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Professor Elizabeth Powell

ATH - Professor

Princess Alexandra Hospital Southside Clinical Unit
Faculty of Medicine
e.powell@uq.edu.au
+61 7 344 38015

Overview

NAME Professor Elizabeth Ellen POWELL

POSITION TITLE Professor, School of Medicine, The University of Queensland; Hepatologist, Princess Alexandra Hospital

Email e.powell@uq.edu.au

EDUCATION/TRAINING

Bachelor of Medicine and Bachelor of Surgery with First Class Honours (M.B.,B.S.Hons1), The University of Queensland

Fellow of the Royal Australasian College of Physicians

Doctor of Philosophy (PhD), The University of Queensland

Fellow of the Royal College of Physicians, London

Fellow, American Association for the Study of Liver Diseases

Elizabeth Powell is a Hepatologist and Senior Staff Specialist in the Department of Gastroenterology and Hepatology, Princess Alexandra Hospital. She is also Professor, School of Medicine, The University of Queensland, Director of the network Centre for Liver Disease Research in The University of Queensland and a Research Fellow with the American Association for the Study of Liver Diseases. She is also a recent past member of the Executive of the Australian Liver Association.

Professor Powell has a very productive research group, bridging basic science and clinical research. Her main research interests include:

(i) developing strategies to improve the assessment of non-alcoholic fatty liver disease by primary care clinicians and non-hepatology specialists.

(ii) examining ways to improve education and medication management for people with decompensated cirrhosis (advanced liver disease)

(iii) examining the role of injury-stratifying biomarkers for non-alcoholic fatty liver disease

Research Impacts

Contributions to the field: Include shaping two new paradigms in hepatology research: the importance of metabolic risk factors in the progression of chronic liver diseases, and more recently proposing altered hepatic regeneration and the ductular reaction as a potential driver of hepatic fibrosis. This innovative research on the association between the hepatic stem cell niche and fibrosis has led to increasing recognition internationally that fibrogenesis and carcinogenesis may be intrinsically associated with activation of this niche. A significant contribution has been to foster a multidisciplinary, collaborative approach to the field, involving hepatopathology together with molecular and clinical hepatology research. More recently she has established new interdisciplinary partnerships to undertake research in areas related to chronic liver disease management.

Collaborations: Nationally, collaborations include those with researchers from QIMR Berghofer Medical Research Institute, Translational Research Institute and Institute for Molecular Bioscience, the University of Queensland; she also collaborates with clinicians from Inala Primary Care and the Princess Alexandra Hospital. Internationally, she contributes to the Drug-induced liver injury network (DILIN) and International Serious Adverse Events Consortium (iSAEC) (based in the UK) and the International Liver Disease Genetics Consortium. More recently she has partnered with Siemens Healthineers to study prevalence and severity of non-alcoholic fatty liver disease in diabetes clinics and primary care.

Community Engagement: Prof Powell is regularly involved in speaking to General Practitioners and community groups and reviews resources for the Ethnic Communities Council of QLD. She has organized and chaired numerous multidisciplinary networking workshops with the purpose of bringing together clinicians/researchers, showcase what is going on in the field, and open opportunities for communication and collaboration.

Professional Involvement and Peer Review: Prof Powell is a past member of the Editorial Board of Hepatology, the Clinical Research Committee of the American Association for the Study of Liver Diseases and a recent past member of the Executive of the Australian Liver Association. She convened the research workshop for the Asian Pacific Association for the Study of the Liver and was consulted by QLD Government to prepare a report on models of care for liver disease. As a member of Executive, Australian Liver Association, she helped write and review documents on treatment, education and technology pertinent to liver disease. Prof Powell has been a panel member for NHMRC (Career Development Fellowship). She has reviewed project grants for the NHMRC, Wellcome Trust (Health Innovation Challenge Fund) and INSERM, and frequently reviews manuscripts for leading international journals.

International Standing: Prof Powell has international recognition in liver disease research and has been an invited speaker at >15 major international meetings. These include invitations as a faculty member of the American Association for the Study of Liver Disease Postgraduate Course, the International Association for the Study of the Liver Postgraduate Course, the Asia-Pacific Association for the Study of the Liver Postgraduate Course and the International Symposium on Viral Hepatitis and Liver Disease Postgraduate Course. She has also presented at the Siemens Scientific Symposium, Berlin and the International Federation of Clinical Chemistry and Laboratory Medicine, Athens on serum biomarkers for risk stratification in non-alcoholic fatty liver disease.

