The University of Queensland

Cdc25 family phosphatases in cancer

Gabrielli, Brian and Burgess, Andrew (2016). Cdc25 family phosphatases in cancer. Protein tyrosine phosphatases in cancer. (pp. 283-306) edited by Benjamin G. Neel and Nicholas K. Tonks. New York, USA: Springer New York. doi: 10.1007/978-1-4939-3649-6_11

Cell cycle checkpoint and DNA damage response defects as anticancer targets: from molecular mechanisms to therapeutic opportunities.

Spoerri, Loredana, Oo, Zay Yar, Larsen, Jill E., Haass, Nikolas K., Gabrielli, Brian and Pavey, Sandra (2015). Cell cycle checkpoint and DNA damage response defects as anticancer targets: from molecular mechanisms to therapeutic opportunities.. Stress response pathways in cancer: from molecular targets to novel therapeutics. (pp. 29-49) edited by Georg T. Wondrak. Dordrecht: Springer Science+Business Media. doi: 10.1007/978-94-017-9421-3_3

Do Histone deacetylase inhibitors target cell cycle checkpoints that monitor heterochromatin structure?

Gabrielli, Brian G., Stevens, Frances and Beamish, Heather J. (2008). Do Histone deacetylase inhibitors target cell cycle checkpoints that monitor heterochromatin structure?. Checkpoint responses in cancer therapy. (pp. 291-309) edited by Wei Dai. The United States of America: Humana Press. doi: 10.1007/978-1-59745-274-8

Cell Cycle Targets of Histone Deacetylase Inhibitors

Gabrielli, Brian (2006). Cell Cycle Targets of Histone Deacetylase Inhibitors. Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions. (pp. 299-314) edited by Eric Verdin. Berlin: Humana Press.

Histone Deacetylase Inhibition as a Treatment of TRAIL-Resistant Cancers

Neuzil, J., Andera, L. and Gabrielli, B. (2005). Histone Deacetylase Inhibition as a Treatment of TRAIL-Resistant Cancers. Application of Apoptosis to Cancer Treatment. (pp. 271-291) edited by Mels Sluyser. Netherlands: Springer. doi: 10.1007/1-4020-3302-8_12

Analysis of Checkpoint Responses to Histone Deacetylase Inhibitors

Beamish, Heather, Warrener, Robyn and Gabrielli, Brian G. (2004). Analysis of Checkpoint Responses to Histone Deacetylase Inhibitors. Checkpoint Controls and Cancer: Vol. 2: Activation and Regulation Protocols. (pp. 245-259) edited by Axel H. Schonthal. Totowa, N.J.: Humana Press. doi: 10.1226/1588295001

Checkpoint kinase 1 inhibitor + low‐dose hydroxyurea efficiently kills BRAF inhibitor‐ and immune checkpoint inhibitor‐resistant melanomas

Zeng, Zhen, Ngo, Hung Long, Proctor, Martina, Rizos, Helen, Dolcetti, Riccardo, Cruz, Jazmina Gonzalez, Wells, James W. and Gabrielli, Brian (2023). Checkpoint kinase 1 inhibitor + low‐dose hydroxyurea efficiently kills BRAF inhibitor‐ and immune checkpoint inhibitor‐resistant melanomas. Pigment Cell & Melanoma Research. doi: 10.1111/pcmr.13120

Repurposing of commercially existing molecular target therapies to boost the clinical efficacy of immune checkpoint blockade

Sinha, Debottam, Moseley, Philip, Lu, Xuehan, Wright, Quentin, Gabrielli, Brian, Frazer, Ian H. and Cruz, Jazmina L. G. (2022). Repurposing of commercially existing molecular target therapies to boost the clinical efficacy of immune checkpoint blockade. Cancers, 14 (24) 6150, 1-26. doi: 10.3390/cancers14246150

Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression

Proctor, Martina, Gonzalez Cruz, Jazmina L., Daignault-Mill, Sheena M., Veitch, Margaret, Zeng, Bijun, Ehmann, Anna, Sabdia, Muhammed, Snell, Cameron, Keane, Colm, Dolcetti, Riccardo, Haass, Nikolas K., Wells, James W. and Gabrielli, Brian (2021). Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression. Cancers, 13 (15) 3733, 1-19. doi: 10.3390/cancers13153733

Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours

Fernando, Madushan, Duijf, Pascal H. G., Proctor, Martina, Stevenson, Alexander J., Ehmann, Anna, Vora, Shivam, Skalamera, Dubravka, Adams, Mark and Gabrielli, Brian (2021). Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours. Oncogenesis, 10 (5) 41, 41. doi: 10.1038/s41389-021-00329-8

Unexpected high levels of BRN2/POU3F2 expression in human dermal melanocytic nevi

Chitsazan, Arash, Lambie, Duncan, Ferguson, Blake, Handoko, Herlina Y., Gabrielli, Brian, Walker, Graeme J. and Boyle, Glen M. (2020). Unexpected high levels of BRN2/POU3F2 expression in human dermal melanocytic nevi. Journal of Investigative Dermatology, 140 (6), 1299-1302.e4. doi: 10.1016/j.jid.2019.12.007

Melanoma mutations modify melanocyte dynamics in co-culture with keratinocytes or fibroblasts

Škalamera, Dubravka, Stevenson, Alexander J., Ehmann, Anna, Ainger, Stephen A., Lanagan, Catherine, Sturm, Richard A. and Gabrielli, Brian (2019). Melanoma mutations modify melanocyte dynamics in co-culture with keratinocytes or fibroblasts. Journal of Cell Science, 132 (24) jcs234716, jcs234716. doi: 10.1242/jcs.234716

Multiple interaction nodes define the post-replication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load

Pavey, Sandra, Pinder, Alex, Fernando, Winnie, D'Arcy, Nicholas, Matigian, Nicholas, Skalamera, Dubravka, Lê Cao, Kim-Anh, Loo-Oey, Dorothy, Hill, Michelle M., Stark, Mitchell, Kimlin, Michael, Burgess, Andrew, Cloonan, Nicole, Sturm, Richard A. and Gabrielli, Brian (2019). Multiple interaction nodes define the post-replication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load. Molecular Oncology, 14 (1) 1878-0261.12601, 22-41. doi: 10.1002/1878-0261.12601

Everything in moderation: lessons learned by exploiting moderate replication stress in cancer

Nazareth, Deborah, Jones, Matthew J.K. and Gabrielli, Brian (2019). Everything in moderation: lessons learned by exploiting moderate replication stress in cancer. Cancers, 11 (9) 1320, 1320. doi: 10.3390/cancers11091320

Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine

Oo, Zay Yar, Proctor, Martina, Stevenson, Alexander J., Nazareth, Deborah, Fernando, Madushan, Daignault, Sheena M., Lanagan, Catherine, Walpole, Sebastian, Bonazzi, Vanessa, Škalamera, Dubravka, Snell, Cameron, Haass, Nikolas K., Larsen, Jill E. and Gabrielli, Brian (2019). Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine. Molecular Oncology, 13 (7) 1878-0261.12497, 1503-1518. doi: 10.1002/1878-0261.12497

Aurora kinases are a novel therapeutic target for HPV-positive head and neck cancers

Shaikh, Mushfiq H., Idris, Adi, Johnson, Newell W., Fallaha, Sora, Clarke, Daniel T.W., Martin, David, Morgan, Iain M., Gabrielli, Brian and McMillan, Nigel A. J. (2018). Aurora kinases are a novel therapeutic target for HPV-positive head and neck cancers. Oral Oncology, 86, 105-112. doi: 10.1016/j.oraloncology.2018.09.006

Pathway dysregulation analysis of the nucleotide excision repair mechanisms reveals it is not a common feature of melanomas

D’Arcy, Nicholas, Matigian, Nicholas, Lê Cao, Kim-Anh and Gabrielli, Brian (2018). Pathway dysregulation analysis of the nucleotide excision repair mechanisms reveals it is not a common feature of melanomas. Pigment Cell & Melanoma Research, 32 (2), 336-338. doi: 10.1111/pcmr.12740

CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer

Kalimutho, Murugan, Sinha, Debottam, Jeffery, Jessie, Nones, Katia, Srihari, Sriganesh, Fernando, Winnie C., Duijf, Pascal H. G., Vennin, Claire, Raninga, Prahlad, Nanayakkara, Devathri, Mittal, Deepak, Saunus, Jodi M., Lakhani, Sunil R., López, J Alejandro, Spring, Kevin J., Timpson, Paul, Gabrielli, Brian, Waddell, Nicola and Khanna, Kum Kum (2018). CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. EMBO Molecular Medicine, 10 (9) e8566, e8566. doi: 10.15252/emmm.201708566

