Dr Jodi Saunus

Postdoctoral Research Scientist

UQ Centre for Clinical Research
Faculty of Medicine
j.saunus@uq.edu.au
+61 7 334 66030

Overview

Dr Jodi Saunus is a Senior Fellow and Brain Metastasis Program Leader at the UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital Campus in Herston. She has an honours degree in biochemistry and biomedical science, a PhD (UQ, 2006) in breast cancer molecular genetics, and post-doctoral experience in immunology, molecular cell biology and molecular pathology. She has published in prominent medical research journals including Cancer Research, Nature, Nature Communications and The Journal of Pathology, and with a fantastic group of mentors and collaborators, secured more than $2.5M in competitive research funding in the last 5 years alone.

Her research portfolio is centred on finding new ways to improve the clinical management of aggressive breast cancer, with a focus on metastatic brain disease. This multidisciplinary program involves identifying mechanisms that facilitate the outgrowth of cancer cells in the brain using experimental models of brain metastasis, as well as molecular profiling of human clinical samples to identify features that correlate with treatment response and survival. She also coordinates the 'BoNSAI' study, a clinical PET/MR imaging trial run through the Herston Imaging Research Facility (HIRF), which aims to measure physiologic factors (intratumoural pressure, vascular permeability and fluid flow dynamics) that influence how therapeutics are taken up into brain tumours.

In terms of strategic and administrative roles, she oversees operational aspects of the Brisbane Breast Bank, is a member of the kConFab biospecimens and UQCCR Industry & Commercialisation committees, mentors/supervises two junior postdoctoral scientists and two PhD students. She is a strong proponent for consumer engagement in research, and regularly addresses community groups about breast cancer research at the UQCCR and beyond.

Qualifications

  • PhD, The University of Queensland
  • Bachelor of Science (Hons), The University of Queensland

Publications

  • Joo, Jihoon E., Dowty, James G., Milne, Roger L., Wong, Ee Ming, Dugué, Pierre-Antoine, English, Dallas, Hopper, John L., Goldgar, David E., Giles, Graham G., Southey, Melissa C., kConFab, Sexton, Adrienne, Christian, Alice, Trainer, Alison, Spigelman, Allan, Fellows, Andrew, Shelling, Andrew, De Fazio, Anna, Blackburn, Anneke, Crook, Ashley, Meiser, Bettina, Patterson, Briony, Clarke, Christine, Saunders, Christobel, Hunt, Clare, Scott, Clare, Amor, David, Marsh, Deborah, Edkins, Edward, Salisbury, Elizabeth, Haan, Eric, Neidermayr, Eveline, Macrae, Finlay, Farshid, Gelareh, Lindeman, Geoff, Chenevix-Trench, Georgia, Mann, Graham, Gill, Grantley, Thorne, Heather, Campbell, Ian, Hickie, Ian, Winship, Ingrid, Goldblatt, Jack, Flanagan, James, Kollias, James, Visvader, Jane, Stone, Jennifer, Taylor, Jessica, Burke, Jo, Saunus, Jodi, Forbes, John, Beesley, Jonathan, Kirk, Judy, French, Juliet, Tucker, Kathy, Wu, Kathy, Phillips, Kelly, Lipton, Lara, Andrews, Leslie, Lobb, Elizabeth, Walker, Logan, Kentwell, Maira, Spurdle, Amanda, Cummings, Margaret, Gleeson, Margaret, Harris, Marion, Jenkins, Mark, Young, Mary Anne, Delatycki, Martin, Wallis, Mathew, Burgess, Matthew, Price, Melanie, Brown, Melissa, Bogwitz, Michael, Field, Michael, Friedlander, Michael, Gattas, Michael, Saleh, Mona, Hayward, Nick, Pachter, Nick, Cohen, Paul, Duijf, Pascal, James, Paul, Butow, Phyllis, Simpson, Peter, Fong, Peter, Williams, Rachael, Kefford, Richard, Scott, Rodney, Balleine, Rosemary, Dawson, Sarah-Jane, Lok, Sheau, O'Connell, Shona, Greening, Sian, Nightingale, Sophie, Edwards, Stacey, Fox, Stephen, McLachlan, Sue-Anne, Lakhani, Sunil, Thomas, Susan and Antill, Yoland (2018) Heritable DNA methylation marks associated with susceptibility to breast cancer. Nature Communications, 9 1: . doi:10.1038/s41467-018-03058-6

  • Kalimutho, Murugan, Sinha, Debottam, Jeffery, Jessie, Nones, Katia, Srihari, Sriganesh, Fernando, Winnie C., Duijf, Pascal H. G., Vennin, Claire, Raninga, Prahlad, Nanayakkara, Devathri, Mittal, Deepak, Saunus, Jodi M., Lakhani, Sunil R., López, J Alejandro, Spring, Kevin J., Timpson, Paul, Gabrielli, Brian, Waddell, Nicola and Khanna, Kum Kum (2018) CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. EMBO Molecular Medicine, 10 9: e8566. doi:10.15252/emmm.201708566

