Professor Anders Cervin has a longstanding interest in sino-nasal disorders, endoscopic sinus surgery as well as endoscopic anterior skull base surgery. His research interests includes mucociliary function in the upper airways, the role of Nitric Oxide in chronic sinusitis, the use of macrolide antibiotics as a immune modulator in chronic sinusitis and health economic perspectives on sino-nasal disease. Recent research addresses the role of probiotics in airway infection and inflammation. He has authored several book chapters and over 50 peer reviewed articles.
Treatment of Chronic Sinusits and Middle Ear Infections (Otitis Media) with Probiotics
Chronic rhinosinusitis (CRS) affects 8-10% of the western population, mainly middle-aged adults in the prime of their working life, and causes a significant reduction in quality of life. Although unproven the mainstay of treatment have been antibiotics, unfortunately with limited long-term success. Another difficult to treat infection, is recurrent middle ear infection, especially prevalent in Indigenous children. Our research group have focused on identifying friendly bacteria in the upper airways of indigenous children as well as adults with chronic sinusitis. The approach is unique as we are targeting what is maintaining health rather than what causes disease. Thus we have identified a number of bacterial strains that have the capability of interfering with the pathogenic bacteria commonn in chronic sinusitis as well as in recurrent ear disease. We are now in the process of setting up clinical trials to test the effect of friendly bacteria on bacterial colonisation in the ears and sinuses. Should it be successful, it would be a paradigm shift in the way we treat upper airway infections and reduce the need for antibiotics and help to reduce antibiotic resistance in the community.
Journal Article: Lactobacillus rhamnosus dampens cytokine and chemokine secretion from primary human nasal epithelial cells infected with rhinovirus
Yarlagadda, Tejasri, Zhu, Yanshan, Snape, Natale, Carey, Alison, Bryan, Emily, Maresco-Pennisi, Diane, Coleman, Andrea, Cervin, Anders and Spann, Kirsten (2024). Lactobacillus rhamnosus dampens cytokine and chemokine secretion from primary human nasal epithelial cells infected with rhinovirus. Journal of Applied Microbiology, 135 (2) lxae018. doi: 10.1093/jambio/lxae018
Journal Article: Impact of long-acting implantable LYR-210 corticosteroid matrices on quality of life of patients with chronic rhinosinusitis in the LANTERN study
Rimmer, Joanne, Cervin, Anders, Wrobel, Agnieszka, Gartung, Allison, Brayton, Lindsay, Shao, James and Belanger, Vineeta (2023). Impact of long-acting implantable LYR-210 corticosteroid matrices on quality of life of patients with chronic rhinosinusitis in the LANTERN study. International Forum of Allergy and Rhinology, 13 (9), 1821-1824. doi: 10.1002/alr.23139
Journal Article: Upper airway microbiome transplantation for patients with chronic rhinosinusitis
Mårtensson, Anders, Cervin-Hoberg, Charlotte, Huygens, Flavia, Lindstedt, Malin, Sakellariou, Christina, Greiff, Lennart and Cervin, Anders (2023). Upper airway microbiome transplantation for patients with chronic rhinosinusitis. International Forum of Allergy and Rhinology, 13 (6), 979-988. doi: 10.1002/alr.23122
(2021–2025) NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
Development of Phage Therapy to Combat Chronic Otitis Media in Indigenous Children
(2020–2024) NHMRC IDEAS Grants
(2017–2027) Garnett Passe/Rodney Williams Memorial Foundation
Testing a sinonasal microbiome transplant as a therapy for Chronic Rhinosinusitis by randomised controlled trial
Master Philosophy
(2021) Doctor Philosophy
Simultaneous comparison of novel and traditional methods for the diagnosis of Laryngopharyngeal Reflux: A prospective cohort study
Doctor Philosophy
Probiotic treatment of Chronic Rhinosinusits
The overall aim of the project is to improve quality of life in patients suffering from Chronic RhinoSinusitis (CRS). Specifically by manipulating mucosal immunology and reducing the load of microbial pathogens in CRS by topical administration of probiotic bacterial strains. You will work in a stimulating environment in close relationship with patients, ENT surgeons, microbiologists and other researchers. The project have international collaborators in the Netherlands and Sweden. The project is truly translational you will acquire skills in clinical trials (GCP), as well as gaining laboratory experience in microbiology and cytokine analysis.
