Professor David McIntyre

Head, Mater Clinical Unit(Conjoint)

Mater Clinical Unit
Faculty of Medicine

Overview

Professor David McIntyre trained in Endocrinology in Australia and Belgium. He works clinically as Director of Obstetric Medicine at Mater Health Services and is Head of the Mater Clinical Unit for the University of Queensland. David has published over 200 papers (>15000 citations), primarily in the field of medical complications of pregnancy, with a particular focus on diabetes and obesity. Recent research has examined the effects of diabetes, obesity and hypertension during pregnancy on the health of Mothers and Babies, during pregnancy and with long term follow up. David is the Immediate Past Chair of the International Association of Diabetes in Pregnancy Study Groups (IADPSG). In 2016, David became the first Australian trained clinician to receive the Norbert Freinkel Award for contributions to diabetes in pregnancy from the American Diabetes Association. In 2019 he was awarded the Jørgen Pedersen Lecture for diabetes in pregnancy by DPSG Europe and the Stream Lead Award Lecture for “Diabetes and Women” by the International Diabetes Federation.

Research Interests

  • DIabetes in pregnancy
  • Medical complications of pregnancy
  • Obesity in pregnancy
  • Intensive insulin therapy in Type 1 diabetes
  • Life course epidemiology of cardiometabolic disease

Research Impacts

Direct impact on clinical practice:

  • Testing for gestational diabetes mellitus (GDM). Professor McIntyre has been centrally involved in the development and dissemination of the IADPSG recommendations for diagnosis of GDM. This has included membership of the consensus conference, which developed the IADPSG recommendations, and of the writing group, which finalized the proposed criteria. On a national level, he was involved in representations to the college of Obstetrics and Gynecology, ADIPS and the Australian Diabetes Society (ADS) as well as within Queensland) and locally at the Mater Mothers Hospital. He chaired the GDM workgroup for the Statewide Clinical Diabetes Network and was lead author on local GDM guidelines. Internationally, he has been closely involved in similar processes as Chair of IADPSG and a member of the FIGO Pregnancy and Non Communicable Disease (NCD) committee.
  • Intensive diabetes management. Since 2004, he has been a founding member of the OzDAFNE collaboration, which introduced the Dose Adjustment for Normal Eating (DAFNE) system of education in intensive insulin therapy for Type 1 diabetes patients into clinical practice in Australia. This has become the mainstay of such treatment in Queensland and DAFNE courses are now offered in over 20 centres across Australia and New Zealand.

Clinical Practice Guidelines:

Professor McIntyre participated in the development of clinical practice guidelines for Obesity in pregnancy via the Statewide Maternity and Neonatal Network and served as Co-lead of the group which developed a guideline for GDM diagnosis and treatment published in 2015.

Investigator-initiated Clinical Trials:

  • He has been involved in the MiG trial of metformin in the management of gestational diabetes and I have started the first Australian site for the “MiTY” (Metformin in Type 2 diabetes) trial to further examine the use of this medication in pregnancy.
  • He was Chief Investigator B and lead at Mater Health Services for the “SPRING” (Supplementation with Probiotics in Gestation) trial recently reported its negative findings regarding the use of probiotics in GDM prevention.
  • He has initiated two RCTs dealing with lifestyle strategies in the prevention of progression to Type 2 diabetes following GDM.
  • He was CI on a further RCT “TRIM” (Trial of Weight Reduction in New Mums) dealing with optimal dietary follow up to reduce post-partum weight retention in obese pregnant women.

Public Health: Throughhis ole in the National Diabetes in Pregnancy Advisory Committee, he hascontributed to definition of priorities for the care of women with diabetes before, during and after pregnancy. Hiscontributions to GDM care also relate to Public Health as GDM is the commonest identifiable antecedent to overt Type 2 diabetes in parous women.