  • McCart Reed, Amy E., Kutasovic, Jamie R., Nones, Katia, Saunus, Jodi M., Da Silva, Leonard, Newell, Felicity, Kazakoff, Stephen, Melville, Lewis, Jayanthan, Janani, Vargas, Ana Cristina, Reid, Lynne E., Beesley, Jonathan, Chen, Xiao Qing, Patch, Anne Marie, David Clouston, D., Porter, Alan, Evans, Elizabeth, Pearson, John V., Chenevix-Trench, Georgia, Cummings, Margaret C., Waddell, Nic, Lakhani, Sunil R. and Simpson, Peter T. (2018) Mixed ductal-lobular carcinomas: evidence for progression from ductal to lobular morphology. The Journal of Pathology, 244 4: 460-468. doi:10.1002/path.5040

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Grants

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Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book Chapter

  • Saunus, Jodi M., McCart-Reed, Amy, Momeny, Majid, Cummings, Margaret and Lakhani, Sunil R. (2013). Breast cancer heterogeneity in primary and metastatic disease. In Aamir Ahmad (Ed.), Breast Cancer Metastasis and Drug Resistance: Challenges and Progress (pp. 65-95) New York, NY, USA: Springer. doi:10.1007/978-1-4614-5647-6

Journal Article

  • Joo, Jihoon E., Dowty, James G., Milne, Roger L., Wong, Ee Ming, Dugué, Pierre-Antoine, English, Dallas, Hopper, John L., Goldgar, David E., Giles, Graham G., Southey, Melissa C., kConFab, Sexton, Adrienne, Christian, Alice, Trainer, Alison, Spigelman, Allan, Fellows, Andrew, Shelling, Andrew, De Fazio, Anna, Blackburn, Anneke, Crook, Ashley, Meiser, Bettina, Patterson, Briony, Clarke, Christine, Saunders, Christobel, Hunt, Clare, Scott, Clare, Amor, David, Marsh, Deborah, Edkins, Edward, Salisbury, Elizabeth, Haan, Eric, Neidermayr, Eveline, Macrae, Finlay, Farshid, Gelareh, Lindeman, Geoff, Chenevix-Trench, Georgia, Mann, Graham, Gill, Grantley, Thorne, Heather, Campbell, Ian, Hickie, Ian, Winship, Ingrid, Goldblatt, Jack, Flanagan, James, Kollias, James, Visvader, Jane, Stone, Jennifer, Taylor, Jessica, Burke, Jo, Saunus, Jodi, Forbes, John, Beesley, Jonathan, Kirk, Judy, French, Juliet, Tucker, Kathy, Wu, Kathy, Phillips, Kelly, Lipton, Lara, Andrews, Leslie, Lobb, Elizabeth, Walker, Logan, Kentwell, Maira, Spurdle, Amanda, Cummings, Margaret, Gleeson, Margaret, Harris, Marion, Jenkins, Mark, Young, Mary Anne, Delatycki, Martin, Wallis, Mathew, Burgess, Matthew, Price, Melanie, Brown, Melissa, Bogwitz, Michael, Field, Michael, Friedlander, Michael, Gattas, Michael, Saleh, Mona, Hayward, Nick, Pachter, Nick, Cohen, Paul, Duijf, Pascal, James, Paul, Butow, Phyllis, Simpson, Peter, Fong, Peter, Williams, Rachael, Kefford, Richard, Scott, Rodney, Balleine, Rosemary, Dawson, Sarah-Jane, Lok, Sheau, O'Connell, Shona, Greening, Sian, Nightingale, Sophie, Edwards, Stacey, Fox, Stephen, McLachlan, Sue-Anne, Lakhani, Sunil, Thomas, Susan and Antill, Yoland (2018) Heritable DNA methylation marks associated with susceptibility to breast cancer. Nature Communications, 9 1: . doi:10.1038/s41467-018-03058-6

  • Kalimutho, Murugan, Sinha, Debottam, Jeffery, Jessie, Nones, Katia, Srihari, Sriganesh, Fernando, Winnie C., Duijf, Pascal H. G., Vennin, Claire, Raninga, Prahlad, Nanayakkara, Devathri, Mittal, Deepak, Saunus, Jodi M., Lakhani, Sunil R., López, J Alejandro, Spring, Kevin J., Timpson, Paul, Gabrielli, Brian, Waddell, Nicola and Khanna, Kum Kum (2018) CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. EMBO Molecular Medicine, 10 9: e8566. doi:10.15252/emmm.201708566

  • McCart Reed, Amy E., Kutasovic, Jamie R., Nones, Katia, Saunus, Jodi M., Da Silva, Leonard, Newell, Felicity, Kazakoff, Stephen, Melville, Lewis, Jayanthan, Janani, Vargas, Ana Cristina, Reid, Lynne E., Beesley, Jonathan, Chen, Xiao Qing, Patch, Anne Marie, David Clouston, D., Porter, Alan, Evans, Elizabeth, Pearson, John V., Chenevix-Trench, Georgia, Cummings, Margaret C., Waddell, Nic, Lakhani, Sunil R. and Simpson, Peter T. (2018) Mixed ductal-lobular carcinomas: evidence for progression from ductal to lobular morphology. The Journal of Pathology, 244 4: 460-468. doi:10.1002/path.5040