Yarlagadda, Tejasri, Zhu, Yanshan, Snape, Natale, Carey, Alison, Bryan, Emily, Maresco-Pennisi, Diane, Coleman, Andrea, Cervin, Anders and Spann, Kirsten (2024). Lactobacillus rhamnosus dampens cytokine and chemokine secretion from primary human nasal epithelial cells infected with rhinovirus. Journal of Applied Microbiology, 135 (2) lxae018. doi: 10.1093/jambio/lxae018
Rimmer, Joanne, Cervin, Anders, Wrobel, Agnieszka, Gartung, Allison, Brayton, Lindsay, Shao, James and Belanger, Vineeta (2023). Impact of long-acting implantable LYR-210 corticosteroid matrices on quality of life of patients with chronic rhinosinusitis in the LANTERN study. International Forum of Allergy and Rhinology, 13 (9), 1821-1824. doi: 10.1002/alr.23139
Upper airway microbiome transplantation for patients with chronic rhinosinusitis
Mårtensson, Anders, Cervin-Hoberg, Charlotte, Huygens, Flavia, Lindstedt, Malin, Sakellariou, Christina, Greiff, Lennart and Cervin, Anders (2023). Upper airway microbiome transplantation for patients with chronic rhinosinusitis. International Forum of Allergy and Rhinology, 13 (6), 979-988. doi: 10.1002/alr.23122
The EUFOREA pocket guide for chronic rhinosinusitis
Hellings, P. W., Fokkens, W. J., Orlandi, R., Adriaensen, G. F., Alobid, I., Baroody, F. M., Bjermer, L., Senior, B. A., Cervin, A., Cohen, N. A., Constantinidis, J., De Corso, E., Desrosiers, M., Diamant, Z., Douglas, R. G., Gane, S., Gevaert, P., Han, J. K., Harvey, R. J., Hopkins, C., Kern, R. C., Landis, B. N., Lee, J. T., Lee, S. E., Leunig, A., Lund, V. J., Bernal-Sprekelsen, M., Mullol, J., Philpott, C. ... Wagenmann, M. (2023). The EUFOREA pocket guide for chronic rhinosinusitis. Rhinology, 61 (1), 85-89. doi: 10.4193/Rhin22.344
Mårtensson, Anders, Nordström, Franziska U., Cervin-Hoberg, Charlotte, Lindstedt, Malin, Sakellariou, Christina, Cervin, Anders and Greiff, Lennart (2022). Nasal administration of a probiotic assemblage in allergic rhinitis: a randomised placebo-controlled crossover trial. Clinical and Experimental Allergy, 52 (6), 774-783. doi: 10.1111/cea.14098
Coleman, Andrea, Håkansson, Alexander, Grahn Håkansson, Eva, Cottrell, Kyra, Bialasiewicz, Seweryn, Zaugg, Julian and Cervin, Anders (2022). In vitro Inhibition of respiratory pathogens by lactobacillus and alpha haemolytic streptococci from Aboriginal and Torres Strait Islander children. Journal of Applied Microbiology, 132 (3), 2368-2378. doi: 10.1111/jam.15320
Cervin, Anders, Rimmer, Joanne, Wrobel, Agnieszka, Abelak, Yogen, Brayton, Lindsay and Kuang, Yina (2022). Long-acting implantable corticosteroid matrix for chronic rhinosinusitis: Results of LANTERN Phase 2 randomized controlled study. International Forum of Allergy and Rhinology, 12 (2), 147-159. doi: 10.1002/alr.22883
Coleman, Andrea, Zaugg, Julian, Wood, Amanda, Cottrell, Kyra, Håkansson, Eva Grahn, Adams, Jasmyn, Brown, Matthew, Cervin, Anders and Bialasiewicz, Seweryn (2021). Upper respiratory tract microbiome of Australian Aboriginal and Torres Strait Islander children in ear and nose health and disease. Microbiology Spectrum, 9 (2) e00367-21, e0036721. doi: 10.1128/spectrum.00367-21
A survey of Queensland medical education in otolaryngology
Yau, Stephanie, Wong, Michael and Cervin, Anders (2021). A survey of Queensland medical education in otolaryngology. Australian Journal of Otolaryngology, 4 (June) ajo2087. doi: 10.21037/ajo-20-87
COVID-19 swab-related skull base injury
Mistry, Sandeep G., Walker, Wallace, Earnshaw, James and Cervin, Anders (2021). COVID-19 swab-related skull base injury. Medical Journal of Australia, 214 (10), 457-459.e1. doi: 10.5694/mja2.51082
Radiofrequency ablation in the treatment of inferior turbinate hypertrophy
Chaudhry, Sarah, Maresco-Pennisi, Diane and Cervin, Anders (2021). Radiofrequency ablation in the treatment of inferior turbinate hypertrophy. Australian Journal of Otolaryngology, 4 (March) 5. doi: 10.21037/ajo-20-52
Coleman, Andrea, Bialasiewicz, Seweryn, Marsh, Robyn L., Grahn Håkansson, Eva, Cottrell, Kyra, Wood, Amanda, Jayasundara, Nadeesha, Ware, Robert S., Zaugg, Julian, Sidjabat, Hanna E., Adams, Jasmyn, Ferguson, Josephine, Brown, Matthew, Roos, Kristian and Cervin, Anders (2021). Upper respiratory microbiota in relation to ear and nose health among Australian Aboriginal and Torres Strait Islander children. Journal of the Pediatric Infectious Diseases Society, 10 (4), 468-476. doi: 10.1093/jpids/piaa141
