The University of Queensland

Protein phosphorylation

Ellis, Jonathan J. and Kobe, Boštjan (2013). Protein phosphorylation. Encyclopedia of biophysics. (pp. 2037-2040) edited by Gordon C. K. Roberts. Berlin, Germany: Springer-Verlag. doi: 10.1007/978-3-642-16712-6_184

Principles of kinase regulation

Kobe, Bostjan and Kemp, Bruce E. (2010). Principles of kinase regulation. Handbook of Cell Signaling, 2/e. (pp. 559-563) Elsevier Inc.. doi: 10.1016/B978-0-12-374145-5.00074-7

Hybrid methods for protein structure prediction

Mouradov, Dmitri, Kobe, Bostjan, Dixon, Nicholas E. and Huber, Thomas (2010). Hybrid methods for protein structure prediction. Introduction to protein structure prediction: Methods and algorithms. (pp. 265-277) edited by Huzefa Rangwala and George Karypis. Hoboken, New Jersey, USA: John Wiley and Sons, Inc.. doi: 10.1002/9780470882207.ch12

Substrates of Cyclic Nucleotide-Dependent Protein Kinases

W. Saunders, Neil F., Brinkworth, Ross I., Kemp, Bruce E. and Kobe, Bostjan (2010). Substrates of Cyclic Nucleotide-Dependent Protein Kinases. Handbook of Cell Signaling. (pp. 1489-1495) Elsevier. doi: 10.1016/b978-0-12-374145-5.00182-0

Study of protein three-dimensional structure and dynamics determination using peptide amide hydrogen/deuterium exchange mass spectrometry (DXMS) and chemical cross-linking with mass spectrometry to constrain molecular modeling

Li, Sheng, Mouradov, Dmitri, King, Gordon, Liu, Tong, Ross, Ian, Kobe, Bostjan, Woods, Virgil L. and Huber, Thomas (2009). Study of protein three-dimensional structure and dynamics determination using peptide amide hydrogen/deuterium exchange mass spectrometry (DXMS) and chemical cross-linking with mass spectrometry to constrain molecular modeling. Structural Bioinformatics. (pp. 171-206) edited by Gu, Jenny and Bourne, Phillip E.. Hoboken, N.J.: Wiley-Blackwell.

A general target selection method for crystallographic proteomics

Robin, G., Cowieson, N.P., Guncar, G., Forwood, J.K., Listwan, P., Hume, D.A., Kobe, B., Martin, J.L. and Huber, T.L. (2008). A general target selection method for crystallographic proteomics. Structural Proteomics: High-Throughput Methods. (pp. 27-35) edited by Kobe, B., Guss, M. and Huber, T.L.. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_2

A medium or high throughput protein refolding assay

Cowieson, N. P., Wensley, B., Robin, G., Guncar, G., Forwood, J. K., Hume, D. A., Kobe, B. and Martin, J. L. (2008). A medium or high throughput protein refolding assay. Structural Proteomics: High throughput Methods. (pp. 269-275) edited by Bostjan Kobe, Mitchell Guss and Thomas Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_17

Increasing protein crystallization screening success with heterogeneous nucleating agents

Thakur, A. S., Newman, J., Martin, J. L. and Kobe, B. (2008). Increasing protein crystallization screening success with heterogeneous nucleating agents. Structural Proteomics: High-throughput Methods. (pp. 403-409) edited by B. Kobe, M. Guss and T. Huber. USA: Humana Press.

Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland

Meng, Weining, Forwood, Jade K., Guncar, Gregor, Robin, Gautier, Cowieson, Nathan P., Listwan, Pawel, Mouradov, Dmitri, King, Gordon, Ross, lan L., Robinson, Jodie, Puri, Munish, Hill, Justine M., Kellie, Stuart, Huber, Thomas, Hume, David A., Martin, Jennifer L. and Kobe, Bostjan (2008). Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland. Structural proteomics: High-throughput methods. (pp. 577-587) edited by B. Kobe, M. Guss and T. L. Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_38

Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling

Mouradov, Dmitri, King. Gordon, Ross, Ian L., Forwood, Jade K., Hume, David A., Sinz, Andrea, Martin, Jennifer L., Kobe, Bostjan and Huber, Thomas L. (2008). Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling. Structural Proteomics: High Throughput Methods. (pp. 459-474) edited by Bostjan Kobe, Mitchell Guss and Thomas L. Huber. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-058-8_31

Peptide substrates of cyclic nucleotide-dependent protein kinases

Brinkworth, R. I., Kobe, B. and Kemp, B.L.E. (2004). Peptide substrates of cyclic nucleotide-dependent protein kinases. Handbook of Cell Signaling. (pp. 495-499) edited by R. A. Bradshaw and E. A. Dennis. USA: Academic Press. doi: 10.1016/B978-012124546-7/50563-5

Principles of kinase regulation

Kobe, B. and Kemp, B. E. (2004). Principles of kinase regulation. Handbook of Cell Signaling Vol 1. (pp. 539-542) edited by R. A. Bradshaw and E. A. Dennis. USA: Academic Press.

Principles of Kinase Regulation

Kobe, Bostjan and Kemp, Bruce E. (2003). Principles of Kinase Regulation. Handbook of Cell Signaling. (pp. 539-542) Elsevier Inc.. doi: 10.1016/B978-012124546-7/50450-2

Conserved sequence motifs in protein kinase families

Brinkworth, R. I., Breinl, R. A. and Kobe, B. (2002). Conserved sequence motifs in protein kinase families. Recent Research Developments in Protein Folding Stability and Design. (pp. 67-77) edited by M Michael Gromiha and S Selvaraj. Trivandrum, India: Research Signpost.

Structure and Regulation of Phenylalanine Hydroxylase, and Implications for Related Enzymes

Kobe, Bostjan, Jennings, Ian G. and Cotton, Richard G. H. (2002). Structure and Regulation of Phenylalanine Hydroxylase, and Implications for Related Enzymes. Chemistry and Biology of Pteridines and Folates. (pp. 79-84) Boston, MA: Springer US. doi: 10.1007/978-1-4615-0945-5_13

Protein serine/threonine kinases

Heierhorst, Jorg, Pearson, Richard, Horne, James, Bozinovski, Steven, Kobe, Bostjan and Kemp, Bruce E. (2000). Protein serine/threonine kinases. Principles of Molecular Regulation. (pp. 297-310) edited by Michael Conn P. and Anthony R. Means. Totowa, N.J., USA: Humana Press. doi: 10.1007/978-1-59259-032-2_17

Crystallization of protein kinases and phosphatases

Kobe, Bostjan, Gleichmann, Thomas, Teh, Trazel, Heierhorst, Jorg and Kemp, Bruce E. (1999). Crystallization of protein kinases and phosphatases. Protein phosphorylation: A practical approach. (pp. 387-422) edited by D. Grahame Hardie. Oxford, UK: Oxford University Press.

3 Intrasteric regulation of protein kinases

Kobe, Boštjan, Heierhorst, Jörg and Kemp, Bruce E. (1997). 3 Intrasteric regulation of protein kinases. Advances in Second Messenger and Phosphoprotein Research. (pp. 29-40) Elsevier. doi: 10.1016/s1040-7952(97)80006-7

Conformations of wild-type and mutant OmpA signal sequences in membrane mimetic environments

Rizo, Josep, Blanco, Francisco, Kobe, Bostjan, Bruch, Martha D., Hoyt, David W. and Gierasch, Lila M. (1992). Conformations of wild-type and mutant OmpA signal sequences in membrane mimetic environments. Peptides. (pp. 265-267) Dordrecht: Springer Netherlands. doi: 10.1007/978-94-011-2264-1_94

Mildew RALPHs up in arms with cereals

Maruta, Natsumi, Outram, Megan A. and Kobe, Bostjan (2023). Mildew RALPHs up in arms with cereals. Proceedings of the National Academy of Sciences, 120 (36) e2311817120, 1-3. doi: 10.1073/pnas.2311817120

Toll/interleukin-1 receptor domains in bacterial and plant immunity

Li, Sulin, Manik, Mohammad K, Shi, Yun, Kobe, Bostjan and Ve, Thomas (2023). Toll/interleukin-1 receptor domains in bacterial and plant immunity. Current Opinion in Microbiology, 74 102316, 102316. doi: 10.1016/j.mib.2023.102316

A rust‐fungus Nudix hydrolase effector decaps mRNA in vitro and interferes with plant immune pathways

McCombe, Carl L., Catanzariti, Ann‐Maree, Greenwood, Julian R., Desai, Anna M., Outram, Megan A., Yu, Daniel S., Ericsson, Daniel J., Brenner, Steven E., Dodds, Peter N., Kobe, Bostjan, Jones, David A. and Williams, Simon J. (2023). A rust‐fungus Nudix hydrolase effector decaps mRNA in vitro and interferes with plant immune pathways. New Phytologist, 239 (1), 222-239. doi: 10.1111/nph.18727

TIR domain-associated nucleotides with functions in plant immunity and beyond

Maruta, Natsumi, Sorbello, Mitchell, Lim, Bryan Y. J., McGuinness, Helen Y., Shi, Yun, Ve, Thomas and Kobe, Bostjan (2023). TIR domain-associated nucleotides with functions in plant immunity and beyond. Current Opinion in Plant Biology, 73 102364, 102364. doi: 10.1016/j.pbi.2023.102364

Discovery of C-5 Pyrazole-Substituted Pyrrolopyridine Derivatives as Potent and Selective Inhibitors for Janus Kinase 1

Lang, Jia-Jia, Lv, You, Kobe, Bostjan, Chen, Hongfei, Tan, Yan, Chen, Limei, Wang, Xuechuan, Mi, Pengbing, Zheng, Xing and Lin, Ying-Wu (2023). Discovery of C-5 Pyrazole-Substituted Pyrrolopyridine Derivatives as Potent and Selective Inhibitors for Janus Kinase 1. Journal of Medicinal Chemistry, 66 (10), 6725-6742. doi: 10.1021/acs.jmedchem.3c00050

Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1

Tao, Le, Yang, Guangyue, Sun, Tiantian, Tao, Jie, Zhu, Chan, Yu, Huimin, Cheng, Yalan, Yang, Zongguo, Xu, Mingyi, Jiang, Yuefeng, Zhang, Wei, Wang, Zhiyi, Ma, Wenting, Wu, Liu, Xue, Dongying, Wang, Dongxue, Yang, Wentao, Zhao, Yongjuan, Horsefield, Shane, Kobe, Bostjan, Zhang, Zhe, Tang, Zongxiang, Li, Qigen, Zhai, Qiwei, Dooley, Steven, Seki, Ekihiro, Liu, Ping, Xu, Jianrong, Chen, Hongzhuan and Liu, Cheng (2023). Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1. Journal of Hepatology, 78 (4), 805-819. doi: 10.1016/j.jhep.2022.12.031

Exon shuffling potentiates a diverse repertoire of brown algal NB‐ARC‐TPR candidate immune receptor proteins via alternative splicing

Teng, Linhong, Liang, Miao, Wang, Chenghui, Li, Yan, Urbach, Jonathan M., Kobe, Bostjan, Xing, Qikun, Han, Wentao and Ye, Naihao (2023). Exon shuffling potentiates a diverse repertoire of brown algal NB‐ARC‐TPR candidate immune receptor proteins via alternative splicing. The Plant Journal, 114 (2), 246-261. doi: 10.1111/tpj.16131

SARM1-dependent axon degeneration: nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities

McGuinness, Helen Y., Gu, Weixi, Shi, Yun, Kobe, Bostjan and Ve, Thomas (2023). SARM1-dependent axon degeneration: nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities. The Neuroscientist, 107385842311625. doi: 10.1177/10738584231162508

Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products

Bayless, Adam M., Chen, Sisi, Ogden, Sam C., Xu, Xiaoyan, Sidda, John D., Manik, Mohammad K., Li, Sulin, Kobe, Bostjan, Ve, Thomas, Song, Lijiang, Grant, Murray, Wan, Li and Nishimura, Marc T. (2023). Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products. Science Advances, 9 (11) eade8487, 1-15. doi: 10.1126/sciadv.ade8487

Flow cytometric reporter assays provide robust functional analysis of signaling complexes

Muusse, Timothy W., Lee, Morris Y.L., Kim, Hyoyoung, Parat, Marie-Odile, Nanson, Jeffrey D., Kobe, Bostjan, Vajjhala, Parimala R. and Stacey, Katryn J. (2022). Flow cytometric reporter assays provide robust functional analysis of signaling complexes. Journal of Biological Chemistry, 298 (12) 102666, 102666. doi: 10.1016/j.jbc.2022.102666

Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP)

Foley, Gabriel, Mora, Ariane, Ross, Connie M., Bottoms, Scott, Sützl, Leander, Lamprecht, Marnie L., Zaugg, Julian, Essebier, Alexandra, Balderson, Brad, Newell, Rhys, Thomson, Raine E. S., Kobe, Bostjan, Barnard, Ross T., Guddat, Luke, Schenk, Gerhard, Carsten, Jörg, Gumulya, Yosephine, Rost, Burkhard, Haltrich, Dietmar, Sieber, Volker, Gillam, Elizabeth M. J. and Bodén, Mikael (2022). Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP). PL o S Computational Biology, 18 (10) e1010633, e1010633. doi: 10.1371/journal.pcbi.1010633

AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans

Wizrah, Maha S. I., Chua, Sheena M. H., Luo, Zhenyao, Manik, Mohammad K., Pan, Mengqi, Whyte, Jessica M. L., Robertson, Avril A. B., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2022). AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. Journal of Biological Chemistry, 298 (10) 102453, 102453. doi: 10.1016/j.jbc.2022.102453

Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling

Manik, Mohammad K., Shi, Yun, Li, Sulin, Zaydman, Mark A., Damaraju, Neha, Eastman, Samuel, Smith, Thomas G., Gu, Weixi, Masic, Veronika, Mosaiab, Tamim, Weagley, James S., Hancock, Steven J., Vasquez, Eduardo, Hartley-Tassell, Lauren, Kargios, Nestoras, Maruta, Natsumi, Lim, Bryan Y. J., Burdett, Hayden, Landsberg, Michael J., Schembri, Mark A., Prokes, Ivan, Song, Lijiang, Grant, Murray, DiAntonio, Aaron, Nanson, Jeffrey D., Guo, Ming, Milbrandt, Jeffrey, Ve, Thomas and Kobe, Bostjan (2022). Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling. Science, 377 (6614) eadc8969, 1-11. doi: 10.1126/science.adc8969

Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers

Holmes, Susannah, Kirkwood, Henry J., Bean, Richard, Giewekemeyer, Klaus, Martin, Andrew V., Hadian-Jazi, Marjan, Wiedorn, Max O., Oberthür, Dominik, Marman, Hugh, Adriano, Luigi, Al-Qudami, Nasser, Bajt, Saša, Barák, Imrich, Bari, Sadia, Bielecki, Johan, Brockhauser, Sandor, Coleman, Mathew A., Cruz-Mazo, Francisco, Danilevski, Cyril, Dörner, Katerina, Gañán-Calvo, Alfonso M., Graceffa, Rita, Fanghor, Hans, Heymann, Michael, Frank, Matthias, Kaukher, Alexander, Kim, Yoonhee, Kobe, Bostjan, Knoška, Juraj ... Darmanin, Connie (2022). Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers. Nature Communications, 13 (1) 4708, 1-13. doi: 10.1038/s41467-022-32434-6

Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform Chemicals

Lv, You, Zheng, Shan, Goldenzweig, Adi, Liu, Fengjiang, Gao, Yan, Yang, Xiuna, Kandale, Ajit, McGeary, Ross P., Williams, Simon, Kobe, Bostjan, Schembri, Mark A., Landsberg, Michael J., Wu, Bin, Brück, Thomas B., Sieber, Volker, Boden, Mikael, Rao, Zihe, Fleishman, Sarel J., Schenk, Gerhard and Guddat, Luke W. (2022). Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform Chemicals. Applied Biosciences, 1 (2), 163-178. doi: 10.3390/applbiosci1020011

Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli

Hancock, Steven J., Lo, Alvin W., Ve, Thomas, Day, Christopher J., Tan, Lendl, Mendez, Alejandra A., Phan, Minh-Duy, Nhu, Nguyen Thi Khanh, Peters, Kate M., Richards, Amanda C., Fleming, Brittany A., Chang, Chyden, Ngu, Dalton H. Y., Forde, Brian M., Haselhorst, Thomas, Goh, Kelvin G. K., Beatson, Scott A., Jennings, Michael P., Mulvey, Matthew A., Kobe, Bostjan and Schembri, Mark A. (2022). Ucl fimbriae regulation and glycan receptor specificity contribute to gut colonisation by extra-intestinal pathogenic Escherichia coli. PLoS Pathogens , 18 (6) e1010582, e1010582. doi: 10.1371/journal.ppat.1010582

Structural and biochemical characterization of Acinetobacter baumannii ZnuA

Alquethamy, Saleh, Ganio, Katherine, Luo, Zhenyao, Hossain, Sheikh I., Hayes, Andrew J., Ve, Thomas, Davies, Mark R., Deplazes, Evelyne, Kobe, Boštjan and McDevitt, Christopher A. (2022). Structural and biochemical characterization of Acinetobacter baumannii ZnuA. Journal of Inorganic Biochemistry, 231 111787, 1-11. doi: 10.1016/j.jinorgbio.2022.111787

