute to iron homeostasis or metabolic responses to a high calorie diet. CMGH, 5 (3), 319-331. doi: 10.1016/j.jcmgh.2018.01.005
Cooray, Shamil D., Heerasing, Neel M., Selkrig, Laura A., Subramaniam, V. Nathan, Hamblin, P. Shane, McDonald, Cameron J., McLean, Catriona A., McNamara, Elissa, Leet, Angeline S. and Roberts, Stuart K. (2018). Reversal of end-stage heart failure in juvenile hemochromatosis with iron chelation therapy: a case report. Journal of Medical Case Reports, 12 (1) 18. doi: 10.1186/s13256-017-1526-6
Iron inhibits the secretion of Apolipoprotein E in cultured human adipocytes
Britton, L. J., Bridle, Kim, Jaskowski, Lesley-Anne, He, Jingjing, Ng, Choaping, Ruelcke, Jayde E., Mohamed, Ahmed, Reiling, Janske, Santrampurwala, Nishreen, Hill, Michelle M., Whitehead, Jonathan P., Subramaniam, V. Nathan and Crawford, Darrell H. G. (2018). Iron inhibits the secretion of Apolipoprotein E in cultured human adipocytes. Cellular and Molecular Gastroenterology and Hepatology, 6 (2), 214-217. doi: 10.1016/j.jcmgh.2018.04.005
The relationship between systemic iron homeostasis and erythropoiesis
Rishi, Gautam and Subramaniam, V. Nathan (2017). The relationship between systemic iron homeostasis and erythropoiesis. Bioscience Reports, 37 (6) BSR20170195, BSR20170195. doi: 10.1042/BSR20170195
Wallace, Daniel F., McDonald, Cameron J., Ostini, Lesa, Iser, David, Tuckfield, Annabel and Subramaniam, V. Nathan (2017). The dynamics of hepcidin-ferroportin internalization and consequences of a novel ferroportin disease mutation. American Journal of Hematology, 92 (10), 1052-1061. doi: 10.1002/ajh.24844
The liver in regulation of iron homeostasis
Rishi, Gautam and Subramaniam, V Nathan (2017). The liver in regulation of iron homeostasis. American Journal of Physiology - Gastrointestinal and Liver Physiology, 313 (3), G157-G165. doi: 10.1152/ajpgi.00004.2017
Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice
Heritage, Mandy, Jaskowski, Lesley, Bridle, Kim, Campbell, Catherine, Briskey, David, Britton, Laurence, Fletcher, Linda, Vitetta, Luis, Subramaniam, V. Nathan and Crawford, Darrell (2017). Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice. World Journal of Gastrointestinal Pathophysiology, 8 (2), 67-76. doi: 10.4291/wjgp.v8.i2.67
McLaren, Gordon D., Barton, James C., Ramm, Grant A., Emond, Mary J., Subramaniam, V. Nathan, Phatak, Pradyumna D., Adams, Paul C., Powell, Lawrie W., Gurrin, Lyle C., Anderson, Gregory J. and McLaren, Christine E. (2017). GNPAT Polymorphism rs11558492 Is Not Associated With Increased Severity in a Large Cohort of HFE p.Cys282Tyr Homozygous Patients REPLY. Hepatology, 65 (3), 1072-1073. doi: 10.1002/hep.29002
Barton, James C., Chen, Wen-pin, Emond, Mary J., Phatak, Pradyumna D., Subramaniam, V. Nathan, Adams, Paul C., Gurrin, Lyle C., Anderson, Gregory J., Ramm, Grant A., Powell, Lawrie W., Allen, Katrina J., Phillips, John D., Parker, Charles J., McLaren, Gordon D. and McLaren, Christine E. (2017). GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes. Blood Cells, Molecules and Diseases, 63, 15-20. doi: 10.1016/j.bcmd.2016.11.009
The functional roles of T-cadherin in mammalian biology
Sternberg, Jade, Wankell, Miriam, Subramaniam, V. Nathan and Hebbard, Lionel W. (2017). The functional roles of T-cadherin in mammalian biology. AIMS Molecular Science, 4 (1), 62-81. doi: 10.3934/molsci.2017.1.62
Subramaniam, V. Nathan (2017). Ironing out Steatohepatitis. Annals of Hepatology, 16 (1), 8-9. doi: 10.5604/16652681.1226809
Mcdonald, Cameron J., Rishi, Gautam, Wallace, Daniel F. and Subramaniam, V. Nathan (2016). Genetic variants in the BMP6 pro-peptide may not cause iron loading and should be interpreted with caution. Gastroenterology, 151 (4), 770-771. doi: 10.1053/j.gastro.2016.03.053
Iron and non-alcoholic fatty liver disease
Britton, Laurence J., Subramaniam, V. Nathan and Crawford, Darrell H. G. (2016). Iron and non-alcoholic fatty liver disease. World Journal of Gastroenterology, 22 (36), 8112-8122. doi: 10.3748/wjg.v22.i36.8112
Rishi, Gautam, Secondes, Eriza S., Wallace, Daniel F. and Subramaniam, V. Nathan (2016). Hematopoietic deletion of transferrin receptor 2 in mice leads to a block in erythroid differentiation during iron-deficient anemia. American Journal of Hematology, 91 (8), 812-818. doi: 10.1002/ajh.24417
Pocket-sized iron regulators: One size fits all?
Subramaniam, V. Nathan (2016). Pocket-sized iron regulators: One size fits all?. Blood, 128 (2), 153-154. doi: 10.1182/blood-2016-05-716043
Probiotics modify tight-junction proteins in an animal model of nonalcoholic fatty liver disease
Briskey, David, Heritage, Mandy, Jaskowski, Lesley-Anne, Peake, Jonathan, Gobe, Glenda, Subramaniam, V. Nathan, Crawford, Darrell, Campbell, Catherine and Vitetta, Luis (2016). Probiotics modify tight-junction proteins in an animal model of nonalcoholic fatty liver disease. Therapeutic Advances in Gastroenterology, 9 (4), 463-472. doi: 10.1177/1756283X16645055
Britton, Laurence, Jaskowski, Lesley, Bridle, Kim, Santrampurwala, Nishreen, Reiling, Janske, Musgrave, Nick, Subramaniam, V. Nathan and Crawford, Darrell (2016). Heterozygous Hfe gene deletion leads to impaired glucose homeostasis, but not liver injury in mice fed a high-calorie diet. Physiological Reports, 4 (12) e12837, e12837. doi: 10.14814/phy2.12837
GNPAT variant is not associated with severe iron overload in Irish C282Y homozygotes REPLY
McLaren, Christine E., Barton, James C., Phatak, Pradyumna D., Emond, Mary J., Subramaniam, V. Nathan, Gurrin, Lyle C., Adams, Paul C., Powell, Lawrie W., Ramm, Grant A., Anderson, Gregory J. and McLaren, Gordon D. (2016). GNPAT variant is not associated with severe iron overload in Irish C282Y homozygotes REPLY. Hepatology, 63 (6), 2056-2057. doi: 10.1002/hep.28260
McLaren, Christine E., Barton, James C., Subramaniam, V. Nathan, Ramm, Grant A., Phatak, Pradyumna D., Emond, Mary J., Gurrin, Lyle C., Adams, Paul C., Powell, Lawrie W., Anderson, Gregory J. and McLaren, Gordon D. (2016). Reply. Hepatology, 63 (6), 2058-2060. doi: 10.1002/hep.28479
Wallace, Daniel F. and Subramaniam, V. Nathan (2016). The global prevalence of HFE and non-HFE hemochromatosis estimated from analysis of next-generation sequencing data. Genetics in Medicine, 18 (6), 618-626. doi: 10.1038/gim.2015.140
Kalinowski, Danuta S., Stefani, Christian, Toyokuni, Shinya, Ganz, Tomas, Anderson, Gregory J., Subramaniam, Nathan V., Trinder, Debbie, Olynyk, John K., Chua, Anita, Jansson, Patric J., Sahni, Sumit, Lane, Darius J. R., Merlot, Angelica M., Kovacevic, Zaklina, Huang, Michael L. H., Lee, C. Soon and Richardson, Des R. (2016). Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1863 (4), 727-748. doi: 10.1016/j.bbamcr.2016.01.026
Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2
Rishi,Gautam, Secondes, Eriza S., Wallace, Daniel F. and Subramaniam, V. Nathan (2016). Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2. American Journal of Physiology - Gastrointestinal and Liver Physiology, 310 (3), G171-G180. doi: 10.1152/ajpgi.00291.2015
Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin
Goh, Justin B., Wallace, Daniel F., Hong, Wanjin and Subramaniam, V. Nathan (2015). Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin. Scientific Reports, 5 (1) 13986, 13986.1-13986.12. doi: 10.1038/srep13986
McLaren, Christine E., Emond, Mary J., Subramaniam, V. Nathan, Phatak, Pradyumna D., Barton, James C., Adams, Paul C., Goh, Justin B., McDonald, Cameron J., Powell, Lawrie W., Gurrin, Lyle C., Allen, Katrina J., Nickerson, Deborah A., Louie, Tin, Ramm, Grant A., Anderson, Gregory J. and McLaren, Gordon D. (2015). Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload. Hepatology, 62 (2), 429-439. doi: 10.1002/hep.27711
Next-generation sequencing: Application of a novel platform to analyze atypical iron disorders
McDonald, Cameron J., Ostini, Lesa., Wallace, Daniel F., Lyons, Alison., Crawford, Darrell H.G. and Subramaniam, V. Nathan. (2015). Next-generation sequencing: Application of a novel platform to analyze atypical iron disorders. Journal of Hepatology, 63 (5), 1288-1293. doi: 10.1016/j.jhep.2015.06.027
Wallace, Daniel F. and Subramaniam, V. Nathan (2015). Analysis of IL-22 contribution to hepcidin induction and hypoferremia during the response to LPS in vivo. International Immunology, 27 (6), 281-287. doi: 10.1093/intimm/dxu144