Marsh, Robyn L., Aho, Celestine, Beissbarth, Jemima, Bialasiewicz, Seweryn, Binks, Michael, Cervin, Anders, Kirkham, Lea-Ann S., Lemon, Katherine P., Slack, Mary P.E. and Smith-Vaughan, Heidi C. (2020). Recent advances in understanding the natural history of the otitis media microbiome and its response to environmental pressures. International Journal of Pediatric Otorhinolaryngology, 130 (Supp. 1) 109836, 109836. doi: 10.1016/j.ijporl.2019.109836
European Position Paper on Rhinosinusitis and Nasal Polyps 2020
Fokkens, W. J., Lund, V. J., Hopkins, C., Hellings, P. W., Kern, R., Reitsma, S., Toppila-Salmi, S., Bernal-Sprekelsen, M., Mullol, J., Alobid, I., Terezinha Anselmo-Lima, W., Bachert, C., Baroody, F., von Buchwald, C., Cervin, A., Cohen, N., Constantinidis, J., De Gabory, L., Desrosiers, M., Diamant, Z., Douglas, R. G., Gevaert, P. H., Hafner, A., Harvey, R. J., Joos, G. F., Kalogjera, L., Knill, A., Kocks, J. H., Landis, B. N. ... Stjarne, P. (2020). European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology, 58 (S29), 1-464. doi: 10.4193/Rhin20.600
Bachert, Claus, Han, Joseph K, Desrosiers, Martin, Hellings, Peter W, Amin, Nikhil, Lee, Stella E, Mullol, Joaquim, Greos, Leon S, Bosso, John V, Laidlaw, Tanya M, Cervin, Anders U, Maspero, Jorge F, Hopkins, Claire, Olze, Heidi, Canonica, G Walter, Paggiaro, Pierluigi, Cho, Seong H, Fokkens, Wytske J, Fujieda, Shigeharu, Zhang, Mei, Lu, Xin, Fan, Chunpeng, Draikiwicz, Steven, Kamat, Siddhesh A, Khan, Asif, Pirozzi, Gianluca, Patel, Naimish, Graham, Neil M H, Ruddy, Marcella ... Mannent, Leda P (2019). Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials. The Lancet, 394 (10209), 1638-1650. doi: 10.1016/S0140-6736(19)31881-1
Balch, Graeme, Heal, Clare, Cervin, Anders and Gunnarsson, Ronny (2019). Oral corticosteroids for painful acute otitis externa (swimmer's ear): a triple-blind randomised controlled trial. Australian Journal of General Practice, 48 (8), 565-572. doi: 10.31128/AJGP-12-18-4795
Inflammation and endotyping in chronic rhinosinusitis — a paradigm shift
Ahern, Sinead and Cervin, Anders (2019). Inflammation and endotyping in chronic rhinosinusitis — a paradigm shift. Medicina, 55 (4) 95, 95. doi: 10.3390/medicina55040095
Douglas, Richard G., Psaltis, Alkis J., Rimmer, Joanne, Kuruvilla, Tom, Cervin, Anders and Kuang, Yina (2019). Phase 1 clinical study to assess the safety of a novel drug delivery system providing long-term topical steroid therapy for chronic rhinosinusitis. International Forum of Allergy and Rhinology, 9 (4), 378-387. doi: 10.1002/alr.22288
Trends in the quality & quantity of otorhinolaryngology research in Australia: 1989-2018
Bell-Allen, Nicholas, Cervin, Anders and Vasani, Sarju (2019). Trends in the quality & quantity of otorhinolaryngology research in Australia: 1989-2018. Australian Journal of Otolaryngology, 2 (April) 12. doi: 10.21037/ajo.2019.03.02
EPOS2020: development strategy and goals for the latest European Position Paper on Rhinosinusitis
Fokkens, Wytske, Desrosiers, Martin, Harvey, Richard, Hopkins, Claire, Mullol, Joaquim, Philpott, Carl, Alobid, Isam, Anselmo-Lima, Wilma Terezinha, Bachert, Claus, Baroody, Fuad, Bernal-Sprekelsen, Manuel, von Buchwald, Christian, Cervin, Anders, Cohen, Noam, Constantinidis, Jannis, De Gabory, Ludovic, Douglas, Richard, Gevaert, Philippe, Hafner, Anita, Hellings, Peter, Joos, Guy, Kalogjera, Livije, Kern, Rob, Knill, Andrew, Kocks, Janwillem, Landis, Basile Nicolas, Limpens, Jacqueline, Lebeer, Sarah, Lourenco, Olga ... Lund, Valerie (2019). EPOS2020: development strategy and goals for the latest European Position Paper on Rhinosinusitis. Rhinology, 57 (3), 162-168. doi: 10.4193/Rhin17.253
Probiotics in the treatment of otitis media. The past, the present and the future
Coleman, Andrea and Cervin, Anders (2019). Probiotics in the treatment of otitis media. The past, the present and the future. International Journal of Pediatric Otorhinolaryngology, 116, 135-140. doi: 10.1016/j.ijporl.2018.10.023