Endogenous replication stress marks melanomas sensitive to CHEK1 inhibitors in vivo

Oo, Zay Yar, Stevenson, Alexander J., Proctor, Martina A., Daignault, Sheena M., Walpole, Sebastian, Lanagan, Catherine, Chen, James, Skalamera, Dubravka, Spoerri, Loredana, Ainger, Stephen, Sturm, Richard A, Haass, Nikolas K and Gabrielli, Brian (2018). Endogenous replication stress marks melanomas sensitive to CHEK1 inhibitors in vivo. Clinical Cancer Research, 24 (12), 2901-2912. doi: 10.1158/1078-0432.CCR-17-2701

Mechanism of action of the third generation benzopyrans and evaluation of their broad anti-cancer activity in vitro and in vivo

Stevenson, Alexander J., Ager, Eleanor I., Proctor, Martina A., Škalamera, Dubravka, Heaton, Andrew, Brown, David and Gabrielli, Brian G. (2018). Mechanism of action of the third generation benzopyrans and evaluation of their broad anti-cancer activity in vitro and in vivo. Scientific Reports, 8 (1) 22882, 5144. doi: 10.1038/s41598-018-22882-w

Discovery of thalicthuberine as a novel antimitotic agent from nature that disrupts microtubule dynamics and induces apoptosis in prostate cancer cells

Levrier, Claire, Rockstroh, Anja, Gabrielli, Brian, Kavallaris, Maria, Lehman, Melanie, Davis, Rohan A, Sadowski, Martin C and Nelson, Colleen C (2018). Discovery of thalicthuberine as a novel antimitotic agent from nature that disrupts microtubule dynamics and induces apoptosis in prostate cancer cells. Cell Cycle, 17 (5), 652-668. doi: 10.1080/15384101.2017.1356512

Acetylsalicylic acid governs the effect of sorafenib in RAS- mutant cancers

Hammerlindl, Heinz, Ravindran Menon, Dinoop, Hammerlindl, Sabrina, Emran, Abdullah Al, Torrano, Joachim, Sproesser, Katrin, Thakkar, Divya, Xiao, Min, Atkinson, Victoria G., Gabrielli, Brian, Haass, Nikolas K., Herlyn, Meenhard, Krepler, Clemens and Schaider, Helmut (2018). Acetylsalicylic acid governs the effect of sorafenib in RAS- mutant cancers. Clinical Cancer Research, 24 (5), 1090-1102. doi: 10.1158/1078-0432.CCR-16-2118

Distinct histone modifications denote early stress-induced drug tolerance in cancer

Emran, Abdullah Al, Marzese, Diego M., Menon, Dinoop Ravindran, Stark, Mitchell S., Torrano, Joachim, Hammerlindl, Heinz, Zhang, Gao, Brafford, Patricia, Salomon, Matthew P., Nelson, Nellie, Hammerlindl, Sabrina, Gupta, Deepesh, Mills, Gordon B., Lu, Yiling, Sturm, Richard A., Flaherty, Keith, Hoon, Dave S. B., Gabrielli, Brian, Herlyn, Meenhard and Schaider, Helmut (2017). Distinct histone modifications denote early stress-induced drug tolerance in cancer. Oncotarget, 9 (9), 8206-8222. doi: 10.18632/oncotarget.23654

Keratinocyte sonic hedgehog up-regulation drives the development of giant congenital nevi via paracrine endothelin-1 secretion

Chitsazan, Arash, Ferguson, Blake, Villani, Rehan, Handoko, Herlina Y, Mukhopadhyay, Pamela, Gabrielli, Brian, Mooi, Wolter J, Soyer, H Peter, Lambie, Duncan, Khosrotehrani, Kiarash, Morahan, Grant and Walker, Graeme J (2017). Keratinocyte sonic hedgehog up-regulation drives the development of giant congenital nevi via paracrine endothelin-1 secretion. The Journal of investigative dermatology, 138 (4), 893-902. doi: 10.1016/j.jid.2017.10.032

Inhibition of Aurora A and Aurora B Is Required for the Sensitivity of HPV-Driven Cervical Cancers to Aurora Kinase Inhibitors

Martin, David, Fallaha, Sora, Proctor, Martina, Stevenson, Alexander, Perrin, Lewis, McMillan, Nigel and Gabrielli, Brian (2017). Inhibition of Aurora A and Aurora B Is Required for the Sensitivity of HPV-Driven Cervical Cancers to Aurora Kinase Inhibitors. Molecular Cancer Therapeutics, 16 (9), 1934-1941. doi: 10.1158/1535-7163.MCT-17-0159

Cell cycle-tailored targeting of metastatic melanoma: challenges and opportunities

Haass, Nikolas K. and Gabrielli, Brian (2017). Cell cycle-tailored targeting of metastatic melanoma: challenges and opportunities. Experimental Dermatology, 26 (7), 649-655. doi: 10.1111/exd.13303

Genome-wide overexpression screen identifies genes able to bypass p16-mediated senescence in melanoma

Lee, Won Jae, Skalamera, Dubravka, Dahmer-Heath, Mareike, Shakhbazov, Konstanin, Ranall, Max V., Fox, Carly, Lambie, Duncan, Stevenson, Alexander J., Yaswen, Paul, Gonda, Thomas J. and Gabrielli, Brian (2017). Genome-wide overexpression screen identifies genes able to bypass p16-mediated senescence in melanoma. SLAS Discovery, 22 (3), 298-308. doi: 10.1177/1087057116679592

6α-Acetoxyanopterine: a novel structure class of mitotic inhibitor disrupting microtubule dynamics in prostate cancer cells

Levrier, Claire, Sadowski, Martin C., Rockstroh, Anja, Gabrielli, Brian, Kavallaris, Maria, Lehman, Melanie, Davis, Rohan A. and Nelson, Colleen C. (2017). 6α-Acetoxyanopterine: a novel structure class of mitotic inhibitor disrupting microtubule dynamics in prostate cancer cells. Molecular Cancer Therapeutics, 16 (1), 3-15. doi: 10.1158/1535-7163.MCT-16-0325

Topoisomerase II inhibitors and poisons, and the influence of cell cycle checkpoints

D'Arcy, Nicholas and Gabrielli, Brian (2017). Topoisomerase II inhibitors and poisons, and the influence of cell cycle checkpoints. Current Medicinal Chemistry, 24 (15), 1504-1519. doi: 10.2174/0929867323666161205122613

Genome-wide gain-of-function screen for genes that induce epithelial-to-mesenchymal transition in breast cancer

Skalamera, Dubravka, Dahmer-Heath, Mareike, Stevenson, Alexander J., Pinto, Cletus, Shah, Esha T., Daignault, Sheena M., Said, Nur Akmarina B. M., Davis, Melissa, Haass, Nikolas K., Williams, Elizabeth D., Hollier, Brett G., Thompson, Erik W., Gabrielli, Brian and Gonda, Thomas J. (2016). Genome-wide gain-of-function screen for genes that induce epithelial-to-mesenchymal transition in breast cancer. Oncotarget, 7 (38), 61000-61020. doi: 10.18632/oncotarget.11314

Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation

Fox, Carly, Lambie, Duncan, Wilmott, James S., Pinder, Alex, Pavey, Sandra, Lê Cao, Kim-Anh, Akalin, Taner, Karaarslan, Isil Kilinc, Ozdemir, Fezal, Scolyer, Richard A., Yamada, Miko, Soyer, H. Peter, Schaider, Helmut and Gabrielli, Brian (2016). Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation. Pigment Cell and Melanoma Research, 29 (4), 444-452. doi: 10.1111/pcmr.12489

A mutation in the Cdon gene potentiates congenital nevus development mediated by NRASQ61K

Chitsazan, Arash, Ferguson, Blake, Ram, Ramesh, Mukhopadhyay, Pamela, Handoko, Herlina Y., Gabrielli, Brian, Soyer, Peter H, Morahan, Grant and Walker, Graeme J. (2016). A mutation in the Cdon gene potentiates congenital nevus development mediated by NRASQ61K. Pigment Cell and Melanoma Research, 29 (4), 459-464. doi: 10.1111/pcmr.12487

Cell cycle phase-specific drug resistance as an escape mechanism of melanoma cells

Beaumont, Kimberley A., Hill, David S., Daignault, Sheena M., Lui, Goldie Y. L., Sharp, Danae M., Gabrielli, Brian, Weninger, Wolfgang and Haass, Nikolas K. (2016). Cell cycle phase-specific drug resistance as an escape mechanism of melanoma cells. Journal of Investigative Dermatology, 136 (7), 1479-1489. doi: 10.1016/j.jid.2016.02.805

A novel ATM-dependent checkpoint defect distinct from loss of function mutation promotes genomic instability in melanoma