McDonald, Cameron J., Ostini, Lesa, Bennett, Nigel, Subramaniam, Nanthakumar, Hooper, John, Velasco, Gloria, Wallace, Daniel F. and Nathan Subramaniam, V. (2015). Functional analysis of matriptase-2 mutations and domains: Insights into the molecular basis of iron-refractory iron deficiency anemia. American Journal of Physiology - Cell Physiology, 308 (7), C539-C547. doi: 10.1152/ajpcell.00264.2014
Bridle, Kim R., Sobbe, Amy L., de Guzman, C. Erika, Santrampurwala, Nishreen, Jaskowski, Lesley A., Clouston, Andrew D., Campbell, Catherine M., Nathan Subramaniam, V. and Crawford, Darrell H. G. (2015). Lack of efficacy of mTOR inhibitors and ACE pathway inhibitors as antifibrotic agents in evolving and established fibrosis in Mdr2-/- mice. Liver International, 35 (4), 1451-1463. doi: 10.1111/liv.12494
A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction
Wallace, Daniel F., Secondes, Eriza S., Rishi, Gautam, Ostini, Lesa, McDonald, Cameron J., Lane, Steven W., Vu, Therese, Hooper, John D., Velasco, Gloria, Ramsay, Andrew J., Lopez-Otin, Carlos and Subramaniam, V. Nathan (2015). A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction. British Journal of Haematology, 168 (6), 891-901. doi: 10.1111/bjh.13225
Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox
Sobbe, Amy, Bridle, Kim R., Jaskowski, Lesley, de Guzman, C. Erika, Santrampurwala, Nishreen, Clouston, Andrew D., Campbell, Catherine M., Subramaniam, V. Nathan and Crawford, Darrell H. G. (2015). Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox. Journal of Gastroenterology and Hepatology, 30 (3), 638-645. doi: 10.1111/jgh.12720
Mclaren, Christine E., Emond, Mary J., Subramaniam, V. Nathan, Phatak, Pradyumna D., Barton, James C., Adams, Paul C., Powell, Lawrie W., Gurrin, Lyle C., Ramm, Grant A., Anderson, Gregory J. and Mclaren, Gordon D. (2015). Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload. Hepatology, 62 (6), 1918-1919. doi: 10.1002/hep.27851
Hepcidin: Regulation of the master iron regulator
Rishi, Gautam, Wallace, Daniel F. and Subramaniam, V. Nathan (2015). Hepcidin: Regulation of the master iron regulator. Bioscience Reports, 35 (3) e00192, e00192-e00192. doi: 10.1042/BSR20150014
Linking hypoxia and iron homeostasis: a 'plate' full of factors
Subramaniam, V. Nathan and Wallace, Daniel F. (2014). Linking hypoxia and iron homeostasis: a 'plate' full of factors. Gut, 63 (12), 1840-1842. doi: 10.1136/gutjnl-2014-306970
McDonald, Cameron J., Wallace, Daniel F., Ostini, Lesa and Subramaniam, V. Nathan (2014). Parenteral vs. oral iron: influence on hepcidin signaling pathways through analysis of Hfe/Tfr2-null mice. American Journal of Physiology: Gastrointestinal and Liver Physiology, 306 (2), G132-G139. doi: 10.1152/ajpgi.00256.2013
Wood, Marnie J, Powell, Lawrie W, Dixon, Jeannette L, Subramaniam, V. Nathan and Ramm, Grant A (2013). Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis. World Journal of Gastroenterology, 19 (48), 9366-9376. doi: 10.3748/wjg.v19.i48.9366
Tan, Terrence C. H., Crawford, Darrell H. G., Jaskowski, Lesley A., Murphy, Therese L., Santrampurwala, Nishreen, Crane, Denis, Clouston, Andrew D., Subramaniam, V. Nathan, Anderson, Gregory J. and Fletcher, Linda M. (2013). A corn oil-based diet protects against combined ethanol and iron-induced liver injury in a mouse model of hemochromatosis. Alcoholism-Clinical and Experimental Research, 37 (10), 1619-1631. doi: 10.1111/acer.12155
Rishi, Gautam, Crampton, Emily M., Wallace, Daniel F. and Subramaniam, V. Nathan (2013). In situ proximity ligation assays indicate that hemochromatosis proteins Hfe and transferrin receptor 2 (Tfr2) do not interact. PLoS One, 8 (10) e77267, e77267.1-e77267.11. doi: 10.1371/journal.pone.0077267
Transthyretin-thyroid hormone internalization by trophoblasts
Landers, K. A., Li, H., Subramaniam, V. N., Mortimer, R. H. and Richard, K. (2013). Transthyretin-thyroid hormone internalization by trophoblasts. Placenta, 34 (8), 716-718. doi: 10.1016/j.placenta.2013.05.005
Iron storage disease in Asia-Pacific populations: the importance of non-HFE mutations
McDonald, Cameron J., Wallace, Daniel F., Crawford, Darrell H. G. and Subramaniam, V. Nathan (2013). Iron storage disease in Asia-Pacific populations: the importance of non-HFE mutations. Journal of Gastroenterology and Hepatology, 28 (7), 1087-1094. doi: 10.1111/jgh.12222
Oancea, Iulia, Png, Chin Wen, Das, Indrajit, Lourie, Rohan, Winkler, Ingrid G., Eri, Rajaraman, Subramaniam, Nathan, Jinnah, H. A., McWhinney, Brett C., Levesque, Jean-Pierre, McGuckin, Michael A., Duley, John A. and Florin, Timothy H. J. (2013). A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity. Gut, 62 (4), 594-605. doi: 10.1136/gutjnl-2012-302274
Jeffery, Jessie M., Grigoriev, Ilya, Poser, Ina, van der Horst, Armando, Hamilton, Nicholas, Waterhouse, Nigel, Bleier, Jonathan, Subramaniam, V. Nathan, Maly, Ivan V., Akhmanova, Anna and Khanna, Kum Kum (2013). Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitment. Cell Cycle, 12 (6), 899-906. doi: 10.4161/cc.23879
Tan, Terrence C. H., Crawford, Darrell H. G., Jaskowski, Lesley A., Subramaniam,V. Nathan, Clouston, Andrew D., Crane, Denis I., Bridle, Kim R., Anderson, Gregory J. and Fletcher, Linda M. (2013). Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury. Laboratory Investigation, 93 (12), 1295-1312. doi: 10.1038/labinvest.2013.121
Subramaniam, V. Nathan, McDonald, Cameron J., Ostini, Lesa, Lusby, Patricia E., Wockner, Leesa F., Ramm, Grant A. and Wallace, Daniel F. (2012). Hepatic Iron Deposition Does Not Predict Extrahepatic Iron Loading in Mouse Models of Hereditary Hemochromatosis. American Journal of Pathology, 181 (4), 1173-1179. doi: 10.1016/j.ajpath.2012.06.025
Iron predicts tolerance in liver transplantation
Wallace, Daniel F., Crawford, Darrell H. G. and Subramaniam, V. Nathan (2012). Iron predicts tolerance in liver transplantation. Gastroenterology, 143 (3), 862-865. doi: 10.1053/j.gastro.2012.07.091
The control of iron homeostasis: MICRORNAS join the party
Wallace, Daniel F., Crawford, Darrell H.G. and Subramaniam, V. Nathan (2011). The control of iron homeostasis: MICRORNAS join the party. Gastroenterology, 141 (4), 1520-1522. doi: 10.1053/j.gastro.2011.08.018
Iron loading and oxidative stress in the Atm(-/-) mouse liver
McDonald, Cameron J., Ostini, Lesa, Wallace, Daniel F., John, Abraham N., Watters, Dianne J. and Subramaniam, V. Nathan (2011). Iron loading and oxidative stress in the Atm(-/-) mouse liver. American Journal of Physiology: Gastrointestinal and Liver Physiology, 300 (4), G554-G560. doi: 10.1152/ajpgi.00486.2010
Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2
Wallace, Daniel F., McDonald, Cameron J., Ostini, Lesa and Subramaniam, V. Nathan (2011). Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2. Blood, 117 (10), 2960-2966. doi: 10.1182/blood-2010-08-303859
McDonald, Cameron J., Wallace, Daniel F., Ostini, Lesa, Bell, Sally J., Demediuk, Barbara and Subramaniam, V. Nathan (2011). G80S-linked ferroportin disease: Classical ferroportin disease in an Asian family and reclassification of the mutant as iron transport defective. Journal of Hepatology, 54 (3), 538-544. doi: 10.1016/j.jhep.2010.07.048
Altered Lipid Metabolism in Hfe-Knockout Mice Promotes Severe NAFLD and Early Fibrosis
Tan, Terrence C.H., Crawford, Darrell H.G., Jaskowski, Lesley A., Murphy, Therese M., Heritage, Mandy L., Subramaniam, V. Nathan, Clouston, Andrew D., Anderson, Gregory J. and Fletcher, Linda M. (2011). Altered Lipid Metabolism in Hfe-Knockout Mice Promotes Severe NAFLD and Early Fibrosis. American Journal of Physiology: Gastrointestinal and Liver Physiology, 301 (5), 1-39. doi: 10.1152/ajpgi.00150.2011
Syntaxin 5 is required for copper homeostasis in Drosophila and mammals
Norgate, Melanie, Southon, Adam, Greenough, Mark, Cater, Michael, Farlow, Ashley, Batterham, Philip, Bush Ashley I., Subramaniam, V. Nathan, Burke, Richard and Camakaris, James (2010). Syntaxin 5 is required for copper homeostasis in Drosophila and mammals. PLoS One, 5 (12) e14303, e14303-1-e14303-10. doi: 10.1371/journal.pone.0014303
Transferrin receptor 1: A ferritin receptor as well?