The impact of chromate on Pseudomonas aeruginosa molybdenum homeostasis

Maunders, Eve A., Ngu, Dalton H. Y., Ganio, Katherine, Hossain, Sheikh I., Lim, Bryan Y. J., Leeming, Michael G., Luo, Zhenyao, Tan, Aimee, Deplazes, Evelyne, Kobe, Boštjan and McDevitt, Christopher A. (2022). The impact of chromate on Pseudomonas aeruginosa molybdenum homeostasis. Frontiers in Microbiology, 13 903146, 1-19. doi: 10.3389/fmicb.2022.903146

Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules

Shi, Yun, Kerry, Philip S., Nanson, Jeffrey D., Bosanac, Todd, Sasaki, Yo, Krauss, Raul, Saikot, Forhad K., Adams, Sarah E., Mosaiab, Tamim, Masic, Veronika, Mao, Xianrong, Rose, Faith, Vasquez, Eduardo, Furrer, Marieke, Cunnea, Katie, Brearley, Andrew, Gu, Weixi, Luo, Zhenyao, Brillault, Lou, Landsberg, Michael J., DiAntonio, Aaron, Kobe, Bostjan, Milbrandt, Jeffrey, Hughes, Robert O. and Ve, Thomas (2022). Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Molecular Cell, 82 (9), 1643-1659.e10. doi: 10.1016/j.molcel.2022.03.007

The transmembrane adaptor SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs

Liu, Liping, Lucas, Richard M., Nanson, Jeffrey D., Li, Yan, Whitfield, Jason, Curson, James E. B., Tuladhar, Neeraj, Alexandrov, Kirill, Mobli, Mehdi, Sweet, Matthew J., Kobe, Bostjan, Stow, Jennifer and Luo, Lin (2022). The transmembrane adaptor SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs. Journal of Biological Chemistry, 298 (5) 101857, 101857. doi: 10.1016/j.jbc.2022.101857

Editorial: Evolution of Innate Immunity in Eukarya: Advances and Implications

Scholz, Jean L., Eleftherianos, Ioannis and Kobe, Bostjan (2022). Editorial: Evolution of Innate Immunity in Eukarya: Advances and Implications. Frontiers in Immunology, 13 879429, 879429. doi: 10.3389/fimmu.2022.879429

Crystal structure of the Toll/interleukin‐1 receptor (TIR) domain of IL‐1R10 provides structural insights into TIR domain signaling

Nimma, Surekha, Gu, Weixi, Manik, Mohammad K., Ve, Thomas, Nanson, Jeffrey D. and Kobe, Bostjan (2022). Crystal structure of the Toll/interleukin‐1 receptor (TIR) domain of IL‐1R10 provides structural insights into TIR domain signaling. FEBS Letters, 596 (7), 886-897. doi: 10.1002/1873-3468.14288

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages

Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166

Structural basis of NLR activation and innate immune signalling in plants

Maruta, Natsumi, Burdett, Hayden, Lim, Bryan Y. J., Hu, Xiahao, Desa, Sneha, Manik, Mohammad Kawsar and Kobe, Bostjan (2022). Structural basis of NLR activation and innate immune signalling in plants. Immunogenetics, 74 (1), 5-26. doi: 10.1007/s00251-021-01242-5

Neurotoxin-mediated ­­potent activation of the axon degeneration regulator SARM1

Loreto, Andrea, Angeletti, Carlo, Gu, Weixi, Osborne, Andrew, Nieuwenhuis, Bart, Gilley, Jonathan, Arthur-Farraj, Peter, Merlini, Elisa, Amici, Adolfo, Luo, Zhenyao, Hartley-Tassell, Lauren, Ve, Thomas, Desrochers, Laura M, Wang, Qi, Kobe, Bostjan, Orsomando, Giuseppe and Coleman, Michael P (2021). Neurotoxin-mediated ­­potent activation of the axon degeneration regulator SARM1. eLife, 10 e72823. doi: 10.7554/elife.72823

Structural evolution of TIR-domain signalosomes

Nimma, Surekha, Gu, Weixi, Maruta, Natsumi, Li, Yan, Pan, Mengqi, Saikot, Forhad Karim, Lim, Bryan Y. J., McGuinness, Helen Ying, Zaoti, Zannati Ferdous, Li, Sulin, Desa, Sneha, Manik, Mohammad Kawsar, Nanson, Jeffrey D. and Kobe, Bostjan (2021). Structural evolution of TIR-domain signalosomes. Frontiers in Immunology, 12 784484, 1-10. doi: 10.3389/fimmu.2021.784484

Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection

Sasaki, Yo, Zhu, Jian, Shi, Yun, Gu, Weixi, Kobe, Bostjan, Ve, Thomas, DiAntonio, Aaron and Milbrandt, Jeffrey (2021). Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Experimental Neurology, 345 113842, 113842. doi: 10.1016/j.expneurol.2021.113842

Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets

Chua, Sheena M. H., Wizrah, Maha S. I., Luo, Zhenyao, Lim, Bryan Y. J., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2021). Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets. Journal of Biological Chemistry, 297 (4) 101091. doi: 10.1016/j.jbc.2021.101091

Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing

Gu, Weixi, Luo, Zhenyao, Vonrhein, Clemens, Jia, Xinying, Ve, Thomas, Nanson, Jeffrey D. and Kobe, Bostjan (2021). Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing. Acta Crystallographica. Section F: Structural Biology Communications, 77 (10), 364-373. doi: 10.1107/s2053230x21006786

Conformation of the solute-binding protein AdcAII influences zinc uptake in Streptococcus pneumoniae

Župan, Marina L., Luo, Zhenyao, Ganio, Katherine, Pederick, Victoria G., Neville, Stephanie L., Deplazes, Evelyne, Kobe, Boštjan and McDevitt, Christopher A. (2021). Conformation of the solute-binding protein AdcAII influences zinc uptake in Streptococcus pneumoniae. Frontiers in Cellular and Infection Microbiology, 11 729981, 1-15. doi: 10.3389/fcimb.2021.729981

A novel NAD signaling mechanism in axon degeneration and its relationship to innate immunity

Hopkins, Eleanor L., Gu, Weixi, Kobe, Bostjan and Coleman, Michael P. (2021). A novel NAD signaling mechanism in axon degeneration and its relationship to innate immunity. Frontiers in Molecular Biosciences, 8 703532, 1-16. doi: 10.3389/fmolb.2021.703532

The crystal structure of SnTox3 from the necrotrophic fungus Parastagonospora nodorum reveals a unique effector fold and provides insight into Snn3 recognition and pro‐domain protease processing of fungal effectors

Outram, Megan A., Sung, Yi‐Chang, Yu, Daniel, Dagvadorj, Bayantes, Rima, Sharmin A., Jones, David A., Ericsson, Daniel J., Sperschneider, Jana, Solomon, Peter S., Kobe, Bostjan and Williams, Simon J. (2021). The crystal structure of SnTox3 from the necrotrophic fungus Parastagonospora nodorum reveals a unique effector fold and provides insight into Snn3 recognition and pro‐domain protease processing of fungal effectors. New Phytologist, 231 (6) nph.17516, 1-15. doi: 10.1111/nph.17516

Defective embryo and meristems genes are required for cell division and gamete viability in Arabidopsis

Lee, Chin Hong, Hawker, Nathaniel P., Peters, Jonathan R., Lonhienne, Thierry G. A., Gursanscky, Nial R., Matthew, Louisa, Brosnan, Christopher A., Mann, Christopher W. G., Cromer, Laurence, Taochy, Christelle, Ngo, Quy A., Sundaresan, Venkatesan, Schenk, Peer M., Kobe, Bostjan, Borges, Filipe, Mercier, Raphael, Bowman, John L. and Carroll, Bernard J. (2021). Defective embryo and meristems genes are required for cell division and gamete viability in Arabidopsis. PL o S Genetics, 17 (5) e1009561, 1-31. doi: 10.1371/journal.pgen.1009561

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

Clabbers, Max T. B., Holmes, Susannah, Muusse, Timothy W., Vajjhala, Parimala R., Thygesen, Sara J., Malde, Alpeshkumar K., Hunter, Dominic J. B., Croll, Tristan I., Flueckiger, Leonie, Nanson, Jeffrey D., Rahaman, Md. Habibur, Aquila, Andrew, Hunter, Mark S., Liang, Mengning, Yoon, Chun Hong, Zhao, Jingjing, Zatsepin, Nadia A., Abbey, Brian, Sierecki, Emma, Gambin, Yann, Stacey, Katryn J., Darmanin, Connie, Kobe, Bostjan, Xu, Hongyi and Ve, Thomas (2021). MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography. Nature Communications, 12 (1) 2578, 1-14. doi: 10.1038/s41467-021-22590-6

PR1‐mediated defence via C‐terminal peptide release is targeted by a fungal pathogen effector

Sung, Yi‐Chang, Outram, Megan A., Breen, Susan, Wang, Chen, Dagvadorj, Bayantes, Winterberg, Britta, Kobe, Bostjan, Williams, Simon J. and Solomon, Peter S. (2021). PR1‐mediated defence via C‐terminal peptide release is targeted by a fungal pathogen effector. New Phytologist, 229 (6), 3467-3480. doi: 10.1111/nph.17128

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron and Ve, Thomas (2021). SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration. Neuron, 109 (7), 1-19. doi: 10.1016/j.neuron.2021.02.009

A proteome-wide immunoinformatics tool to accelerate T-cell epitope discovery and vaccine design in the context of emerging infectious diseases: an ethnicity-oriented approach

Oyarzun, Patricio, Kashyap, Manju, Fica, Victor, Salas-Burgos, Alexis, Gonzalez-Galarza, Faviel F., McCabe, Antony, Jones, Andrew R., Middleton, Derek and Kobe, Bostjan (2021). A proteome-wide immunoinformatics tool to accelerate T-cell epitope discovery and vaccine design in the context of emerging infectious diseases: an ethnicity-oriented approach. Frontiers in Immunology, 12 598778, 1-25. doi: 10.3389/fimmu.2021.598778

A trap-door mechanism for zinc acquisition by Streptococcus pneumoniae AdcA

Luo, Zhenyao, Morey, Jacqueline R., Deplazes, Evelyne, Motygullina, Alina, Tan, Aimee, Ganio, Katherine, Neville, Stephanie L., Eleftheriadis, Nikolaos, Isselstein, Michael, Pederick, Victoria G., Paton, James C., Cordes, Thorben, Harmer, Jeffrey R., Kobe, Bostjan and McDevitt, Christopher A. (2021). A trap-door mechanism for zinc acquisition by Streptococcus pneumoniae AdcA. mBio, 12 (1) e01958-20, 1-14. doi: 10.1128/mBio.01958-20

Active site architecture reveals coordination sphere flexibility and specificity determinants in a group of closely related molybdoenzymes

Struwe, Michel A., Kalimuthu, Palraj, Luo, Zhenyao, Zhong, Qifeng, Ellis, Daniel, Yang, Jing, Khadanand, K.C., Harmer, Jeffrey R., Kirk, Martin L., McEwan, Alastair G., Clement, Bernd, Bernhardt, Paul V., Kobe, Bostjan and Kappler, Ulrike (2021). Active site architecture reveals coordination sphere flexibility and specificity determinants in a group of closely related molybdoenzymes. Journal of Biological Chemistry, 296 100672, 1-16. doi: 10.1016/j.jbc.2021.100672

Molybdenum enzymes and how they support virulence in pathogenic bacteria

Zhong, Qifeng, Kobe, Bostjan and Kappler, Ulrike (2020). Molybdenum enzymes and how they support virulence in pathogenic bacteria. Frontiers in Microbiology, 11 615860, 1-23. doi: 10.3389/fmicb.2020.615860

Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines

Sun, Chenghai, Luo, Zhenyao, Zhang, Wenlu, Tian, Wenya, Peng, Haidong, Lin, Zhi, Deng, Zixin, Kobe, Bostjan, Jia, Xinying and Qu, Xudong (2020). Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines. Nature Communications, 11 (1) 6251, 1-10. doi: 10.1038/s41467-020-20022-5

Vaccinia virus immunomodulator A46: destructive interactions with MAL and MyD88 shown by negative-stain electron microscopy

Azar, Daniel F., Haas, Meryl, Fedosyuk, Sofiya, Rahaman, Md. Habibur, Hedger, Andrew, Kobe, Bostjan and Skern, Tim (2020). Vaccinia virus immunomodulator A46: destructive interactions with MAL and MyD88 shown by negative-stain electron microscopy. Structure, 28 (12), 1271-1287.e5. doi: 10.1016/j.str.2020.09.007

Targeting multiple epitopes on the spike protein: a new hope for COVID-19 antibody therapy

Sun, Yeping, Kobe, Bostjan and Qi, Jianxun (2020). Targeting multiple epitopes on the spike protein: a new hope for COVID-19 antibody therapy. Signal Transduction and Targeted Therapy, 5 (1) 208, 208. doi: 10.1038/s41392-020-00320-6

Comprehensive analysis of IncC plasmid conjugation identifies a crucial role for the transcriptional regulator AcaB

Hancock, Steven J., Phan, Minh-Duy, Luo, Zhenyao, Lo, Alvin W., Peters, Kate M., Nhu, Nguyen Thi Khanh, Forde, Brian M., Whitfield, Jason, Yang, Ji, Strugnell, Richard A., Paterson, David L., Walsh, Timothy R., Kobe, Bostjan, Beatson, Scott A. and Schembri, Mark A. (2020). Comprehensive analysis of IncC plasmid conjugation identifies a crucial role for the transcriptional regulator AcaB. Nature Microbiology, 5 (11), 1340-1348. doi: 10.1038/s41564-020-0775-0

All major cholesterol-dependent cytolysins use glycans as cellular receptors

Shewell, Lucy K., Day, Christopher J., Jen, Freda E.-C., Haselhorst, Thomas, Atack, John M., Reijneveld, Josephine F., Everest-Dass, Arun, James, David B. A., Boguslawski, Kristina M., Brouwer, Stephan, Gillen, Christine M., Luo, Zhenyao, Kobe, Bostjan, Nizet, Victor, von Itzstein, Mark, Walker, Mark J., Paton, Adrienne W., Paton, James C., Torres, Victor J. and Jennings, Michael P. (2020). All major cholesterol-dependent cytolysins use glycans as cellular receptors. Science Advances, 6 (21) EAAZ4926, eaaz4926. doi: 10.1126/sciadv.aaz4926

Evolutionary model of protein secondary structure capable of revealing new biological relationships

Lai, Jhih‐Siang, Rost, Burkhard, Kobe, Bostjan and Bodén, Mikael (2020). Evolutionary model of protein secondary structure capable of revealing new biological relationships. Proteins: Structure, Function, and Bioinformatics, 88 (9) prot.25898, 1251-1259. doi: 10.1002/prot.25898

The structure and metal binding properties of Chlamydia trachomatis YtgA

Luo, Zhenyao, Neville, Stephanie L., Campbell, Rebecca, Morey, Jacqueline R., Menon, Shruti, Thomas, Mark, Eijkelkamp, Bart A., Ween, Miranda P., Huston, Wilhelmina M., Kobe, Bostjan and McDevitt, Christopher A. (2019). The structure and metal binding properties of Chlamydia trachomatis YtgA. Journal of Bacteriology, 202 (1) e00580. doi: 10.1128/jb.00580-19

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

Horsefield, Shane, Burdett, Hayden, Zhang, Xiaoxiao, Manik, Mohammad K., Shi, Yun, Chen, Jian, Qi, Tiancong, Gilley, Jonathan, Lai, Jhih-Siang, Rank, Maxwell X., Casey, Lachlan W., Gu, Weixi, Ericsson, Daniel J., Foley, Gabriel, Hughes, Robert O., Bosanac, Todd, von Itzstein, Mark, Rathjen, John P., Nanson, Jeffrey D., Boden, Mikael, Dry, Ian B., Williams, Simon J., Staskawicz, Brian J., Coleman, Michael P., Ve, Thomas, Dodds, Peter N. and Kobe, Bostjan (2019). NAD+ cleavage activity by animal and plant TIR domains in cell death pathways. Science, 365 (6455), 793-799. doi: 10.1126/science.aax1911

The plant “resistosome”: structural insights into immune signaling

Burdett, Hayden, Bentham, Adam R., Williams, Simon J., Dodds, Peter N., Anderson, Peter A., Banfield, Mark J. and Kobe, Bostjan (2019). The plant “resistosome”: structural insights into immune signaling. Cell Host and Microbe, 26 (2), 193-201. doi: 10.1016/j.chom.2019.07.020

Animal NLRs continue to inform plant NLR structure and function

Burdett, Hayden, Kobe, Bostjan and Anderson, Peter A. (2019). Animal NLRs continue to inform plant NLR structure and function. Archives of Biochemistry and Biophysics, 670, 58-68. doi: 10.1016/j.abb.2019.05.001

The single nucleotide polymorphism Mal-D96N mice provide new insights into functionality of Mal in TLR immune responses

Dowling, Jennifer K., Tate, Michelle E., Bourke, Nollaig M., Bitto, Natalie, Lauterbach, Mario A., Cheung, Shane, Ve, Thomas, Kobe, Bostjan, Golenbock, Douglas and Mansell, Ashley (2019). The single nucleotide polymorphism Mal-D96N mice provide new insights into functionality of Mal in TLR immune responses. The Journal of Immunology, 202 (8), ji1800501-2396. doi: 10.4049/jimmunol.1800501