Coleman, Andrea, Wood, Amanda, Bialasiewicz, Seweryn, Ware, Robert S., Marsh, Robyn L. and Cervin, Anders (2018). The unsolved problem of otitis media in indigenous populations: a systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media. Microbiome, 6 (1) 199, 199. doi: 10.1186/s40168-018-0577-2
Liu, Timothy, Cooper, Thomas, Earnshaw, James and Cervin, Anders (2018). Disease burden and productivity cost of chronic rhinosinusitis patients referred to a tertiary centre in Australia. Australian Journal of Otolaryngology, 1, 5-5. doi: 10.21037/ajo.2018.01.03
Long-term patient-related outcome measures of septoplasty: a systematic review
Tsang, Chi Lap Nicholas, Nguyen, Theresa , Sivesind, Torunn and Cervin, Anders (2018). Long-term patient-related outcome measures of septoplasty: a systematic review. European Archives of Oto-rhino-laryngology, 275 (5), 1-10. doi: 10.1007/s00405-018-4874-y
The potential for topical probiotic treatment of chronic rhinosinusitis, a personal perspective
Cervin, Anders U. (2018). The potential for topical probiotic treatment of chronic rhinosinusitis, a personal perspective. Frontiers in Cellular and Infection Microbiology, 7 (JAN) 530, 530. doi: 10.3389/fcimb.2017.00530
Hopkins, Claire, Hettige, Roland, Soni-Jaiswal, Archana, Lakhani, Raj, Carrie, Sean, Cervin, Anders, Douglas, Richard, Fokkens, Wytske, Harvey, Richard, Hellings, Peter, Leunig, Andreas, Lund, Valerie, Philpott, Carl, Smith, Tim, Wang, De-Yun and Rudmik, Luke (2018). CHronic rhinosinusitis outcome MEasures (CHROME) – developing a core outcome set for trials of interventions in chronic rhinosinusitis. Rhinology, 56 (1), 22-32. doi: 10.4193/Rhino17.247
Martensson, Anders, Abolhalaj, Milad, Lindstedt, Malin, Martensson, Anette, Olofsson, Tobias C., Vasquez, Alejandra, Greiff, Lennart and Cervin, Anders (2017). Clinical Efficacy of a Topical Lactic Acid Bacterial Microbiome in Chronic Rhinosinusitis: A Randomized Controlled Trial. Laryngoscope Investigative Otolaryngology, 2 (6), 410-416. doi: 10.1002/lio2.93
Tonsillectomy or tonsillotomy? A systematic review for paediatric sleep-disordered breathing
Zhang, Lai-Ying, Zhong, Laurie, David, Michael and Cervin, Anders (2017). Tonsillectomy or tonsillotomy? A systematic review for paediatric sleep-disordered breathing. International Journal of Pediatric Otorhinolaryngology, 103, 41-50. doi: 10.1016/j.ijporl.2017.10.008
The effects of nasal lavage with betamethasone cream post-endoscopic sinus surgery: Clinical trial
Dawson, Blake, Gutteridge, I., Cervin, A. and Robinson, D. (2017). The effects of nasal lavage with betamethasone cream post-endoscopic sinus surgery: Clinical trial. Journal of Laryngology and Otology, 132 (2), 143-149. doi: 10.1017/S0022215117001827
Quality of Life and Work Capacity Are Unrelated to Approach or Complications After Pituitary Surgery
Uvelius, Erik, Castelo, Nazia, Kahlon, Babar, Svensson, Christer, Cervin, Anders, Höglund, Peter, Valdemarsson, Stig and Siesjö, Peter (2017). Quality of Life and Work Capacity Are Unrelated to Approach or Complications After Pituitary Surgery. World Neurosurgery, 108, 24-32. doi: 10.1016/j.wneu.2017.08.087
Chronic rhinosinusitis: a microbiome in dysbiosis and the search for alternative treatment options
Bordin, Amanda, Sidjabat, Hanna E., Cottrell, Kyra and Cervin, Anders (2016). Chronic rhinosinusitis: a microbiome in dysbiosis and the search for alternative treatment options. Microbiology Australia, 37 (3), 149-152. doi: 10.1071/MA16051
Melioidosis in a patient with chronic rhinosinusitis
Phillips, N. M., Cervin, A., Earnshaw, J. and Sidjabat, H. E. (2016). Melioidosis in a patient with chronic rhinosinusitis. Journal of Laryngology and Otology, 130 (S4), S60-S62. doi: 10.1017/S0022215116008276
Martensson, Anders, Greiff, Lennart, Lamei, Sepideh S., Lindstedt, Malin, Olofsson, Tobias C., Vasquez, Alejandra and Cervin, Anders (2016). Effects of a honeybee lactic acid bacterial microbiome on human nasal symptoms, commensals, and biomarkers. International Forum of Allergy and Rhinology, 6 (9), 956-963. doi: 10.1002/alr.21762
