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Professor Istvan Toth

Professor

School of Chemistry and Molecular Biosciences
Faculty of Science
i.toth@uq.edu.au
+61 7 334 69892

Overview

Professor Tóth’s major research interests are: drug delivery, immunoadjuvants, carbohydrates, lipids, peptides, nucleosides, and nucleotides. This research has attracted over $60 million in competitive grants, research contracts and investment funds in the past 10 years.

Professor István Tóth is an Australian Research Council Australian Professorial Fellow; Chair in Biological Chemistry & Professor of Pharmacy at The University of Queensland (UQ), Brisbane, Australia; and Affiliated Professorial Research Fellow and Group Leader at the Institute of Molecular Biosciences, UQ. He graduated with a degree in Chemical Engineering from the Technical University, Budapest, Hungary (1969) and was awarded his PhD (1972) for his Alkaloid Chemistry research. Professor Tóth undertook a postdoctoral fellowship at Carleton University, Ottawa Canada before returning to Hungary to work as a Research Associate (1977-82), then Scientific Group Leader (1982-87) at the Central Research Institute for Chemistry, Hungarian Academy of Science where he earned his Candidate of Science (C.Sc., 1979). He joined the School of Pharmacy at the University of London in 1987 as a Senior Lecturer and Royal Society sponsored Senior Research Fellow. He became a Reader in Medicinal Organic Chemistry in 1994 and was awarded a Doctorate of Science (D.Sc., 1994) for his work in Drug Delivery (Hungarian Academy of Sciences), before relocating to the University of Queensland in 1998 where he has built a productive research group (presently 30 members). Professor Tóth was a visiting professor at the School of Pharmacy, University of London (1994-2004) and at the Department of Bioengineering and Therapeutic Science, University of California, San Francisco (2011-2013).

Professor Tóth has over 300 peer-reviewed publications, 43 patents, and an excellent track record in research commercialisation. He is a one of key founders of Alchemia (ASX listed), Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development). Professor Tóth is also a Scientific Advisory Board Member of Implicit Bioscience Pty Ltd. Brisbane, Australia, and Proxima Concept Ltd, London, UK.

Professor Tóth is an elected RACI Fellow and Fellow of the Queensland Academy of Arts and Sciences. In 2009 he was awarded the Adrian Albert award for sustained and outstanding research in medicinal biochemistry, and a Business/Higher Education Round Table (BHERT) Award for Outstanding Achievement in International Collaborative Research and Development. Professor Tóth was appointed as a member of the ARC College of Experts (2008-2010). He was the founding (2007) then the elected (2008-2009) President of the Australian Chapter of Controlled Release Society. He is the Editor in Chief of Current Drug Delivery and Drug Delivery Letters, Associate Editor of Medicinal Chemistry; and the Board Member of Mini Reviews in Medicinal Chemistry, Open Drug Delivery, Open Medicinal Chemistry, and Current Patents in Drug Delivery.

Qualifications

  • Bachelor of Science, Bud
  • Doctor of Science, Bud
  • Diploma of Education (Science) (1969), Bud
  • Chem. Eng. Dipl. Medicinal Chemistry (1969), Bud
  • Doctor of Philosophy, Bud

Publications

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Grants

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Supervision

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Publications

Featured Publications

Book

Book Chapter

  • Bioconjugated materials in the development of subunit vaccines

    Fan, Jingyi, Toth, Istvan and Stephenson, Rachel J. (2023). Bioconjugated materials in the development of subunit vaccines. Comprehensive analytical chemistry. (pp. *-*) Amsterdam, Netherlands: Elsevier. doi: 10.1016/bs.coac.2023.02.005

  • Current Prospects in Peptide-Based Subunit Nanovaccines

    Koirala, Prashamsa, Bashiri, Sahra, Toth, Istvan and Skwarczynski, Mariusz (2022). Current Prospects in Peptide-Based Subunit Nanovaccines. Methods in Molecular Biology. (pp. 309-338) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1892-9_16

  • Developments in vaccine adjuvants

    Firdaus, Farrhana Ziana, Skwarczynski, Mariusz and Toth, Istvan (2022). Developments in vaccine adjuvants. Vaccine Design: Methods and Protocols, Volume 3: Resources for Vaccine Development. (pp. 145-178) edited by Sunil Thomas. New York, United States: Humana Press. doi: 10.1007/978-1-0716-1892-9_8

  • Liposomes for the delivery of lipopeptide vaccines

    Yang, Jieru, Azuar, Armira, Toth, Istvan and Skwarczynski, Mariusz (2022). Liposomes for the delivery of lipopeptide vaccines. Methods in Molecular Biology. (pp. 295-307) New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1892-9_15