Autoimmunity and effector recognition in Arabidopsis thaliana can be uncoupled by mutations in the RRS1-R immune receptor

Newman, Toby E., Lee, Jungmin, Williams, Simon J., Choi, Sera, Halane, Morgan K., Zhou, Jun, Solomon, Peter, Kobe, Bostjan, Jones, Jonathan D. G., Segonzac, Cécile and Sohn, Kee Hoon (2019). Autoimmunity and effector recognition in Arabidopsis thaliana can be uncoupled by mutations in the RRS1-R immune receptor. New Phytologist, 222 (2), 954-965. doi: 10.1111/nph.15617

Death, TIR, and RHIM: Self-assembling domains involved in innate immunity and cell-death signaling

Nanson, Jeffrey D., Kobe, Bostjan and Ve, Thomas (2019). Death, TIR, and RHIM: Self-assembling domains involved in innate immunity and cell-death signaling. Journal of Leukocyte Biology, 105 (2), 363-375. doi: 10.1002/JLB.MR0318-123R

Structural and functional insights into the modulation of the activity of a flax cytokinin oxidase by flax rust effector AvrL567-A

Wan, Li, Koeck, Markus, Williams, Simon J., Ashton, Anthony R., Lawrence, Gregory J., Sakakibara, Hitoshi, Kojima, Mikiko, Böttcher, Christine, Ericsson, Daniel J., Hardham, Adrienne R., Jones, David A., Ellis, Jeffrey G., Kobe, Bostjan and Dodds, Peter N. (2019). Structural and functional insights into the modulation of the activity of a flax cytokinin oxidase by flax rust effector AvrL567-A. Molecular Plant Pathology, 20 (2), 211-222. doi: 10.1111/mpp.12749

Handling of nutrient copper in the bacterial envelope

Stewart, Louisa J., Thaqi, Denis, Kobe, Bostjan, McEwan, Alastair G., Waldron, Kevin J. and Djoko, Karrera Y. (2019). Handling of nutrient copper in the bacterial envelope. Metallomics, 11 (1), 50-63. doi: 10.1039/c8mt00218e

Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88

O'Carroll, Ailís, Chauvin, Brieuc, Brown, James W.P., Meagher, Ava, Coyle, Joanne, Schill, Jurgen, Bhumkhar, Akshay, Hunter, Dominic J.B., Ve, Thomas, Kobe, Bostjan, Sierecki, Emma and Gambin, Yann (2018). Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88. BMC Biology, 16 (149) 149, 149. doi: 10.1186/s12915-018-0611-7

Megahertz serial crystallography

Wiedorn, Max O., Oberthür, Dominik, Bean, Richard, Schubert, Robin, Werner, Nadine, Abbey, Brian, Aepfelbacher, Martin, Adriano, Luigi, Allahgholi, Aschkan, Al-Qudami, Nasser, Andreasson, Jakob, Aplin, Steve, Awel, Salah, Ayyer, Kartik, Bajt, Saša, Barák, Imrich, Bari, Sadia, Bielecki, Johan, Botha, Sabine, Boukhelef, Djelloul, Brehm, Wolfgang, Brockhauser, Sandor, Cheviakov, Igor, Coleman, Matthew A., Cruz-Mazo, Francisco, Danilevski, Cyril, Darmanin, Connie, Doak, R. Bruce, Domaracky, Martin ... Barty, Anton (2018). Megahertz serial crystallography. Nature Communications, 9 (1) 4025, 4025. doi: 10.1038/s41467-018-06156-7

Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles

Kummari, Lalith K., Butler, Mark S., Furlong, Emily, Blundell, Ross, Nouwens, Amanda, Silva, Alberto B., Kappler, Ulrike, Fraser, James A., Kobe, Bostjan, Cooper, Matthew A. and Robertson, Avril A.B. (2018). Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles. Bioorganic and Medicinal Chemistry, 26 (20), 5408-5419. doi: 10.1016/j.bmc.2018.09.004

Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae

Luo, Zhenyao, Pederick, Victoria G., Paton, James C., McDevitt, Christopher A. and Kobe, Bostjan (2018). Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae. FEBS letters, 592 (13), 2341-2350. doi: 10.1002/1873-3468.13122

Regulation of signaling by cooperative assembly formation in mammalian innate immunity signalosomes by molecular mimics

Nanson, Jeffrey D., Rahaman, Habibur, Ve, Thomas and Kobe, Bostjan (2018). Regulation of signaling by cooperative assembly formation in mammalian innate immunity signalosomes by molecular mimics. Seminars in Cell and Developmental Biology, 99, 96-114. doi: 10.1016/j.semcdb.2018.05.002

Crystal structure and insights into the oligomeric state of UDP-glucose pyrophosphorylase from sugarcane

Cotrim, Camila A., Soares, Jose Sergio M., Kobe, Bostjan and Menossi, Marcelo (2018). Crystal structure and insights into the oligomeric state of UDP-glucose pyrophosphorylase from sugarcane. PloS One, 13 (3) 0193667, 1-13. doi: 10.1371/journal.pone.0193667

An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis

Ryan, Timothy M., Trewhella, Jill, Murphy, James M., Keown, Jeremy R., Casey, Lachlan, Pearce, F. Grant, Goldstone, David C., Chen, Kelan, Luo, Zhenyao, Kobe, Bostjan, McDevitt, Christopher A., Watkin, Serena A., Hawley, Adrian M., Mudie, Stephen T., Boban, Vesna Samardzic and Kirby, Nigel (2018). An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis. Journal of Applied Crystallography, 51 (1), 97-111. doi: 10.1107/S1600576717017101

Structural and functional characterization of a cross-reactive dengue virus neutralizing antibody that recognizes a cryptic epitope

Li, Jie, Watterson, Daniel, Chang, Chiung-Wen, Che, Xiao-Yan, Li, Xiao-Quan, Ericsson, Daniel J., Qiu, Li-Wen, Cai, Jian-Piao, Chen, Jing, Fry, Scott R., Cheung, Stacey T. M., Cooper, Matthew A., Young, Paul R. and Kobe, Bostjan (2018). Structural and functional characterization of a cross-reactive dengue virus neutralizing antibody that recognizes a cryptic epitope. Structure, 26 (1), 51-59. doi: 10.1016/j.str.2017.11.017

DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway

de Barros, Andrea C, Takeda, Agnes A S, Dreyer, Thiago R, Velazquez-Campoy, Adrian, Kobe, Boštjan and Fontes, Marcos R M (2017). DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 87-96. doi: 10.1016/j.biochi.2017.11.013

Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P

Zhang, Xiaoxiao, Farah, Nadya, Rolston, Laura, Ericsson, Daniel J., Catanzariti, Ann-Maree, Bernoux, Maud, Ve, Thomas, Bendak, Katerina, Chen, Chunhong, Mackay, Joel P., Lawrence, Gregory J., Hardham, Adrienne, Ellis, Jeffrey G., Williams, Simon J., Dodds, Peter N., Jones, David A. and Kobe, Bostjan (2017). Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P. Molecular Plant Pathology, 19 (5), 1196-1209. doi: 10.1111/mpp.12597

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling

Hughes, Mark M., Lavrencic, Peter, Coll, Rebecca C., Ve, Thomas, Ryan, Dylan G., Williams, Niamh C., Menon, Deepthi, Mansell, Ashley, Board, Philip G., Mobli, Mehdi, Kobe, Bostjan and O'Neill, Luke A. J. (2017). Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling. Proceedings of the National Academy of Sciences, 114 (32), E6480-E6489. doi: 10.1073/pnas.1701868114

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

Ve, Thomas, Vajjhala, Parimala, Hedger, Andrew, Croll, Tristan, DiMaio, Frank, Horsefield, Shane, Yu, Xiong, Lavrencic, Peter, Hassan, Zahid, Morgan, Garry P., Mansell, Ashley, Mobli, Mehdi, O'Carroll, Ailis, Chauvin, Brieuc, Gambin, Yann, Sierecki, Emma, Landsberg, Michael J., Stacey, Katryn, Egelman, Edward H. and Kobe, Bostjan (2017). Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling. Nature Structural and Molecular Biology, 24 (9), 743-751. doi: 10.1038/nsmb.3444

Emerging insights into the functions of pathogenesis-related protein 1

Breen, Susan, Williams, Simon J., Outram, Megan, Kobe, Bostjan and Solomon, Peter S. (2017). Emerging insights into the functions of pathogenesis-related protein 1. Trends in Plant Science, 22 (10), 871-879. doi: 10.1016/j.tplants.2017.06.013

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design

Chitty, Jessica L., Blake, Kirsten L., Blundell, Ross D., Koh, Y. Q. Andre E., Thompson, Merinda, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kappler, Ulrike, Williams, Simon J., Kobe, Bostjan and Fraser, James A. (2017). Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design. Journal of Biological Chemistry, 292 (28), 11829-11839. doi: 10.1074/jbc.M117.787994

The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways

Vajjhala, Parimala R., Ve, Thomas, Bentham, Adam, Stacey, Katryn J. and Kobe, Bostjan (2017). The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways. Molecular Immunology, 86, 23-37. doi: 10.1016/j.molimm.2017.02.012

Towards the structure of the TIR-domain signalosome

Nimma, Surekha, Ve, Thomas, Williams, Simon J. and Kobe, Bostjan (2017). Towards the structure of the TIR-domain signalosome. Current Opinion In Structural Biology, 43, 122-130. doi: 10.1016/j.sbi.2016.12.014

GMP synthase is required for virulence factor production and infection by cryptococcus neoformans

Chitty, Jessica L., Tatzenko, Tayla L. , Williams, Simon J., Koh, Y. Q. Andre E., Corfield, Elizabeth C., Butler, Mark S., Robertson, Avril A. B., Cooper, Matthew A., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2017). GMP synthase is required for virulence factor production and infection by cryptococcus neoformans. Journal of Biological Chemistry, 292 (7), 3049-3059. doi: 10.1074/jbc.M116.767533

A non-uniform sampling approach enables studies of dilute and unstable proteins

Miljenović, Tomas, Jia, Xinying, Lavrencic, Peter, Kobe, Bostjan and Mobli, Mehdi (2017). A non-uniform sampling approach enables studies of dilute and unstable proteins. Journal of Biomolecular NMR, 68 (2), 1-9. doi: 10.1007/s10858-017-0091-z

PhosphoPICK-SNP: quantifying the effect of amino acid variants on protein phosphorylation

Patrick, Ralph, Kobe, Bostjan, Lê Cao, Kim-Anh and Bodén, Mikael (2017). PhosphoPICK-SNP: quantifying the effect of amino acid variants on protein phosphorylation. Bioinformatics, 33 (12), 1773-1781. doi: 10.1093/bioinformatics/btx072

Multiple functional self-association interfaces in plant TIR domains

Zhang, Xiaoxiao, Bernoux, Maud, Bentham, Adam R., Newman, Toby E., Ve, Thomas, Casey, Lachlan W., Raaymakers, Tom M., Hu, Jian, Croll, Tristan I., Schreiber, Karl J., Staskawicz, Brian J., Anderson, Peter A., Sohn, Kee Hoon, Williams, Simon J., Dodds, Peter N. and Kobe, Bostjan (2017). Multiple functional self-association interfaces in plant TIR domains. Proceedings of the National Academy of Sciences, 114 (10), E2046-E2052. doi: 10.1073/pnas.1621248114

Blood group antigen recognition via the group A Streptococcal M protein mediates host colonization

De Oliveira, David M. P., Hartley-Tassell, Lauren, Everest-Dass, Arun, Day, Christopher J., Dabbs, Rebecca A., Ve, Thomas, Kobe, Bostjan, Nizet, Victor, Packer, Nicolle H., Walker, Mark J., Jennings, Michael P. and Sanderson-Smith, Martina L. (2017). Blood group antigen recognition via the group A Streptococcal M protein mediates host colonization. MBio, 8 (1) e02237-16, e02237-16. doi: 10.1128/mBio.02237-16

Structure and function of the TIR domain from the grape NLR protein RPV1

Williams, Simon J., Yin, Ling, Foley, Gabriel, Casey, Lachlan W., Outram, Megan A., Ericsson, Daniel J., Lu, Jiang, Boden, Mikael, Dry, Ian B. and Kobe, Bostjan (2016). Structure and function of the TIR domain from the grape NLR protein RPV1. Frontiers in Plant Science, 7 (DECEMBER2016) 1850, 1850. doi: 10.3389/fpls.2016.01850

The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins

Casey, Lachlan W., Lavrencic, Peter, Bentham, Adam R., Cesari, Stella, Ericsson, Daniel J., Croll, Tristan, Turk, Dušan, Anderson, Peter A., Mark, Alan E., Dodds, Peter N., Mobli, Mehdi, Kobe, Bostjan and Williams, Simon J. (2016). The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins. Proceedings of the National Academy of Sciences, 113 (45), 12856-12861. doi: 10.1073/pnas.1609922113

Prediction of kinase-specific phosphorylation sites through an integrative model of protein context and sequence

Patrick, Ralph, Horin, Coralie, Kobe, Bostjan, Cao, Kim-Anh Le and Bodén, Mikael (2016). Prediction of kinase-specific phosphorylation sites through an integrative model of protein context and sequence. Biochimica et Biophysica Acta, 1864 (11), 1599-1608. doi: 10.1016/j.bbapap.2016.08.001

Wheat PR-1 proteins are targeted by necrotrophic pathogen effector proteins

Breen, Susan, Williams, Simon J., Winterberg, Britta, Kobe, Bostjan and Solomon, Peter S. (2016). Wheat PR-1 proteins are targeted by necrotrophic pathogen effector proteins. Plant Journal, 88 (1), 13-25. doi: 10.1111/tpj.13228

Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformans

Blundell, Ross D., Williams, Simon J., Arras, Samantha D. M., Chitty, Jessica L., Blake, Kirsten L., Ericsson, Daniel J., Tibrewal, Nidhi, Rohr, Jurgen, Koh, Y. Q. Andre, Kappler, Ulrike, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kobe, Bostjan and Fraser, James A. (2016). Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformans. ACS Infectious Diseases, 2 (9), 651-663. doi: 10.1021/acsinfecdis.6b00121

Animal NLRs provide structural insights into plant NLR function

Bentham, Adam, Burdett, Hayden, Anderson, Peter A., Williams, Simon J. and Kobe, Bostjan (2016). Animal NLRs provide structural insights into plant NLR function. Annals of Botany, 119 (5), 689-702. doi: 10.1093/aob/mcw171

Multiple domain associations within the Arabidopsis immune receptor RPP1 regulate the activation of programmed cell death

Schreiber, Karl J., Bentham, Adam, Williams, Simon J., Kobe, Bostjan and Staskawicz, Brian J. (2016). Multiple domain associations within the Arabidopsis immune receptor RPP1 regulate the activation of programmed cell death. PLoS Pathogens, 12 (7) e1005769, e1005769. doi: 10.1371/journal.ppat.1005769

Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region

Couñago, Rafael M., Chen, Nathan H., Chang, Chiung-Wen, Djoko, Karrera Y., McEwan, Alastair G. and Kobe, Bostjan (2016). Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region. Nucleic Acids Research, 44 (14), 6981-6993. doi: 10.1093/nar/gkw543

Structural and calorimetric studies demonstrate that Xeroderma pigmentosum type G (XPG) can be imported to the nucleus by a classical nuclear import pathway via a monopartite NLS sequence

de Barros, Andrea C., Takeda, Agnes A.S., Dreyer, Thiago R., Velazquez-Campoy, Adrian, Kobe, Bostjan and Fontes, Marcos R.M. (2016). Structural and calorimetric studies demonstrate that Xeroderma pigmentosum type G (XPG) can be imported to the nucleus by a classical nuclear import pathway via a monopartite NLS sequence. Journal of Molecular Biology, 428 (10), 2120-2131. doi: 10.1016/j.jmb.2016.01.019

Structural biology and regulation of protein import into the nucleus

Christie, Mary, Chang, Chiung-Wen, Róna, Gergely, Smith, Kate M., Stewart, Alastair G, Takeda, Agnes A. S., Fontes, Marcos R. M., Stewart, Murray, Vértessy, Beáta G., Forwood, Jade K. and Kobe, Bostjan (2016). Structural biology and regulation of protein import into the nucleus. Journal of Molecular Biology, 428 (10), 2060-2090. doi: 10.1016/j.jmb.2015.10.023

Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-alpha (vol 14, pg 1144, 2013)

Chang, Chiung-Wen, Counago, Rafael Miguez, Williams, Simon J., Boden, Mikael and Kobe, Bostjan (2016). Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-alpha (vol 14, pg 1144, 2013). Traffic, 17 (6), 704-704. doi: 10.1111/tra.12395

TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

Ullah, M. Obayed, Sweet, Matthew J., Mansell, Ashley, Kellie, Stuart and Kobe, Bostjan (2016). TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target. Journal of Leukocyte Biology, 100 (1), 27-45. doi: 10.1189/jlb.2RI1115-531R

Protein crystal screening and characterization for serial femtosecond nanocrystallography

Darmanin, Connie, Strachan, Jamie, Adda, Christopher G., Ve, Thomas, Kobe, Bostjan and Abbey, Brian (2016). Protein crystal screening and characterization for serial femtosecond nanocrystallography. Scientific Reports, 6 (1) 25345, 25345.1-25345.8. doi: 10.1038/srep25345

