Associate Professor Alexander Khromykh

Associate Professor

School of Chemistry and Molecular Biosciences
Faculty of Science

Overview

Alexander Khromykh received his BSc degree from the Tomsk State University, Russia, and his PhD degree in Molecular Virology from the State Centre for Virology and Biotechnology, NPO Vector”, Russia. He worked as Postdoctoral Fellow at the University of Ottawa in Canada. He then joined Sir Albert Sakzewski Virus Research Centre in Brisbane in 1992 and became a laboratory Head in 2001. He moved his laboratory to St Luica campus in 2005 to take an appointment with the School of Chemistry and Molecular Biosciences (SCMB). He was the founding Director of the SCMB’s Centre for Infectious Disease Research and is currently the Deputy Director of the Australian Infectious Diseases Research Centre.

Research Interests

  • Molecular pathogenesis of West Nile virus
  • Viral evasion of host innate immune response
  • Viral and host small regulatory RNAs
  • Flavivirus non-coding subgenomic RNA
  • Pseudo-infectious flavivirus DNA vaccines
  • Replicon-based vaccine and cancer therapy vectors

Research Impacts

The main areas of research of the group are molecular virology, viral pathogenesis, and virus-host interactions. The viruses studied in the group are encephalitic flaviviruses, primarily West Nile virus, and alphavirus Chikungunya. The goal of the research is to determine the mechanisms by which these viruses cause disease in the hosts and to identify viral and host factors determining the outcome of infection. The group uses a range of classical and more modern approaches including molecular manipulations with viral infectious cDNA clones and replicons, transient and stable expression of viral proteins and noncoding RNAs, viral replication and virulence assays, microarrays, mass spectrometry, next generation sequencing analysis, siRNA knockdowns, and knockout cells and mice. Together, these approaches allow the group to perform detailed analysis of the effects of changes in the viral and host genomes that are likely to have a profound impact on virus replication and pathogenesis

Qualifications

  • Bachelor of Science, Tomsk State University
  • Doctor of Philosophy, The Institute for Molecular Virology

Publications

  • Slonchak, Andrii, Hugo, Leon E., Freney, Morgan, Amarilla, Alberto A, Hall-Mendelin, Sonja, Yan, Kexin, Torres, Francisco, Setoh, Yin Xiang, Peng, Nias, Chaggar, Harman K, Hurk, Andrew Van Den, Wolvetang, Ernst, Suhrbier, Andreas, Devine, Gregor J. and Khromykh, Alexander A (2020). Zika Virus sfRNA Plays an Essential Role in the Infection of Insects and Mammals. Proceedings, 50 (1) doi:10.3390/proceedings2020050112

  • Harrison, Jessica J., Hobson-Peters, Jody, Colmant, Agathe M. G., Koh, Joanna, Newton, Natalee D., Warrilow, David, Bielefeldt-Ohmann, Helle, Piyasena, Thisun B. H., O’Brien, Caitlin A., Vet, Laura J., Paramitha, Devina, Potter, James R., Davis, Steven S., Johansen, Cheryl A., Setoh, Yin Xiang, Khromykh, Alexander A. and Hall, Roy A. (2020). Antigenic characterization of new lineage II insect-specific flaviviruses in Australian mosquitoes and identification of host restriction factors. mSphere, 5 (3) 1-19. doi:10.1128/msphere.00095-20

  • Slonchak, Andrii, Hugo, Leon E., Freney, Morgan E., Hall-Mendelin, Sonja, Amarilla, Alberto A., Torres, Francisco J., Setoh, Yin Xiang, Peng, Nias Y. G., Sng, Julian D. J., Hall, Roy A., van den Hurk, Andrew F., Devine, Gregor J. and Khromykh, Alexander A. (2020). Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes. Nature Communications, 11 (1) 2205, doi:10.1038/s41467-020-16086-y

View all Publications

Publications

Book Chapter

  • Roby, Justin A., Funk, Anneke and Khromykh, Alexander A. (2012). Flavivirus replication and assembly. Molecular virology and control of flaviviruses. (pp. 21-49) edited by Pei-Yong Shi.Norfolk, United Kingdom: Caister Academic Press.

  • Roby, Justin A., Hall, Roy A. and Khromykh, Alexander A. (2011). Nucleic acid-based infectious and pseudoinfectious flavivirus vaccines. Replicating vaccines : A new generation. (pp. 299-320) edited by Philip R. Dormitzer, Christian W. Mandl and Rino Rappuoli.Basel, Switzerland: Springer. doi:10.1007/978-3-0346-0277-8_13

  • Khromykh, Alexander A., Chang, David C. and Hall, Roy A. (2009). Vaccine development against West Nile Virus. West Nile Encephalitis Virus Infection: Viral Pathogenesis and the Host Immune Response. (pp. 427-451) edited by Diamond, Michael S..New York: Springer Science + Business Media.

  • Westaway, E. G., Mackenzie, J. M. and Khromykh, A. A. (2003). Kunjin RNA replication and applications of Kunjin replicons. The Flaviviruses: Structure, replication and evolution. (pp. 100-140) edited by Thomas J. Chambers, Thomas P. Monath, Karl Maramorosch, Aaron J. Shatkin and Frederick A. Murphy.San Diego: Academic Press Inc. doi:10.1016/S0065-3527(03)59004-2

  • Westaway, E. G., Mackenzie, J. M. and Khromykh, A. A. (2002). Replication and gene function in Kunjin virus. Japanese Encephalitis and West Nile Viruses. (pp. 323-352) edited by J. S. Mackenzie, A. D. T. Barrett and V. Deubel.Berlin: Springer.

Journal Article

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

Completed Supervision