Spoerri, Loredana, Brooks, Kelly, Chia, KeeMing, Grossman, Gavriel, Ellis, Jonathan J., Dahmer-Heath, Mareike, Skalamera, Dubravka, Pavey, Sandra, Burmeister, Bryan and Gabrielli, Brian (2016). A novel ATM-dependent checkpoint defect distinct from loss of function mutation promotes genomic instability in melanoma. Pigment Cell and Melanoma Research, 29 (3), 329-339. doi: 10.1111/pcmr.12466

In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis

Vaidyanathan, Srividya, Cato, Kathleen, Tang, Lu, Pavey, Sandra, Haass, Nikolas K., Gabrielli, Brian G. and Duijf, Pascal H. G. (2016). In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis. Oncogene, 35 (41), 5446-5455. doi: 10.1038/onc.2016.94

Self-renewal and high proliferative colony forming capacity of late-outgrowth endothelial progenitors is regulated by cyclin-dependent kinase inhibitors driven by notch signaling

Patel, Jatin, Wong, Ho Yi, Wang, Weili, Alexis, Josue, Shafiee, Abbas, Stevenson, Alexander J., Gabrielli, Brian, Fisk, Nicholas M. and Khosrotehrani, Kiarash (2016). Self-renewal and high proliferative colony forming capacity of late-outgrowth endothelial progenitors is regulated by cyclin-dependent kinase inhibitors driven by notch signaling. Stem Cells, 34 (4), 902-912. doi: 10.1002/stem.2262

Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer

Harrington, Brittney S., He, Yaowu, Davies, Claire M., Wallace, Sarah J., Adams, Mark N., Beaven, Elizabeth A., Roche, Deborah K., Kennedy, Catherine, Chetty, Naven P., Crandon, Alexander J., Flatley, Christopher, Oliveira, Niara B., Shannon, Catherine M., deFazio, Anna, Tinker, Anna V., Gilks, C. Blake, Gabrielli, Brian, Brennan, Donal J., Coward, Jermaine I., Armes, Jane E., Perrin, Lewis C. and Hooper, John D. (2016). Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer. British Journal of Cancer, 114 (4), 417-426. doi: 10.1038/bjc.2015.471

A distinct expression profile separates Turkish and Australian melanocytic naevi

Fox, Carly, Schaider, Helmut, Akalin, Taner, Turkmen, Meltem, Sturm, Rick, Lambie, Duncan, Karaarslan, Isil K., Soyer, H. Peter, Ozdemir, Fezal and Gabrielli, Brian (2016). A distinct expression profile separates Turkish and Australian melanocytic naevi. Histopathology, 69 (1), 151-154. doi: 10.1111/his.12906

Aurora A is critical for survival in HPV-transformed cervical cancer

Gabrielli, Brian, Bokhari, Fawzi, Ranall, Max V., Oo, Zay Yar, Stevenson, Alexander J., Wang, Weili, Murrell, Melanie, Shaikh, Mushfiq, Fallaha, Sora, Clarke, Daniel, Kelly, Madison, Sedelies, Karin, Christensen, Melinda, McKee, Sara, Leggatt, Graham, Leo, Paul, Skalamera, Dubravka, Soyer, H. Peter, Gonda, Thomas J. and McMillan, Nigel A. J. (2015). Aurora A is critical for survival in HPV-transformed cervical cancer. Molecular Cancer Therapeutics, 14 (12), 2753-2761. doi: 10.1158/1535-7163.MCT-15-0506

A stress-induced early innate response causes multidrug tolerance in melanoma

Ravindran Menon, D., Das, S., Krepler, C., Vultur, A., Rinner, B., Schauer, S., Kashofer, K., Wagner, K., Zhang, G., Bonyadi Rad, E., Haass, N. K., Soyer, H. P., Gabrielli, B., Somasundaram, R., Hoefler, G., Herlyn, M. and Schaider, H. (2015). A stress-induced early innate response causes multidrug tolerance in melanoma. Oncogene, 34 (34), 4448-4459. doi: 10.1038/onc.2014.372

Corrigendum: a stress-induced early innate response causes multidrug tolerance in melanoma (vol 34, pg 4448, 2015)

Menon, D. Ravindran, Das, S., Krepler, C., Vultur, A., Rinner, B., Schauer, S., Kashofer, K., Wagner, K., Zhang, G., Rad, E. Bonyadi, Haass, N. K., Soyer, H. P., Gabrielli, B., Somasundaram, R., Hoefler, G., Herlyn, M. and Schaider, H. (2015). Corrigendum: a stress-induced early innate response causes multidrug tolerance in melanoma (vol 34, pg 4448, 2015). Oncogene, 34 (34), 4545-4545. doi: 10.1038/onc.2014.432

JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase

Pinder, Alex, Loo, Dorothy, Harrington, Brittney, Oakes, Vanessa, Hill, Michelle M. and Gabrielli, Brian (2015). JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase. Cellular Signalling, 27 (11), 2296-2303. doi: 10.1016/j.cellsig.2015.08.009

Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

Irvine, Katharine M., Skoien, Richard, Bokil, Nilesh J., Melino, Michelle, Thomas, Gethin P., Loo, Dorothy, Gabrielli, Brian, Hill, Michelle M., Sweet, Matthew J., Clouston, Andrew D. and Powell, Elizabeth E. (2014). Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration. World Journal of Gastroenterology, 20 (47), 17851-17862. doi: 10.3748/wjg.v20.i47.17851

DCT protects human melanocytic cells from UVR and ROS damage and increases cell viability

Ainger, Stephen A., Yong, Xuan L., Wong, Shu S., Skalamera, Dubravka, Gabrielli, Brian, Leonard, J. Helen and Sturm, Richard A. (2014). DCT protects human melanocytic cells from UVR and ROS damage and increases cell viability. Experimental Dermatology, 23 (12), 916-921. doi: 10.1111/exd.12574

Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle

Oakes, Vanessa, Wang, Weili, Harrington, Brittney, Lee, Won Jae, Beamish, Heather, Chia, Kee Ming, Pinder, Alex, Goto, Hidemasa, Inagaki, Masaki, Pavey, Sandra and Gabrielli, Brian (2014). Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle. Cell Cycle, 13 (20), 3302-3311. doi: 10.4161/15384101.2014.949111

Decatenation checkpoint defective melanomas are dependent on PI3K for survival

Brooks, Kelly, Ranall, Max, Spoerri, Loredana, Stevenson, Alex, Gunasingh, Gency, Pavey, Sandra, Meunier, Fred, Gonda, Thomas J. and Gabrielli, Brian (2014). Decatenation checkpoint defective melanomas are dependent on PI3K for survival. Pigment Cell and Melanoma Research, 27 (5), 813-821. doi: 10.1111/pcmr.12268

Rapid mapping of interactions between human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy

Sierecki, Emma, Stevers, Loes M., Giles, Nichole, Polinkovsky, Mark E., Moustaqil, Mehdi, Mureev, Sergey, Johnston, Wayne A., Dahmer-Heath, Mareike, Skalamera, Duka, Gonda, Thomas J., Gabrielli, Brian, Collins, Brett M., Alexandrov, Kirill and Gambin, Yann (2014). Rapid mapping of interactions between human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy. Molecular and Cellular Proteomics, 13 (9), 2233-2245. doi: 10.1074/mcp.M113.037275

Phenotypic characterization of nevus and tumor patterns in MITF E318K mutation carrier melanoma patients

Sturm, Richard A., Fox, Carly, McClenahan, Phil, Jagirdar, Kasturee, Ibarrola-Villava, Maider, Banan, Parastoo, Abbott, Nicola C., Ribas, Gloria, Gabrielli, Brian, Duffy, David L. and Soyer, H. Peter (2014). Phenotypic characterization of nevus and tumor patterns in MITF E318K mutation carrier melanoma patients. Journal of Investigative Dermatology, 134 (1), 141-149. doi: 10.1038/jid.2013.272

DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.