  • Johnson, Julie, Bessette, Darrell C., Saunus, Jodi M., Smart, Chanel E., Song, Sarah, Johnston, Rebecca L., Cocciardi, Sibylle, Rozali, Esdy N., Johnstone, Cameron N., Vargas, Ana Christina, Kazakoff, Stephen H., BioBank, Victorian Cancer, Khanna, Kum Kum, Lakhani, Sunil R., Chenevix-Trench, Georgia, Simpson, Peter T., Nones, Katia, Waddell, Nicola and Al-Ejeh, Fares (2018) Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient. Breast Cancer Research and Treatment, 170 1: 179-188. doi:10.1007/s10549-018-4719-9

  • Raghavendra, Ashwini, Kalita-de Croft, Priyakshi, Vargas, Ana Cristina, Smart, Chanel E., Simpson, Peter T., Saunus, Jodi M. and Lakhani, Sunil R. (2018) Expression of MAGE-A and NY-ESO-1 cancer-testis antigens is enriched in triple-negative invasive breast cancers. Histopathology, 73 1: 68-80. doi:10.1111/his.13498

  • McCart Reed, Amy E., Saunus, Jodi M., Ferguson, Kaltin, Niland, Colleen, Simpson, Peter T. and Lakhani, Sunil R. (2018) The Brisbane Breast Bank. Open Journal of Bioresources, 5 5: . doi:10.5334/ojb.33

  • Saunus, Jodi M., Smart, Chanel E., Kutasovic, Jamie R., Johnston, Rebecca L., Kalita-de Croft, Priyakshi, Miranda, Mariska, Rozali, Esdy N., Vargas, Ana Cristina, Reid, Lynne E., Lorsy, Eva, Cocciardi, Sibylle, Seidens, Tatjana, McCart Reed, Amy E., Dalley, Andrew J., Wockner, Leesa F., Johnson, Julie, Sarkar, Debina, Askarian-Amiri, Marjan E., Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia, Al-Ejeh, Fares and Lakhani, Sunil R. (2017) Multidimensional phenotyping of breast cancer cell lines to guide preclinical research. Breast Cancer Research and Treatment, 167 1: 1-13. doi:10.1007/s10549-017-4496-x

  • Hernandez-Perez, S., Cabrera, E., Salido, E., Lim, M., Reid, L., Lakhani, S. R., Khanna, K. K., Saunus, J. M. and Freire, R. (2017) DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer. Oncogene, 36 33: 4802-4809. doi:10.1038/onc.2017.21

  • Saunus, Jodi M., McCart Reed, Amy E., Lim, Zhun Leong and Lakhani, Sunil R. (2017) Breast cancer brain metastases: clonal evolution in clinical context. International Journal of Molecular Sciences, 18 1: . doi:10.3390/ijms18010152

  • Kalita-De Croft, Priyakshi, Al-Ejeh, Fares, McCart Reed, Amy E., Saunus, Jodi M. and Lakhani, Sunil R. (2016) 'Omics approaches in breast cancer research and clinical practice. Advances in Anatomic Pathology, 23 6: 356-367. doi:10.1097/PAP.0000000000000128

  • Burgess, Joshua T., Bolderson, Emma, Saunus, Jodi M., Zhang, Shu-Dong, Reid, Lynne E., McNicol, Anne Marie, Lakhani, Sunil R., Cuff, Katharine, Richard, Kerry, Richard, Derek J. and O'Byrne, Kenneth J. (2016) SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer. Oncotarget, 7 45: 72807-72818. doi:10.18632/oncotarget.12020

  • Milevskiy, Michael J. G., Al-Ejeh, Fares, Saunus, Jodi M., Northwood, Korinne S., Bailey, Peter J., Betts, Joshua A., McCart Reed, Amy E., Nephew, Kenneth P., Stone, Andrew, Gee, Julia M. W., Dowhan, Dennis H., Dray, Eloise, Shewan, Annette M., French, Juliet D., Edwards, Stacey L., Clark, Susan J., Lakhani, Sunil R. and Brown, Melissa A. (2016) Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer. Human Molecular Genetics, 25 15: 3269-3283. doi:10.1093/hmg/ddw177

  • Peters, Amelia A., Milevskiy, Michael J. G., Lee, WeiC., Curry, Merril C., Smart, Chanel E., Saunus, Jodi M., Reid, Lynne, da Silva, Leonard, Marcial, Daneth L., Dray, Eloise, Brown, Melissa A., Lakhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016) The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin. Scientific Reports, 6 . doi:10.1038/srep25505

