Lipid and Carbohydrate Based Systems to Target and Deliver Peptide Drug Candidates to Specific Cells (2010–2013)

Abstract:
Many peptide-based compounds have been identified as potential new drugs and vaccines but few have progressed into the clinic, due to lack of oral absorption and rapid enzymatic breakdown. Our project will address these issues employing a highly novel strategy involving naturally occurring sugars and lipids. Our delivery system which contains a carbohydrate-based targeting unit will be conjugated to the peptide/lipopeptide of interest (drug or vaccine candidate) using chemical and enzymatic methods. Most importantly this proof of principle approach has the potential to not only improve the drug bioavailability, but to also enhance the access to the target sites.
Grant type:
ARC Discovery Projects
Researchers:
  • Chair in Biological Chemistry
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Professor (Level E)
    School of Pharmacy
    Faculty of Health and Behavioural Sciences
    Affil Professorial Research Fellow
    Institute for Molecular Bioscience
  • Written Examination Lead
    Office of Medical Education
    Faculty of Medicine
Funded by:
Australian Research Council