Production of small cysteine-rich effector proteins in Escherichia coli for structural and functional studies

Zhang, Xiaoxiao, Nguyen, Neal, Breen, Susan, Outram, Megan A., Dodds, Peter N., Kobe, Bostjan, Solomon, Peter S. and Williams, Simon J. (2016). Production of small cysteine-rich effector proteins in Escherichia coli for structural and functional studies. Molecular Plant Pathology, 18 (1), 141-151. doi: 10.1111/mpp.12385

Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery

You, Lv, Kandale, Ajit, Wun, Shun Jie, McGeary, Ross P., Williams, Simon J., Kobe, Bostjan, Sieber, Volker, Schembri, Mark A., Schenk, Gerhard and Guddat, Luke W. (2016). Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery. Febs Journal, 283 (7), 1184-1196. doi: 10.1111/febs.13672

Comparative analysis of the flax immune receptors L6 and L7 suggests an equilibrium-based switch activation model

Bernoux, Maud, Burdett, Hayden, Williams, Simon J., Zhang, Xiaoxiao, Chen, Chunhong, Newell, Kim, Lawrence, Gregory J., Kobe, Bostjan, Ellis, Jeffrey G., Anderson, Peter A. and Dodds, Peter N. (2016). Comparative analysis of the flax immune receptors L6 and L7 suggests an equilibrium-based switch activation model. Plant Cell, 28 (1), 146-159. doi: 10.1105/tpc.15.00303

Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and production

Oyarzun, Patricio and Kobe, Bostjan (2016). Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and production. Human Vaccines and Immunotherapeutics, 12 (3), 763-767. doi: 10.1080/21645515.2015.1094595

Characterizing the conformational dynamics of metal-free PsaA usingmolecular dynamics simulations and electron paramagnetic resonance spectroscopy

Deplazes, Evelyne, Begg, Stephanie L., van Wonderen, Jessica H., Campbell, Rebecca, Kobe, Bostjan, Paton, James C., MacMillan, Fraser, McDevitt, Christopher A. and O'Mara, Megan L. (2015). Characterizing the conformational dynamics of metal-free PsaA usingmolecular dynamics simulations and electron paramagnetic resonance spectroscopy. Biophysical Chemistry, 207, 51-60. doi: 10.1016/j.bpc.2015.08.004

Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA

Luo, Zhenyao, Morey, Jacqueline R., McDevitt, Christopher A. and Kobe, Bostjan (2015). Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA. Acta Crystallographica: Section F Structural Biology Communications, 71 (12), 1459-1464. doi: 10.1107/S2053230X15021330

Computer-aided design of T-cell epitope-based vaccines: addressing population coverage

Oyarzun, P. and Kobe, B. (2015). Computer-aided design of T-cell epitope-based vaccines: addressing population coverage. International Journal of Immunogenetics, 42 (5), 313-321. doi: 10.1111/iji.12214

Structural and biochemical analysis of a single amino-acid mutant of WzzBSF that alters Lipopolysaccharide O-antigen chain length in Shigella flexneri

Chang, Chiung-Wen, Tran, Elizabeth N. H., Ericsson, Daniel J., Casey, Lachlan W., Lonhienne, Thierry, Benning, Friederike, Morona, Renato and Kobe, Bostjan (2015). Structural and biochemical analysis of a single amino-acid mutant of WzzBSF that alters Lipopolysaccharide O-antigen chain length in Shigella flexneri. PLoS One, 10 (9) e0138266, e0138266. doi: 10.1371/journal.pone.0138266

Fusion-protein-assisted protein crystallization

Kobe, Bostjan, Ve, Thomas and Williams, Simon J. (2015). Fusion-protein-assisted protein crystallization. Acta Crystallographica. Section F Structural Biology Communications, 71 (7), 861-869. doi: 10.1107/S2053230X15011061

Stability of the octameric structure affects plasminogen-binding capacity of Streptococcal enolase

Cork, Amanda J., Ericsson, Daniel J., Law, Ruby H. P., Casey, Lachlan W., Valkov, Eugene, Bertozzi, Carlo, Stamp, Anna, Jovcevski, Blagojce, Aquilina, J. Andrew, Whisstock, James C., Walker, Mark J. and Kobe, Bostjan (2015). Stability of the octameric structure affects plasminogen-binding capacity of Streptococcal enolase. PLoS One, 10 (3) e0121764, 1-18. doi: 10.1371/journal.pone.0121764

Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae

Begg, Stephanie L., Eijkelkamp, Bart A., Luo, Zhenyao, Couñago, Rafael M., Morey, Jacqueline R., Maher, Megan J., Ong, Cheryl-lynn Y., McEwan, Alastair G., Kobe, Bostjan, O'Mara, Megan L., Paton, James C. and McDevitt, Christopher A. (2015). Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae. Nature Communications, 6 (6418) 6418, 1-11. doi: 10.1038/ncomms7418

A linker strategy for the production and crystallization of Toll/interleukin-1 receptor/resistance protein domain complexes

Williams, Simon J., Ve, Thomas and Kobe, Bostjan (2015). A linker strategy for the production and crystallization of Toll/interleukin-1 receptor/resistance protein domain complexes. Protein Engineering, Design and Selection, 28 (5), 137-145. doi: 10.1093/protein/gzv013

Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach

Bajaj, Megha, Mamidyala, Sreeman K., Zuegg, Johannes, Begg, Stephanie L., Ween, Miranda P., Luo, Zhenyao, Huang, Johnny Xiao, McEwan, Alastair G., Kobe, Bostjan, Paton, James C., McDevitt, Christopher A. and Cooper, Matthew A. (2015). Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology, 10 (6), 1511-1520. doi: 10.1021/cb501032x

TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation.

Thakar, Nilay Y., Ovchinnikov, Dmitry A., Hastie, Marcus L., Kobe, Bostjan, Gorman, Jeffrey J. and Wolvetang, Ernst J. (2015). TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation.. Molecular Biology of the Cell, 26 (5), 993-1006. doi: 10.1091/mbc.E14-08-1290

A bioinformatics tool for epitope-based vaccine design that accounts for human ethnic diversity: Application to emerging infectious diseases.

Oyarzun, Patricio, Ellis, Jonathan J., Gonzalez-Galarza, Faviel F., Jones, Andrew R, Middleton, Derek, Boden, Mikael and Kobe, Bostjan (2015). A bioinformatics tool for epitope-based vaccine design that accounts for human ethnic diversity: Application to emerging infectious diseases.. Vaccine, 33 (10), 1267-1273. doi: 10.1016/j.vaccine.2015.01.040

Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains.

Ve, Thomas, Williams, Simon J. and Kobe, Bostjan (2014). Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains.. Apoptosis, 20 (2), 250-261. doi: 10.1007/s10495-014-1064-2

Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation

Roona, Gergely, Borsos, Mate, Ellis, Jonathan J., Mehdi, Ahmed M., Christie, Mary, Koornyei, Zsuzsanna, Neubrandt, Mate, Tooth, Judit, Bozooky, Zoltan, Buday, Laszlo, Madaraasz, Emilia, Bodaen, Mikael, Kobe, Bostjan and Veertessy, Beata G. (2014). Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation. Cell Cycle, 13 (22), 3551-3564. doi: 10.4161/15384101.2014.960740

Diversity and variability of NOD-like receptors in fungi

Dyrka, Witold, Lamacchia, Marina, Durrens, Pascal, Kobe, Bostjan, Daskalov, Asen, Paoletti, Matthieu, Sherman, David J. and Saupe, Sven J. (2014). Diversity and variability of NOD-like receptors in fungi. Genome Biology and Evolution, 6 (12), 3137-3158. doi: 10.1093/gbe/evu251

Recombinant production of functional full-length and truncated human TRAM/TICAM-2 adaptor protein involved in toll-like receptor and interferon signaling

Obayed Ullah, M., Valkov, Eugene, Ve, Thomas, Williams, Simon, Mas, Caroline, Mansell, Ashley and Kobe, Bostjan (2014). Recombinant production of functional full-length and truncated human TRAM/TICAM-2 adaptor protein involved in toll-like receptor and interferon signaling. Protein Expression and Purification, 106, 31-40. doi: 10.1016/j.pep.2014.09.019

PhosphoPICK: modelling cellular context to map kinase-substrate phosphorylation events

Patrick, Ralph, Lê Cao, Kim-Anh, Kobe, Bostjan and Bodén, Mikael (2014). PhosphoPICK: modelling cellular context to map kinase-substrate phosphorylation events. Bioinformatics, 31 (3), 382-389. doi: 10.1093/bioinformatics/btu663

Factors influencing nucleo-cytoplasmic trafficking: which matter? Response to Alvisi & Jans' comment on Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights

Róna, Gergely, Borsos, Máté, Kobe, Bostjan and Vértessy, Beáta G. (2014). Factors influencing nucleo-cytoplasmic trafficking: which matter? Response to Alvisi & Jans' comment on Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights. Acta Crystallographica. Section D: Biological Crystallography, 70 (10), 2777-2778. doi: 10.1107/S1399004714020501

The nuclear immune receptor RPS4 is required for RRS1SLH1-dependent constitutive defense activation in Arabidopsis thaliana.

Sohn, Kee Hoon, Segonzac, Cecile, Rallapalli, Ghanasyam, Sarris, Panagiotis F., Woo, Joo Yong, Williams, Simon J., Newman, Toby E., Paek, Kyung Hee, Kobe, Bostjan and Jones, Jonathan D. G. (2014). The nuclear immune receptor RPS4 is required for RRS1SLH1-dependent constitutive defense activation in Arabidopsis thaliana.. PLoS Genetics, 10 (10), e1004655. doi: 10.1371/journal.pgen.1004655

The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4

Verstak, Brett, Stack, Julianne, Ve, Thomas, Mangan, Matthew, Hjerrild, Kathryn, Jeon, Jannah, Stahl, Rainer, Latz, Eicke, Gay, Nick, Kobe, Bostjan, Bowie, Andrew G. and Mansell, Ashley (2014). The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4. Journal of Leukocyte Biology, 96 (3), 427-436. doi: 10.1189/jlb.2A0913-487R

Structural basis for assembly and function of a heterodimeric plant immune receptor

Williams, Simon J., Sohn, Kee Hoon, Wan, Li, Bernoux, Maud, Sarris, Panagiotis, Segonzac, Cecile, Ve, Thomas, Ma, Yan, Saucet, Simon B., Ericsson, Daniel J., Casey, Lachlan W., Lonhienne, Thierry, Winzor, Donald J., Zhang, Xiaoxiao, Coerdt, Anne, Parker, Jane E., Dodds, Peter N., Kobe, Bostjan and Jones, Jonathan D. G. (2014). Structural basis for assembly and function of a heterodimeric plant immune receptor. Science, 344 (6181), 299-303. doi: 10.1126/science.1247357

Structural basis of interaction of bipartite nuclear localization signal from Agrobacterium VirD2 with rice importin-alpha

Chang, Chiung-Wen, Williams, Simon J., Couñago, Rafael Miguez and Kobe, Bostjan (2014). Structural basis of interaction of bipartite nuclear localization signal from Agrobacterium VirD2 with rice importin-alpha. Molecular Plant, Advance Access (6), 1-10. doi: 10.1093/mp/ssu014

AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae

Plumptre, Charles D., Eijkelkamp, Bart A., Morey, Jacqueline R., Behr, Felix, Couñago, Rafael M., Ogunniyi, Abiodun D., Kobe, Bostjan, O'Mara, Megan L., Paton, James C. and McDevitt, Christopher A. (2014). AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae. Molecular Microbiology, 91 (4), 834–851-834–851. doi: 10.1111/mmi.12504

Imperfect coordination chemistry facilitates metal ion release in the Psa permease

Couñago, Rafael M., Ween, Miranda P., Begg, Stephanie L., Bajaj, Megha, Zuegg, Johannes, O'Mara, Megan L., Cooper, Matthew A., McEwan, Alastair G., Paton, James C., Kobe, Bostjan and McDevitt, Christopher A. (2014). Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 10 (1), 35-41. doi: 10.1038/nCHeMBIO.1382

International Year of Crystallography

Batten, Stuart R., Kobe, Bostjan and Guddat, Luke (2014). International Year of Crystallography. Australian Journal of Chemistry, 67 (12), 1718-1719. doi: 10.1071/CH14557

Small-Angle X-Ray Scattering for the Discerning Macromolecular Crystallographer

Casey, Lachlan W., Mark, Alan E. and Kobe, Bostjan (2014). Small-Angle X-Ray Scattering for the Discerning Macromolecular Crystallographer. Australian Journal of Chemistry, 67 (12), 1786-1792. doi: 10.1071/CH14396

Structural characterisation of the nuclear import receptor importin alpha in complex with the bipartite NLS of Prp20

Roman, Noelia, Christie, Mary, Swarbrick, Crystall M. D., Kobe, Bostjan and Forwood, Jade K. (2013). Structural characterisation of the nuclear import receptor importin alpha in complex with the bipartite NLS of Prp20. PLoS One, 8 (12) e82038, e82038.1-e82038.6. doi: 10.1371/journal.pone.0082038

Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: Structural and mechanistic insights

Rona, G., Marfori, M., Borsos, M., Scheer, I., Takacs, E., Toth, J., Babos, F., Magyar, A., Erdei, A., Bozoky, Z., Buday, L., Kobe, B. and Vertessy, B.G. (2013). Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: Structural and mechanistic insights. Acta Crystallographica Section D: Biological Crystallography, 69 (12), 2495-2505. doi: 10.1107/S0907444913023354

The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins

Ullah, M. Obayed, Ve, Thomas, Mangan, Matthew, Alaidarous, Mohammed, Sweet, Matthew J., Mansell, Ashley and Kobe, Bostjan (2013). The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins. Acta Crystallographica Section D: Biological Crystallography, 69 (12), 2420-2430. doi: 10.1107/S0907444913022385

Mechanism of bacterial interference with TLR4 signaling by Brucella TIR-domain-containing protein TcpB

Alaidarous, Mohammed Abdullah, Ve, Thomas, Casey, Lachlan, Valkov, Eugene, Ericsson, Daniel, Obayed, Ullah, M., Schembri, Mark A., Mansell, Ashley, Sweet, Matthew J. and Kobe, Bostjan (2013). Mechanism of bacterial interference with TLR4 signaling by Brucella TIR-domain-containing protein TcpB. Journal of Biological Chemistry, 289 (2), 654-668. doi: 10.1074/jbc.M113.523274

Crystallization and preliminary X-ray diffraction analyses of the TIR domains of three TIR-NB-LRR proteins that are involved in disease resistance in Arabidopsis thaliana

Wan, Li, Zhang, Xiaoxiao, Williams, Simon J., Ve, Thomas, Bernoux, Maud, Sohn, Kee Hoon, Jones, Jonathan D. G., Dodds, Peter N. and Kobe, Bostjan (2013). Crystallization and preliminary X-ray diffraction analyses of the TIR domains of three TIR-NB-LRR proteins that are involved in disease resistance in Arabidopsis thaliana. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (11), 1275-1280. doi: 10.1107/S1744309113026614

Distinctive conformation of minor site-specific nuclear localization signals bound to importin-α

Chang, Chiung-Wen, Counago, Rafael Miguez, Williams, Simon J., Boden, Mikael and Kobe, Bostjan (2013). Distinctive conformation of minor site-specific nuclear localization signals bound to importin-α. Traffic, 14 (11), 1144-1154. doi: 10.1111/tra.12098

Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of the TIR domain from the Brucella melitensis TIR-domain-containing protein TcpB

Alaidarous, Mohammed, Ve, Thomas, Ullah, M. Obayed, Valkov, Eugene, Mansell, Ashley, Schembri, Mark A., Sweet, Matthew J. and Kobe, Bostjan (2013). Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of the TIR domain from the Brucella melitensis TIR-domain-containing protein TcpB. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (10), 1167-1170. doi: 10.1107/S1744309113024408

Crystallization and preliminary X-ray diffraction analysis of the flax cytokinin oxidase LuCKX1.1

Wan, Li, Williams, Simon J., Zhang, Xiaoxiao, Ericsson, Daniel J., Koeck, Markus, Dodds, Peter N., Ellis, Jeffrey G. and Kobe, Bostjan (2013). Crystallization and preliminary X-ray diffraction analysis of the flax cytokinin oxidase LuCKX1.1. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (10), 1094-1096. doi: 10.1107/S1744309113023142

Structures of the flax-rust effector AvrM reveal insights into the molecular basis of plant-cell entry and effector-triggered immunity

Ve, Thomas, Williams, Simon J., Catanzariti, Ann-Maree, Rafiqi, Maryam, Rahman, Motiur, Ellis, Jeffrey G., Hardham, Adrienne R., Jones, David A., Anderson, Peter A., Dodds, Peter N. and Kobe, Bostjan (2013). Structures of the flax-rust effector AvrM reveal insights into the molecular basis of plant-cell entry and effector-triggered immunity. Proceedings of the National Academy of Sciences of the United States of America, 110 (43), 17594-17599. doi: 10.1073/pnas.1307614110

Purification, crystallization and preliminary X-ray analysis of adenylosuccinate synthetase from the fungal pathogen Cryptococcus neoformans