Sidjabat, Hanna E, Grahn Hakansson, Eva and Cervin, Anders (2016). Draft genome sequence of the oral commensal Streptococcus oralis 89a with interference activity against respiratory pathogens. Genome Announcements, 4 (1) e01546-15, e01546-15. doi: 10.1128/genomeA.01546-15
Gudnadottir, G., Ehnhage, A., Bende, M., Andersson, M., Cervin, A., Cardell, L.O. and Hellgren, J. (2015). Healthcare provider contact for children with symptoms of sleep-disordered breathing: a population survey. Journal of Laryngology and Otology, 130 (3), 296-301. doi: 10.1017/S0022215115003370
Greiff, Lennart, Ahlström-Emanuelsson, Cecilia, Alenäs, Mikaela, Almqvist, Gun, Andersson, Morgan, Cervin, Anders, Dolata, Jan, Lindgren, Sam, Mårtensson, Anders, Young, Barbara and Widegren, Henrik (2015). Biological effects and clinical efficacy of a topical Toll-like receptor 7 agonist in seasonal allergic rhinitis: a parallel group controlled phase IIa study. Inflammation Research, 64 (11), 903-915. doi: 10.1007/s00011-015-0873-2
Sidjabat, Hanna E., Cottrell, Kyra and Cervin, Anders (2015). Draft Genome Sequences of Burkholderia pseudomallei and Staphylococcus aureus, Isolated from a Patient with Chronic Rhinosinusitis. Genome Announcements, 3 (5) e01075-15. doi: 10.1128/genomeA.01075-15
Phan, N.T., Cabot, P.J., Wallwork, B.D., Cervin, A.U. and Panizza, B.J. (2015). Cellular and molecular mechanisms of chronic rhinosinusitis and potential therapeutic strategies: review on cytokines, nuclear factor kappa B and transforming growth factor beta. Journal of Laryngology and Otology, 129 (S3), S2-S7. doi: 10.1017/S0022215115001322
Tuckett, P. and Cervin, A. (2015). Reducing the number of rigid bronchoscopies performed in suspected foreign body aspiration cases via the use of chest computed tomography: is it safe? A literature review. Journal of Laryngology and Otology, 129 (S1), S1-S7. doi: 10.1017/S0022215114002862
Thulesius, Helle L., Cervin, Anders and Jessen, Max (2014). Treatment with a topical glucocorticoid, budesonide, reduced the variability of rhinomanometric nasal airway resistance. Rhinology, 52 (1), 19-24. doi: 10.4193/Rhino12.180
Cervin, Anders and Wallwork, Ben (2014). Efficacy and safety of long-term antibiotics (macrolides) for the treatment of chronic rhinosinusitis. Current Allergy and Asthma Reports, 14 (3) 416, 416.1-416.7. doi: 10.1007/s11882-013-0416-2
Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis
Greiff, Lennart, Cervin, Anders, Ahlstrom-Emanuelsson, Cecilia, Almqvist, Gun, Andersson, Morgan, Dolata, Jan, Eriksson, Leif, Hogestatt, Edward, Kallen, Anders, Norlen, Per, Sjolin, Inga-Lisa and Widegren, Henrik (2012). Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis. Respiratory Research, 13 53, 53.1-53.10. doi: 10.1186/1465-9921-13-53
Cardell, Lars Olaf, Wickman, Magnus, Hellgren, Johan, Cervin, Anders, Stjärne, Pär, Holmström, Mats, Dahlén, Barbro, Bjermer, Leif and Dahlén, Sven-Erik (2012). Internationella riktlinjer för allergisk rinit har uppdaterats: Nu presenteras behandlingsalgoritm anpassad till svenska förhållanden. Lakartidningen, 109 (12), 622-624.
Fokkens, Wytske J., Lund, Valerie J., Mullol, Joachim, Bachert, Claus, Alobid, Isam, Baroody, Fuad, Cohen, Noam, Cervin, Anders, Douglas, Richard, Gevaert, Philippe, Georgalas, Christos, Goossens, Herman, Harvey, Richard, Hellings, Peter, Hopkins, Claire, Jones, Nick, Joos, Guy, Kalogjera, Livije, Kern, Bob, Kowalski, Marek, Price, David, Riechelmann, Herbert, Schlosser, Rodney, Senior, Brent, Thomas, Mike, Toskala, Elina, Voegels, Richard, Wang, De Yun and Wormald, Peter John (2012). EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology, 50 (1), 1-12. doi: 10.4193/rhino50e2
European position paper on rhinosinusitis and nasal polyps 2012
Fokkens, Wytske J., Lund, Valerie J., Mullol, Joachim, Bachert, Claus, Alobid, Isam, Baroody, Fuad, Cohen, Noam, Cervin, Anders, Douglas, Richard, Gevaert, Philippe, Georgalas, Christos, Goossens, Herman, Harvey, Richard, Hellings, Peter, Hopkins, Claire, Jones, Nick, Joos, Guy, Kalogjera, Livije, Kern, Bob, Kowalski, Marek, Price, David, Riechelmann, Herbert, Schlosser, Rodney, Senior, Brent, Thomas, Mike, Toskala, Elina, Voegels, Richard, Wang, De Yun and Wormald, Peter John (2012). European position paper on rhinosinusitis and nasal polyps 2012. Rhinology, 50 (Supp. 3), 4-305.