Wallace, Daniel F., McDonald, Cameron and Subramaniam, V. Nathan (2010). Transferrin receptor 1: A ferritin receptor as well?. Gastroenterology, 139 (3), 1052-1053. doi: 10.1053/j.gastro.2010.07.030
Centrobin regulates the assembly of functional mitotic spindles
Jeffery, J. M., Urquhart, A. J., Subramaniam, V. N., Parton, R.G. and Khanna, K.K. (2010). Centrobin regulates the assembly of functional mitotic spindles. Oncogene, 29 (18), 2649-2658. doi: 10.1038/onc.2010.37
McDonald, Cameron J., Jones, Malcolm K., Wallace, Daniel F., Summerville, Lesa, Nawaratna, Sujeevi and Subramaniam, V. Nathan (2010). Increased iron stores correlate with worse disease outcomes in a mouse model of schistosomiasis infection. PLoS One, 5 (3) e9594, 1-7. doi: 10.1371/journal.pone.0009594
Wallace, Daniel F., Harris, Jonathan M. and Subramaniam, V. Nathan (2010). Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype. American Journal of Physiology: Cell Physiology, 298 (1), C75-C84. doi: 10.1152/ajpcell.00621.2008
Wallace, Daniel F., Summerville, Lesa, Crampton, Emily M., Frazer, David M., Anderson, Gregory J. and Subramaniam, V. Nathan (2009). Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology, 50 (6), 1992-2000. doi: 10.1002/hep.23198
Carrier-Mediated Thyroid Hormone Transport into Placenta by Placental Transthyretin
Landers, Kelly A., McKinnon, Brett D., Li, Huika, Subramaniam, V. Nathan, Mortimer, Robin H. and Richard, Kerry (2009). Carrier-Mediated Thyroid Hormone Transport into Placenta by Placental Transthyretin. Journal of Clinical Endocrinology and Metabolism, 94 (7), 2610-2616. doi: 10.1210/jc.2009-0048
Co-factors in liver disease: The role of HFE-related hereditary hemochromatosis and iron
Wallace, Daniel F. and Subramaniam, V. Nathan (2009). Co-factors in liver disease: The role of HFE-related hereditary hemochromatosis and iron. Biochimica et Biophysica Acta - General Subjects, 1790 (7), 663-670. doi: 10.1016/j.bbagen.2008.09.002
Hepcidin Regulation by HFE and TFR2: Is It Enough to Give a Hepatocyte a Complex?
Wallace, Daniel F., Trinder, Debbie and Subramaniam, V. Nathan (2009). Hepcidin Regulation by HFE and TFR2: Is It Enough to Give a Hepatocyte a Complex?. Gastroenterology, 137 (3), 1173-1175. doi: 10.1053/j.gastro.2009.07.009
Ramm, Grant A., Ruddell, Richard G. and Subramaniam, V. Nathan (2009). Identification of Ferritin Receptors: Their Role in Iron Homeostasis, Hepatic Injury, and Inflammation. Gastroenterology, 137 (5), 1849-1851. doi: 10.1053/j.gastro.2009.09.037
Ruddell, Richard G., Knight, Belinda, Tirnitz-Parker, Janina E. E., Akhurst, Barbara, Summerville, Lesa, Subramaniam, V. Nathan, Olynyk, John K. and Ramm, Grant A. (2009). Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury. Hepatology, 49 (1), 227-239. doi: 10.1002/hep.22597
Regulation of Iron Homeostasis: Is It All in the HBD?
Subramaniam, V. Nathan (2009). Regulation of Iron Homeostasis: Is It All in the HBD?. Gastroenterology, 136 (4), 1449-1451. doi: 10.1053/j.gastro.2009.02.034
Crawford, D. H. G., Murphy, T. L., Ramm, L. E., Fletcher, L. M., Clouston, AD, Anderson, G. J., Subramaniam, V. N., Powell, L. W. and Ramm, G. A. (2009). Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis. Hepatology, 49 (2), 418-425. doi: 10.1002/hep.22650
Juvenile iron overload: Advances, but no answers
Walker, Nicole A., Crawford, Darrell H.G., Subramaniam, V. Nathan and Wallace, Daniel F. (2008). Juvenile iron overload: Advances, but no answers. Journal of Pediatrics, 153 (4), 588-588. doi: 10.1016/j.jpeds.2008.06.005
Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression
Theurl, Milan, Theurl, Igor, Hochegger, Kathrin, Obrist, Peter, Subramaniam, Nathan, van Rooijen, Nico, Schuemann, Klaus and Weiss, Guenter (2008). Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression. Journal of Molecular Medicine, 86 (7), 825-835. doi: 10.1007/s00109-008-0346-y
Wallace, Daniel F., Summerville, Lesa, Crampton, Emily M. and Subramaniam, V. Nathan (2008). Defective trafficking and localization of mutated transferrin receptor 2: Implications for type 3 hereditary hemochromatosis. American Journal of Physiology - Cell Physiology, 294 (2), C383-C390. doi: 10.1152/ajpcell.00492.2007
Wallace, Daniel F. and Subramaniam, V. Nathan (2007). Non-HFE haemochromatosis. World Journal of Gastroenterology, 13 (35), 4690-4698. doi: 10.3748/wjg.v13.i35.4690
A novel mutation in ferroportin implicated in iron overload
Wallace, Daniel F., Dixon, Jeannette L., Ramm, Grant A., Anderson, Gregory J., Powell, Lawrie W. and Subramaniam, V. Nathan (2007). A novel mutation in ferroportin implicated in iron overload. Journal of Hepatology, 46 (5), 921-926. doi: 10.1016/j.jhep.2007.01.033
Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload
Wallace, Daniel F., Summerville, Lesa and Subramaniam, V. Nathan (2007). Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload. Gastroenterology, 132 (1), 301-310. doi: 10.1053/j.gastro.2006.11.028
Walsh, Alissa, Dixon, Jeannette L., Ramm, Grant A., Hewett, David G., Lincoln, Douglas J., Anderson, Gregory J., Subramaniam, V. Nathan, Dodemaide, Julian, Cavanaugh, Juleen A., Bassett, Mark L. and Powell, Lawrie W. (2006). The clinical relevance of compound heterozygosity for the C282Y and H63D substitutions in hemochromatosis. Clinical Gastroenterology and Hepatology, 4 (11), 1403-1410. doi: 10.1016/j.cgh.2006.07.009
Clinical expression of C282Y hornozygous HFE haernochromatosis at 14 years of age
Rossi, Enrico, Wallace, Daniel F., Subramaniam, V. Nathan, St Pierre, Timothy G., Mews, Catherine and Jeffrey, Gary P. (2006). Clinical expression of C282Y hornozygous HFE haernochromatosis at 14 years of age. Annals of Clinical Biochemistry, 43 (3), 233-236. doi: 10.1258/000456306776865197
Purification and partial characterisation of recombinant human hepcidin
Wallace, Daniel F., Jones, Marc D., Pedersen, Palle, Rivas, Lucy, Sly, Lindsay I. and Subramaniam, V. Nathan (2006). Purification and partial characterisation of recombinant human hepcidin. Biochimie, 88 (1), 31-37. doi: 10.1016/j.biochi.2005.07.003
Screening for hemochromatosis in asymptomatic subjects with or without a family history
Powell, Lawrie W., Dixon, Jeannette L., Ramm, Grant A., Purdie, David M., Lincoln, Douglas J., Anderson, Gregory J., Subramaniam, V. Nathan, Hewett, David G., Searle, Jeffrey W., Fletcher, Linda M., Crawford, Darrell H., Rodgers, Helen, Allen, Katrina J., Cavanaugh, Juleen A. and Bassett, Mark L. (2006). Screening for hemochromatosis in asymptomatic subjects with or without a family history. Archives of Internal Medicine, 166 (3), 294-301. doi: 10.1001/archinte.166.3.294
Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes
Wallace, Daniel F., Summerville, Lesa, Lusby, Patricia E. and Subramaniam, V. Nathan (2005). Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes. Journal of Hepatology, 43 (4), 720-728. doi: 10.1016/j.jhep.2005.02.047
First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin
Wallace, D. F., Summerville, L., Lusby, P. E. and Subramaniam, V. N. (2005). First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin. Gut, 54 (7), 980-986. doi: 10.1136/gut.2004.062018
Identification of ferroportin disease in the Indian subcontinent
Wallace, D. F., Browett, P., Wong, P., Kua, H., Ameratunga, R. and Subramaniam, V. N. (2005). Identification of ferroportin disease in the Indian subcontinent. Gut, 54 (4), 567-568. doi: 10.1136/gut.2004.060988
Loh, Eva, Peter, Frank, Subramaniam, V. Nathan and Hong, Wanjin (2005). Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus. Journal of Cell Science, 118 (6), 1209-1222. doi: 10.1242/jcs.01723
Wallace, Daniel F., Dixon, Jeannette L., Ramm, Grant A., Anderson, Gregory J., Powell, Lawrie W. and Subramaniam, Nathan (2005). Hemojuvelin (HJV)-associated hemochromatosis: Analysis of HJV and HFE mutations and iron overload in three families. Haematologica, 90 (2), 254-255.