  • Field, Sarah, Uyttenhove, Catherine, Stroobant, Vincent, Cheou, Paméla, Coutelier, Jean-Paul, Simpson, Peter T., Cummings, Margaret C., Saunus, Jodi M., Reid, Lynne E., Kutasovic, Jamie R., McNicol, Anne Marie, Kim, Ba Reun, Kim, Jae Ho, Lakhani, Sunil R., Neville, A. Munro, Van Snick, Jacques and Jat, Parmjit S. (2016) Novel highly specific anti-periostin antibodies uncover the functional importance of the fascilin 1-1 domain and highlight preferential expression of periostin in aggressive breast cancer. International Journal of Cancer, 138 8: 1959-1970. doi:10.1002/ijc.29946

  • Pelttari, Liisa M., Khan, Sofia, Vuorela, Mikko, Kiiski, Johanna I., Vilske, Sara, Nevanlinna, Viivi, Ranta, Salla, Schleutker, Johanna, Winqvist, Robert, Kallioniemi, Anne, Dörk, Thilo, Bogdanova, Natalia V., Figueroa, Jonine, Pharoah, Paul D. P., Schmidt, Marjanka K., Dunning, Alison M., García-Closas, Montserrat, Bolla, Manjeet K., Dennis, Joe, Michailidou, Kyriaki, Wang, Qin, Hopper, John L., Southey, Melissa C., Rosenberg, Efraim H., Fasching, Peter A., Beckmann, Matthias W., Peto, Julian, Dos-Santos-silva, Isabel, Sawyer, Elinor J., Tomlinson, Ian, Burwinkel, Barbara, Surowy, Harald, Guénel, Pascal, Truong, Thérèse, Bojesen, Stig E., Nordestgaard, Børge G., Benitez, Javier, González-Neira, Anna, Neuhausen, Susan L., Anton-Culver, Hoda, Brenner, Hermann, Arndt, Volker, Meindl, Alfons, Schmutzler, Rita K., Brauch, Hiltrud, Brüning, Thomas, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Hartikainen, Jaana M., Chenevix-Trench, Georgia, Van Dyck, Laurien, Janssen, Hilde, Chang-Claude, Jenny, Rudolph, Anja, Radice, Paolo, Peterlongo, Paolo, Hallberg, Emily, Olson, Janet E., Giles, Graham G., Milne, Roger L., Haiman, Christopher A., Schumacher, Fredrick, Simard, Jacques, Dumont, Martine, Kristensen, Vessela, Borresen-Dale, Anne-Lise, Zheng, Wei, Beeghly-Fadiel, Alicia, Grip, Mervi, Andrulis, Irene L., Glendon, Gord, Devilee, Peter, Seynaeve, Caroline, Hooning, Maartje J., Collée, Margriet, Cox, Angela, Cross, Simon S., Shah, Mitul, Luben, Robert N., Hamann, Ute, Torres, Diana, Jakubowska, Anna, Lubinski, Jan, Couch, Fergus J., Yannoukakos, Drakoulis, Orr, Nick, Swerdlow, Anthony, Darabi, Hatef, Li, Jingmei, Czene, Kamila, Hall, Per, Easton, Douglas F., Mattson, Johanna, Blomqvist, Carl, Aittomäki, Kristiina, Nevanlinna, Heli, Aghmesheh, Morteza, Amor, David, Andrews, Lesley, Antill, Yoland, Armitage, Shane, Arnold, Leanne, Balleine, Rosemary, Bankier, Agnes, Bastick, Patti, Beesley, Jonathan, Beilby, John, Bennett, Barbara, Bennett, Ian, Berry, Geoffrey, Blackburn, Anneke, Bogwitz, Michael, Brennan, Meagan, Brown, Melissa, Buckley, Michael, Burgess, Matthew, Burke, Jo, Butow, Phyllis, Byron, Keith, Callen, David, Campbell, Ian, Chauhan, Deepa, Christian, Alice, Clarke, Christine, Colley, Alison, Cotton, Dick, Crook, Ashley, Cui, James, Culling, Bronwyn, Cummings, Margaret, Dawson, Sarah-Jane, DeFazio, Anna, Delatycki, Martin, Dickson, Rebecca, Dixon, Joanne, Dobrovic, Alexander, Dudding, Tracy, Edkins, Ted, Edwards, Stacey, Eisenbruch, Maurice, Farshid, Gelareh, Fawcett, Susan, Fellows, Andrew, Fenton, Georgina, Field, Michael, Firgaira, Frank, Flanagan, James, Fleming, Jean, Fong, Peter, Forbes, John, Fox, Stephen, French, Juliet, Friedlander, Michael, Gaff, Clara, Gardner, Mac, Gattas, Mike, George, Peter, Giles, Graham, Gill, Grantley, Goldblatt, Jack, Greening, Sian, Grist, Scott, Haan, Eric, Hardie, Kate, Harris, Marion, Hart, Stewart, Hayward, Nick, Healey, Sue, Heiniger, Louise, Hopper, John, Humphrey, Evelyn, Hunt, Clare, James, Paul, Jenkins, Mark, Jones, Alison, Kefford, Rick, Kidd, Alexa, Kiely, Belinda, Kirk, Judy, Koehler, Jessica, Kollias, James, Kovalenko, Serguei, Lakhani, Sunil, Leaming, Amanda, Leary, Jennifer, Lim, Jacqueline, Lindeman, Geoff, Lipton, Lara, Lobb, Liz, Mann, Graham, Marsh, Deborah, McLachlan, Sue Anne, Meiser, Bettina, Meldrum, Cliff, Milne, Roger, Mitchell, Gillian, Newman, Beth, Nightingale, Sophie, O'Connell, Shona, O'Loughlin, Imeldao, Osborne, Richard, Pachter, Nick, Patterson, Briony, Peters, Lester, Phillips, Kelly, Price, Melanie, Purser, Lynne, Reeve, Tony, Reeve, Jeanne, Richards, Robert, Rickard, Edwina, Robinson, Bridget, Rudzki, Barney, Saleh, Mona, Salisbury, Elizabeth, Sambrook, Joe, Saunders, Christobel, Saunus, Jodi, Sayer, Robyn, Scott, Elizabeth, Scott, Rodney, Scott, Clare, Seshadri, Ram, Sexton, Adrienne, Sharma, Raghwa, Shelling, Andrew, Simpson, Peter, Southey, Melissa, Spurdle, Amanda, Suthers, Graeme, Sykes, Pamela, Taylor, Donna, Taylor, Jessica, Thierry, Benjamin, Thompson, Ella, Thorne, Heather, Townshend, Sharron, Trainer, Alison, Tran, Lan, Tucker, Kathy, Tyler, Janet, Visvader, Jane, Walker, Logan, Walpole, Ian, Ward, Robin, Waring, Paul, Warner, Bev, Warren, Graham, Williams, Rachael, Wilson, Judy, Winship, Ingrid, Wu, Kathy, Young, Mary Ann, Stuart-Harris, R., Kirsten, F., Rutovitz, J., Clingan, P., Glasgow, A., Proietto, A., Braye, S., Otton, G., Shannon, J., Bonaventura, T., Stewart, J., Begbie, S., Bell, D., Baron-Hay, S., Ferrier, A., Gard, G., Nevell, D., Pavlakis, N., Valmadre, S., Young, B., Camaris, C., Crouch, R., Edwards, L., Hacker, N., Marsden, D., Robertson, G., Beale, P., Beith, J., Carter, J., Dalrymple, C., Houghton, R., Russell, P., Anderson, L., Links, M., Grygiel, J., Hill, J., Brand, A., Byth, K., Jaworski, R., Harnett, P., Wain, G., Purdie, D., Whiteman, D., Ward, B., Papadimos, D., Crandon, A., Horwood, K., Obermair, A., Perrin, L., Wyld, D., Nicklin, J., Davy, S. A.M., Oehler, M. K., Hall, C., Dodd, T., Healy, T., Pittman, K., Henderson, D., Miller, J., Pierdes, J., Achan, A., Blomfield, P., Challis, D., McIntosh, R., Parker, A., Brown, B., Rome, R., Allen, D., Grant, P., Hyde, S., Laurie, R., Robbie, M., Healy, D., Jobling, T., Manolitsas, T., McNealage, J., Rogers, P., Susil, B., Sumithran, E., Simpson, I., Haviv, I., Phillips, K., Rischin, D., Fox, S., Johnson, D., Lade, S., Loughrey, M., O'Callaghan, N., Murray, B., Mileshkin, L., Allan, P., Billson, V., Pyman, J., Neesham, D., Quinn, M., Hamilton, A., McNally, O., Underhill, C., Bell, R., Ng, L. F., Blum, R., Ganju, V., Hammond, I., Leung, Y., McCartney, A., Stewart, C. and Zeps, N. (2016) RAD51B in familial breast cancer. PLoS One, 11 5: . doi:10.1371/journal.pone.0153788