Pavey, Sandra, Spoerri, Loredana, Haass, Nikolas K. and Gabrielli, Brian (2013). DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.. Pigment Cell and Melanoma Research, 26 (6), 805-816. doi: 10.1111/pcmr.12136

CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci

Boutros, Rose, Mondesert, Odile, Lorenzo, Corinne, Astuti, Puji, McArthur, Grant, Chircop, Megan, Ducommun, Bernard and Gabrielli, Brian (2013). CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci. PLoS One, 8 (7) e67822, e67822.1-e67822.13. doi: 10.1371/journal.pone.0067822

Defective decatenation checkpoint function is a common feature of melanoma

Brooks, Kelly, Chia, Kee Ming, Spoerri, Loredana, Mukhopadhyay, Pamela, Wigan, Matthew, Stark, Mitchell, Pavey, Sandra and Gabrielli, Brian (2013). Defective decatenation checkpoint function is a common feature of melanoma. Journal of Investigative Dermatology, 134 (1), 150-158. doi: 10.1038/jid.2013.264

Oxidative stress and cell senescence combine to cause maximal renal Tubular Epithelial Cell Dysfunction and loss in an in vitro Model of Kidney Disease

Small, David M., Bennett, Nigel C., Roy, Sandrine, Gabrielli, Brian G., Johnson, David W. and Gobe, Glenda C. (2013). Oxidative stress and cell senescence combine to cause maximal renal Tubular Epithelial Cell Dysfunction and loss in an in vitro Model of Kidney Disease. Nephron Experimental Nephrology, 122 (3-4), 123-130. doi: 10.1159/000350726

Truncated MEK1 is required for transient activation of MAPK signalling in G2 phase cells

Pike, Tanya, Widberg, Charlotte, Goodall, Andrew, Payne, Elizabeth, Giles, Nichole, Hancock, John and Gabrielli, Brian (2013). Truncated MEK1 is required for transient activation of MAPK signalling in G2 phase cells. Cellular Signalling, 25 (6), 1423-1428. doi: 10.1016/j.cellsig.2013.03.014

Similar, not the same: diverse roles and regulation of cyclin Es

Spoerri, Loredana and Gabrielli, Brian (2013). Similar, not the same: diverse roles and regulation of cyclin Es. Cell Cycle, 12 (5), 715-715. doi: 10.4161/cc.23909

A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress

Brooks, K., Oakes, V., Edwards, B., Ranall, M., Leo, P., Pavey, S., Pinder, A., Beamish, H., Mukhopadhyay, P., Lambie, D. and Gabrielli, B. (2013). A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress. Oncogene, 32 (6), 788-796. doi: 10.1038/onc.2012.72

MicroRNA-182-5-p targets a network of genes involved in DNA repair

Krishnan, Keerthana, Steptoe, Anita L., Martin, Hilary C., Wani, Shivangi, Nones, Katia, Waddell, Nic, Mariasegaram, Mythily, Simpson, Peter T., Lakhani, Sunil R., Gabrielli, Brian, Vlassov, Alexander, Cloonan, Nicole and Grimmond, Sean M. (2013). MicroRNA-182-5-p targets a network of genes involved in DNA repair. RNA, 19 (2), 230-242. doi: 10.1261/rna.034926.112

Generation of a genome scale lentiviral vector library for EF1α promoter-driven expression of hman ORFs and identification of human genes affecting viral titer

Skalamera, Dubravka, Dahmer, Mareike, Purdon, Amy S., Wilson, Benjamin M., Ranall, Max V., Blumenthal, Antje, Gabrielli, Brian and Gonda, Thomas J. (2012). Generation of a genome scale lentiviral vector library for EF1α promoter-driven expression of hman ORFs and identification of human genes affecting viral titer. PloS One, 7 (12) e51733, e51733.1-e51733.15. doi: 10.1371/journal.pone.0051733

A UVR-induced G2-phase checkpoint response to ssDNA gaps produced by replication fork bypass of unrepaired lesions is defective in melanoma

Wigan, Matthew, Pinder, Alex, Giles, Nichole, Pavey, Sandra, Burgess, Andrew, Wong, ShuShyan, Sturm, Rick A. and Gabrielli, Brian (2012). A UVR-induced G2-phase checkpoint response to ssDNA gaps produced by replication fork bypass of unrepaired lesions is defective in melanoma. Journal of Investigative Dermatology, 132 (6), 1681-1688. doi: 10.1038/jid.2012.41

Keeping replicative stress in Chk

Brooks, Kelly and Gabrielli, Brian (2012). Keeping replicative stress in Chk. Cell Cycle, 11 (11), 2039-2040. doi: 10.4161/cc.20425

Defective cell cycle checkpoints as targets for anti-cancer therapies

Gabrielli, Brian, Brooks, Kelly and Pavey, Sandra (2012). Defective cell cycle checkpoints as targets for anti-cancer therapies. Frontiers in Pharmacology, 3 (9) 9, 9.1-9.6. doi: 10.3389/fphar.2012.00009

Multiple melanoma susceptibility factors function in an ultraviolet radiation response pathway in skin

Giles, N., Pavey, S., Pinder, A. and Gabrielli, B. (2012). Multiple melanoma susceptibility factors function in an ultraviolet radiation response pathway in skin. British Journal of Dermatology, 166 (2), 362-371. doi: 10.1111/j.1365-2133.2011.10635.x

Histone deacetylase inhibitors disrupt the mitotic spindle assembly checkpoint by targeting histone and nonhistone proteins

Gabrielli, Brian and Brown, Melissa (2012). Histone deacetylase inhibitors disrupt the mitotic spindle assembly checkpoint by targeting histone and nonhistone proteins. Advances in Cancer Research, 116, 1-37. doi: 10.1016/B978-0-12-394387-3.00001-X

Histone deacetylase inhibitors in the generation of the anti-tumour immune response

Leggatt, Graham R. and Gabrielli, Brian (2012). Histone deacetylase inhibitors in the generation of the anti-tumour immune response. Immunology and Cell Biology, 90 (1), 33-38. doi: 10.1038/icb.2011.94

Finally, how histone deacetylase inhibitors disrupt mitosis!

Gabrielli, Brian, Chia, KeeMing and Warrener, Robyn (2011). Finally, how histone deacetylase inhibitors disrupt mitosis!. Cell Cycle, 10 (16), 2658-2661. doi: 10.4161/cc.10.16.16953

High-content imaging of neutral lipid droplets with 1,6-diphenylhexatriene

Ranall, Max V., Gabrielli, Brian g. and Gonda, Thomas J. (2011). High-content imaging of neutral lipid droplets with 1,6-diphenylhexatriene. Biotechniques, 51 (1), 35-42. doi: 10.2144/000113702

Phosphorylation of Cdc25B3 Ser169 regulates 14-3-3 binding to Ser151 and Cdc25B activity

Astuti, Puji and Gabrielli, Brian (2011). Phosphorylation of Cdc25B3 Ser169 regulates 14-3-3 binding to Ser151 and Cdc25B activity. Cell Cycle, 10 (12), 1960-1967. doi: 10.4161/cc.10.12.15819

A high-throughput platform for lentiviral overexpression screening of the human ORFeome

Škalamera, Dubravka, Ranall, Max V., Wilson, Benjamin M., Leo, Paul, Purdon, Amy S., Hyde, Carolyn, Nourbakhsh, Ehsan, Grimmond, Sean M., Barry, Simon C., Gabrielli, Brian and Gonda, Thomas J. (2011). A high-throughput platform for lentiviral overexpression screening of the human ORFeome. PLoS One, 6 (5) e20057, e20057.1-e20057.14. doi: 10.1371/journal.pone.0020057

Evidence for label-retaining tumour-initiating cells in human glioblastoma

Deleyrolle, Loic P., Harding, Angus, Cato, Kathleen, Siebzehnrubl, Florian A., Rahman, Maryam, Azari, Hassan, Olson, Sarah, Gabrielli, Brian, Osborne, Geoffrey, Vescovi, Angelo and Reynolds, Brent A. (2011). Evidence for label-retaining tumour-initiating cells in human glioblastoma. Brain, 134 (5), 1331-1343. doi: 10.1093/brain/awr081

CDC25B associates with a centrin 2-containing complex and is involved in maintaining centrosome integrity

Boutros, Rose, Lorenzo, Corinne, Mondesert, Odile, Jauneau, Alain, Oakes,Vanessa, Dozier, Christine, Gabrielli, Brian and Ducommun, Bernard (2011). CDC25B associates with a centrin 2-containing complex and is involved in maintaining centrosome integrity. Biology of the Cell, 103 (2), 55-68. doi: 10.1042/BC20100111

Mitotic phosphorylation of Cdc25B Ser(321) disrupts 14-3-3 binding to the high affinity Ser(323) site

Astuti, P, Boutros, R, Ducommun, B and Gabrielli, B (2010). Mitotic phosphorylation of Cdc25B Ser(321) disrupts 14-3-3 binding to the high affinity Ser(323) site. Journal of Biological Chemistry, 285 (45), 34364-34370. doi: 10.1074/jbc.M110.138412

Inhibition of histone deacetylase 3 produces mitotic defects independent of alterations in histone H3 lysine 9 acetylation and methylation

Warrener, Robyn, Chia, KeeMing, Warren, William D., Brooks, Kelly and Gabrielli, Brian (2010). Inhibition of histone deacetylase 3 produces mitotic defects independent of alterations in histone H3 lysine 9 acetylation and methylation. Molecular Pharmacology, 78 (3), 384-393. doi: 10.1124/mol.109.062976