Ferroportin disease due to the A77D mutation in Australia
Subramaniam, V. N., Wallace, D. F., Dixon, J. L., Fletcher, L. M. and Crawford, D. H. (2005). Ferroportin disease due to the A77D mutation in Australia. Gut, 54 (7), 1048-1049. doi: 10.1136/gut.2005.069021
Genetic disorders in gastroenterology and hepatology - HFE gene and hemochromatosis
Ramm, G. A., Subramaniam, V. N. and Powell, L. W. (2004). Genetic disorders in gastroenterology and hepatology - HFE gene and hemochromatosis. Journal of Gastroenterology and Hepatology, 19 (6), 712-712. doi: 10.1111/j.0815-9319.2004.03499.x
Inactivation of the murine Transferrin receptor 2 gene using the Cre recombinase: IoxP system
Wallace, Daniel F., Tonks, Ian D., Zournazi, Anna, Kay, Graham F. and Subramaniam, V. Nathan (2004). Inactivation of the murine Transferrin receptor 2 gene using the Cre recombinase: IoxP system. Genesis, 39 (1), 38-41. doi: 10.1002/gene.20023
Wallace, Daniel F., Clark, Roslyn M., Harley, Hugh A. J. and Subramaniam, V. Nathan (2004). Autosomal dominant iron overload due to a novel mutation of ferroportin1 associated with parenchymal iron loading and cirrhosis. Journal of Hepatology, 40 (4), 710-713. doi: 10.1016/j.jhep.2003.12.008
Anderson, Gregory J., Frazer, David M., Bridle, Kim R., Crawford, Darell H. G., Subramaniam, V. Nathan, Powell, Lawrie W. and Ramm, Grant A. (2004). Reply. Gastroenterology, 126 (2), 616-616. doi: 10.1053/j.gastro.2003.12.054
Ironing out doxorubicin-related cardiotoxicity
Subramaniam, V. N. (2003). Ironing out doxorubicin-related cardiotoxicity. Blood, 102 (7), 2317-2318. doi: 10.1182/blood-2003-07-2517
A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient
ArdenKE, WallaceDF, DixonJL, SummervilleL, SearleJW, AndersonGJ, RammGA, PowellLW and Subramaniam, V. N. (2003). A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient. Gut, 52 (8), 1215-1217. doi: 10.1136/gut.52.8.1215
Bridle, K. R., Frazer, D. M., Wilkins, S. J., Dixon, J. L., Purdie, D. M., Crawford, D. H. G., Subramaniam, V. N, Powell, L. W., Anderson, G. J. and Ramm, G. A. (2003). Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet, 361 (9358), 669-673. doi: 10.1016/S0140-6736(03)12602-5
Novel mutation in ferroponin1 is associated with autosomal dominant hemochromatosis
Wallace, Daniel F., Pedersen, Palle, Dixon, Jeannette L., Stephenson, Peter, Searle, Jeffrey W., Powell, Lawrie W. and Subramaniam, V. Nathan (2002). Novel mutation in ferroponin1 is associated with autosomal dominant hemochromatosis. Blood, 100 (2), 692-694. doi: 10.1182/blood.V100.2.692
Frequency of the S65C mutation of HFE and iron overload in 309 subjects heterozygous for C282Y
Wallace, Daniel F., Walker, Ann P., Pietrangelo, Antonello, Clare, Michael, Bomford, Adrian B., Dixon, Jeannette L., Powell, Lawrie W., Subramaniam, V. Nathan and Dooley, James S. (2002). Frequency of the S65C mutation of HFE and iron overload in 309 subjects heterozygous for C282Y. Journal of Hepatology, 36 (4), 474-479. doi: 10.1016/S0168-8278(01)00304-X
Monteiro, M. J., Subramaniam, N., Taylor, J. R., Pham, B. T. T., Tonge, M. P. and Gilbert, R. G. (2001). Retardative chain transfer in free radical free-radical polymerisations of vinyl neo-decanoate in low molecular weight polyisoprene and toluene. Polymer, 42 (6), 2403-2411. doi: 10.1016/S0032-3861(00)00647-9
Role of p97 and syntaxin 5 in the assembly of transitional endoplasmic reticulum
Roy, Line, Bergeron, John J. M., Lavoie, Christine, Hendriks, Rob, Gushue, Jennifer, Fazel, Ali, Pelletier, Amelie, Morre, D. James, Subramaniam, V. Nathan, Hong, Wanjin and Paiement, Jacques (2000). Role of p97 and syntaxin 5 in the assembly of transitional endoplasmic reticulum. Molecular Biology of The Cell, 11 (8), 2529-2542. doi: 10.1091/mbc.11.8.2529
Preferential association of syntaxin 8 with the early endosome
Subramaniam, V. N., Loh, E., Horstmann, H., Habermann, A., Xu, Y., Coe, J., Griffiths, G. and Hong, W. J. (2000). Preferential association of syntaxin 8 with the early endosome. Journal of Cell Science, 113 (6), 997-1008.
Haemochromatosis in the new millennium
Powell, Lawrie W., Subramaniam, V. Nathan and Yapp, Thomas R. (2000). Haemochromatosis in the new millennium. Journal of Hepatology, 32 (Supplement 1), 48-62. doi: 10.1016/S0168-8278(00)80415-8
CDNA characterization and chromosomal mapping of human Golgi SNARE GS27 and GS28 to chromosome 17
Bui, T. D., Levy, E. R., Subramaniam, V. N., Lowe, S. L. and Hong, W. J. (1999). CDNA characterization and chromosomal mapping of human Golgi SNARE GS27 and GS28 to chromosome 17. Genomics, 57 (2), 285-288. doi: 10.1006/geno.1998.5649
GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with syntaxin 6
Wong, Siew Heng, Xu, Yue, Zhang, Tao, Griffiths, Gareth, Lowe, Stephen Loucian, Subramaniam, V. Nathan, Seow, Kah Tong and Hong, Wanjin (1999). GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with syntaxin 6. Molecular Biology of The Cell, 10 (1), 119-134. doi: 10.1091/mbc.10.1.119
Zeng, Qi, Subramaniam, V. Nathan, Wong, Siew Heng, Tang, Bor Luen, Parton, Robert G., Rea, Shane, James, David E. and Hong, Wanjin (1998). A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane. Molecular Biology of The Cell, 9 (9), 2423-2437. doi: 10.1091/mbc.9.9.2423
Peter, F., Wong, S. H., Subramaniam, V. N., Tang, B. L. and Hong, W. J. (1998). alpha-SNAP but not gamma-SNAP is required for ER-Golgi transport after vesicle budding and the Rab1-requiring step but before the EGTA-sensitive step. Journal of Cell Science, 111 (17), 2625-2633.
Xu, Y., Wong, S. H., Tang, B. L., Subramaniam, V. N., Zhang, T. and Hong, W. J. (1998). A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (Vti1-rp2) implicated in protein trafficking in the secretory pathway. Journal of Biological Chemistry, 273 (34), 21783-21789. doi: 10.1074/jbc.273.34.21783
Wong, Siew Heng, Zhang, Tao, Xu, Yue, Subramaniam, V. Nathan, Griffiths, Gareth and Hong, Wanjin (1998). Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome. Molecular Biology of The Cell, 9 (6), 1549-1563. doi: 10.1091/mbc.9.6.1549
Zhang, T., Wong, S. H., Tang, B. L., Xu, Y., Peter, F., Subramaniam, V. N. and Hong, W. J. (1997). The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus. Journal of Cell Biology, 139 (5), 1157-1168. doi: 10.1083/jcb.139.5.1157
A SNARE involved in protein transport through the Golgi apparatus
Lowe, S. L., Peter, F., Subramaniam, V. N., Wong, S. H. and Hong, W. J. (1997). A SNARE involved in protein transport through the Golgi apparatus. Nature, 389 (6653), 881-884. doi: 10.1038/39923
Subramaniam, V. N., Loh, E. and Hong, W. J. (1997). N-ethylmaleimide-sensitive factor (NSF) and α-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex. Journal of Biological Chemistry, 272 (41), 25441-25444. doi: 10.1074/jbc.272.41.25441
Xu, Y., Wong, S. H., Zhang, T., Subramaniam, V. N. and Hong, W. J. (1997). GS15, a 15-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) homologous to rbet1. Journal of Biological Chemistry, 272 (32), 20162-20166. doi: 10.1074/jbc.272.32.20162
GS28, a 28-kilodalton golgi SNARE that participates in ER-Golgi transport
Subramaniam, V. N., Peter, F., Philp, R., Wong, S. H. and Hong, W. J. (1996). GS28, a 28-kilodalton golgi SNARE that participates in ER-Golgi transport. Science, 272 (5265), 1161-1163. doi: 10.1126/science.272.5265.1161
Monoclonal-Antibody Hfd9 Identifies a Novel 28 Kda Integral Membrane-Protein On the Cis-Golgi
Subramaniam, VN, Krijnselocker, J, Tang, BL, Ericsson, M, Yusoff, Arb, Griffiths, G and Hong, WJ (1995). Monoclonal-Antibody Hfd9 Identifies a Novel 28 Kda Integral Membrane-Protein On the Cis-Golgi. Journal of Cell Science, 108, 2405-2414.
Miao, YJ, Subramaniam, N and Carlson, DM (1995). Cdna Cloning and Characterization of Rat Salivary Glycoproteins - Novel Members of the Proline-Rich-Protein Multigene Families. European Journal of Biochemistry, 228 (2), 343-350.