  • Zhang, Lin, Zhang, Siyuan, Yao, Jun, Lowery, Frank J., Zhang, Qingling, Huang, Wen-Chien, Li, Ping, Li, Min, Wang, Xiao, Zhang, Chenyu, Wang, Hai, Ellis, Kenneth, Cheerathodi, Mujeeburahiman, McCarty, Joseph H., Palmieri, Diane, Saunus, Jodi, Lakhani, Sunil, Huang, Suyun, Sahin, Aysegul A., Aldape, Kenneth D., Steeg, Patricia S. and Yu, Dihua (2015) Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature, 527 7576: 100-104. doi:10.1038/nature15376

  • Saunus, Jodi M., Quinn, MIchael C. J., Patch, Ann-Marie, Pearson, John V., Bailey, Peter J., Nones, Katia, McCart Reed, Amy E., Miller, David, Peter J. Wilson, Al-Ejeh, Fares, Mariasegaram, Mythily, Lau, Queenie, Withers, Teresa, Jeffree, Rosalind L., Reid, Lynne E., Da Silva, Leonard, Matsika, Admire, Niland, Colleen M., Cummings, Margaret C., Bruxner, Timothy J. C., Christ, Angelika N., Harliwong, Ivon, Idrisoglu, Senel, Manning, Suzanne, Nourse, Craig, Nourbakhsh, Ehsan, Wani, Shivangi, Anderson, Matthew J., Fink, J. Lynn, Holmes, Oliver, Kazakoff, Stephen, Leonard, Conrad, Newell, Felicity, Taylor, Darrin, Wood, Scott, Xu, Qinying, Kassahn, Karin S., Narayanan, Vairavan, Taib, Nur Aishah, Teo, Soo-Hwang, Chow, Yock Ping, kConFab, Jat, Parmjit S., Brandner, Sebastian, Flanagan, Adrienne M., Khanna, KumKum, Chenevix-Trench, Georgia, Grimmond, Sean M., Simpson, Peter T., Waddell, Nicola and Lakhani, Sunil R. (2015) Integrated genomic and transcriptomic analysis of human brain metastases identifies recurrently altered pathways of potential clinical significance. Journal of Pathology, 237 3: 363-378. doi:10.1002/path.4583