Supervision and Mentoring: Elizabeth has supervised 8 PhD/MD, 3 Honours and 3 Masters students. She has supervised 4 international scholars from the UK and 1 from the USA.

Qualifications

  • PhD, The University of Queensland
  • MBBS, The University of Queensland

Publications

  • Journal Article: A pragmatic approach identifies a high rate of nonalcoholic fatty liver disease with advanced fibrosis in diabetes clinics and at-risk populations in primary care

    Patel, Preya Janubhai, Hossain, Fabrina, Horsfall, Leigh Ula, Banh, Xuan, Hayward, Kelly Lee, Williams, Suzanne, Johnson, Tracey, Bernard, Anne, Brown, Nigel Neil, Lampe, Guy, Buck, Lyndall, Saad, Nivene, Russell, Anthony William, Valery, Patricia Casarolli, Irvine, Katharine Margaret, Clouston, Andrew Donald, Stuart, Katherine Anne, Rosenberg, William and Powell, Elizabeth Ellen (2018). A pragmatic approach identifies a high rate of nonalcoholic fatty liver disease with advanced fibrosis in diabetes clinics and at-risk populations in primary care. Hepatology Communications, 2 (8), 893-905. doi: 10.1002/hep4.1208

  • Journal Article: Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes

    Ramnath, Divya, Irvine, Katharine M., Lukowski, Samuel W., Horsfall, Leigh U., Loh, Zhixuan, Clouston, Andrew D., Patel, Preya J., Fagan, Kevin J., Iyer, Abishek, Lampe, Guy, Stow, Jennifer L., Schroder, Kate, Fairlie, David P., Powell, Joseph E., Powell, Elizabeth E. and Sweet, Matthew J. (2018). Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes. JCI Insight, 3 (14). doi: 10.1172/jci.insight.120274

  • Journal Article: Underappreciation of non-alcoholic fatty liver disease by primary care clinicians: limited awareness of surrogate markers of fibrosis

    Patel, Preya J., Banh, Xuan, Horsfall, Leigh U., Hayward, Kelly L., Hossain, Fabrina, Johnson, Tracey, Stuart, Katherine A., Brown, Nigel N., Saad, Nivene, Clouston, Andrew, Irvine, Katharine M., Russell, Anthony W., Valery, Patricia C., Williams, Suzanne and Powell, Elizabeth E (2018). Underappreciation of non-alcoholic fatty liver disease by primary care clinicians: limited awareness of surrogate markers of fibrosis. Internal Medicine Journal, 48 (2), 144-151. doi: 10.1111/imj.13667

  • Journal Article: Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis

    Maradana, Muralidhara Rao, Yekollu, Suman Kumar, Zeng, Bijun, Ellis, Jonathan, Clouston, Andrew, Miller, Gregory, Talekar, Meghna, Bhuyan, Zaied Ahmed, Mahadevaiah, Sachin, Powell, Elizabeth E., Irvine, Katharine M., Thomas, Ranjeny and O'Sullivan, Brendan John (2018). Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis. Metabolism: Clinical and Experimental, 78, 80-94. doi: 10.1016/j.metabol.2017.09.002

  • Journal Article: Alcohol consumption in diabetic patients with nonalcoholic fatty liver disease

    Patel, Preya J., Smith, David, Connor, Jason P., Horsfall, Leigh U., Hayward, Kelly L., Hossain, Fabrina, Williams, Suzanne, Johnson, Tracey, Stuart, Katherine A., Brown, Nigel N., Saad, Nivene, Clouston, Andrew D., Irvine, Katharine M., Russell, Anthony W., Valery, Patricia C. and Powell, Elizabeth E. (2017). Alcohol consumption in diabetic patients with nonalcoholic fatty liver disease. Canadian Journal of Gastroenterology and Hepatology, 2017 7927685, 7927685-8. doi: 10.1155/2017/7927685

  • Journal Article: Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis

    Hayward, Kelly L., Valery, Patricia C., Martin, Jennifer H., Karmakar, Antara, Patel, Preya J., Horsfall, Leigh U., Tallis, Caroline J., Stuart, Katherine A., Wright, Penny L., Smith, David D., Irvine, Katharine M., Powell, Elizabeth E. and Cottrell, W. Neil (2017). Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis. World Journal of Gastroenterology, 23 (40), 7321-7331. doi: 10.3748/wjg.v23.i40.7321

  • Journal Article: Optimising care of patients with chronic disease: patient-oriented education may improve disease knowledge and self-management