Cytosolic Factors Block Antibody-Binding to the C-Terminal Cytoplasmic Tail of the Kdel Receptor
Tang, BL, Wong, SH, Low, SH, Subramaniam, VN and Hong, WJ (1994). Cytosolic Factors Block Antibody-Binding to the C-Terminal Cytoplasmic Tail of the Kdel Receptor. European Journal of Cell Biology, 65 (2), 298-304.
Tang, BL, Wong, SH, Qi, XL, Subramaniam, VN and Hong, WJ (1992). Golgi-Localized Beta-Galactoside Alpha-2,6-Sialyltransferase in Transfected Cho Cells Is Redistributed Into the Endoplasmic-Reticulum by Brefeldin-a. European Journal of Cell Biology, 59 (1), 228-231.
Biochemical fractionation and characterization of proteins from Golgi-enriched membranes
Subramaniam, V. N., Bin Mohd Yusoff, A. R., Wong, S. H., Lim, G. B., Chew, M. and Hong, W. J. (1992). Biochemical fractionation and characterization of proteins from Golgi-enriched membranes. Journal of Biological Chemistry, 267 (17), 12016-12021.
Low, Seng Hui, Wong, Siew Heng, Tang, Bor Luen, Tan, Patrick, Subramaniam, V. Nathan and Hong, Wanjin (1991). Inhibition by brefeldin A of protein secretion from the apical cell surface of Madin-Darby canine kidney cells. Journal of Biological Chemistry, 266 (27), 17729-17732.
Low, Seng Hui, Wong, Siew Heng, Tang, Bor Luen, Subramaniam, V. Nathan and Hong, Wanjin (1991). Apical cell surface expression of rat dipeptidyl peptidase IV in transfected Madin-Darby canine kidney cells. Journal of Biological Chemistry, 266 (20), 13391-13396.
Barton, James, Chen, Wen-Pin, Emond, Mary, Phatak, Pradyumna, Subramaniam, V. Nathan, Adams, Paul, Gurrin, Lyle, Anderson, Gregory, Ramm, Grant, Powell, Lawrie, Allen, Katrina, Phillips, John, Parker, Charles, McLaren, Gordon and McLaren, Christine (2017). INDEPENDENT ASSOCIATION OF GNPAT p.D519G WITH MARKEDLY INCREASED IRON STORES IN HFE p.C282Y HOMOZYGOTES. HOBOKEN: WILEY.
Barton, James, McLaren, Christine, Chen, Wen-Pin, Ramm, Grant, Anderson, Gregory, Powell, Lawrie, Subramaniam, V. Nathan, Adams, Paul, Phatak, Pradyumna, Gurrin, Lyle, Phillips, John D., Parker, Charles J., Edmond, Mary J. and McLaren, Gordon (2017). INDEPENDENT RISK FACTORS FOR BIOPSY-PROVEN CIRRHOSIS IN HEMOCHROMATOSIS: A STUDY OF 110 HFE p.C282Y HOMOZYGOTES WITH GNPAT p.D519G GENOPTYING. HOBOKEN: WILEY.
Wallace, D. F., Mcdonald, C. J., Ostini, L., Iser, D., Tuckfield, A. and Subramaniam, V. N. (2017). A novel assay for studying the hepcidin-ferroportin axis and its application in characterizing a new SLC40A1 mutation. WILEY.
Barton, J. C., Chen, W., Emond, M. J., Phatak, P. D., Subramaniam, V. N., Adams, P. C., Gurrin, L. C., Anderson, G. J., Ramm, G. A., Powell, L. W., Allen, K. J., Phillips, J. D., Parker, C. J. and McLaren, C. E. (2017). GNPAT P.D519G IS INDEPENDENTLY ASSOCIATED WITH MARKEDLY INCREASED IRON STORES IN HFE P.C282Y HOMOZYGOTES. Western Medical Research Conference, Carmel Ca, Jan 26-28, 2017. LONDON: BMJ PUBLISHING GROUP. doi: 10.1136/jim-2016-000365.435
Iron blocks the secretion of apolipoprotein E in cultured human adipocytes
Britton, L. J., Bridle, K., Jaskowski, L. A., He, J., Ng, C., Ruelcke, J. E., Reiling, J., Santrampurwala, N., Hill, M. M., Whitehead, J. P., Subramaniam, V. N. and Crawford, D. H. G. (2017). Iron blocks the secretion of apolipoprotein E in cultured human adipocytes. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology , Gold Coast, QLD, Australia, 20–22 August 2017. Hoboken, NJ United States: Wiley-Blackwell Publishing.
Wallace, Daniel, Sandhu, Kam, Flintoff, Kaledas, Dixon, Jeannette, Ramm, Louise, Ramm, Grant, Powell, Lawrie and Subramaniam, V. Nathan (2017). Non-Hfe Haemochromatosis: a Phenotypic and Clinical Analysis of Published Cases and Comparison with Hfe-Haemochromatosis. WILEY.
McLaren, G. D., Powell, L. W., Phatak, P. D., Barton, J. C., Adams, P. C., Subramaniam, V. N., Gurrin, L. C., Phillips, J. D., Parker, C., Allen, K. J., Chen, W-P, Emond, M. J., Nickerson, D. A., Ramm, G. A., Anderson, G. J. and McLaren, C. E. (2016). Differences in Clinical Manifestations of Hemochromatosis in Hfe C282Y Homozygotes with Extreme High and Low Iron Phenotypes. HOBOKEN: W B SAUNDERS CO.
Development of peptide therapeutics for iron disorders
Goncalves, Daniela, Rishi, Gautam, Aliyanto, Randy, Rosengren, Johan, Subramaniam, Nathan, Frazer, David and Clark, Richard (2016). Development of peptide therapeutics for iron disorders. 6th Meeting of the International BioIron Society, Zhejiang University, Hangzhou, China, 8-10 September 2015. Hoboken, NJ, United States: John Wiley & Sons.
Emond, Mary, McLaren, Christine, Louie, Tin, Wu, Jie, Powell, Lawrie, Phatak, Pradyumna, Barton, James, Adams, Paul, Gurrin, Lyle, Phillips, John, Parker, Charles, Allen, Katrina, Nickerson, Deborah, Anderson, Gregory, Subramaniam, Nathan, McLaren, Gordon and Ramm, Grant (2016). Exome Sequencing in Hfe C282Y Homozygotes with Extreme Hepatic Iron Overload Reveals Modifying Genes for the Development of Cirrhosis. WILEY-BLACKWELL.
Iron and Erythropoiesis: a Novel Role for Transferrin Receptor 2 in Stress Erythropoiesis
Rishi, Gautam, Wallace, Daniel, Secondes, Eriza and Subramaniam, Nathan (2016). Iron and Erythropoiesis: a Novel Role for Transferrin Receptor 2 in Stress Erythropoiesis. WILEY-BLACKWELL.
Wallace, Daniel and Subramaniam, V. Nathan (2016). Non-Hfe Haemochromatosis: Estimation of the Global Prevalence From Analysis of Next-Generation Sequencing Data. WILEY-BLACKWELL.
Free fatty acid treatment reduces BMP6 signalling in AML12 hepatocytes
Santrampurwala, N., Bridle, K. R., Reiling, J., Britton, L. J., Jaskowski, L. A., Subramaniam, V. N. and Crawford, D. H. G. (2015). Free fatty acid treatment reduces BMP6 signalling in AML12 hepatocytes. Gastro 2015 GESA-AGW and WGO International Congress, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13087
Mcdonald, C. J., Ostini, L., Wallace, D. F., Lyons, A., Crawford, D. H. G. and Subramaniam, V. N. (2015). Next-generation sequencing: application of a novel platform to the analysis of atypical iron disorders. Gastro 2015 GESA‐AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, QLD, Australia, 28 September - 2 October 2015. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia.
Serum adipokines in response to venesection in patients with non-alcoholic fatty liver disease
Britton, L., Bridle, K., Reiling, J., Santrampurwala, N., Wockner, L., Ching, H., Subramaniam, V., Crawford, D. and Adams, L. (2015). Serum adipokines in response to venesection in patients with non-alcoholic fatty liver disease. Gastro 2015 GESA-AGW and WGO International Congress, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13087
Wallace, D. F. and Subramaniam, V. N. (2015). The global prevalence of non-HFE haemochromatosis estimated from analysis of next-generation sequencing data. Gastro 2015 GESA-AGW and WGO International Congress, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13087
McLaren, Gordon D., Emond, Mary J., Subramaniam, V. Nathan, Phatak, Pradyumna D., Barton, James C., Adams, Paul C., Goh, Justin B., McDonald, Cameron J., Powell, Lawrie W., Gurrin, Lyle C., Allen, Katrina J., Nickerson, Deborah A., Louie, Tin, Ramm, Grant A., Anderson, Gregory J. and McLaren, Christine E. (2014). Exome Sequencing Identifies a GNPAT Variant Associated with Severe Iron Overload in HFE C282Y Homozygous Men with Extreme Phenotypes; Possible Role in Regulation of Hepcidin Expression. 56th Annual Meeting of the American-Society-of-Hematology, San Francisco, CA, United States, 6-9 December 2014. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V124.21.745.745
Hepatic microRNA expression is altered in a murine model of iron and fat co-mediated liver injury
Mcdonald, C. J., Yuan, Y., Santrampurwala, N., Crawford, D. H. G. and Subramaniam, V. N. (2014). Hepatic microRNA expression is altered in a murine model of iron and fat co-mediated liver injury. HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/jgh.12736_5
Fernandez-Rojo, M., Burgess, A., Glanfield, A., Hoang-Le, D., Subramaniam, N. and Ramm, G. (2014). The role of receptor-mediated endocytosis of H-ferritin-induced proinflammatory signaling in hepatic stellate cells. HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/jgh.12736_7
Wallace, D. F., Secondes, E. S., Rishi, G., Ostini, L., Mcdonald, C. J., Lane, S. W., Hooper, J. D., Lopez-Otin, C. and Subramaniam, V. N. (2014). Investigation of mice deficient in matriptase-2, Hfe and transferrin receptor 2 reveals a novel non-hepatic role for Tfr2 in erythropoiesis. Australian Gastroenterology Week 2014, Broadbeach, Australia, 22-24 October 2014. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736_6
An Essential Role For Transferrin Receptor 2 In Erythropoiesis During Iron Restriction
Wallace, Daniel F., McDonald, Cameron J., Secondes, Eriza S., Ostini, Lesa, Rishi, Gautam, Hooper, John D., Velasco, Gloria, Ramsay, Andrew J., Lopez-Otin, Carlos and Subramaniam, V. Nathan (2013). An Essential Role For Transferrin Receptor 2 In Erythropoiesis During Iron Restriction. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans La, Dec 07-10, 2013. WASHINGTON: AMER SOC HEMATOLOGY.