Thulesius, H. L., Cervin, A. and Jessen, M. (2012). The importance of side difference in nasal obstruction and rhinomanometry: a retrospective correlation of symptoms and rhinomanometry in 1000 patients. Clinical Otolaryngology, 37 (1), 17-22. doi: 10.1111/j.1749-4486.2011.02420.x
Can we always trust rhinomanometry?
Thulesius, H. L., Cervin, A. and Jessen, M. (2011). Can we always trust rhinomanometry?. Rhinology, 49 (1), 46-52. doi: 10.4193/Rhino10.027
NOD-like receptors in the human upper airways: a potential role in nasal polyposis
Mansson, A., Bogefors, J., Cervin, A., Uddman, R. and Cardell, L. O. (2011). NOD-like receptors in the human upper airways: a potential role in nasal polyposis. Allergy: European Journal of Allergy and Clinical Immunology, 66 (5), 621-628. doi: 10.1111/j.1398-9995.2010.02527.x
Cervin, Anders (2010). Is it time to abandon chronic rhinosinusitis? (Or at least to introduce the term unexplained chronic rhinosinusitis). Rhinology, 48 (1), 123-124.
Allergic rhinitis and the common cold - high cost to society
Hellgren, J., Cervin, A., Nordling, S., Bergman, A. and Cardell, L. O. (2010). Allergic rhinitis and the common cold - high cost to society. Allergy: European Journal of Allergy and Clinical Immunology, 65 (6), 776-783. doi: 10.1111/j.1398-9995.2009.02269.x
Cervin, Anders, Wallwork, Ben, Mackay-Sim, Alan, Coman, William B. and Greiff, Lennart (2009). Effects of long-term clarithromycin treatment on lavage-fluid markers of inflammation in chronic rhinosinusitis. Clinical Physiology and Functional Imaging, 29 (2), 136-142. doi: 10.1111/j.1475-097X.2008.00848.x
Genes regulating molecular and cellular functions in noninfectious nonallergic rhinitis
Cardell, L. O., Andersson, M., Cervin, A., Davidsson, A., Hellgren, J., Holmstrom, M., Lundblad, L., Stierna, P., Stjarne, P., Adner, M. and SRFA study group (2009). Genes regulating molecular and cellular functions in noninfectious nonallergic rhinitis. Allergy: European Journal of Allergy and Clinical Immunology, 64 (9), 1301-1308. doi: 10.1111/j.1398-9995.2009.02009.x
Macrolide therapy of chronic rhinosinusitis
Cervin, Anders and Wallwork, Ben (2007). Macrolide therapy of chronic rhinosinusitis. Rhinology, 45 (4), 259-267.
Anti-inflammatory effects of macrolide antibiotics in the treatment of chronic rhinosinusitis
Cervin A. and Wallwork B. (2005). Anti-inflammatory effects of macrolide antibiotics in the treatment of chronic rhinosinusitis. Otolaryngologic Clinics of North America, 38 (6), 1339-1350. doi: 10.1016/j.otc.2005.08.002
Wallwork, Ben, Coman, William, Mackay-Sim, Alan and Cervin, Anders (2004). Effect of clarithromycin on nuclear factor-kappa B and transforming growth factor-beta in chronic rhinosinusitis. The Laryngoscope, 114 (2), 286-290. doi: 10.1097/00005537-200402000-00019
Cervin A., Hansson C., Greiff L. and Andersson M. (2003). Nasal septal perforations during treatment with topical nasal glucocorticosteroids are generally not associated with contact allergy to steroids. ORL, 65 (2), 103-105. doi: 10.1159/000070774
Cervin, Anders, Kalm, Olof, Sandkull, Per and Lindberg, Sven (2002). One-year low-dose erythromycin treatment of persistent chronic sinusitis after sinus surgery: clinical outcome and effects on mucociliary parameters and nasal nitric oxide. Otolaryngology - Head and Neck Surgery, 126 (5), 481-489. doi: 10.1067/mhn.2002.124849
Andersson, Jens A., Cervin, Anders, Lindberg, Sven, Uddman, Rolf and Cardell, Lars Olaf (2002). A decrease in maxillary sinus pressure, as seen in upper airway allergy or infection, results in an increase in upper airway nitric oxide levels. Acta Oto-Laryngologica, 122 (5), 520-523. doi: 10.1080/00016480260092336
Acute exudative inflammation and nasally exhaled nitric oxide are two independent phenomena
Cervin, Anders, Greiff, Lennart, Lindberg, Sven and Andersson, Morgan (2002). Acute exudative inflammation and nasally exhaled nitric oxide are two independent phenomena. ORL, 64 (1), 26-31. doi: 10.1159/000049264
The paranasal sinuses as reservoirs for nitric oxide
Andersson J.A., Cervin A., Lindberg S., Uddman R. and Cardell L.O. (2002). The paranasal sinuses as reservoirs for nitric oxide. Acta Oto-Laryngologica, 122 (8), 861-865. doi: 10.1080/003655402/000028053
Cervin, A, Akerlund, A, Greiff, L and Andersson, M (2001). The effect of intranasal budesonide spray on mucosal blood flow measured with Laser Doppler flowmetry. Rhinology, 39 (1), 13-16.