  • Bessette, Darrell C., Tilch, Erik, Seidens, Tatjana, Quinn, Michael C. J., Wiegmans, Adrian P., Shi, Wei, Cocciardi, Sibylle, McCart-Reed, Amy, Saunus, Jodi M., Simpson, Peter T., Grimmond, Sean M., Lakhani, Sunil R., Khanna, Kum Kum, Waddell, Nic, Al-Ejeh, Fares and Chevenvix-Trench, Georgia (2015) Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib. PLoS One, 10 5: e0125232-e0125232. doi:10.1371/journal.pone.0125232

  • Momeny, Majid, Saunus, Jodi M., Marturana, Flavia, McCart Reed, Amy E., Black, Debra, Sala, Gianluca, Iacobelli, Stefano, Holland, Jane D., Yu, Dihua, Da Silva, Leonard, Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2015) Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget, 6 6: 3932-3946. doi:10.18632/oncotarget.2846

  • Junankar, Simon, Baker, Laura A., Roden, Daniel L., Nair, Radhika, Elsworth, Ben, Gallego-Ortega, David, Lacaze, Paul, Cazet, Aurelie, Nikolic, Iva, Teo, Wee Siang, Yang, Jessica, McFarland, Andrea, Harvey, Kate, Naylor, Matthew J., Lakhani, Sunil R., Simpson, Peter T., Raghavendra, Ashwini, Saunus, Jodi, Madore, Jason, Kaplan, Warren, Ormandy, Christopher, Millar, Ewan K. A., O'Toole, Sandra, Yun, Kyuson and Swarbrick, Alexander (2015) ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype. Nature Communications, 6 6548.1-6548.12. doi:10.1038/ncomms7548

  • Al-Ejeh, F., Simpson, P. T., Sanus, J. M., Klein, K., Kalimutho, M., Shi, W., Miranda, M., Kutasovic, J., Raghavendra, A., Madore, J., Reid, L., Krause, L., Chenevix-Trench, G., Lakhani, S. R. and Khanna, K. K. (2014) Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer. Oncogenesis, 3 4: 1-12. doi:10.1038/oncsis.2014.14

  • Al-Ejeh, Fares, Miranda, Mariska, Shi,Wei, Simpson, Peter T., Song, Sarah, Vargas, Ana Cristina, Saunus, Jodi M., Smart, Chanel E., Mariasegaram, Mythily, Wiegmans, Adrian P., Chenevix-Trench, Georgia, Lakhani, Sunil R. and Khanna, Kum Kum (2014) Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer. Oncotarget, 5 10: 3145-3158. doi:10.18632/oncotarget.1865

  • Smart, Chanel E., Morrison, Brian J., Saunus, Jodi M., Vargas, Ana Cristina, Keith, Patricia, Reid, Lynne, Wockner, Leesa, Amiri, Marjan Askarian, Sarkar, Debina, Simpson, Peter T., Clarke, Catherine, Schmidt, Chris W., Reynolds, Brent A., Lakhani, Sunil R. and Lopez, J. Alejandro (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PloS One, 8 6: . doi:10.1371/journal.pone.0064388

  • Alizart, Michelle, Saunus, Jodi, Cummings, Margaret and Lakhani, Sunil R. (2012) Molecular classification of breast carcinoma. Diagnostic Histopathology, 18 3: 97-103. doi:10.1016/j.mpdhp.2011.12.003

  • Matias, Marie A.T., Saunus, Jodi M., Ivanovski, Saso, Walsh, Laurence J. and Farah, Camile S. (2011) Accelerated wound healing phenotype in Interleukin 12/23 deficient mice. Journal of Inflammation-London, 8 1: 39-1-39-11. doi:10.1186/1476-9255-8-39

  • Saunus, Jodi M., Momeny, Majid, Simpson, Peter T., Da Silva, Leonard and Lakhani, Sunil R. (2011) Molecular aspects of breast cancer metastasis to the brain. Genetics Research International, 2011 219189-1-219189-9. doi:10.4061/2011/219189

  • Saunus, J.M., Wagner, S.A., Matias, M.A., Hu, Y, Zaini, Z.M. and Farah, C.S. (2010) Early activation of the IL-23-17 axis in a murine model of oropharyngeal candidiasis. Molecular Oral Microbiology, 25 5: 343-356. doi:10.1111/j.2041-1014.2010.00570.x

