Dr Patricia Carreira Moreno

Honorary Fellow

Mater Research Institute-UQ
Faculty of Medicine

Overview

Dr Patricia Carreira is a McGuckin Research Fellow in the Genome Plasticity and Disease lab at Mater Research. She received a bachelor’s degree in biology and a master’s degree in molecular medicine at the University of Santiago de Compostela (Spain), and a PhD in biochemistry and molecular biology at the University of Granada (Spain). Patricia joined Mater Research in early 2013 to work with Prof Geoff Faulkner investigating the role of mobile elements (“Jumping Genes”) in cancer.

Her research showed that while mobile elements are silenced in adult tissues, they are active in multiple cancer types. Yet the impact of their activation on cancer is unknown. Patricia’s research imitates aggressive tumour conditions using cancer models to investigate why mobile elements are activated in cancer and how this activation is influencing cancer progression. Her research aims to lay the foundations for the development of mobile element-based diagnostic tools and therapies for multiple cancer types.

Patricia is passionate about science communication, community engagement and advocacy for women in science.

Publications

  • Schauer, Stephanie N., Carreira, Patricia E., Shukla, Ruchi, Gerhardt, Daniel J., Gerdes, Patricia, Sanchez-Luque, Francisco J., Nicoli, Paola, Kindlova, Michaela, Ghisletti, Serena, Santos, Alexandre Dos, Rapoud, Delphine, Samuel, Didier, Faivre, Jamila, Ewing, Adam D., Richardson, Sandra R. and Faulkner, Geoffrey J. (2018) L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis. Genome Research, 28 5: 639-653. doi:10.1101/gr.226993.117

  • Nguyen, Thu H.M., Carreira, Patricia E., Sanchez-Luque, Francisco J., Schauer, Stephanie N., Fagg, Allister C., Richardson, Sandra R., Davies, Claire M., Jesuadian, J. Samuel, Kempen, Marie-Jeanne H.C., Troskie, Robin-Lee, James, Cini, Beaven, Elizabeth A., Wallis, Tristan P., Coward, Jermaine I.G., Chetty, Naven P., Crandon, Alexander J., Venter, Deon J., Armes, Jane E., Perrin, Lewis C., Hooper, John D., Ewing, Adam D., Upton, Kyle R. and Faulkner, Geoffrey J. (2018) L1 retrotransposon heterogeneity in ovarian tumor cell evolution. Cell Reports, 23 13: 3730-3740. doi:10.1016/j.celrep.2018.05.090

  • Carreira, Patricia E., Richardson, Sandra R. and Faulkner, Geoffrey J. (2014) L1 retrotransposons, cancer stem cells and oncogenesis. FEBS Journal, 281 1: 63-73. doi:10.1111/febs.12601

View all Publications

Publications

Featured Publications

  • Schauer, Stephanie N., Carreira, Patricia E., Shukla, Ruchi, Gerhardt, Daniel J., Gerdes, Patricia, Sanchez-Luque, Francisco J., Nicoli, Paola, Kindlova, Michaela, Ghisletti, Serena, Santos, Alexandre Dos, Rapoud, Delphine, Samuel, Didier, Faivre, Jamila, Ewing, Adam D., Richardson, Sandra R. and Faulkner, Geoffrey J. (2018) L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis. Genome Research, 28 5: 639-653. doi:10.1101/gr.226993.117

  • Nguyen, Thu H.M., Carreira, Patricia E., Sanchez-Luque, Francisco J., Schauer, Stephanie N., Fagg, Allister C., Richardson, Sandra R., Davies, Claire M., Jesuadian, J. Samuel, Kempen, Marie-Jeanne H.C., Troskie, Robin-Lee, James, Cini, Beaven, Elizabeth A., Wallis, Tristan P., Coward, Jermaine I.G., Chetty, Naven P., Crandon, Alexander J., Venter, Deon J., Armes, Jane E., Perrin, Lewis C., Hooper, John D., Ewing, Adam D., Upton, Kyle R. and Faulkner, Geoffrey J. (2018) L1 retrotransposon heterogeneity in ovarian tumor cell evolution. Cell Reports, 23 13: 3730-3740. doi:10.1016/j.celrep.2018.05.090

  • Carreira, Patricia E., Richardson, Sandra R. and Faulkner, Geoffrey J. (2014) L1 retrotransposons, cancer stem cells and oncogenesis. FEBS Journal, 281 1: 63-73. doi:10.1111/febs.12601

Book Chapter

  • Thomas, María del Carmen, Macías, F., Carreira, P., Rojas Ruiz, Beatriz, García-Cañadas, Marta and López López, Manuel Carlos (2011). Elementos móviles de ADN: mochileros en el genoma.. In Vicente Larraga Rodríguez de Vera (Ed.), La Lucha frente a las enfermedades de la pobreza. Responsabilidad y necesidad (pp. 147-158) Spain: Fundación BBVA.