    Hayward, Kelly L., Horsfall, Leigh U., Ruffin, Brittany J., Cottrell, W. Neil, Chachay, Veronique S., Irvine, Katharine M., Martin, Jennifer H., Powell, Elizabeth E. and Valery, Patricia C. (2017). Optimising care of patients with chronic disease: patient-oriented education may improve disease knowledge and self-management. Internal Medicine Journal, 47 (8), 952-955. doi: 10.1111/imj.13505

  • Journal Article: Multimorbidity and polypharmacy in diabetic patients with NAFLD: implications for disease severity and management

    Patel, Preya Janubhai, Hayward, Kelly Lee, Rudra, Rathiga, Horsfall, Leigh Ula, Hossain, Fabrina, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Clouston, Andrew Donald, Stuart, Katherine Anne, Valery, Patricia Casarolli, Irvine, Katharine Margaret, Russell, Anthony William and Powell, Elizabeth Ellen (2017). Multimorbidity and polypharmacy in diabetic patients with NAFLD: implications for disease severity and management. Medicine, 96 (26) e6761, e6761. doi: 10.1097/MD.0000000000006761

  • Journal Article: Identifying areas of need relative to liver disease: geographic clustering within a health service district

    El-Atem, Nathan, Irvine, Katharine M., Valery, Patricia C., Wojcik, Kyle, Horsfall, Leigh, Johnson, Tracey, Janda, Monika, McPhail, Steven M. and Powell, Elizabeth E. (2017). Identifying areas of need relative to liver disease: geographic clustering within a health service district. Australian Health Review, 41 (4), 407-418. doi: 10.1071/AH15225

View all Publications

Grants

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Supervision

View all Supervision

Publications

Featured Publications

  • A pragmatic approach identifies a high rate of nonalcoholic fatty liver disease with advanced fibrosis in diabetes clinics and at-risk populations in primary care

    Patel, Preya Janubhai, Hossain, Fabrina, Horsfall, Leigh Ula, Banh, Xuan, Hayward, Kelly Lee, Williams, Suzanne, Johnson, Tracey, Bernard, Anne, Brown, Nigel Neil, Lampe, Guy, Buck, Lyndall, Saad, Nivene, Russell, Anthony William, Valery, Patricia Casarolli, Irvine, Katharine Margaret, Clouston, Andrew Donald, Stuart, Katherine Anne, Rosenberg, William and Powell, Elizabeth Ellen (2018). A pragmatic approach identifies a high rate of nonalcoholic fatty liver disease with advanced fibrosis in diabetes clinics and at-risk populations in primary care. Hepatology Communications, 2 (8), 893-905. doi: 10.1002/hep4.1208

  • Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes

    Ramnath, Divya, Irvine, Katharine M., Lukowski, Samuel W., Horsfall, Leigh U., Loh, Zhixuan, Clouston, Andrew D., Patel, Preya J., Fagan, Kevin J., Iyer, Abishek, Lampe, Guy, Stow, Jennifer L., Schroder, Kate, Fairlie, David P., Powell, Joseph E., Powell, Elizabeth E. and Sweet, Matthew J. (2018). Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes. JCI Insight, 3 (14). doi: 10.1172/jci.insight.120274

  • Underappreciation of non-alcoholic fatty liver disease by primary care clinicians: limited awareness of surrogate markers of fibrosis

    Patel, Preya J., Banh, Xuan, Horsfall, Leigh U., Hayward, Kelly L., Hossain, Fabrina, Johnson, Tracey, Stuart, Katherine A., Brown, Nigel N., Saad, Nivene, Clouston, Andrew, Irvine, Katharine M., Russell, Anthony W., Valery, Patricia C., Williams, Suzanne and Powell, Elizabeth E (2018). Underappreciation of non-alcoholic fatty liver disease by primary care clinicians: limited awareness of surrogate markers of fibrosis. Internal Medicine Journal, 48 (2), 144-151. doi: 10.1111/imj.13667

  • Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis

    Maradana, Muralidhara Rao, Yekollu, Suman Kumar, Zeng, Bijun, Ellis, Jonathan, Clouston, Andrew, Miller, Gregory, Talekar, Meghna, Bhuyan, Zaied Ahmed, Mahadevaiah, Sachin, Powell, Elizabeth E., Irvine, Katharine M., Thomas, Ranjeny and O'Sullivan, Brendan John (2018). Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis. Metabolism: Clinical and Experimental, 78, 80-94. doi: 10.1016/j.metabol.2017.09.002