The histone deacetylase inhibitor MGCD0103 has both deacetylase and microtubule inhibitory activity

Chia, K, Beamish, H, Jafferi, K and Gabrielli, B (2010). The histone deacetylase inhibitor MGCD0103 has both deacetylase and microtubule inhibitory activity. Molecular Pharmacology, 78 (3), 436-443. doi: 10.1124/mol.110.065169

Adaptation and validation of DNA synthesis detection by fluorescent dye derivatization for high throughput screening

Ranall, Max V., Gabrielli, Brian G. and Gonda, Thomas J. (2010). Adaptation and validation of DNA synthesis detection by fluorescent dye derivatization for high throughput screening. BioTechniques, 48 (5), 379-386. doi: 10.2144/000113410

MAPK pathway activation delays G(2)/M progression by destabilizing Cdc25B

Astuti, P, Pike, T, Widberg, C, Payne, E, Harding, A, Hancock, J and Gabrielli, B (2009). MAPK pathway activation delays G(2)/M progression by destabilizing Cdc25B. Journal of Biological Chemistry, 284 (49), 33781-33788. doi: 10.1074/jbc.M109.027516

Cyclin A/cdk2 regulates adenomatous polyposis coli-dependent mitotic spindle anchoring

Beamish, Heather, De Boer, Leonore, Giles, Nichole, Stevens, Frankie, Oakes, Vanessa and Gabrielli, Brian (2009). Cyclin A/cdk2 regulates adenomatous polyposis coli-dependent mitotic spindle anchoring. Journal of Biological Chemistry, 284 (42), 29015-29023. doi: 10.1074/jbc.M109.042820

CtBPs promote cell survival through the maintenance of mitotic fidelity

Bergman, Lee M., Birts, Charles N., Darley, Matthew, Gabrielli, Brian and Blaydes, Jeremy P. (2009). CtBPs promote cell survival through the maintenance of mitotic fidelity. Molecular and Cellular Biology, 29 (16), 4539-4551. doi: 10.1128/MCB.00439-09

The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition

Cloonan, Nicole, Brown, Mellissa K., Steptoe, Anita L., Wani, Shivangi, Chan, Wei Ling, Forrest, Alistair R. R., Kolle, Gabriel, Gabrielli, Brian and Grimmond, Sean M. (2008). The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition. Genome Biology, 9 (8) R127, R127.1-R127.14. doi: 10.1186/gb-2008-9-8-r127

Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events

De Boer, L., Oakes, V., Beamish, H., Giles, N., Stevens, F., Somodevilla Torres, M., DeSouza, C. and Gabrielli, B. (2008). Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events. Oncogene, 27 (31), 4261-4268. doi: 10.1038/onc.2008.74

Histone deacetylase inhibitors induce mitotic slippage

Stevens, Frances, Beamish, Heather J., Robyn Warrener and Gabrielli, Brian G. (2008). Histone deacetylase inhibitors induce mitotic slippage. Oncogene, 27 (10), 1345-1354. doi: 10.1038/sj.onc.1210779

Caffeine promotes apoptosis in mitotic spindle checkpoint-arrested cells

Gabrielli, B., Chau, Y. Q., Giles, N., Harding, A., Stevens, F. and Beamish, H. (2007). Caffeine promotes apoptosis in mitotic spindle checkpoint-arrested cells. The Journal of Biological Chemistry, 282 (10), 6954-6964. doi: 10.1074/jbc.M610104200

Inhibition of S/G(2) phase CDK4 reduces mitotic fidelity

Burgess, A, Wigan, M, Giles, N, DePinto, W, Gillespie, P, Stevens, F and Gabrielli, B (2006). Inhibition of S/G(2) phase CDK4 reduces mitotic fidelity. Journal of Biological Chemistry, 281 (15), 9987-9995. doi: 10.1074/jbc.M512714200

Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4(R24C/R24C)/TPras mice

Hacker, E., Muller, H. K., Irwin, N., Gabrielli, B., Lincoin, D., Pavey, S., Powell, M. B., Malumbres, M., Barbacid, M., Hayward, N. and Walker, G. (2006). Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4(R24C/R24C)/TPras mice. Cancer Research, 66 (6), 2946-2952. doi: 10.1158/0008-5472.CAN-05-3196

Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis

Fabbro, Megan, Zhou, Bin-Bing, Takahasi, Mikiko, Sarcevic, Boris, Lal, Preeti, Graham, Mark E., Gabrielli, Brian G., Robinson, Phillip J., Nigg, Erich A., Ono, Yoshitaka and Khanna, Kum Kum (2005). Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Developmental Cell, 9 (4), 477-488. doi: 10.1016/j.devcel.2005.09.003

RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin

Putral, L. N., Bywater, M. J., Gu, W. Y., Saunders, N. A., Gabrielli, B. G., Leggatt, G. R. and McMillan, N. A. J. (2005). RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin. Molecular Pharmacology, 68 (5), 1311-1319. doi: 10.1124/mol.105.014191

Histone-deacetylase inhibitors for the treatment of cancer

Lindemann, Ralph K., Gabrielli, Brian G. and Johnstone, Ricky W. (2004). Histone-deacetylase inhibitors for the treatment of cancer. Cell Cycle, 3 (6), 779-788. doi: 10.4161/cc.3.6.927

Analysis of checkpoint responses to histone deacetylase inhibitors

Beamish, Heather, Warrener, Robyn and Gabrielli, Brian G (2004). Analysis of checkpoint responses to histone deacetylase inhibitors. Methods in molecular biology (Clifton, N.J.), 281, 245-259. doi: 10.1385/1-59259-811-0:245

Analyzing checkpoint controls in human skin

Pavey, S. and Gabrielli, B. G. (2004). Analyzing checkpoint controls in human skin. Methods in Molecular Biology, 280 (1), 175-183.

Defining the chemotherapeutic targets of Histone Deacetylase inhibitors

Gabrielli, B. G., Warrener, R. M., Burgess, A. J. and Beamish, H. J. (2004). Defining the chemotherapeutic targets of Histone Deacetylase inhibitors. Annals New York Academy of Sciences, 1030, 627-635. doi: 10.1196/annals.1329.073

Histone deacetylase inhibitors specifically kill nonproliferating tumour cells

Burgess, Andrew, Ruefli, Astrid, Beamish, Heather, Warrener, Robyn, Saunders, Nicholas, Johnstone, Ricky and Gabrielli, Brian (2004). Histone deacetylase inhibitors specifically kill nonproliferating tumour cells. Oncogene, 23 (40), 6693-6701. doi: 10.1038/sj.onc.1207893

The EBNA- 3 gene family proteins disrupt the G2/M checkpoint

Krauer, Kenia G., Burgess, Andrew, Buck, Marion, Flanagan, James, Sculley, Tom B. and Gabrielli, Brian (2004). The EBNA- 3 gene family proteins disrupt the G2/M checkpoint. Oncogene, 23 (7), 1342-1353. doi: 10.1038/sj.onc.1207253

14-3-3 acts as an intramolecular bridge to regulate cdc25B localization and activity

Giles, N., Forrest, A. and Gabrielli, B. (2003). 14-3-3 acts as an intramolecular bridge to regulate cdc25B localization and activity. Journal of Biological Chemistry, 278 (31), 28580-28587. doi: 10.1074/jbc.M304027200

APC mutation and tumour budding in colorectal cancer

Jass, JR, Barker, M, Fraser, L, Walsh, MD, Whitehall, VLJ, Gabrielli, B, Young, J and Leggett, BA (2003). APC mutation and tumour budding in colorectal cancer. Journal of Clinical Pathology, 56 (1), 69-73. doi: 10.1136/jcp.56.1.69

Mechanism of mitosis-specific activation of MEK1

Harding, A., Giles, N., Burgess, A., Hancock, J. F. and Gabrielli, B. G. (2003). Mechanism of mitosis-specific activation of MEK1. Journal of Biological Chemistry, 278 (19), 16747-16754. doi: 10.1074/jbc.M301015200

Tumor cell-specific cytotoxicity by targeting cell cycle checkpoints

Warrener, R, Beamish, H, Burgess, A, Waterhouse, NJ, Giles, N, Fairlie, DP and Gabrielli, B (2003). Tumor cell-specific cytotoxicity by targeting cell cycle checkpoints. Faseb Journal, 17 (9), 1550-1570. doi: 10.1096/fj.02-1003fje

Identifying molecular targets mediating the anticancer activity of histone deacetylase inhibitors: A work in progress

Gabrielli, B. G., Johnstone, R. W. and Saunders, N. A. (2002). Identifying molecular targets mediating the anticancer activity of histone deacetylase inhibitors: A work in progress. Current Cancer Drug Targets, 2 (4), 337-353. doi: 10.2174/1568009023333818