  • Pettigrew, C. A., French, J. D., Saunus, J. M., Edwards, S. L., Sauer, A. V., Smart, C. E., Lundstrom, H. T., Wiesner, C., Spurdle, A. B., Rothnagel, J. A. and Brown, M. A. (2010) Identification and functional analysis of novel BRCA1 transcripts, including mouse Brca1-Iris and human pseudo-BRCA1. Breast Cancer Research and Treatment, 119 1: 239-247. doi:10.1007/s10549-008-0256-2

  • Farah, C. S., Saunus, J. M., Hu, Y., Kazoullis, A. and Ashman, R. B. (2009) Gene targeting demonstrates that inducible nitric oxide synthase is not essential for resistance to oral candidiasis in mice, or for killing of Candida albicans by macrophages in vitro. Oral Microbiology and Immunology, 24 1: 83-88. doi:10.1111/j.1399-302X.2008.00462.x

  • Saunus, J., French, J.D., Edwards, S.L., Beveridge, D.J., Hatchell, E.C., Wagner, S.A., Stein, S.R., Davidson, A., Simpson, K.J., Francis, G.D., Leedman, P.J. and Brown, M.A. (2008) Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR. Cancer Research, 68 22: 9469-9478. doi:10.1158/0008-5472.CAN-08-1159

  • Saunus, J. M., Kazoullis, A. and Farah, C. S. (2008) Cellular and molecular mechanisms of resistance to oral Candida albicans infections. Frontiers In Bioscience, 13 1: 5345-5358. doi:10.2741/3085

  • Saunus, Jodi M., Edwards, Stacey L., French, Juliet D., Smart, Chanel E. and Brown, Melissa A. (2007) Regulation of BRCA1 messenger RNA stability in human epithelial cell lines and during cell cycle progression. FEBS Letters, 581 18: 3435-3442. doi:10.1016/j.febslet.2007.06.046

Conference Publication

  • Kalita de Croft, Priyakshi , Straube, Jasmin , Al-Ejeh, Fares , M Saunus,Jodi and R Lakhani, Sunil (2018). Proteomic analysis of the mouse brain stromal microenvironment: a milieu intérieur of metabolic reprogramming. In: 30th Lorne Cancer Conference 2018, Lorne, Victoria, Australia, (). 8th-11th February, 2018.

  • Saunus, Jodi M., Kalita-de Croft, Priyakshi, Lee, F. T., Al-Ejeh, Fares, Lim, Malcolm, Ensbey, Kathleen, Niland, Colleen, Jeffree, Rosalind L., Thomas, Paul, Day, Bryan W., Rose, Stephen, Scott, Andrew M. and Lakhani, Sunil R. (2016). Investigating the Her2-3 dimer as a theranostic target in brain metastases. In: COSA's 43 and ANZBCTG's 38 Annual Scientific Meetings. Partners for Progress in Breast Cancer Research and Care, Gold Coast, QLD Australia, (114-114). 15-17 November 2016. doi:10.1111/ajco.12646

  • Saunus, Jodi M., Momeny, Majid, Da Silva, Leonard, Reid, Lynne, Holland, Jane D., Birchmeier, Walter, Jat, Parmjit, Brandner, Sebastian, Al-Ejeh, Fares, Khanna, Kum Kum, Chenevix-Trench, Georgia, Simpson, Peter T. and Lakhani, Sunil R. (2015). Exploring the HER3 tyrosine kinase as a therapeutic target for treatment of brain metastases. In: Abstracts - 15th International Biennial Congress of the Metastasis Research Society. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, (236-236). 28 June - 01 July 2014. doi:10.1007/s10585-015-9708-3

  • Saunus, J. M., Quinn, M. C. J., Patch, A. M., Pearson, J. V., Bailey, P. J., Cloonan, N., Nones, K., Miller, D., Mariasegaram, M., Lau, Q., Jeffree, L., Khanna, K. K., Chenevix-Trench, G., Grimmond, S. M., Simpson, P. T., Waddell, N. and Lakhani, S. R. (2015). Genomic and transcriptomic landscapes of human brain metastases. In: 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, (236-236). June 28th–July 1st, 2014. doi:10.1007/s10585-015-9708-3

  • Saunus, Jodi (2012). Defining mechanisms underlying breast cancer metastasis to brain. In: New Zealand Society for Oncology Conference 2012, Wellington New Zealand, (). 3-4 May 2012.

  • Saunus, Jodi M., Da Silva, Leonard, Momeny, Majid, Morrison, Brian, Lane, Annette, Smart, Chanel, Al-Ejeh, Fares, Khanna, Kum Kum, Chenevix-Trench, Georgia, Simpson, Peter T. and Lakhani, Sunil R. (2012). Role of HER3 in brain metastases from primary breast cancer. In: 24th Lorne Cancer Conference, Lorne, VIC, Australia, (). 9-12 February 2012.