Blundell, Ross D., Williams, Simon J., Morrow, Carl A., Ericsson, Daniel J., Kobe, Bostjan and Fraser, James A. (2013). Purification, crystallization and preliminary X-ray analysis of adenylosuccinate synthetase from the fungal pathogen Cryptococcus neoformans. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (Pt. 9), 1033-1036. doi: 10.1107/S1744309113021921

Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus

Henningham, Anna, Ericsson, Daniel J., Langer, Karla, Casey, Lachlan W., Jovcevski, Blagojce, Singh Chhatwal, G., Aquilina, J. Andrew, Batzloff, Michael R., Kobe, Bostjan and Walker, Mark J. (2013). Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus. mBio, 4 (4) e00509-13. doi: 10.1128/mBio.00509-13

Crystallization and X-ray diffraction analysis of the N-terminal domain of the Toll-like receptor signalling adaptor protein TRIF/TICAM-1

Ullah, M. Obayed, Ve, Thomas, Dkhar, Jameris, Alaidarous, Mohammed, Ericsson, Daniel J., Sweet, Matthew J., Mansell, Ashley and Kobe, Bostjan (2013). Crystallization and X-ray diffraction analysis of the N-terminal domain of the Toll-like receptor signalling adaptor protein TRIF/TICAM-1. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (7), 766-770. doi: 10.1107/S174430911301419X

A glutathione-dependent detoxification system is required for formaldehyde resistance and optimal survival of Neisseria meningitidis in biofilms

Chen, Nathan H., Couñago, Rafael M., Djoko, Karrera Y., Jennings, Michael P., Apicella, Michael A., Kobe, Bostjan and McEwan, Alastair G. (2013). A glutathione-dependent detoxification system is required for formaldehyde resistance and optimal survival of Neisseria meningitidis in biofilms. Antioxidants and Redox Signaling, 18 (7), 743-755. doi: 10.1089/ars.2012.4749

PREDIVAC: CD4+T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity

Oyarzun, Patricio, Ellis, Jonathan J., Boden, Mikael and Kobe, Bostjan (2013). PREDIVAC: CD4+T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity. BMC Bioinformatics, 14 (1) 52, 52. doi: 10.1186/1471-2105-14-52

DLocalMotif: a discriminative approach for discovering local motifs in protein sequences

Mehdi, Ahmed M., Sehgal, Muhammad Shoaib B., Kobe, Bostjan, Bailey, Timothy L. and Boden, Mikael (2013). DLocalMotif: a discriminative approach for discovering local motifs in protein sequences. Bioinformatics, 29 (1), 39-46. doi: 10.1093/bioinformatics/bts654

The distribution of different classes of nuclear localization signals (NLSs) in diverse organisms and the utilization of the minor NLS-binding site in plant nuclear import factor importin-α

Chang, Chiung-Wen, Counago, Rafael Miguez, Williams, Simon J., Boden, Mikael and Kobe, Bostjan (2013). The distribution of different classes of nuclear localization signals (NLSs) in diverse organisms and the utilization of the minor NLS-binding site in plant nuclear import factor importin-α. Plant Signaling and Behavior, 8 (10), e25976.1-e25976.6. doi: 10.4161/psb.25976

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized

Chen, Kai-En, Richards, Ayanthi A., Caradoc-Davies, Tom T., Vajjhala, Parimala R., Robin, Gautier, Lua, Linda H. L., Hill, Justine M., Schroder, Kate, Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer (2013). The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. Acta Crystallographica Section D: Biological Crystallography, 69 (5), 774-784. doi: 10.1107/S0907444913001558

Crystal structure of rice importin-alpha and structural basis of its interaction with plant-specific nuclear localization signals

Chang, Chiung-Wen, Counago, Rafael Lemos Miguez, Williams, Simon J., Boden, Mikael and Kobe, Bostjan (2012). Crystal structure of rice importin-alpha and structural basis of its interaction with plant-specific nuclear localization signals. Plant Cell, 24 (12), 5074-5088. doi: 10.1105/tpc.112.104422

Intramolecular interaction influences binding of the flax L5 and L6 resistance proteins to their AvrL567 ligands

Ravensdale, Michael, Bernoux, Maud, Ve, Thomas, Kobe, Bostjan, Thrall, Peter H., Ellis, Jeffrey G. and Dodds, Peter N. (2012). Intramolecular interaction influences binding of the flax L5 and L6 resistance proteins to their AvrL567 ligands. PloS Pathogens, 8 (11) e1003004, e1003004. doi: 10.1371/journal.ppat.1003004

De novo GTP biosynthesis is critical for virulence of the fungal pathogen cryptococcus neoformans

Morrow, Carl A., Valkov, Eugene, Stamp, Anna, Chow, Eve W. L., Lee, I. Russel, Wronski, Ania, Williams, Simon J., Hill, Justine M., Djordjevic, Julianne T., Kappler, Ulrke, Kobe, Bostjan and Fraser, James A. (2012). De novo GTP biosynthesis is critical for virulence of the fungal pathogen cryptococcus neoformans. PLoS Pathogens, 8 (10) e1002957, e1002957. doi: 10.1371/journal.ppat.1002957

Adaptors in toll-like receptor signaling and their potential as therapeutic targets

Ve, Thomas, Gay, Nicholas J., Mansell, Ashley, Kobe, Bostjan and Kellie, Stuart (2012). Adaptors in toll-like receptor signaling and their potential as therapeutic targets. Current Drug Targets, 13 (11), 1360-1374. doi: 10.2174/138945012803530260

Prokaryotic substrate-binding proteins as targets for antimicrobial therapies

Counago, Rafael M., McDevitt, Christopher A., Ween, Miranda P. and Kobe, Bostjan (2012). Prokaryotic substrate-binding proteins as targets for antimicrobial therapies. Current Drug Targets, 13 (11), 1400-1410. doi: 10.2174/138945012803530170

Wzy-dependent bacterial capsules as potential drug targets

Ericsson, Daniel J., Standish, Alistair, Kobe, Bostjan and Morona, Renata (2012). Wzy-dependent bacterial capsules as potential drug targets. Current Drug Targets, 13 (11), 1421-1431. doi: 10.2174/138945012803530279

Computational modelling of linear motif-mediated protein interactions

Kobe, Bostjan and Boden, Mikael (2012). Computational modelling of linear motif-mediated protein interactions. Current Topics in Medicinal Chemistry, 12 (14), 1553-1561. doi: 10.2174/156802612802652439

Structural basis of nuclear import of flap endonuclease 1 (FEN1)

de Barros, Andrea C., Takeda, Agnes A. S., Chang, Chiung-Wen, Kobe, Bostjan and Fontes, Marcos R. M. (2012). Structural basis of nuclear import of flap endonuclease 1 (FEN1). Acta Crystallographica Section D: Biological Crystallography, 68 (7), 743-750. doi: 10.1107/S0907444912010281

Mapping the stabilome: a novel computational method for classifying metabolic protein stability

Patrick, Ralph, Cao, Kim-Anh L., Davis, Melissa, Kobe, Bostjan and Bodén, Mikael (2012). Mapping the stabilome: a novel computational method for classifying metabolic protein stability. BMC Systems Biology, 6 (1) 60, 60.1-60.15. doi: 10.1186/1752-0509-6-60

The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer

Chen, Kai-En, Richards, Ayanthi A., Arrifin, Juliana K., Ross, Ian L., Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer L. (2012). The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer. Acta Crystallographica Section D: Biological Crystallography, 68 (6), 637-648. doi: 10.1107/S0907444912006592

Structural basis of high-affinity nuclear localization signal interactions with importin-alpha

Marfori, Mary, Lonhienne, Thierry G., Forwood, Jade K. and Kobe, Bostjan (2012). Structural basis of high-affinity nuclear localization signal interactions with importin-alpha. Traffic, 13 (4), 532-548. doi: 10.1111/j.1600-0854.2012.01329.x

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing

Stark, Mitchell S., Woods, Susan L., Gartside, Michael G., Bonazzi, Vanessa F., Dutton-Regester, Ken, Aoude, Lauren G., Chow, Donald, Sereduk, Chris, Niemi, Natalie M., Tang, Nanyun, Ellis, Jonathan J., Reid, Jeffrey, Zismann, Victoria, Tyagi, Sonika, Muzny, Donna, Newsham, Irene, Wu, YuanQing, Palmer, Jane M., Pollak, Thomas, Youngkin, David, Brooks, Bradford R., Lanagan, Catherine, Schmidt, Christopher W., Kobe, Bostjan, MacKeigan, Jeffrey P., Yin, Hongwei, Brown, Kevin M., Gibbs, Richard, Trent, Jeffrey and Hayward, Nicholas K. (2012). Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nature Genetics, 44 (2), 165-169. doi: 10.1038/ng.1041

Conserved anchorless surface proteins as group A streptococcal vaccine candidates

Henningham, Anna, Chiarot, Emiliano, Gillen, Christine M., Cole, Jason N., Rohde, Manfred, Fulde, Marcus, Ramachandran, Vidiya, Cork, Amanda J., Hartas, Jon, Magor, Graham, Djordjevic, Steven P., Cordwell, Stuart J., Kobe, Bostjan, Sriprakash, Kabada S., Nizet, Victor, Chhatwal, G. S., Margarit, Immaculada Y. R., Batzloff, Michael R. and Walker, Mark J. (2012). Conserved anchorless surface proteins as group A streptococcal vaccine candidates. Journal of Molecular Medicine, 90 (10), 1197-1207. doi: 10.1007/s00109-012-0897-9

Residues in domain III of the dengue virus envelope glycoprotein involved in cell-surface glycosaminoglycan binding

Watterson, Daniel, Kobe, Bostjan and Young, Paul R. (2012). Residues in domain III of the dengue virus envelope glycoprotein involved in cell-surface glycosaminoglycan binding. Journal of General Virology, 93 (1), 72-82. doi: 10.1099/vir.0.037317-0

Crystallization and X-ray diffraction analysis of the C-terminal domain of the flax rust effector protein AvrM

Ve, Thomas, Williams, Simon J., Stamp, Anna, Valkov, Eugene, Dodds, Peter N., Anderson, Peter A. and Kobe, Bostjan (2011). Crystallization and X-ray diffraction analysis of the C-terminal domain of the flax rust effector protein AvrM. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 67 (12), 1603-1607. doi: 10.1107/S1744309111037675

A molecular mechanism for bacterial susceptibility to zinc

McDevitt, Christopher A., Ogunniyi, Abiodun D., Valkov, Eugene, Lawrence, Michael C., Kobe, Bostjan, McEwan, Alastair G. and Paton, James C. (2011). A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathogens, 7 (11) e1002357, e1002357.1-e1002357.9. doi: 10.1371/journal.ppat.1002357

Structural mix-n-match reveals molecular secrets of platelets

Kobe, Bostjan (2011). Structural mix-n-match reveals molecular secrets of platelets. Blood, 118 (19), 5065-5066. doi: 10.1182/blood-2011-09-379859

Ligand-induced conformational changes within a hexameric acyl-CoA thioesterase

Marfori, Mary, Kobe, Bostjan and Forwood, Jade K. (2011). Ligand-induced conformational changes within a hexameric acyl-CoA thioesterase. Journal of Biological Chemistry, 286 (41), 35643-35649. doi: 10.1074/jbc.M111.225953

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

Valkov, Eugene, Stamp, Anna, DiMaio, Frank, Baker, David, Verstak, Brett, Roversi, Pietro, Kellie, Stuart, Sweet, Matthew J., Mansell, Ashley, Gay, Nicholas J., Martin, Jennifer L. and Kobe, Bostjan (2011). Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Proceedings of the National Academy of Sciences of the United States of America, 108 (36), 14879-14884. doi: 10.1073/pnas.1104780108

Molecular basis for specificity of nuclear import and prediction of nuclear localization

Marfori, Mary, Mynott, Andrew, Ellis, Jonathan J., Mehdi, Ahmed M., Saunders, Neil F. W., Curmi, Paul M., Forwood, Jade K., Bodén, Mikael and Kobe, Bostjan (2011). Molecular basis for specificity of nuclear import and prediction of nuclear localization. Biochimica et Biophysica Acta (BBA): Molecular Cell Research, 1813 (9), 1562-1577. doi: 10.1016/j.bbamcr.2010.10.013

Structural basis of importin-alpha-mediated nuclear transport for Ku70 and Ku80

Takeda, Agnes A. S., de Barros, Andrea C., Chang, Chiung-Wen, Kobe, Boštjan and Fontes, Marcos R. M. (2011). Structural basis of importin-alpha-mediated nuclear transport for Ku70 and Ku80. Journal of Molecular Biology, 412 (2), 226-234. doi: 10.1016/j.jmb.2011.07.038

An autoactive mutant of the M flax rust resistance protein has a preference for binding ATP, whereas wild-type M protein binds ADP

Williams, Simon J., Sornaraj, Pradeep, deCourcy-Ireland, Emma, Menz, R. Ian, Kobe, Bostjan, Ellis, Jeffrey G., Dodds, Peter N. and Anderson, Peter A. (2011). An autoactive mutant of the M flax rust resistance protein has a preference for binding ATP, whereas wild-type M protein binds ADP. Molecular Plant-Microbe Interactions, 24 (8), 897-906. doi: 10.1094/MPMI-03-11-0052

Predicting protein kinase specificity : Predikin update and performance in the DREAM4 challenge

Ellis, Jonathan J. and Kobe, Bostjan (2011). Predicting protein kinase specificity : Predikin update and performance in the DREAM4 challenge. PLoS One, 6 (7) e21169, e21169-1-e21169-7. doi: 10.1371/journal.pone.0021169

Proteomic and electron microscopy survey of large assemblies in macrophage cytoplasm

Maco, B, Ross, IL, Landsberg, MJ, Mouradov, D, Saunders, NFW, Hankamer, B and Kobe, B (2011). Proteomic and electron microscopy survey of large assemblies in macrophage cytoplasm. Molecular and Cellular Proteomics, 10 (6) M111.008763, M111.008763. doi: 10.1074/mcp.M111.008763

A probabilistic model of nuclear import of proteins

Mehdi, Ahmed M., Sehgal, Muhammad Shoaib B., Kobe, Bostjan, Bailey, Timothy L. and Boden, Mikael (2011). A probabilistic model of nuclear import of proteins. Bioinformatics, 27 (9) btr121, 1239-1246. doi: 10.1093/bioinformatics/btr121

Crystal structure of importin-alpha bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4

Mynott, Andrew V., Harrop, Stephen J., Brown, Louise J., Breit, Samuel N., Kobe, Bostjan and Curmi, Paul M. G. (2011). Crystal structure of importin-alpha bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4. The FEBS Journal, 278 (10), 1662-1675. doi: 10.1111/j.1742-4658.2011.08086.x

Structural and functional analysis of a plant resistance protein TIR Domain reveals interfaces for self-association, signaling, and autoregulation

Bemoux, Maud, Ve, Thomas, Williams, Simon, Warren, Christopher, Hatters, Danny, Valkov, Eugene, Zhang, Xiaoxiao, Ellis, Jeffrey G., Kobe, Bostjan and Dodds, Peter N. (2011). Structural and functional analysis of a plant resistance protein TIR Domain reveals interfaces for self-association, signaling, and autoregulation. Cell Host and Microbe, 9 (3), 200-211. doi: 10.1016/j.chom.2011.02.009

Crystallization, X-ray diffraction analysis and preliminary structure determination of the TIR domain from the flax resistance protein L6

Ve, Thomas, Williams, Simon, Valkov, Eugene, Ellis, Jeffrey G., Dodds, Peter N. and Kobe, Bostjan (2011). Crystallization, X-ray diffraction analysis and preliminary structure determination of the TIR domain from the flax resistance protein L6. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 67 (2), 237-240. doi: 10.1107/S1744309110051006

Functional and structural properties of mammalian acyl-coenzyme A thioesterases

Kirkby, Brenda, Roman, Noelia, Kobe, Bostjan, Kellie, Stuart and Forwood, Jade K. (2010). Functional and structural properties of mammalian acyl-coenzyme A thioesterases. Progress in Lipid Research, 49 (4), 366-377. doi: 10.1016/j.plipres.2010.04.001

Science meets Parliament 2010

Pitson, S. and Kobe, B. (2010). Science meets Parliament 2010. Australian Biochemist, 41 (2), 40-41.