Evaluation of surgery for acromegaly: role of intraoperative growth hormone measurement?
Valdemarsson, S., Ljunggren, S., Cervin, A., Svensson, C., Isaksson, A., Nordstrom, C. -H. and Siesjo, P. (2001). Evaluation of surgery for acromegaly: role of intraoperative growth hormone measurement?. Scandinavian Journal of Clinical and Laboratory Investigation, 61 (6), 459-470. doi: 10.1080/00365510152567103
Cervin A. (2001). The anti-inflammatory effect of erythromycin and its derivatives, with special reference to nasal polyposis and chronic sinusitis. Acta Oto-Laryngologica, 121 (1), 83-92. doi: 10.1080/000164801300006326
Cervin, A, Onnerfalt, J, Edvinsson, L and Grundemar, L (1999). Functional effects of neuropeptide Y receptors on blood flow and nitric oxide levels in the human nose. American Journal of Respiratory and Critical Care Medicine, 160 (5), 1724-1728.
Janson H., Carlen B., Cervin A., Forsgren A., Magnusdottir A.B., Lindberg S. and Runer T. (1999). Effects on the ciliated epithelium of protein D-producing and - nonproducing nontypeable Haemophilus influenzae in nasopharyngeal tissue cultures. Journal of Infectious Diseases, 180 (3), 737-746. doi: 10.1086/314921
Nitric oxide is a regulator of mucociliary activity in the upper respiratory tract
Runer, T, Cervin, A, Lindberg, S and Uddman, R (1998). Nitric oxide is a regulator of mucociliary activity in the upper respiratory tract. Otolaryngology-Head and Neck Surgery, 119 (3), 278-287. doi: 10.1016/S0194-5998(98)70063-4
Cervin, A and Lindberg, S (1998). Changes in mucociliary activity may be used to investigate the airway-irritating potency of volatile anaesthetics. British Journal of Anaesthesia, 80 (4), 475-480.
Cervin A. and Lindgren S. (1998). The effect of selective phosphodiesterase inhibitors on mucociliary activity in the upper and lower airways in vitro. Auris Nasus Larynx, 25 (3), 269-276. doi: 10.1016/S0385-8146(98)00010-8
Lindberg, S, Cervin, A and Runer, T (1997). Low levels of nasal nitric oxide (NO) correlate to impaired mucociliary function in the upper airways. Acta Oto-Laryngologica, 117 (5), 728-734. doi: 10.3109/00016489709113468
Nitric oxide (NO) production in the upper airways is decreased in chronic sinusitis
Lindberg, S, Cervin, A and Runer, T (1997). Nitric oxide (NO) production in the upper airways is decreased in chronic sinusitis. Acta Oto-Laryngologica, 117 (1), 113-117. doi: 10.3109/00016489709118001
Lindberg, S, Cervin, A, Runer, T and Thomasson, L (1996). Recordings of mucociliary activity in vivo: Benefit of fast Fourier transformation of the photoelectric signal. Annals of Otology Rhinology and Laryngology, 105 (9), 734-745.
Sinonasal T-cell lymphoma and Wegener's granulomatosis: Aspects in early differential diagnosis
Cervin, A, Dictor, M and Kalm, O (1996). Sinonasal T-cell lymphoma and Wegener's granulomatosis: Aspects in early differential diagnosis. American Journal of Rhinology, 10 (4), 239-246. doi: 10.2500/105065896782103126
Dictor, M, Cervin, A, Kalm, O and Rambech, E (1996). Sinonasal T-cell lymphoma in the differential diagnosis of lethal midline granuloma using in situ hybridization for Epstein-Barr virus RNA. Modern Pathology, 9 (1), 7-14.
Effects of Halothane On Mucociliary Activity In-Vivo
Cervin, A, Lindberg, S and Mercke, U (1995). Effects of Halothane On Mucociliary Activity In-Vivo. Otolaryngology-Head and Neck Surgery, 112 (6), 714-722.