  • Saunus, Jodi M., Momeny, Majid, Da Silva, Leonard, Vargas, Ana Cristina, Al-Ejeh, Fares, Morrison, Brian, Khanna, Kum Kum, Grimmond, Sean, Chenevix-Trench, Georgia, Jeffree, Rosalind L., Waddell, Nicola, Simpson, Peter T. and Lakhani, Sunil R. (2012). Uncovering molecular mechanisms involved in metastasis to the brain. In: 14th International Biennial Congress of the Metastasis Research Society, Brisbane, QLD, Australia, (). 2-5 September 2012.

  • Smart, Chanel E., Saunus, Jodi M., Keith, Patricia, Vargas, Ana Cristina, Malik, Neelam, Clarke, Catherine, Simpson, Peter T. and Lakhani, Sunil R. (2010). Shifting phenotypes in primary human mammary epithelial culture. In: Sixth International Conference on Hormonal Oncogenesis, Tokyo, Japan, (). 12-16 September 2010.

  • Saunus, Jodi M., Young, Tiffany J. and Farah. Camile S. (2009). Isolation of epithelial stem cells from normal and dysplastic oral epithelium. In: Gordon Research Conference: Molecular Mechanisms Controlling Normal and Cancer Stem Cells, Les Diablerets, Switzerland, (). 13-18 September 2009.

  • French, J. D., Edwards, S. L., Saunus, J. M., Tan-Wong, S. M., Brewster, B., Hardie, K. M., Leedman, P. J., Proudfoot, N. J. and Brown, M. A. (2008). Identification of functional regulatory elements in the non-coding regions of the BRCA1 gene. In: kConFab Familial Breast Cancer conference 2008, Couran Cove, Queensland, (). 2008.

  • French, J. D., Wong, S. M., Saunus, J. M., Smart, C. E., Proudfoot, N. J. and Brown, M. A. (2007). Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene. In: Australian Breast Cancer Conference 2007, Melbourne, Australia, (). 19-20 November 2007.

  • Brewster, B., Brown, M. A., Edwards, S. L., French, J. D., Leedman, P., Proudfoot, N. J., Saunus, J. M., Southey, M., Tavtigian, S and Wong, S. M. (2007). Identification of novel mutation targets in the breast cancer susceptibility gene BRCA1 and genes that encode regulators of BRCA1. In: kConFab Familial Breast Cancer Conference. kConFab Familial Breast Cancer Conference, Couran Cove, Queensland, (). 21-24 August 2007.

  • Saunus, Jodi M., French, Juliet D., Edwards, Stacey L., Beveridge, Dianne J., Hatchell, Esme C., Wagner, Sarah A., Gason, Alexandra A., Simpson, Kaylene J., Leedman, Peter J. and Brown, Melissa A. (2006). Identification of RNA-binding proteins that regulate BRCA1 expression. In: Familial Cancer 2006: Research and Practice. A combined meeting of kConFab, Australian Ovarian Cancer Study (AOCS) and the Family Cancer Clinics of Australia and New Zealand, Couran Cove, South Stradbroke Island, Queensland, Australia, (). 16-19 August 2006.

  • Saunus, Jodi M., Wardrop, Stacey L., French, Juliet D., Beveridge, Dianne J., Hatchell, Esme C., Dinnis, Diane M., Gason, Alexandra A., Simpson, Kaylene J., Leedman, Peter J. and Brown, Melissa A. (2006). Post-transcriptional regulation of the breast cancer susceptibility gene BRCA1 by Hu Antigen-R. In: ComBio 2006, Brisbane, Queensland, Australia, (). 24-28 September, 2006.

  • Saunus, J. M., Wardrop, S. L., French, J. D., Beveridge, D. J., Hatchell, E. C., Gason, A. A., Simpson, K.J., Leedman, P. J. and Brown, M. A. (2005). Hur post-transcriptionally regulates BRCA1: involvement of elements in the BRCA1 3' untranslated region. In: Proceedings of the Molecular Approaches to Controlling Cancer Conference. Molecular Approaches to Controlling Cancer, New York, (). 3-5 June, 2005.

  • French, J. D., Saunus, J. M., Wardrop, S. L. and Brown, M. A. (2005). Regulation of BRCA1 by Heregulin. In: Proceedings of the Familial Cancer 2005: Research and Practice. Familial Cancer 2005: Research and Practice, Couran Cove, (). 30 Aug - 3 Sept, 2005.

  • Wardrop, S. L., Saunus, J. M., French, J. D., Leedman, P. J. and Brown, M. A. (2005). Transcriptional and post-transcriptional regulation of the breast cancer susceptibility gene 1 (BRCA1). In: Proceedings of the National Cancer Research Institute Conference. National Cancer Research Institute Conference, Birmingham, UK, (). 2-5 Oct, 2005.

  • Saunus, J. M., Wardrop, S. L. and Brown, M. A. (2002). Identification of cis and trans regulators in the BRCA1 3'untranslated region. In: Proceedings of the Australian Society for Biochemistry and Molecular Biology. ComBio 2002, Sydney, Australia, (). 29 September - 3 October, 2002.

Other Outputs

PhD and MPhil Supervision

Note for students: Dr Jodi Saunus is not currently available to take on new students.

Current Supervision