A histone deacetylase inhibitor, azelaic bishydroxamic acid, shows cytotoxicity on Epstein-Barr virus-transformed B-cell lines - A potential therapy for posttransplant lymphoproliferative disease

Sculley, T. B., Buck, M., Gabrielli, B., Parsons, P. G. and Krauer, K. G. (2002). A histone deacetylase inhibitor, azelaic bishydroxamic acid, shows cytotoxicity on Epstein-Barr virus-transformed B-cell lines - A potential therapy for posttransplant lymphoproliferative disease. Transplantation, 73 (2), 271-279. doi: 10.1097/00007890-200201270-00021

Introduction: Molecular and biomechanical basis of osteoarthritis

Pavey, Sandra, Russell, Terry and Gabrielli, Brian (2002). Introduction: Molecular and biomechanical basis of osteoarthritis. Cellular and Molecular Life Sciences, 59 (1), 3-4. doi: 10.1007/s00018-002-8399-5

Loss of p16 expression is associated with histological features of melanoma invasion

Pavey, S. J., Cummings, M. C., Whiteman, D. C., Castellano, M., Walsh, M. D., Gabrielli, B. G., Green, A. and Hayward, N. K. (2002). Loss of p16 expression is associated with histological features of melanoma invasion. Melanoma Research, 12 (6), 539-547. doi: 10.1097/01.cmr.0000043154.28051.9f

Tumor-selective toxicity of histone deacetylase inhibitors is due to their targeting cell cycle checkpoint points

Gabrielli, B, Warrener, R, Beamish, H, Burgess, A and Waterhouse, N (2002). Tumor-selective toxicity of histone deacetylase inhibitors is due to their targeting cell cycle checkpoint points. European Journal of Cancer, 38, S95-S95.

alpha-melanocyte stimulating hormone potentiates p16/CDKN2A expression in human skin after ultraviolet irradiation

Pavey, S. and Gabrielli, B. (2002). alpha-melanocyte stimulating hormone potentiates p16/CDKN2A expression in human skin after ultraviolet irradiation. Cancer Research, 62 (3), 875-880.

G2 phase cell cycle arrest in human skin following UV irradiation

Pavey, Sandra, Russell, Terry and Gabrielli, Brian (2001). G2 phase cell cycle arrest in human skin following UV irradiation. Oncogene, 20 (43), 6103-6110. doi: 10.1038/sj.onc.1204707

Cdc25B activity is regulated by 14-3-3

Forrest, A. and Gabrielli, B. (2001). Cdc25B activity is regulated by 14-3-3. Oncogene, 20 (32), 4393-4401. doi: 10.1038/sj.onc.1204574

Cdc25-dependent activation of cyclin A/cdk2 is blocked in G2 phase arrested cells independently of ATM/ATR

Goldstone, S., Pavey, S., Forrest, A., Sinnamon, J. and Gabrielli, B. (2001). Cdc25-dependent activation of cyclin A/cdk2 is blocked in G2 phase arrested cells independently of ATM/ATR. Oncogene, 20 (8), 921-932. doi: 10.1038/sj.onc.1204177

Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts

Brinkmann, Hannah, Dahler, Alison L., Popa, Claudia, Serewko, Magdalena M., Parsons, Peter G., Gabrielli, Brian G., Burgess, Andrew J. and Saunders, Nicholas A. (2001). Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts. Journal of Biological Chemistry, 276 (25), 22491-22499. doi: 10.1074/jbc.M100206200

Up-regulation of p21(WAF1)/(CIP1) by histone deacetylase inhibitors reduces their cytotoxicity

Burgess, A. J., Pavey, S., Warrener, R., Hunter, L. J. K., Piva, T. J., Musgrove, E. A., Saunders, N., Parsons, P. G. and Gabrielli, B. G. (2001). Up-regulation of p21(WAF1)/(CIP1) by histone deacetylase inhibitors reduces their cytotoxicity. Molecular Pharmacology, 60 (4), 828-837.

Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells

Qiu, Ling, Burgess, Andrew, Fairlie, David P., Leonard, Helen, Parsons, Peter G. and Gabrielli, Brian G. (2000). Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells. Molecular Biology of the Cell, 11 (6), 2069-2083. doi: 10.1091/mbc.11.6.2069

Regulation of CDC25B phosphatases subcellular localization

Davezac, N, Baldin, V, Gabrielli, B, Forrest, A, Theis-Febvre, N, Yashida, M and Ducommun, B (2000). Regulation of CDC25B phosphatases subcellular localization. Oncogene, 19 (18), 2179-2185. doi: 10.1038/sj.onc.1203545

Centrosomal and cytoplasmic Cdc2/Cyclin B1 activation precedes nuclear mitotic events

De Souza, C. P. C., Ellem, K. A. O. and Gabrielli, B. G. (2000). Centrosomal and cytoplasmic Cdc2/Cyclin B1 activation precedes nuclear mitotic events. Experimental Cell Research, 257 (1), 11-21. doi: 10.1006/excr.2000.4872

Multiple splicing variants of cdc25B regulate G2/M progression

Forrest, A. R. R., McCormack, A. K., DeSouza, C. P. C., Sinnamon, J. M., Tonks, I. D., Hayward, N. K., Ellem, K. A. O. and Gabrielli, B. G. (1999). Multiple splicing variants of cdc25B regulate G2/M progression. Biochemical and Biophysical Research Communications, 260 (2), 510-515. doi: 10.1006/bbrc.1999.0870

A cyclin D-Cdk4 activity required for G2 phase cell cycle progression is inhibited in ultraviolet radiation-induced G2 phase delay

Gabrielli, B., Sarcevic, B., Sinnamon, J. M., Walker, G. J., Castellano, M., Wang, X. Q. and Ellem, K. (1999). A cyclin D-Cdk4 activity required for G2 phase cell cycle progression is inhibited in ultraviolet radiation-induced G2 phase delay. The Journal of Biological Chemistry, 274 (20), 13961-13969. doi: 10.1074/jbc.274.20.13961

Functional reassessment of p16 variants using a transfection-based assay

Walker, GJ, Gabrielli, BG, Castellano, M and Hayward, NK (1999). Functional reassessment of p16 variants using a transfection-based assay. International Journal of Cancer, 82 (2), 305-312. doi: 10.1002/(SICI)1097-0215(19990719)82:2<305::AID-IJC24>3.0.CO;2-Z

Ultraviolet radiation induces p16CDKN2A expression in human skin

Pavey, S. J., Conroy, S., Russell, T. and Gabrielli, B. (1999). Ultraviolet radiation induces p16CDKN2A expression in human skin. Cancer Research, 59 (17), 4185-4189.

Involvement of p16(CDKN2A) in cell cycle delays after low dose UV irradiation

Milligan, A, Gabrielli, BG, Clark, JM, Hayward, NK and Ellem, KAO (1998). Involvement of p16(CDKN2A) in cell cycle delays after low dose UV irradiation. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 422 (1), 43-53. doi: 10.1016/S0027-5107(98)00174-2

ATM associates with and phosphorylates p53: Mapping the region of interaction

Khanna K.K., Keating K.E., Kozlov S., Scott S., Gatei M., Hobson K., Taya Y., Gabrielli B., Chan D., Lees-Miller S.P. and Lavin M.F. (1998). ATM associates with and phosphorylates p53: Mapping the region of interaction. Nature Genetics, 20 (4), 398-400. doi: 10.1038/3882

Production of a soluble cyclin B/cdc2 substrate for cdc25 phosphatase

Clark J.M. and Gabrielli B.G. (1997). Production of a soluble cyclin B/cdc2 substrate for cdc25 phosphatase. Analytical Biochemistry, 254 (2), 231-235. doi: 10.1006/abio.1997.2412

Hyperphosphorylation of the N-terminal domain of cdc25 regulates activity toward cyclin B1/cdc2 but not cyclin A/cdk2

Gabrielli B.G., Clark J.M., McCormack A.K. and Ellem K.A.O. (1997). Hyperphosphorylation of the N-terminal domain of cdc25 regulates activity toward cyclin B1/cdc2 but not cyclin A/cdk2. Journal of Biological Chemistry, 272 (45), 28607-28614. doi: 10.1074/jbc.272.45.28607

CDKN2A/p16 is inactivated in most melanoma cell lines

Castellano, M, Pollock, PM, Walters, MK, Sparrow, LE, Down, LM, Gabrielli, BG, Parsons, PG and Hayward, NK (1997). CDKN2A/p16 is inactivated in most melanoma cell lines. Cancer Research, 57 (21), 4868-4875.