  • Polymer–Peptide Conjugate Vaccine for Oral Immunization

    Faruck, Mohammad Omer, Skwarczynski, Mariusz and Toth, Istvan (2022). Polymer–Peptide Conjugate Vaccine for Oral Immunization. Methods in Molecular Biology. (pp. 35-44) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1892-9_3

  • Preparation of Trimethyl Chitosan-Based Polyelectrolyte Complexes for Peptide Subunit Vaccine Delivery

    Zhao, Lili, Bashiri, Sahra, Toth, Istvan and Skwarczynski, Mariusz (2022). Preparation of Trimethyl Chitosan-Based Polyelectrolyte Complexes for Peptide Subunit Vaccine Delivery. Methods in Molecular Biology. (pp. 141-149) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1900-1_9

  • Double conjugation using mercapto-acryloyl and alkyne-azide reactions for the synthesis of branched multiantigenic vaccine candidates

    Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2021). Double conjugation using mercapto-acryloyl and alkyne-azide reactions for the synthesis of branched multiantigenic vaccine candidates. Peptide conjugation: methods and protocols. (pp. 141-150) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1617-8_13

  • Nanocarrier-based vaccine delivery systems for synthetic peptide vaccines

    Madge, Harrison Y.R., Stephenson, Rachel J. and Toth, Istvan (2021). Nanocarrier-based vaccine delivery systems for synthetic peptide vaccines. Handbook of nanotechnology applications: environment, energy, agriculture and medicine. (pp. 509-535) edited by Woei Jye Lau, Kajornsak Faungnawakij, Kuakoon Piyachomkwan and Uracha Rungsardthong Ruktanonchai. Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-821506-7.00020-x

  • Peptide-Polymer Conjugation Via Copper-Catalyzed Alkyne-Azide 1,3-Dipolar Cycloaddition

    Hussein, Waleed M., Toth, Istvan and Skwarczynski, Mariusz (2021). Peptide-Polymer Conjugation Via Copper-Catalyzed Alkyne-Azide 1,3-Dipolar Cycloaddition. Methods in Molecular Biology. (pp. 1-7) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1617-8_1

  • Peptide-pegylated lipid conjugation via copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition

    Hussein, Waleed M. and Toth, Istvan (2021). Peptide-pegylated lipid conjugation via copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition. Peptide conjugation: methods and protocols. (pp. 57-64) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1617-8_6

  • Preface

    Hussein, Waleed H., Stephenson, Rachel J. and Toth, Istvan (2021). Preface. Peptide conjugation: methods and protocols. (pp. v-v) New York, NY USA: Humana Press.

  • An isodipeptide building block for microwave-assisted solid-phase synthesis of difficult sequence-containing peptides

    Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2020). An isodipeptide building block for microwave-assisted solid-phase synthesis of difficult sequence-containing peptides. Peptide synthesis: methods and protocols. (pp. 139-150) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY, United States: Springer. doi: 10.1007/978-1-0716-0227-0_9

  • Preface

    Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2020). Preface. Peptide synthesis: methods and protocols. (pp. v-v) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY, United States: Springer.

  • Peptide-based vaccines

    Nevagi, Reshma J., Toth, Istvan and Skwarczynski, Mariusz (2018). Peptide-based vaccines. Peptide applications in biomedicine, biotechnology and bioengineering. (pp. 327-358) edited by Sotirios Koutsopoulos. Duxford, United Kingdom: Woodhead Publishing (Elsevier). doi: 10.1016/B978-0-08-100736-5.00012-0

  • Liposomes as a vaccine delivery system

    Marasini, N., Ghaffar, K.A., Skwarczynski, M. and Toth, I. (2017). Liposomes as a vaccine delivery system. Micro and Nanotechnology in Vaccine Development. (pp. 221-239) edited by Mariusz Skwarczynski and Istvan Toth. Kidlington, Oxford, United Kingdom: Elsevier. doi: 10.1016/B978-0-323-39981-4.00012-9

  • Micro- and Nanotechnology in Vaccine Development - Introduction

    Skwarczynski, Mariusz and Toth, Istvan (2017). Micro- and Nanotechnology in Vaccine Development - Introduction. Micro- and Nanotechnology in Vaccine Development . (pp. XVII-XVIII) edited by Skwarczynski, M. and Toth, I.. Kidlington, Oxford, United Kingdom: Elsevier Science.