McLaren, Christine E., Emond, Mary J., Phatak, Pradyumna D., Adams, Paul C., Subramaniam, V. Nathan, Barton, James C., Powell, Lawrie W., Gurrin, Lyle C., Allen, Katrina J., Nickerson, Deborah A., Louie, Tin, Ramm, Grant A., Anderson, Gregory J. and McLaren, Gordon D. (2013). Exome Sequencing Identifies Genes and Variant Alleles Associated With Severity Of Iron Overload In Hemochromatosis HFE C282Y Homozygotes. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans La, Dec 07-10, 2013. WASHINGTON: AMER SOC HEMATOLOGY.
McDonald, Cameron, Wallace, Daniel, Ostini, Lesa and Subramaniam, Nathan (2013). Differential Response of the Hepcidin Regulatory Pathway to Oral Versus Perenteral Iron in Mice Lacking Hfe and Tfr2. HOBOKEN: WILEY-BLACKWELL.
McLaren, Christine E., Phatak, Pradyumna D., Adams, Paul C., Subramaniam, V. Nathan, Barton, James C., Garner, Chad P., Powell, Lawrie W., Gurrin, Lyle C., Allen, Katrina J., Nickerson, Deborah A., Ramm, Grant A., Anderson, Gregory J. and McLaren, Gordon D. (2013). IDENTIFICATION OF GENES AND VARIANT ALLELES ASSOCIATED WITH IRON OVERLOAD IN HEMOCHROMATOSIS HFE C282Y HOMOZYGOTES. HOBOKEN: WILEY-BLACKWELL.
Rishi, Gautam, Wallace, Daniel and Subramaniam, V. Nathan (2013). PROXIMITY LIGATION ASSAYS INDICATE THAT HEMOCHROMATOSIS PROTEINS HFE AND TRANSFERRIN RECEPTOR 2 (TFR2) DO NOT INTERACT. HOBOKEN: WILEY-BLACKWELL.
Wilkinson, Ashley S., Bridle, Kim, Britton, Laurence, Jaskowski, Lesley, Fletcher, Linda M., Subramaniam, V. Nathan and Crawford, Darrell H. (2013). Administration of an iron-deficient diet attenuates diet-induced hepatic steatosis in HFE-associated non-alcoholic fatty liver disease using Hfe-/- mice. 64th Annual Meeting and Postgraduate Course of the American Association for the Study of Liver Diseases, Washington, DC, United States, 1 - 5 November 2013. Hoboken, NJ, United States: John Wiley & Sons.
Wilkinson, A. S., Bridle, K. R., Britton, L. J., Jaskowski, L. A., Fletcher, L. M., Subramaniam, V. N. and Crawford, D. H. G. (2013). An iron-deficient diet attenuates diet-induced hepatic steatosis in HFE-associated non-alcoholic fatty liver disease using Hfe(-/-) mice. The Australian Gastroenterology Week 2013, Melbourne, VIC Australia, 7 - 9 October 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365
Bennett, Nigel C., McDonald, Cameron J., Wallace, Daniel F., Hooper, John D., Lopez-Otin, Carlos and Subramaniam, V. Nathan (2013). Clinically Identified Tmprss6 Mutations Result in Either Trafficking Defects or Inability to Cleave Hemojuvelin. BioIron 2013: 5th Meeting of the International BioIron Society, University College London UK, April 14 – 18, 2013. Hoboken, United States: Jossey Bass, Ed. & Pub.. doi: 10.1002/ajh.23453
Britton, Laurence, Jaskowski, Lesley, Wilkinson, Ashley, Bridle, Kim, Subramaniam, Nathan and Crawford, Darrell (2013). Heterozygous Deletion of the Hfe Gene Contributes to Hepatic Iron Loading But Not Steatosis in Mice Fed a High Fat Diet. 5th Meeting of the International BioIron Society, University College London UK, 14 - 18 May 2013. Hoboken, NJ United States: John Wiley and Sons, Inc. doi: 10.1002/ajh.23453
Britton, L., Jaskowski, L., Wilkinson, A., Bridle, K., Subramaniam, N. and Crawford, D. (2013). Heterozygous Hfe (haemochromatosis) gene deletion contributes to hepatic iron loading but not steatosis in mice fed a high fat diet. The Australian Gastroenterology Week 2013, Melbourne, VIC Australia, 7 - 9 October 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365
Santrampurwala, N., Bridle, K. R., Heritage, M. L., Jaskowski, L. A., Wilkinson, A. S., Subramaniam, V. N. and Crawford, D. H. G. (2013). Hfe-associated steatohepatitis: Expression profiling and identifying the molecular basis of liver injury. The Australian Gastroenterology Week 2013, Melbourne, VIC Australia, 7 - 9 October 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365
Sobbe, A. L., Frazer, D. M., Bridle, K. R., Jaskowski, L. A., Anderson, G. J., Subramaniam, V. N. and Crawford, D. H. (2013). Impaired iron uptake in Mdr2(-/-) mice results in hepatic iron deficiency: implications for patients with cholestatic liver injury. The Australian Gastroenterology Week 2013, Melbourne, VIC Australia, 7 - 9 October 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365
Sobbe, Amy, Frazer, David, Bridle, Kim, Jaskowski, Lesley, Ostini, Lesa, de Guzman, Erika, Santrampurwala, Nishreen, Anderson, Gregory, Subramaniam, V. Nathan and Crawford, Darrell (2013). Isolated Hepatic Iron Deficiency Despite Abundant Systemic Iron in Mdr2-/- Mice: Integrity of the Biliary Transport System Is Important in Liver Iron Homeostasis. 5th Meeting of the International BioIron Society, University College London UK, 14 - 18 May 2013. Hoboken, NJ United States: John Wiley and Sons, Inc. doi: 10.1002/ajh.23453
New genetic complexity underlying atypical iron disorders
McDonald, C. J., Wallace, D. F., Crawford, D. H. and Subramaniam, V. N. (2013). New genetic complexity underlying atypical iron disorders. Australian Gastroenterology Week 2013, Melbourne, Australia, 7-9 October 2013. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365
Wallace, Daniel, Mcdonald, Cameron, Ostini, Lesa and Subramaniam, Nathan (2012). A central role for HFE and transferrin receptor 2 in the non-parenchymal cell-derived BMP6-mediated regulation of hepcidin. The Australian Gastroenterology Week 2012, Adelaide SA, Australia, 16-19 October 2012. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2011.07251.x
Application of next-generation sequencing technology to diagnosis of genetic iron disorders
McDonald, Cameron, Wallace, Daniel, Crawford, Darrell H. and Subramaniam, Nathan (2012). Application of next-generation sequencing technology to diagnosis of genetic iron disorders. Australian Gastroenterology Week 2012, Adelaide, SA, Australia, 16-19 October 2012. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/j.1440-1746.2011.07251.x
Wilkinson, Ashley S., Heritage, Mandy L., Jaskowski, Lesley A., Britton, Laurence J., Tan, Terrence C., Clouston, Andrew, Bridle, Kim, Macdonald, Graeme A., Anderson, Gregory, Fletcher, Linda M., Subramaniam, Nathan and Crawford, Darrell H. (2012). Curcumin and vitamin E combination treatment reduces the severity of disease in a diet-induced mouse model of NAFLD. Australian Gastroenterology Week 2012, Adelaide, SA, Australia, 16-19 October 2012. Richmond, Vic., Australia: Wiley-Blackwell Publishing. doi: 10.1111/j.1440-1746.2011.07251.x
Deferasirox does not exhibit antifibrotic activity when administered to Mdr2-/- mice
Sobbe, Amy, Bridle, Kim, de Guzman, Cloe Erika, Santrampurwala, Nishreen, Subramaniam, Nathan and Crawford, Darrell H. (2012). Deferasirox does not exhibit antifibrotic activity when administered to Mdr2-/- mice. Australian Gastroenterology Week 2012, Adelaide, SA, Australia, 16-19 October 2012. Richmond, Vic., Australia: Wiley-Blackwell Publishing. doi: 10.1111/j.1440-1746.2011.07251.x
Tan, Terrence C., Crawford, Darrell H., Jaskowski, Lesley, Santrampurwala, Nishreen, Heritage, Mandy, Subramaniam, V. Nathan, Clouston, Andrew D., Crane, Denis I., Anderson, Gregory J. and Fletcher, Linda M. (2012). Iron Toxicity Impairs Autophagy and Promotes ER Stress in Obesity and Alcohol-Induced Fibrosing Steatohepatitis. 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), Boston, MA, United States, 9-13 November 2012. Hoboken, NJ, United States: John Wiley and Sons. doi: 10.1002/hep.26040
Tan, Terrence C., Crawford, Darrell H., Jaskowski, Lesley A., Murphy, Therese L., Santrampurwala, Nishreen, Heritage, Mandy L., Subramaniam, Nathan, Clouston, Andrew, Crane, Denis I., Anderson, Gregory and Fletcher, Linda M. (2012). Iron toxicity impairs autophagy and promotes ER stress in obesity and alcohol-induced fibrosing steatohepatitis. Australian Gastroenterology Week 2012, Adelaide, SA, Australia, 16-19 October 2012. Richmond, Vic., Australia: Wiley-Blackwell Publishing. doi: 10.1111/j.1440-1746.2011.07251.x