Quantitative structural analysis of Importin-β flexibility: Paradigm for solenoid protein structures

Forwood, JK, Lange, A, Zachariae, U, Marfori, M, Preast, C, Grubmuller, H, Stewart, M, Corbett, AH and Kobe, B (2010). Quantitative structural analysis of Importin-β flexibility: Paradigm for solenoid protein structures. Structure, 18 (9), 1171-1183. doi: 10.1016/j.str.2010.06.015

Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus

Morrow, CA, Stamp, A, Valkov, E, Kobe, B and Fraser, JA (2010). Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66 (9), 1104-1107. doi: 10.1107/S1744309110031659

Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening

Yang, Sny, Takeda, AAS, Fontes, MRM, Harris, JM, Jans, DA and Kobe, B (2010). Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening. Journal of Biological Chemistry, 285 (26), 19935-19946. doi: 10.1074/jbc.M109.079574

UpaH is a newly identified autotransporter protein that contributes to biofilm formation and bladder colonization by uropathogenic Escherichia coli CFT073

Allsopp, Luke P., Totsika, Makrina, Tree, Jai J., Ulett, Glen C., Mabbett, Amanda N., Wells, Timothy J., Kobe, Bostjan, Beatson, Scott A. and Schembri, Mark A. (2010). UpaH is a newly identified autotransporter protein that contributes to biofilm formation and bladder colonization by uropathogenic Escherichia coli CFT073. Infection and Immunity, 78 (4), 1659-1669. doi: 10.1128/IAI.01010-09

The AvrM Effector from flax rust has a structured C-terminal domain and interacts directly with the M resistance protein

Catanzariti, Ann-Maree, Dodds, Peter N., Ve, Thomas, Kobe, Bostjan, Ellis, Jeffrey G. and Staskawicz, Brian J. (2010). The AvrM Effector from flax rust has a structured C-terminal domain and interacts directly with the M resistance protein. Molecular Plant-Microbe Interactions, 23 (1), 49-57. doi: 10.1094/MPMI-23-1-0049

In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses

Kampmann, T., Yennamalli, R., Campbell, P., Stoermer, M. J., Fairlie, D. P., Kobe, B. and Young, P. R. (2009). In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses. Antiviral Research, 84 (3), 234-241. doi: 10.1016/j.antiviral.2009.09.007

The many faces of platelet glycoprotein Ib alpha - thrombin interaction

Kobe, B., Guncar, G., Buchholz, R., Huber, T. L. and Maco, B. (2009). The many faces of platelet glycoprotein Ib alpha - thrombin interaction. Current Protein and Peptide Science, 10 (6), 551-558. doi: 10.2174/138920309789630570

Interaction between plate make and protein in protein crystallisation screening

King, Gordon J., Chen, Kai-En, Robin, Gautier, Forwood, Jade K., Heras, Begoña, Thakur, Anil S., Kobe, Bostjan, Blomberg, Simon P. and Martin, Jennifer L. (2009). Interaction between plate make and protein in protein crystallisation screening. PLoS One, 4 (11) e7851, x-x. doi: 10.1371/journal.pone.0007851

Biochemical characterization of arabidopsis developmentally regulated G-proteins (DRGs)

O'Connell, A, Robin, G, Kobe, B and Botella, JR (2009). Biochemical characterization of arabidopsis developmentally regulated G-proteins (DRGs). PROTEIN EXPRESSION AND PURIFICATION, 67 (2), 88-95. doi: 10.1016/j.pep.2009.05.009

Importin-B is a GDP-to-GTP exchange factor of Ran: Implications for the mechanism of nuclear import

Lonhienne, Thierry G., Forwood, Jade K., Marfori, Mary, Robin, Gautier, Kobe, Bostjan and Carroll, Bernard J. (2009). Importin-B is a GDP-to-GTP exchange factor of Ran: Implications for the mechanism of nuclear import. Journal of Biological Chemistry, 284 (34), 22549-22558. doi: 10.1074/jbc.M109.019935

Defining the structural basis of human plasminogen binding by streptococcal surface enolase

Cork, A. J., Jergic, S., Hammerschmidt, S., Kobe, B., Pancholi, V., Benesch, J. L. P., Robinson, C. V., Dixon, N. E., Aquilina, J. A. and Walker, M. J. (2009). Defining the structural basis of human plasminogen binding by streptococcal surface enolase. Journal of Biological Chemistry, 284 (25), 17129-17137. doi: 10.1074/jbc.M109.004317

Crystallization of the flexible nuclear import receptor importin-beta in the unliganded state

Roman, Noelia, Kirkby, Brenda, Marfori, Mary, Kobe, Bostjan and Forwood, Jade K. (2009). Crystallization of the flexible nuclear import receptor importin-beta in the unliganded state. Acta Crystallographica Section F: Structural Biology and Crystallization Communications Online, 65 (6), 625-628. doi: 10.1107/S1744309109016820

Identification of novel target sites and an inhibitor of the dengue virus E protein

Yennamalli, Ragothaman, Subbarao, Naidu, Kampmann, Thorsten, McGeary, Ross P., Young, Paul R. and Kobe, Bostjan (2009). Identification of novel target sites and an inhibitor of the dengue virus E protein. Journal of Computer-Aided Molecular Design, 23 (6), 333-341. doi: 10.1007/s10822-009-9263-6

Crystallography and protein-protein interactions: Biological interfaces and crystal contacts

Kobe, Bostjan, Guncar, Gregor, Buchholz, Rebecca, Huber, Thomas, Maco, Bohumil, Cowieson, Nathan, Martin, Jennifer L., Marfori, Mary and Forwood, Jade K. (2008). Crystallography and protein-protein interactions: Biological interfaces and crystal contacts. Biochemical Society Transactions, 36 (6), 1438-1441. doi: 10.1042/BST0361438

Kap95p binding induces the switch loops of RanGDP to adopt the GTP-bound conformation: Implications for nuclear import complex assembly dynamics

Forwood, Jade K., Lonhienne, Thierry G., Marfori, Mary, Robin, Gautier, Meng, Weining, Guncar, Gregor, Liu, Sai M., Stewart, Murray, Carroll, Bernard J. and Kobe, Bostjan (2008). Kap95p binding induces the switch loops of RanGDP to adopt the GTP-bound conformation: Implications for nuclear import complex assembly dynamics. Journal of Molecular Biology, 383 (4), 772-782. doi: 10.1016/j.jmb.2008.07.090

United we stand: combining structural methods

Cowieson, Nathan P., Kobe, Bostjan and Martin, Jennifer L. (2008). United we stand: combining structural methods. Current Opinion in Structural Biology, 18 (5), 617-622. doi: 10.1016/j.sbi.2008.07.004

Soybean Nodule Autoregulation Receptor Kinase Phosphorylates Two Kinase-associated Protein Phosphatases in Vitro

Miyahara, A., Hirani, T., Oakes, M., Kereszt, A., Kobe, B., Djordjevic, M.A. and Gresshoff, P. M. (2008). Soybean Nodule Autoregulation Receptor Kinase Phosphorylates Two Kinase-associated Protein Phosphatases in Vitro. Journal of Biological Chemistry, 283 (37), 25381-25391. doi: 10.1074/jbc.M800400200

Increasing protein crystallization screening success with heterogeneous nucleating agents

Thakur, Anil S, Newman, Janet, Martin, Jennifer L and Kobe, Bostjan (2008). Increasing protein crystallization screening success with heterogeneous nucleating agents. Methods in molecular biology (Clifton, N.J.), 426, 403-409. doi: 10.1007/978-1-60327-058-8_26

Federated repositories of X-ray diffraction images

Androulakis, S., Schmidberger, J., Bate, M. A., DeGori, R., Beitz, A., Keong, C., Cameron, B., McGowan, S., Porter, C. J., Harrison, A., Hunter, J., Martin, J. L., Kobe, B., Dobson, R. C. J., Parker, M. W., Whisstock, J. C., Gray, J., Treloar, A., Groenewegen, D., Dickson, N. and Buckle, A. M. (2008). Federated repositories of X-ray diffraction images. Acta Crystallographica Section D: Biological Crystallography, 64 (7), 810-814. doi: 10.1107/S0907444908015540

Identification of Disulfide-containing chemical cross-links in proteins using MALDI-TOF/TOF-MAss spectrometry

King, G. J., Jones, A., Kobe, B., Huber, T., Mouradov, D., Hume, D. A. and Ross, I. L. (2008). Identification of Disulfide-containing chemical cross-links in proteins using MALDI-TOF/TOF-MAss spectrometry. Analytical Chemistry, 80 (13), 5036-5043. doi: 10.1021/ac702277q

Cortactin adopts a globular conformation and bundles actin into sheets

Cowieson, Nathan P., King, Gordon, Cookson, David, Ross, Ian, Huber, Thomas, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2008). Cortactin adopts a globular conformation and bundles actin into sheets. The Journal of Biological Chemistry, 283 (23), 16187-16193. doi: 10.1074/jbc.M708917200

Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites

Saunders, N., Brinkworth, R.I., Huber, T. L., Kemp, B.E. and Kobe, B. (2008). Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites. BMC Bioinformatics, 9 (245) 245, 1-11. doi: 10.1186/1471-2105-9-245

Discovering sequence motifs with arbitrary insertions and deletions

Frith, Martin C., Saunders, Neil F. W., Kobe, Bostjan and Bailey, Timothy L. (2008). Discovering sequence motifs with arbitrary insertions and deletions. PLoS Computational Biology, 4 (5) e1000071, e1000071.1-e1000071.12. doi: 10.1371/journal.pcbi.1000071

Fibroblast growth factor receptor 2 phosphorylation on Serine 779 couples to 14-3-3 and regulates cell survival and proliferation

Lonic, A., Barry, E.F., Quach, C., Kobe, B., Saunders, N. and Guthridge, M.A. (2008). Fibroblast growth factor receptor 2 phosphorylation on Serine 779 couples to 14-3-3 and regulates cell survival and proliferation. Molecular & Cellular Biology, 28 (10), 3372-3385. doi: 10.1128/MCB.01837-07

Evaluating protein: Protein complex formation using synchrotron radiation circular dichroism spectroscopy

Cowieson, Nathan P., Miles, Andrew J., Robin, Gautier, Forwood, Jade K., Kobe, Bostjan, Martin, Jennifer L. and Wallace, B. A. (2008). Evaluating protein: Protein complex formation using synchrotron radiation circular dichroism spectroscopy. Proteins: Structure Function Bioinformatics, 70 (4), 1142-1146. doi: 10.1002/prot.21631

Histidine protonation and the activation of viral fusion proteins

Mueller, D., Kampmann, T., Yennamalli, R., Young, P.R., Kobe, B. and Mark, A. E. (2008). Histidine protonation and the activation of viral fusion proteins. Biochemical Society Transactions, 36 (1), 43-45. doi: 10.1042/BST0360043

Structural proteomics: high-throughput methods. Preface

Kobe, Bostjan, Guss, Mitchell and Huber, Thomas (2008). Structural proteomics: high-throughput methods. Preface. Methods in molecular biology (Clifton, N.J.), 426, v-vi. doi: 10.1007/978-1-60327-058-8

The Predikin webserver: improved prediction of protein kinase peptide specificity using structural information

Saunders, Neil F. W. and Kobe, Bostjan (2008). The Predikin webserver: improved prediction of protein kinase peptide specificity using structural information. Nucleic Acids Research, 36 (suppl 2), W286-W290. doi: 10.1093/nar/gkn279

Improved Success of Sparse Matrix Protein Crystallization Screening with Heterogeneous Nucleating Agents

Thakur, A., Robin, G., Guncar, G., Saunders, N., Newman, J., Martin, J. L. and Kobe, B. (2007). Improved Success of Sparse Matrix Protein Crystallization Screening with Heterogeneous Nucleating Agents. PLoS ONE, 2 (10) e1091, e1091-1-e1091-6. doi: 10.1371/journal.pone.0001091

Crystal structures of flax rust avirulence proteins AvrL567-A and -D reveal details of the structural basis for flax disease resistance specificity

Wang, C., Guncar, G., Forwood, J., Teh, T., Catanzariti, A., Lawrence, G., Loughlin, F., Mackay, J., Schirra, H., Anderson, P., Ellis, J., Dodds, P. and Kobe, B. (2007). Crystal structures of flax rust avirulence proteins AvrL567-A and -D reveal details of the structural basis for flax disease resistance specificity. Plant Cell, 19 (9), 2898-2912. doi: 10.1105/tpc.107.053611

Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation

Forwood, J., Thakur, A., Guncar, G., Marfori, M., Mouradov, D., Meng, W., Robinson, J., Huber, T., Kellie, S., Martin, J. L., Hume, D. and Kobe, B. (2007). Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation. Proceedings of The National Academy of Sciences of The United States of America, 104 (25), 10382-10387. doi: 10.1073/pnas.0700974104

The use of Co2+ for crystallization and structure determination, using a conventional monochromatic X-ray source, of flax rust avirulence protein

Guncar, G., Wang, C., Forwood, J., Teh, T., Catanzariti, A., Ellis, J., Dodds, P. and Kobe, B (2007). The use of Co2+ for crystallization and structure determination, using a conventional monochromatic X-ray source, of flax rust avirulence protein. Acta Crystallographica Section F-structural Biology And Crystallization Communications, 63 (3), 209-213. doi: 10.1107/S1744309107004599

Purification of the M flax-rust resistance protein expressed in Pichia pastoris

Schmidt, S., Williams, S., Wang, C., Sornaraj, P., James, B., Kobe, B., Dodds, P., Ellis, J. and Anderson, P. (2007). Purification of the M flax-rust resistance protein expressed in Pichia pastoris. Plant Journal, 50 (6), 1107-1117. doi: 10.1111/j.1365-313X.2007.03104.x

Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases

Bogoyevitch, Marie A. and Kobe, Bostjan (2006). Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiology and Molecular Biology Reviews, 70 (4), 1061-1095. doi: 10.1128/MMBR.00025-06

Direct protein interaction underlies gene-for-gene specificity and coevolution of the flax resistance genes and flax rust avirulence genes

Dodds, P. N., Lawrence, G. J., Cantanzariti, A. M., Teh, T., Wang, C. I. A., Ayliffe, M. A., Kobe, B. and Ellis, J. G. (2006). Direct protein interaction underlies gene-for-gene specificity and coevolution of the flax resistance genes and flax rust avirulence genes. Proceedings of the National Academy of Science of the United States of America, 103 (23), 8888-8893. doi: 10.1073/pnas.0602577103

An automatable screen for the rapid identification of proteins amenable to refolding

Cowieson, Nathan P., Wensley, Beth, Listwan, Pawel, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2006). An automatable screen for the rapid identification of proteins amenable to refolding. Proteomics, 6 (6), 1750-1757. doi: 10.1002/pmic.200500056

Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase

Serek, R., Forwood, J. K., Hume, D. A., Martin, J. L. and Kobe, B. (2006). Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase. Acta Crystallographica Section F-structural Biology And Crystallization Communications, 62, 133-135. doi: 10.1107/S17443091060000030

Focusing in on structural genomics: The University of Queensland structural biology pipeline

Puri, M., Robin, G., Cowieson, N., Forwood, J. K., Listwan, P., Hu, S. H., Guncar, G., Huber, T., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2006). Focusing in on structural genomics: The University of Queensland structural biology pipeline. Biomolecular Engineering, 23 (6), 281-289. doi: 10.1016/j.bioeng.2006.09.002

Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins

Kurz, M., Cowieson, N. P., Robin, G., Hume, D. A., Martin, J. L., Kobe, B. and Listwan, P. (2006). Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins. Protein Expression And Purification, 50 (1), 68-73. doi: 10.1016/j.pep.2006.05.006

Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking

Mouradov, D., Craven, A., Forwood, J. K., Flanagan, J. U., Garcia-Castellanos, R., Gomis-Ruth, F. X., Hume, D. A., Martin, J. L., Kobe, B. and Huber, T. (2006). Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking. Protein Engineering Design & Selection, 19 (1), 9-16. doi: 10.1093/protein/gzi070

Protein kinases associated with the yeast phosphoproteome

Brinkworth, Ross I., Munn, Alan L. and Kobe, Bostjan (2006). Protein kinases associated with the yeast phosphoproteome. Bmc Bioinformatics, 7 (47) 47, 47. doi: 10.1186/1471-2105-7-47

The role of histidine residues in low-pH-mediated viral membrane fusion

Kampmann, Thorsten, Meuller, Daniela S., Mark, Alan E., Young, Paul R. and Kobe, Bostjan (2006). The role of histidine residues in low-pH-mediated viral membrane fusion. Structure, 14 (10), 1481-1487. doi: 10.1016/j.str.2006.07.011

Substrate specifity of protein kinases and computational prediction of substrates

Kobe, Bostjan, Kampmann, Thorsten, Forwood, Jade K., Listwan, Pawel and Brinkworth, Ross I. (2005). Substrate specifity of protein kinases and computational prediction of substrates. Biochimica et Biophysica Acta, 1754 (1-2), 200-209. doi: 10.1016/j.bbapap.2005.07.036

An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1

Aagaard, A., Listwan, P., Cowieson, N. P., Huber, T. L., Ravasi, T., Wells, C. A., Flanagan, J. U., Kellie, S., Hume, D. A., Kobe, B. and Martin, J. L. (2005). An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1. Structure, 13 (2), 309-317. doi: 10.1016/j.str.2004.12.013

Crystallization and preliminary X-ray diffraction analysis of importin-alpha acomplexed with NLS peptidomimetics

Fontes, M. R. M., Teh, T., Riell, R. D., Park, S. B., Standaert, R. E. and Kobe, B. (2005). Crystallization and preliminary X-ray diffraction analysis of importin-alpha acomplexed with NLS peptidomimetics. Biochimica Et Biophysica Acta-proteins And Proteomics, 1750 (1), 9-13. doi: 10.1016/j.bbapap.2005.03.014

Modification of recombinatorial cloning for small affinity tag fusion protein construct generation

Listwan, P, Cowieson, N, Kurz, M, Hume, DA, Martin, JL and Kobe, B (2005). Modification of recombinatorial cloning for small affinity tag fusion protein construct generation. Analytical Biochemistry, 346 (2), 327-329. doi: 10.1016/j.ab.2005.06.016

Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system

Cowieson, N. P., Listwan, P., Kurz, M., Aagaard, A., Ravasi, T., Wells, C. A., Huber, T. L., Hume, D. A., Kobe, B. and Martin, J. L. (2005). Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system. Journal of Structural and Functional Genomics, 6 (1), 13-20. doi: 10.1007/s10969-005-0462-7

Verprolin cytokinesis function mediated by the Hof one trap domain

Ren, Gang, Wang, Juan, Brinkworth, Ross, Winsor, Barbara, Kobe, Bostjan and Munn, Alan L. (2005). Verprolin cytokinesis function mediated by the Hof one trap domain. Traffic, 6 (7), 575-593. doi: 10.1111/j.1600-0854.2005.00300.x

Comment on 'Protein isoelectric point as a predictor for increased crystallization screening efficiency'

Huber, T. L. and Kobe, B. (2004). Comment on 'Protein isoelectric point as a predictor for increased crystallization screening efficiency'. Bioinformatics, 20 (14), 2169-2170. doi: 10.1093/bioinformatics/bth452

Expression and biochemical analysis of the entire HIV-2 gp41 ectodomain: determinants of stability map to N- and C-terminal sequences outside the 6-helix bundle core

Lay, C. S., Wilson, K. A., Kobe, B., Kemp, B. E., Drummer, H. E. and Poumbourios, P. (2004). Expression and biochemical analysis of the entire HIV-2 gp41 ectodomain: determinants of stability map to N- and C-terminal sequences outside the 6-helix bundle core. Febs Letters, 567 (2-3), 183-188. doi: 10.1016/j.febslet.2004.04.054

Methods for high-throughput protein expression, purification and structure determination adapted for structural genomics

Listwan, P., Martin, J. L., Kobe, B. and Cowieson, N. P. (2004). Methods for high-throughput protein expression, purification and structure determination adapted for structural genomics. Australian Biochemist, 35 (2), 43-46.