  • Current boundaries in the formulation of lipid based delivery systems

    Eskandari, Sharareh, Stephenson, Rachel and Toth, Istvan (2016). Current boundaries in the formulation of lipid based delivery systems. Liposomal delivery systems: advances and challenges. (pp. 160-174) edited by Abdus Samad, Sarwar Beg and Iram Nazish. London, United Kingdom: Future Medicine. doi: 10.4155/9781910419083

  • Introduction

    Skwarczynski, Mariusz and Toth, Istvan (2016). Introduction. Micro and nanotechnology in vaccine development: micro and nano technologies. (pp. xvii-xviii) edited by Mariusz Skwarczynski and Istvan Toth. Oxford, United Kingdom: Elsevier. doi: 10.1016/B978-0-323-39981-4.00027-0

  • The use of microwave-assisted solid-phase peptide synthesis and click chemistry for the synthesis of vaccine candidates against hookworm infection

    Ahmad Fuaad, Abdullah A. H., Skwarczynski, Mariusz and Toth, Istvan (2016). The use of microwave-assisted solid-phase peptide synthesis and click chemistry for the synthesis of vaccine candidates against hookworm infection. Vaccine design: methods and protocols: volume 1: vaccines for human diseases. (pp. 639-653) edited by Thomas, Sunil. New York, NY United States: Springer New York. doi: 10.1007/978-1-4939-3387-7_36

  • Lipo-peptides/saccharides in peptide vaccine delivery

    Skwarczynskim, Mariusz, Zaman, Mehfuz and Toth, Istvan (2013). Lipo-peptides/saccharides in peptide vaccine delivery. Handbook of biologically active peptides. (pp. 571-579) edited by Abba J. Kastin. Amsterdam, Netherlands: Academic Press/Elsevier. doi: 10.1016/B978-0-12-385095-9.00078-6

  • Lipid core peptide system for self-adjuvanting synthetic vaccine delivery

    Skwarczynski, Mariusz and Toth, Istvan (2011). Lipid core peptide system for self-adjuvanting synthetic vaccine delivery. Bioconjugation protocols: Strategies and methods. (pp. 297-308) edited by Sonny S. S. Mark. New York , U.S.A: Humana Press. doi: 10.1007/978-1-61779-151-2_18

  • Lipopeptide-based vaccines

    Jackson, David C., Chua, Brendon Y., Brown, Lorena E., Moyle, Peter and Toth, Istvan (2010). Lipopeptide-based vaccines. New generation vaccines. (pp. 315-326) edited by Myron M. Levine. New York, U.S.A.; London, U.K.: Informa Healthcare. doi: 10.3109/9781420060744-32

  • Toll-like receptor 2 mediated dendritic cell activation: Key target for lipopeptide vaccines design

    Zaman, Mehfuz, Skwarczynski, Marius and Toth, Istvan (2010). Toll-like receptor 2 mediated dendritic cell activation: Key target for lipopeptide vaccines design. Dendritic Cells: Types, Life Cycles and Biological Functions. (pp. 63-80) edited by Lorraine C. Welles. New York, NY, U.S.A.: Nova Science Publishers.

  • Strategies in oral immunization

    Simerska, Pavla, Moyle, Peter M., Olive, Colleen and Toth, Istvan (2009). Strategies in oral immunization. Oral Delivery of Macromolecular Drugs: Barriers, Strategies and Future Trends. (pp. 195-222) edited by Bernkop-Schnurch, Andreas. New York, United States: Springer. doi: 10.1007/978-1-4419-0200-9_11

  • Modification of peptides and other drugs using lipoamino acids and sugars

    Blanchfield, J. T. and Toth, I. (2005). Modification of peptides and other drugs using lipoamino acids and sugars. Methods in Molecular Biology: Peptide Synthesis and Applications. (pp. 45-61) edited by John Howl. New Jersey: Humana Press. doi: 10.1385/1-59259-877-3:045

  • Drug delivery systems utilizing lipids and sugars

    Wong, A., Bender, V. and Toth, I. (2003). Drug delivery systems utilizing lipids and sugars. Molecular Pathomechanisms and New Trends in Drug Research. (pp. 599-612) edited by G. Keri and I. Toth. London & New York: Taylor & Francis. doi: 10.1201/9780203219973.ch45

  • Introduction: A breakthrough in modern drug research

    Keri, G. and Toth, I. (2003). Introduction: A breakthrough in modern drug research. Molecular Pathomechanisms and New Trends in Drug Research. (pp. 1-4) edited by G. Keri and I. Toth. London & New York: Taylor & Francis.