Qualifications

  • Doctor of Medicine, The University of Queensland
  • FRACP
  • MBBS, The University of Queensland

Publications

  • McIntyre, H. David, Catalano, Patrick, Zhang, Cuilin, Desoye, Gernot, Mathiesen, Elisabeth R. and Damm, Peter (2019). Gestational diabetes mellitus. Nature Reviews Disease Primers, 5 (1) 47. doi: 10.1038/s41572-019-0098-8

  • McIntyre, H. David, Gibbons, Kristen S., Lowe, Julia and Oats, Jeremy J. N. (2018). Development of a risk engine relating maternal glycemia and body mass index to pregnancy outcomes. Diabetes Research and Clinical Practice, 139, 331-338. doi: 10.1016/j.diabres.2018.02.036

  • McIntyre, David, Desoye, Gernot, Dunne, Fidelma, Simeoni, Umberto, H A Visser, Gerard, Kapur, Anil and Hod, Moshe (2018). FIGO analysis of research priorities in hyperglycemia in pregnancy. Diabetes Research and Clinical Practice, 145, 5-14. doi: 10.1016/j.diabres.2018.03.026

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Supervision

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Publications

Featured Publications

  • McIntyre, H. David, Catalano, Patrick, Zhang, Cuilin, Desoye, Gernot, Mathiesen, Elisabeth R. and Damm, Peter (2019). Gestational diabetes mellitus. Nature Reviews Disease Primers, 5 (1) 47. doi: 10.1038/s41572-019-0098-8

  • McIntyre, H. David, Gibbons, Kristen S., Lowe, Julia and Oats, Jeremy J. N. (2018). Development of a risk engine relating maternal glycemia and body mass index to pregnancy outcomes. Diabetes Research and Clinical Practice, 139, 331-338. doi: 10.1016/j.diabres.2018.02.036

  • McIntyre, David, Desoye, Gernot, Dunne, Fidelma, Simeoni, Umberto, H A Visser, Gerard, Kapur, Anil and Hod, Moshe (2018). FIGO analysis of research priorities in hyperglycemia in pregnancy. Diabetes Research and Clinical Practice, 145, 5-14. doi: 10.1016/j.diabres.2018.03.026

Book Chapter

  • Nitert, Marloes Dekker, Callaway, Leonie K., McIntyre, H. David and Barrett, Helen L. (2017). Biomarkers of metabolic and cardiovascular risk in gestational diabetes. Nutrition and diet in maternal diabetes. (pp. 147-159) edited by Rajkumar Rajendram, Victor R. Preedy and Vinood B. Patel. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-319-56440-1_13

  • McIntyre, H. David, Nitert, Marloes Dekker, Barrett, Helen L. and Callaway, Leonie K. (2017). Obesity and diabetes in pregnancy. A practical manual of diabetes in pregnancy. (pp. 87-103) edited by David R. McCance, Michael Maresh and David A. Sacks. Chichester, UK: John Wiley & Sons. doi: 10.1002/9781119043805.ch7

  • Gomez Arango, Luisa F., Barrett, Helen L., Callaway, Leonie K., McIntyre, H. David and Nitert, Marloes Dekker (2017). Probiotics in the prevention of Gestational Diabetes Mellitus (GDM). Nutrition and diet in maternal diabetes. (pp. 275-288) edited by Rajkumar Rajendram, Victor R. Preedy and Vinood B. Patel. Cham: Springer International Publishing. doi: 10.1007/978-3-319-56440-1_22

  • McIntyre, H. David, Baskerville, Catherine and Oats, Jeremy J. N. (2014). Gestational diabetes. Endocrinology and diabetes: a problem-oriented approach. (pp. 361-373) edited by Francisco Bandeira, Hossein Gharib, Airton Golbert, Luiz Griz and Manuel Faria. New York, NY, United States: Springer New York. doi: 10.1007/978-1-4614-8684-8_28

  • Dekker Nitert, M., Barrett, H. L., de Jersey, S., Matusiak, K., McIntyre, H. D. and Callaway, L. K. (2014). Preconception care and barriers to addressing overweight and obesity: a focus on weight loss advice and weight loss strategies. Handbook of diet and nutrition in the menstrual cycle, periconception and fertility. (pp. 327-342) edited by HollinsMartin, C, VanDenAkker, O, Martin, C and Preedy, VR. Wageningen, Netherlands: Wageningen Academic Publishers. doi: 10.3920/978-90-8686-767-7.020

  • McIntyre, Harold David, Lowe, Lynn P., Dyer, Alan R. and Metzger, Boyd E. (2012). Obesity in pregnancy: data from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. Maternal obesity and pregnancy. (pp. 271-281) edited by Per Glud Ovesen and Dorte Møller Jensen. Heidelberg, Germany: Springer. doi: 10.1007/978-3-642-25023-1_17

Journal Article

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Completed Supervision