Reduced expression of retinoblastoma gene product (pRB) and high expression of p53 are associated with poor prognosis in ovarian cancer

Dong, Y, Walsh, MD, McGuckin, MA, Cummings, MC, Gabrielli, BG, Wright, GR, Hurst, T, Khoo, SK and Parsons, PG (1997). Reduced expression of retinoblastoma gene product (pRB) and high expression of p53 are associated with poor prognosis in ovarian cancer. International Journal of Cancer, 74 (4), 407-415. doi: 10.1002/(SICI)1097-0215(19970822)74:4<407::AID-IJC8>3.0.CO;2-Z

Ultraviolet light-induced G2 phase cell cycle checkpoint blocks cdc25-dependent progression into mitosis

Gabrielli, BG, Clark, JM, McCormack, AK and Ellem, KAO (1997). Ultraviolet light-induced G2 phase cell cycle checkpoint blocks cdc25-dependent progression into mitosis. Oncogene, 15 (7), 749-758. doi: 10.1038/sj.onc.1201254

Restoration of CDKN2A into melanoma cells induces morphologic changes and reduction in growth rate but not anchorage-independent growth reversal

Castellano, M, Gabrielli, BG, Hussussian, CJ, Dracopoli, NC and Hayward, NK (1997). Restoration of CDKN2A into melanoma cells induces morphologic changes and reduction in growth rate but not anchorage-independent growth reversal. Journal of Investigative Dermatology, 109 (1), 61-68. doi: 10.1111/1523-1747.ep12276538

Increased expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product p16(INK4A) in ovarian cancer is associated with progression and unfavourable prognosis

Dong, Y, Walsh, MD, McGuckin, MA, Gabrielli, BG, Cummings, MC, Wright, RC, Hurst, T, Khoo, SK and Parsons, PG (1997). Increased expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product p16(INK4A) in ovarian cancer is associated with progression and unfavourable prognosis. International Journal of Cancer, 74 (1), 57-63. doi: 10.1002/(SICI)1097-0215(19970220)74:1<57::AID-IJC10>3.0.CO;2-F

Accumulation of p16(CDKN2A) in response to ultraviolet irradiation correlates with a late S-G(2)-phase cell cycle delay

Wang, XQ, Gabrielli, BG, Milligan, A, Dickinson, JL, Antalis, TM and Ellem, KAO (1996). Accumulation of p16(CDKN2A) in response to ultraviolet irradiation correlates with a late S-G(2)-phase cell cycle delay. Cancer Research, 56 (11), 2510-2514.

Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells

Gabrielli, BG, DeSouza, CPC, Tonks, ID, Clark, JM, Hayward, NK and Ellem, KAO (1996). Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells. Journal of Cell Science, 109 (5), 1081-1093.

Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells

De Souza, C. P.C., Gabrielli, B. C., Clark, J. M. and Ellem, K. A.O. (1996). Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells. Biochemical Society Transactions, 24 (4)

Purification of a serine kinase that associates with and phosphorylates human Cdc25C on serine 216

Ogg, Scott, Gabrielli, Brian and Piwnica-Worms, Helen (1994). Purification of a serine kinase that associates with and phosphorylates human Cdc25C on serine 216. Journal of Biological Chemistry, 269 (48), 30461-30469.

Cell cycle regulation of the p34cdc2 inhibitory kinases

Atherton-Fessler, Sue, Liu, Feng, Gabrielli, Brian, Lee, Margaret S., Peng, Cheng-Yuan and Piwnica-Worms, Helen (1994). Cell cycle regulation of the p34cdc2 inhibitory kinases. Molecular Biology of the Cell, 5 (9), 989-1001. doi: 10.1091/mbc.5.9.989

A cardiolipin-activated protein kinase from rat liver structurally distinct from the protein kinases C

Morrice, Nicholas A., Gabrielli, Brian, Kemp, Bruce E. and Wettenhall, Richard E. H. (1994). A cardiolipin-activated protein kinase from rat liver structurally distinct from the protein kinases C. Journal of Biological Chemistry, 269 (31), 20040-20046.

Requirement for Cdk2 in Cytostatic Factor Mediated Metaphase-Ii Arrest

Gabrielli, BG, Roy, LM and Maller, JL (1993). Requirement for Cdk2 in Cytostatic Factor Mediated Metaphase-Ii Arrest. Science, 259 (5102), 1766-1769. doi: 10.1126/science.8456304

Cdc25 regulates the phosphorylation and activity of the Xenopus cdk2 protein kinase complex

Gabrielli, Brian G., Lee, Margaret S., Walker, Duncan H., Piwnicaworms, Helen and Maller, James L. (1992). Cdc25 regulates the phosphorylation and activity of the Xenopus cdk2 protein kinase complex. Journal of Biological Chemistry, 267 (25), 18040-18046.

A cdc2-related kinase oscillates in the cell cycle independently of cyclins G2/M and cdc2

Gabrielli, Brian G., Roy, Linda M., Gautier, Jean, Philippe, Michel and Maller, James L. (1992). A cdc2-related kinase oscillates in the cell cycle independently of cyclins G2/M and cdc2. Journal of Biological Chemistry, 267 (3), 1969-1975.

Activation of p34cdc2 kinase by cyclin A

Roy, L. M., Swenson, K. I., Walker, D. H., Gabrielli, B. G., Li, R. S., Piwnicaworms, H. and Maller, J. L. (1991). Activation of p34cdc2 kinase by cyclin A. Journal of Cell Biology, 113 (3), 507-514. doi: 10.1083/jcb.113.3.507

Determinants of multi-site phosphorylation of peptide analogues of ribosomal protein S6 by novel protease-activated protein kinases

Wettenhall, R. E., Gabrielli, B., Morrice, N., Bozinova, L., Kemp, B. E. and Stapleton, D. (1991). Determinants of multi-site phosphorylation of peptide analogues of ribosomal protein S6 by novel protease-activated protein kinases. Peptide research, 4 (3), 158-170.

Phosphorylation of Ribosomal Protein-S6 and a Peptide Analog of S6 by a Protease-Activated Kinase Isolated From Rat-Liver

Gabrielli, B, Wettenhall, Reh, Kemp, BE, Quinn, M and Bizonova, L (1984). Phosphorylation of Ribosomal Protein-S6 and a Peptide Analog of S6 by a Protease-Activated Kinase Isolated From Rat-Liver. Febs Letters, 175 (2), 219-226. doi: 10.1016/0014-5793(84)80740-1

Inhibition of Aurora B kinase activity triggers senescence that can be bypassed by blocking p53 and RB function, promoting replication stress

Andrews, Ariel, Kumar, Ramyashree Prasanna, Nazareth, Deborah, Ehmann, Anna, Hooper, John, McMillan, Nigel and Gabrielli, Brian (2019). Inhibition of Aurora B kinase activity triggers senescence that can be bypassed by blocking p53 and RB function, promoting replication stress. AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, MA USA, 26-30 October 2019. Philadelphia, PA USA: American Association for Cancer Research. doi: 10.1158/1535-7163.TARG-19-A060

Bortezomib-induced immunogenic cell death enhances immune response in melanoma

Daignault, S. M., Ju, R., Spoerri, L., Stehbens, S. J., Hill, D. S., Gabrielli, B., Dolcetti, R. and Haass, N. K. (2019). Bortezomib-induced immunogenic cell death enhances immune response in melanoma. Society for Investigative Dermatology (SID) Meeting, Chicago, IL United States, 8-11 May 2019. London, United Kingdom: Nature Publishing Group. doi: 10.1016/j.jid.2019.03.907

Subclinical doses and choice of replication stress inducer in combination with CHK1 inhibitors for optimal tumor control and immune responses in vitro and in vivo

Oo, Zay Yar, Proctor, Martina, Stevenson, Alex, Nazareth, Deborah, Larsen, Jill, Haass, Nikolas and Gabrielli, Brian G. (2019). Subclinical doses and choice of replication stress inducer in combination with CHK1 inhibitors for optimal tumor control and immune responses in vitro and in vivo. AACR Annual Meeting on Bioinformatics, Convergence Science, and Systems Biology, Atlanta Ga, Mar 29-Apr 03, 2019. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.AM2019-1236

Distinct epigenetic remodelling defines early stress-induced drug tolerance in melanoma

Emran, A., Marzese, D. M., Menon, D. R., Stark, M., Torrano, J., Hammerlindl, H., Zhang, G., Brafford, P., Hammerlindl, S., Gupta, D., Mills, G. B., Lu, Y., Flaherty, K., Sturm, R., Hoon, D. S. B., Gabrielli, B., Herlyn, M. and Schaider, H. (2018). Distinct epigenetic remodelling defines early stress-induced drug tolerance in melanoma. Australasian College of Dermatologists, 51st Annual Scientific Meeting, Gold Coast, QLD, Australia , 19–22 May 2018. Richmond, VIC, Australia: Wiley-Blackwell Publishing. doi: 10.1111/ajd.16_12815

Overexpression of the cell cycle regulator Emi1 promotes chromosome instability and tumorigenesis

Duijf, Pascal H. G., Vaidyanathan, Srividya, Cato, Kathleen, Thangavelu, Pulari U., Lin, Cheng-Yu, Tang, Lu, Pavey, Sandra, Haass, Nikolas K. and Gabrielli, Brian G. (2018). Overexpression of the cell cycle regulator Emi1 promotes chromosome instability and tumorigenesis. 76th Annual Meeting of the Japanese Cancer Association, Yokohama, Japan, 28-30 September 2017. Tokyo, Japan: Wiley Japan. doi: 10.1111/cas.13499

Targeting cell cycle phase-specific drug sensitivity for melanoma therapy

Daignault, S. M., Hill, D. S., Spoerri, L., Stehbens, S., Weninger, W., Gabrielli, B., Dolcetti, R. and Haass, N. K. (2018). Targeting cell cycle phase-specific drug sensitivity for melanoma therapy. 45th Annual Meeting of the Arbeitsgemeinscha-Dermatologische-Forschung (ADF), Zurich, Switzerland, 7-10 March 2018. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.