  • Lipoamino acid based glycoconjugates for peptide and drug delivery

    Falconer, Robert A. and Toth, Istvan (2002). Lipoamino acid based glycoconjugates for peptide and drug delivery. Peptides for the New Millennium. (pp. 77-78) Dordrecht, The Netherlands: Kluwer Academic Publishers. doi: 10.1007/0-306-46881-6_310

  • Lipoamino Acid and Liposaccharide Conjugated Peptides: Enhancement of Bioavailability

    Chan, Yiu-Ngok, Wong, Allan K. and Toth, Istvan (2001). Lipoamino Acid and Liposaccharide Conjugated Peptides: Enhancement of Bioavailability. Peptides: The Wave of the Future. (pp. 955-956) Dordrecht, The Netherlands: Springer Netherlands. doi: 10.1007/978-94-010-0464-0_445

  • Liposaccharides: Utilisation for peptide delivery and for enhancing synthetic peptide immunogenicity

    Toth, Istvan, McGeary, Ross, Blanchfield, Joanne, Rhee, Handoo, Alewood, Paul, Adams, David and Good, Michael (2001). Liposaccharides: Utilisation for peptide delivery and for enhancing synthetic peptide immunogenicity. Peptides: The Wave of the Future. (pp. 937-939) edited by Michal Lebl and Richard A. Houghten. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/978-94-010-0464-0_437

  • Lipidic amino acid based synthetic peptide vaccine adjuvant

    Toth, Istvan, Danton, Malcolm, Reid, Ronald E., Zhong, Guangming, Brunham, Robert, Tóth, Gábor K. and Gibbons, William A. (1993). Lipidic amino acid based synthetic peptide vaccine adjuvant. Peptides 1992. (pp. 823-824) Dordrecht, The Netherlands: Springer Netherlands. doi: 10.1007/978-94-011-1470-7_377

  • Synthesis and biological activity of heteroalkyl lipidic amino acids

    del Olmo, Esther, Toth, Istvan, Fonteh, Alfred N. and Gibbons, William A. (1992). Synthesis and biological activity of heteroalkyl lipidic amino acids. Peptides. (pp. 452-453) Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/978-94-011-2264-1_171

  • Synthesis of lipidic peptide conjugates of nucleoside antiviral and cytostatic agents

    Hussain, Rohanah, Toth, Istvan and Gibbons, William A. (1992). Synthesis of lipidic peptide conjugates of nucleoside antiviral and cytostatic agents. Peptides. (pp. 450-451) Dordrecht, The Netherlands: Springer Netherlands. doi: 10.1007/978-94-011-2264-1_170

Journal Article

Conference Publication

Edited Outputs

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Polymers as a nanoparticulate adjuvant and vaccine delivery system

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • Delivery systems for novel vaccine candidates against infectious diseases

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • Nanovaccines against infectious diseases

    Doctor Philosophy — Associate Advisor

    Other advisors:

  • Design and Synthesis of Self-adjuvanting and Pathogen-Selective Glycoconjugate Group A Streptococcus Vaccines

    Doctor Philosophy — Associate Advisor

    Other advisors:

  • Novel Vaccine Designs of Adjuvants and Delivery Systems against Infectious Diseases

    Doctor Philosophy — Associate Advisor

    Other advisors:

  • Polymers and peptides for vaccine delivery.

    Doctor Philosophy — Associate Advisor

    Other advisors:

  • Poly(hydrophobic amino acids) as immune stimulators.

    Doctor Philosophy — Associate Advisor

    Other advisors:

  • Targeted CRISPR delivery platform

    Doctor Philosophy — Associate Advisor

    Other advisors:

  • Development of a multicomponent, targeted gene delivery platform

    Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision

This staff member is a UQ Expert for media in the following fields:

Chemistry - sugar, Chemistry - lipid, Chemistry - medicinal, Chemistry - peptide, Sugar chemistry, Immunisation, Vaccines - oral administration, Drug delivery, Lipid chemistry, Medicinal chemistry, Peptide chemistry, Drug - oral administration, Peptide drug delivery, Genes and vaccines, Vaccines and genes, Oral administration of vaccines, Chemistry - sugar, Chemistry - lipid, Chemistry - medicinal, Chemistry - peptide, Sugar chemistry, Immunisation, Vaccines - oral administration, Drug delivery, Lipid chemistry, Medicinal chemistry, Peptide chemistry, Drug - oral administration, Peptide drug delivery, Genes and vaccines, Vaccines and genes, Oral administration of vaccines

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ResearcherID: C-1965-2013

ORCID: 0000-0002-4572-397X

Scopus ID: 7103307460

Google Scholar ID: CuUbPZkAAAAJ

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