Structural and Functional Genomics

Kobe, Bostjan (2004). Structural and Functional Genomics. Australian Biochemist, 35 (2)

Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-a

Fontes, R. M., Teh, T., Toth, G., John, A.I., Pavo, I. D. A., Jans, D. A. and Kobe, B. (2003). Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-a. Biochemical Journal, 375 (2), 339-349. doi: 10.1042/BJ20030510

Comparison of three commercial sparse-matrix crystallization screens

Wooh, J. W., Kidd, R. D., Martin, J. L. and Kobe, B. (2003). Comparison of three commercial sparse-matrix crystallization screens. Acta Crystallographica Section D: Biological Crystallography, 59 (4), 769-772. doi: 10.1107/S0907444903002919

Crystal structures of fusion proteins with large-affinity tags

Smyth, Douglas R., Mrozkiewicz, Marek K., McGrath, William J., Listwan, Pawel and Kobe, Bostjan (2003). Crystal structures of fusion proteins with large-affinity tags. Protein Science, 12 (7), 1313-1322. doi: 10.1110/ps.0243403

Great Expectations: Structural Biology Amidst World Politics

Kobe, B. (2003). Great Expectations: Structural Biology Amidst World Politics. Australian Biochemist, 34 (1), 24-27.

Structural basis and prediction of substrate specificity in protein serine/threonine kinases

Brinkworth, R. I., Breinl, R. A. and Kobe, B. (2003). Structural basis and prediction of substrate specificity in protein serine/threonine kinases. Proceedings of The National Academy of Sciences of The United States of America, 100 (1), 74-79. doi: 10.1073/pnas.0134224100

Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-α

Fontes, R. Marcos, Teh, Trazel, Jans, David A., Brinkworth, Ross I. and Kobe, Bostjan (2003). Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-α. Journal of Biological Chemistry, 278 (30), 27981-27987. doi: 10.1074/jbc.M303275200

Intramolecular autoregulatory sequences in proteins

Kobe, Bostjan (2002). Intramolecular autoregulatory sequences in proteins. Croatica Chemica Acta, 75 (3), 805-816.

A computational analysis of substrate binding strength by phosphorylase kinase and protein kinase A

Brinkworth, R. I., Horne, J. and Kobe, B. (2002). A computational analysis of substrate binding strength by phosphorylase kinase and protein kinase A. Journal of Molecular Recognition, 15 (2), 104-111. doi: 10.1002/jmr.563

Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information

Kajava, A. V. and Kobe, B. (2002). Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information. Protein Science, 11 (5), 1082-1090. doi: 10.1110/ps.4010102

Structural characterization of the N-terminal autoregulatory sequence of phenylalanine hydroxylase

Horne, J., Jennings, I. G., Teh, T., Gooley, P. R. and Kobe, B. (2002). Structural characterization of the N-terminal autoregulatory sequence of phenylalanine hydroxylase. Protein Science, 11 (8), 2041-2047. doi: 10.1110/ps.4560102

The leucine-rich repeat as a protein recognition motif

Kobe, Bostjan and Kajava, Andrey V. (2001). The leucine-rich repeat as a protein recognition motif. Current Opinion In Structural Biology, 11 (6), 725-732. doi: 10.1016/S0959-440X(01)00266-4

Biophysical characterization of interactions involving importin-alpha during nuclear import

Catimel, B., Teh, T., Fontes, M. R. M., Jennings, I. G., Jans, D. A., Howlett, G. J., Nice, E. C. and Kobe, B. (2001). Biophysical characterization of interactions involving importin-alpha during nuclear import. Journal of Biological Chemistry, 276 (36), 34189-34198. doi: 10.1074/jbc.M103531200

Crystallization and crystal structure determination of ribomuclease A-ribonuclease inhibitor protein complex

Kobe, B. (2001). Crystallization and crystal structure determination of ribomuclease A-ribonuclease inhibitor protein complex. Methods in Molecular Biology, 160, 201-211. doi: 10.1385/1-59259-233-3:201

Crystallization and preliminary X-ray diffraction studies of FHA domains of Dun1 and Rad53 protein kinases

Blanchard, H., Fontes, R. M, Hammet, A., Pike, B. L., Teh, T., Gleichmann, T., Gooley, P. R., Kobe, B. and Heierhorst, J. (2001). Crystallization and preliminary X-ray diffraction studies of FHA domains of Dun1 and Rad53 protein kinases. Acta Crystallographica Section D: Biological Crystallography, 57 (3), 459-461. doi: 10.1107/S0907444901002116

Essential role of the N-terminal autoregulatory sequence in the regulation of phenylalanine hydroxylase

Jennings, I. G., Teh, T. and Kobe, B. (2001). Essential role of the N-terminal autoregulatory sequence in the regulation of phenylalanine hydroxylase. Febs Letters, 488 (3), 196-200. doi: 10.1016/S0014-5793(00)02426-1

Structural genomics: Protein structures for the masses?

Walsh, C. R., Hume, D. A., Kobe, B. and Martin, J. L. (2001). Structural genomics: Protein structures for the masses?. Australian Biochemist, 32 (2), 13-16.

Functional implications of the human T-lymphotropic virus type 1 transmembrane glycoprotein helical hairpin structure

Maerz, Anne L., Center, Rob J., Kemp, Bruce E., Kobe, Bostjan and Poumbourios, Pantelis (2000). Functional implications of the human T-lymphotropic virus type 1 transmembrane glycoprotein helical hairpin structure. Journal of Virology, 74 (14), 6614-6621. doi: 10.1128/JVI.74.14.6614-6621.2000

FHA domain boundaries of the Dun1p and Rad53p cell cycle checkpoint kinases

Hammet, A, Pike, BL, Mitchelhill, KI, Teh, T, Kobe, B, House, CM, Kemp, BE and Heierhorst, J (2000). FHA domain boundaries of the Dun1p and Rad53p cell cycle checkpoint kinases. Febs Letters, 471 (2-3), 141-146. doi: 10.1016/S0014-5793(00)01392-2

Functional analysis, using in vitro mutagenesis, of amino acids located in the phenylalanine hydroxylase active site

Jennings, IG, Cotton, RGH and Kobe, B (2000). Functional analysis, using in vitro mutagenesis, of amino acids located in the phenylalanine hydroxylase active site. Archives of Biochemistry And Biophysics, 384 (2), 238-244. doi: 10.1006/abbi.2000.2111

Identification and predicted structure of a leucine-rich repeat motif shared by Leishmania major proteophosphoglycan and Parasite Surface Antigen 2

Montgomery, J, Ilg, T, Thompson, JK, Kobe, B and Handman, E (2000). Identification and predicted structure of a leucine-rich repeat motif shared by Leishmania major proteophosphoglycan and Parasite Surface Antigen 2. Molecular And Biochemical Parasitology, 107 (2), 289-295. doi: 10.1016/S0166-6851(00)00186-9

Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha

Fontes, MRM, Teh, T and Kobe, B (2000). Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha. Journal of Molecular Biology, 297 (5), 1183-1194. doi: 10.1006/jmbi.2000.3642

Structural interpretation of mutations in phenylalanine hydroxylase protein aids in identifying genotype-phenotype correlations in phenylketonuria

Jennings, IG, Cotton, RGH and Kobe, B (2000). Structural interpretation of mutations in phenylalanine hydroxylase protein aids in identifying genotype-phenotype correlations in phenylketonuria. European Journal of Human Genetics, 8 (9), 683-696. doi: 10.1038/sj.ejhg.5200518

When protein folding is simplified to protein coiling: the continuum of solenoid protein structures

Kobe, B and Kajava, AV (2000). When protein folding is simplified to protein coiling: the continuum of solenoid protein structures. Trends in Biochemical Sciences, 25 (10), 509-515. doi: 10.1016/S0968-0004(00)01667-4

Active site-directed protein regulation

Kobe, B and Kemp, BE (1999). Active site-directed protein regulation. Nature, 402 (6760), 373-376. doi: 10.1038/46478

Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha

Kobe, B (1999). Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha. Nature Structural Biology, 6 (4), 388-397. doi: 10.1038/7625

Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins

Kobe, B, Center, RJ, Kemp, BE and Poumbourios, P (1999). Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins. Proceedings of The National Academy of Sciences of The United States of America, 96 (8), 4319-4324. doi: 10.1073/pnas.96.8.4319

Crystallization of importin alpha, the nuclear-import receptor

Teh, T, Tiganis, T and Kobe, B (1999). Crystallization of importin alpha, the nuclear-import receptor. Acta Crystallographica Section D: Biological Crystallography, 55 (2), 561-563. doi: 10.1107/S0907444998012943

Evolutionary conservation of the membrane fusion machine

Poumbourios, P, Center, RJ, Wilson, KA, Kemp, BE and Kobe, B (1999). Evolutionary conservation of the membrane fusion machine. Iubmb Life, 48 (2), 151-156. doi: 10.1080/713803503

Structural basis of autoregulation of phenylalanine hydroxylase

Kobe, B, Jennings, IG, House, CM, Michell, BJ, Goodwill, KE, Santarsiero, BD, Stevens, RC, Cotton, RGH and Kemp, BE (1999). Structural basis of autoregulation of phenylalanine hydroxylase. Nature Structural Biology, 6 (5), 442-448. doi: 10.1038/8247

Turn up the HEAT

Kobe, B, Gleichmann, T, Horne, J, Jennings, IG, Scotney, PD and Teh, T (1999). Turn up the HEAT. Structure, 7 (5), R91-R97. doi: 10.1016/S0969-2126(99)80060-4

Crystallization and preliminary X-ray analysis of ferric enterobactin receptor FepA, an integral membrane protein from Escherichia coli

Smith, Barbara S., Kobe, Bostjan, Kurumbail, Ravi, Buchanan, Susan K., Venkatramani, Lalitha, van der Helm, Dick and Deisenhofer, Johann (1998). Crystallization and preliminary X-ray analysis of ferric enterobactin receptor FepA, an integral membrane protein from Escherichia coli. Acta crystallographica: Section D, Biological crystallography, 54 (4), 697-699. doi: 10.1107/S0907444997020222

Crystallization of a trimeric human T cell leukemia virus type 1 gp21 ectodomain fragment as a chimera with maltose-binding protein

Center, RJ, Kobe, B, Wilson, KA, Teh, T, Howlett, GJ, Kemp, BE and Poumbourios, P (1998). Crystallization of a trimeric human T cell leukemia virus type 1 gp21 ectodomain fragment as a chimera with maltose-binding protein. Protein Science, 7 (7), 1612-1619. doi: 10.1002/pro.5560070715

Open up review system

Kobe, B (1998). Open up review system. Nature, 396 (6711), 509-509. doi: 10.1038/24969

Protein phosphorylation: In-charge and networking!

Kemp, B. E., Kobe, B. and Heierhorst, J. (1998). Protein phosphorylation: In-charge and networking!. Australian Biochemist, 29, 11-13.

Erratum: Leucines on a roll (Nature Structural Biology (1996) 3:12 (977- 980))

Kobe, B. (1997). Erratum: Leucines on a roll (Nature Structural Biology (1996) 3:12 (977- 980)). Nature Structural Biology, 4 (4). doi: 10.1038/nsb0497-327

Intrasteric regulation of protein kinases

Kobe, B, Heierhorst, J and Kemp, BE (1997). Intrasteric regulation of protein kinases. Signal Transduction In Health And Disease, 31, 29-40.

Regulation and crystallization of phosphorylated and dephosphorylated forms of truncated dimeric phenylalanine hydroxylase

Kobe, B, Jennings, IG, House, CM, Feil, SC, Michell, BJ, Tiganis, T, Parker, MW, Cotton, RGH and Kemp, BE (1997). Regulation and crystallization of phosphorylated and dephosphorylated forms of truncated dimeric phenylalanine hydroxylase. Protein Science, 6 (6), 1352-1357. doi: 10.1002/pro.5560060626

The myosin-I-binding protein Acan125 binds the SH3 domain and belongs to the superfamily of leucine-rich repeat proteins

Xu, P, Mitchelhill, KI, Kobe, B, Kemp, BE and Zot, HG (1997). The myosin-I-binding protein Acan125 binds the SH3 domain and belongs to the superfamily of leucine-rich repeat proteins. Proceedings of The National Academy of Sciences of The United States of America, 94 (8), 3685-3690. doi: 10.1073/pnas.94.8.3685

Ca2+ /S100 regulation of giant protein kinases

Heierhorst, Jörg, Kobe, Bostjan, Feil, Susanne C., Parker, Michael W., Benian, Guy M., Weiss, Klaudiusz R. and Kemp, Bruce E. (1996). Ca2+ /S100 regulation of giant protein kinases. Nature, 380 (6575), 636-639. doi: 10.1038/380636a0

Giant protein kinases: Domain interactions and structural basis of autoregulation

Kobe, B, Heierhorst, J, Feil, SC, Parker, MW, Benian, GM, Weiss, KR and Kemp, BE (1996). Giant protein kinases: Domain interactions and structural basis of autoregulation. Embo Journal, 15 (24), 6810-6821. doi: 10.1002/j.1460-2075.1996.tb01072.x

Intrasteric regulation of calmodulin-dependent protein kinases

Kemp, B. E., Barden, J. A., Kobe, B., House, C. and Parker, M. W. (1996). Intrasteric regulation of calmodulin-dependent protein kinases. Advances in Pharmacology, 36 (C), 221-249. doi: 10.1016/S1054-3589(08)60584-0

Leucines on a roll

Kobe, Bostjan (1996). Leucines on a roll. Nature Structural Biology, 3 (12), 977-980. doi: 10.1038/nsb1296-977

Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease A

Kobe, B and Deisenhofer, J (1996). Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease A. Journal of Molecular Biology, 264 (5), 1028-1043. doi: 10.1006/jmbi.1996.0694

Proteins with leucine-rich repeats

Kobe, Bostjan and Deisenhofer, Johann (1995). Proteins with leucine-rich repeats. Current Opinion in Structural Biology, 5 (3), 409-416. doi: 10.1016/0959-440X(95)80105-7

A structural basis of the interactions between leucine-rich repeats and protein ligands

Kobe, Bostjan and Deisenhofer, Johann (1995). A structural basis of the interactions between leucine-rich repeats and protein ligands. Nature, 374 (6518), 183-186. doi: 10.1038/374183a0

Complex between bovine ribonuclease A and porcine ribonuclease inhibitor crystallizes in a similar unit cell as free ribonuclease inhibitor

Kobe, Bestjan, Ma, Zhiquan and Deisenhofer, Johann (1994). Complex between bovine ribonuclease A and porcine ribonuclease inhibitor crystallizes in a similar unit cell as free ribonuclease inhibitor. Journal of Molecular Biology, 241 (2), 288-291. doi: 10.1006/jmbi.1994.1502

The leucine-rich repeat: a versatile binding motif

Kobe, Bostjan and Deisenhofer, Johann (1994). The leucine-rich repeat: a versatile binding motif. Trends In Biochemical Sciences, 19 (10), 415-421. doi: 10.1016/0968-0004(94)90090-6

Conformational behavior of Escherichia coli OmpA signal peptides in membrane mimetic environments

Rizo, Josep, Blanco, Francisco J., Kobe, Bostjan, Bruch, Martha D. and Gierasch, Lila M. (1993). Conformational behavior of Escherichia coli OmpA signal peptides in membrane mimetic environments. Biochemistry, 32 (18), 4881-4894. doi: 10.1021/bi00069a025

Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats

Kobe, Bostjan and Deisenhofer, Johann (1993). Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Nature, 366 (6457), 751-756. doi: 10.1038/366751a0

Crystallization and preliminary X-ray analysis of porcine ribonuclease inhibitor, a protein with leucine-rich repeats

Kobe, Bostjan and Deisenhofer, Johann (1993). Crystallization and preliminary X-ray analysis of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Journal of Molecular Biology, 231 (1), 137-140. doi: 10.1006/jmbi.1993.1263

Use of distance geometry approach for the in vitro antiviral activity evaluation of N-bridgehead C-nucleosides

Kobe, B., Kobe, J., Smee, D. F., Jerman-Blazic-Dzonova, B. and Solmajer, T. (1992). Use of distance geometry approach for the in vitro antiviral activity evaluation of N-bridgehead C-nucleosides. European Journal of Medicinal Chemistry, 27 (3), 259-266. doi: 10.1016/0223-5234(92)90010-X

Structural evolution of an enzyme specificity. The structure of rat carboxypeptidase A2 at 1.9-A resolution

Faming, Z., Kobe, B., Stewart, C. B., Rutter, W. J. and Goldsmith, E. J. (1991). Structural evolution of an enzyme specificity. The structure of rat carboxypeptidase A2 at 1.9-A resolution. The Journal of Biological Chemistry, 266 (36), 24606-24612.