Cell cycle-tailored targeting of metastatic melanoma: challenges and opportunities

Haass, N., Spoerri, L., Tonnessen, C. A., Beaumont, K. A., Hill, D. S., Daignault, S. M., Gabrielli, B. and Weninger, W. (2017). Cell cycle-tailored targeting of metastatic melanoma: challenges and opportunities. Australasian College of Dermatologists 50th Annual Scientific Meeting, International Convention Centre, Sydney, NSW Australia, 6-9 May 2017. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.20_12652

Cell cycle phase-specific drug resistance as an escape mechanism of melanoma cells

Beaumont, K., Hill, D., Daignault, S., Sharp, D., Gabrielli, B., Weninger, W. and Haass, N. (2016). Cell cycle phase-specific drug resistance as an escape mechanism of melanoma cells. Annual Meeting of the Society-for-Investigative-Dermatology (SID), Scottsdale, AZ, United States, 11-14 May 2016. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2016.02.695

Global histone modifications define early stress induced drug tolerance in cancer

Al Emran, Abdullah, Menon, Dinoop Ravindran, Soyer, Peter, Gabrielli, Brian, Sturm, Rick, Herlyn, Meenhard and Schaider, Helmut (2016). Global histone modifications define early stress induced drug tolerance in cancer. American-Association-for-Cancer-Research (AACR) Special Conference on Chromatin and Epigenetics in Cancer, Atlanta, GA, United States, 24-27 September 2015. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.CHROMEPI15-B34

Inhibition of Aurora Kinases is curative for HPV-driven tumours

McMillan, N., Fallaha, S., Martin, D., Leggatt, G. and Gabrielli, B. (2016). Inhibition of Aurora Kinases is curative for HPV-driven tumours. 16th Biennial Meeting of the International Gynecologic Cancer Society, Lisbon, Portugal, 28-31 October 2016. London, United Kingdom: Lippincott Williams & Wilkins. doi: 10.1097/01.IGC.0000503327.50238.5c

Abstract 945: synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer

Gabrielli, Brian G., Bokhari, Fawzi, Ranall, Max, Oo, Zay Yar, Stevenson, Alex, Wang, Weili, McKee, Sara, Leggatt, Graham, Leo, Paul, Gonda, Thomas J. and McMillan, Nigel A. J. (2015). Abstract 945: synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer. 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Philadelphia, PA United States, 18-22 April 2015. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2015-945

Melanoma cells in G1 phase escape proteasome inhibitor cytotoxicity

Hill, D. S., Beaumont, K. A., Daignault, S. M., Anfosso, A., Sharp, D. M., Gabrielli, B., Lovat, P. E., Weninger, W. and Haass, N. K. (2015). Melanoma cells in G1 phase escape proteasome inhibitor cytotoxicity. 42nd Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), Ulm, Germany, Mar 05-07, 2015. Chichester, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/exd.12623

Synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer

Gabrielli, B., Bokhari, F., Ranall, M., Stevenson, A., Murell, M., Kelly, M., McKee, S., Leggatt, G., Gonda, T. and McMillan, N. (2014). Synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer. 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Barcelona Spain, 18-21 November 2014. Abingdon, Oxford, United Kingdom: Elsevier. doi: 10.1016/S0959-8049(14)70420-4

Chk1 inhibitor targets replicative stress in melanomas

Gabrielli, Brian G., Brooks, Kelly, Edwards, Brooke, Chen, James and Pavey, Sandra (2013). Chk1 inhibitor targets replicative stress in melanomas. 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington Dc, Apr 06-10, 2013. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.AM2013-3425

A Genome-wide Human ORF Gain-of-function Screen to Identify Genes that can Bypass p16INK4a-mediated Cellular Senescence

Lee, W. J., Skalamera, D., Dahmer, M., Shakhbazov, K., Purdon, A., Wilson, B., Ranall, M, Pinder, A., Pavey, S., Gonda, T. and Gabrielli, B. (2012). A Genome-wide Human ORF Gain-of-function Screen to Identify Genes that can Bypass p16INK4a-mediated Cellular Senescence. 6th Australian High Content Screening Group Meeting, Melbourne, Australia, 13th July 2012.

Chk1 inhibitor targets replicative stress in melanomas

Gabrielli, B., Brooks, K., Oakes, V., Edwards, B., Chen, J. and Mukhopadhyay, P. (2012). Chk1 inhibitor targets replicative stress in melanomas. 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin Ireland, 6-9 November 2012. Oxford, United Kingdom: Pergamon. doi: 10.1158/1538-7445.AM2013-3425

Abstract 4197: A DNA damage checkpoint response to unrepaired ultraviolet radiation-induced lesions which is defective in melanoma

Wigan, Matthew, Pavey, Sandra, Brooks, Kelly, Giles, Nichole, Burgess, Andrew, Sturm, Rick and Gabrielli, Brian (2011). Abstract 4197: A DNA damage checkpoint response to unrepaired ultraviolet radiation-induced lesions which is defective in melanoma. AACR 102nd Annual Meeting 2011, Orlando, FL United States, 2‐6 April 2011. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2011-4197

A functional genomics approach to identify genes and pathways that can bypass p16INK4a-mediated cellular senescence

Lee, W. J., Skalamera, D., Dahmer, M., Shakhbazov, K., Ranall, M., Purdon, A., Wilson, B., Pinder, A., Pavey, S., Gonda, T. and Gabrielli, B. (2011). A functional genomics approach to identify genes and pathways that can bypass p16INK4a-mediated cellular senescence. 14th Annual Australian Cell Cycle Workshop, Noosa, Australia, 24 October 2011.

A high-coverage and high-content human ORF overexpression screen to identify pathways that can bypass p16INK4a-mediated cellular senescence

Lee, W. J., Skalamera, D. and Gabrielli, B. (2011). A high-coverage and high-content human ORF overexpression screen to identify pathways that can bypass p16INK4a-mediated cellular senescence. 5th Australian High Content Screening Group Meeting, Melbourme, Australia, 15 July 2011.

Fatty acids induce hepatocyte senescence in vitro: implications for pathogenesis in non-alcoholic steatohepatitis

Skoien, R., Powell, E. E., Melino, M., Clouston, A. D., Gabrielli, B. G. and Jonsson, J. R. (2010). Fatty acids induce hepatocyte senescence in vitro: implications for pathogenesis in non-alcoholic steatohepatitis. Australian Gastroenterology Week 2010, Gold Coast, QLD, Australia, 20-23 October 2010. Richmond, VIC, Australia: Wiley-Blackwell Publishing. doi: 10.1111/j.1440-1746.2010.06450.x

Suberythemal UV G2 phase checkpoint in response to post replication repair is defective in a majority of melanoma cell lines

Wigan, M., Giles, N., Pavey, S. and Gabrielli, B. (2009). Suberythemal UV G2 phase checkpoint in response to post replication repair is defective in a majority of melanoma cell lines. 5th Annual Scientific Meeting of the Australasian Society for Dermatology Research, Sydney, Australia, 21-22 May 2008. United Kingdom: Nature Publishing Group. doi: 10.1038/jid.2009.333

UVR induced ERK signaling pathway regulates p16 expression in skin

Giles, N., Pavey, S. and Gabrielli, B (2009). UVR induced ERK signaling pathway regulates p16 expression in skin. 5th Annual Scientific Meeting of the Australasian-Society-for-Dermatology-Research, Sydney, Australia, 21-22 May 2008. United Kingdom: Nature Publishing Group. doi: 10.1038/jid.2009.333