Heritage, Mandy, Jaskowski, Lesley, Wilkinson, Ashley S., Britton, Laurence, Tan, Terrence C., Clouston, Andrew D., Bridle, Kim, Anderson, Gregory J., Macdonald, Graeme A., Fletcher, Linda M., Subramaniam, V. Nathan and Crawford, Darrell H. (2012). The progression of NAFLD to NASH in a mouse model of Hfe(-/-)- associated steatohepatitis is attenuated by co-administration of curcumin and vitamin E. 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), Boston MA., United States, 9-13 November 2012. Hoboken, NJ United States: John Wiley and Sons. doi: 10.1002/hep.26040
Heritage, Mandy L., Wilkinson, Ashley S., Jaskowski, Lesley A., Britton, Laurence J., Tan, Terrence C., Bridle, Kim, Clouston, Andrew, Anderson, Gregory, Fletcher, Linda M., Macdonald, Graeme A., Subramaniam, Nathan and Crawford, Darrell H. (2012). The progression of NAFLD to NASH in a mouse model of Hfe(-/-)-associated steatohepatitis is attenuated by co-administration of curcumin and vitamin E. Abstracts of the Australian Gastroenterology Week 2012, Adelaide, SA, Australia, 16-19 October 2012. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/j.1440-1746.2011.07251.x
Burgess, Anita, Arnold, Steven, Glanfield, Amber, Hoang-Le, Diem M., Subramaniam, Nathan and Ramm, Grant (2012). The role of receptor-mediated endocytosis of H-ferritin in induction of NF kappa B-dependent proinflammatory signalling in hepatic stellate cells. The Australian Gastroenterology Week 2012, Adelaide SA, Australia, 16-19 October 2012. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2011.07251.x
Altered lipid metabolism in HFE-knockout mice promotes severe NAFLD and early fibrosis
Tan, Terrence C. H., Crawford, Darrell H. G., Jaskowski, Lesley A., Murphy, Therese M., Heritage, Mandy L., Subramaniam, V. Nathan, Clouston, Andrew D., Anderson, Gregory J. and Fletcher, Linda M. (2011). Altered lipid metabolism in HFE-knockout mice promotes severe NAFLD and early fibrosis. Australian Gastroenterology Week 2011, Brisbane, Australia, 12-15 September 2011. MALDEN: WILEY-BLACKWELL.
Sobbe, A. L., Bridle, K. R., Jaskowski, L. A., Ostini, L., De Guzman, C. E., Santrampurwala, N., Subramaniam, V. N., Fletcher, L. M. and Crawford, D. H. (2011). Isolated hepatic iron deficiency despite abundant systemic iron in Mdr2(-/-) mice suggests a liver-specific alteration in iron metabolism. Australian Gastroenterology Week 2011, Brisbane, Australia, 12–15 September 2011. Malden MA United States: Wiley-Blackwell Publishing.
Sobbe, A., Bridle, K., Jaskowski, L., Ostini, L., de Guzman, C. E., Santrampurwala, N., Subramaniam, V. N., Fletcher, L. M. and Crawford, D. H. (2011). Isolated hepatic iron deficiency despite abundant systemic iron in Mdr2(-/-) mice: Integrity of the bile transport system is important in normal liver iron homeostasis. 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco, CA, United States, 4-8 November 2011. Malden MA United States: Wiley-Blackwell Publishing.
Heritage, M., Stuart, K. A., Bridle, K., Murphy, T. L., Sobbe, A., Jaskowski, L., Ostini, L., Subramaniam, V. N., Fletcher, L. M. and Crawford, D. H. (2011). The Altered Expression of Iron Metabolism Genes in Models of Liver Injury Suggests Iron Deficiency in Cholestasis and Inappropriate Regulation of Hepcidin in Hepatocellular Cirrhosis. 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco, CA, United States, 4-8 November 2011. Malden MA United States: Wiley-Blackwell Publishing.
Heritage, M. L., Stuart, K. A., Bridle, K. R., Murphy, T. L., Sobbe, A. L., Jaskowski, L. A., Ostini, L., Subramaniam, V. N., Fletcher, L. M. and Crawford, D. H. G. (2011). The altered expression of iron metabolism genes in models of liver injury suggests iron deficiency in cholestasis and inappropriate regulation of hepcidin in hepatocellular cirrhosis. Australian Gastroenterology Week 2011, Brisbane, Australia, 12–15 September 2011. Malden MA United States: Wiley-Blackwell Publishing.
Tan, T., Crawford, D. H., Jaskowski, L., Murphy, T. L., Subramaniam, V. N. and Fletcher, L. M. (2011). The protective effects of corn-oil diet against alcohol and iron-induced hepatotoxicity in a mouse model of hemochromatosis. 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco Ca, Nov 04-08, 2011. MALDEN: WILEY-BLACKWELL. doi: 10.1002/hep.24666
Blunted hepcidin response to inflammation in the absence of Hfe and Tfr2
Wallace, D. F., Mcdonald, C. J., Ostini, L. and Subramaniam, V. N. (2010). Blunted hepcidin response to inflammation in the absence of Hfe and Tfr2. Australian Gastroenterology Week 2010, Gold Coast, QLD, Australia, 20 -23 October 2010. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2010.06450.x
Clinical expression of HFE-associated haemochromatosis in subjects under 40 years of age
Dixon, J. L., Watt, E. E., Ramm, G. A., Subrmaniam, V. N., Powell, L. W. and Anderson, G. J. (2010). Clinical expression of HFE-associated haemochromatosis in subjects under 40 years of age. Australian Gastroenterology Week 2010, Gold Coast , QLD Australia, 20-23 October 2010. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2010.06451.x
Subramaniam, V. N., Mcdonald, C. J., Ostini, L., Bell, S. J., Demediuk, B. and Wallace, D. F. (2010). G80S-linked ferroportin disease: classical ferroportin disease in an Australian family of Asian descent and reclassification of the mutant as iron transport defective. Australian Gastroenterology Week 2010, Broadbeach, QLD, Australia, 20-23 October 2010. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2010.06450.x
Subramaniam, V. N., Mcdonald, C. J., Ostini, L., Bell, S. J., Demediuk, B. and Wallace, D. F. (2010). Hereditary iron overload in the Asia Pacific: first identification of ferroportin disease in a Vietnamese family. Gastroenterology in Asia Pacific - Excellence in the New Decade, Kuala Lumpa, Malaysia, 19-22 September 2010. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2009.06464.x
Subramaniam, V. N., Summerville, L., Crampton, E. M., Frazer, D. M., Anderson, G. J. and Wallace, D. F. (2008). Combined deletion of HFE and transferrin receptor 2 results in a dramatic disruption in hepcidin regulation and severe iron overload. Australian Gastroenterology Week, Brisbane, QLD, Austalia, 22-25 October 2008. Richmond, Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2008.05613.x
Functional consequences of disease causing mutations in the juvenile haemochromatosis gene
Wallace, D. F., Leddy, E., Summerville, L., Crampton, E. M. and Subramaniam, V. N. (2008). Functional consequences of disease causing mutations in the juvenile haemochromatosis gene. Australian Gastroenterology Week, Brisbane, QLD, Austalia, 22-25 October 2008. Richmond, Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2008.05613.x
Crawford, Darrell H., Murphy, Therese L., Ramm, Louise E., Fletcher, Linda M., Clouston, Andrew D., Anderson, Gregory J., Subramaniam, V. Nathan, Powell, Lawrie W. and Ramm, Grant A. (2008). Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis. The Liver Meeting 2008: 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), San Francisco, CA, U.S.A., 31 October-4 November 2008. Hoboken, NJ, U.S.A.: John Wiley & Sons. doi: 10.1002/hep.22641
Crawford, D. H. G., Murphy, T. L., Ramm, L. E., Fletcher, L. M., Clouston, A. D., Anderson, G. J., Subramaniam, V. N., Powell, L. W. and Ramm, G. A. (2008). Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis. AGW 2008: Australian Gastroenterology Week 08, Brisbane, QLD, Australia, 22-25 October 2008. MALDEN: WILEY-BLACKWELL PUBLISHING, INC. doi: 10.1111/j.1440-1746.2008.05613.x
Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression
Theurl, M., Theurl, I., Hochegger, K., Obrist, P., Subramaniam, N., van Rooijen, N., Schuemann, K. and Weiss, G. (2007). Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression. HOBOKEN: WILEY-LISS.