Journal Article

  • Sanchez-Luque, Francisco J., Kempen, Marie-Jeanne H.C., Gerdes, Patricia, Vargas-Landin, Dulce B., Richardson, Sandra R., Troskie, Robin-Lee, Jesuadian, J. Samuel, Cheetham, Seth W., Carreira, Patricia E., Salvador-Palomeque, Carmen, García-Cañadas, Marta, Muñoz-Lopez, Martin, Sanchez, Laura, Lundberg, Mischa, Macia, Angela, Heras, Sara R., Brennan, Paul M., Lister, Ryan, Garcia-Perez, Jose L., Ewing, Adam D. and Faulkner, Geoffrey J. (2019) LINE-1 Evasion of epigenetic repression in humans. Molecular Cell, 75 3: 590-604.e12. doi:10.1016/j.molcel.2019.05.024

  • Schauer, Stephanie N., Carreira, Patricia E., Shukla, Ruchi, Gerhardt, Daniel J., Gerdes, Patricia, Sanchez-Luque, Francisco J., Nicoli, Paola, Kindlova, Michaela, Ghisletti, Serena, Santos, Alexandre Dos, Rapoud, Delphine, Samuel, Didier, Faivre, Jamila, Ewing, Adam D., Richardson, Sandra R. and Faulkner, Geoffrey J. (2018) L1 retrotransposition is a common feature of mammalian hepatocarcinogenesis. Genome Research, 28 5: 639-653. doi:10.1101/gr.226993.117

  • Nguyen, Thu H.M., Carreira, Patricia E., Sanchez-Luque, Francisco J., Schauer, Stephanie N., Fagg, Allister C., Richardson, Sandra R., Davies, Claire M., Jesuadian, J. Samuel, Kempen, Marie-Jeanne H.C., Troskie, Robin-Lee, James, Cini, Beaven, Elizabeth A., Wallis, Tristan P., Coward, Jermaine I.G., Chetty, Naven P., Crandon, Alexander J., Venter, Deon J., Armes, Jane E., Perrin, Lewis C., Hooper, John D., Ewing, Adam D., Upton, Kyle R. and Faulkner, Geoffrey J. (2018) L1 retrotransposon heterogeneity in ovarian tumor cell evolution. Cell Reports, 23 13: 3730-3740. doi:10.1016/j.celrep.2018.05.090

  • Richardson, Sandra R., Gerdes, Patricia, Gerhardt, Daniel J., Sanchez-Luque, Francisco J., Bodea, Gabriela-Oana, Muñoz-Lopez, Martin, Jesuadian, J. Samuel, Kempen, Marie-Jeanne H. C., Carreira, Patricia E., Jeddeloh, Jeffrey A., Garcia-Perez, Jose L., Kazazian Jr., Haig H., Ewing, Adam D. and Faulkner, Geoffrey J. (2017) Heritable L1 retrotransposition in the mouse primordial germline and early embryo. Genome Research, 27 8: 1395-1405. doi:10.1101/gr.219022.116

  • Carreira, Patricia E., Ewing, Adam D., Li, Guibo, Schauer, Stephanie N., Upton, Kyle R., Fagg, Allister C., Morell, Santiago, Kindlova, Michaela, Gerdes, Patricia, Richardson, Sandra R., Li, Bo, Gerhardt, Daniel J., Wang, Jun, Brennan, Paul M. and Faulkner, Geoffrey J. (2016) Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme. Mobile DNA, 7 1: 1-14. doi:10.1186/s13100-016-0076-6

  • Jose Sanchez-Luque, Francisco, Carlos Lopez, Manuel, Eugenia Carreira, Patricia, Alonso, Carlos and Carmen Thomas, Maria (2014) The wide expansion of hepatitis delta virus-like ribozymes throughout trypanosomatid genomes is linked to the spreading of L1Tc/ingi clade mobile elements. BMC Genomics, 15 1: . doi:10.1186/1471-2164-15-340

  • Carreira, Patricia E., Richardson, Sandra R. and Faulkner, Geoffrey J. (2014) L1 retrotransposons, cancer stem cells and oncogenesis. FEBS Journal, 281 1: 63-73. doi:10.1111/febs.12601