Towards selective targeting of HDACs for anti-inflammatory applications (2009–2011)

Abstract:
HDAC inhibitors are anti-cancer drugs that kill rapidly growing cells (like cancer cells). These drugs also have anti-inflammatory properties and so may be beneficial in chronic inflammatory diseases such as as Rheumatoid Arthritis. However, it is unknown how they reduce inflammation. In this project we aim to understand how HDAC inhibitors act as anti-inflammatory agents and to design new HDAC inhibitors with reduced side effects for the treatment of inflammatory diseases.
Grant type:
NHMRC Project Grant
Researchers:
  • Professorial Research Fellow
    Institute for Molecular Bioscience
    Affiliated Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
  • NHMRC Snr Principal Research Fellow
    Institute for Molecular Bioscience
    Affiliated Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
  • ARC Future Fellow
    Mater Research Institute-UQ
    Faculty of Medicine
  • Adjunct Research Fellow
    Institute for Molecular Bioscience
  • Senior Biologist
    Institute for Molecular Bioscience
Funded by:
National Health and Medical Research Council