Structural basis of TIR-domain assembly formation in TRAM- and TRIF- dependent TLR signalling

Pan, M., Hedger, A., Nanson, J., Pospich, S., Ve, T. V. E. A., Raunser, S., Landsberg, M. and Kobe, B. (2022). Structural basis of TIR-domain assembly formation in TRAM- and TRIF- dependent TLR signalling. 2022 American Crystallographic Association Meeting, Portland, OR USA, 29 July-3 August 2022. Hoboken, NJ USA: Wiley-Blackwell Publishing. doi: 10.1107/s2053273322093196

Animal TIR domains inform the molecular and structural basis of signaling by plant NLR TIR domains

Kobe, B., Burdett, H., Zhang, X., Chen, J., Rank, M. X., Horsefield, S., Manik, M. K., Shi, Y., Qi, T., Dry, I. B., Williams, S. J., Staskawicz, B. J., Ve, T. and Dodds, P. N. (2019). Animal TIR domains inform the molecular and structural basis of signaling by plant NLR TIR domains. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.1

Interaction and structural study between plant TIR-containing NLRs and EDS1 immune regulatory complex

Rank, M. X., Kobe, B., Burdett, H., Horsefield, S., Manik, M. K., Zhang, X. and Shi, Y. (2019). Interaction and structural study between plant TIR-containing NLRs and EDS1 immune regulatory complex. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.1

Self-association and an intact NADase active site are required for plant TIR domain immune signaling

Chen, J., Zhang, X., Burdett, H., Rank, M. X., Ve, T., Rathjen, J., Kobe, B. and Dodds, P. N. (2019). Self-association and an intact NADase active site are required for plant TIR domain immune signaling. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.1

Structural and Biochemical Analysis of Plant TIR NAD plus Cleavage Activity

Burdett, H., Rank, M. X., Chen, J., Zhang, X., Shi, Y., Ve, T., Dodds, P. N. and Kobe, B. (2019). Structural and Biochemical Analysis of Plant TIR NAD plus Cleavage Activity. 18th Congress of International Society for Molecular Plant Microbe Interactions (IS-MPMI), Glasgow, Scotland, 14-18 July, 2019. St. Paul, MN, United States: American Phytopathological Society. doi: 10.1094/MPMI-32-10-S1.213

Crystallographic and calorimetric studies with nuclear transport of DNA repair proteins

de Mattos Fontes, Marcos Roberto, de Barros, Andrea, Bernardes, Natalia, Takeda, Agnes, Dreyer, Thiago, Bertolini, Maria Celia and Kobe, Bostjan (2018). Crystallographic and calorimetric studies with nuclear transport of DNA repair proteins. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1107/S2053273318092434

Prion - like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ?

O'Carroll, Allis, Ve, Thomas, Moustaqil, Mehdi, Giles, Nichole, Bhumkar, Akshay, Hunter, Dominic, Kobe, Bostjan, Sierecki, Emma and Gambin, Yann (2017). Prion - like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ?. Annual Meeting of the American-Society-for-Pharmacology-and-Experimental-Therapeutics (ASPET) at Experimental Biology Meeting, Chicago, IL USA, Apr 22-26, 2017. Bethesda, MD, USA: Federation of American Societies for Experimental Biology.

Structural characterisation of SARM in axon degeneration and cell death

Horsefield, Shane Michael, Ve, Thomas, Zhang, Xiaoxiao, Casey, Lachlan and Kobe, Bostjan (2017). Structural characterisation of SARM in axon degeneration and cell death. IUCr Congress, Hyderabad, India, 21-28 August 2017. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1107/S205327331708740X

Structural characterization of pseudo-dihyroorotase domain in yeast URA2

Jeon, Yujung, Ross, Ian, Landsberg, Michael, Hankamer, Ben and Kobe, Bostjan (2017). Structural characterization of pseudo-dihyroorotase domain in yeast URA2. XXIV IUCr Congress, Hyderabad, India, 21-28 August 2017. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1107/s2053273317090325

Structural characterization of dihydroorotase domain in yeast CAD multienzyme

Jeon, Yujung, Ross, Ian, Landsberg, Michael, Schultz, Ben, Hankamer, Ben and Kobe, Bostjan (2016). Structural characterization of dihydroorotase domain in yeast CAD multienzyme. 30th European Crystallographic Meeting, Basel, Switzerland, 28 August - 1 September 2016. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273316096807

Comparing METS and OAI-ORE for encapsulating scientific data products: A protein crystallography case study

Brooking, Charles, Shouldice, Stephen R., Robin, Gautier, Kobe, Bostjan, Martin, Jennifer L. and Hunter, Jane (2009). Comparing METS and OAI-ORE for encapsulating scientific data products: A protein crystallography case study. IEEE International Conference on e-Science and Grid Computing [e-Science], Oxford, U.K., 9-11 December 2009. Los Alamitos, CA, U.S.A.: Institute for Electrical and Electronic Engineers (IEEE). doi: 10.1109/e-Science.2009.29

Dengue viral envelope protein and histidine protonation

Yennamalli, RM, Kobe, B, Mark, AE, Young, PR and Subbarao, N (2009). Dengue viral envelope protein and histidine protonation. XVIII National Conference of Indian Virological Society, Post Graduate Institute of Medical Education and Research, Chandigarh, India., 11–13 December 2008. HISAR: Indian Virological Society.

Functional genomic analysis of systemic cell division regulation in legumes

Gresshoff, P. M., Indrasumunar, A., Miyahara, A., Nontachaiyapoom, S., Biswas, B., Lin, Y-H., Lin, M-H, Reid, D., Callahan, D., Capon, R., Zhang, H., Jiang, Q., Hirani, T., Kobe, B., Men, A., Scott, P., Kereszt, A., Miyagi, M., Li, D., Chan, P-K., Roessner, U., Djordjevic, M. A., Kinkema, M. and Ferguson, B. (2009). Functional genomic analysis of systemic cell division regulation in legumes. International Symposium on Induced Mutations in Plants, Vienna, Austria, 2–15 August 2008. Vienna, Austria: Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture.

Application of bioinformatic/biochemical hybrid approach to determine the structure of protein complexes and multi-domain proteins

Mouradov, D. A., Forwood, J. K., Ross, I. L., King, G. F., Sinz, A., Kobe, B. and Huber, T. L. (2006). Application of bioinformatic/biochemical hybrid approach to determine the structure of protein complexes and multi-domain proteins. ComBio 2006, Brisbane, Australia, 24-28 September, 2006. Kent Town, Australia: Australian Society for Biochemistry and Molecular Biology.

Exit on the other side please; crystal structure of the ACOT7 C-terminal domain

Guncar, G, Forwood, J K, Mouradov, D. A., Serek, R. A., Mafori, M., Huber, T L, Martin, J L and Kobe, B (2006). Exit on the other side please; crystal structure of the ACOT7 C-terminal domain. ComBio 2006, Brisbane, 24-28 Sept, 2006.

In silico screening and structure based drug design for the envelope protein of flaviviruses

Yennamalli Madhava R, R., Kampmann, T., Subbarao, N., Kobe, B and Young, P R (2006). In silico screening and structure based drug design for the envelope protein of flaviviruses. 7th Asia Pacific Congress of Virology, New Delhi, 13-15 Nov, 2006.

In silico screening and structure based drug design for the envelope protein of flaviviruses

Yennamalli Madhava R, R., Kampmann, T., Subbarao, N., Kobe, B. and Young, P. R. (2006). In silico screening and structure based drug design for the envelope protein of flaviviruses. 5th International Conference on Bioinformatics, New Delhi, India, 18-20 Dec, 2006.

Multiple targets for antiviral inhibitors

Young, P. R., Chappell, K. J., Stoermer, M. J., Fairlie, D., Kampmann, T. and Kobe, B. (2006). Multiple targets for antiviral inhibitors. 7th Asia Pacific Congress of Virology, New Delhi, 13-15 Nov, 2006.

Prediction of protein kinase substrates using sequence-structure information

Saunders, F W, Brinkworth, R. I., Huber, T L and Kobe, B (2006). Prediction of protein kinase substrates using sequence-structure information. ComBio 2006, Brisbane, 24-28 Sept, 2006.

Rapid identification of DTSSP crosslinked peptides using LCMALDI Tof-Tof mass spectrometry

King, G. F., Jones, A., Cowieson, N. P., Huber, T. L., Kobe, B. and Ross, I. L. (2006). Rapid identification of DTSSP crosslinked peptides using LCMALDI Tof-Tof mass spectrometry. ComBio 2006, Brisbane, Australia, 24-28 Sept, 2006. Kent Town, Australia: Australian Society for Biochemistry and Molecular Biology.

The mechanism of vira membrane fusion and identification of novel antiviral lead compounds

Kampmann, T., Muller,, Robinson, J., Mark, A, Young, P R and Kobe, B (2006). The mechanism of vira membrane fusion and identification of novel antiviral lead compounds. 31st Lorne Conference on Protein Structure & Function, Lorne, Victoria, Australia, 5-9 Feb, 2006.

Two hot dogs are better than one: Structural and biochemical insights into mammalian long-chain acyl-COA hydrolase

Forwood, J K, Mouradov, D. A., Guncar, G, Mafori, M., Serek, R. A., Martin, J L, Huber, T L and Kobe, B (2006). Two hot dogs are better than one: Structural and biochemical insights into mammalian long-chain acyl-COA hydrolase. ComBio 2006, Brisbane, 24-28 Sept, 2006.

University of Queensland structural genomics pipeline

Robin, G, Cowieson, N P, Forwood, J K, Guncar, G, Listwan, P., Huber, T L, Kobe, B and Martin, J L (2006). University of Queensland structural genomics pipeline. ComBio 2006, Brisbane, 24-28 Sept, 2006.

A structural model for low pH mediated viral fusion: The role of histidine protonation

Kampmann, T., Muller, D. A., Robinson, J., Mark, A., Young, P. R. and Kobe, B. (2005). A structural model for low pH mediated viral fusion: The role of histidine protonation. 3rd Australian Virology Group Meeting, Phillip Island, 9-12 Dec, 2005.

Dengue virus mediated fusion as a target for antiviral drug design

Young, P. R., Robinson, J., Kampmann, T. and Kobe, B. (2005). Dengue virus mediated fusion as a target for antiviral drug design. 2nd Asian Dengue Meeting, Singapore, 28-30 Sept, 2005.

Development of antiviral drugs targeting the flavivirus fusion mechanism

Kampmann, T., Yennamalli Madhava R, R., Stoermer, M. J., Kobe, B. and Young, P. R. (2005). Development of antiviral drugs targeting the flavivirus fusion mechanism. 30th Lorne Conference on Protein Structure & Function, Lorne, 6-10 Feb, 2005.

Development of antiviral drugs targeting the flaviviruses fusion mechanism

Kampmann, T., Yennamalli, R., Stoermer, M., Kobe, B. and Young, P. (2005). Development of antiviral drugs targeting the flaviviruses fusion mechanism. 30th FEBS Congress - 9th IUBMB Conference, Budapest, Hungary, 2-7tJuly 2005. Oxford, England: Blackwell Publishing. doi: 10.1111/j.1742-4658.2005.4739_15.x

Discovery of antiviral inhibitors targeting the fusion mechanism of the flavivirus family members Dengue, Kunjin and Yellow fever

Kampmann, T., Yennamalli Madhava R, R., Stoermer, M. J., Kobe, B. and Young, P. R. (2005). Discovery of antiviral inhibitors targeting the fusion mechanism of the flavivirus family members Dengue, Kunjin and Yellow fever. 30th FEBS Congress - 9th Int Union of Biochem & Molecular Biof, Budapest, 2-7 July, 2005.

In silico screening and structure based drug design for the envelope protein of flaviviruses

Yennamalli Madhava R. R., Kampmann, T., Rao, N. S., Kobe, B. and Young, P. R. (2005). In silico screening and structure based drug design for the envelope protein of flaviviruses. 3rd Australian Virology Group Meeting, Phillip Island, Vic, 9-12 December, 2005.

Prediction of substrate specificities of protein kinases

Kobe, B. and Brinkworth, R. I. (2005). Prediction of substrate specificities of protein kinases. 4th International Conference Inhibitors of Protein Kinases, Warsaw, 25-29 June, 2005. Cell Mol Biol Lett.

Structural studies with the importin alpha complexed with nuclear localization sequence peptidomimetics

Fontes, M. R. M., Takeda, A. A. S., Teh, T., Standaert, R. F. and Kobe, B. (2005). Structural studies with the importin alpha complexed with nuclear localization sequence peptidomimetics. Int Union Biochem Molecular Biol 50th Anniversary Symposium, Budapest, Hungary, 2nd - 7th July, 2005. Oxford, U.K.: Blackwell. doi: 10.1111/j.1742-4658.2005.4739_14.x

Protein regulation, protein-protein interactions and structural genomics

Kobe, Bostjan (2003). Protein regulation, protein-protein interactions and structural genomics. Ljubljana, Slovenia: Slovensko Kemijsko Drus.

Clues to interaction between CSF-1 and CSF-1R from specificity and structure

Hamwood, T., Kobe, B., Smythe, M. L. and Hume, D. A. (2002). Clues to interaction between CSF-1 and CSF-1R from specificity and structure. Australian Society of Immunologists Meeting, Brisbane, 1-5 December, 2002.

Prediction of substrate specificity in protein kinases

Kobe, B., Breinl, R. A. and Brinkworth, R. I. (2002). Prediction of substrate specificity in protein kinases. ComBio 2002, Sydney, 29 September - 3 October, 2002.

Protein regulation, protein-protein interactions and structural genomics

Kobe, B. (2002). Protein regulation, protein-protein interactions and structural genomics. First Central European Conference Chemistry Towards Biology, Portoroz, Slovenia, 8-12 September, 2002.

Structural genomics of novel macrophage proteins associated with inflammatory disease and cancer

Listwan, P., Walsh, C. R., Ravasi, T., Wells, C. A., Cowieson, N. P., Hume, D. A., Martin, J. L. and Kobe, B. (2002). Structural genomics of novel macrophage proteins associated with inflammatory disease and cancer. International Conference on Structural Genomics, Berlin, 10-13 October, 2002.

Structural genomics of novel proteins induced in macrophages in response to lipopolysaccharide

Walsh, C. R., Listwan, P., Serek, R. A., Cowieson, N. P., Barry, G., Ross, I. L., Ravasi, T., Wells, C. A., Jerala, R., Martin, J. L., Kobe, B. and Hume, D. A. (2002). Structural genomics of novel proteins induced in macrophages in response to lipopolysaccharide. ComBio2002, Darling Harbour Convention Centre, Sydney, Australia, 29 September -3 October, 2002.

Structure and functions analysis of leucine rich repeat containing proteins involved in the macrophage response to bacterial lipopolysaccharide

Walsh, C. R., Listwan, P., Serek, R. A., Cowieson, N. P., Gee, C. L., Barry, G., Ross, I. L., Ravasi, T., Wells, C. A., Jerala, R., Martin, J. L., Hume, D. A. and Kobe, B. (2002). Structure and functions analysis of leucine rich repeat containing proteins involved in the macrophage response to bacterial lipopolysaccharide. Australian Society for Immunology Meeting, Brisbane, 1-5 December, 2002.

Structure and regulation of phenylalanine hydroxylase, and implications for related enzymes

Kobe, B., Jennings, I.G. and Cotton, R.G.H. (2002). Structure and regulation of phenylalanine hydroxylase, and implications for related enzymes. 12th Int Symposium on Pteridines and Folates, Bethesda, USA, 17-22 June, 2001. USA: Kluwer Academic Publishers.

The scope of intrasteric (active site-directed) protein regulation

Kobe, B. (2002). The scope of intrasteric (active site-directed) protein regulation. First Wellcome Trust Conference for International Snr Fellows, London, 30 April - 1 May, 2002.

Structural basis of phenylketonuria

Cotton, R. H., Jennings, I. G. and Kobe, B. (1999). Structural basis of phenylketonuria. xx, October, 1999. Chicago, IL: University of Chicago Press.

Conformations of wild type and mutant OmpA signal sequences in membrane mimetic environments

Rizo, J., Blanco, F., Kobe, B., Bruch, M. D., Hoyt, D. W. and Gierasch, L. M. (1992). Conformations of wild type and mutant OmpA signal sequences in membrane mimetic environments. 12th American Peptide Symposium, Cambridge, Massachusetts, U.S.A., 16-21 June, 1991. Leiden, The Netherlands: ESCOM.