  • Alcohol consumption in diabetic patients with nonalcoholic fatty liver disease

    Patel, Preya J., Smith, David, Connor, Jason P., Horsfall, Leigh U., Hayward, Kelly L., Hossain, Fabrina, Williams, Suzanne, Johnson, Tracey, Stuart, Katherine A., Brown, Nigel N., Saad, Nivene, Clouston, Andrew D., Irvine, Katharine M., Russell, Anthony W., Valery, Patricia C. and Powell, Elizabeth E. (2017). Alcohol consumption in diabetic patients with nonalcoholic fatty liver disease. Canadian Journal of Gastroenterology and Hepatology, 2017 7927685, 7927685-8. doi: 10.1155/2017/7927685

  • Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis

    Hayward, Kelly L., Valery, Patricia C., Martin, Jennifer H., Karmakar, Antara, Patel, Preya J., Horsfall, Leigh U., Tallis, Caroline J., Stuart, Katherine A., Wright, Penny L., Smith, David D., Irvine, Katharine M., Powell, Elizabeth E. and Cottrell, W. Neil (2017). Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis. World Journal of Gastroenterology, 23 (40), 7321-7331. doi: 10.3748/wjg.v23.i40.7321

  • Optimising care of patients with chronic disease: patient-oriented education may improve disease knowledge and self-management

    Hayward, Kelly L., Horsfall, Leigh U., Ruffin, Brittany J., Cottrell, W. Neil, Chachay, Veronique S., Irvine, Katharine M., Martin, Jennifer H., Powell, Elizabeth E. and Valery, Patricia C. (2017). Optimising care of patients with chronic disease: patient-oriented education may improve disease knowledge and self-management. Internal Medicine Journal, 47 (8), 952-955. doi: 10.1111/imj.13505

  • Multimorbidity and polypharmacy in diabetic patients with NAFLD: implications for disease severity and management

    Patel, Preya Janubhai, Hayward, Kelly Lee, Rudra, Rathiga, Horsfall, Leigh Ula, Hossain, Fabrina, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Clouston, Andrew Donald, Stuart, Katherine Anne, Valery, Patricia Casarolli, Irvine, Katharine Margaret, Russell, Anthony William and Powell, Elizabeth Ellen (2017). Multimorbidity and polypharmacy in diabetic patients with NAFLD: implications for disease severity and management. Medicine, 96 (26) e6761, e6761. doi: 10.1097/MD.0000000000006761

  • Identifying areas of need relative to liver disease: geographic clustering within a health service district

    El-Atem, Nathan, Irvine, Katharine M., Valery, Patricia C., Wojcik, Kyle, Horsfall, Leigh, Johnson, Tracey, Janda, Monika, McPhail, Steven M. and Powell, Elizabeth E. (2017). Identifying areas of need relative to liver disease: geographic clustering within a health service district. Australian Health Review, 41 (4), 407-418. doi: 10.1071/AH15225

Book Chapter

  • Does NASH or NAFLD Contribute to Comorbidity of Other Liver Diseases?

    Clouston, Andrew D. and Powell, Elizabeth E. (2007). Does NASH or NAFLD Contribute to Comorbidity of Other Liver Diseases?. Fatty Liver Disease: NASH and Related Disorders. (pp. 276-288) Oxford, UK: wiley. doi: 10.1002/9780470987438.ch23

  • Fatty liver as a cofactor for other liver diseases

    McPherson, S., Clouston, A.D., Jonsson, J.R. and Powell, E. (2007). Fatty liver as a cofactor for other liver diseases. International Hepatology Updates: Nonalcoholic steatohepatitis (NASH). (pp. 161-174) edited by Bataller, R. and Caballeria, J.. Spain: Permanyer Publications.

  • Does NASH or NAFLD contribute to comorbidity of other liver diseases?

    Powell, Elizabeth E. (2005). Does NASH or NAFLD contribute to comorbidity of other liver diseases?. Fatty liver disease: NASH and related disorders. (pp. 276-288) edited by Geoffrey C. Farrell, Jacob George, Pauline de la M. Hall and Arthur J. McCullough. Oxford, United Kingdom: Blackwell.

Journal Article

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Diabetes and non-alcoholic fatty liver disease: implementing the right care, in the right place, at the right time (NAFLD-RRR study)

    Doctor Philosophy — Principal Advisor

    Other advisors:

Completed Supervision

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Links

ResearcherID: B-4455-2011

ORCID: 0000-0001-5008-8061

Scopus ID: 7102407844

Google Scholar ID:

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