Cyclic Adenosine-Monophosphate Stimulation of Mucociliary Activity in the Upper Airways In-Vivo
Cervin, A, Lindberg, S, Dolata, J and Mercke, U (1995). Cyclic Adenosine-Monophosphate Stimulation of Mucociliary Activity in the Upper Airways In-Vivo. Annals of Otology Rhinology and Laryngology, 104 (5), 388-393.
Cervin, A, Lindberg, S, Mercke, U and Uddman, R (1992). Neuropeptide-Y in the Rabbit Maxillary Sinus Modulates Cholinergic Acceleration of Mucociliary Activity. Acta Oto-Laryngologica, 112 (5), 872-881. doi: 10.3109/00016489209137486
Cervin, A (1992). Neuropeptide-Y 16-36 Inhibits Mucociliary Activity But Does Not Affect Blood-Flow in the Rabbit Maxillary Sinus Invivo. Regulatory Peptides, 39 (2-3), 237-246. doi: 10.1016/0167-0115(92)90544-5
Sympathetic-Nerve Stimulation Influences Mucociliary Activity in the Rabbit Maxillary Sinus
Cervin, A, Lindberg, S and Mercke, U (1991). Sympathetic-Nerve Stimulation Influences Mucociliary Activity in the Rabbit Maxillary Sinus. Acta Physiologica Scandinavica, 143 (4), 405-411. doi: 10.1111/j.1748-1716.1991.tb09252.x
The Effect of Neuropeptide-Y On Mucociliary Activity in the Rabbit Maxillary Sinus
Cervin, A, Lindberg, S and Mercke, U (1991). The Effect of Neuropeptide-Y On Mucociliary Activity in the Rabbit Maxillary Sinus. Acta Oto-Laryngologica, 111 (5), 960-966. doi: 10.3109/00016489109138437
Vip Potentiates Cholinergic Effects On the Mucociliary System in the Maxillary Sinus
Lindberg, S, Cervin, A, Mercke, U and Uddman, R (1988). Vip Potentiates Cholinergic Effects On the Mucociliary System in the Maxillary Sinus. Otolaryngology-Head and Neck Surgery, 99 (4), 401-407.
Relations Between Blood-Flow and Mucociliary Activity in the Rabbit Maxillary Sinus
Cervin, A, Bende, M, Lindberg, S, Mercke, U and Olsson, P (1988). Relations Between Blood-Flow and Mucociliary Activity in the Rabbit Maxillary Sinus. Acta Oto-Laryngologica, 105 (3-4), 350-356. doi: 10.3109/00016488809097018
Rising incidence of head and neck mucosal melanoma in Australia
Youssef, D., Vasani, S., Marquess, J. and Cervin, A. (2016). Rising incidence of head and neck mucosal melanoma in Australia. 65th Annual Scientific Meeting of the Australian-Society-of-Otolaryngology-Head-and-Neck-Surgery, Sydney Australia, Mar 07-10, 2015. Cambridge, United Kingdom: Cambridge University Press. doi: 10.1017/S0022215116009385
Regulation of mucociliary activity in the upper airways by nitric oxide - Clinical implications
Lindberg, S, Carlen, B, Cervin, A, Cramnert, C and Runer, T (1998). Regulation of mucociliary activity in the upper airways by nitric oxide - Clinical implications. International Congress on Cilia, Mucus, and Mucociliary Interactions, in Honor of Professor Alex Silberberg, Jerusalem Israel, Feb 23-27, 1997. MARCEL DEKKER.
(2021–2025) NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
Development of Phage Therapy to Combat Chronic Otitis Media in Indigenous Children
(2020–2024) NHMRC IDEAS Grants
(2017–2027) Garnett Passe/Rodney Williams Memorial Foundation
Microbiota of the human sinuses: Its role in health and disease
(2015–2019) Garnett Passe/Rodney Williams Memorial Foundation
The role of the bacterial, fungal and viral sinus microbiome in chronic rhinosinusitis patients
(2015) Royal Brisbane and Women's Hospital
Testing a sinonasal microbiome transplant as a therapy for Chronic Rhinosinusitis by randomised controlled trial
Master Philosophy — Principal Advisor
Other advisors:
Simultaneous comparison of novel and traditional methods for the diagnosis of Laryngopharyngeal Reflux: A prospective cohort study
Doctor Philosophy — Associate Advisor
(2021) Doctor Philosophy — Principal Advisor
Other advisors:
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
Probiotic treatment of Chronic Rhinosinusits
The overall aim of the project is to improve quality of life in patients suffering from Chronic RhinoSinusitis (CRS). Specifically by manipulating mucosal immunology and reducing the load of microbial pathogens in CRS by topical administration of probiotic bacterial strains. You will work in a stimulating environment in close relationship with patients, ENT surgeons, microbiologists and other researchers. The project have international collaborators in the Netherlands and Sweden. The project is truly translational you will acquire skills in clinical trials (GCP), as well as gaining laboratory experience in microbiology and cytokine analysis.