Disease causing mutations of transferrin receptor 2 cause its intracellular retention
Subramaniam, V. N., Summerville, L. and Wallace, D. F. (2007). Disease causing mutations of transferrin receptor 2 cause its intracellular retention. International BioIron Society Meeting, Kyoto, Japan, 1-6 April 2007. Hoboken, NJ, United States: John Wiley & Sons, Inc.. doi: 10.1002/ajh.20964
Ferroportin : Membrane topologyand characterisation of mutations
Wallace, D. F. and Subramaniam, V. N. (2007). Ferroportin : Membrane topologyand characterisation of mutations. International BioIron Society Meeting, Kyoto, Japan, 1-6 April 2007. Hoboken, NJ, United States: John Wiley & Sons, Inc.. doi: 10.1002/ajh.20964
Liver-specific deletion of the transferrin receptor 2 gene in mice leads to iron overload
Subramaniam, V. N., Summerville, L. and Wallace, D. F. (2007). Liver-specific deletion of the transferrin receptor 2 gene in mice leads to iron overload. International BioIron Society Meeting, Kyoto, Japan, 1-6 April 2007. Hoboken, NJ, United States: John Wiley & Sons, Inc.. doi: 10.1002/ajh.20964
Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload
Wallace, D. F., Summerville, L. and Subramaniam, V. N. (2007). Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload. 42th Annual Meeting of the European Association for the Study of the Liver, Barcelona, Spain, 11-15 April 2007. AMSTERDAM: Elsevier. doi: 10.1016/S0168-8278(07)61717-6
Wallace, D. F., Summerville, L. and Subramaniam, V. N. (2006). Liver-specific deletion of the transferrin receptor 2 gene causes iron overload implicating the liver in regulation of iron homeostasis. OXFORD: BLACKWELL PUBLISHING.
Wallace, D. F., Summerville, L. and Subramaniam, V. N. (2006). Liver-specific deletion of the transferrin receptor 2 gene causes iron overload implicating the liver in regulation of iron homeostasis. Australian Gastroenterology Week, Adelaide, SA, Australia, 11-14 October 2006. Richmond, Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2006.04689.x
The clinical relevance of compound heterozygosity for the haemochromatosis mutations (C282Y/H63D)
Walsh, A., Dixon, J. L., Ranun, G. A., Hewett, D. G., Lincoln, D., Anderson, G. L., Subramaniam, N., Dodermaide, J., Bassett, M. and Powell, L. (2006). The clinical relevance of compound heterozygosity for the haemochromatosis mutations (C282Y/H63D). Digestive Disease Week Meeting/107th Annual Meeting of the American Gastroenterlogical Association, Los Angeles, CA, United States, 20-25 May 2006. PHILADELPHIA: W.B. Saunders.
Expression of the iron regulatory peptide hepcidin is reduced in patients with chronic liver disease
Anderson, Greg, Frazer, David M., Bridle, Kim R., Macdonald, Graeme A., Smith, Jeffrey L., Turlin, Bruno, Subramaniam, Nathan, Crawford, Darrell H., Powell, Lawrie W. and Ramm, Grant A. (2005). Expression of the iron regulatory peptide hepcidin is reduced in patients with chronic liver disease. 47th Annual Meeting of the American Society of Hematology, Atlanta, Georgia, USA, 10-13 December, 2005. Washington, D.C., USA: American Society of Hematology.
Powell, LW, Dixon, JL, Anderson, GA, Subramaniam, VN, Lincoln, DJ, Fletcher, LM, Crawford, DH, Searle, JW and Ramm, GA (2005). Hepatic fibrosis but not cirrhosis in hemochromatosis is reversed by iron removal by phlebotomy therapy.. 56th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, San Francisco CA, NOV 11-15, 2005. HOBOKEN: JOHN WILEY & SONS INC.
Powell, L. W., Dixon, J. L., Ramm, G. A., Anderson, G. J., Subramaniam, V. N., Purdie, D. M., Hewett, D. G., Searle, J. W., Fletcher, L. M., Crawford, D. H., Rodgers, H., Khoo, T. L., Cavanaugh, J. A. and Bassett, M. L. (2004). The penetrance of HFE-associated hemochromatosis as assessed by clinical evaluation and liver biopsy in subjects identified by health checks, family screening or population screening. 55th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), Boston MA, 29 October - 2 November 2004. HOBOKEN: JOHN WILEY & SONS INC.
Bridle, K. R., Frazer, D. M., Wilkins, S. J., Dixon, J. L., Millard, K. N., Crawford, D. H. G., Subramaniam, V. N., Powell, L. W., Anderson, G. J. and Ramm , G. A. (2003). Failure of hepcidin upregulation in HFE-associated haemochromatosis implicates the liver in the regulation of body iron homeostasis. Australian Gastroenterology Week, Cairns, Australia, 7-10 October 2003. Carlton South, Vic., Australia: Blackwell Publishing Asia. doi: 10.1046/j.1440-1746.18.s2.5.x
Powell, L. W., Dixon, J. L., Hewett, D. G., Purdie, D. M., Ramm, G. A., Anderson, G. J., Subramaniam, N., Fletcher, L. M., Crawford, D. H., Cavanaugh, J. A. and Bassett, M. L. (2003). Rates of iron accumulation in untreated subjects homozygous for the C282Y hemochromatosis mutation: Relevance to disease penetrance. 54th Annual Meeting of the American Association for the Study of Liver Disease, Boston, MA, United States, 24-28 October 2003. PHILADELPHIA: W B SAUNDERS CO.
The clinical relevance of compound heterozygosity for the hemochromatosis mutations (C282Y/H63D)
Hewett, D. G.., Dixon, J. L., Purdie, D. M., Ramm, G. A., Anderson, G. J., Subramaniam, N., Fletcher, L. M., Crawford, D. H., Cavanaugh, J. A., Bassett, M. L. and Powell, L. W. (2003). The clinical relevance of compound heterozygosity for the hemochromatosis mutations (C282Y/H63D). 54th Annual Meeting of the American Association for the Study of Liver Disease, Boston, M.A. USA, 24-28 October 2003. PHILADELPHIA: W B SAUNDERS CO.
Powell, L, Dixon, JL, Ramm, G, Anderson, G, Subramaniam, N, Fletcher, L, Crawford, D, Cavanaugh, J and Bassett, M (2002). Phenotypic expression of hfe-associated hemochromatosis in C282Y homozygous relatives: Implications for screening.. 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD), Boston Massachusetts, Nov 01-05, 2002. PHILADELPHIA: W B SAUNDERS CO.
Molecular and cellular characterization of transferrin receptor 2
Subramaniam, V. N., Summerville, L. and Wallace, D. F. (2002). Molecular and cellular characterization of transferrin receptor 2. Meeting of the Cell and Molecular Biology of Membrane Transport Systems and Disorders Conference, Coolangatta, Qld, Australia, 2-5 September 2001. TOTOWA: HUMANA PRESS INC. doi: 10.1385/CBB:36:2-3:235
Non-HFE related haemochromatosis in Australia
Wallace, D. F., Dixon, J. L., Stephenson, P., Searle, J. W., Fletcher, L. M., Crawford, D. H., Subramaniam, V. N. and Powell, L. W. (2001). Non-HFE related haemochromatosis in Australia. 52th Annual Meeting of the American Association for the Study of Liver Diseases, Dallas, TX, United States, 9-13 November 2001. Hoboken, NJ, United States: John Wiley & Sons.
Role or p97 and syntaxin 5 in the assembly of transitional endoplasmic reticulum.
Paiement, J, Roy, L, Hendriks, R, Lavoie, C, Gushue, J, Chever, E, Pelletier, A, Morre, DJ, Subramaniam, VN, Hong, WJ and Bergeron, J (1999). Role or p97 and syntaxin 5 in the assembly of transitional endoplasmic reticulum.. BETHESDA: AMER SOC CELL BIOLOGY.
A novel SNARE protein may involved in Golgi trafficking.
Xu, Y, Wong, SH, Tang, BL, Subramaniam, NV, Zhang, T and Hong, WJ (1998). A novel SNARE protein may involved in Golgi trafficking.. BETHESDA: AMER SOC CELL BIOLOGY.
Identification and characterization of mbet3.
Loh, E, Subramaniam, VN and Hong, WJ (1998). Identification and characterization of mbet3.. BETHESDA: AMER SOC CELL BIOLOGY.
YP26, a 26 KDA protein potentially involved in ER-Golgi transport in the yeast S-cerevisiae.
Coe, JGS, Subramaniam, VN and Hong, WJ (1996). YP26, a 26 KDA protein potentially involved in ER-Golgi transport in the yeast S-cerevisiae.. BETHESDA: AMER SOC CELL BIOLOGY.
alpha-SNAP is required for ER-Golgi transport after vesicle budding but before the docking step
Peter, F, Subramaniam, VN and Hong, WJ (1996). alpha-SNAP is required for ER-Golgi transport after vesicle budding but before the docking step. BETHESDA: AMER SOC CELL BIOLOGY.
Identification and characterization of a 28-Kda golgi protein
Subramaniam, V. N. and Hong, W. (1992). Identification and characterization of a 28-Kda golgi protein. unknown, unknown, unknown. Bethesda, MD, United States: American Society for Cell Biology.
Immunotherapeutic Approaches for Hepatocellular Carcinoma
(2014–2019) Gallipoli Medical Research Foundation
(2016) Doctor Philosophy — Principal Advisor
Transferrin receptor 2 in iron metabolism, its role in liver and extra-hepatic tissue
(2015) Doctor Philosophy — Principal Advisor
Molecular, cellular and functional characterisation of novel proteasomal proteins hDDI1 and hDDI2
(2012) Doctor Philosophy — Principal Advisor
(2010) Master Philosophy — Principal Advisor
(2016) Doctor Philosophy — Associate Advisor
Other advisors:
(2014) Doctor Philosophy — Associate Advisor
Other advisors:
Regulation of transthyretin by human placenta
(2012) Doctor Philosophy — Associate Advisor
The Functional Characterisation of Centrobin in Endocytic Trafficking and Microtubule Dynamics
(2008) Doctor Philosophy — Associate Advisor
Other advisors: